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Association between Life’s Essential 8 and Cerebral Small Vessel Disease Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-20 Dandan Liu, Xueli Cai, Yingying Yang, Suying Wang, Lerong Mei, Jing Jing, Shan Li, Mengxing Wang, Yun Chen, Xia Meng, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan
Background Given that associations of Life’s Essential 8 (LE8) and cerebral small vessel disease (CSVD) or its imaging markers were unclear, we examined relationship between them. Methods The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study. We calculated the total LE8 score, medical LE8 score and behavioural score
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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yunke Li, Sung-Min Cho, Radhika Avadhani, Hassan Ali, Yi Hao, Santosh B Murthy, Joshua N Goldstein, Fan Xia, Xin Hu, Natalie L Ullman, Issam Awad, Daniel Hanley, Wendy C Ziai
Background Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral haemorrhage (ICH) is controversial but may be beneficial if end-of-treatment (EOT) haematoma volume is reduced to ≤15 mL. We explored whether MRI findings of cerebral small vessel disease (CSVD) modify the effect of MIS on long-term outcomes. Methods Prespecified blinded subgroup analysis of 288 subjects with qualified
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Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 An Tian, Ziwei Cui, Jian Ren, Yeqing Ren, Ming Ye, Guilin Li, Chuan He, Xiaoyu Li, Gao Zeng, Peng Hu, Yongjie Ma, Jiaxing Yu, Jingwei Li, Lisong Bian, Fan Yang, Qianwen Li, Feng Ling, Tao Hong, Liyong Sun, Hongqi Zhang
Background Surgical resection of the lesions remains the main treatment method for most symptomatic spinal cord cavernous malformations (SCCMs) to eliminate the occupation and associated subsequent lifelong haemorrhagic risk. However, the timing of surgical intervention remains controversial, especially for patients in the acute stage after severe haemorrhage. Methods Patients diagnosed with SCCMs
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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yujia Jin, Yu-hui Huang, Yu-ping Chen, Yao-dan Zhang, Jiawen Li, Kai-cheng Yang, Xianghua Ye, Lu-hang Jin, Jian Wu, Chang-zheng Yuan, Feng Gao, Lu-sha Tong
Background and purpose Cortical superficial siderosis (cSS) and cerebral microbleed (CMB) have distinct effects on intracerebral haemorrhage (ICH). We aim to investigate the combined effect of cSS and CMB on outcomes after ICH. Methods Based on a single-centre stroke registry database, patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were identified. Eligible
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Time to treat the climate and nature crisis as one indivisible global health emergency Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-25 Chris Zielinski
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and
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Longitudinal associations of cardiovascular health and vascular events with incident dementia Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-21 Ya-Nan Ou, Kevin Kuo, Liu Yang, Ya-Ru Zhang, Shu-Yi Huang, Shi-Dong Chen, Yue-Ting Deng, Yu Guo, Rui-Qi Zhang, Bang-Sheng Wu, Lan Tan, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate the distinctive associations across different dementia types is still lacking. This study is sought to: (1) determine the clinical validity of Framingham General Cardiovascular Risk Score (FGCRS) for dementia assessment and (2) examine the associations
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Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-13 Xiumei Xu, Mingyu Chen, Dongya Zhu
Stroke is the second-leading cause of death and the leading cause of disability in much of the world. In particular, China faces the greatest challenge from stroke, since the population is aged quickly. In decades of clinical trials, no neuroprotectant has had reproducible efficacy on primary clinical end points, because reperfusion is probably a necessity for neuroprotection to be clinically beneficial
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Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-12 Dapeng Sun, Xinguang Yang, Xiaochuan Huo, Raynald, Baixue Jia, Xu Tong, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Zhongrong Miao
Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy (EVT) for acute vertebrobasilar artery occlusion (VBAO). Methods Participants of the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischaemic Stroke (ANGEL-ACT) registry were selected for the analysis. Futile recanalisation was defined as patients did not achieve
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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy? Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-06 Adam Ingleton, Marko Raseta, Rui-En Chung, Kevin Jun Hui Kow, Jake Weddell, Sanjeev Nayak, Changez Jadun, Zafar Hashim, Noman Qayyum, Phillip Ferdinand, Indira Natarajan, Christine Roffe
Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy (MT). Most patients undergoing MT are also given thrombolysis. Antiplatelet agents are contraindicated within 24 hours of thrombolysis. We evaluated outcomes and complications of patients stented with and without intravenous aspirin during MT. Methods All patients who underwent emergent
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Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Tianchi Tang, Li-bin Hu, Chao Ding, Zhihua Zhang, Ning Wang, Tingting Wang, Hang Zhou, Siqi Xia, Linfeng Fan, Xiong-jie Fu, Feng Yan, Xiangnan Zhang, Gao Chen, Jianru Li
Background Ischaemic stroke triggers neuronal mitophagy, while the involvement of mitophagy receptors in ischaemia/reperfusion (I/R) injury-induced neuronal mitophagy remain not fully elucidated. Here, we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1 (FUNDC1) and its modulation in neuronal mitophagy induced by I/R injury. Methods Wild-type and FUNDC1 knockout
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Stroke depression: a concept with clinical applicability Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Jun Mu, Arun V Ravindran, Pim Cuijpers, Yiqing Shen, Wensong Yang, Qi Li, Xinyu Zhou, Peng Xie
Stroke is a common neurological condition and among the leading causes of death and disability worldwide. Depression is both a risk factor for and complication of stroke, and the two conditions may have a complex reciprocal relationship over time. However, the secondary effects of depression on stroke are often overlooked, resulting in increased morbidity and mortality. In the previous concept of ‘poststroke
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Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Hae Rang Kim, Min Jeoung Kim, Sunyeup Kim, Myung Soo Chang, Dong Joon Kim, Byung Moon Kim, Keun Young Park, Yong Bae Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Background To evaluate the association between retinal artery/arteriole occlusion (RAO) and unruptured intracranial aneurysm (UIA). Methods Incident UIA patients from a nationwide cohort (n=253 240) were categorised into three groups based on subsequent treatment: observation (n=208 993), microsurgical clipping (n=14 168) and endovascular treatment (EVT) groups (n=30 079). The incidence and the incident
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Advanced rehabilitation in ischaemic stroke research Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-03 Jixian Wang, Yongfang Li, Lin Qi, Muyassar Mamtilahun, Chang Liu, Ze Liu, Rubing Shi, Shengju Wu, Guo-Yuan Yang
At present, due to the rapid progress of treatment technology in the acute phase of ischaemic stroke, the mortality of patients has been greatly reduced but the number of disabled survivors is increasing, and most of them are elderly patients. Physicians and rehabilitation therapists pay attention to develop all kinds of therapist techniques including physical therapy techniques, robot-assisted technology
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One-year direct and indirect costs of ischaemic stroke in China Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-03 Wei Lv, Anxin Wang, Qianyi Wang, Ruimin Wang, Qin Xu, Shuqing Wu, Yi Han, Yong Jiang, Jinxi Lin, Jing Jing, Hao Li, Yongjun Wang, Xia Meng
Background This is the first real-world study to estimate the direct costs and indirect costs of first-ever ischaemic stroke with 1-year follow-up in China, based on a nationally representative sample. Methods Patients were chosen from 20 geographically diverse sites from the nationally representative database China National Stroke Registry-III (CNSR-III). The inclusion criteria were surviving patients
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Group 2 innate lymphoid cells resolve neuroinflammation following cerebral ischaemia Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Pei Zheng, Yuwhen Xiu, Zhili Chen, Meng Yuan, Yan Li, Ningning Wang, Bohao Zhang, Xin Zhao, Minshu Li, Qiang Liu, Fu-Dong Shi, Wei-Na Jin
Background Acute brain ischaemia elicits pronounced inflammation, which aggravates neural injury. However, the mechanisms governing the resolution of acute neuroinflammation remain poorly understood. In contrast to regulatory T and B cells, group 2 innate lymphoid cells (ILC2s) are immunoregulatory cells that can be swiftly mobilised without antigen presentation; whether and how these ILC2s participate
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Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Yu Tian, Xueli Cai, Yijun Zhou, Aoming Jin, Suying Wang, Yingying Yang, Lerong Mei, Jing Jing, Shan Li, Xia Meng, Tiemin Wei, Tao Liu, Yongjun Wang, Yuesong Pan, Yilong Wang
Objective This study aims to investigate the associations of glymphatic system with the presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) in a community-based population. Method This report included 2219 community-dwelling people aged 50–75 years who participated in the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events cohort. The diffusivity
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Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Tomáš Hrbáč, Jiří Fiedler, Václav Procházka, Tomáš Jonszta, Martin Roubec, David Pakizer, Daniel Václavík, David Netuka, Tomáš Heryán, David Školoudík
Background and aim In-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty and stenting in patients with severe carotid stenosis. Some of these patients might be contraindicated to repeat percutaneous transluminal angioplasty with or without stenting (rePTA/S). The purpose of the study is to compare the safety and effectiveness of carotid endarterectomy
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Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Yaning Xu, Chengchun Liu, Wei Li, Ximing Nie, Shuhan Huang, Xiaoshu Li, Ya Wu, Wang-Sheng Jin, Jiaojin Jiang, Jun Dong, Yi Yang, Zhiqiang Sun, Wenjun Han, Yanjiang Wang, Liping Liu, Meng Zhang
Background The timing for initiating anticoagulant therapy in acute ischaemic stroke (AIS) patients with atrial fibrillation who recanalised after endovascular treatment (EVT) is unclear. The objective of this study was to evaluate the effect of early anticoagulation after successful recanalisation in AIS patients with atrial fibrillation. Methods Patients with anterior circulation large vessel occlusion
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Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Dan Wang, Zi-Yang Shang, Yu Cui, Ben-Qiang Yang, George Ntaios, Hui-Sheng Chen
Objective To determine the characteristics of intracranial plaque proximal to large vessel occlusion (LVO) in stroke patients without major-risk cardioembolic source using 3.0 T high-resolution MRI (HR-MRI). Methods We retrospectively enrolled eligible patients from January 2015 to July 2021. The multidimensional parameters of plaque such as remodelling index (RI), plaque burden (PB), percentage lipid-rich
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Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Yi Yang, Qiheng He, Yuanyuan Dang, Xiaoyu Xia, Xin Xu, Xueling Chen, Jizong Zhao, Jianghong He
Background Deep brain stimulation (DBS) has been preliminarily applied to treat patients with disorders of consciousness (DoCs). The study aimed to determine whether DBS was effective for treating patients with DoC and identify factors related to patients’ outcomes. Methods Data from 365 patients with DoCs who were consecutively admitted from 15 July 2011 to 31 December 2021 were retrospectively analysed
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Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Julián N Acosta, Stefan P Haider, Cyprien Rivier, Audrey C Leasure, Kevin N Sheth, Guido J Falcone, Seyedmehdi Payabvash
Background and objectives We aimed to investigate the white matter (WM) microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure (SBP), and whether they mediate SBP effects on cognitive performance in middle-aged adults. Methods Using the UK Biobank study of community-dwelling volunteers aged 40–69 years, we included participants without a history of stroke, dementia
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Loss of life expectancy due to stroke and its subtypes in urban and rural areas in China, 2005–2020 Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Zixin Wang, Wei Liu, Yi Ren, Chen Zhang, Jia Yang, Lijun Wang, Maigeng Zhou, Peng Yin, Junwei Hao, Qingfeng Ma
Stroke is characterised by high mortality and disability rate in China. This study aimed to explore the temporal trends in years of life lost (YLL) and loss of life expectancy due to stroke and its subtypes in urban and rural areas in China during 2005–2020. Data were obtained from China National Mortality Surveillance System. Abbreviated life and stroke-eliminated life tables were generated to calculate
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Retinal microvascular signs and recurrent vascular events in patients with TIA or minor stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-01 Philipp Klyscz, Thomas Ihl, Inga Laumeier, Maureen Steinicke, Matthias Endres, Georg Michelson, Heinrich J Audebert
Background and purpose Retinal pathologies are an independent risk factor for ischaemic stroke, but research on the predictive value of retinal abnormalities for recurrent vascular events in patients with prior stroke is inconclusive. We investigated the association of retinal pathologies with subsequent vascular events. Methods In a substudy of the Intensified secondary prevention intending a reduction
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Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-09-12 Gabriel Broocks, Lukas Meyer, Uta Hanning, Tobias Djamsched Faizy, Matthias Bechstein, Helge Kniep, Noel Van Horn, Gerhard Schön, Ewgenia Barow, Götz Thomalla, Jens Fiehler, Andre Kemmling
Background and purpose In wake-up stroke, CT-based quantitative net water uptake (NWU) might serve as an alternative tool to MRI to guide intravenous thrombolysis with alteplase (IVT). An important complication after IVT is symptomatic intracerebral haemorrhage (sICH). As NWU directly implies ischaemic lesion progression, reflecting blood-brain barrier injury, we hypothesised that NWU predicts sICH
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White matter disease derived from vascular and demyelinating origins Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-09-12 Lin-Jie Zhang, De-Cai Tian, Li Yang, Kaibin Shi, Yaou Liu, Yilong Wang, Fu-Dong Shi
Damage or microstructural alterations of the white matter can cause dysfunction of the intrinsic neural networks in a condition termed as white matter disease (WMD). Frequently detected on brain computed tomography and magnetic resonance imaging scans, WMD is commonly presented in inflammatory demyelinating diseases like multiple sclerosis (MS) and vascular diseases such as cerebral small vessel disease
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Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-09-12 Zixiao Li, Xinmiao Zhang, Lingling Ding, Jing Jing, Hong-Qiu Gu, Yong Jiang, Xia Meng, Chunying Du, Chunjuan Wang, Meng Wang, Man Xu, Yanxu Zhang, Meera Hu, Hao Li, Xiping Gong, Kehui Dong, Xingquan Zhao, Yilong Wang, Liping Liu, Ying Xian, Eric Peterson, Gregg C Fonarow, Lee H Schwamm, Yongjun Wang
Background Given the swift advancements in artificial intelligence (AI), the utilisation of AI-based clinical decision support systems (AI-CDSSs) has become increasingly prevalent in the medical domain, particularly in the management of cerebrovascular disease. Aims To describe the design, rationale and methods of a cluster-randomised multifaceted intervention trial aimed at investigating the effect
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Individualised evaluation based on pathophysiology for moyamoya vasculopathy: application in surgical revascularisation Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-30 Xin Zhang, Yu Lei, Jiabin Su, Chao Gao, Yanjiang Li, Rui Feng, Ding Xia, Peng Gao, Yuxiang Gu, Ying Mao
Background Although bypass surgery is an effective treatment for moyamoya vasculopathy (MMV), the incidence of postoperative complications is still high. This study aims to introduce a novel evaluating system based on individualised pathophysiology of MMV, and to assess its clinical significance. Methods This multicentre, prospective study enrolled adult patients with MMV from Huashan Hospital, Fudan
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Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on ‘Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-28 Alexander Sirakov, Georgi Vladev, Kristina Sirakova, Kristian Ninov, Krasimir Minkin, Vasil Karakostov, Stanimir Sirakov
In the treatment of symptomatic intracranial aneurysms, the study by Zhao et al stands as a notable addition to the growing body of literature.1 Their investigation regarding the Pipeline Embolisation Device’s (PED, Covidien/Medtronic, Irvine, California, USA) efficacy in alleviating mass effect offers valuable insights that further contribute to the evolving landscape of neurointerventional therapy
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Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-28 Ying Yu, Yake Lou, Yuesong Pan, Long Yan, Weilun Fu, Zhikai Hou, Rongrong Cui, Zhongrong Miao, Yongjun Wang, Xin Lou, Ning Ma
Background and purpose Residual inflammatory risk (RIR) can predict the unfavourable outcomes in patients with minor ischaemic stroke. However, the impact of preprocedural RIR on long-term outcomes in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) who underwent stenting remains understudied. Methods This retrospective, single-centre cohort study evaluated consecutive patients
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Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-28 Songchun Yang, Zhijia Sun, Dong Sun, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Yan Lu, Sushila Burgess, Daniel Avery, Robert Clarke, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv
Background and purpose Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population. Methods Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training
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Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-28 Yunyun Xiong, Liyuan Wang, Guangshuo Li, Kai-Xuan Yang, Manjun Hao, Shuya Li, Yuesong Pan, Yongjun Wang
Background Tenecteplase (TNK) was found non-inferior to alteplase in recent clinical trials. We aimed to elucidate the efficacy and safety of TNK versus alteplase for acute ischaemic stroke (AIS). Methods Systematic literature search and a meta-analysis of phase III clinical trials in ischaemic stroke patients with TNK use were conducted. The primary outcome was excellent functional outcome which was
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APE1 regulates mitochondrial DNA damage repair after experimental subarachnoid haemorrhage in vivo and in vitro Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-23 Kun Dai, Zongqi Wang, Bixi Gao, Longyuan Li, Feng Gu, Xinyu Tao, Wanchun You, Zhong Wang
Background [Subarachnoid haemorrhage][1] (SAH) can result in a highly unfavourable prognosis. In recent years, the study of SAH has focused on early brain injury (EBI), which is a crucial progress that contributes to adverse prognosis. SAH can lead to various complications, including mitochondrial dysfunction and DNA damage. Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein with multifaceted
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Efficacy and safety of a neurointerventional operation robotic assistance system in cerebral angiography Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-23 He Liu, Conghui Li, Shaohua Ren, Tong Li, Hongliang Zhong, Jianwen Jia, Hongchao Yang, Yi Qi, Junqiang Feng, Youxiang Li, Yang Wang
Background At present, neurointerventional surgery requires angiographers to perform operations in the digital subtraction angiography (DSA) room. Ionising radiation and chronic joint damage are still unavoidable for angiographers. Therefore, we researched and developed a neurointerventional robot-assisted system, which is operated by angiographers in an operating room outside the DSA room. We have
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Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry) Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-23 Angel Miraclin T, John Davis Prasad, George Abraham Ninan, Mahasampath Gowri, Deepti Bal, Atif Iqbal Ahmed Shaikh, Rohit N Benjamin, Appaswamy Thirumal Prabhakar, Ajith Sivadasan, Vivek Mathew, Sanjith Aaron
Background Multiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report the changes in the epidemiology of patients with CVT managed over the past 26 years. Methods The CMC Vellore CVT registry is a prospectively maintained database
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COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): a pilot study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-23 Jürgen Bardutzky, Rainer Kollmar, Forat Al-Rawi, Johann Lambeck, Mohammad Fazel, Christian Taschner, Wolf-Dirk Niesen
Background To evaluate the feasibility and safety of a fast initiation of cooling to a target temperature of 35°C by means of transnasal cooling in patients with anterior circulation large vessel occlusion (LVO) undergoing endovascular thrombectomy (EVT). Methods Patients with an LVO onset of <24 hour who had an indication for EVT were included in the study. Transnasal cooling (RhinoChill) was initiated
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Model based on single-nucleotide polymorphism to discriminate aspirin resistance patients Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-16 Qingyuan Liu, Shuaiwei Guo, Nuochuan Wang, Kaiwen Wang, Shaohua Mo, Xiong Li, Yanan Zhang, Hongwei He, Shuo Wang, Jun Wu
Background Aspirin is widely used for preventing ischaemic events. About 20%–40% of patients have aspirin resistance (ASR), which prevents them from benefiting from aspirin medication. This study aimed to develop and validate a model based on single-nucleotide polymorphism (SNP) to distinguish ASR patients. Methods We included patients with spontaneous intracerebral haemorrhage and continuing antiplatelet
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Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation: a multi-institutional, retrospective study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-16 Chloe Dumot, Georgios Mantziaris, Sam Dayawansa, Zhiyuan Xu, Stylianos Pikis, Selcuk Peker, Yavuz Samanci, Gokce D Ardor, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, Amr M N El-Shehaby, Reem M Emad Eldin, Ahmed H Elazzazi, Nuria Martínez Moreno, Roberto Martínez Álvarez, Roman Liscak, Jaromir May, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Akshay Rajput, Narendra Kumar
Background Cerebral cavernous malformations (CCMs) frequently manifest with haemorrhages. Stereotactic radiosurgery (SRS) has been employed for CCM not suitable for resection. Its effect on reducing haemorrhage risk is still controversial. The aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic CCM. Methods This retrospective multicentric study included CCM with at least
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Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Zhongyu Luo, Ying Zhou, Yaode He, Shenqiang Yan, Zhicai Chen, Xuting Zhang, Yi Chen, Lu-Sha Tong, Wansi Zhong, Haitao Hu, Kemeng Zhang, Jiansheng Yang, Bruce C V Campbell, Min Lou
Background While intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke (AIS) within 4.5 hours of symptom onset, there are few randomised trials investigating the benefits of thrombolysis beyond this therapeutic window. Aim To determine whether patients who had an AIS selected with the presence of potentially salvageable tissue on CT perfusion at 4.5–24 hours after stroke
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Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Guangyu Guo, Jingfei Yang, Wenliang Guo, Hong Deng, Haihan Yu, Shuang Bai, Gaigai Li, Yingxin Tang, Ping Zhang, Yuming Xu, Chao Pan, Zhouping Tang
Hyperhomocysteinemia (HHcy) is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage (ICH); however, the effect and mechanisms of HHcy on ICH are still unclear. Here, we evaluated neurite outgrowth and neurological functional recovery using simulated models of ICH with HHcy in vitro and in vivo. We found that the neurite outgrowth velocity and motor functional
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Correction: Indobufen versus aspirin in acute ischaemic stroke (INSURE): rationale and design of a multicentre randomised trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 BMJ Publishing Group Ltd
Pan Y, Meng X, Chen W, et al . Indobufen versus aspirin in acute ischaemic stroke (INSURE): rationale and design of a multicentre randomised trial. Stroke Vasc Neurol 2022;7:doi: 10.1136/svn-2021-001480 …
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Antithrombotic therapy in patients with COVID-19: indications, pharmacotherapy and controversy Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 David Wang, Christopher Leo, Liping Liu, Li Huang, Lisa Huang, Yun Lu
Hypercoagulability associated with COVID-19 infection increases risks for either venous or arterial thrombotic events (ATEs) or both.1 For hospitalised patients with COVID-19, the incidence of venous thromboembolism (VTE) was 4.5%2; the rate among patients with critical illness was 27.9% as compared with those not critically ill (7.1%). The exact mechanism of COVID-19-related thrombotic events is unclear
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Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Yangyang Zhou, Wenqiang Li, Chao Wang, Ruhang Xie, Yongnan Zhu, Qichen Peng, Limin Zhang, Hongqi Zhang, Yuxiang Gu, Shiqing Mu, Jian Liu, Xinjian Yang
Background and purpose Light transmission aggregometry (LTA) and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial aneurysms. The aim of this study was to determine which test can predict ischaemic events during these treatments. Methods Patient demographic information, imaging data, laboratory data and
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Mechanical thrombectomy with combined stent retriever and contact aspiration versus stent retriever alone for acute large vessel occlusion: data from ANGEL-ACT registry Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Xiaochuan Huo, Dapeng Sun, Mingkai Hu, Raynald, Baixue Jia, Xu Tong, Gaoting Ma, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Zhongrong Miao
Background and purpose An analysis of the ASTER 2 trial revealed similar final recanalisation levels and clinical outcomes in acute large vessel occlusion (LVO) stroke between stent retrieval (SR) alone as a first-line mechanical thrombectomy (MT) technique (SR alone first-line) and concomitant use of contact aspiration (CA) plus SR as a first-line MT technique (SR+CA first-line). The purpose of the
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Acute right insular ischaemic lesions and poststroke left ventricular dysfunction Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Klemens Winder, Carolina Villegas Millar, Gabriela Siedler, Michael Knott, Arnd Dörfler, Anna Engel, Stephan Achenbach, Max J Hilz, Bernd Kallmünzer, Stefan Schwab, Frank Seifert, Kilian Fröhlich
Introduction Myocardial injury related to acute ischaemic stroke is common even without primary cardiac disease. We intended to determine associations between values of left ventricular ejection fraction (LVEF) and ischaemic stroke lesion sites. Methods Of a local database, patients with acute first-ever ischaemic stroke confirmed by brain imaging but without pre-existing heart disease were included
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Angioarchitecture and prognosis of pediatric intracranial pial arteriovenous fistula Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Jingwei Li, Zhenlong Ji, Jiaxing Yu, Jian Ren, Fan Yang, Lisong Bian, Xinglong Zhi, Guilin Li, Hongqi Zhang
Objective Pial arteriovenous fistulas (PAVFs) are rare and mostly observed in children. However, the overall angioarchitecture, clinical features, treatments and long-term prognosis for pediatric patients remain unclear. Methods Clinical data of consecutive 42 pediatric PAVFs were documented and analysed. According to the differences of age distribution and clinical features, they were split into a
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Haemorrhage risk of brain arteriovenous malformation during pregnancy and puerperium Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Junyu Liu, Honghao Zhang, Chun Luo, Yuxin Guo, Yifeng Li, Dun Yuan, Weixi Jiang, Junxia Yan
Background This study aimed to assess whether pregnancy and puerperium were associated with the risk of brain arteriovenous malformation (bAVM) haemorrhage. Methods A retrospective review was conducted in Xiangya Hospital, Central South University from January 2012 to December 2021. A case–crossover design was adopted to calculate the incidence density of bAVM-related haemorrhage among female patients
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Differences in left and right carotid plaque vulnerability in patients with bilateral carotid plaques: a CARE-II study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Sai Shao, Honglu Shi, Guangbin Wang, Rui Li, Qinjian Sun, Bin Yao, Hiroko Watase, Daniel S Hippe, Chun Yuan, Xihai Zhao
Background and purpose Atherosclerosis is a very complex process influenced by various systemic and local factors. Therefore, in patients with bilateral carotid plaques (BCPs), there may be differences in carotid plaque vulnerability between the sides. We aimed to investigate the differences in BCP characteristics in patients with BCPs using magnetic resonance vessel wall imaging (MR-VWI). Methods
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Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Yuan Cao, Mei-Ying Huang, Chen-Hui Mao, Xue Wang, Yuan-Yuan Xu, Xiao-Jing Qian, Chao Ma, Wen-Ying Qiu, Yi-Cheng Zhu
Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains; however, its vascular aetiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenised venules has not been clarified. Here, we aimed to investigate the associations between microvascular injuries, including arteriolosclerosis and venular
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Association between statin therapy and the risk of stroke in patients with moyamoya disease: a nationwide cohort study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-08-01 Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim
Background and objective Knowledge regarding the pharmacological treatment for moyamoya disease (MMD), a chronic and progressive cerebrovascular disease conferring greater stroke risk, is limited. In the present study, whether statin therapy is associated with a reduced risk of stroke in patients with MMD was investigated. Methods This was a retrospective cohort study in which the occurrence of stroke
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A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-28 Zhuohua Wen, Xin Feng, Xin Tong, Chao Peng, Anqi Xu, Haiyan Fan, Yiming Bi, Wenchao Liu, Zhenjun Li, Shenquan Guo, Fa Jin, Ran Li, Yanchao Liu, Shixing Su, Xin Zhang, Xifeng Li, Xuying He, Aihua Liu, Chuanzhi Duan
Background and purpose Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs is unknown. We leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA formation. Methods We performed a two-sample Mendelian randomisation (MR) using publicly
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Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-26 Wei Li, Hao Li, Chaoxia Lu, Jialu Zhao, Huichun Xu, Zhe Xu, Braxton Mitchell, Yong Jiang, Hong-Qiu Gu, Qin Xu, Anxin Wang, Xia Meng, Jinxi Lin, Jing Jing, Zixiao Li, Wanlin Zhu, Zhigang Liang, Mengxing Wang, Yongjun Wang
Background and purpose Multiple factors play important roles in the occurrence and prognosis of stroke. However, the roles of monogenic variants in all-cause ischaemic stroke have not been systematically investigated. We aim to identify underdiagnosed monogenic stroke in an adult ischaemic stroke/transient ischaemic attack (TIA) cohort (the Third China National Stroke Registry, CNSR-III). Methods Targeted
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Randomised study of bailout intracranial angioplasty following thrombectomy for acute large vessel occlusion (ANGEL-REBOOT): protocol of a multicentre randomised controlled trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-19 Feng Gao, Xu Tong, Baixue Jia, Ming Yang, Yuesong Pan, Zeguang Ren, William Scott Burgin, Liping Liu, Xingquan Zhao, Yilong Wang, Yongjun Wang, Zhongrong Miao
Rationale Unsuccessful thrombectomy of acute large vessel occlusions (LVOs) has been associated with unfavourable outcomes. Multiple randomised controlled trials (RCTs) have reported a failure rate of 12%–41% for thrombectomy procedures. Various factors contribute to failed thrombectomy, including technical difficulties in accessing the occlusion, unsuccessful thrombus retrieval, thrombotic reocclusion
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Dural sinus septum: an underlying cause of cerebral venous sinus stenting failure and complications Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-11 Yangang Zhao, Xiaolan Zhang, Bin Lv, Jun Wang, Xinfeng Liu, Zhihua Du, Fang Cui, Baoming Li, Xing Chen, Xiangyu Cao
Objectives The presence of dural sinus septum has long been identified anatomically but is often neglected for its clinical significance. Our findings revealed the association of dural sinus septum with venous sinus stenting failure and complications supported by clinical evidence. Methods This retrospective study included 185 consecutive patients treated with cerebral venous sinus stenting from January
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Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-10 Romain Didier, Lucie Garnier, Gauthier Duloquin, Alexandre Meloux, Audrey Sagnard, Mathilde Graber, Geoffrey Dogon, Karim Benali, Thibaut Pommier, Gabriel Laurent, Catherine Vergely, Yannick Bejot, Charles Guenancia
Background Atrial cardiomyopathy (AC) is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation (AF). A definition based on the presence of electrical abnormality (P-wave terminal force in lead V1 (PTFV1) >5000 µV×ms), N-Terminal pro-B-type natriuretic peptide (NT pro BNP) >250 pg/mL and/or indexed left atrial diameter (LADI) >3 cm/m² is currently
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STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-07-03 Wenyu Li, Nan Shen, Lingqi Kong, Hongmei Huang, Xinyue Wang, Yan Zhang, Guoping Wang, Pengfei Xu, Wei Hu
Background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic stroke. Gasdermin D (GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death, which can exacerbate neuroinflammatory responses and brain damage. Stimulator of interferon genes (STING) was recently described as a vital innate immune adaptor protein associated with
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Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke: results of the prospective HEBRAS study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-06-23 Simon Hellwig, Thomas Krause, Jan F Scheitz, Juliane Herm, Ulrike Grittner, Nadja Jauert, Jochen B Fiebach, Mario Kasner, Wolfram Doehner, Matthias Endres, Rolf Wachter, Thomas Elgeti, Christian H Nolte, Karl Georg Haeusler
Background Stroke aetiology remains cryptogenic in a relevant proportion of patients with acute ischaemic stroke (AIS). We assessed whether enhanced diagnostic workup after AIS yields a higher rate of prespecified pathological findings compared with routine diagnostic care in-hospital. Methods Hospitalised patients with AIS were prospectively enrolled in the investigator-initiated observational HEart
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Implications of MMP-12 in the pathophysiology of ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-06-19 Krishna Kumar Veeravalli
This article focuses on the emerging role of matrix metalloproteinase-12 (MMP-12) in ischaemic stroke (IS). MMP-12 expression in the brain increases dramatically in animal models of IS, and its suppression reduces brain damage and promotes neurological, sensorimotor and cognitive functional outcomes. Thus, MMP-12 could represent a potential target for the management of IS. This article provides an
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Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-06-16 Yanfang Liu, Tianyuan Zhang, Xing Zou, Zhongwen Yuan, Yufeng Li, Jiankun Zang, Niu He, Lizhen He, Anding Xu, Dan Lu
Background Nanoparticles (NPs) are a class of substances that can be loaded with therapeutic agents delivered to specific areas. In our earlier research, we identified a neuron-derived circular RNA (circRNA), circular oxoglutarate dehydrogenase (CircOGDH), as a promising therapeutic target for acute ischaemic stroke. This study dedicated to explore a prospective preliminary strategy of CircOGDH-based
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Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-06-13 Miao Lin, Liubing Hu, Si Shen, Jiyue Liu, Yanyan Liu, Yixian Xu, Honglin Chen, Kazuo Sugimoto, Jianshuang Li, Ikuo Kamitsukasa, Takaki Hiwasa, Hao Wang, Anding Xu
Background Atherosclerosis (AS) and tumours are the leading causes of death worldwide and share common risk factors, detection methods and molecular markers. Therefore, searching for serum markers shared by AS and tumours is beneficial to the early diagnosis of patients. Methods The sera of 23 patients with AS-related transient ischaemic attack were screened by serological identification of antigens
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Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-06-13 ZeFeng Tan, Lei Zhang, Li'an Huang, Hongyu Qiao, Min Guan, Bing Yang, Pengfei Yang, Yongwei Zhang, Hongjian Shen, Yu Zhou, Bo Hong, Huaizhang Shi, Hongxing Han, Xinyi Leng, Yi Dong, Changlin Lian, Wenhuo Chen, Anding Xu, Jianmin Liu
Objective The impact of thrombus migration (TM) prior to endovascular thrombectomy (EVT) on clinical outcomes and revascularisation rates remains unknown. We aimed to examine whether preinterventional TM modifies the treatment effects of direct EVT versus bridging EVT in acute large vessel occlusion patients. Methods All patients undergoing catheter angiography in the Direct Intra-arterial thrombectomy