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Level of Education Modifies Asthma Mortality in Norway and Sweden. The Nordic EpiLung Study J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-18 Helena Backman, Laxmi Bhatta, Linnea Hedman, Ben Brumpton, Iida Vähätalo, Paul G Lassmann-Klee, Bright I Nwaru, Linda Ekerljung, Steinar Krokstad, Sigrid Anna Aalberg Vikjord, Anne Lindberg, Hannu Kankaanranta, Eva Rönmark, Arnulf Langhammer
Background and Aim: The relationship between socioeconomic status (SES), asthma and mortality is complex and multifaceted, and it is not established if educational level modifies the association between asthma and mortality. The aim was to study the association between asthma and mortality in Sweden and Norway and to what extent educational level modifies this association. Participants and Methods:
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Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-15 Ting-Yu Lin, Firdian Makrufardi, Nguyen Thanh Tung, Amja Manullang, Po-Jui Chang, Chun-Yu Lo, Tzu-Hsuan Chiu, Pi-Hung Tung, Chiung-Hung Lin, Horng-Chyuan Lin, Chun-Hua Wang, Shu-Min Lin
Background: Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air pollution (TRAP) on asthma outcomes in EOA and LOA patients. Methods: A cross-sectional study was conducted on 675 asthma patients (LOA: 415) recruited
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Primary Care Asthma Attack Prediction Models for Adults: A Systematic Review of Reported Methodologies and Outcomes J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-14 Lijun Ma, Holly Tibble
Abstract: Prognostic models hold great potential for predicting asthma exacerbations, providing opportunities for early intervention, and are a popular area of current research. However, it is unclear how models should be compared and contrasted, given their differences in both design and performance, particularly with a view to potential implementation in routine practice. This systematic review aimed
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Risk Factors for Severe Seafood Allergy Among Adults in an Urban City in Vietnam J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-12 Tu HK Trinh, Chi N Duong, Tu HT Pham, Hao DT Au, Loc T Tran, Cuong V Nguyen, Han BG Nguyen, Nguyen M Tran, Quy Q Phan, Thu NA Le, Nga Nguyen
Purpose: Increasing seafood consumption is associated with more frequent reports of food allergy. Little is known about seafood allergy (SFA) among adults in Vietnam. We investigated the characteristics of individuals with SFA and the risk factors for severe SFA. Patients and methods: A cross-sectional, web-based survey was conducted among individuals aged ≥ 18 years from universities in Ho Chi Minh
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A Case of Type I Food Allergy Induced by Monosodium Glutamate J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-07 Reeko Osada, Chiyako Oshikata, Yuichi Kurihara, Kosuke Terada, Yuka Kodama, Yuga Yamashita, Ryo Nakadegawa, Hinako Masumitsu, Yuto Motobayashi, Hirokazu Takayasu, Nami Masumoto, Saki Manabe, Yingyao Zhu, Ryo Tanaka, Takeshi Kaneko, Aya Sasaki, Naomi Tsurikisawa
Abstract: Monosodium glutamate (MSG), a salt form of a non-essential amino acid, is widely used as a food additive, particularly in Asian cuisines, due to its unique flavor-enhancing qualities. Type I allergic reactions to MSG have not previously been reported. Our patient, a 21-year-old woman, was 14 years old when she first noticed swelling of her tongue (but no oral itching, diarrhea, or abdominal
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Impact of Exacerbation History on Dupilumab Efficacy in Children with Uncontrolled Moderate-to-Severe Asthma: LIBERTY ASTHMA VOYAGE Study J. Asthma Allergy (IF 3.2) Pub Date : 2024-03-05 Theresa W Guilbert, Alberto Tolcachier, Alessandro G Fiocchi, Constance H Katelaris, Wanda Phipatanakul, Philippe Begin, Inés de Mir, Arman Altincatal, Rebecca Gall, Olivier Ledanois, Amr Radwan, Juby A Jacob-Nara, Yamo Deniz, Paul J Rowe
Purpose: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukins-4/-13, key and central drivers of type 2 inflammation in multiple diseases. This post hoc analysis of the Phase 3 LIBERTY ASTHMA VOYAGE study (NCT02948959) evaluated the efficacy of dupilumab in children aged 6 to 11 years with moderate-to-severe asthma with a type 2 inflammatory phenotype (blood
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Analysis of the Construction of a Predictive Model for Eosinophilic Chronic Rhinosinusitis J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-28 Shuo Wu, Jiahong Lao, Feitong Jian
Purpose: This study aimed to determine indices to diagnose and predict eosinophilic chronic rhinosinusitis (ECRS) during the initial clinic visit. Patients and Methods: We retrospectively analyzed 116 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery and were classified according to the postoperative pathological diagnosis. General data and various clinical indicators were
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Clinical Experience with Berotralstat in Patients with Hereditary Angioedema with Normal C1-Esterase Inhibitor: A Commented Case Series J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-23 Henry J Kanarek, Drew Austin Saville Mutschelknaus
Abstract: Hereditary angioedema (HAE) is a rare genetic disorder characterized by potentially life-threatening episodes of swelling. Most HAE cases are caused by deficient (type I) or dysfunctional (type II) C1-esterase inhibitor (C1-INH) protein. However, some patients present with a subtype of HAE that is associated with normal plasma levels of functional C1-INH protein and complement component 4
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What is the Best Way to Diagnose Possible Asthma Patients with Negative Bronchodilator Reversibility Tests? J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-22 Buket Başa Akdoğan, Ilkay Koca Kalkan, Gözde Köycü Buhari, Özlem Özdedeoğlu, Hale Ateş, Kurtuluş Aksu, Ferda Öner Erkekol
Objective: The best method and strategy for the diagnosis of asthma remains unclear, especially in patients with negative bronchodilator reversibility test (BDRT). In our study, we aimed to investigate the diagnostic yield of peak expiratory flow (PEF) variability for this patient group. Methods: A total of 50 patients with suspected asthma, all with negative BDR test, were included in the study. Demographic
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New Insights into Mechanisms Traditional Chinese Medicine for Allergic Rhinitis by Regulating Inflammatory and Oxidative Stress Pathways J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-19 Zhu Qin, Liangzhen Xie, Wentao Li, Chao Wang, Yan Li
Abstract: Allergy rhinitis (AR) is becoming more common and has serious medical and societal consequences. Sneezing, paroxysmal nasal blockage, nasal itching, mucosal edema, coughing, and rhinorrhea are symptoms of this type I allergic immunological illness. Immunoglobulin E-mediated inflammation is the cause of it. Because AR is prone to recurrent attacks, extended medication therapy may impair its
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Inhibitory Effect of Apolipoprotein A-I on Eosinophils in Allergic Rhinitis in vitro and in vivo J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-13 Yinhui Zeng, Jinyuan Li, Yueqiang Wen, Haiqing Xiao, Chao Yang, Qingxiang Zeng, Wenlong Liu
Purpose: Eosinophils have pivotal roles in the development of allergic rhinitis (AR) through the release of cytotoxic substances. Apolipoprotein A-I (Apo-AI) exhibits a strong inhibitory effect on eosinophil infiltration in allergic diseases. Nevertheless, the precise impact of Apolipoprotein A-I on eosinophils remains uncertain. Methods: Our study recruited a total of 15 AR children and 15 controls
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Impact of Lung Function on Asthma Exacerbation Rates in Children Treated with Dupilumab: The VOYAGE Study J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-08 Theresa W Guilbert, Kevin R Murphy, Eckard Hamelmann, Kristie R Ross, Atul Gupta, Alessandro Fiocchi, Changming Xia, Rebecca Gall, Olivier Ledanois, Amr Radwan, Juby A Jacob-Nara, Paul J Rowe, Yamo Deniz
Background: Severe, uncontrolled asthma and asthma exacerbations in children are associated with abnormal lung function and airway development, and increased risk of chronic obstructive lung disease in adulthood. The rationale for this post hoc analysis was to explore the relationship between changes in asthma exacerbation rates and lung function in children treated with dupilumab. Methods: This post
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Smoking, Urban Housing and Work-Aggravated Asthma are Associated with Asthma Severity in a Cross-Sectional Observational Study J. Asthma Allergy (IF 3.2) Pub Date : 2024-02-01 Marie Chevereau-Choquet, Benjamin Thoreau, Camille Taillé, Sylvain Marchand-Adam, Hugues Morel, Laurent Plantier, Laurent Portel
Purpose: Severe asthma affects 5 to 10% of asthmatics and accounts for a large part of asthma-related morbidity and costs. The determinants of asthma severity are poorly understood. We tested the hypothesis that asthma severity was associated with 1) atopy and allergy and 2) markers associated with environmental exposure. Patients and Methods: Data from the FASE-CPHG study, a cross-sectional, observational
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A Longitudinal Study of a Selected Pediatric Asthmatic Population with Normal and Abnormal Spirometry at Baseline: An Emphasis on Treatment Outcomes J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-20 Sornsiri Yimlamai, Kanokpan Ruangnapa, Wanaporn Anuntaseree, Kantara Saelim, Pharsai Prasertsan, Kantisa Sirianansopa
Purpose: It is still unclear whether considering abnormal spirometry as a marker for disease control can help physicians adjust asthma controllers in children because of the scarcity of pediatric studies. We aimed to investigate the prevalence of abnormal spirometry in a selected pediatric asthmatic population and its effect on longitudinal outcomes. Patients and Methods: This retrospective cohort
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Real-World Safety and Effectiveness of Benralizumab in Japanese Patients with Severe Asthma: A Multicenter Prospective Observational Study J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-20 Masao Yamaguchi, Yoshihiro Nishimura, Yuko Takumi, Nobuya Hayashi, Kei Sakamoto, Yuji Tohda
Introduction: This study aimed to demonstrate whether benralizumab maintained the safety and effectiveness profiles established in randomized controlled trials among all patients with severe uncontrolled asthma initially prescribed benralizumab in the real-world setting in Japan. Methods: This was a prospective, observational, multicenter post-marketing study (ClinicalTrial.gov, NCT03588546). The safety
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Prevalence and Risk Factors of Childhood Asthma in Jazan Region, Saudi Arabia J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-20 Gassem Gohal, Abuobaida Yassin, Hussam Darraj, Anwar Darraj, Rawan Maghrabi, Yumna Barakat Abutalib, Sarah Talebi, Amani Ahmed Mutaen, Sulaiman Hamdi
Background: The prevalence of asthma among children has been on the rise worldwide, leading to significant morbidity and mortality. Our study was conducted to determine the prevalence of asthma and its related risk factors among school-age children in the Jazan Region, Saudi Arabia. Materials and Method: The study was a cross-sectional prospective study that used Phase I ISAAC protocol and was conducted
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Bronchodilator Responsiveness Measured by Spirometry and Impulse Oscillometry in Patients with Asthma After Short Acting Antimuscarinic and/or Beta-2-Agonists Inhalation J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-19 Nicole MD van der Burg, Carl Ekelund, Leif H Bjermer, David Aronsson, Jaro Ankerst, Ellen Tufvesson
Background: Bronchodilator responsiveness (BDR) in asthma involves both the central and peripheral airways but is primarily relieved with beta-2-agonists and evaluated by spirometry. To date, antimuscarinics can be added as a reliever medication in more severe asthma. We hypothesize that combining both short-acting beta-2 agonist (SABA) and short-acting muscarinic antagonist (SAMA) could also improve
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A Retrospective Claims Database Study to Clarify Treatment Reality of Asthma Patients Before and After Referral to a Specialist J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-18 Soichiro Hozawa, Keita Ono, Naoyuki Makita, Hitomi Uchimura, Yoshifumi Arita, Takehiro Hirai, Naoki Tashiro
Purpose: Japanese guidelines recommend that patients with uncontrolled asthma be referred by non-specialists to specialists (allergists and/or pulmonologists). This study investigated the reality of clinical practice in asthma patients referred to specialists in Japan. Patients and Methods: This was a retrospective, observational cohort study of asthma patients in a health insurance claim database
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Dupilumab Reduces Asthma Disease Burden and Recurrent SCS Use in Patients with CRSwNP and Coexisting Asthma J. Asthma Allergy (IF 3.2) Pub Date : 2024-01-16 Mark Gurnell, Amr Radwan, Claus Bachert, Njira Lugogo, Seong H Cho, Scott Nash, Haixin Zhang, Asif H Khan, Juby A Jacob-Nara, Paul J Rowe, Yamo Deniz
Purpose: Dupilumab significantly reduced the requirement for systemic corticosteroids (SCS) in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). Patients with CRSwNP and coexisting asthma typically have a higher disease burden and have more difficulty in managing disease. Here, we report an analysis of asthma outcomes and SCS use in patients with CRSwNP and coexisting asthma.
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Factors Involved in Decision-Making Dilemmas Faced by Parents of Children with Severe Asthma in PICU During the Development of Discharge Care Plans: A Phenomenological Study J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-27 Guimei Fan, Mo Yi, Xiangmin Qiu, Jinfang Zhao
Purpose: This study aims to explore the complicated decision-making dilemma and challenges confronted by parents of children suffering from severe asthma within the Pediatric Intensive Care Unit (PICU) when participating in the development of their children’s discharge care plans. Patients and Methods: Employing a phenomenological methodology, a purposive sampling was performed to engage with 17 parents
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Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti-IL5 Treatments [Letter] J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-23 Muhammad Ifham Hanif, Bagus Muhammad Ihsan, Mentari Maratus Sholihah
Letter for the article Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments
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How Does Mild Asthma Differ Phenotypically from Difficult-to-Treat Asthma? J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-19 Jennifer Naftel, Heena Mistry, Frances Ann Mitchell, Jane Belson, Mohammed Aref Kyyaly, Clair Barber, Hans Michael Haitchi, Paddy Dennison, Ratko Djukanovic, Gregory Seumois, Pandurangan Vijayanand, Syed Hasan Arshad, Ramesh J Kurukulaaratchy
Background: Despite most of the asthma population having mild disease, the mild asthma phenotype is poorly understood. Here, we aim to address this gap in knowledge by extensively characterising the mild asthma phenotype and comparing this with difficult-to-treat asthma. Methods: We assessed two real-world adult cohorts from the South of England using an identical methodology: the Wessex AsThma CoHort
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Lipocalin 2 (LCN2) Knockdown Regulates Treg/Th17 Balance to Improve Asthma in Mice J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-14 Le Xu, Minkang Shi
Purpose: Asthma substantially affects the quality of life and health of children. Lipocalin 2 (LCN2) is an immune-related protein, which is predicted to be highly expressed in asthma. Here, we investigated the role of LCN2 in ovalbumin (OVA)-induced asthma mouse model. Methods: We knocked down LCN2 in an asthma mouse model and performed histopathological analysis using hematoxylin and eosin (H&E) staining
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Real-World Study of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol on Asthma Control in the US J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-01 Michael Bogart, Guillaume Germain, François Laliberté, Malena Mahendran, Mei Sheng Duh, Kristi DiRocco, Stephen G Noorduyn, Rosirene Paczkowski, Ronald Balkissoon
Purpose: Real-world asthma control data among patients initiating fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) are limited. This study assessed rescue medication use and asthma-related exacerbations in patients with asthma before and after initiating single-inhaler FF/UMEC/VI using administrative claims data. Patients and Methods: This retrospective, pre-post cohort study analyzed data
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Characteristics of Allergic, Eosinophilic, and Overlapping Asthma Phenotypes Among Pediatric Patients with Current Asthma: A Cross-Sectional Study from Saudi Arabia J. Asthma Allergy (IF 3.2) Pub Date : 2023-12-01 Ali Alsuheel Asseri
Purpose: Asthma is one of the most common chronic diseases affecting 10%– 30% of children in Saudi Arabia. Although data exist on adult asthma phenotyping and endotyping in Saudi Arabia, little is known about asthma phenotypes in Saudi children. Patients and Methods: This cross-sectional study enrolled pediatric patients diagnosed with bronchial asthma and followed in the pediatric pulmonology clinic
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Multiple Biologics for Multiple T2 Diseases: A Pharmacoepidemiological Algorithm for Sorting Out Patients by Indication J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-29 Jeremy Charriot, Vincent Descamps, Roger Jankowski, Milka Maravic, Arnaud Bourdin
Background: Several biologics (Bx) and targeted synthetic drugs (TSD) exist to treat T2 diseases, including chronic spontaneous urticaria (CSU), severe asthma (SA), chronic rhinosinusitis with nasal polyposis (CRSwNP) or atopic dermatitis (AD). Objective: To identify patients treated with Bx/TSD from a dynamic dispensing database using an algorithm-based methodology. Methods: We used the LRx database
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Identifying Chili as a Risk Factor for the Geographic Tongue: A Case Report J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-23 Yessy Novianti, Nanan Nur’aeny
Introduction: Geographic tongue (GT) is a chronic tongue condition triggered by various factors such as immune reactions, allergies, stress, hereditary factors, and nutritional deficiencies. The prevalence of GT in the population ranges from 1% to 3%, and its symptoms can cause discomfort to patients. Spicy foods are popular among Indonesians. Chili is one such food that can cause allergies and trigger
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Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-21 Mona Al-Ahmad, Asmaa Ali, Mohammad Z Haider
Background: A significant link between T allele of the IL-4 (C590T) gene and developing asthma in some populations was reported. However, no study discussed the link between IL-4 (C590T) gene polymorphism and asthma severity groups (mild and severe). This study investigated the link between IL-4 gene variation and asthma severity. Methods: The study included 215 asthmatic patients, of which 102 had
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Characteristics of Induced-Sputum Inflammatory Phenotypes in Adults with Asthma: Predictors of Bronchial Eosinophilia [Corrigendum] J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-20 Astrid Crespo-Lessmann, Elena Curto, Eder Freddy Mateus Medina, Esther Palones, Alicia Belda Soler, Soraya Sánchez Maza, Lorena Soto-Retes, Vicente Plaza
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Errors in Metered Dose Inhaler Use Amongst Pediatric Asthma Patients J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-20 Eeshta Bhatt, Robert A Malkin
Purpose: The aim of this paper is to use easily accessible smartphones as a straightforward means for physicians to objectively check Medical Device Inhaler (MDI) technique, without the need for additional devices. Additionally, we seek to assess the frequency of inhaler technique errors and their impact on asthma control. Patients and Methods: Thirty-two children between the ages of 5 and 18 receiving
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Blueberry (Vaccinium myrtillus) Induced Anaphylaxis in a Chinese Child with Lipid Transfer Protein Sensitization J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-18 Nannan Jiang, Li Xiang, Hui Guan, Xudong Zhang
Purpose: Fruits have been identified as the primary triggers of anaphylaxis in older children in the Chinese population, especially among individuals with pollen sensitization. To date, no allergies have been reported after blueberry ingestion in the Chinese population. Case Report: A 12-year-old girl experienced one episode of anaphylaxis within 30 minutes of having breakfast (including milk, egg
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Online Survey to Investigate Asthma Medication Prescription and Adherence from the Perspective of Patients and Healthcare Practitioners in England [Letter] J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-14 Vernando Yanry Lameky
Letter for the article Online Survey to Investigate Asthma Medication Prescription and Adherence from the Perspective of Patients and Healthcare Practitioners in England
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Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-14 Xiaoyan Wang, Lijia Chen, Jiaqi Ding, Hongtian Wang, Xueyan Wang
Purpose: To investigate the major allergen components associated with birch pollen allergy in northern China and elucidate clinical relevance to pollen food allergy syndrome (PFAS). Methods: Fifty-eight patients were recruited for a cross-sectional study and categorized into two groups: PFAS group and non-PFAS group, as well as apple allergy group and non-apple allergy group. The sIgE levels of birch
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Dupilumab Treatment Efficacy and Impact on Clinical Scores, Serum Biomarkers, and Itch in Adult Patients with Atopic Dermatitis: A Retrospective Analysis J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-09 Mariateresa Rossi, Luca Bettolini, Grazia Linda Artelli, Alessandro Fraghì, Cesare Tomasi, Piergiacomo Calzavara-Pinton
Purpose: Dupilumab, a fully human monoclonal antibody that inhibits the signaling pathways of interleukin (IL)-4 and IL-13, has demonstrated remarkable efficacy in the treatment of atopic dermatitis (AD). Dupilumab has been reported to attenuate itch and reduce several serum markers, including blood lactate dehydrogenase (LDH), blood eosinophil count, and serum total immunoglobulin E (IgE). Patients
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Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-09 Michaela Barnikel, Ulrich Grabmaier, Pontus Mertsch, Felix Ceelen, Christian Janke, Jürgen Behr, Nikolaus Kneidinger, Katrin Milger
Abstract: Eosinophilic inflammation is a hallmark of asthma, and blood eosinophilia has been established as a biomarker for phenotyping asthma and predicting the response to anti-IL5 treatments. Although parasitic infections are rare in European adults, they remain an important differential diagnosis for blood eosinophilia. We present three patients with both domestic parasitic infections and asthma
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Effect of Air Pollutants and Meteorological Factors on Daily Outpatient Visits of Allergic Rhinitis in Hohhot, China J. Asthma Allergy (IF 3.2) Pub Date : 2023-11-01 Xue Wang, Chenghua Gao, Yuan Xia, Xiaoqian Xu, Lehui Li, Yan Liu, Xing Yao, Ning Cao, Zichao Li, Xin Fang
Objective: There is limited evidence that atmospheric pollutants are associated with the number of allergic rhinitis (AR) visits. This study aimed to investigate the relationship between atmospheric pollutants and meteorological factors and the number of daily visits for AR in Hohhot City, providing a theoretical basis for further research on the effects of atmospheric pollutants on AR. Methods: Microsoft
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Impact of Guideline-Based Asthma Treatment on Health Services Use in Singapore Before and During COVID-19 Outbreak J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-31 Laura Huey Mien Lim, Hui Fang Lim, Mei Fong Liew, Wenjia Chen
Introduction: To date, the role of standard asthma care in reducing asthma-related health services use (HSU) during the COVID-19 pandemic remains unclear. This study examined the impact of guideline-based asthma treatment on the use of asthma-related emergency department (ED) visits, polyclinic visits (total visits and urgent visits characterized by nebuliser use) before and during the pandemic. Methods:
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Clinical Characteristics of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Adolescents J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-30 Chien-Chia Huang, Po-Hung Chang, Yen-Lin Huang, Ta-Jen Lee, Chi-Che Huang, Pei-Wen Wu
Introduction: Eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is frequently associated with greater inflammation, poorer prognosis, and a high recurrence rate after sinus surgery. Objective: This study evaluated the clinical and imaging characteristics of eosinophilic CRSwNP in patients aged 12– 17. Methods: We retrospectively enrolled 139 patients aged 12– 17 with bilateral CRSwNP.
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Asthma and Susceptibility to COVID-19 in Australian Children During Alpha, Delta and Omicron Waves of the COVID-19 Pandemic [Corrigendum] J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-30 Mei Chan, Louisa Owens, Melinda Louise Gray, Hiran Selvadurai, Adam Jaffe, Nusrat Homaira
Corrigendum for the article Asthma and Susceptibility to COVID-19 in Australian Children During Alpha, Delta and Omicron Waves of the COVID-19 Pandemic
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Tracheobronchial Amyloidosis Accompanied with Asthma: A Case Report and a Mini-Review J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-28 Lina Sun, Kexin Liu, Meijiao Li, Yongchang Sun, Xiang Zhu, Chun Chang
Abstract: Tracheobronchial amyloidosis is a rare disease characterized by amyloid deposits on the tracheal and bronchial tissue. Patients with tracheobronchial amyloidosis are asymptomatic or exhibit symptoms, such as chronic wheezing, dyspnea, and cough, that are common manifestations of other disorders, including asthma. A bronchoscopic tissue biopsy using Congo red staining is the key standard for
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BDP/FF NEXThaler to Improve Asthma Control Status in the Real World: The NEWTON Study J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-25 Fulvio Braido, Enrico Arnaboldi, Sara Barile, Luca Cavalieri, Eleonora Ingrassia, Maria Russo, Alessio Piraino
Abstract: In this article, we discuss the importance of real-world data in the treatment of patients with asthma and specifically the role of maintenance and reliever therapy (MART) with beclometasone dipropionate (BDP)/formoterol fumarate dihydrate (FF) delivered through a dry-powder inhaler (DPI) that contains an extrafine formulation. We also present the design of the NEWTON study. This multinational
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The Interaction Between Asthma, Emotions, and Expectations in the Time of COVID-19 J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-20 Eleonora Volpato, Paolo Banfi, Francesco Pagnini
Introduction: The main aim was to gain insight into the experience of adult people with a diagnosis of at least 6-months of mild or moderate persistent asthma according to the Global Initiative for Asthma (GINA), and their emotions, beliefs, and expectations during the first wave of COVID-19. Methods: Qualitative semi-structured interviews using the Interpretative Phenomenological Analysis (IPA) were
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Asthma and Susceptibility to COVID-19 in Australian Children During Alpha, Delta and Omicron Waves of the COVID-19 Pandemic J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-13 Mei Chan, Louisa Owens, Melinda Louise Gray, Hiran Selvadurai, Adam Jaffe, Nusrat Homaira
Purpose: Earlier coronavirus-19 (COVID-19) pandemic reports did not implicate increased disease burden in asthmatics while subsequent findings have been inconsistent. To date, the impact of COVID-19 on childhood asthma remains undetermined and is further complicated with ongoing emergence of new variants. This study aimed to investigate association between asthma and COVID-19 for children in New South
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Suspected Rivaroxaban-Induced Anaphylaxis Secondary to Ingestion of Rivaroxaban and Nimesulide Without Cross-Reactivity to Dabigatran – A Case Report J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-09 Gediminas Gumbis, Inga Česnavičiūtė, Gabija Didžiokaitė, Daiva Gegeckienė, Violeta Kvedarienė
Abstract: Here, we describe a case of anaphylaxis secondary to rivaroxaban in a 61-year-old woman 24 hours after orthopedic surgery. 10– 15 minutes after ingestion of rivaroxaban and nimesulide, the patient’s palms started itching, her face and lips swelled, her face flushed, she developed shortness of breath and subsequently lost consciousness. Serum tryptase levels at the time of the anaphylactic
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Association Between Adult Antibiotic Use, Microbial Dysbiosis and Atopic Conditions – A Systematic Review J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-06 Wan Zhen Janice Ng, James van Hasselt, Bhumika Aggarwal, Anand Manoharan
Background: Strong associations between early antibiotic exposure and increased risk of childhood allergies have been established. Antibiotics have the potential to induce microbial dysbiosis that may be linked to allergic conditions. This review examines the limited available evidence on the associations between adult antibiotic use, microbial dysbiosis and atopic conditions. Methods: A systematic
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Global Burden of Asthma, and Its Impact on Specific Subgroups: Nasal Polyps, Allergic Rhinitis, Severe Asthma, Eosinophilic Asthma J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-06 Adrian Paul J Rabe, Wei Jie Loke, Khushboo Gurjar, Allison Brackley, Don Eliseo Lucero-Prisno III
Background: The complex nature of asthma has resulted in a poor understanding of its epidemiology, particularly in low-and middle-income countries (LMIC). Clinical subgroups, such as patients with severe asthma, eosinophilic asthma, allergic rhinitis, or nasal polyps, experience additional barriers to care. Methods: Prevalence estimates for asthma and key clinical subgroups were extracted from the
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Self-Management in Allergic Rhinitis: Strategies, Outcomes and Integration into Clinical Care J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-05 Giorgio Ciprandi
Abstract: Allergic rhinitis (AR) is a common disease, characterized by typical symptoms and type 2 inflammation. Standard treatment is usually effective and safe, and most medications are available as over-the-counter (OTC). Therefore, AR patients, mostly at the AR onset or if symptoms are mild, prefer to manage symptoms themselves. However, self-management could be associated with problems, including
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Music Therapy in Pediatric Asthma: A Short Review J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-04 Dandan Zhang, Xiaoxuan Yu, Qian Lin, Ying Xia, Guyi Wang, Jianhua Zhang, Yanyi Yang
Abstract: Music therapy (MT) is a common modality that performs a complementary and integrative role along with standard treatments for many pediatric diseases. This article briefly reviewed the effects of MT on children aged 5– 11 years old and adolescents with asthma from previous studies, specified its functional target towards asthma symptoms, and sorted out the design and investigation of selected
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Prevalence of Poorly Controlled Asthma and Factors Associated with Specialist Referral in Those with Poorly Controlled Asthma in a Paediatric Asthma Population J. Asthma Allergy (IF 3.2) Pub Date : 2023-10-03 Constantinos Kallis, Ann Morgan, Louise Fleming, Jennifer K Quint
Background: Significant morbidity and mortality are associated with poor asthma control. The aim of this study was to determine factors associated with poor control and referral to specialist secondary care services. Methods: We used primary care data from the Clinical Practice Research Datalink Aurum (CPRD) linked with Hospital Episode Statistics (HES) records from 1st January 2007 to 31st December
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Management of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the Pan-Arab Region: Consensus Recommendations from a Multidisciplinary Expert Working Group J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-29 Osama Marglani, Rashid Al Abri, Mona Al Ahmad, Saad Alsaleh, Mohamed Abuzakouk, Reda Kamel
Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic and often debilitating inflammatory condition of the nasal and paranasal tissues. An expert panel of specialists from the Gulf region (the Kingdom of Saudi Arabia, Kuwait, Oman and the United Arab Emirates) and from Egypt gathered to evaluate existing guidance and develop regional guidance on the management of CRSwNP through a
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Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR [Corrigendum] J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-27 Tanya M Laidlaw, Andrew Menzies-Gow, Scott Caveney, Joseph K Han, Nicole Martin, Elliot Israel, Jason K Lee, Jean-Pierre Llanos, Neil Martin, Ayman Megally, Bhavini Parikh, Sylvia Vong, Tobias Welte, Jonathan Corren
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Asthma and COVID-19 Outcomes: A Prospective Study in a Large Health Care Delivery System J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-26 Lindsay K Finkas, Navneet Ramesh, Lawrence S Block, Bing Q Yu, Mei-Tsung Lee, Meng Lu, Jacek Skarbinski, Carlos Iribarren
Introduction: Previous studies on the outcomes of asthma and COVID-19 have shown inconsistent results. This study aimed to elucidate the association between asthma and COVID-19 outcomes. Methods: We conducted a prospective study with a large health plan to compare the incidence of COVID-19 infection, hospitalization and ICU admission in a cohort of 41,282 patients with asthma and a 1:1 age-, sex-,
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Epidemiology and Immunopathogenesis of Virus Associated Asthma Exacerbations J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-26 Agamemnon Bakakos, Zoi Sotiropoulou, Angelos Vontetsianos, Stavroula Zaneli, Andriana I Papaioannou, Petros Bakakos
Abstract: Asthma is a common airway disease, affecting millions of people worldwide. Although most asthma patients experience mild symptoms, it is characterized by variable airflow limitation, which can occasionally become life threatening in the case of a severe exacerbation. The commonest triggers of asthma exacerbations in both children and adults are viral infections. In this review article, we
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The Effects of a Healthy Diet on Asthma and Wheezing in Children and Adolescents: A Systematic Review and Meta-Analysis J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-25 Jin Zhang, Mengyang He, Qiduo Yu, Fei Xiao, Yongming Zhang, Chaoyang Liang
Background: Asthma is a public health problem requiring focused attention. This study aimed to systematically evaluate the association between dietary structure and asthma or wheezing in children. Methods: The study protocol of this meta-analysis has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) with the registration code CRD42023390191. A total of 8397
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Chronic Diarrhea with Villous Blunting of the Small Intestine Under Capsule Endoscopy in Common Variable Immunodeficiency and X-Linked Agammaglobulinemia: A Case Series J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-22 Feihong Deng, Hanyu Wang, Xuehong Wang
Introduction: Primary immunodeficiencies (PIDs) are a heterogeneous group of disorders, common variable immunodeficiency disorder (CVID) and X-linked agammaglobulinemia (XLA) are PIDs related to B-cell defect, characterized by reduced levels of immunoglobulins and immune dysregulation. Infections are the most common clinical manifestations, while underlying autoimmune and inflammatory conditions are
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Online Survey to Investigate Asthma Medication Prescription and Adherence from the Perspective of Patients and Healthcare Practitioners in England J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-18 Xiubin Zhang, Jennifer K Quint
Background: High short-acting β2-agonist (SABA) use and/or inhaled corticosteroid (ICS) underuse are common and are associated with poor asthma outcomes. This study explored patients’ and healthcare practitioners’ (HCPs’) perspectives to contextualize asthma treatment patterns observed in real-world studies. Methods: Data were collected using online surveys from HCPs and people with asthma (≥ 18 years
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The Assessment of TLR1 Gene Polymorphism Association with the Risk of Allergic Rhinitis in the Chinese Han Population from Northern China J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-18 Hui Han, Penggang Lian, Haiyuan Chen, Bilal Haider Shamsi, Yonglin Liu, Yongliang Niu
Background: Environmental factors and genetic predisposition can influence the occurrence and development of AR. Toll-like receptor 1 (TLR1) belongs to the TLR receptor family, which plays a fundamental role in the activation of innate immunity. This study aimed to explore the association between TLR1 genetic loci and AR susceptibility in the Han Chinese from northern China. Methods: Genotyping of
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Yellow Urticaria: A Systematic Review J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-08 Kanokvalai Kulthanan, Tawesak Tanwandee, Leena Chularojanamontri, Waratchaya Panjapakkul, Phuwakorn Saengthong-aram
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Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-07 Jinyi Wan, Jingjing Song, Qingqing Lv, Hui Zhang, Qiangwei Xiang, Huan Dai, Hang Zheng, Xixi Lin, Weixi Zhang
Purpose: Recent studies had shown that gut microbiota played a significant role in the development of the immune system and may affect the course of airway allergic disease. We conducted this study to determine unique gut microbial associated with allergic disease in children by shotgun gene sequencing. Methods: We collected fecal samples from children with allergic asthma (n = 23) and allergic rhinitis
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Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study J. Asthma Allergy (IF 3.2) Pub Date : 2023-09-06 Yunlei Ma, Hanjun Zhao, Yinghao Su
Purpose: The evidence for a causal relationship between high-level ozone (O3) exposure and acute exacerbation of asthma among adults is limited, and the conclusions are less definitive. Patients and methods: Here we collected the daily data on asthma cases, O3 exposure, and meteorological factors from 2010 to 2016 in Shijiazhuang, China. We investigated the risk of asthma exacerbation associated with