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Correction: Changes in heart failure management and long-term mortality over 10 years: observational study Open Heart Pub Date : 2024-03-01 British Cardiovascular Society
Bottle A, Newson R, Faitna P, et al . Changes in heart failure management and long-term mortality over 10 years: observational study. Open Heart 2022;9:e001888. doi: 10.1136/openhrt-2021-001888 This …
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Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study Open Heart Pub Date : 2024-03-01 Astrid Fritz Hansson, Angelo Modica, Henrik Renlund, Christina Christersson, Claes Held, Gorav Batra
Background Amiodarone is an established treatment for atrial fibrillation (AF) but might interfere with the metabolism of apixaban or warfarin. Therefore, the aim was to investigate the occurrence of major bleeding among patients with AF treated with amiodarone in combination with apixaban or warfarin. Methods Retrospective observational study using Swedish health registers. All patients with AF in
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OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring Open Heart Pub Date : 2024-03-01 Linsay McCallum, Stefanie Lip, Maggie Rostron, Rebecca Hanna, Nukman Bin Pg Md Salimin, Sarah Nichol, Sandosh Padmanabhan
Introduction Hypertension is the leading modifiable risk factor for cardiovascular disease and is implicated in half of all strokes and myocardial infarctions. One-third of the adults in Scotland have hypertension yet only a quarter of them have their blood pressure (BP) controlled to target (<140/90 mm Hg). Empowering patients to have a better understanding of their condition and becoming actively
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Diagnostic accuracy of baseline troponin and troponin change for the diagnosis of myocardial infarction complicated with heart failure Open Heart Pub Date : 2024-03-01 Matteo Serenelli, Beatrice Dal Passo, Simone Biscaglia, Paolo Tolomeo, Luca Di Ienno, Anna Cantone, Federico Sanguettoli, Roberta Campana, Federico Marchini, Matteo Arzenton, Daniele Maio, Valentino Santori, Gianluca Campo
Background The diagnosis of myocardial infarction (MI) in the presence of heart failure (HF) presents a clinical problem. While diagnostic algorithms using high-sensitivity cardiac troponin have been established for suspected MI, their accuracy in patients with HF remains uncertain. This study aims to assess the diagnostic accuracy of high-sensitivity troponin I (TnI) levels in identifying acute MI
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Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis Open Heart Pub Date : 2024-03-01 Valentino Collini, Alessandro Andreis, Marzia De Biasio, Maria De Martino, Miriam Isola, Nicole Croatto, Veronica Lepre, Luca Cantarini, Marco Merlo, Gianfranco Sinagra, Antonio Abbate, George Lazaros, Antonio Brucato, Allan L Klein, Massimo Imazio
Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional
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Incidence, presentation and outcome of acute aortic dissection: results from a population-based study Open Heart Pub Date : 2024-03-01 Christian Smedberg, Rebecka Hultgren, Christian Olsson, Johnny Steuer
Objectives To describe the incidence of acute aortic dissection in a clearly defined population, to assess onset symptoms and admission biochemical marker levels and to analyse variables potentially associated to mortality. Methods Medical records and CT angiograms of all patients hospitalised for acute aortic dissection in the Stockholm County during the 5-year period 2012–2016 were reviewed. The
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Time to childbirth and assisted reproductive treatment in women with congenital heart disease Open Heart Pub Date : 2024-03-01 Sara Jonsson, Inger Sundström-Poromaa, Bengt Johansson, Jenny Alenius Dahlqvist, Christina Christersson, Mikael Dellborg, Alexandra Trzebiatowska-Krzynska, Peder Sörensson, Ulf Thilén, Anna-Karin Wikström, Annika Bay
Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched
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Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19 Open Heart Pub Date : 2024-03-01 Shruti Hegde, Mina Shnoda, Yasser Alkhadra, Adhiraj Bhattacharya, Maria Nikolaeva, Michael Maysky
Importance Although cardiac injury is a known complication of COVID-19 infection, there is no established tool to predict cardiac involvement and in-hospital mortality in this patient population. Objective To assess if left ventricular global longitudinal strain (LV-GLS) can detect cardiac involvement and be used as a risk-stratifying parameter for hospitalised patients with COVID-19. Main outcomes
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Validation of 2D flow MRI for helical and vortical flows Open Heart Pub Date : 2024-03-01 Zia Mehmood, Hosamadin Assadi, Ciaran Grafton-Clarke, Rui Li, Gareth Matthews, Samer Alabed, Rebekah Girling, Victoria Underwood, Bahman Kasmai, Xiaodan Zhao, Fabrizio Ricci, Liang Zhong, Nay Aung, Steffen Erhard Petersen, Andrew J Swift, Vassilios S Vassiliou, João Cavalcante, Rob J van der Geest, Pankaj Garg
Purpose The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root. Methods This proof-of-concept study used four-dimensional (4D) flow cardiovascular MR (4D flow CMR) data of five healthy controls, five patients with heart failure with preserved ejection fraction and five patients with aortic
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Mixed plaque on coronary CT angiography predicts atherosclerotic events in asymptomatic intermediate-risk individuals Open Heart Pub Date : 2024-03-01 Josephine Warren, Andris Ellims, Jason Bloom, Nigel Sutherland, Philip Lew, Helen Kavnoudias, Sarang Paleri, Dion Stub, Andrew Taylor
Objective Coronary CT angiography (CCTA) permits both qualitative and quantitative analysis of atherosclerotic plaque and may be a suitable risk modifier in assessing patients at intermediate risk of atherosclerotic cardiovascular disease. We sought to determine the association of plaque components with long-term major adverse cardiovascular events (MACEs) in asymptomatic intermediate-risk patients
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Expanded application of wearable cardioverter defibrillators beyond current guidelines: proposal for a European register explained through single clinical scenarios Open Heart Pub Date : 2024-03-01 Veronica Buia, Francesco Ciotola, Dirk Bastian, Dorina Stangl, Janusch Walascheck, Harald Rittger, Laura Vitali-Serdoz
The wearable cardioverter defibrillator (WCD) is becoming a more and more widely used instrument for the prevention of sudden cardiac death of patients either with a secondary prevention implantable cardioverter defibrillator indication or with a transient high risk of sudden cardiac death. Although clinical practice has demonstrated a benefit of protecting patients for a period as long as 3–6 months
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Efficacy and safety of novel left ventricular pacing leads: 1-year analysis of the NAVIGATOR trial Open Heart Pub Date : 2024-02-01 Juan Gabriel Martinez, Joao De Sousa, Antoine Dompnier, Mario Martins -Oliveira, Carsten W Israel, Elvis Teijeira, José Manuel Rubin, Frederic Sebag, Maria Martino, Yann Michel, Pedro Marques
Objectives Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D (‘S shaped’) and NAVIGO 4LV ARC (‘U shaped’). Methods Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, [NCT03279484][1]). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10
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Midterm outcomes of transcatheter aortic valve replacement in patients with active cancer Open Heart Pub Date : 2024-02-01 Masahiko Noguchi, Minoru Tabata, Joji Ito, Nahoko Kato, Kotaro Obunai, Hiroyuki Watanabe, Fumiaki Yashima, Yusuke Watanabe, Toru Naganuma, Masahiro Yamawaki, Futoshi Yamanaka, Shinichi Shirai, Hiroshi Ueno, Norio Tada, Masanori Yamamoto, Kentaro Hayashida
Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. Methods Data from the OCEAN-TAVI, a prospective Japanese registry of TAVR procedures, was analysed to compare prognoses
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Skeletal muscle mitochondrial capacity in patients with statin-associated muscle symptoms (SAMS) Open Heart Pub Date : 2024-02-01 Laura A. Mangone, Beth A. Taylor, Robert Schmelzer, Sung Gi Noh, Michael C White, Oh Sung Kwon, Paul D Thompson
Objective The objective of this article is to evaluate near-infrared spectroscopy (NIRS), a non-invasive technique to assess tissue oxygenation and mitochondrial function, as a diagnostic tool for statin-associated muscle symptoms (SAMS). Methods We verified SAMS in 39 statin-treated patients (23 women) using a double-blind, placebo-controlled, cross-over protocol. Subjects with suspected SAMS were
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Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study Open Heart Pub Date : 2024-02-01 Yaniv Chocron, Markos Rousakis, Peter Vollenweider, Julien Vaucher, Pedro-Manuel Marques-Vidal
Background High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting. Methods Population-based prospective study conducted in Lausanne, Switzerland, with a follow-up between 2003 and 2021. Participants were categorised as normal BP, untreated
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Personalised preinterventional risk stratification of mortality, length of stay and hospitalisation costs in transcatheter aortic valve implantation using a machine learning algorithm: a pilot trial Open Heart Pub Date : 2024-02-01 Maria Zisiopoulou, Alexander Berkowitsch, Leonard Redlich, Thomas Walther, Stephan Fichtlscherer, David M Leistner
Introduction Risk stratification based on Euroscore II (ESII) is used in some centres to assist decisions to perform transcatheter aortic valve implant (TAVI) procedures. ESII is a generic, non-TAVI-specific metric, and its performance fades for mortality at follow-up longer than 30 days. We investigated if a TAVI-specific predictive model could achieve improved predictive preinterventional accuracy
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Effect of psychosocial aspects on medication adherence in patients with heart failure amid socioeconomic challenges Open Heart Pub Date : 2024-02-01 Hiba Deek, Angela Massouh
Objective To evaluate stress, depression and quality of life among community-dwelling patients with heart failure (HF) and evaluate their effect on perceived medication adherence in a socioeconomically challenged setting. Design A cross-sectional design with self-administered questionnaire with data collected between October 2021 and September 2022. Methods Patients with confirmed diagnosis of HF were
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Prognostic value of right ventricular free-wall longitudinal strain in patients with pulmonary hypertension: systematic review and meta-analyses Open Heart Pub Date : 2024-02-01 Yosuke Nabeshima, Tetsuji Kitano, Koichi Node, Masaaki Takeuchi
Background Right ventricular (RV) dysfunction is associated with adverse outcomes in patients with pulmonary hypertension (PH). This systematic review and meta-analysis evaluated the prognostic value of RV free-wall longitudinal strain (RVfwLS), compared with other RV parameters in PH. Methods We searched for articles presenting the HR of two-dimensional RVfwLS in PH. HRs were standardised using the
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Living with myocardial ischaemia and no obstructive coronary arteries: a qualitative study Open Heart Pub Date : 2024-02-01 Helen Humphreys, Danielle Paddock, Sarah Brown, Colin Berry, Aynsley Cowie, Susan Dawkes, Simon Nichols
Objective To explore the lived experience of people with myocardial ischaemia with no obstructive arteries. Design Qualitative study using semistructured interviews. Setting Telephone interviews with 17 participants living in the UK. Participants 17 people (2 males, 15 females; aged 31–69 years) with a presumed or confirmed diagnosis of myocardial ischaemia with no obstructive arteries, recruited via
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Correction: Contemporary use and outcome of Cabrol shunt in type A aortic dissection surgery: insight from China 5A study Open Heart Pub Date : 2024-02-01 British Cardiovascular Society
Liu H, Sun B, Qian S, et al . Contemporary use and …
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Comparative evaluation of microprobe versus conventional transoesophageal echocardiography for PFO closure guidance Open Heart Pub Date : 2024-01-01 Jemina Lanki, Suvi Tuohinen, Piia Simonen, Mikko Jalanko, Juha Sinisalo
Background Patent foramen ovale (PFO) closure is traditionally guided by transoesophageal echocardiography (TEE) under general anaesthesia, which prolongs procedure duration and increases costs and risks. A transnasal echocardiography with a microTEE-probe (microTNE) is tolerated under conscious sedation and offers an effective alternative to TEE. The aim of this study was to compare the feasibility
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Patients on vitamin K treatment: is switching to direct-acting oral anticoagulation cost-effective? A target trial on a prospective cohort Open Heart Pub Date : 2024-01-01 Helena Aebersold, Fabienne Foster-Witassek, Stefanie Aeschbacher, Juerg H Beer, Eva Blozik, Manuel Blum, Leo Bonati, Giulio Conte, Michael Coslovsky, Maria Luisa De Perna, Marcello Di Valentino, Stefan Felder, Carola A Huber, Giorgio Moschovitis, Andreas Mueller, Rebecca E Paladini, Tobias Reichlin, Nicolas Rodondi, Annina Stauber, Christian Sticherling, Thomas D Szucs, David Conen, Michael Kuhne,
Aims Direct-acting oral anticoagulants (DOACs) have, to a substantial degree, replaced vitamin K antagonists (VKA) as treatments for stroke prevention in atrial fibrillation (AF) patients. However, evidence on the real-world causal effects of switching patients from VKA to DOAC is lacking. We aimed to assess the empirical incremental cost-effectiveness of switching patients to DOAC compared with maintaining
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Initiation patterns of anticoagulants for atrial fibrillation among older UK adults with and without chronic kidney disease, 2010–2020 Open Heart Pub Date : 2024-01-01 Julia Liaw, Deborah Liaw, Chintan Dave
Background There is a paucity of data on the initiation patterns of anticoagulants among older atrial fibrillation patients with and without chronic kidney disease (CKD). Setting and methods We used the UK Clinical Practice Research Datalink (2010–2020) to conduct a retrospective cohort study to evaluate anticoagulant initiation patterns for older adults (≥65 years) with CKD (N=18 421) and without
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Effect of ischaemic postconditioning on markers of myocardial injury in ST-elevation myocardial infarction: a meta-analysis Open Heart Pub Date : 2024-01-01 Idan Bergman, Shaul Gelikas, Yehuda Wexler, Omri Braver, Dennis Boyle, Udi Nussinovitch
Objectives This study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers. Methods Eligible studies were identified using several article databases. Randomised controlled trials published between 1 January 2000 and 1 December 2021 comparing IPoC to standard
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Outpatient care of adults with congenital heart disease in the UK: a qualitative appraisal of the clinician perspective Open Heart Pub Date : 2024-01-01 Isobel Chaudhry, Anisa Ghassani, Jo Wray, Bill Chaudhry, Louise Coats
Objective This study aimed to explore clinicians’ perspectives of ambulatory care in adult congenital heart disease (ACHD). Methods Semistructured interviews were carried out remotely (Zoom) with a range of physicians providing ambulatory care to patients with ACHD across the UK. The chronic care model, thrive and candidacy frameworks were used to design prompt guides and subsequently develop themes
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Implementing a comprehensive STEMI protocol to improve care metrics and outcomes in patients with in-hospital STEMI: an observational cohort study Open Heart Pub Date : 2024-01-01 Christopher N Kanaan, Nicholas Kassis, Raunak M Nair, Anirudh Kumar, Chetan P Huded, Kathleen Kravitz, Grant W Reed, Amar Krishnaswamy, A Michael Lincoff, Jaikirshan Khatri, Rishi Puri, Khaled Ziada, Ravi Nair, Samir Kapadia, Umesh Khot
Background Patients who experience in-hospital ST-segment elevation myocardial infarction (iSTEMI) represent a uniquely high-risk cohort owing to delays in diagnosis, prolonged time to reperfusion and increased mortality. Quality initiatives aimed at improving the care of this vulnerable, yet understudied population are needed. Methods This study included consecutive patients with iSTEMI treated with
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Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation Open Heart Pub Date : 2024-01-01 Ebba-Louise Skogseid, Gorav Batra, Johan Westerbergh, Claes Held, Christina Christersson
Aim To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment. Methods All patients in Sweden undergoing valvular intervention with AF were included. Associations between OAC exposure and cardiovascular (CV) events (composite
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Cost-effectiveness of stepwise provisional versus systematic dual stenting strategies in patients with distal bifurcation left main stem lesions: economic analysis of the EBC MAIN trial Open Heart Pub Date : 2024-01-01 Alicia Le Bras, David Hildick-Smith, Arnaud Nze Ossima, Olivier Supplisson, Mohaned Egred, Philippe Brunel, Adrian P Banning, Marie-Claude Morice, Isabelle Durand-Zaleski
Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic
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Multiprofessional heart failure self-development framework Open Heart Pub Date : 2024-01-01 Paul Forsyth, Susan Young, Kirsty Hughes, Ruby James, Cheryl Oxley, Ruth Kelly, Rebecca Jones, Sarah Briggs, Lynn Mackay-Thomas, Yvonne Millerick, Maggie Simpson, Clare J Taylor, Simon Beggs, Susan Piper, Simon Duckett
Objective Heart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old. Many such patients transcend the standard interventions that are well characterised and evidenced in guidelines, into holistic aspects surrounding frailty, rehabilitation and social care. Previous published competency frameworks in
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Reflections on my journey as editor-in-chief of Open Heart Open Heart Pub Date : 2024-01-01 Pascal Meier
As I approach the end of my tenure as founding editor-in-chief of Open Heart , I am filled with a sense reflection on this very exciting journey. When we launched Open Heart in January 2014, our mission was to advance scientific publishing in cardiovascular sciences by embracing open science, making research results available to everyone. This was a response to the limitations of traditional publishing
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Association of HFA-PEFF score with clinical outcomes after catheter ablation for atrial fibrillation Open Heart Pub Date : 2024-01-01 Taiji Okada, Takeshi Kitai, Atsushi Kobori, Madoka Sano, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Tomohiko Taniguchi, Kitae Kim, Natsuhiko Ehara, Makoto Kinoshita, Yutaka Furukawa
Background The Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing and final aetiology (HFA-PEFF) score has been developed for diagnosing heart failure with preserved ejection fraction (HFpEF), which is frequently associated with atrial fibrillation (AF). We aimed to investigate whether preprocedural HFA-PEFF score could be used to predict clinical
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Prognostic value of right ventricular dyssynchrony in adults with repaired tetralogy of Fallot Open Heart Pub Date : 2024-01-01 Andrea Papa, Clement Nussbaumer, Eleni Goulouti, Fabienne Schwitz, Kerstin Wustmann, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann
Objective Residual sequelae after surgical repair of tetralogy of Fallot (rTOF) affect clinical outcome. We investigated the prognostic impact of right ventricular (RV) dyssynchrony in adults with rTOF years after the surgical repair. Methods Patients from the Swiss Adult Congenital HEart disease Registry were included. NT-proBNP levels, echocardiography, exercise testing and MRI data were collected
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Use of sacubitril/valsartan early after CABG Open Heart Pub Date : 2024-01-01 Madina Nurzhanova, Aisulu Musagaliyeva, Raushan Zhakypova, Daniya Senkibayeva, Amina Rakisheva
Background Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary artery bypass graft (CABG) may be superior to medical therapy in improving survival. However, CABG may be associated with substantial risk in HF subjects
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Economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from an English National Health Service perspective Open Heart Pub Date : 2024-01-01 John Paisey, Joe Moss, Jason Andrade, Malte Kuniss, Oussama Wazni, Gian Battista Chierchia, Stuart Mealing, Eleni Ismyrloglou, Alicia Sale, Maxim Souter, Rachelle Kaplon, Tom Bromilow, Emily Lane, Damian Lewis, Derick Todd
Introduction Three recent randomised controlled trials have demonstrated that pulmonary vein isolation as an initial rhythm control strategy with cryoablation reduces atrial arrhythmia recurrence in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drug (AAD) therapy. The aim of this study was to evaluate the cost-effectiveness of first-line cryoablation compared
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Accelerating progress in cardiology: embracing open science Open Heart Pub Date : 2024-01-01 Pascal Meier
Open science is not only compelling but also essential for the advancement of cardiology. Open science encompasses open-access publishing, data sharing and open source. It embodies a set of practices aiming for greater transparency and collaboration in research (figure 1). It is pivotal for driving innovation, ensuring research integrity and democratising access to scientific knowledge. The societal
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Colchicine in acute myocardial infarction: cardiovascular events at 1-year follow up Open Heart Pub Date : 2024-01-01 Claire Bouleti, Simon Viscogliosi, Didier Bresson, Simon Leboube, Thomas Bochaton, Naoual El-Jonhy, Camille AMAZ, Fabrice Prunier, Gabriel Bidaux, Francois Roubille, Denis Angoulvant, Nathan Mewton
Objective In the COVERT-MI randomised placebo-controlled trial, oral administration of high-dose colchicine at the time of reperfusion and for 5 days in acute ST-elevated myocardial infarction did not reduce infarct size but was associated with a significant increase in left ventricular thrombus (LVT) in comparison to placebo. We aimed to assess the 1-year clinical outcomes of the study population
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Cardiology researchers’ practices and perceived barriers to open science: an international survey Open Heart Pub Date : 2024-01-01 Kelly D Cobey, Mohsen Alayche, Sara Saba, Nana Yaa Barnes, Sanam Ebrahimzadeh, Emilio Alarcón, Benjamin Hibbert, David Moher
Objective Open science is a movement and set of practices to conduct research more transparently. Implementing open science will significantly improve public access and supports equity. It also has the potential to foster innovation and reduce duplication through data and materials sharing. Here, we survey an international group of researchers publishing in cardiovascular journals regarding their perceptions
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Correction: Multimorbidity of cardiovascular disease subtypes in a prospective cohort of 1.2 million UK women Open Heart Pub Date : 2024-01-01 British Cardiovascular Society
Suh JW, Floud S, Reeves GK, et al . Multimorbidity of cardiovascular disease subtypes in a prospective cohort of 1.2 million …
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Fluoroquinolones do not provide added risk of out-of-hospital cardiac arrest: a nationwide study Open Heart Pub Date : 2024-01-01 Viktoría Ellenardóttir, Ruben Coronel, Fredrik Folke, Andrim Halili, Anojhaan Arulmurugananthavadivel, Saaima Parveen, Mikkel Porsborg Andersen, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Talip E Eroglu
Aim Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the inherent comorbidities or whether there is a direct pro-arrhythmic effect of FQs. Therefore, we studied the relation between FQs and OHCA in the general population
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Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome Open Heart Pub Date : 2024-01-01 Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita
Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated
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Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function Open Heart Pub Date : 2024-01-01 Nagendra Boopathy Senguttuvan, Nishok Victory Srinivasan, Manokar Panchanatham, Rizwan Suliankatchi Abdulkader, Asuwin Anandaram, Dinesh Reddy Polareddy, Sankaran Ramesh, Harsimran Singh, Hanumath Yallanki, Dhamodaran Kaliyamoorthi, Sundar Chidambaram, Vadivelu Ramalingam, Ravindran Rajendran, Thoddi Ramamurthy Muralidharan, Ravindar Rao, Ashok Seth, Bimmer Claessen, Parasuram Krishnamoorthy
Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines. We intended to study the effect of early AVR (eAVR) in this subset of asymptomatic patients
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Impact of serum haemoglobin-to-creatinine ratio after transcatheter aortic valve implantation Open Heart Pub Date : 2023-12-01 Akihiro Ikuta, Satoki Oka, Shunsuke Matsushita, Shingo Hirao, Kazushige Kadota, Tatsuhiko Komiya, Yasushi Fuku
Objective The association between a combined anaemia and renal failure index and 1-year prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. We aimed to investigate a simple risk score in patients undergoing TAVI. Methods A total of 469 consecutive patients undergoing TAVI between 2015 and 2021 were enrolled. After excluding patients undergoing dialysis, the
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Differences in treatment and clinical outcomes in patients aged ≥75 years compared with those aged ≤74 years following acute coronary syndromes: a prospective multicentre study Open Heart Pub Date : 2023-12-01 Michael Lawless, Abdulla Damluji, Valerie Josephine Dirjayanto, Gregory Mills, Graziella Pompei, Francesca Rubino, Vijay Kunadian
Objective This study describes the differences in treatment and clinical outcomes in patients aged ≥75 years compared with those aged ≤74 years presenting with acute coronary syndrome (ACS) and undergoing invasive management. Methods A large-scale cohort study of patients with ST-elevation/non-ST-elevation myocardial infarction (MI)/unstable angina underwent coronary angiography (January 2015–December
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Implementation of the European Society of Cardiology 0/3-hour accelerated diagnostic protocol, using high sensitive troponin T: a clinical practice evaluation of safety and effectiveness involving 3003 patients with suspected acute coronary syndrome Open Heart Pub Date : 2023-12-01 James Daniel Hatherley, Thomas Salmon, Paul O Collinson, Aleem Khand
Background There have been relatively few studies detailing the real-world effectiveness and safety of accelerated diagnostic protocols (ADP), using high sensitivity cardiac troponin (hs-cTn). Objective To analyse the safety and effectiveness of early emergency department (ED) discharge following implementation of the European Society of Cardiology (ESC) 0/3-hour ADP for suspected acute coronary syndromes
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Women have less progression of paroxysmal atrial fibrillation: data from the RACE V study Open Heart Pub Date : 2023-12-01 Bart A Mulder, Neda Khalilian Ekrami, Martijn E Van De Lande, Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J Crijns, Bastiaan Geelhoed, Yuri Blaauw, Martin EW Hemels, Robert G Tieleman, Coert OS Scheerder, Mirko De Melis, Ulrich Schotten, Dominik Linz, Isabelle C Van Gelder, Michiel Rienstra
Background Sex differences in atrial fibrillation (AF) are observed in terms of comorbidities, symptoms, therapies received, AF progression and cardiovascular complications. Methods We assessed the differences in prevalence and the determinants of AF progression, as well as the clinical characteristics and quality of life (QoL), between women and men with paroxysmal AF included in the RACE V (Reappraisal
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Cardiac MR modelling of systolic and diastolic blood pressure Open Heart Pub Date : 2023-12-01 Hosamadin Assadi, Gareth Matthews, Xiaodan Zhao, Rui Li, Samer Alabed, Ciaran Grafton-Clarke, Zia Mehmood, Bahman Kasmai, Vaishali Limbachia, Rebecca Gosling, Gurung-Koney Yashoda, Ian Halliday, Peter Swoboda, David Paul Ripley, Liang Zhong, Vassilios S Vassiliou, Andrew J Swift, Rob J van der Geest, Pankaj Garg
Aims Blood pressure (BP) is a crucial factor in cardiovascular health and can affect cardiac imaging assessments. However, standard outpatient cardiovascular MR (CMR) imaging procedures do not typically include BP measurements prior to image acquisition. This study proposes that brachial systolic BP (SBP) and diastolic BP (DBP) can be modelled using patient characteristics and CMR data. Methods In
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Heart failure: it’s time to finally change the F-word Open Heart Pub Date : 2023-12-01 Carolyn Thomas
One of the organisers of an upcoming medical conference on heart failure told me that the theme of this meeting ‘was intended to provide hope’. Noble intention, indeed. Yet that’s the problem with the name heart ‘failure’. By definition, it s tough to ‘provide hope’ while continuing to tell freshly diagnosed heart patients that their hearts are ‘failing’. I often hear from my readers who have sat through
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Factors influencing deviation from target temperature during targeted temperature management in postcardiac arrest patients Open Heart Pub Date : 2023-12-01 Kanae Ochiai, Yasuhiro Otomo
Background Targeted temperature management (TTM) is a recommended therapy for postcardiac arrest patients. Hyperthermia worsened the patient outcome, and overcooling increased the incidence of complications; therefore, a high-quality TTM is required. The target temperature tended to be modified worldwide after the TTM trial in 2013. Our institute modified the target temperature to 35°C in 2017. This
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Effect of aerobic exercise training on pulse wave velocity in adults with and without long-term conditions: a systematic review and meta-analysis Open Heart Pub Date : 2023-12-01 Majda Bakali, Thomas CJ Ward, Enya Daynes, Amy V Jones, Grace M Hawthorne, Lorna Latimer, Pip Divall, Matt Graham-Brown, Gerry P McCann, Thomas Yates, Michael C Steiner, Rachael Andrea Evans
Rationale There is conflicting evidence whether aerobic exercise training (AET) reduces pulse wave velocity (PWV) in adults with and without long-term conditions (LTCs). Objective To explore whether PWV improves with AET in adults with and without LTC, to quantify the magnitude of any effect and understand the influence of the exercise prescription. Data sources CENTRAL, MEDLINE and EMBASE were among
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Multimorbidity of cardiovascular disease subtypes in a prospective cohort of 1.2 million UK women Open Heart Pub Date : 2023-12-01 Jae Won Suh, Sarah Floud, Gillian K Reeves, Benjamin J Cairns, Frances Lucy Wright
Objective Cardiovascular multimorbidity (CVM) is the co-occurrence of multiple cardiovascular disease subtypes (CVDs) in one person. Because common patterns and incidence of CVM are not well-described, particularly in women, we conducted a descriptive study of CVM in the Million Women Study, a large population-based cohort of women. Methods UK women aged 50–64 years were followed up using hospital
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Adult congenital heart disease training in Europe: current status, disparities and potential solutions Open Heart Pub Date : 2023-12-01 Colin J McMahon, Inga Voges, Petra Jenkins, Margarita Brida, Annemien E van der Bosch, Mikael Dellborg, Ruth Heying, Jörg I Stein, Borislav Georgiev, Senka Mesihovic-Dinarevic, Katja Prokšelj, Gylfi Oskarsson, Alexandra Frogoudaki, Tevfik Karagöz, Antonis Jossif, Gabriela Doros, Dorte Nielsen, Mikko Jalanko, Inmaculada Sanchez Perez, Sílvia Alvares, Mette-Elise Estensen, Andreas Petropoulos, Raili
Objectives This study aimed to determine the status of training of adult congenital heart disease (ACHD) cardiologists in Europe. Methods A questionnaire was sent to ACHD cardiologists from 34 European countries. Results Representatives from 31 of 34 countries (91%) responded. ACHD cardiology was recognised by the respective ministry of Health in two countries (7%) as a subspecialty. Two countries
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Clinical risk associated with COVID-19 among 86000 patients with congenital heart disease Open Heart Pub Date : 2023-12-01 Simon G. Williams, Simon Frain, Hui Guo, Matthew J Carr, Darren M Ashcroft, Bernard D Keavney
Objective To determine the magnitude of any excess risk of mortality and hospitalisation due to COVID-19 infection in patients with congenital heart disease (CHD) in the UK healthcare system. Methods Matched case–control study within the Clinical Practice Research Datalink study of anonymised general practice records in the National Health Service in England. Patients with CHD were stratified for disease
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Country and health expenditure are major predictors of withholding anticoagulation in atrial fibrillation patients at high risk of stroke Open Heart Pub Date : 2023-12-01 Deborah M Siegal, Frederik H Verbrugge, Anne-Celine Martin, Saverio Virdone, John Camm, Karen Pieper, Bernard J Gersh, Shinya Goto, Alexander G G Turpie, Pantep Angchaisuksiri, Keith A A Fox
Background Guidelines for patients with atrial fibrillation (AF) at high thromboembolic risk recommend oral anticoagulants (OACs) for preventing stroke and systemic embolism (SE). The reasons for guideline non-adherence are still unclear. Aim The aim is to identify clinical, demographic and non-patient characteristics associated with withholding OAC in patients with AF at high stroke risk. Methods
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Integrating palliative care and heart failure: a systematic realist synthesis (PalliatHeartSynthesis) Open Heart Pub Date : 2023-12-01 Tracey McConnell, Carolyn Blair, John Burden, Claire Duddy, Loreena Hill, Clare Howie, Bob Jones, Bob Ruane, Geoff Wong, Joanne Reid
Objectives (1) Develop a programme theory of why, for whom and in what contexts integrated palliative care (PC) and heart failure (HF) services work/do not work; (2) use the programme theory to co-produce with stakeholders, intervention strategies to inform best practice and future research. Methods A systematic review of all published articles and grey literature using a realist logic of analysis
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Increased cardiovascular mortality in patients with mechanically expandable transcatheter aortic valve and without permanent pacemaker Open Heart Pub Date : 2023-12-01 Petr Hájek, Martin Horvath, Eva Hansvenclova, Monika Pecková, Radka Adlova
Introduction Use of the mechanically expandable transcatheter aortic valve (MEV) has been recently linked to increased risks of valve dysfunction and cardiovascular mortality. The risk of developing conduction disturbance with the MEV valve is well known, and the negative prognostic impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation is another consideration
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Contemporary use and outcome of Cabrol shunt in type A aortic dissection surgery: insight from China 5A study Open Heart Pub Date : 2023-12-01 Hong Liu, Bing-qi Sun, Si-chong Qian, Ming-yu Sun, Yong-feng Shao, Yi Ding, Hui Li, Hong-jia Zhang
Objective Cabrol shunt has been introduced for surgical repair of type A aortic dissection (TAAD) without robust evidence supporting its routine preventive use. Methods Adult patients with TAAD from China 5A study were included if surgically repaired between 2016 and 2022. Primary outcome was operative mortality according to Society of Thoracic Surgeons criterion. Overall, we compared clinical outcomes
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Resource utilisation and outcomes of people with heart failure in England: a descriptive analysis of linked primary and secondary care data – the PULSE study Open Heart Pub Date : 2023-12-01 Stephan Linden, Nicholas D Gollop, Ruth Farmer
Background Heart failure (HF) is associated with high levels of resource use and mortality, but prior UK studies have not compared outcomes by HF subtype (HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)) in large patient populations. This study investigated healthcare resource utilisation and mortality in patients with HF in England, overall and by HF subtype
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Difference in tissue temperature change between two cryoballoons Open Heart Pub Date : 2023-12-01 Takahiro Hayashi, Kohei Hamada, Kiyotaka Iwasaki, Jumpei Takada, Masato Murakami, Shigeru Saito
Background Cryoballoon ablation, especially Arctic Front Advance Pro (AFA-Pro) (Medtronic, Minneapolis, Minnesota, USA), has been widely recognised as a standard approach to atrial fibrillation (AF). Recently, Boston Scientific has released a novel cryoballoon system (POLARx). Despite comparable acute clinical outcomes of these two cryoballoons, the recent study reported a higher complication rate
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BNP level predicts bleeding event in patients with heart failure after percutaneous coronary intervention Open Heart Pub Date : 2023-12-01 Yasuhiro Otsuka, Masanobu Ishii, So Ikebe, Taishi Nakamura, Kenichi Tsujita, Koichi Kaikita, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Kazuomi Kario, Yasushi Imai, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoshihiro Miyamoto, Hisahiko Sato, Naoyuki Akashi, Hideo Fujita, Ryozo Nagai
Objective This study aimed to investigate the association between heart failure (HF) severity measured based on brain natriuretic peptide (BNP) levels and future bleeding events after percutaneous coronary intervention (PCI). Background The Academic Research Consortium for High Bleeding Risk presents a bleeding risk assessment for antithrombotic therapy in patients after PCI. HF is a risk factor for
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Cardiac dysfunction in survivors of sepsis: a scoping review Open Heart Pub Date : 2023-12-01 Kevin Garrity, Samantha Gaw, Alice Blewitt, Paul Canon, Philip McCall, Joanne McPeake
Background Sepsis is associated with an increased risk of adverse cardiovascular events in a magnitude comparable to other major cardiovascular risk factors. Sepsis is one of the most common reasons for intensive care admission and survivors often have significant functional limitations following discharge. However, it is not clear to what extent chronic cardiovascular dysfunction might mediate these