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Effectiveness of Aspirin on Major COPD Outcomes: A Prevalent New-User Design Observational Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-03-14 Charles Khouri, Sophie Dell’Aniello, Pierre Ernst, Samy Suissa
Observational studies that have reported an association between aspirin use in chronic obstructive pulmonary disease (COPD) with reductions in mortality and COPD exacerbations were shown to be affe...
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Understanding the Gaps in the Reporting of COPD Exacerbations by Patients: A Review COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-29 Paul Jones, Ashraf Alzaabi, Alejandro Casas Herrera, Mehmet Polatli, Marcelo Fouad Rabahi, Arturo Cortes Telles, Bhumika Aggarwal, Sudeep Acharya, Abdelkader El Hasnaoui, Chris Compton
Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function, poor quality of life, loss of exercise capacity, risk of serious cardiovascular events, hosp...
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Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-29 He-Ping Xu, Huan Niu, Hong Wang, Jie Lin, Jin-Jian Yao
Chronic obstructive pulmonary disease (COPD) is a common chronic disease characterized by airflow obstruction, which seriously threatens people’s health. The COPD mouse model was established with c...
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Beyond Spirometry: Linking Wasted Ventilation to Exertional Dyspnea in the Initial Stages of COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-13 J. Alberto Neder, Giles Santyr, Brandon Zanette, Miranda Kirby, Marina Pourafkari, Matthew D. James, Sandra G. Vincent, Carrie Ferguson, Chu-Yi Wang, Nicolle J. Domnik, Devin B. Phillips, Janos Porszasz, William W. Stringer, Denis E. O’Donnell
Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease (COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non-hypoxemic patients wi...
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Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-13 Tongyao Sun, Jun Wang, Min Zheng, Chengsen Cai, Jianjian Yu, Lina Fu, Lei Duan
Background: Clinical studies have shown that the onset and exacerbation of chronic obstructive pulmonary disease (COPD) are related to obesity and dietary behaviours, but the genetic relationship b...
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Impressions and Perceptions of a Smartphone and Smartwatch Self-Management Tool for Patients With COPD: A Qualitative Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-13 Robert Wu, Maryann Calligan, Tanya Son, Harshmeet Rakhra, Eyal de Lara, Alex Mariakakis, Andrea S. Gershon
Patients with chronic obstructive pulmonary disease (COPD) often do not seek care until they experience an exacerbation. Improving self-management for these patients may increase health-related qua...
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Guidelines for the Pharmacologic Treatment of COPD 2023: Canada versus GOLD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-08 Samy Suissa
Published in COPD: Journal of Chronic Obstructive Pulmonary Disease (Vol. 21, No. 1, 2024)
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The Role of Bioactive Small Molecules in COPD Pathogenesis COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-08 Sha Liao, Yahong Chen
Chronic obstructive pulmonary disease (COPD) is recognized as a predominant contributor to mortality worldwide, which causes significant burdens to both society and individuals. Given the limited t...
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Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-02-05 Won-Dong Kim, Don D. Sin
Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question th...
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It Is Smart to Set Treatment Goals, But Are Set Treatment Goals SMART? A Qualitative Assessment of Goals Described in the Assessment of the Burden of COPD Tool COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2024-01-05 M. Voorhaar, O. C. P. van Schayck, B. Winkens, J. W. M. Muris, A. H. M. Slok
The Assessment of the Burden of COPD (ABC) tool facilitates shared decision-making and goal setting to develop a personalized care plan. In a previous trial (RCT), the ABC tool was found to have a ...
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Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-11-27 Chuanxin Yang, Libing Deng, Fang Bao, Hui Jiang, Long Zhang
Chronic obstructive pulmonary disease (COPD) is a difficult-to-cure disease that mainly affects the respiratory system. Inhaled anesthetic drug such as sevoflurane plays a controversial role in COP...
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The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-31 Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie
Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic variation in the ris...
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The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-31 Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie
Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic variation in the ris...
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Development and Validation of Prediction Models for Exacerbation, Frequent Exacerbations and Severe Exacerbations of Chronic Obstructive Pulmonary Disease: A Registry Study in North China COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-23 Yuyan Zhou, Siqi He, Wanying Wang, Xiaoyue Wang, Xiaoting Chen, Xiaoning Bu, Deshuai Li
In COPD patients, exacerbation has a detrimental influence on the quality of life, disease progression and socioeconomic burden. This study aimed to develop and validate models to predict exacerbat...
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Development and Validation of Prediction Models for Exacerbation, Frequent Exacerbations and Severe Exacerbations of Chronic Obstructive Pulmonary Disease: A Registry Study in North China COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-23 Yuyan Zhou, Siqi He, Wanying Wang, Xiaoyue Wang, Xiaoting Chen, Xiaoning Bu, Deshuai Li
In COPD patients, exacerbation has a detrimental influence on the quality of life, disease progression and socioeconomic burden. This study aimed to develop and validate models to predict exacerbat...
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Minimal-Resource Home Exercise Program Improves Activities of Daily Living, Perceived Health Status, and Shortness of Breath in Individuals with COPD Stages GOLD II to IV COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-18 Vanessa Joaquim Ribeiro Moço, Aline Almeida Gulart, Agnaldo José Lopes, Arthur de Sá Ferreira, Luis Felipe da Fonseca Reis
Home exercises (HE) with minimal resources seem to be useful in individuals with COPD. The objective was to evaluate the effects of HE, on activities of daily living (ADL), dyspnea, on the health s...
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Minimal-Resource Home Exercise Program Improves Activities of Daily Living, Perceived Health Status, and Shortness of Breath in Individuals with COPD Stages GOLD II to IV COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-18 Vanessa Joaquim Ribeiro Moço, Aline Almeida Gulart, Agnaldo José Lopes, Arthur de Sá Ferreira, Luis Felipe da Fonseca Reis
Home exercises (HE) with minimal resources seem to be useful in individuals with COPD. The objective was to evaluate the effects of HE, on activities of daily living (ADL), dyspnea, on the health s...
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Integrative Analyses of Mendelian Randomization and Transcriptomic Data Reveal No Association between Leptin and Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-09 Ao Zhang, Suyan Tian
As a key adipokine, leptin has been extensively investigated for its potential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, concordant conclusions have not bee...
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Integrative Analyses of Mendelian Randomization and Transcriptomic Data Reveal No Association between Leptin and Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-10-09 Ao Zhang, Suyan Tian
As a key adipokine, leptin has been extensively investigated for its potential role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, concordant conclusions have not bee...
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Chest MRI and CT Predictors of 10-Year All-Cause Mortality in COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-09-22 Maksym Sharma, Paulina V. Wyszkiewicz, Alexander M. Matheson, David G. McCormack, Grace Parraga
Pulmonary imaging measurements using magnetic resonance imaging (MRI) and computed tomography (CT) have the potential to deepen our understanding of chronic obstructive pulmonary disease (COPD) by ...
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Chest MRI and CT Predictors of 10-Year All-Cause Mortality in COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-09-22 Maksym Sharma, Paulina V. Wyszkiewicz, Alexander M. Matheson, David G. McCormack, Grace Parraga
Pulmonary imaging measurements using magnetic resonance imaging (MRI) and computed tomography (CT) have the potential to deepen our understanding of chronic obstructive pulmonary disease (COPD) by ...
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Governmental Non-Pharmaceutical Interventions during the COVID-19 Pandemic and the COPD Exacerbation and Respiratory Infection Rate in Patients with Alpha-1 Antitrypsin Deficiency COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-09-04 Naomi Nanke Kappe, Noga Alagem, Naveh Tov, Jan Stolk
Abstract During the COVID-19 pandemic the number of hospital admissions due to chronic obstructive pulmonary disease (COPD) exacerbations was significantly reduced. The reason for this decline is not fully understood. Governmental non-pharmaceutical interventions (NPI’s), an increase in community treated exacerbations, or healthcare avoidance by patients, are potential reasons. For the current study
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Governmental Non-Pharmaceutical Interventions during the COVID-19 Pandemic and the COPD Exacerbation and Respiratory Infection Rate in Patients with Alpha-1 Antitrypsin Deficiency COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-09-04 Naomi Nanke Kappe, Noga Alagem, Naveh Tov, Jan Stolk
Abstract During the COVID-19 pandemic the number of hospital admissions due to chronic obstructive pulmonary disease (COPD) exacerbations was significantly reduced. The reason for this decline is not fully understood. Governmental non-pharmaceutical interventions (NPI’s), an increase in community treated exacerbations, or healthcare avoidance by patients, are potential reasons. For the current study
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Statins and Mortality in COPD: A Methodological Review of Observational Studies COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-08-09 Naheemot Olaoluwa Sule, Samy Suissa
Abstract Randomized controlled trials and observational studies have reported conflicting results on the potential beneficial effects of statins on mortality in patients with chronic obstructive pulmonary disease (COPD). We performed a systematic search of the literature to review all observational studies reporting relative risks of death with statin use in COPD, focusing on potential sources of bias
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Development of Multivariable Prediction Models for the Identification of Patients Admitted to Hospital with an Exacerbation of COPD and the Prediction of Risk of Readmission: A Retrospective Cohort Study using Electronic Medical Record Data COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-08-09 Reza Fakhraei, John Matelski, Andrea Gershon, Tetyana Kendzerska, Lauren Lapointe-Shaw, Lanujan Kaneswaran, Robert Wu
Abstract Background Approximately 20% of patients who are discharged from hospital for an acute exacerbation of COPD (AECOPD) are readmitted within 30 days. To reduce this, it is important both to identify all individuals admitted with AECOPD and to predict those who are at higher risk for readmission. Objectives To develop two clinical prediction models using data available in electronic medical records:
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Statins and Mortality in COPD: A Methodological Review of Observational Studies COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-08-09 Naheemot Olaoluwa Sule, Samy Suissa
Abstract Randomized controlled trials and observational studies have reported conflicting results on the potential beneficial effects of statins on mortality in patients with chronic obstructive pulmonary disease (COPD). We performed a systematic search of the literature to review all observational studies reporting relative risks of death with statin use in COPD, focusing on potential sources of bias
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Development of Multivariable Prediction Models for the Identification of Patients Admitted to Hospital with an Exacerbation of COPD and the Prediction of Risk of Readmission: A Retrospective Cohort Study using Electronic Medical Record Data COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-08-09 Reza Fakhraei, John Matelski, Andrea Gershon, Tetyana Kendzerska, Lauren Lapointe-Shaw, Lanujan Kaneswaran, Robert Wu
Abstract Background Approximately 20% of patients who are discharged from hospital for an acute exacerbation of COPD (AECOPD) are readmitted within 30 days. To reduce this, it is important both to identify all individuals admitted with AECOPD and to predict those who are at higher risk for readmission. Objectives To develop two clinical prediction models using data available in electronic medical records:
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Facilitators and Barriers of Adherence to Multi-Disease Exacerbation Action Plans in COPD Patients – A Qualitative Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-28 J. Schrijver, T. Effing, M. Brusse-Keizer, J. van der Palen, P. van der Valk, A. Lenferink
Abstract Whereas exacerbation action plans to self-manage Chronic Obstructive Pulmonary Disease (COPD) significantly improve health outcomes, patients’ adherence to those action plans is often poor. This study aimed to identify facilitators and barriers of adherence to tailored multi-disease exacerbation action plans. We also explored patients’ perspectives toward disease management roles. Individual
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Facilitators and Barriers of Adherence to Multi-Disease Exacerbation Action Plans in COPD Patients – A Qualitative Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-28 J. Schrijver, T. Effing, M. Brusse-Keizer, J. van der Palen, P. van der Valk, A. Lenferink
Abstract Whereas exacerbation action plans to self-manage Chronic Obstructive Pulmonary Disease (COPD) significantly improve health outcomes, patients’ adherence to those action plans is often poor. This study aimed to identify facilitators and barriers of adherence to tailored multi-disease exacerbation action plans. We also explored patients’ perspectives toward disease management roles. Individual
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Body Composition, Physical Function and Exercise Capacity in Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-27 Christa M. Todoroff, Michael J. Berry
Abstract Current literature yields unequivocal results regarding the effect of body composition on physical function in patients with chronic obstructive pulmonary disease and disproportionately includes a majority of males. The purpose of this study was to determine whether specific body composition measures are significantly associated with physical function and exercise capacity in patients with
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Body Composition, Physical Function and Exercise Capacity in Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-27 Christa M. Todoroff, Michael J. Berry
Abstract Current literature yields unequivocal results regarding the effect of body composition on physical function in patients with chronic obstructive pulmonary disease and disproportionately includes a majority of males. The purpose of this study was to determine whether specific body composition measures are significantly associated with physical function and exercise capacity in patients with
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Sleep Hypoventilation is Common in Diurnal Normocapnic COPD Patients with Severe or Very Severe Obstruction and is Not Associated with Body Mass Index COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-24 Safir Zewari, Bram van den Borst, Michel van den Heuvel, Frank van den Elshout, Manu Sastry, Petra Vos
Abstract Sleep hypoventilation (SH) is common in COPD patients with diurnal hypercapnia, however there are little data on the presence of SH in COPD patients with diurnal normocapnia. In this study the prevalence of SH in stable normocapnic COPD patients with severe or very severe obstruction (GOLD stages III and IV) was evaluated across body mass index (BMI) classes and associations between SH and
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Sleep Hypoventilation is Common in Diurnal Normocapnic COPD Patients with Severe or Very Severe Obstruction and is Not Associated with Body Mass Index COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-24 Safir Zewari, Bram van den Borst, Michel van den Heuvel, Frank van den Elshout, Manu Sastry, Petra Vos
Abstract Sleep hypoventilation (SH) is common in COPD patients with diurnal hypercapnia, however there are little data on the presence of SH in COPD patients with diurnal normocapnia. In this study the prevalence of SH in stable normocapnic COPD patients with severe or very severe obstruction (GOLD stages III and IV) was evaluated across body mass index (BMI) classes and associations between SH and
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The Influence of Breathing Exercises on Regional Ventilation in Healthy and Patients with Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-21 Lin Yang, Ke Zhao, Zhijun Gao, Feng Fu, Hang Wang, Chunchen Wang, Jing Dai, Yang Liu, Yilong Qin, Meng Dai, Xinsheng Cao, Zhanqi Zhao
Abstract We hypothesized that the respiratory exercises have uniform effects on ventilation in healthy subjects but the effects varied in patients with chronic obstructive pulmonary disease (COPD). In this study, a total of 30 healthy volunteers and 9 patients with COPD were included. Data were recorded continuously during (1) diaphragmatic breathing; (2) pursed lip breathing with full inhalation;
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The Influence of Breathing Exercises on Regional Ventilation in Healthy and Patients with Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-21 Lin Yang, Ke Zhao, Zhijun Gao, Feng Fu, Hang Wang, Chunchen Wang, Jing Dai, Yang Liu, Yilong Qin, Meng Dai, Xinsheng Cao, Zhanqi Zhao
Abstract We hypothesized that the respiratory exercises have uniform effects on ventilation in healthy subjects but the effects varied in patients with chronic obstructive pulmonary disease (COPD). In this study, a total of 30 healthy volunteers and 9 patients with COPD were included. Data were recorded continuously during (1) diaphragmatic breathing; (2) pursed lip breathing with full inhalation;
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Sex-Specific Genetic Determinants of Asthma-COPD Phenotype and COPD in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-19 Ugochukwu Odimba, Ambikaipakan Senthilselvan, Jamie Farrell, Zhiwei Gao
Abstract The etiology of sex differences in the risk of asthma-COPD phenotype and COPD is still not completely understood. Genetic and environmental risk factors are commonly believed to play an important role. This study aims to identify sex-specific genetic markers associated with asthma-COPD phenotype and COPD using the Canadian Longitudinal Study on Aging (CLSA) Baseline Comprehensive and Genomic
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Sex-Specific Genetic Determinants of Asthma-COPD Phenotype and COPD in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-19 Ugochukwu Odimba, Ambikaipakan Senthilselvan, Jamie Farrell, Zhiwei Gao
Abstract The etiology of sex differences in the risk of asthma-COPD phenotype and COPD is still not completely understood. Genetic and environmental risk factors are commonly believed to play an important role. This study aims to identify sex-specific genetic markers associated with asthma-COPD phenotype and COPD using the Canadian Longitudinal Study on Aging (CLSA) Baseline Comprehensive and Genomic
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Development of a Communication Tool between Patients and Physicians for Recognizing COPD Exacerbations in Japan COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-13 Paul Jones, Osamu Hataji, Yoshimi Suzukamo, Bruce Crawford, Yoko Sakai, Takeo Ishii, Keiko Sato, Eri Sasaki, Kenichi Hashimoto, Toru Oga
Abstract In Japan, exacerbations are underreported compared with other countries, possibly due in part to a failure to recognize them. This study aimed to create a simple chronic obstructive pulmonary disease (COPD) Exacerbation Recognition Tool (CERT-J) specifically for Japanese patients. Patients ≥40 years with confirmed COPD or asthma-COPD overlap were included. Focus groups were held to identify
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Development of a Communication Tool between Patients and Physicians for Recognizing COPD Exacerbations in Japan COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-13 Paul Jones, Osamu Hataji, Yoshimi Suzukamo, Bruce Crawford, Yoko Sakai, Takeo Ishii, Keiko Sato, Eri Sasaki, Kenichi Hashimoto, Toru Oga
Abstract In Japan, exacerbations are underreported compared with other countries, possibly due in part to a failure to recognize them. This study aimed to create a simple chronic obstructive pulmonary disease (COPD) Exacerbation Recognition Tool (CERT-J) specifically for Japanese patients. Patients ≥40 years with confirmed COPD or asthma-COPD overlap were included. Focus groups were held to identify
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Development of a Diagnostic Nomogram to Predict CAP in Hospitalized Patients with AECOPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-05 Nafeisa Dilixiati, Mengyu Lian, Ziliang Hou, Jie Song, Jingjing Yang, Ruiyan Lin, Jinxiang Wang
Abstract The purpose of this study was to establish a nomogram for predicting community-acquired pneumonia (CAP) in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The retrospective cohort study included 1249 hospitalized patients with AECOPD between January 2012 and December 2019. The patients were divided into pneumonia-complicating AECOPD (pAECOPD)
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Reduced Total Airway Count and Airway Wall Tapering after Three-Years in Ex-Smokers COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-03 Paulina V. Wyszkiewicz, Maksym Sharma, Vedanth Desaigoudar, Ian A. Cunningham, David G. McCormack, Mohamed A. Abdelrazek, Miranda Kirby, Grace Parraga
Abstract Computed tomography (CT) total-airway-count (TAC) and airway wall-thickness differ across chronic obstructive pulmonary disease (COPD) severities, but longitudinal insights are lacking. The aim of this study was to evaluate longitudinal CT airway measurements over three-years in ex-smokers. In this prospective convenience sample study, ex-smokers with (n = 50; 13 female; age = 70 ± 9 years;
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Current Perspectives on Biological Therapy for COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-03 Ambedkar Kumar Yadav, Wenhua Gu, Tongyangzi Zhang, Xianghuai Xu, Li Yu
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic, complex, and heterogeneous condition with significant mortality, morbidity, and socioeconomic burden. Given the heterogeneity, the current management of COPD, which mainly relies on bronchodilators and corticosteroids, cannot consider all COPD populations. Moreover, the present treatment modalities are directed at minimizing symptoms
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Reduced Total Airway Count and Airway Wall Tapering after Three-Years in Ex-Smokers COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-03 Paulina V. Wyszkiewicz, Maksym Sharma, Vedanth Desaigoudar, Ian A. Cunningham, David G. McCormack, Mohamed A. Abdelrazek, Miranda Kirby, Grace Parraga
Abstract Computed tomography (CT) total-airway-count (TAC) and airway wall-thickness differ across chronic obstructive pulmonary disease (COPD) severities, but longitudinal insights are lacking. The aim of this study was to evaluate longitudinal CT airway measurements over three-years in ex-smokers. In this prospective convenience sample study, ex-smokers with (n = 50; 13 female; age = 70 ± 9 years;
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Current Perspectives on Biological Therapy for COPD COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-07-03 Ambedkar Kumar Yadav, Wenhua Gu, Tongyangzi Zhang, Xianghuai Xu, Li Yu
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic, complex, and heterogeneous condition with significant mortality, morbidity, and socioeconomic burden. Given the heterogeneity, the current management of COPD, which mainly relies on bronchodilators and corticosteroids, cannot consider all COPD populations. Moreover, the present treatment modalities are directed at minimizing symptoms
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Prognostic Value of Serum Cholinesterase Levels for In-Hospital Mortality among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-24 Zhixiang Chen, Lei Zha, Guohong Feng, Qian An, Fei Shi, Jingjing Xu, Qiancheng Xu, Huimin Xia, Milan Zhang, Lu Li
Abstract Cholinesterase (ChE) is associated with the pathogenesis of chronic obstructive pulmonary disease (COPD), including chronic airway inflammation and oxidation/antioxidant imbalance. However, the relationship between serum ChE levels and survival outcomes of patients hospitalized with acute exacerbations of COPD (AECOPD) is unknown. In this retrospective single-center study, we investigated
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Prognostic Value of Serum Cholinesterase Levels for In-Hospital Mortality among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-24 Zhixiang Chen, Lei Zha, Guohong Feng, Qian An, Fei Shi, Jingjing Xu, Qiancheng Xu, Huimin Xia, Milan Zhang, Lu Li
Abstract Cholinesterase (ChE) is associated with the pathogenesis of chronic obstructive pulmonary disease (COPD), including chronic airway inflammation and oxidation/antioxidant imbalance. However, the relationship between serum ChE levels and survival outcomes of patients hospitalized with acute exacerbations of COPD (AECOPD) is unknown. In this retrospective single-center study, we investigated
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The Relationship between Physical Activity, Depression and Anxiety in People with COPD: A Systematic Review and Meta-analyses COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-15 Anne-Marie Selzler, Cindy Ellerton, Lauren Ellerton, Razanne Habash, Erica Nekolaichuk, Roger Goldstein, Dina Brooks
Abstract Depression and anxiety are related to physical activity among people with chronic obstructive pulmonary disease (COPD), although the strength and direction of the reported relationships are inconsistent. This study systematically synthesized the relationships between physical activity and i) depression and ii) anxiety in people with COPD. Physical activity measurement type (objective, self-report)
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The Relationship between Physical Activity, Depression and Anxiety in People with COPD: A Systematic Review and Meta-analyses COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-15 Anne-Marie Selzler, Cindy Ellerton, Lauren Ellerton, Razanne Habash, Erica Nekolaichuk, Roger Goldstein, Dina Brooks
Abstract Depression and anxiety are related to physical activity among people with chronic obstructive pulmonary disease (COPD), although the strength and direction of the reported relationships are inconsistent. This study systematically synthesized the relationships between physical activity and i) depression and ii) anxiety in people with COPD. Physical activity measurement type (objective, self-report)
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Do Functional Tests Estimate Physical Activity in COPD? COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-11 Natielly Soares Correia, Joice Mara de Oliveira, Lorena Paltanin Schneider, Andrea Akemi Morita, Fabio Pitta, Karina Couto Furlanetto
Abstract The association between physical activity in daily life (PADL) and simple functional tests is not yet clearly understood in subjects with chronic obstructive pulmonary disease (COPD). Therefore, the aim of this study was to investigate the association of two functional tests (Sit-to-Stand test [STS] and the 4-Metre Gait Speed test [4MGS]) with PADL, as well as to identify whether these tests
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Do Functional Tests Estimate Physical Activity in COPD? COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-05-11 Natielly Soares Correia, Joice Mara de Oliveira, Lorena Paltanin Schneider, Andrea Akemi Morita, Fabio Pitta, Karina Couto Furlanetto
Abstract The association between physical activity in daily life (PADL) and simple functional tests is not yet clearly understood in subjects with chronic obstructive pulmonary disease (COPD). Therefore, the aim of this study was to investigate the association of two functional tests (Sit-to-Stand test [STS] and the 4-Metre Gait Speed test [4MGS]) with PADL, as well as to identify whether these tests
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Incidence and Healthcare Burden of Pertussis among Older Adults with and without Pre-Existing Chronic Obstructive Pulmonary Disease or Asthma in South Korea COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-24 Jing Chen, Ju-Young Shin, Hyungwoo Kim, Ju Hwan Kim, Ahhyung Choi, Hee Jin Cheong, Yeon-Mok Oh, Adrienne Guignard, Sumitra Shantakumar
Abstract A retrospective cohort study was conducted to examine trends in the incidence and burden of pertussis among adults ≥50 years in South Korea, with/without pre-existing chronic obstructive pulmonary disease (COPD) or asthma. The nationwide Health Insurance Review and Assessment Service (HIRA) database was used to identify patients ≥50 years diagnosed with pertussis (2009–2018). Mean annual incidence
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Incidence and Healthcare Burden of Pertussis among Older Adults with and without Pre-Existing Chronic Obstructive Pulmonary Disease or Asthma in South Korea COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-24 Jing Chen, Ju-Young Shin, Hyungwoo Kim, Ju Hwan Kim, Ahhyung Choi, Hee Jin Cheong, Yeon-Mok Oh, Adrienne Guignard, Sumitra Shantakumar
Abstract A retrospective cohort study was conducted to examine trends in the incidence and burden of pertussis among adults ≥50 years in South Korea, with/without pre-existing chronic obstructive pulmonary disease (COPD) or asthma. The nationwide Health Insurance Review and Assessment Service (HIRA) database was used to identify patients ≥50 years diagnosed with pertussis (2009–2018). Mean annual incidence
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COPD Assessment Test as a Screening Tool for Anxiety and Depression in Stable COPD Patients: A Feasibility Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-10 Meishan Liu, Yuna Li, Danfeng Yin, Ying Wang, Tingting Fu, Zhaomeng Zhu, Chunming Zheng, Kewu Huang
Abstract Anxiety and depression are common comorbidities in chronic obstructive pulmonary disease (COPD) patients but are often under-diagnosed. We aimed to assess the suitability of the COPD Assessment Test (CAT) in screening anxiety and depression in patients with COPD. Stable COPD patients from a cross-sectional observational study were assessed by CAT. Anxiety and depression were identified using
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Prevalence, Trend, and Risk Factors for Early Chronic Obstructive Pulmonary Disease: An Analysis of the Nationwide Population-Based Survey from 2010 to 2019 in South Korea COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-10 Taeyun Kim, Hyunji Choi, Ju-il Seo, Seung-Jin Kim, Ji-Eun Choi, Minsu Yun, Jihun Kang
Abstract This study aimed to evaluate the prevalence, trends, and risk factors of early chronic obstructive pulmonary disease (COPD) by using a nationally representative sample. The datasets of the Korea National Health and Nutrition Examination Survey 2010–2019 were used, where 80,860 individuals were identified; of these, 9,045 participants aged 40–49 years who underwent spirometry with no missing
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COPD Assessment Test as a Screening Tool for Anxiety and Depression in Stable COPD Patients: A Feasibility Study COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-10 Meishan Liu, Yuna Li, Danfeng Yin, Ying Wang, Tingting Fu, Zhaomeng Zhu, Chunming Zheng, Kewu Huang
Abstract Anxiety and depression are common comorbidities in chronic obstructive pulmonary disease (COPD) patients but are often under-diagnosed. We aimed to assess the suitability of the COPD Assessment Test (CAT) in screening anxiety and depression in patients with COPD. Stable COPD patients from a cross-sectional observational study were assessed by CAT. Anxiety and depression were identified using
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Prevalence, Trend, and Risk Factors for Early Chronic Obstructive Pulmonary Disease: An Analysis of the Nationwide Population-Based Survey from 2010 to 2019 in South Korea COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-04-10 Taeyun Kim, Hyunji Choi, Ju-il Seo, Seung-Jin Kim, Ji-Eun Choi, Minsu Yun, Jihun Kang
Abstract This study aimed to evaluate the prevalence, trends, and risk factors of early chronic obstructive pulmonary disease (COPD) by using a nationally representative sample. The datasets of the Korea National Health and Nutrition Examination Survey 2010–2019 were used, where 80,860 individuals were identified; of these, 9,045 participants aged 40–49 years who underwent spirometry with no missing
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Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-03-28 Amany F. Elbehairy, Sandra G. Vincent, Devin B. Phillips, Matthew D. James, Jenna Veugen, Grace Parraga, Denis E. O’Donnell, J. Alberto Neder
Abstract Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased ventilation (⩒E)-carbon dioxide output (⩒CO2) during exercise are frequent findings in dyspneic smokers with largely preserved FEV1. It remains unclear whether low DLCO and high ⩒E-⩒CO2 are mere reflections of alveolar destruction (i.e. emphysema) or impaired pulmonary perfusion in non-emphysematous tissue contributes
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Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-03-28 Amany F. Elbehairy, Sandra G. Vincent, Devin B. Phillips, Matthew D. James, Jenna Veugen, Grace Parraga, Denis E. O’Donnell, J. Alberto Neder
Abstract Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased ventilation (⩒E)-carbon dioxide output (⩒CO2) during exercise are frequent findings in dyspneic smokers with largely preserved FEV1. It remains unclear whether low DLCO and high ⩒E-⩒CO2 are mere reflections of alveolar destruction (i.e. emphysema) or impaired pulmonary perfusion in non-emphysematous tissue contributes
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LncRNA H19 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-181/PDCD4 Axis COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-03-21 Panpan Liu, Hongchang Gao, Yumeng Wang, Yujuan Li, Lei Zhao
Abstract Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year. Despite progress in the treatment of symptoms and prevention of acute exacerbations, few advances have been made to ameliorate disease progression or affect mortality. Exercise plays a positive role in the prevention and treatment of diaphragm dysfunction in COPD, and the changes in diaphragm
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LncRNA H19 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-181/PDCD4 Axis COPD J. Chronic Obstr. Pulm. Dis. (IF 2.2) Pub Date : 2023-03-21 Panpan Liu, Hongchang Gao, Yumeng Wang, Yujuan Li, Lei Zhao
Abstract Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year. Despite progress in the treatment of symptoms and prevention of acute exacerbations, few advances have been made to ameliorate disease progression or affect mortality. Exercise plays a positive role in the prevention and treatment of diaphragm dysfunction in COPD, and the changes in diaphragm