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Increased Angio-Derived Index of Microcirculatory Resistance Within a Timeframe of 30–60 days After COVID-19 Infection Microcirculation (IF 2.4) Pub Date : 2024-03-18 Lei Dong, Ritai Na, Lang Peng, Xinye Xu
Chest pain is a relatively long-term symptom that commonly occurs in patients who have contracted COVID-19. The reasons for these symptoms remain unclear, with coronary microvascular dysfunction (CMD) emerging as a potential factor. This study aimed to assess the presence of CMD in these patients by measuring the angio-derived index of microcirculatory resistance (AMR).
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Modeling cerebrovascular responses to assess the impact of the collateral circulation following middle cerebral artery occlusion Microcirculation (IF 2.4) Pub Date : 2024-02-14 Erin Zhao, Jared Barber, Shomita S. Mathew-Steiner, Savita Khanna, Chandan K. Sen, Julia Arciero
An improved understanding of the role of the leptomeningeal collateral circulation in blood flow compensation following middle cerebral artery (MCA) occlusion can contribute to more effective treatment development for ischemic stroke. The present study introduces a model of the cerebral circulation to predict cerebral blood flow and tissue oxygenation following MCA occlusion.
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Correction Microcirculation (IF 2.4) Pub Date : 2024-02-11
Correction for article ‘Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model’. Steinskog ESS, Finne K, Enger M,et al. Isolation of lymph shows dysregulation of STAT3 andCREB pathways in the spleen and liver during leukemiadevelopment in a rat model. Microcirculation. 2023;30:e12800. doi:10.1111/micc.12800 The authors would
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Sex-specific microvascular and hemodynamic responses to passive limb heating in young adults Microcirculation (IF 2.4) Pub Date : 2024-01-28 Miranda K. Traylor, Genevieve B. Batman, Kylie N. Sears, Kyndall V. Ransom, Shane M. Hammer, Joshua L. Keller
We examined sex-specific microvascular reactivity and hemodynamic responses under conditions of augmented resting blood flow induced by passive heating compared to normal blood flow.
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Impact of stalling events on microcirculatory hemodynamics in the aged brain Microcirculation (IF 2.4) Pub Date : 2024-01-24 Mohammad Jamshidi, Thomas Ventimiglia, Patrice Sudres, Cong Zhang, Frédéric Lesage, William Rooney, Daniel Schwartz, Andreas A. Linninger
The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.
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Retinal vascular dynamics: A window for observing an irregular heartbeat. A case report Microcirculation (IF 2.4) Pub Date : 2024-01-19 Rebekka Heitmar, Paulus Kirchhoff, Andrew Blann, Konstantin Kotliar
We aimed to characterize several aspects of retinal vascular dynamics in a patient with arrythmia in order to elicit additional diagnostic information on microvascular dysfunction.
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Men with nonobstructive coronary disease have higher burden of ischemic heart disease detected by cardiopulmonary exercise test Microcirculation (IF 2.4) Pub Date : 2024-01-17 Siyuan Li, Yifang Yuan, Lanting Zhao, Tingting Lv, Fei She, Fang Liu, Yajun Xue, Boda Zhou, Ying Xie, Yu Geng, Ping Zhang
Nonobstructive coronary artery disease (NOCAD), characterized by the presence of myocardial ischemic symptoms and signs without obstructive coronaries, is a common clinical condition, but it is less well understood. Few studies have analyzed the gender differences in inducible myocardial ischemia assessed by cardiopulmonary exercise test (CPET) in NOCAD.
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Cover Image Microcirculation (IF 2.4) Pub Date : 2024-01-16 Summer N. Horchler, Patrick C. Hancock, Mingjie Sun, Alexander T. Liu, Sameer Massand, Jessica C. El-Mallah, Dana Goldenberg, Olivia Waldron, Mary E. Landmesser, Shailaja Agrawal, Srinivas V. Koduru, Dino J. Ravnic
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Coronary microvascular dysfunction as assessed by multimodal diagnostic imaging in patients with hypertrophic cardiomyopathy is related to the severity of cardiac dysfunction Microcirculation (IF 2.4) Pub Date : 2024-01-04 Tien Vuong Tran, Loic Djaileb, Laurent Riou, Lea Ruez Lantuejoul, Joris Giai, Gilles Barone-Rochette
Coronary microvascular dysfunction (CMD) plays a major role in hypertrophic cardiomyopathy (HCM) physiopathology but its assessment in clinical practice remains a challenge. Nowadays, innovations in invasive and noninvasive coronary evaluation using multimodal imaging provide options for the diagnosis of CMD. The objective of the present study was to investigate if new multimodal imaging diagnosis
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Nitric oxide-mediated vasodilation in human bone Microcirculation (IF 2.4) Pub Date : 2023-12-22 Adina E. Draghici, Matthew R. Ely, Jason W. Hamner, J. Andrew Taylor
Regulation of blood flow to bone is critical but poorly understood, particularly in humans. This study aims to determine whether nitric oxide (NO), a major regulator of vascular tone to other tissues, contributes also to the regulation of blood flow to bone.
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Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype Microcirculation (IF 2.4) Pub Date : 2023-12-11 Rafal Gulej, Boglarka Csik, Janet Faakye, Stefano Tarantini, Santny Shanmugarama, Siva Sai Chandragiri, Peter Mukli, Shannon Conley, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy, Ádám Nyúl-Tóth
Age-related blood–brain barrier (BBB) disruption, cerebromicrovascular senescence, and microvascular rarefaction substantially contribute to the pathogenesis of vascular cognitive impairment (VCI) and Alzheimer's disease (AD). Previous studies established a causal link between age-related decline in circulating levels of insulin-like growth factor-1 (IGF-1), cerebromicrovascular dysfunction, and cognitive
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Flow-dependent regulation of rat mesenteric lymphatic vessel contractile response requires activation of endothelial TRPV4 channels Microcirculation (IF 2.4) Pub Date : 2023-12-04 Jacques DuToit, Peter Brothers, Matthew Stephens, Keith Keane, Flavia Neto de Jesus, Simon Roizes, Pierre-Yves von der Weid
The objective of our study is to evaluate the involvement of the transient receptor potential vanilloid 4 (TRPV4) in the alteration of lymphatic pumping in response to flow and determine the signaling pathways involved.
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Emerging role of YAP/TAZ in vascular mechanotransduction and disease Microcirculation (IF 2.4) Pub Date : 2023-11-27 Olivia Ritsvall, Sebastian Albinsson
Cells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli, referring
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Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries Microcirculation (IF 2.4) Pub Date : 2023-11-20 Nadim Naser, Chenchel K. Lonj, Matthew Rikard-Bell, Shaun L. Sandow, Timothy V. Murphy
This study investigated the actions of advanced glycated end-products (AGE), their receptors (RAGE), and NAD(P)H oxidase (Nox) subtypes 1, 2, and 4 on mechanisms of endothelium-dependent dilation of the rat cremaster muscle artery (CMA).
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Vascular persistence following precision micropuncture Microcirculation (IF 2.4) Pub Date : 2023-11-10 Summer N. Horchler, Patrick C. Hancock, Mingjie Sun, Alexander T. Liu, Sameer Massand, Jessica C. El-Mallah, Dana Goldenberg, Olivia Waldron, Mary E. Landmesser, Shailaja Agrawal, Srinivas V. Koduru, Dino J. Ravnic
The success of engineered tissues continues to be limited by time to vascularization and perfusion. Recently, we described a simple microsurgical approach, termed micropuncture (MP), which could be used to rapidly vascularize an adjacently placed scaffold from the recipient macrovasculature. Here we studied the long-term persistence of the MP-induced microvasculature.
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Vascular polycystin proteins in health and disease Microcirculation (IF 2.4) Pub Date : 2023-10-12 Ulrich C. Mbiakop, Jonathan H. Jaggar
PKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act as a mechanosensor and receptor. PKD2 is a member of the transient receptor potential (TRP) channel superfamily which is also termed TRPP1. Mutations
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The effect of sepsis and reactive oxygen species on skeletal muscle interstitial oxygen pressure during contractions Microcirculation (IF 2.4) Pub Date : 2023-10-06 Naoki Hitosugi, Kazuki Hotta, Yoshikazu Taketa, Ren Takamizawa, Yutaka Fujii, Ryo Ikegami, Hajime Tamiya, Tatsuro Inoue, Atsuhiro Tsubaki
This study aims to examine the effect of sepsis on the dynamics of skeletal muscle partial oxygen pressure during muscle contractions as well as the effect of reactive oxygen species (ROS) scavenger (ascorbic acid, Asc).
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The role of glycosaminoglycans in blood pressure regulation Microcirculation (IF 2.4) Pub Date : 2023-10-04 Baris Afsar, Rengin Elsurer Afsar
Essential hypertension (HT) is the global health problem and is a major risk factor for the development of cardiovascular and kidney disease. High salt intake has been associated with HT and impaired kidney sodium excretion is considered to be a major mechanism for the development of HT. Although kidney has a very important role in regulation of BP, this traditional view of BP regulation was challenged
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Arf6 is required for endocytosis and filamentous actin assembly during angiogenesis in vitro Microcirculation (IF 2.4) Pub Date : 2023-09-26 Caitlin R. Francis, Makenzie L. Bell, Marina M. Skripnichuk, Erich J. Kushner
Endocytosis is a process vital to angiogenesis and vascular homeostasis. In pathologies where supraphysiological growth factor signaling underlies disease etiology, such as in diabetic retinopathy and solid tumors, strategies to limit chronic growth factor signaling by way of blunting endocytic processes have been shown to have tremendous clinical value. ADP ribosylation factor 6 (Arf6) is a small
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Estimation of shear stress heterogeneity along capillary segments in angiogenic rat mesenteric microvascular networks Microcirculation (IF 2.4) Pub Date : 2023-09-09 Nien-Wen Hu, Banks M. Lomel, Elijah W. Rice, Mir Md Nasim Hossain, Malisa Sarntinoranont, Timothy W. Secomb, Walter L. Murfee, Peter Balogh
Fluid shear stress is thought to be a regulator of endothelial cell behavior during angiogenesis. The link, however, requires an understanding of stress values at the capillary level in angiogenic microvascular networks. Critical questions remain. What are the stresses? Do capillaries experience similar stress magnitudes? Can variations explain vessel-specific behavior? The objective of this study
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The association between hypoalbuminemia and microcirculation, endothelium, and glycocalyx disorders in children with sepsis Microcirculation (IF 2.4) Pub Date : 2023-08-28 Jaime Fernández-Sarmiento, Ricardo Hernández-Sarmiento, María Paula Salazar, Sofia Barrera, Valeria Castilla, Catalina Duque
The objective of this study was to evaluate the association between serum albumin levels and microcirculation changes, glycocalyx degradation, and the clinical outcomes of interest.
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Progress in molecular mechanisms of coronary microvascular dysfunction Microcirculation (IF 2.4) Pub Date : 2023-08-22 Hao Li, Yuping Gao, Yuanyuan Lin
Coronary microvascular dysfunction is a high-risk factor for many cardiovascular events. However, because of multiple risk factors and limited understanding about its underlying pathophysiological mechanisms, it was easily misdiagnosed. Therefore, its clinical diagnosis and treatment were greatly restricted. Coronary microcirculation refers to microvessels that play an important role in the physiological
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Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart Microcirculation (IF 2.4) Pub Date : 2023-08-22 Evan H. Phillips, Vytautas P. Bindokas, Dahee Jung, Jay Teamer, Jan K. Kitajewski, R. John Solaro, Beata M. Wolska, Steve Seung-Young Lee
Three-dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association with other cell types. We aimed to develop a methodology for 3D multiplexed lightsheet microscopy and highly sensitive and quantitative image analysis to identify pathological remodeling in the 3D morphology of LyVs in young adult mouse hearts
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Cover Image Microcirculation (IF 2.4) Pub Date : 2023-08-10 Julie Leonard-Duke, Anthony C. Bruce, Shayn M. Peirce, Lakeshia J. Taite
The cover image is based on the Original Article Variations in mechanical stiffness alter microvascular sprouting and stability in a PEG hydrogel model of idiopathic pulmonary fibrosis by Julie Leonard-Duke et al., https://doi.org/10.1111/micc.12817.
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Corrigendum Microcirculation (IF 2.4) Pub Date : 2023-08-10
Corrigendum to ‘Endothelial cell membrane cholesterol content regulates the contribution of TRPV4 channels in ACh-induced vasodilation in rat gracilis arteries' Morin EE, Salbato S, Walker BR, Naik JS. Endothelial cell membrane cholesterol content regulates the contribution of TRPV4 channels in ACh-induced vasodilation in rat gracilis arteries. Microcirculation. 2022;29:e12774. In the above article
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Beneficial effects of empagliflozin and liraglutide on the cerebral microcirculation of diabetic rats Microcirculation (IF 2.4) Pub Date : 2023-08-07 Joana Costa d'Avila, Aluana Santana Carlos, Raimundo Lima Vieira, Carla Vergueiro, Aline Teixeira Lima, Isaias dos Santos Silva, Vivian Carvalho de Figueiredo, Paulo Henrique Petrone Chateaubriand, Adalgiza Mafra Moreno, Hugo Caire de Castro Faria Neto, Vanessa Estato, Rodrigo Azeredo Siqueira
This study aimed to evaluate the effects of the antidiabetics liraglutide, a GLP-1 analog, and empagliflozin, an SGLT-2 inhibitor, on the brain microcirculation of diabetic rats.
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Removal of the endothelial surface layer via hyaluronidase does not modulate monocyte and neutrophil interactions with the glomerular endothelium Microcirculation (IF 2.4) Pub Date : 2023-07-26 ZheHao Tan, Pam Hall, Adam Costin, Simon A. Crawford, Georg Ramm, Connie H. Y. Wong, A. Richard Kitching, Michael J. Hickey
The endothelial surface layer (ESL), a layer of macromolecules on the surface of endothelial cells, can both impede and facilitate leukocyte recruitment. However, its role in monocyte and neutrophil recruitment in glomerular capillaries is unknown.
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Microvascular dysfunction in patients with heart failure with preserved ejection fraction: A meta-analysis Microcirculation (IF 2.4) Pub Date : 2023-07-25 Mai Azuma, Shingo Kato, Kazuki Fukui, Nobuyuki Horita, Daisuke Utsunomiya
Although microvascular dysfunction (MVD) is considered an essential pathophysiology in patients with heart failure with preserved ejection fraction (HFpEF), the frequency and prognostic impact of MVD are not fully understood. This meta-analysis evaluated the frequency of MVD in patients with HFpEF and its utility in risk stratification.
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Extended-volume image-derived models of coronary microcirculation Microcirculation (IF 2.4) Pub Date : 2023-07-01 Vibujithan Vigneshwaran, Christine Lauren Sy, Bruce H. Smaill, Gregory B. Sands, Nicolas P. Smith
Recent advances in tissue clearing and high-throughput imaging have enabled the acquisition of extended-volume microvasculature images at a submicron resolution. The objective of this study was to extract information from this type of images by integrating a sequence of 3D image processing steps on Terabyte scale datasets.
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The sublingual microcirculation and frailty index in chronic kidney disease patients Microcirculation (IF 2.4) Pub Date : 2023-06-07 Ryan A. P. Homes, Fiona Giddens, Ross S. Francis, Ruth E. Hubbard, Emily H. Gordon, Mark J. Midwinter
To examine the relationship between sublingual microcirculatory measures and frailty index in those attending a kidney transplant assessment clinic.
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Variations in mechanical stiffness alter microvascular sprouting and stability in a PEG hydrogel model of idiopathic pulmonary fibrosis Microcirculation (IF 2.4) Pub Date : 2023-05-29 Julie Leonard-Duke, Anthony C. Bruce, Shayn M. Peirce, Lakeshia J. Taite
Microvascular remodeling is governed by biomechanical and biochemical cues which are dysregulated in idiopathic pulmonary fibrosis. Understanding how these cues impact endothelial cell-pericyte interactions necessitates a model system in which both variables can be independently and reproducibly modulated. In this study we develop a tunable hydrogel-based angiogenesis assay to study how varying angiogenic
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Circadian and sex differences in post-ischemic vasodilation and reactive hyperemia in young individuals and elderly with and without type 2 diabetes Microcirculation (IF 2.4) Pub Date : 2023-05-29 Alessandro Gentilin, Paolo Moghetti, Antonio Cevese, Anna Vittoria Mattioli, Federico Schena, Cantor Tarperi
Cardiovascular events show morning preference and sex differences, and are related to aging and type 2 diabetes. We assessed circadian variations and sex differences in vascular conductance (VC) and blood flow (BF) regulations following a brief bout of forearm ischemia.
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5-HT7 receptors mediate dilation of rat cremaster muscle arterioles in vivo Microcirculation (IF 2.4) Pub Date : 2023-05-19 William F. Jackson, Armond Daci, Janice M. Thompson, Gregory D. Fink, Stephanie W. Watts
Serotonin (5-HT) infusion in vivo causes hypotension and a fall in total peripheral resistance. However, the vascular segment and the receptors that mediate this response remain in question. We hypothesized that 5-HT7 receptors mediate arteriolar dilation to 5-HT in skeletal muscle microcirculation.
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Lymphatic Pathophysiology Microcirculation (IF 2.4) Pub Date : 2023-04-20 Sanjukta Chakraborty, Brandon J. Dixon, Joseph M. Rutkowski, Jorge A. Castorena-Gonzalez, Jerome W. Breslin
CONFLICT OF INTEREST STATEMENT None declared.
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Impaired peripheral microvascular reactivity in patients with nonobstructive coronary artery disease Microcirculation (IF 2.4) Pub Date : 2023-04-20 Zulkefli Sanip, Nurnajwa Pahimi, Nur Adilah Bokti, Zurkurnai Yusof, Mohd Sapawi Mohamed, W. Yus Haniff W. Isa, Aida Hanum Rasool
This study aimed to determine whether peripheral microvascular reactivity is impaired in patients with nonobstructive coronary artery disease (NOCAD).
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Fixing skeletal muscle PO2 eliminates hyperinsulinemic microvascular blood flow response Microcirculation (IF 2.4) Pub Date : 2023-03-14 Brenda N. Wells, Gaylene M. Russell McEvoy, Hamza Shogan, Meghan E. Kiley, Graham M. Fraser
To determine if insulin-mediated hyperemia is partially dependent on local muscle oxygen concentration.
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Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients Microcirculation (IF 2.4) Pub Date : 2023-03-14 Chen Chen, Bai Lin Zhu, Wei Da Zheng, Zhen Yi Guo, Xin Jin, Zai Hao Zhao, Mei Hua Lin, Lan Cui, Yin Hua Zhang
Impaired microcirculation in acute coronary syndrome (ACS) patients manifests inadequate recovery and adverse clinical outcome. Here, we analyzed correlations between peripheral microcirculation and heart function in ACS patients.
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Association between mean arterial pressure and sublingual microcirculation during major non-cardiac surgery: Post hoc analysis of a prospective cohort Microcirculation (IF 2.4) Pub Date : 2023-03-11 Eleni Laou, Nikolaos Papagiannakis, Anastasia Michou, Nicoleta Ntalarizou, Dimitrios Ragias, Zacharoula Angelopoulou, Daniel I. Sessler, Athanasios Chalkias
To test the hypothesis that there is an association between mean arterial pressure (MAP) and sublingual perfusion during major surgery, and perhaps an identifiable harm threshold.
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Modeling lymphangiogenesis: Pairing in vitro and in vivo metrics Microcirculation (IF 2.4) Pub Date : 2023-02-09 Aileen C. Suarez, Jennifer H. Hammel, Jennifer M. Munson
Lymphangiogenesis is the mechanism by which the lymphatic system develops and expands new vessels facilitating fluid drainage and immune cell trafficking. Models to study lymphangiogenesis are necessary for a better understanding of the underlying mechanisms and to identify or test new therapeutic agents that target lymphangiogenesis. Across the lymphatic literature, multiple models have been developed
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Sublingual microcirculation and internal environment changes as early indications of sepsis: A prospective observational study Microcirculation (IF 2.4) Pub Date : 2023-01-30 Yi Lu, Jun Yang, Peng Li, Fei Teng, Shubin Guo
This study aims to investigate the changes in microcirculation and internal environment before sepsis in patients with infectious diseases.
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Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model Microcirculation (IF 2.4) Pub Date : 2023-01-26 Eli Sihn Samdal Steinskog, Kenneth Finne, Marianne Enger, Lars Helgeland, Per Ole Iversen, Emmet McCormack, Helge Wiig, Olav Tenstad
Acute myeloid leukemia (AML) is a heterogeneous malignant condition characterized by massive infiltration of poorly differentiated white blood cells in the blood stream, bone marrow, and extramedullary sites. During leukemic development, hepatosplenomegaly is expected to occur because large blood volumes are continuously filtered through these organs. We asked whether infiltration of leukemic blasts
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Statistical and topological summaries aid disease detection for segmented retinal vascular images Microcirculation (IF 2.4) Pub Date : 2023-01-12 John T. Nardini, Charles W. J. Pugh, Helen M. Byrne
Disease complications can alter vascular network morphology and disrupt tissue functioning. Microvascular diseases of the retina are assessed by visual inspection of retinal images, but this can be challenging when diseases exhibit silent symptoms or patients cannot attend in-person meetings. We examine the performance of machine learning algorithms in detecting microvascular disease when trained on
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Anxiety is associated with coronary microvascular dysfunction: Results from the CAMADA study Microcirculation (IF 2.4) Pub Date : 2023-01-12 Ying Li, Weixian Xu, Lijun Guo
Coronary microvascular dysfunction (CMD) is an important component of ischemic heart disease. Here, we assessed the associations between anxiety/depression and CMD using coronary microvascular function indicators.
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KIR channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's disease Microcirculation (IF 2.4) Pub Date : 2022-12-28 Md A. Hakim, Erik J. Behringer
Endothelial cell (EC) coupling occurs through gap junctions and underlies cerebral blood flow regulation governed by inward-rectifying K+ (KIR) channels. This study addressed effects of KIR channel activity on EC coupling before and during Alzheimer's disease (AD).
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Serine proteases mediate leukocyte recruitment and hepatic microvascular injury in the acute phase following extended hepatectomy Microcirculation (IF 2.4) Pub Date : 2022-12-28 Yunjie Zhang, Patrick Huber, Marc Praetner, Alice Zöllner, Lesca Holdt, Andrej Khandoga, Maximilian Lerchenberger
Post-hepatectomy liver failure (PHLF) is the main limitation of extended liver resection. The molecular mechanism and the role of leukocytes in the development of PHLF remain to be unveiled. We aimed to address the impact of serine proteases (SPs) on the acute phase after liver resection by intravitally analyzing leukocyte recruitment and changes in hemodynamics and microcirculation of the liver.
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Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement Microcirculation (IF 2.4) Pub Date : 2022-12-15 Goksel Guven, Annemieke Dijkstra, Tjallingius Martijn Kuijper, Nicole Trommel, Margriet Elisabeth van Baar, Arzu Topeli, Can Ince, Cornelis Hendrik van der Vlies
Laser-based tissue perfusion monitoring techniques have been increasingly used in animal and human research to assess blood flow. However, these techniques use arbitrary units, and knowledge about their comparability is scarce. This study aimed to model the relationship between laser speckle contrast imaging (LSCI) and laser Doppler perfusion imaging (LDPI), for measuring tissue perfusion over a wide
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Impairment of endothelial progenitor cells in women after kidney transplantation Microcirculation (IF 2.4) Pub Date : 2022-12-09 Nadia Meyer, Katja Richter, Lars Brodowski, Constantin von Kaisenberg, Anette Melk, Bernhard Schmidt, Florian P. Limbourg, Bianca Schröder-Heurich, Frauke von Versen-Höynck
The long-term survival of kidney transplant patients has substantially improved. However, there is a higher risk for cardiovascular events after transplantation, partly due to immunosuppression. A diminished number of endothelial progenitor cells (EPCs), which play an important role in angiogenesis and the repair of endothelial damage, are associated with an increased cardiovascular risk. The aim of
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Engineered models of the lymphatic vascular system: Past, present, and future Microcirculation (IF 2.4) Pub Date : 2022-11-22 Amirali Selahi, Abhishek Jain
The lymphatic vascular system is crucial for optimizing body fluid level, regulating immune function, and transporting lipid. Relative to the experimental models to investigate blood vasculature, there are significantly fewer tools to explore lymphatics. Although in vivo studies have contributed to major discoveries in the field, finding and characterizing lymphatic specific markers has opened the
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Lentiviral overexpression of VEGFC in transplanted MSCs leads to resolution of swelling in a mouse tail lymphedema model Microcirculation (IF 2.4) Pub Date : 2022-11-12 Eleftheria Michalaki, Josephine M. Rudd, Lauren Liebman, Rahul Wadhwani, Levi B. Wood, Nick J. Willett, J. Brandon Dixon
Dysfunction of the lymphatic system following injury, disease, or cancer treatment can lead to lymphedema, a debilitating condition with no cure. Despite the various physical therapy and surgical options available, most treatments are palliative and fail to address the underlying lymphatic vascular insufficiency driving lymphedema progression. Stem cell therapy provides a promising alternative in the
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GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner Microcirculation (IF 2.4) Pub Date : 2022-10-05 Md. Riaj Mahamud, Xin Geng, Lijuan Chen, Zoheb Ahmed, Yenchun Ho, R. Sathish Srinivasan
Lymphatic vessels collect interstitial fluid, immune cells, and digested lipids and return these bodily fluids to blood through two pairs of lymphovenous valves (LVVs). Like other cardiovascular valves LVVs prevent the backflow of blood into the lymphatic vessels. In addition to LVVs, platelets are necessary to prevent the entry of blood into the lymphatic vessels. Platelet thrombi are observed at
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RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy Microcirculation (IF 2.4) Pub Date : 2022-10-05 Annalinda Pisano, Loredana Le Pera, Raffaella Carletti, Bruna Cerbelli, Maria G. Pignataro, Angelina Pernazza, Fabrizio Ferre, Maria Lombardi, Davide Lazzeroni, Iacopo Olivotto, Ornella E. Rimoldi, Chiara Foglieni, Paolo G. Camici, Giulia d'Amati
Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated
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Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping Microcirculation (IF 2.4) Pub Date : 2022-09-28 Michiko Jo, Andrea N. Trujillo, Naotoshi Shibahara, Jerome W. Breslin
Goreisan is a traditional herbal formulation with diuretic properties tested as a clinical therapeutic to alleviate lymphedema in Japan. The present study aimed to determine how Goreisan and its five different components affect lymphatic pump function.
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Irisin inhibits NLRP3 inflammasome activation in HG/HF incubated cardiac microvascular endothelial cells with H/R injury Microcirculation (IF 2.4) Pub Date : 2022-09-24 Chao Xin, Jinglong Zhang, Ningbo Hao, Jianan Wang, Hui Liu, Hanwen Wei, Yong Wang, Chengzhu Wang, Shuo Wang, Chengrong Zheng, Zheng Zhang, Zhitao Jin
NLRP3 inflammasome mediates myocardial ischemia/reperfusion (MI/R) injury and diabetic vascular endothelia dysfunction. However, the role of NLRP3 inflammasome in MI/R injury with diabetes has not been fully described. Irisin plays an important role in anti-inflammation and improves endothelial function in type 2 diabetes. The current study aimed to investigate the effect of irisin on regulating NLRP3
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Visualizing the Microcirculation Microcirculation (IF 2.4) Pub Date : 2022-09-20 Janaka Senarathna, Arvind P. Pathak
CONFLICT OF INTEREST None.
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Analysis and visualization methods for detecting functional activation using laser speckle contrast imaging Microcirculation (IF 2.4) Pub Date : 2022-09-07 Peng Hu, Bochao Niu, Hang Yang, Yang Xia, Donna Chen, Chun Meng, Ke Chen, Bharat Biswal
Previous studies have used regional cerebral blood flow (CBF) hemodynamic response to measure brain activities. In this work, we use a laser speckle contrast imaging (LSCI) apparatus to sample the CBF activation in somatosensory cortex (S1BF) with repetitive whisker stimulation. Traditionally, the CBF activations were processed by depicting the change percentage above baseline; however, it is not clear
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Histone-stimulated platelet adhesion to mouse cremaster venules in vivo is dependent on von Willebrand factor Microcirculation (IF 2.4) Pub Date : 2022-09-03 Justin A. Courson, Fong W. Lam, Kimberly W. Langlois, Rolando E. Rumbaut
Extracellular histones are known mediators of platelet activation, inflammation, and thrombosis. Von Willebrand Factor (vWF) and Toll-like receptor 4 (TLR4) have been implicated in pro-inflammatory and prothrombotic histone responses. The objective of this study was to assess the role of vWF and TLR4 on histone-induced platelet adhesion in vivo.