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Epidemiology and Risk Factors for Orthostatic Hypotension and Its Severity in Residents Aged > 60 years: A Cross-Sectional Study Int. J. Hypertens. (IF 1.9) Pub Date : 2024-2-27 Mingni Yang, Ruiqiang Peng, Zetuo Wang, Miaoduan Li, Yehua Song, Jianping Niu, Yong Ji
This cross-sectional study investigated the epidemiology and risk factors associated with orthostatic hypotension (OH) and its severity in older adults residing in the Jizhou community of Tianjin and the Jimei community of Xiamen. The study, conducted from March to September 2019, involved adults aged over 60. A comprehensive questionnaire survey was administered, resulting in the enrolment of 4383
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents Int. J. Hypertens. (IF 1.9) Pub Date : 2024-2-19 undefined Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani
The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis. Various LBDDSs verified to be an efficacious mechanism for monitoring hypertension systems are SEDDS (self-nano emulsifying drug delivery),
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Platelet Indices and Hypertension: Results from Shahedieh Cohort Study, Yazd, Iran Int. J. Hypertens. (IF 1.9) Pub Date : 2024-2-13 Fateme Shakeri Shamsi, Moslem Taheri Soodejani
Introduction. Hypertension is one of the most important diseases worldwide. In this study, we aim to demonstrate the relationship between platelet indices and hypertension. Materials and Methods. We studied 9448 people in the age range of 30 to 70 years. We assessed their hypertension status, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), smoking, cardiovascular
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Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats Int. J. Hypertens. (IF 1.9) Pub Date : 2024-2-2 Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan
Background. Da-Chuan-Xiong Decoction (DCXD) is an aqueous extract from a classic Chinese herbal formula composed of dried rhizomes of Ligusticum chuanxiong Hort and Gastrodia elata Bl. in the mass ratio of 4 : 1. It has been long used to treat chronic cardiovascular disease caused by blood stasis and wind pathogen in the clinic. This experimental study aimed to investigate the blood pressure (BP)-lowering
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Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population Int. J. Hypertens. (IF 1.9) Pub Date : 2024-1-23 Huixia Liu, Hua Zhong, Ying Lin, Linzhi Han, Mengshi Chen, Tao Tang, Jing Deng
Background. Antihypertensive therapy is crucial for preventing stroke in hypertensive patients. However, the efficacy of antihypertensive therapy varies across individuals, partially due to therapy-related genetic variations among individuals. We investigated the association of antihypertensive drug-related gene polymorphism with stroke in patients with hypertension. Methods. Demographic information
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The Link between Overweight/Obesity and Noncommunicable Diseases in Ethiopia: Evidences from Nationwide WHO STEPS Survey 2015 Int. J. Hypertens. (IF 1.9) Pub Date : 2023-11-16 Bedilu Alamirie Ejigu, Fentanesh Nibret Tiruneh
Background. Noncommunicable diseases (NCDs) are the leading cause of death worldwide. Each year, 15 million adults die from NCDs; more than 85% of these premature deaths occur in low- and middle-income nations. Evidence indicates that overweight and obesity are the main risk factors for NCDs. Although the literature indicates that the burden of NCDs is increasing in Ethiopia, no research has been conducted
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Preliminary Consequences of Blood Pressure Management and Blood Homocysteine Levels with Perindopril in Newly Diagnosed Hypertensive Patients in the Vietnamese Population Int. J. Hypertens. (IF 1.9) Pub Date : 2023-10-18 Son Kim Tran, An Bao Truong, Phi Hoang Nguyen, Toan Hoang Ngo, Tuyen Long Vu, Khoa Dang Dang Tran, Phuong Minh Vo, Bao The Nguyen, Tuong Le Trong Huynh, Kien Trung Nguyen, Hung Do Tran
Background. Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction. Objectives. Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension. Materials and Methods. A cross-sectional descriptive study with a longitudinal follow-up was conducted on 105 primary hypertensive
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Prevalence of Hypertension and Associated Factors among Residents Aged ≥18 Years in Ganzhou, China: A Cross-Sectional Study Int. J. Hypertens. (IF 1.9) Pub Date : 2023-10-5 Junwang Gu, Qi Wang, Wei Qiu, Fen Lin, Chunmei Wu, Ming Hao, Ping Wu
Background. Reliable epidemiologic data on the present burden of hypertension are needed in developing region-specific strategies since previous studies have suggested that China is lagging in risk factor management. Objective. The study aimed at exploring the prevalence of hypertension and its associated factors among adult residents in Ganzhou, China. Methodology. A multistage, stratified, and cluster
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Evaluation of Mean Platelet Volume in Children with Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2023-9-21 Ismail Yildiz, Ozgur Kizilca
Background. Childhood hypertension, a disease with increasing prevalence, can lead to severe health problems. With the increased pressure on the vascular endothelium in hypertension, lesions in the endothelium result in endothelial activation and a process of inflammation, which causes platelet activation and in the bone marrow the release of platelet precursor cells into the peripheral blood stream
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Covariates of Knowledge, Attitude, Practice, and Burdens among the Caregivers of Hypertensive Patients Int. J. Hypertens. (IF 1.9) Pub Date : 2023-8-21 Sudipta Deb Nath, Afrin Sultana Chowdhury, Susmita Dey Pinky, Kazi Mahmuda Akter, Nishat Anjum Nourin, Tonmoy Chowdhury, Hossain Ahmed Fahid, K. M. Shailah Sharmin, Md. Mashud Rana, Nazmul Alam, Md. Moinul Ahsan, Adnan Mannan
Caregivers of hypertensive patients play a significant role in ensuring adequate patient care and lowering the risk of hypertension-relatedcomplications. Caregivers are ideal study subjects for identifying gaps in hypertension management. Our study aimed to assess the knowledge, attitude, and practice (KAP) of hypertensive patients’ caregivers, to identify their extent of involvement in patients’ care
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miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding Int. J. Hypertens. (IF 1.9) Pub Date : 2023-7-20 Juan Wen, Baiyi Tang, Lan Guo, Wei Chen, Xiaohong Tang
It has been shown that miR-145 is involved in the differentiation of vascular smooth muscle cells (VSMCs) and may regulate vascular remodeling. However, the molecular mechanisms behind these pathological processes in hypertension are not fully elucidated. The present study was to examine whether miR-145 modulates phenotypic transformation of VSMCs under normal state and synthetic state and to explore
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Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans Int. J. Hypertens. (IF 1.9) Pub Date : 2023-5-30 Jonathan N. Katsukunya, Nyarai D. Soko, Jashira Naidoo, Brian Rayner, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Michelle Dandara, Kevin Dzobo, Erika Jones, Collet Dandara
In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current hypertension guidelines recommend the use of antihypertensives belonging to the following classes: calcium channel blockers (CCB), angiotensin
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Comorbidity of Anxiety and Hypertension: Common Risk Factors and Potential Mechanisms Int. J. Hypertens. (IF 1.9) Pub Date : 2023-5-25 Tingting Qiu, Zhiming Jiang, Xuancai Chen, Yehua Dai, Hong Zhao
Anxiety is more common in patients with hypertension, and these two conditions frequently coexist. Recently, more emphasis has been placed on determining etiology in patients with comorbid hypertension and anxiety. This review focuses on the common risk factors and potential mechanisms of comorbid hypertension and anxiety. Firstly, we analyze the common risk factors of comorbid hypertension and anxiety
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Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2023-5-9 Tiar Masykuroh Pratamawati, Idrus Alwi, undefined Asmarinah
Hypertension is a multifactorial disease due to a complex interaction among genetic, epigenetic, and environmental factors. Characterized by raised blood pressure (BP), it is responsible for more than 7 million deaths per annum by acting as a leading preventable risk factor for cardiovascular disease. Reports suggest that genetic factors are estimated to be involved in approximately 30 to 50% of BP
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Intensive Blood Pressure Control and Diabetes Mellitus Incidence for Patients with Impaired Fasting Glucose: A Secondary Analysis of SPRINT Int. J. Hypertens. (IF 1.9) Pub Date : 2023-3-16 Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan
Background. Previous studies indicated that intensive blood pressure (BP) control (systolic BP < 120 mm·Hg) compared with standard BP control (<140 mm·Hg) was associated with an increased risk of type 2 diabetes (T2D) and impaired fasting glucose (IFG) among hypertensive patients with normoglycemia. However, the impact of intensive BP control on the incidence of T2D for those with IFG is still unknown
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Ethnicity Disparities in the Prevalence, Awareness, Treatment, and Control Rates of Hypertension in China Int. J. Hypertens. (IF 1.9) Pub Date : 2023-3-14 Yanan Yang, Kunlin He, Yuewen Zhang, Xiuming Wu, Weizhong Chen, Dongqing Gu, Ziqian Zeng
Objectives. Previous studies reported that there were disparities in hypertension management among different ethnic groups, and this study aimed to systematically determine the prevalence, awareness, treatment, and control rates of hypertension in multiple Chinese ethnic groups. Methods. We searched Embase, PubMed, and Web of Science for articles up to 25 October, 2022. The pooled prevalence, awareness
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Efficacy and Safety of Eplerenone for Treating Chronic Kidney Disease: A Meta-Analysis Int. J. Hypertens. (IF 1.9) Pub Date : 2023-3-9 Honglei Hu, Mengdie Cao, Yao Sun, Xingqian Jin, Xiaodong Zhao, Xiangguo Cong
Background. In recent years, a large amount of clinical evidence and animal experiments have demonstrated the unique advantages of mineralocorticoid receptor antagonists (MRA) for treating chronic kidney disease (CKD). Aims. Accordingly, the present study aimed to systematically assess the second-generation selective MRAs eplerenone’s safety and effectiveness for treating CKD. Methods. Four databases
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Positive Association between Hemoglobin Concentration and Blood Pressure in Adults: A Cross-Sectional Study Based on Rafsanjan Cohort Study Int. J. Hypertens. (IF 1.9) Pub Date : 2023-2-1 Gholamreza Bazmandegan, Mitra Abbasifard, Hamid Ostadebrahimi, Mohammadreza Gholamrezapour, Zahra Kamiab
Introduction. Identification of factors associated with blood pressure (BP), including hemoglobin, can be used in diagnosing, controlling, and predicting the prognosis of patients. This study aims to investigate the cross-sectional association between hemoglobin concentration and BP in people aged 35–70 years in a cohort study of Rafsanjan, Iran. Method. This cross-sectional study was conducted on
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Evaluation of Arterial Stiffness and Its Relation to Innovative Anthropometric Indices in Persian Adults Int. J. Hypertens. (IF 1.9) Pub Date : 2023-1-23 Zahra Ataee, Atena Aghaee, Seyyed Reza Sobhani, Elaheh Ebrahimi Miandehi, Parisa Pirzadeh, Maryam Alinezhad-Namaghi, Saeid Eslami, Sahar Sobhani
Background. BMI has been evaluated as an old criterion to evaluate obesity in individuals, but it does not assess abdominal obesity and lean mass. We aimed to evaluate the possible relationship of new anthropometric indices (namely, a body shape index (ABSI), the body roundness index (BRI), the visceral adiposity index (VAI), the visceral fat area (VFA), and waist-hip ratio (WHR)), with one of the
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Antihypertensive Effects of Esaxerenone in Older Patients with Primary Aldosteronism Int. J. Hypertens. (IF 1.9) Pub Date : 2023-1-17 Masanori Fujimoto, Suzuka Watanabe, Katsushi Igarashi, Yutaro Ruike, Kazuki Ishiwata, Kumiko Naito, Akiko Ishida, Masaya Koshizaka, Sawako Suzuki, Yuki Shiko, Hisashi Koide, Koutaro Yokote
Context. Esaxerenone is a new mineralocorticoid receptor antagonist (MRA). It is an oral nonsteroidal MRA with high MR-binding specificity and antihypertensive effects in patients with essential hypertension and primary aldosteronism (PA). This study aimed to investigate the underlying characteristics of PA patients who responded best to an esaxerenone treatment. Design. Retrospective cohort study
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The Association between Hypertension and Insomnia: A Bidirectional Meta-Analysis of Prospective Cohort Studies Int. J. Hypertens. (IF 1.9) Pub Date : 2022-12-29 Dingwei Liu, Chao Yu, Ke Huang, Shawn Thomas, Wei Yang, Song Liu, Jie Kuang
Background. Studies on bidirectional associations between hypertension and insomnia are inconclusive. The purpose of this meta-analysis was to systematically review and summarize the current evidence from epidemiological studies that evaluated this relationship. Materials and Methods. PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wan Fang, and VIP databases were searched for studies
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Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-12-8 Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Guoqiang Gu, Wei Cui
Background. Hypertension poses a major threat to human health, and inflammation is associated with hypertension. The monocyte to high-density lipoprotein cholesterol ratio (MHR) represents a new inflammatory indicator. However, the relationship between the MHR and hypertension remains unclear. The present study investigated the association of MHR with hypertension. Method. For this cross-sectional
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Prevalence and Clinical Characteristics including Patterns of Antihypertensive Drug Administration of the Different Home Blood Pressure Phenotypes in Treated Hypertensive Patients Int. J. Hypertens. (IF 1.9) Pub Date : 2022-12-8 Chavalit Chotruangnapa, Tossaporn Thammarux, Piyawan Thongdang
Quality and quantity of home blood pressure (BP) control are important for optimizing hypertensive treatment. The prevalence and associated clinical characteristics of the different home blood pressure phenotypes in treated hypertensive patients were not elucidated. This study was conducted in Siriraj Hospital, Thailand from 2019 to 2020. We included treated hypertensive patients with ≥1 antihypertensive
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Mortality Rate and Years of Life Lost due to Hypertension in the South of Iran between 2004 and 2019: A Population-Based Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-11-29 Alireza Mirahmadizadeh, Mohebat Vali, Jafar Hassanzadeh, Seyed Parsa Dehghani, Ahmadreza Razeghi, Habibollah Azarbakhsh
Introduction. Hypertension is known worldwide as a preventable significant risk factor for cardiovascular diseases and their mortality. This study was designed to determine the mortality rate and years of life lost (YLL) due to hypertension in Fars Province. Method. In this cross-sectional study, we extracted all death reports due to hypertension based on age, gender, and the year of death based on
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Exercise-Induced Excessive Blood Pressure Elevation Is Associated with Cardiac Dysfunction in Male Patients with Essential Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2022-11-28 Binfeng Xia, Pengyu Cao, Li Zhang, Huihui Huang, Rongyu Li, Xia Yin
Objective. Cardiopulmonary exercise testing (CPET) has been used to explore the blood pressure response and potential cardiovascular system structure and dysfunction in male patients with essential hypertension during exercise, to provide a scientific basis for safe and effective exercise rehabilitation and improvement of prognosis. Methods. A total of 100 male patients with essential hypertension
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Preference for Stronger Taste Associated with a Higher Risk of Hypertension: Evidence from a Cross-Sectional Study in Northwest China Int. J. Hypertens. (IF 1.9) Pub Date : 2022-11-22 Huimeng Liu, Yutong Wang, Binyan Zhang, Yating Huo, Suixia Cao, Jingchun Liu, Lingxia Zeng, Hong Yan, Shaonong Dang, Baibing Mi
Background. Dietary modulation is a primary lifestyle approach for reducing the risk of hypertension. However, evidence of the potential role that a dietary taste preference plays in the risk of hypertension remains limited. Methods. A cross-sectional analysis was conducted based on the Shaanxi baseline survey of the Regional Ethnic Cohort Study. We used self-reported salt consumption and intensity
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Influence of AGTR1 and ABCB1 Gene Polymorphism on the Curative Effect of Irbesartan Int. J. Hypertens. (IF 1.9) Pub Date : 2022-11-9 Qiao Wang, Lingsen You, Zeyu Li, Leiyi Zhang, Xueqi Li, Xuesong Yang
The interindividual heterogeneity in response to the antihypertensive effect of irbesartan has received considerable attention because of gene polymorphism. In this study, we investigated the new combinational influences of AGTR1 and ABCB1 gene polymorphism on the therapeutic effect of irbesartan among Chinese hypertensive patients. A total of 353 samples including 168 normal people and 185 hypertensive
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Hypertensive Response to Exercise in Athletes: Unremarkable Finding or Relevant Marker for Future Cardiovascular Complications? Int. J. Hypertens. (IF 1.9) Pub Date : 2022-11-1 Laura Würzburger, Patrick Wiech, Valentina A. Rossi, Daniel Neunhäuser, Stefano Caselli, Christian M. Schmied, David Neunhäuserer
Background. In the general population, hypertensive response to exercise (HRE) predicts new-onset resting hypertension or other cardiovascular diseases. Methods. PubMed was searched for English articles published between January 1st 2000 and April 30th 2020. Additional studies were identified via reference lists of included studies. 92 papers were selected for full text analysis, finally 30 studies
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Mortality in Elderly Patients Taking Furosemide: Prospective Cohorts Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-10-29 Alejandro Rodríguez-Molinero, Antonio Miñarro, Leire Narvaiza, César Gálvez-Barrón, Natalia Gonzalo León, Esther Valldosera, Eva De Mingo, Oscar Macho, David Aivar, Efren Pinzón, Adilis Alba, Jorge Passarelli, Nadia Stasi, Isabel Collado, José R. Banegas
Objectives. Low blood pressure (BP) has been proposed as a risk factor of death in elderly patients. However, this association could be partially accounted for by the deleterious effects of BP-lowering drugs. We analyzed whether these drugs are associated to an increased risk of death in elderly patients taking multiple potential confounders into account. Design. This is a prospective cohort study
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Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China Int. J. Hypertens. (IF 1.9) Pub Date : 2022-9-26 Xin He, RuLin Ma, Yu Li, Haixia Wang, YiZhong Yan, YiDan Mao, ShengYu Liao, XueYing Sun, ShuXia Guo, Heng Guo
Objective. This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension. Method. In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and
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Syndecan-4 is More Sensitive in Detecting Hypertensive Left Ventricular Diastolic Dysfunction in 2K2C Rats Int. J. Hypertens. (IF 1.9) Pub Date : 2022-9-24 Wenyue Dai, Yanqiu Liu, Fengjuan Yao, Wei Li, Jia Liu, Cuiling Li, Donghong Liu
Objective. The aim of this study was to investigate the changes of syndecan-4 (SDC-4) during the hypertensive period in two kidney-two clip (2K2C) hypertension rats and compare them to brain natriuretic peptide (BNP) and the echocardiographic parameters for diastolic function evaluation in the rat model of 2K2C hypertension. Methods. A total of 36 Sprague–Dawley (SD) rats were used in this study. Hypertension
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Evaluation of Psychological Distress, Self-Care, and Medication Adherence in Association with Hypertension Control Int. J. Hypertens. (IF 1.9) Pub Date : 2022-08-25 Maryam Eghbali, Maedeh Akbari, Kimiya Seify, Mohammad Fakhrolmobasheri, Maryam Heidarpour, Hamidreza Roohafza, Maryam Afzali, Fateme-sadat Mostafavi-esfahani, Parisa Karimian, Anis Sepehr, Davood Shafie, Alireza Khosravi
Background. Most of the patients with hypertension (HTN) who undergo medical therapy unaccompanied by psychological and behavioral interventions may not achieve their goal in HTN treatment. Self-care is a key factor in controlling HTN. Given that depression, stress, and anxiety are the most psychological disorders in chronic illnesses. Their impact on self-care, quality of life, and HTN control must
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Predictors of Nonadherence to Medications among Hypertensive Patients in Ghana: An Application of the Health Belief Model Int. J. Hypertens. (IF 1.9) Pub Date : 2022-08-24 Fidelis Atibila, Emmanuel Timmy Donkoh, Rob Ruiter, Gerjo Kok, Gill Ten Hoor
Introduction. Hypertension (HPT) is recognized as a significant public health problem worldwide from a health and economic perspective. This study determined predictors of nonadherence to HPT medications in Ghana using the health belief model. Methods. A cross-sectional descriptive survey employing a quantitative approach was conducted among HPT patients who routinely attend clinics at selected hospitals
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Present Evidence of Determinants to Predict the Efficacy of Renal Denervation Int. J. Hypertens. (IF 1.9) Pub Date : 2022-08-12 Hao Zhou, Yanping Xu, Weijie Chen, Liang Wang, Huaan Du, Hang Liu, Zhiyu Ling, Yuehui Yin
Sympathetic overactivation is one of the main contributors to development and progress of hypertension. Renal denervation (RDN) has been evidenced by series of clinical trials for its efficacy and safety to treat overactivated sympathetic nervous system induced diseases. However, the results were inconsistent and not all patients benefited from RDN. Appropriate patient selection and intraoperative
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A Prediction Nomogram Combining Epworth Sleepiness Scale and Other Clinical Parameters to Predict Obstructive Sleep Apnea in Patients with Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2022-08-05 Lin Wang, Dongsheng Sun, Jianhong Xie, Li Zhang, Dibo Lao, Shaokun Xu
Background. Obstructive sleep apnea (OSA) is common in patients with hypertension. Nonetheless, OSA is underdiagnosed despite considerable evidence of the association between OSA and adverse health outcomes. This study developed and validated a clinical nomogram to predict OSA in patients with hypertension based on the Epworth Sleepiness Scale (ESS) score and OSA-related parameters. Methods. A total
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Trajectories of Blood Pressure in Patients with Established Coronary Artery Disease over 20 years Int. J. Hypertens. (IF 1.9) Pub Date : 2022-08-05 Piotr Jankowski, Paweł Kozieł, Grzegorz Bilo, Jarosław Pinkas, Danuta Czarnecka, Kalina Kawecka-Jaszcz, Andrzej Pająk
Objective. To evaluate changes in blood pressure (BP) values in patients with established coronary artery disease (CAD) over 20 years (1997–2017). Materials and Methods. Consecutive patients aged <71 years and hospitalized for acute coronary syndrome or myocardial revascularization procedures were recruited and interviewed 6–18 months after their discharge from the hospital. BP was measured in 1997–1998
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Electrocardiography in Hypertensive Patients without Cardiovascular Events: A Valuable Predictor Tool? Int. J. Hypertens. (IF 1.9) Pub Date : 2022-07-21 J. Ricardo Pires, M. Teixeira, F. Ferreira, I. Viseu, V. Afreixo, C. Neves
Background. Hypertension is an important risk factor of cardiovascular (CV) disease. An early diagnosis of target organ damage could prevent major CV events. Electrocardiography (ECG) is a valuable clinical technique, with wide availability and high specificity, used in evaluation of hypertensive patients. However, the use of ECG as a predictor tool is controversial given its low sensitivity. This
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Blood Pressure Trajectories for 16 Years and the Development of Left Ventricular Hypertrophy and Increased Left Atrial Size: The Korean Genome and Epidemiology Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-07-18 Seong Hwan Kim, Ju-Mi Lee, Seung Ku Lee, Chol Shin, Jae-Hyeong Park
Background. Elevated single blood pressure (BP) measurement can be associated with the development of hypertension-mediated target organ damage including left ventricular hypertrophy (LVH) and left atrial (LA) enlargement (LAE). However, long-term patterns of BP and their effects on LVH and LAE are poorly understood. We evaluated the association between the BP trajectories and the presence of LVH and
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Adherence to Self-Care among Patients with Hypertension in Ethiopia: A Systematic Review and Meta-Analysis Int. J. Hypertens. (IF 1.9) Pub Date : 2022-07-16 Afework Edmealem, Sewunet Ademe, Sisay Gedamu
Background. Self-care adherence for hypertensive patients is a cornerstone for the control of it and prevention of its complications. However, there are inconsistent findings for self-care adherence of hypertensive patients in Ethiopia. Thus, this systematic review and meta-analysis was done to determine the pooled estimate self-care adherence. Methods. This systematic review and meta-analysis was
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Emergent Anthropometric Indices in Differential Prediction of Prehypertension and Hypertension in Mexican Population: Results according to Age and Sex Int. J. Hypertens. (IF 1.9) Pub Date : 2022-07-07 Oscar Zaragoza-García, Ilse Adriana Gutiérrez-Pérez, Pedro Delgado-Floody, Isela Parra-Rojas, Daniel Jerez-Mayorga, Christian Campos-Jara, Iris Paola Guzmán-Guzmán
Background. Hypertension (HTN) is recognized as a significant public health problem in the world. The objective of this study is to evaluate emergent anthropometric indices as predictors of preHTN and HTN according to age and sex in a sample of Mexican adults. Methods. A cross-sectional study was conducted in 1,150 participants aged 18–80 years old. Anthropometric data and blood pressure measurements
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Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes Int. J. Hypertens. (IF 1.9) Pub Date : 2022-07-07 Kentaro Watanabe, Noe Takakubo, Taro Saigusa, Akiko Nagasawa, Midori Yamana, Midori Ojima, Wataru Kameda, Shinji Susa, Kenichi Ishizawa, Ishihara Hisamitsu
This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid
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Gender Differences in Cardiovascular Risk Factors, Clinical Presentation, and Outcome of Patients Admitted with a Hypertensive Crisis at the Buea Regional Hospital, Cameroon Int. J. Hypertens. (IF 1.9) Pub Date : 2022-06-28 Clovis Nkoke, Ahmadou Musa Jingi, Jean Jacques Noubiap, Denis Teuwafeu, Cyrille Nkouonlack, Ronald Gobina, Siddikatou Djibrilla, Ali Abas, Anastase Dzudie
Background. Several recent studies have shown differences in the risk profile and outcome of cardiovascular diseases between men and women, with a dearth of data from African populations. This study aimed to examine gender differences in a group of patients from Cameroon hospitalized with a hypertensive crisis. Methods. We conducted a cross-sectional study from June 2018 until June 2019. The criteria
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Comparison of Blood Pressure Variability between 24 h Ambulatory Monitoring and Office Blood Pressure in Diabetics and Nondiabetic Patients: A Cross-Sectional Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-06-21 Ana Lídia Rouxinol-Dias, Marta Lisandra Gonçalves, Diogo Ramalho, Jose Silva, Loide Barbosa, Jorge Polónia
Background. Evidence regarding blood pressure (BP) variability (BPV) and its independent association with adverse outcomes has grown. Diabetic patients might have increased BPV, but there is still an evidence gap regarding relation between BPV and type 2 diabetes beyond mean values of BP. Objective. To examine the relationship between 24 h ambulatory BP monitoring (ABPM, short-term variability) and
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High Sucrose Ingestion during a Critical Period of Vessel Development Promotes the Synthetic Phenotype of Vascular Smooth Muscle Cells and Modifies Vascular Contractility Leading to Hypertension in Adult Rats Int. J. Hypertens. (IF 1.9) Pub Date : 2022-06-21 Vicente Castrejón-Téllez, María Esther Rubio-Ruiz, Agustina Cano-Martínez, Israel Pérez-Torres, Leonardo Del Valle-Mondragón, Elizabeth Carreón-Torres, Verónica Guarner-Lans
Cardiometabolic diseases, including hypertension, may result from exposure to high sugar diets during critical periods of development. Here, we studied the effect of sucrose ingestion during a critical period (CP) between postnatal days 12 and 28 of the rat on blood pressure, aortic histology, vascular smooth muscle phenotype, expression of metalloproteinases 2 and 9, and vascular contractility in
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Prevalence and Associated Factors of Hypertension among Women in Southern Ghana: Evidence from 2014 GDHS Int. J. Hypertens. (IF 1.9) Pub Date : 2022-06-20 Cyprian Issahaku Dorgbetor, Kwamena Sekyi Dickson, Edward Kwabena Ameyaw, Kenneth Setorwu Adde
Background. Hypertension, coupled with prehypertension and other hazards such as high blood pressure, is responsible for 8·5 million deaths from stroke, ischaemic heart disease, other vascular diseases, and renal disease worldwide. Hypertension is the fifth commonest cause of outpatient morbidity in Ghana. Some evidence have illustrated geographical variation in hypertension and it seems to have a
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Combination of Oxalobacter Formigenes and Veillonella Parvula in Gastrointestinal Microbiota Related to Bile-Acid Metabolism as a Biomarker for Hypertensive Nephropathy Int. J. Hypertens. (IF 1.9) Pub Date : 2022-05-17 Xin Li, Li Wang, Shaojun Ma, Shaohui Lin, Chunyan Wang, Haiya Wang
The human microbiome is a mixed group of microorganisms, which individually consists of 10–100 trillion symbiotic microbial cells. The relationship between gastrointestinal microbiota and blood pressure has been verified and the intestinal microbiota of chronic kidney disease (CKD) patients in the distribution of bacterial species is different from the flora of people with no CKD. The purpose of this
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The Value of Four Anthropometric Indicators for Identifying Left Ventricular Hypertrophy in Chinese Hypertensive Patients Int. J. Hypertens. (IF 1.9) Pub Date : 2022-05-17 Bokai Cheng, Nan Lu, Ge Song, Jiaojiao Qiu, Jing Dong, Shuang Cai, Yongkang Su, Jin Sun, Anhang Zhang, Qiligeer Bao, Man Li, Shouyuan Ma, Yan Zhang, Ping Zhu, Shuxia Wang
Left ventricular hypertrophy (LVH) has been classified separately as an independent risk factor for hypertension. However, comparisons between different body size indices and left ventricular hypertrophy (LVH) in hypertensive populations have not been reported yet. In this study, we enrolled 4,639 hypertensive patients from rural China. Anthropometric indices and cardiovascular disease risk factor
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Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial Int. J. Hypertens. (IF 1.9) Pub Date : 2022-04-30 Hong Ding, Shu Liu, Ke-Xin Zhao, Jie Pu, Ya-Fei Xie, Xiao-Wei Zhang
Hypertension induces both structural and functional changes in blood vessels, thereby increasing endothelial dysfunction, which in turn, contributes to an increase in blood pressure. A popular and widely used noninvasive tool, flow-mediated dilation (FMD), is used to examine peripheral artery endothelium-dependent dilation. This study aimed to compare the efficacies of different classes of antihypertensive
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Self-Monitoring Home Blood Pressure in Community-Dwelling Older People: Age Differences in White-Coat and Masked Phenomena and Related Factors—The SONIC Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-04-30 Jinmei Tuo, Kayo Godai, Mai Kabayama, Yuya Akagi, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Saori Yasumoto, Yukie Masui, Yasumichi Arai, Kazunori Ikebe, Yasuyuki Gondo, Tatsuro Ishizaki, Hiromi Rakugi, Kei Kamide
Some studies reported that home blood pressure (HBP) monitoring was conducted by community-dwelling older people themselves, but there have been few studies on HBP including very old populations aged over 90 years old. Thus, the aim of the present study was to clarify the current situation of white-coat and masked phenomena defined by on-site and home BP measurements in community-dwelling old and oldest-old
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Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital Int. J. Hypertens. (IF 1.9) Pub Date : 2022-04-18 Elif Ağaçayak, Rezan Bugday, Nurullah Peker, Ugur Deger, Gönül Ölmez Kavak, Mehmet Siddik Evsen, Talip Gul
Objective. The study aimed to compare patients with HELLP syndrome who require intensive care and who do not require intensive care and evaluate the factors affecting the length of stay in the intensive care unit. Methods. Patients were divided into two groups as follows: requiring intensive care (group 1) and not requiring intensive care (group 2). The data of both groups were compared in terms of
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Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study Int. J. Hypertens. (IF 1.9) Pub Date : 2022-04-14 Parvin Khalili, Saeedeh Abdollahpoor, Fatemeh Ayoobi, Alireza Vakilian, Hamid Hakimi, Zohreh Rajabi, Zahra Jamali
Background. Hypertension as a major risk factor for cardiovascular diseases is among the leading causes of death worldwide. The relationship between elevated serum levels of liver enzymes and hypertension has been reported in limited studies, and to the best of our knowledge, there are no previous reports in the literature on this issue in the southeast of Iran. Our investigation aimed at evaluating
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Association of MTHFR Polymorphisms with H-Type Hypertension: A Systemic Review and Network Meta-Analysis of Diagnostic Test Accuracy Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-22 Yixuan Kong, Jinghui Zheng, Lijuan Li, Liying Lu, Jie Wang
Purpose. An association between MTHFR polymorphisms and H-type hypertension (H-HTN) has been investigated by epidemiological studies, but results have been inconsistent. Thus, a systematic assessment of the association was performed based on a literature review and pooled analysis, to provide stronger evidence on the effects of single nucleotide polymorphisms on H-HTN risk. Methods. Three investigators
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Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-19 Yi Liu, Xiaomu Kong, Yongwei Jiang, Meimei Zhao, Peng Gao, Xiao Cong, Yongtong Cao, Liang Ma
Background. The differences in the antihypertensive treatment with angiotensin type II receptor blockers (ARBs) may be attributed to polymorphisms in genes involving drug-targeted receptor and drug metabolism. The present study aimed to investigate whether the antihypertensive effect of the ARB drug valsartan was associated with angiotensin II type 1 receptor (AGTR1) gene polymorphism (A1166 C) and
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The Association of Serum Anti-Lysosomal-Associated Membrane Protein-2 Antibody with Vasculitis Combined with Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-18 Bin Zhu, Xintian Cai, Qing Zhu, Ting Wu, Shasha Liu, Shanshan Liu, Jing Hong, Nanfang Li
The aim of this study was to explore the association of serum anti-lysosomal-associated membrane protein-2 (anti-LAMP-2) antibody with vasculitis combined with hypertension (VAS-HTN). A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH
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Association between Quantitative Classification of Renal Surface Nodularity and Early Renal Injury in Patients with Arterial Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-04 Jun Zhou, Jiule Ding, Jie Chen, Qiong Wu, Dehui Xiang, Wei Xing
Background. This study sought to explore the association between quantitative classification of renal surface nodularity (qRSN) based on computed tomography (CT) imaging and early renal injury (ERI) in patients with arterial hypertension. Methods. A total of 143 patients with a history of hypertension were retrospectively enrolled; clinical information (age, sex, hypertension grade, and hypertension
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Skipping Breakfast Is Associated with Hypertension in Adults: A Meta-Analysis Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-03 Zishuo Li, Hongli Li, Qin Xu, Yanli Long
Previous studies evaluating the association between skipping breakfast and hypertension in adult population showed inconsistent results. We performed a meta-analysis to systematically evaluate the association. Observational studies which evaluated the relationship between skipping breakfast and hypertension in adult population with multivariate analyses were identified by systematic search of PubMed
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Plasma and Urinary Levels of Nerve Growth Factor Are Elevated in Primary Hypertension Int. J. Hypertens. (IF 1.9) Pub Date : 2022-03-01 Fumihiro Tomoda, Atsumi Nitta, Hiroko Sugimori, Tsutomu Koike, Koichiro Kinugawa
Nerve growth factor (NGF) is the main neurotrophic factor that can control sympathetic nerve innervation and sympathetic neural activity in cardiovascular organs. Although NGF overproduction and its influences on the sympathetic nervous system have been shown in hypertensive animals, NGF status and its association with sympathetic nerve activity have not yet been explored in human hypertension. In
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Prevalence of Cardiovascular Disease Risk Factors in the Women Population Covered by Health Centers in Ardabil Int. J. Hypertens. (IF 1.9) Pub Date : 2022-02-27 Leli Avesta, Sina Rasoolzadeh, Mahdi Naeim, Aziz Kamran
Objective. This study aimed to determine the prevalence of cardiovascular risk factors in the population of women aged 30 to 60 years covered by health centers in Ardabil. Methods. This retrospective descriptive-analytical study was conducted on 1006 women aged 30 to 60 years who were covered by Ardabil comprehensive urban health service centers, and they were selected by using the multistage random
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A Retrospective, Observational, EMR-Based Real-World Evidence Study to Assess the Incidence of Pedal Edema in Essential Hypertensive Patients on Amlodipine or Cilnidipine Int. J. Hypertens. (IF 1.9) Pub Date : 2022-02-23 Jamshed Dalal, J. P. Sawhney, P. B. Jayagopal, P. K. Hazra, Mohammed Yunus Khan, Kumar Gaurav, Colette Pinto, Amey Mane, Sachin Rao, Madhur Jain
Introduction. Calcium channel blockers have pedal edema as one of the confining factors of treatment. A real-world study may help evident reality of the situation in regular Indian clinical practice. The aim of the study is to assess effectiveness and incidence of pedal edema in essential hypertensive patients treated with amlodipine or cilnidipine monotherapy. Methods. Retrospective EMR data of adult
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Association between Particulate Matter Pollution Concentration and Hospital Admissions for Hypertension in Ganzhou, China Int. J. Hypertens. (IF 1.9) Pub Date : 2022-02-17 Chenwei Li, Xinye Zhou, Kun Huang, Xiaokang Zhang, Yanfang Gao
Fine particulate matter (PM2.5) and respirable particulate matter (PM10) are two major air pollutants with toxic effects on the cardiovascular system. Hypertension, as a chronic noncommunicable cardiovascular disease, is also a risk factor for several diseases. We applied generalized linear models with a quasi-Poisson link to assess the effect of air pollution exposure on the number of daily admissions