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Changes of Serum Adiponectin Level in Patients with Obstructive Sleep Apnea Hypopnea Syndrome and Its Relationship with Sleep Monitoring Indexes Can. Respir. J. (IF 2.2) Pub Date : 2024-3-15 Ji Li, Kejing Zhou, Xing Chen
Objective. To observe the changes of serum adiponectin (AP) levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and explore the correlation between serum AP and polysomnography (PSG) parameters in patients with OSAHS. Methods. The data of subjects who underwent PSG at the hospital between January 2021 and December 2022 were collected retrospectively and divided into simple snoring
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Use of the Serum Level of Cholinesterase as a Prognostic Marker of Nonfatal Clinical Outcomes in Patients Hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease Can. Respir. J. (IF 2.2) Pub Date : 2024-3-12 Zhixiang Chen, Lei Zha, Bin Hu, Bin Xu, Lin Zuo, Jun Yang, Zhuhua Chu, Lingling Ma, Fangfang Hu
Introduction. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) contributes to a poor prognosis. Reliable biomarkers to predict adverse outcomes during hospitalization are important. Aim. To investigate the relationship between the serum cholinesterase (ChE) level and adverse clinical outcomes, including hypoxemia severity, hypercapnia, duration of hospital stay (DoHS), and noninvasive
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Efficacy of Definitive Radiotherapy for Patients with Clinical Stage IIIB or IIIC Lung Adenocarcinoma and Epidermal Growth Factor Receptor (EGFR) Mutations Treated Using First- or Second-Generation EGFR Tyrosine Kinase Inhibitors Can. Respir. J. (IF 2.2) Pub Date : 2024-3-5 Chih-Yen Tu, Te-Chun Hsia, Ying-Chun Lin, Ji-An Liang, Chia-Chin Li, Chun-Ru Chien
Background. The effectiveness of definitive radiotherapy (RT) for patients with clinical stage IIIB or IIIC lung adenocarcinoma and epidermal growth factor receptor (EGFR) mutations who received first- or second-generation EGFR tyrosine kinase inhibitors (TKIs) is unclear. Methods. Taiwan Cancer Registry data were used in this retrospective cohort study to identify adult patients diagnosed with EGFR-mutated
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Anlotinib Inhibits Cisplatin Resistance in Non-Small-Cell Lung Cancer Cells by Inhibiting MCL-1 Expression via MET/STAT3/Akt Pathway Can. Respir. J. (IF 2.2) Pub Date : 2024-3-4 Lile Wang, Lu Xu, Shuhua Han, Xiaoli Zhu
Background. Anlotinib is an effective targeted therapy for advanced non-small-cell lung cancer (NSCLC) and has been found to mediate chemoresistance in many cancers. However, the underlying molecular mechanism of anlotinib mediates cisplatin (DDP) resistance in NSCLC remains unclear. Methods. Cell viability was assessed by the cell counting kit 8 assay. Cell proliferation, migration, and invasion were
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Clustered Cystic Changes in Long-Term Follow-Up Thin-Section Computed Tomographic Findings in Fibrotic Nonspecific Interstitial Pneumonia Can. Respir. J. (IF 2.2) Pub Date : 2024-2-14 Masanori Akira, Narufumi Suganuma
Objectives. The purpose of this study was to retrospectively assess cystic changes in findings on follow-up CT scans of patients with fibrotic nonspecific interstitial pneumonia (NSIP). Methods. The initial and last high-resolution CT scans of 58 patients with pathologically proven fibrotic NSIP were evaluated retrospectively. The median follow-up periods were 48 months (range, 12–183 months). The
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Hypersensitivity Pneumonitis: Challenges of a Complex Disease Can. Respir. J. (IF 2.2) Pub Date : 2024-1-18 Diana Calaras, Aliona David, Eirini Vasarmidi, Katerina Antoniou, Alexandru Corlateanu
Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumonitis have been found to cover a wide range of occupations. As working practices have changed over time
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A Novel Scale to Assess Humidification during Noninvasive Ventilation: A Prospective Observational Study Can. Respir. J. (IF 2.2) Pub Date : 2023-12-28 Longfang Pan, Yueling Hong, Xiaoqing Zhong, Jiao He, Zuli Zhang, Qianru Zhao, Linfu Bai, Mengyi Ma, Jun Duan
Objective. To develop a novel scale to assess humidification during noninvasive ventilation (NIV). Methods. This study was performed in an ICU of a teaching hospital. Three ICU practitioners with more than 10 years of clinical experience developed an oral humidification scale with a range of 1–4 points. Each studied the current literature on humidification and examined 50 images of mouths of NIV patients
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Endobronchial Lipoma: A Rare Cause of Bronchial Stenosis or Obstruction Can. Respir. J. (IF 2.2) Pub Date : 2023-12-26 Jian Chen, Tao Xin, Lei Pan, Yan Li, Weisheng Qian, Jin Wei, Yan Yan, Yan Wang, Faguang Jin, Hua Jiang
Endobronchial lipoma (EL) is a rare benign tumor characterized by tracheobronchial smooth-surfaced mass, often resulting in bronchial obstruction without standard guidelines for management. This study seeks to clarify the clinical features and interventions of EL, aiming to improve its diagnosis and outcomes. A retrospective review was conducted on 28516 outpatients treated between January 2015 and
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Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression Can. Respir. J. (IF 2.2) Pub Date : 2023-11-29 Hongjuan He, Xiaoyan Ji, Lihua Cao, Zhenzhen Wang, Xiaoyu Wang, Xiu-Min Li, Mingsan Miao
Objective. Dysregulation of epithelial-mesenchymal transition (EMT) in the airway epithelium is associated with airway remodeling and the progression of pulmonary fibrosis. Many treatments have been shown to inhibit airway remodeling and pulmonary fibrosis progression in asthma and chronic obstructive pulmonary disease (COPD) by regulating EMT and have few side effects. This review aimed to describe
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Comparison of the Diagnostic Performance of Five Clinical Questionnaires for Chronic Obstructive Pulmonary Disease Can. Respir. J. (IF 2.2) Pub Date : 2023-11-24 Alirio R. Bastidas, Eduardo Tuta-Quintero, José S. Arias, Diana Cufiño, Diana Moya, Daniel Martin, Faure Rodríguez, Carolina Aponte-Murcia, Doris M. Pumarejo, Maria A. Bejarano, Geraldine Ospina, Lina M. Morales, Adriana M. Portella, Maria D. Barragán, Daniela A. Álvarez, José M. Hernández
Background. Chronic obstructive pulmonary disease (COPD) remains one of the most prevalent pathologies in the world and is among the leading causes of mortality and morbidity, partially due to underdiagnosis. The use of clinical questionnaires to identify high-risk individuals to take them to further diagnostic procedures has emerged as a strategy to address this problem. Objective. To compare the
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Prevalence of Sleep-Disordered Breathing in Prader–Willi Syndrome Can. Respir. J. (IF 2.2) Pub Date : 2023-10-26 Ahmed Abushahin, Amal Al-Naimi, Mutasim Abu-Hasan, Rania Arar, M. Lina Hayati, Antonisamy Belavendra, Ibrahim A. Janahi
Introduction. Sleep-disordered breathing (SDB) is common in patients with Prader–Willi Syndrome (PWS). However, the prevalence of SDB varies widely between studies. Early identification of SDB and factors contributing to its incidence is essential, particularly when considering growth hormone (GH) therapy. Objectives. The aims of the study were to describe the prevalence and phenotypes of sleep-disordered
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Effects of Conservative Oxygen Therapy versus Conventional Oxygen Therapy on the Mortality in ICU Patients: A Meta-Analysis Can. Respir. J. (IF 2.2) Pub Date : 2023-10-14 Xinyu Jiang, Dong Qiu
Objective. To compare the effects of conservative oxygen therapy and conventional oxygen therapy on the mortality of critically ill patients in ICU. Methods. Searching for randomized controlled clinical trials (RCT) on the effect of conservative oxygen therapy and conventional oxygen therapy on the mortality of critically ill patients in computer databases, including PubMed, Embase, Cochrane Library
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Long-Term Mortality following Acute Noninvasive Ventilation for Obesity-Related Respiratory Failure: A Retrospective Single-Centre Study Can. Respir. J. (IF 2.2) Pub Date : 2023-10-12 Aditya Krishnan, Paul Ellis, Pearlene Antoine-Pitterson, Amy Oakes, Bethany Jones, Alice Turner, Rahul Mukherjee
Introduction. Determinants of long-term mortality following acute hypercapnic respiratory failure have been extensively studied in patients with chronic obstructive pulmonary disease. However, respiratory failure due to obesity has not been studied to the same extent. This retrospective survey aims to identify whether admission pH is associated with long-term mortality in patients requiring acute noninvasive
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Noninvasive Home Mechanical Ventilation for Stable Hypercapnic COPD: A Clinical Respiratory Review from Canadian Perspectives Can. Respir. J. (IF 2.2) Pub Date : 2023-10-3 Rachel Jen, Colin Ellis, Marta Kaminska, Jeremy Road, Najib Ayas
Acute short-term noninvasive ventilation (NIV) for hypercapnic respiratory failure in chronic obstructive pulmonary disease (COPD) has well-established benefits; however, the role of long-term home NIV remains controversial. In the past decade, studies utilizing aggressive NIV settings to maximally reduce carbon dioxide levels (PaCO2) have resulted in several positive clinical trials and led to updated
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The Challenges of Spirometric Diagnosis of COPD Can. Respir. J. (IF 2.2) Pub Date : 2023-9-29 Adriana Maldonado-Franco, Luis F. Giraldo-Cadavid, Eduardo Tuta-Quintero, Alirio R. Bastidas Goyes, Daniel A. Botero-Rosas
Chronic obstructive pulmonary disease (COPD) is one of the top causes of morbidity and mortality worldwide. Although for many years its accurate diagnosis has been a focus of intense research, it is still challenging. Due to its simplicity, portability, and low cost, spirometry has been established as the main tool to detect this condition, but its flawed performance makes it an imperfect COPD diagnosis
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The Effects of Nebulized Inhaled Triptolide on Airway Inflammation in a Mouse Model of Asthma Can. Respir. J. (IF 2.2) Pub Date : 2023-8-21 Yafang Miao, Li Wei, Hao Chen, Zeming Zhang, Li Han
Inhalation of nebulized TP has received little attention in the past. Here, we intend to investigate the effect of nebulized inhaled TP on airway inflammation in a mouse model of asthma. 29 SPF BALB/c mice were divided into four groups: blank control (Blk, n = 5), normal saline (NS, n = 8), dexamethasone (Dex, n = 8), and TP (n = 8). During the process of sensitization, mice in the three intervention
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Nocturnal Hypoventilation in the Patients Submitted to Thoracic Surgery Can. Respir. J. (IF 2.2) Pub Date : 2023-8-9 Maciej Majchrzak, Cyryl Daroszewski, Piotr Błasiak, Adam Rzechonek, Paweł Piesiak, Monika Kosacka, Anna Brzecka
Introduction. Nocturnal hypoventilation may occur due to obesity, concomitant chronic obstructive pulmonary disease (COPD), obstructive sleep apnea, and/or the use of narcotic analgesics. The aim of the study was to evaluate the risk and severity of nocturnal hypoventilation as assessed by transcutaneous continuous capnography in the patients submitted to thoracic surgery. Materials and Methods. The
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Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage Can. Respir. J. (IF 2.2) Pub Date : 2023-7-28 Ning Du, Boxiang Zhang, Yunfeng Zhang
Background. Lung squamous cell carcinoma (LUSC) is a common malignancy. And the antitumor effect of bovine pox virus-associated kinase 1 (VRK1) is becoming a hot research topic. Methods. VRK1 expression and prognosis in LUSC were analyzed using the GEPIA database. The expression of VRK1 mRNA was detected in 25 LUSC clinical tissue samples by RT-PCR. VRK1 shRNA was transfected into LUSC NCI-H520 and
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Patient and Caregiver Perceptions of Airway Clearance Methods Used for Cystic Fibrosis Can. Respir. J. (IF 2.2) Pub Date : 2023-7-28 Zoe E. Kienenberger, Tyler O. Farber, Mary E. Teresi, Francesca Milavetz, Sachinkumar B. Singh, Katie Larson Ode, Theodosia Thoma, Rebecca L. Weiner, Kathryn R. Burlage, Anthony J. Fischer
Introduction. Cystic Fibrosis Foundation guidelines recommend people with CF perform daily airway clearance. This can be difficult for patients, as some find it time consuming or uncomfortable. Data comparing airway clearance methods are limited. We surveyed patients and their families to understand which methods are preferred and identify obstacles to performing airway clearance. Methods. We designed
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High-Flow Nasal Oxygen versus Noninvasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients: A Meta-Analysis of Randomized Controlled Trials Can. Respir. J. (IF 2.2) Pub Date : 2023-6-30 Yanping Du, Huaping Zhang, Zhiyi Ma, Jun Liu, Zhiyong Wang, Meixia Lin, Fayu Ni, Xi Li, Hui Tan, Shifan Tan, Yanling Chai, Xiangzhu Zhong
Background. High-flow nasal cannula (HFNC) can be used in stable chronic obstructive pulmonary disease (COPD) patients, but the effect of HFNC on clinical outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is still uncertain. Methods. We searched electronic literature databases for randomized controlled trials (RCTs) comparing HFNC with noninvasive ventilation
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer Can. Respir. J. (IF 2.2) Pub Date : 2023-6-21 Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun
Background. Immune checkpoint inhibitors (ICIs) have become a standard care in non-small-cell lung cancer (NSCLC). However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed to clarify the potential role of Yes1-associated transcriptional regulator (YAP1) in ICIs treatment for EGFR-mutant NSCLC population. Methods.
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Predictive Factors of Nonmalignant Pathological Diagnosis and Final Diagnosis of Ultrasound-Guided Cutting Biopsy for Peripheral Pulmonary Diseases Can. Respir. J. (IF 2.2) Pub Date : 2023-6-9 Qing Li, Li Zhang, Xinhong Liao, Yanfen Zhong, Zhixian Li
This study aimed to explore the predictive factors of nonmalignant pathological diagnosis and final diagnosis of ultrasound-guided cutting biopsy for peripheral pulmonary diseases. A total of 470 patients with peripheral lung disease diagnosed as nonmalignant by ultrasound-guided cutting biopsy in the First Affiliated Hospital of Guangxi Medical University from January 2017 to May 2020 were included
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Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting Can. Respir. J. (IF 2.2) Pub Date : 2023-5-25 Moegi Komura, Tadashi Sato, Yohei Suzuki, Hitomi Yoshikawa, Naoko Arano Nitta, Mika Hayashi, Eriko Kuwasaki, Kimiko Horikoshi, Toshihiko Nishioki, Mikiko Mori, Yuzo Kodama, Shinichi Sasaki, Kazuhisa Takahashi
Introduction. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils
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Prognostic Risk Factors of 30-Day Death in Traumatic Lower Limb Fracture Patients with Acute Pulmonary Embolism: A Single-Center Retrospective Study Can. Respir. J. (IF 2.2) Pub Date : 2023-5-10 Huanhuan Li, Yijun Yu, Yuting Wang, Qian Zhang, Ye Gu
Background. To explore the prognostic risk factors of 30-day death in patients with traumatic lower limb fracture (TLLF) complicated with acute pulmonary embolism (APE). Methods. 295 consecutive TLLF patients diagnosed as APE according to pulmonary artery CT angiography, hospitalized in our hospital from January 2017 to December 2021, were included in this study. Patients were divided into nonsurvival
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MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease Can. Respir. J. (IF 2.2) Pub Date : 2023-5-9 Chun Fang, Baoguo Kang, Pan Zhao, Jing Ran, Lifang Wang, Lingqiong Zhao, Hangyu Luo, Ling Tao
The aim of our study was to examine the production of monocyte chemoattractant protein (MCP-4) and eotaxin-3 during the onset and progression of COPD. The expression levels of MCP-4 and eotaxin-3 were evaluated in COPD samples and healthy controls using immunostaining and ELISA. The relationship between the clinic pathological features in the participants and the expression of MCP-4 and eotaxin-3 were
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Safety and Risk Factors of Needle Thoracentesis Decompression in Tension Pneumothorax in Patients over 75 Years Old Can. Respir. J. (IF 2.2) Pub Date : 2023-5-4 Yanhu Wang, Lei Wang, Cheng Chen, Yifan Que, Yinyi Li, Jiang Luo, Ming Yin, Miao Lv, Guogang Xu
Background. There are very few professional recommendations or guidelines on the needle thoracentesis decompression (NTD) for the tension pneumothorax in the elderly. This study aimed to investigate the safety and risk factors of tension pneumothorax NTD in patients over 75 years old based on CT evaluation of the chest wall thickness (CWT). Methods. The retrospective study was conducted among 136 in-patients
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Association of Upon-Diagnosis Blood Eosinophilic Count with Frequency and Severity of Annual Exacerbation in Chronic Obstructive Pulmonary Disease: A Prospective Longitudinal Analysis Can. Respir. J. (IF 2.2) Pub Date : 2023-4-26 Arda Kiani, Fatemehsadat Rahimi, Siamak Afaghi, Maryam Paat, Mohammad Varharam, Mehdi Kazempour Dizaji, Maryam Dastoorpoor, Atefeh Abedini
Introduction. There is a controversy regarding the relationship between blood eosinophil count and COPD exacerbation. We aimed to determine whether peripheral eosinophils upon COPD diagnosis could affect the frequency and severity of annual acute exacerbation of COPD (AECOPD). Methods. This prospective study was conducted on 973 newly diagnosed COPD patients who were under 1-year follow-up in a pulmonology
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High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study Can. Respir. J. (IF 2.2) Pub Date : 2023-4-15 Meng Wang, Feifan Zhao, Lina Sun, Ying Liang, Wei Yan, Xiaoyan Sun, Qingtao Zhou, Bei He
Background. Limited data are available about the clinical outcomes of AECOPD patients with respiratory acidosis treated with HFNC versus NIV. Methods. We conducted a retrospective study to compare the efficacy of HFNC with NIV as initial ventilation support strategy in AECOPD patients with respiratory acidosis. Propensity score matching (PSM) was implemented to increase between-group comparability
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Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis Can. Respir. J. (IF 2.2) Pub Date : 2023-4-15 Kazunobu Tachibana, Masanori Akira, Toru Arai, Chikatoshi Sugimoto, Seiji Hayashi, Yoshikazu Inoue
Background. Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality. Methods. We retrospectively reviewed clinical data including the pulmonary function tests
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Correlation between CT Score and KL-6: A Severity Assessing in Juvenile Dermatomyositis Associated Interstitial Lung Disease Can. Respir. J. (IF 2.2) Pub Date : 2023-3-27 Chi Wang, Jun Hou, Jianming Lai, Ran Tao, Yang Yang, Wenhan Hao, Xinyu Yuan, Yuchun Yan
Background. There is no radiological measurement to estimate the severity of pediatrics juvenile dermatomyositis (JDM) with interstitial lung disease (ILD). We validated the effectiveness of CT scoring assessment in JDM patients with ILD. Aim. To establish a CT scoring system and calculate CT scores in JDM patients with ILD and to determine its reliability and the correlation with Krebs von den Lungen-6
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Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis Can. Respir. J. (IF 2.2) Pub Date : 2023-3-14 You-Fan Peng, Jun-Hua Deng, Xiao-Ying Huang, Qing-Song Zhang
Aim. To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis. Methods. The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity. Results. Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients
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Validation of Sequential ROX-Index Score Beyond 12 Hours in Predicting Treatment Failure and Mortality in COVID-19 Patients Receiving Oxygen via High-Flow Nasal Cannula Can. Respir. J. (IF 2.2) Pub Date : 2023-2-8 Dimitris Basoulis, Pantelis Avramopoulos, Maria Aggelara, Georgios Karamanakos, Pantazis-Michail Voutsinas, Amalia Karapanou, Mina Psichogiou, Michalis Samarkos, Foteini Ntziora, Nikolaos V. Sipsas
Background. High-flow nasal cannula (HFNC) is an oxygen delivery method shown to reduce the risk of intubation and mortality in patients with type 1 respiratory failure. The ROX-index score can predict HFNC failure. This study aims to evaluate sequential ROX-index assessments as predictors of HFNC failure and mortality. Methods. Prospective observational single-center study including all adult patients
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ILD-GAP Combined with the Charlson Comorbidity Index Score (ILD-GAPC) as a Prognostic Prediction Model in Patients with Interstitial Lung Disease Can. Respir. J. (IF 2.2) Pub Date : 2023-2-8 Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami, Kota Murohashi, Ryo Nagasawa, Ayako Aoki, Ami Izawa, Kenichi Seki, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
Background. The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated. Methods. In ILD patients, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis Can. Respir. J. (IF 2.2) Pub Date : 2023-1-18 Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma, often manifested by dyspnea and progressive loss of lung function. The role of inflammation in the pathogenesis of IPF is not well understood. This study evaluated the histopathological and inflammatory components of bleomycin-induced pulmonary
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Construction and Validation of a Predictive Model for the Risk of Ventilator-Associated Pneumonia in Elderly ICU Patients Can. Respir. J. (IF 2.2) Pub Date : 2023-1-12 Shuhua Li, Linping Shang, Lirong Yuan, Wei Li, Hongyun Kang, Wenting Zhao, Xiaojuan Han, Danxia Su
Background. Ventilator-associated pneumonia (VAP) is among the most important hospital-acquired infections in an intensive-care unit setting. However, clinical practice lacks effective theoretical tools for preventing VAP in the elderly. Aim. To describe the independent factors associated with VAP in elderly intensive-care unit (ICU) patients on mechanical ventilation (MV) and to construct a risk prediction
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Operative versus Nonoperative Treatment in Patients with Advanced Non-Small-Cell Lung Cancer: Recommended for Surgery Can. Respir. J. (IF 2.2) Pub Date : 2023-1-12 Hui Wang, Di Yang, Yan Lv, Jing Lin, Haibin Wang
Background. There is currently limited evidence for a correlation between the recommended operation and overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC). Methods. NSCLC patients with stages III and IV, recommended for operation, were identified in the US National Cancer Institute Surveillance, Epidemiology, and End Results database (SEER).We used propensity score matching
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Evaluation of Follow-Up CT Scans in Patients with Severe Initial Pulmonary Involvement by COVID-19 Can. Respir. J. (IF 2.2) Pub Date : 2022-12-29 Behshad Pazooki, Ailar Ahangari, Mohammad-Mehdi Mehrabi Nejad, Nasim Batavani, Faeze Salahshour
Objective. To investigate the predictive factors of residual pulmonary opacity on midterm follow-up CT scans in patients hospitalized with COVID-19 pneumonia. Materials and Methods. This prospective study was conducted in a tertiary referral university hospital in Iran, from March 2020 to December 2020. Patients hospitalized due to novel coronavirus pneumonia with bilateral pulmonary involvement in
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma Can. Respir. J. (IF 2.2) Pub Date : 2022-12-20 Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang
Asthma is a chronic inflammatory disturbance of the airways in which many cells and cellular elements are involved. Wheezing, breathlessness, chest tightness, and coughing, especially at night or in the early morning, are typical symptoms of asthma. At present, inhaled corticosteroid (ICS) and long-acting β-agonists (LABAs) are standard treatments for regular management. Oral corticosteroids (OCSs)
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A Nomogram Model for Mortality Risk Prediction in Pulmonary Tuberculosis Patients Subjected to Directly Observed Treatment Shortcourse (DOTS) Can. Respir. J. (IF 2.2) Pub Date : 2022-12-16 Yi Xie, Jing Han, Weili Yu, Zhili Hou, Zhen Wan
We analyzed the risk factors of mortality for patients with pulmonary tuberculosis under the Directly Observed Treatment Shortcourse (DOTS) and established a predictive nomogram for the risk of mortality. The retrospective cohort analysis was conducted on the treatment outcomes of 11207 tuberculosis patients in the tuberculosis management information system in Tianjin from 2014 to 2019. Based on the
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Characteristics, Management, and Outcomes of Community-Acquired Pneumonia Due to Human Rhinovirus—A Retrospective Study Can. Respir. J. (IF 2.2) Pub Date : 2022-12-9 Ibrahim Bahabri, Abdulaziz Abdulaal, Thamer Alanazi, Sultan Alenazy, Yasser Alrumih, Rakan Alqahtani, Mohammad Bosaeed, Hasan M. Al-Dorzi
Introduction. Human rhinovirus (HRV) can lead to a variety of respiratory illnesses; it is also an uncommon cause of community-acquired pneumonia (CAP). We described the characteristics and outcomes of patients hospitalized for CAP due to HRV. Methods. We retrospectively studied consecutive adult patients admitted to King Abdulaziz Medical City-Riyadh with CAP due to HRV between 2016 and 2019. The
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MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD Can. Respir. J. (IF 2.2) Pub Date : 2022-12-5 Lei Fang, Xinggang Wang, Ming Zhang, Petra Khan, Michael Tamm, Michael Roth
Background. Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function. It also modifies mTOR activity, microRNA (miR)-101-3p expression, and mitochondria function. Here, the link between miR-101-3p and mTOR-regulated mitochondria integrity and ASMC deterioration was assessed. Methods. Disease-specific
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Deep Learning Models to Predict Fatal Pneumonia Using Chest X-Ray Images Can. Respir. J. (IF 2.2) Pub Date : 2022-11-24 Satoshi Anai, Junko Hisasue, Yoichi Takaki, Naohiko Hara
Background and Aims. Chest X-ray (CXR) is indispensable to the assessment of severity, diagnosis, and management of pneumonia. Deep learning is an artificial intelligence (AI) technology that has been applied to the interpretation of medical images. This study investigated the feasibility of classifying fatal pneumonia based on CXR images using deep learning models on publicly available platforms.
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Cost-Effectiveness of a New Outpatient Pulmonology Care Model Based on Physician-to-Physician Electronic Consultation Can. Respir. J. (IF 2.2) Pub Date : 2022-10-31 José Manuel Álvarez-Dobaño, Malena Toubes, José Ángel Novo-Platas, Francisco Reyes-Santías, Gerardo Atienza, Manuel Portela, Carlos Rábade, Tamara Lourido, Ana Casal, Carlota Rodríguez-García, Vanessa Riveiro, Romina Abelleira, Jorge Ricoy, Nuria Rodríguez-Núñez, Carlos Zamarrón, Felipe Calle, Francisco Gude, Luis Valdés
Introduction. This study assesses the impact of an electronic physician-to-physician consultation program on the waiting list and the costs of a Pulmonology Unit. Materials and Methods. A prepost intervention study was conducted after a new ambulatory pulmonary care protocol was implemented and the capacity of the unit was adopted. In the new model, physicians at all levels of healthcare send electronic
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Efficacy of Intrapleural or Intrapericardial Injection of Single Bevacizumab in the Treatment of Lung Cancer-Mediated Malignant Effusion Can. Respir. J. (IF 2.2) Pub Date : 2022-10-31 Dongyun He, Zhihua Guo, Zixian Xie, Yalei Zhang, Qiuhua Deng, Haihong Yang
The usage of bevacizumab for malignant pleural effusion (MPE) or malignant pericardial effusion (MPCE) has attracted increasing interest from researchers, but the precise ways of bevacizumab administration remain unknown. Patients with histologically or cytologically confirmed non-small-cell lung cancer (NSCLC) with MPE or MPCE were enrolled in the study and treated with a low dose of single bevacizumab
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Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) Can. Respir. J. (IF 2.2) Pub Date : 2022-10-19 Jia-Ying Luo, Hui-An Chen, Yuan-Yu Feng, Ye-Peng Chen, Xiang-Cheng Lei, Shuang-Lin Guo, Xiao-Bin Huang, Zhi-Man Liang, Ning Li, Bao-Qing Sun
Background. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences of blood eosinophil counts between asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD
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Feasibility of Using High-Resolution Computed Tomography Features for Invasiveness Differentiation of Malignant Nodules Manifesting as Ground-Glass Nodules Can. Respir. J. (IF 2.2) Pub Date : 2022-10-17 Xinyue Chen, Benbo Yao, Juan Li, Chunxiao Liang, Rui Qi, Jianqun Yu
Ground-glass nodule (GGN)-like adenocarcinoma is a special subtype of lung cancer. The invasiveness of the nodule correlates well with the patient’s prognosis. This study aimed to establish a radiomic model for invasiveness differentiation of malignant nodules manifesting as ground glass on high-resolution computed tomography (HRCT). Between January 2014 and July 2019, 276 pulmonary nodules manifesting
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The Nutritional Status of Chronic Obstructive Pulmonary Disease Exacerbators Can. Respir. J. (IF 2.2) Pub Date : 2022-10-13 Carina Rôlo Silvestre, Tiago Dias Domingues, Luís Mateus, Maria Cavaco, André Nunes, Ricardo Cordeiro, Teresa Silva Santos, Teresa Falcão, António Domingos
Introduction. Malnutrition is underdiagnosed in chronic obstructive pulmonary disease. Objectives. This study aimed to evaluate the nutritional status of COPD patients and the link between dyspnea and nutritional status. Methods. This longitudinal observational study included patients hospitalized with exacerbated COPD. Nutritional status was assessed using Nutrition Risk Screening 2002, anthropometric
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A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome Can. Respir. J. (IF 2.2) Pub Date : 2022-10-13 Shengyuan Wang, Shanshan Niu, Siwan Wen, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Li Yu, Xianghuai Xu
Objective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants
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Effects of Different Intervention Factors on Vascular Endothelial Growth Factor-Induced Human Airway Smooth Muscle Cell Migration Can. Respir. J. (IF 2.2) Pub Date : 2022-10-10 Chengtian Lv, Guangyuan Liao, Lichan Wu, Jing Li, Yuanmei Gao
Background. Asthma airway remodeling is closely related to the abnormal migration of human airway smooth muscle cells (ASMCs), and vascular endothelial growth factor (VEGF) is involved in the pathophysiological process of asthma. This study aimed to investigate the effect of VEGF on ASMC migration through in vitro cell experiments and to intervene in ASMC migration with different asthma drugs and signaling
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Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence Can. Respir. J. (IF 2.2) Pub Date : 2022-10-4 Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu
Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and progressive interstitial lung disease characterized by recurrent alveolar epithelial cell injury, fibroblast hyperproliferation, and cumulative deposition of extracellular matrix leading to alveolar destruction in the lungs. Mitotic arrest deficient 2 like 1 (MAD2L1) is a component of the mitotic spindle assembly checkpoint that prevents
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Nasopharyngeal Wash with Normal Saline Decreases SARS-CoV-2 Viral Load: A Randomized Pilot Controlled Trial Can. Respir. J. (IF 2.2) Pub Date : 2022-9-27 I. Pantazopoulos, A. Chalkias, G. Mavrovounis, I. Dimeas, S. Sinis, A. Miziou, E. Rouka, K. Poulas, K. Gourgoulianis
Background. Although great progress has been made over the past 2 years in the scientific understanding of the biology, epidemiology, and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), case morbidity and fatality rates remain a great concern and continue to challenge the healthcare resources worldwide as novel variants emerge. There is therefore an urgent need for affordable
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Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System Can. Respir. J. (IF 2.2) Pub Date : 2022-9-26 Farzaneh Ketabchi, Sina Jamzad
Two and a half years after COVID-19 was first reported in China, thousands of people are still dying from the disease every day around the world. The condition is forcing physicians to adopt new treatment strategies while emphasizing continuation of vaccination programs. The renin-angiotensin system plays an important role in the development and progression of COVID-19 patients. Nonetheless, administration
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Perioperative Exhaled Nitric Oxide as an Indicator for Postoperative Pneumonia in Surgical Lung Cancer Patients: A Prospective Cohort Study Based on 183 Cases Can. Respir. J. (IF 2.2) Pub Date : 2022-09-04 Gui-Xian Liu, Yue Yang, Lei Chen, Mi-Qi Gu, Jin-Tao He, Xin Wang
Introduction. This study is conducted to investigate the correlation between perioperative fractional exhaled nitric oxide and postoperative pneumonia (POP) and the feasibility of perioperative FeNO for predicting POP in surgical lung cancer patients. Methods. Patients who were diagnosed with non-small-cell lung cancer (NSCLC) were prospectively analyzed, and the relationship between perioperative
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ADAM33 Silencing Inhibits Vascular Smooth Muscle Cell Migration and Regulates Cytokine Secretion in Airway Vascular Remodeling via the PI3K/AKT/mTOR Pathway Can. Respir. J. (IF 2.2) Pub Date : 2022-08-31 Fang Yan, Xin Hu, Long He, Kegang Jiao, Yanyan Hao, Jing Wang
Introduction. Vascular smooth muscle cells (VSMCs) are highly involved in airway vascular remodeling in asthma. Objectives. This study aimed to investigate the mechanisms underlying the effects of a disintegrin and metalloproteinase-33 (ADAM33) gene on the migration capacity and inflammatory cytokine secretion of VSMCs. Methods. Human aortic smooth muscle cells (HASMCs) were transfected with lentiviral
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Noninvasive Ventilation in Treatment of Respiratory Failure-Related COVID-19 Infection: Review of the Literature Can. Respir. J. (IF 2.2) Pub Date : 2022-08-31 Bushra Mina, Alexander Newton, Vijay Hadda
The recently diagnosed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in December 2019 commonly affects the respiratory system. The incidence of acute hypoxic respiratory failure varied among epidemiological studies with high percentage of patients requiring mechanical ventilation with a high mortality. Noninvasive ventilation is an alternative
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Characteristics and Prognostic Nomogram for Primary Lung Lepidic Adenocarcinoma Can. Respir. J. (IF 2.2) Pub Date : 2022-08-31 Hui Tang, Caixia Qiao, Yingyi Wang, Chunmei Bai
Background. Lepidic adenocarcinoma (LPA) is an infrequent subtype of invasive pulmonary adenocarcinoma (ADC). However, the clinicopathological features and prognostic factors of LPA have not been elucidated. Methods. Data from the Surveillance, Epidemiology, and End Results (SEER) database of 4191 LPA patients were retrospectively analyzed and compared with non-LPA pulmonary ADC to explore the clinicopathological
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis Can. Respir. J. (IF 2.2) Pub Date : 2022-08-29 Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu
Pulmonary arterial hypertension (PAH) is a progressive and complex pulmonary vascular disease with poor prognosis. The aim of this study was to provide a new understanding of the pathogenesis of disease and potential treatment targets for patients with PAH based on multiple-microarray analysis.Two microarray datasets (GSE53408 and GSE113439) downloaded from the Gene Expression Omnibus (GEO) database
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Viral RNA Load in Symptomatic and Asymptomatic COVID-19 Omicron Variant-Positive Patients Can. Respir. J. (IF 2.2) Pub Date : 2022-08-29 Qian Wu, Lixia Shi, Haomin Li, Shuping Huang, Hongwei Li, Li Li, Jin Han, Qi Wu, Zhengcun Pei
Objectives. Viral load is important when evaluating viral transmission potential, involving the use of a polymerase chain reaction (PCR) cycle threshold (Ct) value. We aimed to analyze the PCR Ct values of respiratory tract samples taken from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant strains to evaluate these strains’ viral dynamics. Methods. This study
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The Efficacy and Cost-Effectiveness of Umeclidinium/Vilanterol versus Tiotropium in Symptomatic Patients with Chronic Obstructive Pulmonary Disease Can. Respir. J. (IF 2.2) Pub Date : 2022-08-25 Yinhua Gong, Chen Lin, Yifeng Jin, Rong Chen
Background. Both long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) are widely used in the treatment of chronic obstructive pulmonary disease (COPD). A novel LAMA/LABA combination of umeclidinium/vilanterol (UMEC/VI; 62.5 μg/25 μg) is approved for chronic obstructive pulmonary disease (COPD) treatment. Objective. This study aimed to assess the efficacy and cost-effectiveness
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Small Airway Dysfunction in Chronic Bronchitis with Preserved Pulmonary Function Can. Respir. J. (IF 2.2) Pub Date : 2022-08-24 Qi Ding, Bai-Bing Mi, Xia Wei, Jie Li, Jiu-Yun Mi, Jing-Ting Ren, Rui-Li Li
Impairment of pulmonary function was evaluated in chronic bronchitis patients with preserved ratio impaired spirometry (PRISm). We retrospectively collected clinical data from 157 chronic bronchitis (CB) and 186 chronic obstructive pulmonary disease (COPD) patients between October 2014 and September 2017. These patients were assigned to three groups: control (normal pulmonary function), PRISm (forced