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Infratentorial Cerebral Cavernous Malformation May be a Risk Factor for Symptomatic Bleeding and Precocity of Symptoms: A Multicenter, Propensity Score Matched, Case-Control Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-03-14 Gustavo da Fontoura Galvão, Ricardo Castro Filho, Alexandre Alexandre Martins Cunha, Andre André Guimarães Soares, Marcos Antônio Dellaretti Filho, Jorge Marcondes de Souza
Background:: Cerebral Cavernous Malformation (CCM) is one of the most common types of vascular malformation of the central nervous system. Intracerebral hemorrhage, seizures, and lesional growth are the main clinical manifestations. Natural history studies have tried to identify many risk factors; however, the clinical course remains highly unpredictable. Objective:: Here, we have analyzed a multicenter
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Whole Transcriptome Sequencing of Peripheral Blood Identifies the Alzheimer's Disease-Related circRNA-miRNA-lncRNA Pathway Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-03-14 Yucheng Gu, Nihong Chen, Lin Zhu, Xiangliang Chen, Teng Jiang, Yingdong Zhang
Background:: Previous studies on transcriptional profiles suggested dysregulation of multiple RNA species in Alzheimer’s disease. However, despite recent investigations revealing various aspects of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) networks in Alzheimer's Disease (AD) pathogenesis, few genome-wide studies have explored circRNA-associated profiles in AD patients exhibiting
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Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-03-12 Jing-Xuan Li, Dai Shi, Si-Ying Ren, Guo-Feng Wu
Background: Drug-resistant epilepsy (DRE) is a refractory neurological disorder. There is ample evidence that suggest that γ-aminobutyric acid-a (GABAA) receptors could be one of the mechanisms responsible for the development of drug resistance in epilepsy. It is also known that the cAMP response element binding protein (CREB) plays a possible key role in the transcriptional regulation of GABAA. background:
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Lower Melatonin Indicates Poor Short-term Prognosis in Patients with Acute Ischemic Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-03-12 Qian Sun, Sheng-nan Chen, Si-yuan Yu, Fen Wang, Xiang Fu, Rui Chen, Jie Li
Aims: We evaluated endogenous melatonin levels in the acute phase of cerebral infarction and explored the impact of possible changes in melatonin levels on the prognosis of patients. Methods: This study recruited acute ischemic stroke (AIS) patients from the Department of the Second Affiliated Hospital of Soochow University between December 2019 and June 2021, along with healthy control subjects. Salivary
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Predictors of Emboli in Mechanical Thrombectomy for Anterior Circulation Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-03-05 Youngho Kwon, Ho Jun Yi, Dong-Seong Shin, Bum-Tae Kim
Objective: Emboli commonly occurs in mechanical thrombectomy (MT). The objective of this study was to analyze predicting factors of emboli after MT. background: N/A Methods: Patients who underwent MT with successful reperfusion for anterior circulation occlusion were enrolled. Emboli included distal emboli at digital subtraction angiography (DSA) and unexpected embolic infarct on diffusion-weighted
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The Mechanism of Astragaloside IV in NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome-mediated Pyroptosis after Intracerebral Hemorrhage Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-27 Honggang Wu, Shu Chen, Guoliang You, Bo Lei, Li Chen, Jiachuan Wu, Niandong Zheng, Chao You
Background:: Intracerebral hemorrhage (ICH) is one of the most common subtypes of stroke. Objectives:: This study aimed to investigate the mechanism of Astragaloside IV (AS-IV) on inflammatory injury after ICH. Methods:: The ICH model was established by the injection of collagenase and treated with ASIV (20 mg/kg or 40 mg/kg). The neurological function, water content of the bilateral cerebral hemisphere
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Electroacupuncture Alleviates Cerebral Ischemia-reperfusion Injury by Regulating the S1PR2/TLR4/NLRP3 Signaling Pathway via m6A Methylation of lncRNA H19 Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-27 Han-Rui Zhang, Gu-Quan Ma, He-Qun Lv, Yao-Ting Feng, Yong-Jun Peng
: Electroacupuncture (EA) treatment plays a protective role in cerebral ischemiareperfusion (CIR) injury. However, the underlying molecular mechanism is still not fully elucidated. Methods: All rats were randomly divided into five groups: the SHAM group, MCAO group, MCAO+EA (MEA) group, MCAO+METTL3 overexpression+EA (METTL3) group and MCAO+lncRNA H19 overexpression+EA (lncRNA H19) group. The middle
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Risk Factors for Cerebral Hyperperfusion Syndrome After Combined Revascularization in Adult Patients with Moyamoya Disease Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-07 Dongxiao Xu, Jiaojiao Guo, Bingjie Zheng, Qiaowei Wu, Ilgiz Gareev, Ozal Beylerli, Aferin Beilerli, Huaizhang Shi
Background: Cerebral hyperperfusion syndrome (CHS) is known as a complication after bypass surgery for Moyamoya disease (MMD). However, the incidence of CHS has not been accurately reported, and there is no consensus on the risk factors associated with it. Aim: The aim of this study was to determine the risk factors associated with postoperative CHS after surgical combined revascularization used to
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Association between Oxidative Balance Score and Severe Headache or Migraine among American Adults A Cross-Section Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-07 Dandan Geng, Huanxian Liu, Haoyuan Wang, Zhao Dong, Hebo Wang
Background: Migraine is implicated in oxidative stress. The oxidative balance score (OBS) assesses the combined impact of diet and lifestyle on oxidative and antioxidant balance in diseases. However, the association between OBS and migraine remains underexplored. Objective: We aimed to examine the relationship between OBS and severe headaches or migraines among American adults. Methods: This cross-sectional
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Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral Venous Reflux in Patients with Recent Small Subcortical Infarction Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-07 Zhengrong Wu, Ke Zhang, Ce Zong, Hongbing Liu, Yanhong Wang, Yuming Xu, Yuan Gao
Background: Research has linked enlarged perivascular spaces (EPVS) to cerebral venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear whether this association exists in recent small subcortical infarct (RSSI) patients. Objective: This study aimed to investigate the correlation between EPVS and CVR in patients with RSSI. Method: This study included 297 patients
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A Simple Score for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source in a Tunisian Cohort Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-07 Sana Ben Amor, Assil Achour, Aymen Elhraiech, Emna Jarrar, Hela Ghali, Ons Ben Ameur, Neserine Amara, Anis Hassine, Houyem Saied, Eleys Neffati, Didier Smadja
Background: The annualized recurrent stroke rate in patients with Embolic Stroke of Undetermined Source (ESUS) under antiplatelet therapy is around 4.5%. Only a fraction of these patients will develop atrial fibrillation (FA), to which a stroke can be attributed retrospectively. The challenge is to identify patients at risk of occult AF during follow-up. Objective: This work aims to determine clinical
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Risk Factors and Prognosis of Early Neurological Deterioration after Bridging Therapy Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-04 Yiju Xie, Shengyu Li, Liuyu Liu, Shiting Tang, Yayuan Liu, Shuangquan Tan, Zhijian Liang
Background: Early neurological deterioration (END) after bridging therapy (BT) of acute ischemic stroke (AIS) patients is associated with poor outcomes. Objective: We aimed to study the incidence, risk factors and prognosis of END after BT. Methods: From January to December 2021, the clinical data of AIS patients treated by BT (intravenous thrombolysis with alteplase prior to mechanical thrombectomy)
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TRUST Technique for Neurointervention: A Promising Alternative for Complex Cases Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-04 Xinzhao Jiang, Peng Wang, Fang Liu, Huadong Wu, Peng Jiang, Ruozhen Yuan, Sheng Zhang, Zongjie Shi
Background: Neurointervention via Transradial Access (TRA) is becoming increasingly popular as experience with this technique increases. However, approximately 8.6–10.3% of complex TRA cases are converted to femoral access due to a lack of support or radial artery spasm. This study aimed to assess the efficacy and safety of the TRUST (trans-radial coaxial catheter technique using a short sheath, Simmons
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Disulfidptosis and its Role in Peripheral Blood Immune Cells after a Stroke: A New Frontier in Stroke Pathogenesis Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-02-01 Shan-peng Liu, Cuiying Liu, Baohui Xu, Hongmei Zhou, Heng Zhao
Background: Stroke-Induced Immunodepression (SIID) is characterized by apoptosis in blood immune populations, such as T cells, B cells, NK cells, and monocytes, leading to the clinical presentation of lymphopenia. Disulfidptosis is a novel form of programmed cell death characterized by accumulating disulfide bonds in the cytoplasm, resulting in cellular dysfunction and eventual cell death. Objective:
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Evaluation of Quantitative and Selective Sensory Fiber Dysfunction in Patients with Cirrhosis Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-29 Nan-nan Zhang, Zhi-yong Wang, Jian-min Chen, Zhi-peng Yan, Guo-xin Ni, Jun Ni
Background: Chronic liver disease has been reported to be associated with peripheral neuropathy. However, which sensory fibers are affected remains unknown. The objective of this study was to examine the function of sensory nerve fibers in patients with cirrhosis using the current perception threshold (CPT) test, as well as the correlation between blood biochemical indicators related to cirrhosis and
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Diffusion-weighted Imaging Detection of Acute Ischemia Brain Lesions in Spontaneous Intracerebral Hemorrhage Associated with White Matter Hyperintensities, Enlarged Perivascular Spaces and Diabetes Mellitus Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-29 Yutong Hou, Wei Qin, Shuna Yang, Yue Li, Lei Yang, Wenli Hu
Objective: Diffusion-weighted imaging [DWI] is commonly detected after spontaneous intracerebral hemorrhage [sICH] and is associated with poor functional outcomes. However, the etiology and significance of DWI lesions remain unclear. Thus, our study aimed to explore the prevalence and risk factors of acute ischemic lesions in sICH and discussed the possible mechanisms. Methods: We conducted a retrospective
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Bacterial Pneumonia and Stroke Risk: A Nationwide Longitudinal Followup Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-29 Joyce En-Hua Wang, Shih-Jen Tsai, Yen-Po Wang, Tzeng-Ji Chen, Tso-Jen Wang, Mu-Hong Chen
Background: Pneumonia causes significant morbidity and mortality and has been associated with cardiovascular complications. Our study aimed to investigate the incidence of ischemic and hemorrhagic strokes following bacterial pneumonia. Methods: Between 1997 and 2012, 10,931 subjects with bacterial pneumonia and 109,310 controls were enrolled from the Taiwan National Health Insurance Research Database
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Antidepressant Effect of Sodium Butyrate is Accompanied by Brain Epigenetic Modulation in Rats Subjected to Early or Late Life Stress Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-29 Samira Silva Valvassori, Roger Bitencourt Varela, Wilson Rodrigues Resende, Taise Possamai Della, Laura Araújo Borba, João Paulo Behenck, Gislaine Zilli Réus, João Quevedo
Background: Major depression has a complex and multifactorial etiology constituted by the interaction between genetic and environmental factors in its development. Objective: The aim of this study was to evaluate the effects of sodium butyrate (SD) on epigenetic enzyme alterations in rats subjected to animal models of depression induced by maternal deprivation (MD) or chronic mild stress (CMS). Methods:
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Association between plasma brain-derived neurotrophic factor level and Alzheimer’s disease: a Mendelian randomization study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-26 Jiaxing You, Yinan Wang, Xinyue Chang, Yi Liu, Yu He, Xiya Zhou, Jinyan Zou, Meng Xiao, Mengyao Shi, Daoxia Guo, Ouxi Shen, Zhengbao Zhu
Background: High brain-derived neurotrophic factor (BDNF) concentrations have been found to be associated with a decreased risk of Alzheimer’s disease (AD) in observational studies, but the causality for this association remains unclear. Therefore, we aimed to examine the association between genetically determined plasma BDNF levels and AD using a two-sample Mendelian randomization (MR) method. Methods:
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Correlation of Circadian Rhythms and Improvement of Depressive Symptoms in Acute Ischemic Stroke Patients Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2024-01-26 Yue Ding, Shengnan Chen, Qian Sun, Fei Han, Rui Chen, Jie Li
Objectives:: To investigate the correlation between evening melatonin timing secretion, dim light melatonin onset (DLMO), and post-stroke depression (PSD) in acute ischemic stroke (AIS) patients and their influence on the improvement of depressive symptoms. Materials and Methods:: 120 patients with a recent magnetic resonance imaging confirmed stroke were included. Salivary melatonin samples were collected
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The Safety and Efficacy of Leo Stents with Coiling or Alone for Anterior cerebral Artery Aneurysms Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-27 Yu Duan, Jun Shen, Xuanfeng Qin, Binbin Xu, Renling Mao, Jian Li, Qinzhu An, Yujun Liao, Fayong Zhang, Gong Chen
Introduction: Treatment of anterior cerebral artery (ACA) aneurysms is still not well established. The Leo stent with blood flow direction is a retrievable stent for intracranial aneurysms, whereas it needs to be studied clearly in patients with ACA aneurysms. Methods: Consecutive patients with ACA aneurysms were retrospectively enrolled in three neurosurgical centers between January 2016 and October
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Causal Effects of Blood Metabolites and Obstructive Sleep Apnea: A Mendelian Randomization Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-27 Jinghao Wu, Yinghao Yang, Yun chao wang, Wen Kai Yu, Shanshan Li, Yunyun Mei, Ce Zong, Zi Han Zhou, HangHang Zhu, LiuChang He, XinYu Li, ChangHe Shi, Yusheng Li
Background: Obstructive sleep apnea (OSA) is one of the most common forms of sleep-disordered breathing. Studies have shown that certain changes in metabolism play an important role in the pathophysiology of OSA. However, the causal relationship between these metabolites and OSA remains unclear. background: Obstructive sleep apnea (OSA) is one of the most common forms of sleep-disordered breathing
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Predicting Futile Recanalization in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: The Role of White Blood Cell Count to Mean Platelet Volume Ratio Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-23 Wantong Yu, Milan Jia, Wenting Guo, Jiali Xu, Changhong Ren, Sijie li, Wenbo Zhao, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Xunming Ji
Background:: Approximately half of AIS patients have an unfavorable outcome even after complete reperfusion. White blood cell (WBC) count to mean platelet volume (MPV) ratio (WMR) may be a promising predictive factor for futile recanalization. This study aimed to determine the predictive value of WMR in identifying individuals at higher risk of futile recanalization. Methods:: In this retrospective
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Correlation between Carotid Blood Flow Velocity and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease in Patients with Recent Small Subcortical Infarcts Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-15 Yi-Jun lv, Min Zhang, Wen-Wei Yun, Qing-Xiu Zhang, Jing-Wei LI
Background: The common and internal carotid arteries are the upstream vessels of the small cerebral vessels. The relationship between hemodynamic changes in the significant cervical vessels and cerebral small vessel disease (CSVD) remains uncertain. This research sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance imaging (MRI) burden of CSVD in patients
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The Association between Serum Total Bilirubin and Severe Headaches or Migraine in American Adults Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-15 Yuting He, Hao Huang, Lingao Dai, Xiaoping Wang
Background: Studies about the association between bilirubin and migraine were few. Therefore, the purpose of this study was to investigate the association between serum total bilirubin and the prevalence of severe headaches or migraine. Methods: A multivariable logistic regression was used to assess the association between serum total bilirubin concentration and severe headaches or migraine. We also
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Albumin-Globulin Ratio and Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-15 Qiao Han, Shoujiang You, Mengyuan Miao, Danni Zheng, Huaping Du, Yaming Sun, Wanqing Zhai, Chongke Zhong, Yongjun Cao, Chun-Feng Liu
Background: The relationships between serum albumin, albumin-globulin (A/G) ratio, globulin and atherosclerosis in acute ischemic stroke (AIS) remain uncertain. We investigated the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis in patients with AIS. background: The relationships between serum albumin, albumin-globulin (A/G) ratio, globulin and atherosclerosis
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Association between Peripheral Arterial Lactate Levels and Malignant Brain Edema Following Endovascular Treatment for Ischemic Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-15 Huiyuan Wang, Ruozhen Yuan, Panpan Shen, Xinyue Yu, Xinyi Chen, Yafei Shang, Jie Xu, Mingming Tan, Sheng Zhang, Yu Geng
Aims: To investigate the factors of postoperative malignant brain edema (MBE) in patients with acute ischemic stroke (AIS) treated with endovascular treatment (EVT). Background: MBE is a severe complication following EVT for AIS, and it is essential to identify risk factors early. Peripheral arterial lactate (PAL) levels may serve as a potential predictive marker for MBE. Objective: To determine whether
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Gait Parameters can Reflect Cognitive Performance in Older Adults with Cerebral Small Vessel Disease: A Cross-sectional Research Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-15 Mingzhu Jiang, Yan Li, Ying Chen, Jinying Fan, Zhiqin Zhao, Wenkai Long, Hailun Huang, Fang Luo, Chao Tang, Mi Li, Ning Xiao, Bo Lin, Shan Wu, Jing Ding
Background: Cerebral small vessel disease (CSVD) is a common chronic progressive disease. It remains unclear whether high gait variability is a marker of cognitive cortical dysfunction. Methods: This study included 285 subjects (aged from 60 to 85 years, 60.3% female) including 37 controls, 179 presented as Fazekas II, and 69 presented as Fazekas III. The severity of white matter hyperintensities was
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Association of Cardiac Valve Calcification and 1-year Mortality after Lower-extremity Amputation in Diabetic Patients: A Retrospective Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-12 Weibin Ye, Li Li, Jianfeng Zeng
Background: Cardiac valve calcification predisposes patients to a higher risk of adverse cardiovascular events. This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation. Methods: This was a retrospective study conducted on the clinical data of diabetic patients who underwent lower-extremity amputation
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The Effect of Remote Ischemic Postconditioning on Quality of Life and Clinical Events after an Ischemic Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-12-01 Thijs P. Kerstens, Thijs R.J. Landman, Yvonne Schoon, Frederick J.A. Meijer, Michiel C. Warlé, Frank-Erik de Leeuw, Dick H.J. Thijssen
Objectives: Repeated remote ischemic postconditioning (rIPostC) may be an easily applicable treatment following ischemic stroke to improve quality of life (QoL) and clinical outcomes. rIPostC consists of repeated, brief periods of limb ischemia (through inflation of a blood pressure cuff), followed by reperfusion. This study investigated the 1-year follow-up of rIPostC on QoL and clinical events. Methods:
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Assessment of the Roles of Magnesium and Zinc in Clinical Disorders Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-11-27 David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Armando Valenzuela Peraza, Ernestina Hernández Garcia, Gerardo Barragán Mejía, Hugo Juarez Olguin
The ability and facility of magnesium (Mg2+) and zinc (Zn2+) to interact with phosphate ions confer them the characteristics of essential trace elements. Trace elements are extremely necessary for the basic nucleic acid chemistry of cells of all known living organisms. More than 300 enzymes require zinc and magnesium ions for their catalytic actions, including all the enzymes involved in the synthesis
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Intravenous Thrombolysis is Effective in Mild Stroke Patients with an Admission NIHSS Score of 3 to 5 Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-31 Kai Zhang, Lin Han
Background and Purpose: The role of intravenous thrombolysis in patients with acute mild ischemic stroke remains highly controversial. Therefore, this study aims to analyze the efficacy and safety of intravenous thrombolysis in patients with mild ischemic stroke based on admission National Institutes of Health Stroke Scale (NIHSS) score. Methods: The present study enrolled 507 patients with acute mild
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Pan-Immune-Inflammatory Value Predicts the 3 Months Outcome in Acute Ischemic Stroke Patients after Intravenous Thrombolysis Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-25 Shan Wang, Lulu Zhang, Huan Qi, Lulu Zhang(F), Qi Fang, Lanfeng Qiu
Background and Purpose: Immune and inflammatory response plays a central role in the clinical outcomes of stroke. This study is aimed to explore the clinical significance of the new inflammation index named pan-immune-inflammation value (PIV) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis therapy (IVT). Methods: Data were collected from 717 patients who received IVT at
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Smurf2-Mediated Ubiquitination of FOXO4 Regulates Oxygen-glucose Deprivation/Reperfusion-induced Pyroptosis of Cortical Neurons Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-12 Bin Yan, Yan Jin, Song Mao, Yi Zhang, Dahong Yang, Mingyang Du, Yugang Yin
Background: Smad ubiquitination regulatory factor 2 (Smurf2) has been observed to alleviate ischemia-reperfusion injury. This study sought to explore the molecular mechanism of Smurf2-mediated forkhead box O4 (FOXO4) ubiquitination in oxygen-glucose deprivation/ reperfusion (OGD/R)-induced pyroptosis of cortical neurons. Methods: Human cortical neurons (HCN-2) were subjected to OGD/R to establish a
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Bone Marrow Mesenchymal Stem Cell Exosomal miR-345-3p Ameliorates Cerebral Ischemia-reperfusion Injury by Targeting TRAF6 Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-06 Dan Hou, Lei Zhang, Yujie Hu, Guoshuai Yang, Dan Yu
Introduction: The purpose of this study was to investigate the effects of bone marrow mesenchymal stem cells (BMSCs) exosomal miR-345-3p and tumor necrosis factor receptorassociated factor 6 (TRAF6) on cerebral ischemia reperfusion (CIR) injury. Exosomes (Exos) derived from BMSCs were isolated and identified. PC12 (rat pheochromocytoma) cells were used to establish an oxygen and glucose deprivation/reoxygenation
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Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-reperfusion Injury by Down-regulating Mir-155-5p Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-06 Xuejing Li, Ying Wang, Xiang Zhou, Hui Wang, Jiang Xu
Background: Increasing evidence shows that electroacupuncture pretreatment (EP) plays a crucial role in cerebral ischemia-reperfusion (I/R) injury, and cerebral I/R injury is the most serious complication of ischemic stroke treatment. The role of miR-155-5p in cerebral I/R injury has been studied, but the regulation of EP on miR-155-5p has not been reported. Methods: The middle cerebral artery occlusion
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Targeting the AKT/mTOR/p70S6K Pathway for Oligodendrocyte Differentiation and Myelin Regeneration in Neurological Disorders Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-10-04 Chen Ge, Changwei Li
Background: The AKT/mTOR/p70S6K pathway has been shown to potentially promote spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to be further explored. Objective: This study aims to explore the AKT/mTOR/p70S6K pathway in oligodendrocyte precursor cell (OPC) differentiation, microglial polarization differentiation, and the role of these in myelin regeneration in
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Modified Risk of Paradoxical Embolism More Effectively Evaluates the Risk of Stroke Associated with Patent Foramen Ovale Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-28 Yun Wang, Tun Zhao, Yajun Ma, Wenli Hu
Background: Through an analysis of the risk factors associated with patent foramen ovale (PFO)-related stroke (PS), we aimed to modify the Risk of Paradoxical Embolism (RoPE) to assess the risk of PS. Methods: A retrospective collection of ischemic stroke (IS) patients with PFO admitted to the Department of Neurology at Beijing Chaoyang Hospital was conducted. The patients were classified into PS and
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Wheel Running Adversely Affects Disease Onset and Neuromuscular Interplay in Amyotrophic Lateral Sclerosis Slow Progression Mouse Model Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-28 Elisabetta Golini, Sara Marinelli, Simona Pisu, Federica De Angelis, Valentina Vacca, Alessandro Rava, Irene Casola, Gaia Laurenzi, Emanuele Rizzuto, Alessandro Giuliani, Antonio Musarò, Gabriella Dobrowolny, Silvia Mandillo
Background: Physical activity in Amyotrophic Lateral Sclerosis (ALS) plays a controversial role. In some epidemiological studies, both recreational or professional sport exercise has been associated to an increased risk for ALS but the mechanisms underlying the effects of exercise have not been fully elucidated in either patients or animal models. Methods: To better reproduce the influence of this
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The Positional Relationship between Lacunae and White Matter Hyperintensity in Patients with Cerebral Small Vessel Disease Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-28 Lu An, Wenxin Yuan, Yunchao Wang, Shanshan Li, Ce Zong, Yuan Gao, Yusheng Li, Limei Wang, Ya peng Li, Yan Ji, Yuming Xu
Background: Lacunae and white matter hyperintensity (WMH) are two crucial imaging biomarkers of cerebral small vessel disease (CSVD). Multiple studies have revealed a close relationship between WMH and lacunae and found that a double penumbra existed at the edge of WMH that affects lacunae formation. The study aimed to explore the spatial distribution characteristics and possible influencing factors
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Prognostic Value of Red Blood Cell Distribution Width and Hemoglobin in Patients with Spontaneous Intracerebral Hemorrhage Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-25 Jiaping Xu, Xin Sun, Weiyin Cao, Huan Wu, Xinjia Pan, Linchi Wang, Yi Zhou, Wanqing Zhai, Shoujiang You, Yongjun Cao
Background: The association between baseline red blood cell distribution width (RDW) and hemoglobin levels and outcomes after acute intracerebral hemorrhage (ICH) is not well studied. We aimed to investigate the association between baseline RDW and hemoglobin levels with early hematoma expansion (HE) and mortality at 3 months and 1 year in acute ICH patients. Methods: A total of 393 ICH patients from
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Major Targets Involved in Clinical Management of Migraine Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-24 Rapuru Rushendran, Vellapandian Chitra, Kaliappan Ilango
Background: There has been a protracted effort to identify reliable targets for migraine. It is believed that each year, hundreds of millions of individuals worldwide suffer from migraines, making this widespread neurological ailment the second leading cause of years of disability worldwide. The rationale of this study is to identify the major targets involved in migraine attacks. Methods: For this
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The Association of the Spatial Location of Contrast Extravasation with Symptomatic Intracranial Hemorrhage after Endovascular Therapy in Acute Ischemic Stroke Patients Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-24 Chen Gong, You Wang, Jinxian Yuan, Jie Zhang, Shuyu Jiang, Tao Xu, Yangmei Chen
Background: Contrast extravasation (CE) on brain non-contrast computed tomography (NCCT) after endovascular therapy (EVT) is commonly present in patients with acute ischemic stroke (AIS). Substantial uncertainties remain about the relationship between the spatial location of CE and symptomatic intracranial hemorrhage (sICH). Therefore, this study aimed to evaluate this association. Methods: We performed
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The Study of Risk Factors and The Predict Model of Cerebral Microbleeds Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-24 Tao Lv, Changqing Li
Background: To determine the association of cardiovascular risk factors with the presence and anatomic location of CMBs and construct a factor-based evaluating model to predict a high CMBs burden. Methods: We assessed the relation of age, male, various cardiovascular risk factors, medication use, stroke histories and white matter hyperintensities (WMH) to the presence and location of CMBs with univariate
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Electroacupuncture Inhibits Ferroptosis Induced by Cerebral Ischemiareperfusion Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-24 Gui-Ling Wang, Shu-Ying Xu, He-Qun Lv, Chao Zhang, Yong-Jun Peng
Background: Electroacupuncture (EA) treatment has been recommended by World Health Organization (WHO) for years on cerebral ischemia treatment, but the specific mechanism is still elusive. Studies have shown that EA can relieve brain damage after ischemic stroke by inhibiting programmed cell death (PCD), such as apoptosis, necroptosis, and autophagy. Ferroptosis, a unique form of cell death, has been
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Smoking, Coffee Consumption, Alcohol Intake, and Obstructive Sleep Apnea: A Mendelian Randomization Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-23 Yusheng Li, Yinghao Yang, Jinghao Wu, Shanshan Li, Wenkai Yu, Hanghang Zhu, Yunchao Wang
Background: Previous studies revealed that obstructive sleep apnea (OSA) and smoking, alcohol consumption, and coffee intake are closely related. This study aimed to evaluate the causal effect between these factors and OSA. Method: The published genome-wide association study data (GWAS) provided genetic tools. We conducted a univariable two-sample Mendelian Randomization (MR) to estimate the causal
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Genome-wide Association Studies of REST Gene Associated Neurological Diseases/traits with Related Single Nucleotide Polymorphisms Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-22 Jingjing Wang, Sagor Kumar Roy, Seidu A. Richard, Yuming Xu
Background: Genome-wide association studies (GWAS) have been used to explore the connections between genotypes and phenotypes by comparing the genotype frequencies of genetic changes in individuals with similar origins but distinct traits. Objectives: The aim is to employ the GWAS catalog to identify and investigate the various correlations between genotypes and phenotypes of the REST gene. Methods:
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The Effect of Dexamethasone on Lipopolysaccharide-induced Inflammation of Endothelial Cells of the Blood-brain Barrier/Brain Capillaries Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-18 Tershlin Jeftha, Khayelihle Brian Makhathini, David Fisher
Background: A protective and regulatory barrier between the blood and the brain is constituted by the blood-brain barrier (BBB), which comprises microvascular endothelial cells providing homeostatic regulation of the central nervous system (CNS). Inflammation compromises the BBB and contributes to many CNS disorders. Anti-inflammatory effects are exerted by glucocorticoids (GCs) on a variety of cells
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Malignant Middle Cerebral Artery Infarction during Early versus Late Endovascular Treatment in Acute Ischemic Stroke Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-03 Wenting Guo, Ning Li, Jiali Xu, Jin Ma, Sijie Li, Changhong Ren, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
Introduction: Endovascular treatment (EVT) performed in the early time window has been shown to decrease the incidence of malignant middle cerebral artery infarction (MMI). However, the incidence of MMI in patients undergoing EVT during the late time window is unclear. This study aimed to investigate the prevalence of MMI in patients undergoing late EVT and compare it with that in patients undergoing
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Myasthenia Gravis and Ischemic Stroke: A Bidirectional Mendelian Randomization Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-03 Chen Liu, Chengyuan Mao, Shen Li, Yun Su, Hongbing Liu, Xin Wang, Weishi Liu, Jiawei Zhao, Xuyang Liu, Yuming Xu
Background: Autoimmune diseases are associated with cardiovascular and cerebrovascular diseases. However, whether myasthenia gravis (MG) and ischemic stroke (IS) are causally related remains unclear. Objectives: This study aimed to evaluate potential causal links between MG and IS using bidirectional Mendelian randomization (MR). Methods: We conducted a two-sample MR analysis to assess the potential
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Vulnerable Carotid Plaque is Associated with an Increased Risk of Intracerebral Hemorrhage in Individuals at High Risk of Stroke: A Chinese Population-based Cohort Study Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-08-01 Jie Li, Ping Zhang, Hong Chen, Ting Qing, Yanfen Wang, Ju Zhou, Xingyang Yi, Chun Wang
Objectives: To assess the association between carotid artery plaques and the risk of incident intracerebral hemorrhage (ICH) event in high-risk individuals for stroke. Methods: We conducted a population-based cohort study using the longitudinal participant-level data of a multicenter, cross-sectional survey in southwestern China. 2644 high-risk participants for stroke were enrolled in the year 2015
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The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-07-26 Kenneth Maiese
Disorders of metabolism affect multiple systems throughout the body but may have the greatest impact on both central and peripheral nervous systems. Currently available treatments and behavior changes for disorders that include diabetes mellitus (DM) and nervous system diseases are limited and cannot reverse the disease burden. Greater access to healthcare and a longer lifespan have led to an increased
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Ubiquitin-specific protease 8 regulates cognitive dysfunction of mice with sepsis-associated encephalopathy through SIRT1 deubiquitination Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-07-13 Zuoxiao Li, Weina Gao, Lijuan Wang
Background: Sepsis-associated encephalopathy (SAE) is the most severe complication of sepsis. Ubiquitin-specific protease 8 (USP8) could improve cognitive and motor disorders in SAE. Objective: This study explored the mechanism of USP8 in SAE mice to provide new therapeutic targets for SAE. Methods: C57BL/6 mice were selected to establish SAE models by caecal ligation and puncture (CLP) and injected
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Association of Blood Lipid Profile Components with White Matter Hyperintensity Burden in Cerebral Small Vessel Disease Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-07-12 Shanshan Li, Yunchao Wang, Lulu Yu, Yuan Gao, Yinghao Yang, Hanghang Zhu, Lu An, Wenxin Yuan, Jinghao Wu, Ce Zong, Yuming Xu, Yusheng Li
Background: Cerebral small vessel disease (CSVD) refers to a common cerebrovascular disease and white matter hyperintensities (WMHs) constitute a typical feature of CSVD. However, there has not been a large number of studies investigating the relationship between lipid profile components and WMHs. Methods: Altogether, 1019 patients with CSVD were enrolled at the First Affiliated Hospital of Zhengzhou
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Low-frequency Electrical Stimulation of the Hippocampus Plays a Role in the Treatment of Pharmacoresistant Epilepsy by Blocking the PKA-CREB Pathway Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-23 Yuanxin Huang, Dai Shi, Guofeng Wu, Likun Wang, Siying Ren
Objective: The objective of this study is to study the mechanism of Low frequency electrical stimulation (LFS) in the treatment of drug-resistant epilepsy by regulating the protein kinase A (PKA)-cAMP response element-binding protein (CREB) signaling pathway upstream of gamma aminobutyric acid A (GABAA) receptor. Methods: Primary hippocampal neurons were extracted and cultured from fetal rat brains
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Regulatory Effect of Electroacupuncture on Hypothalamic Serotonin and its Receptor in Rats with Cerebral Ischemia Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-23 Tongjun Ma, Chenyu Li, Zeyin Nie, Huachun Miao, Feng Wu
Background: Previous studies have shown that the neurological damage caused by middle cerebral artery occlusion (MCAO) is not only limited to local infarction but can also cause secondary damage in distant sites, such as the hypothalamus. 5-hydroxytryptamine (5-HT)/ 5-HT transporter (5-HTT) and 5-HT receptor 2A (5-HT2A) are important in the treatment of cerebrovascular diseases. Objective: This study
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Establishment of a Rat Model of Infraorbital Neuroinflammation Under CT Guidance Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-23 Chen Zeng, Chuan Zhang, Ruhui Xiao, Yehan Li, Xing Luo, Hao Deng, Hanfeng Yang
Introduction: The aim is to establish a rat model of infraorbital neuroinflammation with less trauma, stable pain, and a long duration of pain. The pathogenesis of TN is not fully clear. There are various models of TN in rats with different disadvantages, such as damaging the surrounding structures and inaccuracy of location for infraorbital nerve (ION). We aim to establish a rat model of infraorbital
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Combined Role of Inflammatory Biomarkers and Red Blood Cell Distribution Width in Predicting In-hospital Outcomes of Acute Ischemic Stroke Patients Undergoing Thrombolysis Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-14 Yi Wang, Yafang Zhu, Xiaohong Wang, Chongke Zhong, Yan Qin, Yongrong Sun, Yongjun Cao, Xia Zhang, Dongqin Chen
Background: To investigate the combined effect of red blood cell distribution width (RDW) and inflammatory biomarkers on in-hospital outcomes of acute ischemic stroke(AIS) patients with thrombolysis. Methods: 417 AIS patients with thrombolysis were included. The participants were divided into four groups according to the cut-off of white blood cell (WBC) or C reactive protein (CRP) and RDW: LWLR, LWHR
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The Relationship Between Triglyceride Glucose Index and Migraine: A Cross-Section Study from the National Health and Nutrition Examination Survey (NHANES) Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-14 Yao Liu, Xiaochuan Gao, Lingmei Yuan, Yanming Li, Peiwei Hong
Background: Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus. Some previous studies have found an association between insulin resistance and migraine. The triglyceride glucose (TyG) index is used to assess insulin resistance. However, there is no report on the association between the TyG index and
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DDX3X Deficiency Attenuates Pyroptosis Induced by Oxygen-glucose Deprivation/Reoxygenation in N2a Cells Curr. Neurovasc. Res. (IF 2.1) Pub Date : 2023-06-14 Yong Liu, Yanlin Gui, Hao Tang, Jianping Yu, Zhengzhou Yuan, Lei Liu, Xuntai Ma, Changqing Li
Background: NOD‑like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis is strongly related to cerebral ischemia/reperfusion (I/R) injury. DDX3X, the DEAD-box family's ATPase/RNA helicase, promotes NLRP3 inflammasome activation. However, whether DDX3X deficiency attenuates NLRP3 inflammasome-mediated pyroptosis induced by cerebral I/R injury. Objectives: This study investigated whether DDX3X