-
Treating Hypertension: Important for Heart Health, Fundamental for Brain Health Stroke (IF 8.3) Pub Date : 2024-03-15 Sanjula D. Singh, Jasper R. Senff, Cornelia M. van Duijn, Jonathan Rosand
The Brain Health crisis stands as one of humankind’s most pressing threats, with age-related noncommunicable brain diseases, particularly stroke, and dementia, affecting hundreds of millions annually and jeopardizing the economic well-being of populations worldwide. Epidemiological studies indicate that ≈40% of dementia and 60% of stroke cases are attributable to modifiable risk factors. In this Comments
-
Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study Stroke (IF 8.3) Pub Date : 2024-03-15 Jasper R. Senff, Sanjula D. Singh, Marco Pasi, Wilmar M.T. Jolink, Mark A. Rodrigues, Floris H.B.M. Schreuder, Julie Staals, Tobien Schreuder, Jules P.J. Douwes, Jelmer Talsma, Brenna N. McKaig, Christina Kourkoulis, Nirupama Yechoor, Christopher D. Anderson, Laurent Puy, Charlotte Cordonnier, Marieke J.H. Wermer, Peter M. Rothwell, Jonathan Rosand, Catharina J.M. Klijn, Rustam Al-Shahi Salman, Gabriël
BACKGROUND:Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on the long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess the long-term case fatality and recurrence rate of vascular events after a first cerebellar ICH.METHODS:In this international cohort study, we included patients from 10 hospitals (the
-
Moving From CT to MRI Paradigm in Acute Ischemic Stroke: Feasibility, Effects on Stroke Diagnosis and Long-Term Outcomes Stroke (IF 8.3) Pub Date : 2024-03-15 Costanza Maria Rapillo, Vincent Dunet, Silvia Pistocchi, Alexander Salerno, Vincent Darioli, Bruno Bartolini, Steven David Hajdu, Patrik Michel, Davide Strambo
BACKGROUND:The relative value of computed tomography (CT) and magnetic resonance imaging (MRI) in acute ischemic stroke (AIS) is debated. In May 2018, our center transitioned from using CT to MRI as first-line imaging for AIS. This retrospective study aims to assess the effects of this paradigm change on diagnosis and disability outcomes.METHODS:We compared all consecutive patients with confirmed diagnosis
-
Association of Posttraumatic Stress Disorder and Race on Readmissions After Stroke Stroke (IF 8.3) Pub Date : 2024-03-14 Chen Lin, Peter H. King, Joshua S. Richman, Lori L. Davis
BACKGROUND:There is limited research on outcomes of patients with posttraumatic stress disorder (PTSD) who also develop stroke, particularly regarding racial disparities. Our goal was to determine whether PTSD is associated with the risk of hospital readmission after stroke and whether racial disparities existed.METHODS:The analytical sample consisted of all veterans receiving care in the Veterans
-
CTP-Defined Large Core Is a Better Predictor of Poor Outcome for Endovascular Treatment Than ASPECTS-Defined Large Core Stroke (IF 8.3) Pub Date : 2024-03-15 Yi Sui, Wenhuo Chen, Chushuang Chen, Yanting Chang, Andrew Bivard, Peng Wang, Yu Geng, Mark Parsons, Longting Lin, on behalf of INSPIRE Investigators
BACKGROUND:Recent trials confirmed the effectiveness of endovascular therapy in patients with large ischemic cores. Yet the optimal neuroimaging modalities to define large core remains unclear. We tried to address this question by comparing the functional outcomes in patients receiving thrombectomy selected by either noncontrast computed tomography Alberta Stroke Program Early Computed Tomography Score
-
Health Inequity and Time From Pediatric Stroke Onset to Arrival Stroke (IF 8.3) Pub Date : 2024-03-15 Akshat M. Pai, Teresa To, Gabrielle A. deVeber, Daniel Nichol, Andrea Kassner, Birgit Ertl-Wagner, Mubeen F. Rafay, Nomazulu Dlamini
BACKGROUND:Time from stroke onset to hospital arrival determines treatment and impacts outcome. Structural, socioeconomic, and environmental factors are associated with health inequity and onset-to-arrival in adult stroke. We aimed to assess the association between health inequity and onset-to-arrival in a pediatric comprehensive stroke center.METHODS:A retrospective observational study was conducted
-
Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease Stroke (IF 8.3) Pub Date : 2024-03-11 Hui Hong, Daniel J. Tozer, Hugh S. Markus
BACKGROUND:Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia.METHODS:In patients
-
Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis Stroke (IF 8.3) Pub Date : 2024-03-11 Yang Zhang, Tian Lv, Thanh N. Nguyen, Simiao Wu, Zhi Li, Xue Bai, Dan Chen, Chuansheng Zhao, Wanyi Lin, Shiqin Chen, Yi Sui
Background:The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. The aim of this study is to compare the effectiveness and safety of IVT with best medical therapy (BMT) by means of a systematic review and meta-analysis of randomized controlled trials and observational studies.Methods:We searched the PubMed, Embase, Cochrane
-
Plasma Metabolites and Life’s Simple 7 in REGARDS Stroke (IF 8.3) Pub Date : 2024-03-14 Naruchorn Kijpaisalratana, Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Alana C. Jones, Catharine A. Couch, Ana-Lucia Garcia Guarniz, Mary Cushman, D. Leann Long, Suzanne E. Judd, M. Ryan Irvin, W. Taylor Kimberly
BACKGROUND:The American Heart Association’s Life’s Simple 7 (LS7) is a health metric that captures important factors associated with cardiovascular and cerebrovascular health. Previous studies highlight the potential of plasma metabolites to serve as a marker for lifestyle and health behavior that could be a target for stroke prevention. The objectives of this study were to identify metabolites that
-
Heterogeneity of State Stroke Center Certification and Designation Processes Stroke (IF 8.3) Pub Date : 2024-03-12 Madeline Feldmeier, Anthony S. Kim, Kori S. Zachrison, Mark J. Alberts, Yu-Chu Shen, Renee Y. Hsia
BACKGROUND:Stroke centers are critical for the timely diagnosis and treatment of acute stroke and have been associated with improved treatment and outcomes; however, variability exists in the definitions and processes used to certify and designate these centers. Our study categorizes state stroke center certification and designation processes and provides examples of state processes across the United
-
Neutrophil Extracellular Traps and Thrombolysis Resistance: New Insights for Targeting Therapies Stroke (IF 8.3) Pub Date : 2024-03-11 Luca Mengozzi, Ilaria Barison, Martin Malý, Giulia Lorenzoni, Marny Fedrigo, Chiara Castellani, Dario Gregori, Petr Malý, Radoslav Matěj, Petr Toušek, Petr Widimský, Annalisa Angelini
BACKGROUND:Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi retrieved after mechanical thrombectomy, estimate the age and organization of thrombi, and evaluate associations with the use of thrombolysis, antiplatelets, and heparin.METHODS:This retrospective
-
Cardiovascular Management in Asymptomatic (Silent) Cerebral Microbleeds and Suspected Cerebral Amyloid Angiopathy Stroke (IF 8.3) Pub Date : 2024-03-11 Andreas Charidimou, Eric E. Smith
Cerebral microbleeds (CMBs) detected on blood-sensitive magnetic resonance imaging sequences are usually a sign of an underlying cerebral small vessel disease such as sporadic cerebral amyloid angiopathy or sporadic nonamyloid small vessel pathology (eg, arteriolosclerosis). Much of the enduring interest in CMBs relates to their high prevalence (partly due to the widespread use of magnetic resonance
-
Thrombolysis for Wake-Up Stroke Versus Non–Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis Stroke (IF 8.3) Pub Date : 2024-03-08 Naruhiko Kamogawa, Kaori Miwa, Kazunori Toyoda, Märit Jensen, Manabu Inoue, Sohei Yoshimura, Mayumi Fukuda-Doi, Takanari Kitazono, Florent Boutitie, Henry Ma, Peter Ringleb, Ona Wu, Lee H. Schwamm, Steven Warach, Werner Hacke, Stephen M. Davis, Geoffrey A. Donnan, Christian Gerloff, Götz Thomalla, Masatoshi Koga
Background:Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non–wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups.Methods:Patients with an unknown-onset stroke were
-
What Do We Really Know About the Effect of Prolonged Heart Rhythm Monitoring After Stroke? Stroke (IF 8.3) Pub Date : 2024-03-08 Håkon Ihle-Hansen, Guri Hagberg, Hege Ihle-Hansen, Else Chartlotte Sandset, Jason G. Andrade, John Mandrola, Søren Zöga Diederichsen
The bulk of the current knowledge on atrial fibrillation (AF)-associated stroke risk and benefit of oral anticoagulation derives from studies on patients with clinically diagnosed AF. Subclinical AF (SCAF), defined as AF discovered during the interrogation of prolonged heart monitoring, is often asymptomatic and short-lasting, is associated with increased stroke risk compared with sinus rhythm, and
-
Inhibition of Anaplastic Lymphoma Kinase Protects From Ischemic Stroke Stroke (IF 8.3) Pub Date : 2024-03-06 Yue Hu, Luping Chang, Yuanbo Zhu, Xue Geng, Zhongwang Liu, Ranran Wang, Yiheng Wang, Bing-Qiao Zhao, Wenying Fan
BACKGROUND:Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption of the blood-brain barrier and ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found to play a role in oxidative stress and inflammation. In this study, we investigated the role of ALK
-
Imaging Biomarkers of VCI: A Focused Update Stroke (IF 8.3) Pub Date : 2024-03-06 Una Clancy, Angelina K. Kancheva, Maria del C. Valdés Hernández, Angela C.C. Jochems, Susana Muñoz Maniega, Terence J. Quinn, Joanna M. Wardlaw
Vascular cognitive impairment is common after stroke, in memory clinics, medicine for the elderly services, and undiagnosed in the community. Vascular disease is said to be the second most common cause of dementia after Alzheimer disease, yet vascular dysfunction is now known to predate cognitive decline in Alzheimer disease, and most dementias at older ages are mixed. Neuroimaging has a major role
-
Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: A Comparative Cohort Study Stroke (IF 8.3) Pub Date : 2024-03-06 Nedelina Slavova, Robin Muenger, Iciar Sanchez-Albisua, Maria Regényi, Gabriela Oesch, Joël Fluss, Annette Hackenberg, Sébastien Lebon, Oliver Maier, Alexandre N. Datta, Sandra Bigi, Sebastian Grunt, Maja Steinlin
BACKGROUND:Inflammatory type focal cerebral arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized, and the focal cerebral arteriopathy severity score (FCASS) reflects the severity of the disease. We identified cases of FCA-i in the posterior circulation (PC) and adapted the FCASS to describe these cases.METHODS:In this comparative cohort study, patients from the Swiss NeuroPaediatric
-
Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy Stroke (IF 8.3) Pub Date : 2024-03-06 Emma A. Koemans, Ingeborg Rasing, Sabine Voigt, Thijs W. van Harten, Reinier G.J. van der Zwet, Kanishk Kaushik, Manon R. Schipper, Nelleke van der Weerd, Erik W. van Zwet, Ellis S. van Etten, Matthias J.P. van Osch, Bea Kuiperij, Marcel M. Verbeek, Gisela M. Terwindt, Steven M. Greenberg, Marianne A.A. van Walderveen, Marieke J.H. Wermer
BACKGROUND:The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important for their use in trials and for the understanding of the pathological cascade of CAA. We investigated the presence and abnormality of the most common biomarkers in the largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date.METHODS:We included cross-sectional data from participants with
-
What Is a Meaningful Difference When Using Infarct Volume as the Primary Outcome?: Results From the HERMES Database Stroke (IF 8.3) Pub Date : 2024-03-05 Leon A. Rinkel, Johanna M. Ospel, Scott B. Brown, Bruce C.V. Campbell, Diederik W.J. Dippel, Andrew M. Demchuk, Charles B.L.M. Majoie, Peter J. Mitchell, Serge Bracard, Francis Guillemin, Tudor G. Jovin, Keith W. Muir, Philip White, Jeffrey L. Saver, Michael D. Hill, Mayank Goyal, on behalf of the HERMES Collaborators
BACKGROUND:Ischemic stroke lesion volume at follow-up is an important surrogate outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion volume translate into meaningful clinical differences.METHODS:We used pooled data from 7 trials investigating the efficacy of endovascular treatment for anterior circulation large vessel occlusion in acute ischemic stroke. We assessed
-
Climate Change and Stroke: A Topical Narrative Review Stroke (IF 8.3) Pub Date : 2024-03-04 Anna Ranta, Janice Kang, Ali Saad, Mohammed Wasay, Yannick Béjot, Serefnur Ozturk, Maurice Giroud, Jacques Reis, Jeroen Douwes
The impacts of accumulating atmospheric greenhouse gases on the earth’s climate are now well established. As a result, there have been increases in ambient temperatures and resultant higher frequency and duration of temperature extremes and other extreme weather events, which have been linked to a wide range of adverse health outcomes. This topical narrative review provides a summary of published evidence
-
Design of a Stem Cell–Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages Stroke (IF 8.3) Pub Date : 2024-03-04 Luis M. Rodriguez-Perez, Betsaida Ojeda-Pérez, Javier López-de-San-Sebastián, María García-Bonilla, Marcos González-García, Beatriz Fernández-Muñoz, Rosario Sánchez-Pernaute, María L. García-Martín, Dolores Domínguez-Pinos, Casimiro Cárdenas-García, Antonio J. Jiménez, Patricia Paez-Gonzalez
BACKGROUND:In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors (EpPs), and mesenchymal stem cells.METHODS:GMH/PHH was induced in 4-day-old mice using
-
Higher Frequency of Premature Atrial Contractions Correlates With Atrial Fibrillation Detection after Cryptogenic Stroke Stroke (IF 8.3) Pub Date : 2024-03-04 Yuki Shimada, Kenichi Todo, Ryosuke Doijiri, Hidekazu Yamazaki, Kazutaka Sonoda, Junpei Koge, Tomonori Iwata, Yuji Ueno, Hiroshi Yamagami, Naoto Kimura, Masafumi Morimoto, Daisuke Kondo, Masatoshi Koga, Eiichiro Nagata, Nobukazu Miyamoto, Yoko Kimura, Yasufumi Gon, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
Background:Covert atrial fibrillation (AF) is a major cause of cryptogenic stroke. This study investigated whether a dose-dependent relationship exists between the frequency of premature atrial contractions (PACs) and AF detection in patients with cryptogenic stroke using an insertable cardiac monitor (ICM).Methods:We enrolled consecutive patients with cryptogenic stroke who underwent ICM implantation
-
Influence of Time to Achieve Target Systolic Blood Pressure on Outcome After Intracerebral Hemorrhage: The Blood Pressure in Acute Stroke Collaboration Stroke (IF 8.3) Pub Date : 2024-02-27 Xia Wang, Jie Yang, Tom J. Moullaali, Else Charlotte Sandset, Lisa J. Woodhouse, Zhe Kang Law, Hisatomi Arima, Kenneth S. Butcher, Candice Delcourt, Leon Edwards, Salil Gupta, Wen Jiang, Sebastian Koch, John Potter, Adnan I. Qureshi, Thompson G. Robinson, Rustam Al-Shahi Salman, Jeffrey L. Saver, Nikola Sprigg, Joanna Wardlaw, Craig S. Anderson, Yuki Sakamoto, Philip M. Bath, John Chalmers, The Blood
OBJECTIVE:To investigate whether an earlier time to achieving and maintaining systolic blood pressure (SBP) at 120 to 140 mm Hg is associated with favorable outcomes in a cohort of patients with acute intracerebral hemorrhage.METHODS:We pooled individual patient data from randomized controlled trials registered in the Blood Pressure in Acute Stroke Collaboration. Time was defined as time form symptom
-
Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise Stroke (IF 8.3) Pub Date : 2024-02-27 Elizabeth Dao, Cindy K. Barha, Jammy Zou, Nathan Wei, Teresa Liu-Ambrose
Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Exercise has the potential to prevent and mitigate CSVD-related brain damage and improve cognitive function
-
Correction to: Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies Stroke (IF 8.3) Pub Date : 2024-02-26
In the article by O’Keefe et al, “Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies,” which published online on December 22, 2023, and appeared in the January 2024 issue of the journal (Stroke. 2024;55:50–58. doi: 10.1161/STROKEAHA.123.044281), a correction is needed. On page 56, the affiliation for Jayanta K. Das is incorrect
-
Dose Response to Upper Extremity Stroke Rehabilitation Varies by Individual: Early Indicators of Treatment Response Stroke (IF 8.3) Pub Date : 2024-02-26 Lynne V. Gauthier, Roshan Ravi, David DeLuca, Wenjin Zhou
BACKGROUND:Dose response has remained a priority area in motor rehabilitation research for decades, prompting several large randomized trials and meta-analyses. These between-subjects comparisons have revealed equivocal relationships between the duration of motor practice and rehabilitation response. Prior reliance on time-consuming clinical assessments made it infeasible to capture within-subjects
-
Reversible Cerebral Vasoconstriction Syndrome and Female Sex: A Narrative Review Stroke (IF 8.3) Pub Date : 2024-02-16 Sarah E. Nelson
Reversible cerebral vasoconstriction syndrome (RCVS) refers to segmental, multifocal constriction of intracranial arteries along with acute headache and resolves within weeks. It occurs more commonly in women, and 1 well-known manifestation of RCVS is postpartum angiopathy. Furthermore, the female sex is included in scoring systems designed to assist with diagnosing RCVS. Nonetheless, the literature
-
Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials Stroke (IF 8.3) Pub Date : 2024-02-16 Hongfei Sang, Zhihua Cao, Jie Du, Thanh N. Nguyen, Jeffrey L. Saver, An Mao, Raul G. Nogueira, Zhaojun Tao, Simin Zhou, Qin Han, Dong Sun, Bo Lei, Shudong Liu, Guoyong Zeng, Congguo Yin, Dongjing Xie, Weidong Luo, Zhenglong Jin, Zhongming Qiu
BACKGROUND:The present study aimed to evaluate the efficacy and safety of intravenous tirofiban versus alteplase before endovascular treatment (EVT) in acute ischemic stroke patients with intracranial large vessel occlusion.METHODS:This was a post hoc analysis using data from 2 multicenter, randomized trials: the DEVT trial (Direct Endovascular Treatment for Large Vessel Occlusion Stroke) from May
-
Cortical Spreading Depolarization in Moyamoya Vasculopathy: A Case Series Stroke (IF 8.3) Pub Date : 2024-02-16 Patrick Dömer, Simeon O.A. Helgers, Franziska Meinert, Renán Sánchez-Porras, Christian Mathys, Karsten Witt, Peter Vajkoczy, Nils Hecht, Johannes Woitzik
Background:Spreading depolarization describes a near-complete electrical discharge with altered local cerebral blood flow. It is described in association with acute and chronic diseases like hemorrhagic stroke or migraine. Moyamoya vasculopathy is a chronic, progressive cerebrovascular disorder leading to cerebral hypoperfusion, hemodynamically insufficient basal collateralization, and increased cortical
-
Association of HIV and HCV Infection With Carotid Artery Plaque Echomorphology in the MACS/WIHS Combined Cohort Study Stroke (IF 8.3) Pub Date : 2024-02-09 Claudio A. Bravo, Jee-Young Moon, Krista Davy, Robert C. Kaplan, Kathryn Anastos, Carlos J. Rodriguez, Wendy S. Post, Stephen J. Gange, Seble G. Kassaye, Lawrence A. Kingsley, Jason M. Lazar, Wendy J. Mack, Nataliya Pyslar, Phyllis C. Tien, Mallory D. Witt, Frank J. Palella, Yanjie Li, Mingzhu Yan, Howard N. Hodis, David B. Hanna
BACKGROUND:HIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. We examined associations of HIV- and HCV-related factors with echomorphologic features of carotid artery plaque.METHODS:This cross-sectional study included participants from the MACS (Multicenter AIDS Cohort Study)/WIHS (Women’s Interagency HIV Study) Combined Cohort Study
-
Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study Stroke (IF 8.3) Pub Date : 2024-02-09 Shadi Yaghi, Liqi Shu, Daniel M Mandel, Christopher R Leon Guerrero, Nils Henninger, Jayachandra Muppa, Muhammad Affan, Omair Ul Haq Lodhi, Mirjam R Heldner, Kateryna Antonenko, David J Seiffge, Marcel Arnold, Setareh Salehi Omran, Ross Curtiss Crandall, Evan Lester, Diego Lopez Mena, Antonio Arauz, Ahmad Nehme, Marion Boulanger, Emmanuel Touzé, João André Sousa, Joao Sargento-Freitas, Vasco Barata
Background: Small, randomized trials of cervical artery dissection (CAD) patients showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in patients with CAD treated with antiplatelets versus anticoagulation.Methods: This is a multi-center observational retrospective international study (16 countries, 63 sites) that included CAD patients without major
-
High-Intensity Aphasia Therapy Is Cost-Effective in People With Poststroke Aphasia: Evidence From the COMPARE Trial Stroke (IF 8.3) Pub Date : 2024-02-08 Joosup Kim, Miranda L. Rose, John E. Pierce, Lyndsey Nickels, David A. Copland, Leanne Togher, Erin Godecke, Marcus Meinzer, Tapan Rai, Melanie Hurley, Abby Foster, Marcella Carragher, Cassie Wilcox, Dominique A. Cadilhac
BACKGROUND:Evidence from systematic reviews confirms that speech and language interventions for people with aphasia during the chronic phase after stroke (>6 months) improve word retrieval, functional communication, and communication-related quality of life. However, there is limited evidence of their cost-effectiveness. We aimed to estimate the cost per quality-adjusted life year gained from 2 speech
-
Diastolic Dysfunction as a Positive Predictor of Recurrent Vascular Events in Patients With Noncardioembolic Stroke Stroke (IF 8.3) Pub Date : 2024-02-08 Kentaro Ishizuka, Takao Hoshino, Takafumi Mizuno, Shuntaro Takahashi, Sho Wako, Satoko Arai, Sono Toi, Kazuo Kitagawa
BACKGROUND:This study aimed to assess the effects of left ventricular diastolic dysfunction (LVDD) on vascular outcomes among patients with stroke of noncardioembolic origins.METHODS:This prospective observational study enrolled 563 patients with noncardioembolic stroke (mean age, 67.9 years; 66.7% men and 33.3% women individuals) registered in the Tokyo Women’s Medical University Stroke Registry between
-
Increased Risk of Recurrent Stroke in Symptomatic Large Vessel Disease With Impaired BOLD Cerebrovascular Reactivity Stroke (IF 8.3) Pub Date : 2024-02-08 Christiaan H.B. van Niftrik, Martina Sebök, Menno R. Germans, Matthias Halter, Thomas Pokorny, Vittorio Stumpo, Jacopo Bellomo, Marco Piccirelli, Athina Pangalu, Mira Katan, Susanne Wegener, Michael Tymianski, Zsolt Kulcsár, Andreas R. Luft, Joseph A. Fisher, David J. Mikulis, Luca Regli, Jorn Fierstra
BACKGROUND:Impaired cerebrovascular reactivity (CVR) has been correlated with recurrent ischemic stroke. However, for clinical purposes, most CVR techniques are rather complex, time-consuming, and lack validation for quantitative measurements. The recent adaptation of a standardized hypercapnic stimulus in combination with a blood-oxygenation-level-dependent (BOLD) magnetic resonance imaging signal
-
Secular Trends in Outcomes and Impact of Novel Oral Anticoagulants in Atrial Fibrillation–Related Acute Ischemic Stroke Stroke (IF 8.3) Pub Date : 2024-02-08 Minwoo Lee, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Beom Joon Kim, Jun Yup Kim, Jihoon Kang, Keon-Joo Lee, Do Yeon Kim, Jong-Moo Park, Kyusik Kang, Tai Hwan Park, Kyung Bok Lee, Keun-Sik Hong, Hong-Kyun Park, Yong-Jin Cho, Dong-Eog Kim, Soo Joo Lee, Jae Guk Kim, Jun Lee, Jae-Kwan Cha, Dae-Hyun Kim, Joon-Tae Kim, Kang-Ho Choi, Jay Chol Choi, Sung-il Sohn, Jeong-Ho Hong, Sang-hwa Lee, Chulho Kim, Dong-Ick
BACKGROUND:Novel oral anticoagulants (NOACs) are currently recommended for the secondary prevention of stroke in patients with acute ischemic stroke (AIS) accompanied by atrial fibrillation (AF). However, the impact of NOACs on clinical outcomes in real-world practice remains ambiguous. This study analyzes the trend of clinical events in patients with AF-related AIS and determines how much the introduction
-
Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients With Acute Ischemic Stroke Stroke (IF 8.3) Pub Date : 2024-02-07 Abderahim Gaceb, Linnea Roupé, Andreas Enström, Wejdan Almasoudi, Robert Carlsson, Arne G. Lindgren, Gesine Paul
BACKGROUND:Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo. In ischemic stroke, the progression of pathology involves changes in microvascular signaling
-
Albumin Levels and Risk of Early Cardiovascular Complications After Ischemic Stroke: A Propensity-Matched Analysis of a Global Federated Health Network Stroke (IF 8.3) Pub Date : 2024-02-07 Tommaso Bucci, Daniele Pastori, Pasquale Pignatelli, George Ntaios, Azmil H. Abdul-Rahim, Francesco Violi, Gregory Y.H. Lip
BACKGROUND:No studies have investigated the association between albumin levels and the risk of early cardiovascular complications in patients with ischemic stroke.METHODS:Retrospective analysis with a federated research network (TriNetX) based on electronic medical records (International Classification of Diseases-Tenth Revision-Clinical Modification and logical observation identifiers names and codes)
-
Comparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry Stroke (IF 8.3) Pub Date : 2024-02-05 Chih-Hao Chen, Chung-Wei Lee, Yi-Chen Hsieh, Chun-Jen Lin, Yu-Wei Chen, Kuan-Hung Lin, Pi-Shan Sung, Chih-Wei Tang, Hai-Jui Chu, Kun-Chang Tsai, Chao-Liang Chou, Ching-Huang Lin, Cheng-Yu Wei, Shang-Yih Yen, Po-Lin Chen, Hsu-Ling Yeh, Lung Chan, Sheng-Feng Sung, Meng Lee, Hon-Man Liu, Yen-Heng Lin, I-Hui Lee, Shin-Joe Yeh, Li-Ming Lien, Hung-Yi Chiou, Jiunn-Tay Lee, Sung-Chun Tang, Jiann-Shing Jeng
BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. Currently, it is unknown whether a low-dose thrombolytic agent (0.6 mg/kg alteplase) can offer similar efficacy to the standard dose (0.9 mg/kg alteplase).METHODS:We enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy
-
Radial Versus Femoral Access for Mechanical Thrombectomy in Stroke Patients: A Non-Inferiority Randomized Clinical Trial Stroke (IF 8.3) Pub Date : 2024-02-01 David Hernandez, Manuel Requena, Marta Olivé Gadea, Marta De Dios Lascuevas, Laura Ludovica Gramegna, Marian Muchada, Álvaro García-Tornel, Francesco Diana, Federica Rizzo, Eila Rivera, Marta Rubiera, Carlos Piñana, Marc Rodrigo-Gisbert, David Rodriguez-Luna, JORGE PAGOLA, Tomás Carmona, Jesus Juega, Noelia Rodriguez-Villatoro, Carlos A. Molina, Marc Ribo, Alejandro Tomasello
Background: Transfemoral access is predominantly used for mechanical thrombectomy in stroke patients with a large vessel occlusion. Following the interventional cardiology guidelines, routine transradial access has been proposed as an alternative, although its safety and efficacy remain controversial. We aim to explore the non-inferiority of radial access in terms of final recanalization.Methods: The
-
Diversity, Equity, and Inclusion Lessons From Developing Stroke Education Programs for West Michigan Asian Communities Stroke (IF 8.3) Pub Date : 2024-02-01 Aileen A. Antonio, Taylor Anderson, Vincent Ngo, Sojung Park, Susan Woolner, Muhammad Farooq, Ronel Santos, Philip Gorelick
BACKGROUND:Asians in the United States, facing health care disparities, have increased stroke risk. Multiple subgroups, with distinct cultures and languages, add complexity to caring for Asian American (AsA) communities. We developed a tailored stroke education program for underserved West Michigan AsA communities. Methodology, lessons learned, and diversity, equity, and inclusion insights are described
-
Microglial TLR4 Mediates White Matter Injury in a Combined Model of Diesel Exhaust Exposure and Cerebral Hypoperfusion Stroke (IF 8.3) Pub Date : 2024-02-01 Kristina Shkirkova, Alexandra N Demetriou, Saman Sizdahkhani, Krista Lamorie-Foote, Hongqiao Zhang, Manuel Morales, Selena Chen, Lifu Zhao, Arnold Diaz, Jose A Godoy-Lugo, Beryl Zhou, Nathan Zhang, Andrew Li, Wendy Mack, Constantinos Sioutas, Max A Thorwald, Caleb Finch, Christian J Pike, William Mack
Background: Air pollution particulate matter (PM) exposure and chronic cerebral hypoperfusion (CCH) contribute to white matter toxicity through shared mechanisms of neuroinflammation, oxidative stress, and myelin breakdown. Prior studies showed that exposure of mice to joint PM and CCH caused supra-additive injury to corpus callosum white matter. This study examines the role of toll-like receptor 4
-
Transcarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis Stroke (IF 8.3) Pub Date : 2024-02-01 Malik Ghannam, Mohammad AlMajali, Farid Khasiyev, Mahmoud Dibas, Abdullah Al Qudah, Fawaz AlMajali, Dana Ghazaleh, Asghar Shah, Fayez H. Fayad, Kareem Joudi, Bashar Zaidat, Christopher A. Childs, Bennett R. Levy, Yasmeen Abouainain, Denise M.D. Özdemir-van Brunschot, Liqi Shu, Eric D. Goldstein, Ammad A. Baig, Hannah Roeder, Nils Henninger, Adam de Havenon, Elad I. Levy, Charles Matouk, Colin P. Derdeyn
BACKGROUND:Transcarotid artery revascularization (TCAR) is an interventional therapy for symptomatic internal carotid artery disease. Currently, the utilization of TCAR is contentious due to limited evidence. In this study, we evaluate the safety and efficacy of TCAR in patients with symptomatic internal carotid artery disease compared with carotid endarterectomy (CEA) and carotid artery stenting (CAS)
-
Effect of Remote Ischemic Conditioning in Ischemic Stroke Subtypes: A Post Hoc Subgroup Analysis From the RESIST Trial Stroke (IF 8.3) Pub Date : 2024-02-01 Rolf Ankerlund Blauenfeldt, Janne Kaergaard Mortensen, Niels Hjort, Jan Brink Valentin, Anne-Mette Homburg, Boris Modrau, Birgitte Forsom Sandal, Martin Faurholdt Gude, Anne Brink Berhndtz, Søren Paaske Johnsen, David C. Hess, Claus Ziegler Simonsen, Grethe Andersen
BACKGROUND:Remote ischemic conditioning (RIC) is a simple and noninvasive procedure that has proved to be safe and feasible in numerous smaller clinical trials. Mixed results have been found in recent large randomized controlled trials. This is a post hoc subgroup analysis of the RESIST trial (Remote Ischemic Conditioning in Patients With Acute Stroke), investigating the effect of RIC in different
-
Association of Assisted Reproductive Technology and Stroke During Hospitalization for Delivery in the United States Stroke (IF 8.3) Pub Date : 2024-02-01 Alis J. Dicpinigaitis, Alison Seitz, Jill Berkin, Fawaz Al-Mufti, Hooman Kamel, Babak Benjamin Navi, Anokhi Pawar, Halina White, Ava L. Liberman
Background: Infertility treatment with assisted reproductive technologies (ART) has been associated with adverse vascular events in some, but not all previous studies. Endothelial damage, prothrombotic factor release, and a higher prevalence of cardiovascular risk factors in those receiving ART have been invoked to explain this association. We sought to explore the relationship between ART and stroke
-
Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association Stroke (IF 8.3) Pub Date : 2024-02-01 Shadi Yaghi, Stefan Engelter, Victor J. Del Brutto, Thalia S. Field, Ashutosh P. Jadhav, Kimberly Kicielinski, Tracy E. Madsen, Eva A. Mistry, Setareh Salehi Omran, Aditya Pandey, Eytan Raz, on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease
Cervical artery dissection is an important cause of stroke, particularly in young adults. Data conflict on the diagnostic evaluation and treatment of patients with suspected cervical artery dissection, leading to variability in practice. We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence
-
Epidemiology of Spontaneous Cervical Artery Dissection: Population-Based Study Stroke (IF 8.3) Pub Date : 2024-01-30 Kim J. Griffin, William S. Harmsen, Jay Mandrekar, Robert D. Brown Jr, Zafer Keser
BACKGROUND:Cervical artery dissection (CeAD) represents up to 15% to 25% of ischemic strokes in people under the age of 50 years. Noninvasive vessel imaging is increasingly used in clinical practice, but the impact on the frequency of detection of CeAD is unknown. In 2006, the yearly incidence rate of CeAD was estimated at 2.6 per 100 000 person-years, but the current incidence is unknown.METHODS:In
-
Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke Stroke (IF 8.3) Pub Date : 2024-01-30 Jonathane Furon, Florent Lebrun, Mervé Yétim, Damien Levard, Pauline Marie, Cyrille Orset, Sara Martinez de Lizarrondo, Denis Vivien, Carine Ali
BACKGROUND:Intravenous injection of alteplase, a recombinant tPA (tissue-type plasminogen activator) as a thrombolytic agent has revolutionized ischemic stroke management. However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier. Accordingly
-
Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association Stroke (IF 8.3) Pub Date : 2024-01-29 Gustavo Saposnik, Cheryl Bushnell, Jonathan M. Coutinho, Thalia S. Field, Karen L. Furie, Najibah Galadanci, Wayneho Kam, Fenella C. Kirkham, Norma D. McNair, Aneesh B. Singhal, Vincent Thijs, Victor X.D. Yang, on behalf of the American Heart Association Stroke Council, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Cardiovascular and Stroke Nursing, and Council
Cerebral venous thrombosis accounts for 0.5% to 3% of all strokes. The most vulnerable populations include young individuals, women of reproductive age, and patients with a prothrombotic state. The clinical presentation of cerebral venous thrombosis is diverse (eg, headaches, seizures), requiring a high level of clinical suspicion. Its diagnosis is based primarily on magnetic resonance imaging/magnetic
-
Dynamic Imaging of Blood Coagulation Within the Hematoma of Patients With Acute Hemorrhagic Stroke Stroke (IF 8.3) Pub Date : 2024-01-26 Muhammad E. Haque, Seth B. Boren, James Mills, Kerry G. Schneider, Maria Parekh, Stuart M. Fraser, Ivo Bach, Praveen Hariharan, Pamela J. Zelnick, Felix S. Guerra Castanon, Asim Naveed, Muhammad Tariq, Octavio D. Arevalo, Khader M. Hasan, Miguel Escobar, Xiurong Zhao, Clark Sitton, Ponnada A. Narayana, James C. Grotta, Jaroslaw Aronowski, Sean I. Savitz
BACKGROUND:The dynamics of blood clot (combination of Hb [hemoglobin], fibrin, and a higher concentration of aggregated red blood cells) formation within the hematoma of an intracerebral hemorrhage is not well understood. A quantitative neuroimaging method of localized coagulated blood volume/distribution within the hematoma might improve clinical decision-making.METHODS:The deoxyhemoglobin of aggregated
-
Impact of Comorbid Sleep-Disordered Breathing and Atrial Fibrillation on the Long-Term Outcome After Ischemic Stroke Stroke (IF 8.3) Pub Date : 2024-01-26 Xiaoli Yang, Julian Lippert, Martijn Dekkers, Sebastien Baillieul, Simone B. Duss, Tobias Reichlin, Anne-Kathrin Brill, Corrado Bernasconi, Markus H. Schmidt, Claudio L.A. Bassetti
BACKGROUND:Sleep-disordered breathing (SDB) and atrial fibrillation (AF) are highly prevalent in patients with stroke and are recognized as independent risk factors for stroke. Little is known about the impact of comorbid SDB and AF on long-term outcomes after stroke.METHODS:In this prospective cohort study, 353 patients with acute ischemic stroke or transient ischemic attacks were analyzed. Patients
-
Longitudinal Changes in Iron and Myelination Within Ischemic Lesions Associate With Neurological Outcomes: A Pilot Study Stroke (IF 8.3) Pub Date : 2024-01-25 Yuto Uchida, Hirohito Kan, Yuya Kano, Kengo Onda, Keita Sakurai, Koji Takada, Yoshino Ueki, Noriyuki Matsukawa, Argye E. Hillis, Kenichi Oishi
BACKGROUND:Combined quantitative susceptibility mapping and R2* relaxometry can distinguish iron and myelin components in ischemic lesions. We aimed to investigate whether longitudinal changes in magnetic susceptibility and R2* values within ischemic lesions were associated with neurological outcomes.METHODS:In this single-center prospective study, we included patients, 20 to 90 years of age, who were
-
Screening of Moyamoya Disease From Retinal Photographs: Development and Validation of Deep Learning Algorithms Stroke (IF 8.3) Pub Date : 2024-01-23 JaeSeong Hong, Sangchul Yoon, Kyu Won Shim, Yu Rang Park
BACKGROUND:Moyamoya disease (MMD) is a rare and complex pathological condition characterized by an abnormal collateral circulation network in the basal brain. The diagnosis of MMD and its progression is unpredictable and influenced by many factors. MMD can affect the blood vessels supplying the eyes, resulting in a range of ocular symptoms. In this study, we developed a deep learning model using real-world
-
Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association Stroke (IF 8.3) Pub Date : 2024-01-18 Rebecca F. Gottesman, Pamela L. Lutsey, Helene Benveniste, Devin L. Brown, Kelsie M. Full, Jin-Moo Lee, Ricardo S. Osorio, Matthew P. Pase, Nancy S. Redeker, Susan Redline, Adam P. Spira, on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, and Council on Hypertension
Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias. Sleep disorders such as sleep-disordered breathing (eg, obstructive sleep apnea), and other sleep disturbances, as well, some
-
High-Serum Brain-Derived Neurotrophic Factor Levels Are Associated With Decreased Risk of Poststroke Cognitive Impairment Stroke (IF 8.3) Pub Date : 2024-01-18 Xinyue Chang, Jiaxing You, Pinni Yang, Yu He, Yi Liu, Mengyao Shi, Daoxia Guo, Yanbo Peng, Jing Chen, Aili Wang, Tan Xu, Jiang He, Yonghong Zhang, Zhengbao Zhu
BACKGROUND:BDNF (brain-derived neurotrophic factor) is widely implicated in the pathophysiological process of stroke, but the effect of BDNF on poststroke cognitive impairment (PSCI) remains unclear. We aimed to investigate the association between baseline serum BDNF and the risk of PSCI at 3 months in a multicenter study based on a preplanned ancillary study of the CATIS trial (China Antihypertensive
-
Endovascular Treatment of Medium Vessel Occlusion Stroke Stroke (IF 8.3) Pub Date : 2024-01-18 Johanna M. Ospel, Thanh N. Nguyen, Ashutosh P. Jadhav, Marios-Nikos Psychogios, Frédéric Clarençon, Bernard Yan, Mayank Goyal
Approximately one-third of acute ischemic strokes with an identifiable vessel occlusion are caused by medium vessel occlusion (MeVO), that is, nonlarge vessel occlusions that are potentially amenable to endovascular treatment (EVT). Management of patients with MeVO is challenging in many ways: detecting MeVOs can be challenging, particularly for inexperienced physicians, and in busy clinical routine
-
Subarachnoid Hemorrhage Trials: Cutting, Sliding, or Keeping mRS Scores and WFNS Grades Stroke (IF 8.3) Pub Date : 2024-01-18 Akshitkumar M. Mistry, Jeffrey Saver, William Mack, Hooman Kamel, Jordan Elm, Jonathan Beall
Rigorous evidence generation with randomized controlled trials has lagged for aneurysmal subarachnoid hemorrhage (SAH) compared with other forms of acute stroke. Besides its lower incidence compared with other stroke subtypes, the presentation and outcome of patients with SAH also differ. This must be considered and adjusted for in designing pivotal randomized controlled trials of patients with SAH
-
Optimizing Educational Environments in Stroke and Neurovascular Fields. Stroke (IF 8.3) Pub Date : 2023-11-30 Amanda L Jagolino-Cole,Devin L Brown,Nicole Chiota-McCollum,Andrew M Southerland,David S Liebeskind
-
Outside the Laboratory Assessment of Upper Limb Laterality in Patients With Stroke: A Cross-Sectional Study. Stroke (IF 8.3) Pub Date : 2023-11-30 Philipp Gulde,Heike Vojta,Stephanie Schmidle,Peter Rieckmann,Joachim Hermsdörfer
BACKGROUND The rehabilitation of upper limb sensorimotor performance after stroke requires the assessment of daily use, the identification of key levels of impairment, and monitoring the course of recovery. It needs to be answered, how laboratory-based assessments and everyday behavior are connected, which dimension of metrics, that is, volume, intensity, or quality, is most sensitive to reduced function
-
Intermittent Theta-Burst Stimulation for Stroke: Primary Motor Cortex Versus Cerebellar Stimulation: A Randomized Sham-Controlled Trial. Stroke (IF 8.3) Pub Date : 2023-11-30 Ling-Yi Liao,Yang Zhu,Qiu-Yi Peng,Qiang Gao,Lu Liu,Qing-Hua Wang,Shi-Hao Gao,Yong Tao,Hao Huang,Pei-Dong Xu,Chang-Yue Gao
BACKGROUND Stroke survivors with impaired balance and motor function tend to have relatively poor functional outcomes. The cerebellum and primary motor cortex (M1) have been suggested as targets for neuromodulation of balance and motor recovery after stroke. This study aimed to compare the efficacy and safety of intermittent theta-burst stimulation (iTBS) to the cerebellum or M1 on balance and motor
-
Cerebrovascular Complications Associated With Iatrogenic Fungal Meningitis Following Surgical Procedures in Mexico. Stroke (IF 8.3) Pub Date : 2023-11-29 Andrea Becerril-Gaitan,Shivani Bindal,Samantha L Parker,Matthew P Mullarkey,Hussein A Zeineddine,Justine M Chen,Huimahn A Choi,Peng R Chen,Spiros Blackburn,Arthur Day,Luis F Torres,Robert J Brown,Ritvij Bowry,Ching-Jen Chen
BACKGROUND The current fungal meningitis outbreak caused by contaminated epidural anesthesia with Fusarium solani among patients who underwent surgical procedures in Matamoros, Mexico remains a cause of concern. Its association with an increased susceptibility for cerebrovascular complications (CVC) has not been reported. This single-center study describes 3 patients with a unique pattern of CVC attributed