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Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-03-15 Zijiang Zhu, Yuhan Geng, Long Ma, Keying Yao, Ruitong Chang, Yongming Ma, Jialong Li
Several studies indicate that the cystathionine β-synthase (CBS) gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region may be correlated with coronary artery disease (CAD) susceptibil...
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Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-03-12 Xiaofeng Yang, Jiachun Wei, Lu Sun, Qimei Zhong, Xiaoxuan Zhai, Ya Chen, Shujuan Luo, Chunyan Tang, Lan Wang
Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preec...
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Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-03-12 Jingjing Lu, Zhengsheng Li, Yinan Yang, Fangning Wei
Physical activity has profound benefits on health, especially in patients with cardiovascular and metabolic disease. Exercise training can reduce oxidative stress, improve renal function, and thus ...
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A smartwatch sphygmomanometer-based model for predicting short-term new-onset hypertension in individuals with high-normal blood pressure: a cohort study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-02-12 Yuqi Liu, Zhonghua Lv, Shanshan Zhou, Zihao Fu, Yifei Wang, Li Yi, Xiaolong Li, Ying Wang, Shunying Hu, Zhirui Zhou, Yundai Chen
The objective was to utilize a smartwatch sphygmomanometer to predict new-onset hypertension within a short-term follow-up among individuals with high-normal blood pressure (HNBP).This study consis...
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Exploration and validation of signature genes and immune associations in septic cardiomyopathy Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-01-27 Zhengbo Zhao, Xiaojing Wang, Fangyan Tan, Han Liu, Wan Chen, Jing Wang, Songbai Deng, Jianlin Du
An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections i...
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Optimizing the aldosterone-to-renin ratio cut-off for screening primary aldosteronism based on cardiovascular risk: a collaborative study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-01-25 Chunxue He, Ruolin Li, Jun Yang, Hang Shen, Yue Wang, Xiangjun Chen, Wenjin Luo, Qinglian Zeng, Linqiang Ma, Ying Song, Qingfeng Cheng, Zhihong Wang, Fei-Fei Wu, Qifu Li, Shumin Yang, Jinbo Hu
Aldosterone-to-renin ratio (ARR) based screening is the first step in the diagnosis of primary aldosteronism (PA). However, the guideline-recommended ARR cutoff covers a wide range, from the equiva...
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The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-01-24 Yue Yuan, Jing Shi, Wei Sun, Xiangqing Kong
The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chin...
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Research hotspots and trends regarding microRNAs in hypertension: a bibliometric analysis Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2024-01-17 Yu Sun, Qingxin Shang
To investigate the research levels, hotspots, and development trends regarding microRNAs in hypertension, this study conducted a visual analysis of studies on miRNA in hypertension based on the Web...
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Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-12-26 Cong Lan, Guangyao Fang, Chenming Qiu, Xiuchuan Li, Fengyuan Yang, Yongjian Yang
Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-s...
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The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-27 Jiangyong Yang, Guojun Jiang, Ling Huang, Zhongyi Liu, Rengui Jiang, Gang Cao, Jun Cao, Hengqing Zhu, Lemei Chen, Xiaoming Chen, Fang Pei
Long non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncR...
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Baseline and longitudinal cardiovascular health using Life’s Essential 8 metrics with the risk of incident hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-20 Xue Tian, Jingxuan Feng, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Penglian Wang, Shouling Wu, Anxin Wang
The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the “Life’s Essential 8” (LE8) score. We aimed to investigate the associations of b...
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Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-16 Luxun Tang, Qi Cai, Xiao Wang, Xiaoyu Li, Xiuchuan Li, Lianglong Chen, Yongjian Yang
Pulmonary arterial hypertension (PAH) is a disease with a high mortality and few treatment options to prevent the development of pulmonary vessel remodeling, pulmonary vascular resistance, and righ...
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CircUsp9x/miR-599/stim1 axis regulates proliferation and migration in vascular smooth muscle cells induced by oxidized-low density lipoprotein Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-14 Hui-Lin Hu, Hui-Xiu Zheng, Na Yuan, Chang-Lin Zhai, Hao Chen, Hai-Hua Pan, Gang Qian
Circular RNAs (circRNAs) regulate the function of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) progression. We aimed to explore the role of circUSP9X in oxidized low-density lipopro...
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Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-14 Hanwen Liu, Yanwen Li, Maogang Li, Linghai Xie, Feng Li, Runmei Pan, Fang Pei
Endothelial dysfunction is a critical initiating factor in the development of hypertension and related complications. Follistatin-like 1 (FSTL1) can promote endothelial cell function and stimulates...
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Calcitriol reverses age-related hypertension via downregulating renal AP1/AT1R pathway through regulating mitochondrial function Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-08 Ruifang Hua, Baixiong Liu, Wenxiu He, Huilin Zhang, Yong Liu, Qiang Xie, Linjun Zhou, Fang Pei
The vitamin D level in the blood is associated with the incidence of hypertension. The present study investigated whether or not calcitriol, an active form of vitamin D, reverses age-related hypert...
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Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na+ excretion and insulin resistance Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-11-09 Xiaoxin Zhou, Longlong Zhang, Xiaoqian Lin, Xi Chen, Hong Liu, Xiaoli Yuan, Qiuxia Zhao, Weiwei Wang, Xun Lei, Pedro A Jose, Chunyan Deng, Jian Yang
Thrombospondins (TSPs) play important roles in several cardiovascular diseases. However, the association between circulating (plasma) thrombospondin 2 (TSP2) and essential hypertension remains uncl...
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TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-30 Jie Pang, Linyan Qian, Xiaoru Che, Ping Lv, Qiang Xu
The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship...
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CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-29 Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong
Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and splic...
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RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-25 Sheng Hu, Yijie Zhang, Chenming Qiu, Ying Li
Objective: Excessive proliferation and migration of pulmonary arterial smooth muscle cell (PASMC) is a core event of pulmonary hypertension (PH). Regulators of G protein signaling 10 (RGS10) can re...
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Visceral fat and its dynamic change are associated with renal damage: Evidence from two cohorts Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-23 Mengyue Lin, Shiwan Wu, Xiulian Deng, Yequn Chen, Xuerui Tan
To evaluate the association of Chinese visceral adiposity index (CVAI) and its dynamic trends with risk of renal damage, and to compare its prediction performance with that of other obesity indices...
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Associations between central pulse pressure, microvascular endothelial function, and fluid overload in peritoneal dialysis patients Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-16 Seoyon Koh, Seung-Jung Kim, Shina Lee
Microcirculatory endothelial dysfunction is a complex phenomenon that contributes to the development of cardiovascular disease. However, the relationship between microcirculatory endothelial dysfun...
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MG53 alleviates hypoxia/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-17 Yan Wang, Hongying Zhou, Jin Wu, Shanshan Ye
Mitsugumin 53 (MG53) is a membrane repair factor that is associated with acute myocardial infarction. This study aimed to investigate the effects of MG53 on cardiomyocyte injury and the posttransla...
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TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-10 Ying Wang, Min Xia, Jincheng Lu, Tianyu Wang, Xuan Zhang, Michael Ntim, Bin Wang
Hypertension is well-known to be influenced by genetic and environmental factors. Managing stress is one of the non-pharmacologic approaches to treating hypertension. It is, therefore, imperative t...
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Accumulated exposure to high non-high-density lipoprotein cholesterol increases the risk of cardiovascular diseases in hypertensive individuals: An 11-year prospective cohort study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-08 Weiqiang Wu, Yanjuan Chen, Kuangyi Wu, Huancong Zheng, Guanzhi Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen
The relationship of cumulative non high-density lipoprotein-cholesterol (Cum-non-HDL-C) concentration with the risk of cardiovascular disease (CVD) in individuals with hypertension remains unclear....
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Body roundness index improves the predictive value of cardiovascular disease risk in hypertensive patients with obstructive sleep apnea: a cohort study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-10-08 Xintian Cai, Shuaiwei Song, Junli Hu, Qing Zhu, Wenbo Yang, Jing Hong, Qin Luo, Xiaoguang Yao, Nanfang Li
Obesity, especially visceral obesity, plays an important role in the progression of cardiovascular disease (CVD). The body roundness index (BRI) is a new measure of obesity that is considered to re...
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Mediating effect of subclinical inflammation on the process of morning hypertension leading to atrial fibrillation in community-based older adults Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-08-31 Jinping Li, Zhibo Hu, Liming Hou, Peilin Li, Ruizhen Yang, Yuanli Dong, Hua Zhang, Yuqi Guo, Weike Liu, Zhendong Liu
ABSTRACT Background The impacts and mechanisms of morning hypertension (MHT) on the risk of new-onset atrial fibrillation (AF) in the elderly have not been clarified. We aimed to investigate an association between MHT and new-onset AF and explore a mediating effect of subclinical inflammation on this association. Methods From 2008 to 2010, 1789 older adults aged ≥60 years were recruited in Shandong
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Effect of GRK4 on renal gastrin receptor regulation in hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-08-29 Xuewei Xia, Yongchun Zeng, Zhuxin Li, Hao Luo, Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen, Xiang Xu
ABSTRACT Objective To investigate whether GRK4 regulates the phosphorylation and function of renal CCKBR. Methods GRK4 A142V transgenic mice were used as an animal model of enhanced GRK4 activity, and siRNA was used to silence the GRK4 gene to investigate the regulatory effect of GRK4 on CCKBR phosphorylation and function. Finally, the co-localization and co-connection of GRK4 and CCKBR in RPT cells
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A propensity score matched comparison of blood pressure lowering in essential hypertension patients treated with antihypertensive Chinese herbal Medicine: comparing the real-world registry data vs. randomized controlled trial Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-08-28 Xinxing Lai, Zhenghao Fang, Zhenyu Dong, Shengxian Wu, Xiaohua Zhou, Ying Gao
ABSTRACT Background Randomized controlled trials have demonstrated that Songling Xuemaikang capsule (SXC) is effective in blood pressure (BP) lowering for essential hypertension. However, the effectiveness of SXC in real-world clinical practice remains unknown. We aimed to investigate whether the BP-lowering effectiveness of SXC in the real-world practice setting is comparable to the efficacy of the
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Comprehensive viewpoints on heart rate variability at high altitude Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-08-08 Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
ABSTRACT Objectives Hypoxia is a physiological state characterized by reduced oxygen levels in organs and tissues. It is a common clinicopathological process and a major cause of health problems in highland areas. Heart rate variability (HRV) is a measure of the balance in autonomic innervation to the heart. It provides valuable information on the regulation of the cardiovascular system by neurohumoral
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Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-08-08 Liu Qin, Yanling Ren, Lan Chen, Ye Feng, Shunqing Luo, Ping Zhang, Wei Zhang, Xiaohua Liang
ABSTRACT Background Although nuts play an important role in preventing cardiovascular disease, the metabolic cues by which nuts regulate blood pressure have not been fully understood.Aims:We conducted a nested case–control study in a prospective cohort study of Southwest China children to explore the potential lipid metabolites related to the relationship between nut dietary and blood pressure. Methods
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Influence of blood pressure variations during hemodialysis on the prognosis of dialysis patients Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-28 Yuko Ohta, Masayo Fukuhara, Ritsuko Fujisawa, Maki Kanesaki, Hiroshi Tsuruta, Hidetoshi Nakamura, Yuhei Kawano
ABSTRACT The prognosis of dialysis patients is poorer than that of the general population. The relationship between dialysis patients’ blood pressure (BP) and mortality is controversial. We investigated the relationships between mortality and (i) pre-dialysis BP and (ii) BP variation during hemodialysis in maintenance dialysis patients. We retroactively analyzed the cases of the 284 patients on hemodialysis
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Prognostic implications of machine learning-derived echocardiographic phenotypes in community hypertensive patients Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-21 Anping Cai, Zhou Dan, Yingling Zhou, Yinqing Feng, Zhiqiang Nie
ABSTRACT Background Echocardiogram is commonly used to evaluate cardiac remodeling in hypertension (HTN). However, study on echocardiographic phenotypes and their prognostic implications in HTN is limited. Objective We aimed to evaluate the prognostic implications echocardiographic phenotypes in community hypertensive patients. Method A total of 1881 community hypertensive patients without overt cardiovascular
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Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-16 Chunmei Xu, Jun Zhu, Guangyuan Gong, Li Guo, Ye Zhang, Ziyue Zhang, Chunlan Ma
ABSTRACT Background Anthocyanin plays a protective role in cardiovascular disease through antioxidant effect. Whether anthocyanin can reduce salt-induced hypertension and the related mechanisms remain unclear. Methods Chronic infusion of vehicle (artificial cerebrospinal fluid, aCSF, 0.4 μL/h) or anthocyanin (10 mg/kg, 0.4 μL/h) into bilateral paraventricular nucleus (PVN) of Sprague-Dawley rats was
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Association between composite dietary antioxidant index and hypertension: insights from NHANES Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-13 Mingyue Wu, Jiayi Si, Yihai Liu, Lina Kang, Biao Xu
ABSTRACT Aim The association between composite dietary antioxidant index (CDAI) and hypertension remains unknown. Our study was to investigate the association of CDAI with hypertension in general adults. Methods A total of 21 526 participants were enrolled from the National Health and Nutrition Examination Surveys (NHANES). The CDAI was calculated from the intake of six dietary antioxidants. Multivariable
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Ginsenoside Rh2 mitigates myocardial damage in acute myocardial infarction by regulating pyroptosis of cardiomyocytes Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-03 Hong Peng, Li Chen, Yi Deng, Xin Liao, Yi Yang
ABSTRACT Background Acute myocardial infarction (AMI) is one of the most important causes of mortality among patients with cardiovascular disease. Ginsenoside Rh2 plays a protective role in cardiovascular diseases. Furthermore, pyroptosis reportedly participates in regulating the occurrence and development of AMI. However, whether ginsenoside Rh2 contributes to mitigating AMI by regulating cardiomyocyte
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Ketogenic diet inhibits neointimal hyperplasia by suppressing oxidative stress and inflammation Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-07-03 Xuefei Xu, Limin Xie, Lili Chai, Xiaoming Wang, Jinhu Dong, Jipei Wang, Pengwei Yang
ABSTRACT Objective Neointimal hyperplasia is the primary mechanism underlying atherosclerosis and restenosis after percutaneous coronary intervention. Ketogenic diet (KD) exerts beneficial effects in various diseases, but whether it could serve as non-drug therapy for neointimal hyperplasia remains unknown. This study aimed to investigate the effect of KD on neointimal hyperplasia and the potential
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Relationship between ambulatory arterial stiffness index and the severity of angiographic atherosclerosis in patients with H-type hypertension and coronary artery disease Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-26 Li Dong, Jing Liu, Yan Qin, Wen-Juan Yang, Liang Nie, Hua-Ning Liu, Qing-Hua Hu, Yu Sun, Wen-Yan Cao
ABSTRACT Objective To investigate coronary artery disease (CAD) and its correlation with the ambulatory arterial stiffness index (AASI) in patients with H-type hypertension (essential hypertension combined with hyper-homocysteinemia) and coronary heart disease (CHD). Methods Patients with essential hypertension and CHD who were undergoing coronary angiography were enrolled. The general clinical data
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Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-27 Jiule Ding, Jie Chen, Jun Zhou, Zhenxing Jiang, Dehui Xiang, Wei Xing
ABSTRACT Objective To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension. Methods This cross-sectional study included patients with arterial hypertension aged 18–60 years who underwent contrasted computed tomography (CT) of kidney from January 2012 to December 2020. The subjects were classified into AVE
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The relationship between circadian rhythm of blood pressure and vascular dysfunction in essential hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-26 Yancui Sun, Ying Zhang, Fei Liu, Xiaojie Liu, Tesfaldet H. Hidru, Xiaolei Yang, Yinong Jiang
ABSTRACT Objective This study aimed to explore whether circadian rhythm of blood pressure is associated with brachial-ankle pulse wave velocity (baPWV) and brachial artery flow-mediated dilation (FMD) in patients with essential hypertension. Method This cross-sectional study included 4,217 patients with essential hypertension who completed 24-hour ambulatory blood pressure monitoring, baPWV, and FMD
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Determinants of self-rated health among elderly patients with hypertension: a cross-sectional analysis based on the Chinese longitudinal healthy longevity survey Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-20 Yang Zhou, Yanjing Huang, Aohua Zhang, Guige Yin, Hongjuan Hu
ABSTRACT Background The total number of elderly patients with hypertension in China has been increasing year by year, it is necessary to adopt simple and valid measures to evaluate the health status of elderly patients with hypertension to reduce the heavy burden faced by this group. Method This study is a cross-sectional analysis. Participants aged at least 65 years were included. Self-Rated Health
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Seasonal variation in diurnal blood pressure pattern Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-20 Xinyue Du, Lingli Wang, Wenyi He, Xin Fu, Yingjiao Zhang, Wei Zhou, Yuying Han, Guolan Deng
ABSTRACT Aims To explore the relationship between diurnal blood pressure (BP) pattern and season. Methods A total of 6765 eligible patients (average age 57.35 ± 15.53 years; male 51.8%; hypertensives 68.8%) from 1 October 2016 to 6 April 2022 were enrolled, who were divided into four dipper groups, dipper, non‐dipper, riser, and extreme‐dipper, according to the diurnal BP pattern calculated using their
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The Impact of Timing of Fixed Dose Triple Antihypertensive Combinations on Ambulatory Blood Pressure Monitoring Parameters Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-20 Cigdem Ileri, Zekeriya Dogan, Beste Ozben, Latife Bircan, Aycan Acet, Taner Sen
ABSTRACT Introduction Re-establishing “dipping” physiology significantly reduces cardiovascular events. The aim was to investigate the effect of timing of fixed dose triple antihypertensive combinations on blood pressure (BP) control. Methods One hundred sixteen consecutive patients (62.7 ± 10.7 years, 38 men) with grade II hypertension were randomized into four groups. Group 1 and Group 2 patients
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Central Venous Catheter as a Novel Approach to Postoperative Thrombolysis in Patients with Acute Iliofemoral Deep Venous Thrombosis Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-06-16 Biyun Teng, Fenghe Li, Xuehu Wang, Hao Tian, Yu Zhao, Qiu Zeng
ABSTRACT Background and aims Percutaneous mechanical thrombectomy (PMT) along with postoperative thrombolysis (POT) has been the standard treatment for acute iliofemoral deep venous thrombosis (IFDVT). However, commonly used catheter directed thrombolysis (CDT) approaches for POT carry certain disadvantages, including the need for a sheath, inferior comfortability, and catheter-related complications
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MicroRNA-98 inhibition accelerates the development of atherosclerosis via regulation of dysfunction of endothelial cell Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-15 Huai Yu, Hui Cao, Hang Yu
ABSTRACT Background Atherosclerosis has been recognized as a chronic inflammation initiated by dysfunction of endothelial cell that contributes to the increased morbidity and mortality of severe cardiovascular events. The reported important role of microRNA-98 (miR-98) in regulation of endothelial cell behaviors prompt us to hypothesize that miR-98 could be involved in the process of atherosclerosis
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Sestrin2 levels in patients with anxiety and depression myocardial infarction was up-regulated and suppressed inflammation and ferroptosis by LKB1-mediated AMPK activation Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-15 Yufeng Qian, Lian Chen, Beibei Gao, Xianhua Ye
ABSTRACT Although great progress has been made in the diagnosis and treatment of acute myocardial infarction (AMI) in recent years, its morbidity and mortality are still relatively high. In this study, we explain that the function of Sestrin2 gene in Anxiety and Depression Myocardial infarction and its possible mechanism. 26 patients with Anxiety and Depression Myocardial infarction (ADMI) and 26 normal
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Neutrophil and monocyte ratios to high-density lipoprotein cholesterol as biomarkers in non-dipping hypertension Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-10 Yaqin Zhang, Yanju Ding, Wen Jiang
ABSTRACT Objective To investigate the level and significance of neutrophils to high-density lipoprotein cholesterol ratio (NHR) and monocytes to high-density lipoprotein cholesterol ratio (MHR) in patients with non-dipping hypertension. Methods A total of 228 patients were retrospectively enrolled in the study. They were divided into the dipping hypertension group (n = 76), the non-dipping hypertension
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Age, creatinine, and ejection fraction (ACEF) score as predictive values for late non-valvular atrial fibrillation recurrence after radiofrequency ablation Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-09 Yan Luo, Yan Tang, Wenchao Huang, Shiqiang Xiong, Yu Long, Hanxiong Liu
ABSTRACT The clinical risk factors associated with late recurrence in patients with non-valvular atrial fibrillation (AF) (NVAF) undergoing radiofrequency catheter ablation (RFCA) remain unknown. Furthermore, the current prognostic risk score system is commonly used in such patients as a noninvasive method to assess late AF recurrence. According to recent research, the Age, creatinine, and ejection
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Folic acid enhances the cardiovascular protective effect of amlodipine in renal hypertensive rats with elevated homocysteine Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-08 Li Li, Xiaohui Tong, Zebin Ma, Lei Lv, Haipeng Liu, Guang Liang Chen
ABSTRACT Objectives To investigate the actions of amlodipine-folic acid (amlodipine-FA) preparation on hypertension and cardiovascular in renal hypertensive rats with hyperhomocysteinemia (HHcy), so as to provide experimental basis for clinical research of amlodipine folic acid tablets. Methods Rats model of renal hypertension with HHcy were established. The rats were randomly divided into groups of
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Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-08 Yongxin Liu, Chunping Xu, Yuqing Wang, Caiting Yang, Genyuan Pu, Le Zhang, Zhuang Wang, Pengyan Tao, Shenghe Hu, Mingming Lai
ABSTRACT Objective Hypertension is one of the leading causes of human death and disability. MTHFR and MTRR regulate folate metabolism and are closely linked to hypertension, although the relationship is inconsistent among different ethnic groups. The present study aims to investigate the effects of MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), and MTRR A66G (rs1801394) polymorphisms on hypertension
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Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-07 Juan Deng, Yuan Hu, Yindi Zhang, Fadong Yu
ABSTRACT Background Endothelial dysfunction is a major pathophysiology observed in hypertension. Ghrelin, a key regulator of metabolism, has been shown to play protective roles in cardiovascular system. However, whether it has the effect of improving endothelial function and lowering blood pressure in Ang II-induced hypertensive mice remains unclear. Methods In this study, hypertension was induced
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FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-08 Kun Jiao, Ping Su, Yongling Li
ABSTRACT Background Fibroblast growth factor receptor (FGFR)2 expression was decreased in hypertension patients while its role in hypertension was not explored. This experiment aimed to investigate the expression ofFGFR2 in angiotensin II (Ang II)-induced human umbilical vein endothelial cells (HUVECs) and the role of FGFR2 in improving AngII-induced hypertension-related endothelial dysfunction. Methods
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Inhibition of endoplasmic reticulum stress restores the balance of renal RAS components and lowers blood pressure in the spontaneously hypertensive rats Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-05 Jun Zhu, Anjing Shao, Chunyan Wang, Chensi Zeng, Hongyong Wang
ABSTRACT Background Endoplasmic reticulum (ER) stress has been shown to play a critical role in the pathogenesis of hypertension. However, the underlying mechanisms for lowering blood pressure (BP) by suppressing ER stress remain unclear. Here, we hypothesized that inhibition of ER stress could restore the balance between RAS components and lower BP in spontaneously hypertensive rats (SHRs). Methods
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Inflammation is associated with incident hypertension in patients with axial spondyloarthritis: A longitudinal cohort study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-05-04 Lin-Hong Shi, Steven H. Lam, Ho So, Crystal Y. Chan, Tena K. Li, Cheuk-Chun Szeto, Lai-Shan Tam
ABSTRACT Objectives To elucidate the risk factors for the development of incident hypertension (IHT) in patients with axial spondyloarthritis (axSpA). Methods We conducted a retrospective cohort study in axSpA patients who were recruited from 2001 to 2019 from a university clinic in Hong Kong. Patients with HT and/or anti-hypertensive drug use at baseline were excluded. They were followed until the
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Effect of blood pressure variability on hypertensive retinopathy Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-04-30 Lei Jiao, Chaoran Lv, Hongling Zhang
ABSTRACT Purpose This study intends to investigate the correlation between blood pressure variability (BPV) levels and the use of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to measure retinal microvasculature in hypertensive patients. Methods All individuals in the study had 24-hour ambulatory blood pressure monitoring and bilateral OCT and OCTA exams, and
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Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-04-30 Wenhai Guo, Danping Huang, Shaodong Li
ABSTRACT Background and objective: Epidemiological research have displayed that dietary intake rich in lycopene, an antioxidant, is negatively correlated with the risk of cardiovascular disease (CVD). This study aimed to investigate whether the intervention with different concentrations of lycopene could attenuate H2O2-induced oxidative stress injury in human vascular endothelial cells (VECs). Methods:
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What is the prevalence of chronic kidney disease among hypertensive non-diabetic Egyptian patients attending primary healthcare? Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-04-23 Silvana Nader Nagib, Saeed Abdelwahab, Ghada Essam El-Din Amin, Mohamed Farouk Allam
ABSTRACT Background Although chronic kidney disease (CKD) is considered the major cause of morbidity and mortality in hypertension, the recognition and prevention of CKD remain deficient. CKD is one of the major health challenges in Egypt. CKD affects approximately 13% of the adult population, resulting in significant morbidity, mortality, and health care costs. Patients with more progressive stage
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Brachial-ankle pulse wave velocity as a risk factor for high body fat mediated by blood pressure Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-04-04 Ping Wang, Guihua Liao, Xi Wu, Rentao Yu, Jun Ma
ABSTRACT Background Brachial-ankle pulse wave velocity (baPWV) is an important clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease and associated with obesity. However, whether body mass index (BMI) is associated with baPWV remains controversial. In our study, body fat-related indicators, including BMI, body fat rate (BFR), body fat volume (BFV), waist circumference
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Gut microbiota and hypertension: association, mechanisms and treatment Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-03-30 Zhihua Yang, Qingchun Wang, Yangxi Liu, Lin Wang, Zhao Ge, Zhenzhen Li, Shaoling Feng, Chongming Wu
ABSTRACT Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular diseases, which brings a heavy economic burden to society and becomes a major public health problem. At present, the pathogenesis of hypertension is unclear. Increasing evidence has proven that the pathogenesis of hypertension is closely related to the dysbiosis of gut microbiota. We briefly reviewed
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Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-03-30 Qianglin Yi, Hui Hu, Qingfan Zeng
ABSTRACT Background It has been reported that there is a close correlation between triglycerides to high density lipoprotein cholesterol ratio (TG/HDL-C) and hypertension, but there are differences between different researches. The purpose of this study is to investigate the relationship between TG/HDL-C and hypertension in Chinese adults. Methods In this study, the open data for secondary analysis
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Hirsutine ameliorates myocardial ischemia-reperfusion injury through improving mitochondrial function via CaMKII pathway Clin. Exp. Hypertens. (IF 12.3) Pub Date : 2023-03-23 Wen Jiang, Yuxiang Zhang, Wei Zhang, Xiaomei Pan, Jieyu Liu, Qiang Chen, Junhui Chen
ABSTRACT Acute myocardial infarction (AMI) is the leading cause of death worldwide. Ischemia-reperfusion (I/R) injury is considered the most common contributor to AMI. Hirsutine has been shown to protect cardiomyocytes against hypoxic injury. The present study investigated whether hirsutine improved AMI induced by I/R injury and the underlying mechanisms. In our study, we used a rat model of myocardial