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The effects of upper limb exercise training on upper limb muscle strength in people with chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-05-10 Christos Karagiannis, Christos Savva, Vasileios Korakakis, George Ploutarchou, Tonia Adamide, Andreas Georgiou, Theodoros Xanthos
Background:Upper limb (UL) muscle dysfunction is a common extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD). UL muscle dysfunction is associated with muscle weakness, dys...
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Determination of patient-specific airway stent fit using novel 3D reconstruction measurement techniques: a 4-year follow-up of a patient Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-05-09 Prince Ntiamoah, Thomas R. Gildea, Adrianna Baiera
Managing complex benign airway disease is a major challenge in interventional pulmonology. With the introduction of additive manufacturing in the medical field, patient-specific (PS) implants are a...
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The therapeutic potential of quercetin for cigarette smoking–induced chronic obstructive pulmonary disease: a narrative review Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-05-08 Kaixi Ding, Wei Jiang, Wenling Zhan, Chunping Xiong, Jieling Chen, Yu Wang, Huanan Jia, Ming Lei
Quercetin is a flavonoid with antioxidant and anti-inflammatory properties. Quercetin has potentially beneficial therapeutic effects for several diseases, including cigarette smoking–induced chroni...
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Role of clinical biomarkers in predicting the effectiveness of omalizumab Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-05-06 Qing Zhang, Chunxiao Li, Jingxuan Wan, Mengyuan Zhang, Ying Nong, Jiangtao Lin
Objective:To explore whether baseline clinical biomarkers and characteristics can be used to predict the responsiveness of omalizumab.Methods:We retrospectively analyzed a cohort of patients with s...
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Telemedicine in pulmonary rehabilitation – benefits of a telerehabilitation program in post-COVID-19 patients: a controlled quasi-experimental study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-29 Marta de la Plaza San Frutos, Vanesa Abuín Porras, María Blanco Morales, María García Arrabé, Cecilia Estrada Barranco, Margarita Rubio Alonso
Introduction:COVID-19 pandemic has challenged healthcare systems worldwide. The aim of this study was to assess the results of a Respiratory Telerehabilitation Program implemented to patients post-...
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The role of prone positioning in patients with SARS-CoV-2-related respiratory failure in non–intensive care unit Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-27 Mara Graziani, Greta Barbieri, Giorgio Maraziti, Marco Falcone, Anna Fiaccadori, Francesco Corradi, Lorenzo Ghiadoni, Katarzyna Satula, Ghislaine Noumi, Cecilia Becattini
Background:Prone positioning (PP) is an established and commonly used lung recruitment method for intubated patients with severe acute respiratory distress syndrome, with potential benefits in clin...
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Systematic review and meta-analysis of mesenchymal stromal/stem cells as strategical means for the treatment of COVID-19 Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-27 Hannah Taufiq, Kamal Shaik Fakiruddin, Umaiya Muzaffar, Moon Nian Lim, Syahnaz Rusli, Nor Rizan Kamaluddin, Ezalia Esa, Syahril Abdullah
Background:In coronavirus disease 2019 (COVID-19) patients, elevated levels of inflammatory cytokines from over stimulation of immune cells have become a concern due to the potential outburst of cy...
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Heterogeneity of asthma–chronic obstructive pulmonary disease (COPD) overlap from a cohort of patients with severe asthma and COPD Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-25 Joon Young Choi, Chin Kook Rhee, Kwang Ha Yoo, Ki-Suck Jung, Jae Ha Lee, Hyoung Kyu Yoon, Seung Won Ra, Myung Goo Lee, Yong Suk Jo
Background:A considerable proportion of patients have features of both asthma and chronic obstructive pulmonary disease (COPD) simultaneously, called asthma–COPD overlap (ACO).Objectives:The aim of...
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Prevalence, associated factors, and clinical consequences of metabolic syndrome in chronic obstructive pulmonary disease patients: a 5-year prospective observational study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-22 Warangkana Keeratichananont, Punchalee Kaenmuang, Sarayut Lucien Geater, Premanan Manoret, Banthita Thanapattaraborisuth
Background:Chronic obstructive pulmonary disease (COPD) is characterized by multiple systemic comorbidities, not only airflow limitation. Metabolic syndrome (MetS) is a common comorbidity. Patients...
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Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-20 Mengru Zhang, Alyn H. Morice, Fengli Si, Li Zhang, Qiang Chen, Shengyuan Wang, Yiqing Zhu, Xianghuai Xu, Li Yu, Zhongmin Qiu
Background:The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy.Objectives:We summarized the outcomes of the cu...
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Long-term home mechanical ventilation using a noninvasive ventilator via tracheotomy in patients with myasthenia gravis: a case report and literature review Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-19 Yanbing Liu, Tao Li, Lei Shi
Neuromuscular diseases (NMD) are indications for long-term home mechanical ventilation (HMV). Noninvasive ventilation is preferred to HMV. However, invasive mechanical ventilation (IMV) is more app...
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Exacerbation in patients with stable COPD in China: analysis of a prospective, 52-week, nationwide, observational cohort study (REAL) Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-19 Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Yahong Chen, Wenhua Jian, Chen Wang
Background:Chronic obstructive pulmonary disease (COPD) management in China is inadequate and there is a need to improve care and outcomes for patients nationwide.Objectives:The REAL study was desi...
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Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-19 Zhu-Quan Su, Ming-Lu Zhong, Ming-Yue Fan, Wan-Yuan Rao, Zi-Qing Zhou, Yu Chen, Xiao-Bo Chen, Chun-Li Tang, Chang-Hao Zhong, Shi-Yue Li
Background:A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway rem...
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Anti-fibrotic therapy and lung transplant outcomes in patients with idiopathic pulmonary fibrosis Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-19 Todd L. Astor, Hilary J. Goldberg, Laurie D. Snyder, Andrew Courtwright, Ramsey Hachem, Tahuanty Pena, Lorenzo Zaffiri, Gerard J. Criner, Marie M. Budev, Tany Thaniyavarn, Thomas B. Leonard, Shaun Bender, Aliaa Barakat, Janis L. Breeze, Peter LaCamera
Background:It is unclear whether continuing anti-fibrotic therapy until the time of lung transplant increases the risk of complications in patients with idiopathic pulmonary fibrosis.Objectives:To ...
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A prospective study on the long-term storage of sputum and the recovery of nontuberculous mycobacteria Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-17 Byoung Soo Kwon, Jeong Su Park, Jung-A Shin, Eun Sun Kim, Sung Yoon Lim, Myung Jin Song, Yeon-Wook Kim, Hyung-Jun Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Choon-Taek Lee, Jae Ho Lee
Background:There is little information on the optimal storage conditions for recovery of nontuberculous Mycobacterium spp. (NTM) from refrigerated sputum.Objectives:We investigated the storage dura...
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Effect of coronaviruses on blood vessel permeability: potential therapeutic targets Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-17 Nicolle R. Machado, Karina T. Dias, Bryan F.S. Cortes, Stephen F. Rodrigues
Coronavirus-induced diseases have afflicted humanity for several decades. This scenario was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in Wuhan, China, in December...
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Bronchoscopic interventions for bronchopleural fistulas Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-17 Lingli Jin, Yaqing Li
Bronchopleural fistula is a potentially fatal disease most often caused after pneumonectomy. Concomitant problems such as pulmonary infection and respiratory failure are typically the main contribu...
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Oxygen insufflation through the bronchoscope channel for sedation-induced hypoxia: safe and effective Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-17 Wissam Abouzgheib, Henry Miller, Thaddeus Bartter
Objectives:To evaluate both efficacy and safety parameters for insufflation through the bronchoscope as a method of recovery from sedation-induced hypoxia. To explore parameters applicable to use i...
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Characteristics of initiators of budesonide/glycopyrrolate/formoterol for treatment of chronic obstructive pulmonary disease (COPD) in the United States: the AURA study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-04 Edward C. Portillo, Michael Pollack, Inyoung Lee, Kainan Sun, Xiaohui Zhao, Lisa Kruse, Norbert Feigler, Sushma Patel, Aimee M. Near
Introduction:A twice-daily single inhaler triple therapy consisting of budesonide/glycopyrrolate/formoterol fumarate (BGF) was approved by the US Food and Drug Administration (FDA) in July 2020 as ...
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Similarities and differences between the cough suppression test and the cough challenge test Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-04 Kun Zhao, Xiao Bai, Siwan Wen, Shengyuan Wang, Xianghuai Xu, Li Yu
In recent years, a new test method namely the cough suppression test has been proposed to measure cough suppression in patients with chronic cough. The cough suppression test is a modified test bas...
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Treatment patterns in patients with stable COPD in China: analysis of a prospective, 52-week, nationwide, observational cohort study (REAL) Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-04-04 Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Yahong Chen, Wenhua Jian, Chen Wang
Background:Underdiagnosis and undertreatment pose major barriers to optimal management of chronic obstructive pulmonary disease (COPD) in China.Objective:The REAL trial was performed to generate re...
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Torsed extralobar pulmonary sequestration associated with congenital lobar emphysema: a rare entity Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-29 Yuhao Wu, Linyun Xi, Zhengxia Pan, Chun Wu, Hongbo Li
Pulmonary sequestration (PS) is a rare congenital malformation, which mainly contains two variants involving extralobar and intralobar sequestrations. Extralobar sequestrations (ELS) are isolated f...
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Effects of exercise-based pulmonary rehabilitation on severe/very severe COPD: a systematic review and meta-analysis Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-22 Wenqing He, Jiajia Wang, Zhenzhen Feng, Jiansheng Li, Yang Xie
Objective:Pulmonary rehabilitation (PR) has been considered to be an effective treatment method for various respiratory diseases. However, the effects of exercise-based PR on patients with severe/v...
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Trends of therapy in the treatment of asthma Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-21 Xiaodi Lv, Zhen Gao, Weifeng Tang, Jingjing Qin, Wenqian Wang, Jiaqi Liu, Mihui Li, Fangzhou Teng, La Yi, Jingcheng Dong, Ying Wei
Background:To better understand the development of therapy for asthma, grasp the core paradigm associated with the transformation of cognition of asthma treatment and asthma, explore potential and ...
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The efficacy of N-acetylcysteine in chronic obstructive pulmonary disease patients: a meta-analysis Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-17 Chienhsiu Huang, Sufang Kuo, Lichen Lin, Yalun Yang
Background:N-acetylcysteine (NAC) may reduce acute exacerbations of chronic obstructive pulmonary disease through an antioxidant effect. Due to the heterogeneity in studies, the currently available...
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Diagnostic accuracy of pleural fluid to serum carcinoembryonic antigen ratio and delta value for malignant pleural effusion: findings from two cohorts Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-17 Meng-Ping Jiang, Jian-Xun Wen, Ling Hai, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Ya-Fei Wang, Wen-Qi Zheng, Zhi-De Hu, Li Yan
Background:Pleural fluid (PF) carcinoembryonic antigen (CEA) is a widely used diagnostic marker for malignant pleural effusion (MPE). Recent studies revealed that PF to serum CEA was also a promisi...
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Pulmonary sarcoidosis complicated by rheumatoid arthritis in a patient presenting with progressive fibrosing interstitial lung disease and treated with nintedanib: a case report and literature review Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-03-06 Ayana Suzuki, Koichiro Kamio, Mitsuhiro Takeno, Yasuhiro Terasaki, Namiko Taniuchi, Junpei Sato, Nobuhiko Nishijima, Yoshinobu Saito, Masahiro Seike, Akihiko Gemma, Arata Azuma
Sarcoidosis is a multisystem disease with an unknown etiology and is characterized by the formation of noncaseating granulomas in the affected organs. We present the case of a 69-year-old male Japa...
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Academic performance in children with pectus excavatum: a real-world research with propensity score matching Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-27 Hongbo Li, Shulei Fan, Xiangpan Kong, Zhengxia Pan, Chun Wu, Yonggang Li, Gang Wang, Jiangtao Dai, Dawei He, Quan Wang
Background:The optimal timing of surgery for pectus excavatum (PE) is controversial. A large proportion of children will not undergo surgery before puberty. However, untimely surgery may lead to a ...
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Real-life therapeutic effects of beclomethasone dipropionate/formoterol fumarate/glycopyrronium combined triple therapy in patients with chronic obstructive pulmonary disease Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-27 Corrado Pelaia, Giada Procopio, Fioramante Lello Rotundo, Maria Rosaria Deodato, Anna Ferrante Bannera, Francesco Giuseppe Tropea, Anna Cancelliere, Alessandro Vatrella, Girolamo Pelaia
Background:The small airway disease has been recognized as a central feature of chronic obstructive pulmonary disease (COPD). Triple fixed combination beclomethasone dipropionate/formoterol fumarat...
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Venous thromboembolism in patients with idiopathic pulmonary fibrosis, based on nationwide claim data Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-27 Jang Ho Lee, Hoon Hee Lee, Hyung Jun Park, Seonok Kim, Ye-Jee Kim, Jae Seung Lee, Ho Cheol Kim
Background:Idiopathic pulmonary fibrosis (IPF) is a known risk factor for venous thromboembolism (VTE). However, it is currently unknown which factors are associated with an increase of VTE in pati...
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Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-27 Lijuan Gao, Wujun Wang, Ying Zhang, Xueru Hu, Jing An, Yang Li, Mei Chen, Yongchun Shen
Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed p...
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Ventilatory ratio and mechanical power in prolonged mechanically ventilated COVID-19 patients versus respiratory failures of other etiologies Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-27 Alessandro Ghiani, Konstantinos Tsitouras, Joanna Paderewska, Kathrin Kahnert, Swenja Walcher, Lukas Gernhold, Claus Neurohr, Nikolaus Kneidinger
Background:Evidence suggests differences in ventilation efficiency and respiratory mechanics between early COVID-19 pneumonia and classical acute respiratory distress syndrome (ARDS), as measured b...
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Healthcare use and medical cost before and after diagnosis of nontuberculous mycobacterial infection in Korea: the National Health Insurance Service-National Sample Cohort Study Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-02-17 Seung Won Lee, Shihwan Chang, Youngmok Park, Sol Kim, Hojoon Sohn, Young Ae Kang
Background and objective:The global prevalence and incidence of nontuberculous mycobacterial (NTM) infections are increasing; however, population-level data on healthcare use and medical costs for ...
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Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-31 Kathrin Kahnert, Rudolf A. Jörres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Jürgen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, Jürgen Biederer
Background:Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of sta...
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Comparison of clinical outcomes in critically ill COVID-19 patients on mechanical ventilation with nosocomial pneumonia between Alpha and Omicron variants. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Chuan-Yen Sun,Jhong-Ru Huang,Hsiao-Chin Shen,Ying-Ting Liao,Hung-Jui Ko,Chih-Jung Chang,Yuh-Min Chen,Jia-Yih Feng,Wei-Chih Chen,Kuang-Yao Yang
BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pandemic that has resulted in millions of deaths worldwide. Critically ill COVID-19 patients who require intubation and develop nosocomial pneumonia, commonly caused by gram-negative bacilli, have a higher mortality rate than those without nosocomial pneumonia. OBJECTIVES The aim of
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The future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease in various GOLD groups: a focus on the GOLD 2017 and GOLD 2023 reports. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Qing Song,Wei Cheng,Cong Liu,Xueshan Li,Ling Lin,Yating Peng,Yuqin Zeng,Rong Yi,Yi Liu,Xin Li,Yan Chen,Shan Cai,Ping Chen
BACKGROUND The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 report revised the combined assessment, merged the C and D groups into the E group, and revised the initial inhalation therapy recommendation. OBJECTIVES This study aimed to analyze the future exacerbation and mortality of different inhalation therapies among patients with chronic obstructive pulmonary disease (COPD)
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Hyperinflation and reduced diffusing capacity predict prognosis in SCLC: value of extended pre-therapeutic lung function testing. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Kathrin Kahnert,Lilli Maria Lempert,Jürgen Behr,Laura Elsner,Toki Bolt,Amanda Tufman,Diego Kauffmann-Guerrero
BACKGROUND Small cell lung cancer (SCLC) is characterized by aggressive growth and poor prognosis. Although SCLC affects nearly exclusively heavy smokers and leads to frequent respiratory symptoms, the impact of pre-therapeutic lung function testing in SCLC is sparely investigated until now. Therefore, we sought to examine whether we could find prognostic markers in pre-therapeutic lung function testing
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Ultrasonography - a novel auxiliary interpretive approach for tuberculin-purified pure protein derivative skin test: a comparative study. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Weijie Jiao,Yi Huang,Ying Lei,Jun Zhang,Ming Yu
BACKGROUND The tuberculin-purified protein derivative (PPD) test is commonly used as a screening tool for tuberculosis (TB). However, the traditional judgment standard of the PPD test is influenced by subjective factors, which can lead to less accurate and intuitive test results. OBJECTIVES To evaluate the accuracy of ultrasonography as a novel auxiliary judgment method for the tuberculin-PPD test
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Factors for progressive pulmonary fibrosis in connective tissue disease-related interstitial lung disease. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Kyuhwan Kim,Jongmin Lee,Yong Suk Jo
BACKGROUND Progressive fibrosis can occur in connective tissue disease (CTD)-related interstitial lung disease (ILD) and make the prognosis worse. OBJECTIVES This study aimed to investigate factors related to progressive pulmonary fibrosis (PPF) phenotype in CTD-ILDs. DESIGN Medical records of patients diagnosed as CTD and ILD at a single, tertiary hospital in South Korea were retrospectively reviewed
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Clinical characteristics and outcomes of hypersensitivity pneumonitis in South Korea. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Sungmin Zo,Man Pyo Chung,Hak Young Yoo,Kyung Soo Lee,Joungho Han,Myung Jin Chung,Hongseok Yoo
BACKGROUND Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from an immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP in South Korea are not well understood. OBJECTIVES This study was conducted to identify the clinical characteristics and outcomes of HP in South Korea. DESIGN This
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Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Laurent Guilleminault,Claire Camus,Chantal Raherison-Semjen,Audrey Capdepon,Arnaud Bourdin,Philippe Bonniaud,Stéphanie Fry,Gilles Devouassoux,François-Xavier Blanc,Christophe Pison,Clairelyne Dupin,Naji Khayath,Joelle Courdeau,Judith Valcke-Brossollet,Cécilia Nocent-Ejnaini,Fabien Rolland,Carmen Lamandi,Alain Proust,Anaig Ozier,Laurent Portel,Wanda Gaspard,Pauline Roux-Claude,Antoine Beurnier,Stéphanie
BACKGROUND Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics. PURPOSE We aim to describe asthma control and healthcare consumption of severe asthma patients
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Role of Nrf2 and exercise in alleviating COPD-induced skeletal muscle dysfunction. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Meiling Jiang,Peijun Li,Yingqi Wang,Yuanyuan Cao,Xiaoyu Han,Linhong Jiang,Xiaodan Liu,Weibing Wu
Chronic obstructive pulmonary disease (COPD) is a complex chronic respiratory disease with cumulative impacts on multiple systems, exhibiting significant extrapulmonary impacts, and posing a serious public health problem. Skeletal muscle dysfunction is one of the most pronounced extrapulmonary effects in patients with COPD, which severely affects patient prognosis and mortality primarily through reduced
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Analysis of the effect of cytomegalovirus infection in clinical outcomes and prolonged duration of SARS-CoV-2 shedding in intensive care unit patients with COVID-19 pneumonia. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Hsiao-Chin Shen,Jia-Yih Feng,Chuan-Yen Sun,Jhong-Ru Huang,Yuh-Min Chen,Wei-Chih Chen,Kuang-Yao Yang
BACKGROUND Coronavirus disease 2019 (COVID-19) is a global outbreak disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cytomegalovirus (CMV) infection can occur in critical COVID-19 patients and is associated with adverse clinical outcomes. OBJECTIVE The aim of this study was to explore the clinical characteristics and outcome of CMV infection in critical
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Ferroptosis triggers airway inflammation in asthma. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Minming Li,Min Li,Yunjiao Hou,Huilin He,Ruonan Jiang,Chu Wang,Shibo Sun
Ferroptosis is a regulatory cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress. Many signaling pathways such as iron metabolism, lipid metabolism, and amino acid metabolism precisely regulate the process of ferroptosis. Ferroptosis is involved in a variety of lung diseases, such as acute lung injury, chronic obstructive pulmonary disease
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Development and validation of a machine learning model for differential diagnosis of malignant pleural effusion using routine laboratory data. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Ting-Ting Wei,Jia-Feng Zhang,Zhuo Cheng,Lei Jiang,Jiang-Yan Li,Lin Zhou
BACKGROUND The differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE) presents a clinical challenge. In recent years, the use of artificial intelligence (AI) machine learning models for disease diagnosis has increased. OBJECTIVE This study aimed to develop and validate a diagnostic model for early differentiation between MPE and BPE based on routine laboratory
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Clinical factors linked to the type of respiratory medication in COPD: results from the COSYCONET cohort. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Peter Alter,Kathrin Kahnert,Franziska C Trudzinski,Robert Bals,Henrik Watz,Tim Speicher,Sandra Söhler,Tobias Welte,Klaus F Rabe,Emiel F M Wouters,Claus F Vogelmeier,Rudolf A Jörres
BACKGROUND The use of maintenance medication in patients with chronic obstructive pulmonary disease (COPD) in real life is known to deviate from recommendations in guidelines, which are largely based on randomized controlled trials and selected populations. OBJECTIVES We used the COSYCONET (COPD and Systemic Consequences - Comorbidities Network) cohort to analyze factors linked to the use of COPD drugs
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Stepwise management of COPD: What is next after bronchodilation? Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Marc Miravitlles,Kazuto Matsunaga,Michael Dreher
Inhaled bronchodilator therapy with long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) in combination is currently the mainstay of treatment for chronic obstructive pulmonary disease (COPD). Treatment guidelines recommend the addition of inhaled corticosteroids (ICS) to LABA/LAMA only in patients with a history of frequent/severe exacerbations and high blood eosinophil counts
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An unexpected encounter and outcome between endobronchial lipoma and carcinoma: a case report and literature review. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Yang Yang,Jun Liu,Songkuan Chen,Guangzhao Yang,Guoqun Mao,Xiaoyu Han,Jian Wang
Bronchial lipoma is a rare benign tumor of the lung, which is often misdiagnosed due to concomitant pulmonary diseases. In addition, the coexistence of endobronchial lipoma and lung cancer is extremely unusual. To date, no related computed tomography (CT) images have been reported. The patient was a 53-year-old man, who was admitted to our hospital with cough, yellow phlegm, and fever for 1 week. The
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Associations of medication regimen complexity with medication adherence and clinical outcomes in patients with chronic obstructive pulmonary disease: a prospective study. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Ruoxi He,Ye Wang,Xiaoxia Ren,Ke Huang,Jieping Lei,Hongtao Niu,Wei Li,Fen Dong,Baicun Li,Ting Yang,Chen Wang
BACKGROUND High medication burdens are common in patients with chronic obstructive pulmonary disease (COPD). This study aimed to explore the associations of medication regimen complexity index (MRCI) with medication adherence and clinical outcomes among patients with acute exacerbations of COPD (AECOPD) after hospital discharge. METHODS Data were obtained from a nationwide cohort study of inpatients
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All-cause readmission rate and risk factors of 30- and 90-day after discharge in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Huanrong Ruan,Hulei Zhao,Jiajia Wang,Hailong Zhang,Jiansheng Li
BACKGROUND The readmission rate following hospitalization for chronic obstructive pulmonary disease (COPD) is surprisingly high, and frequent readmissions represent a higher risk of mortality and a heavy economic burden. However, information on all-cause readmissions in patients with COPD is limited. OBJECTIVE This study aimed to systematically summarize all-cause COPD readmission rates within 30 and
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Long-term impact of add-on sequential triple combination therapy in pulmonary arterial hypertension: real world experience. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Himanshu Deshwal,Tatiana Weinstein,Rachel Salyer,Jesse Thompson,Frank Cefali,Rebecca Fenton,Eric Bondarsky,Roxana Sulica
BACKGROUND Sequential triple combination therapy is recommended for pulmonary arterial hypertension (PAH) patients who are not at therapeutic goal on dual therapy, but long-term data on efficacy and safety is scarce. OBJECTIVE To assess the long-term impact of sequential triple combination therapy in patients with PAH who are not at goal on dual combination therapy. STUDY DESIGN AND METHODS We performed
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Novel inflammatory biomarkers in the prognosis of COVID-19. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Kegang Zhan,Luhan Wang,Hao Lin,Xiaoyu Fang,Hong Jia,Xiangyu Ma
BACKGROUND The central role of inflammatory progression in the development of Coronavirus disease 2019 (COVID-19), especially in severe cases, is indisputable. However, the role of some novel inflammatory biomarkers in the prognosis of COVID-19 remains controversial. OBJECTIVE To assess the effect of some novel inflammatory biomarkers in the occurrence and prognosis of COVID-19. METHODS We systematically
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The perfect storm: temporal analysis of air during the world's most deadly epidemic thunderstorm asthma (ETSA) event in Melbourne. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Dwan Price,Kira M Hughes,Dulashi Withanage Dona,Philip E Taylor,David A V Morton,Svetlana Stevanovic,Francis Thien,Jason Choi,Paul Torre,Cenk Suphioglu
BACKGROUND There have been 26 epidemic thunderstorm asthma (ETSA) events worldwide, with Melbourne at the epicentre of ETSA with 7 recorded events, and in 2016 experienced the deadliest ETSA event ever recorded. Health services and emergency departments were overwhelmed with thousands requiring medical care for acute asthma and 10 people died. OBJECTIVES This multidisciplinary study was conducted across
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Arterial lactate as a risk factor for death in respiratory failure related to coronavirus disease 2019: an observational study. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Giorgio Maraziti,Laura Marchini,Greta Barbieri,Marco Falcone,Francesco Corradi,Mara Graziani,Lorenzo Ghiadoni,Cecilia Becattini
BACKGROUND Arterial lactate is a recognized biomarker associated with death in critically ill patients. The prognostic role of arterial lactate in acute respiratory failure due to the novel coronavirus disease 2019 (COVID-19) is unclear. OBJECTIVES We aimed to investigate the prognostic role of arterial lactate levels at admission in patients with COVID-19-related acute respiratory failure. DESIGN
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Symptom versus exacerbation control: an evolution in GINA guidelines? Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Manuela Latorre,Riccardo Pistelli,Giovanna Elisiana Carpagnano,Alessandro Celi,Ilaria Puxeddu,Nicola Scichilone,Antonio Spanevello,Giorgio Walter Canonica,Pierluigi Paggiaro
The article traces the concept of asthma control within GINA guidelines over the past 25 years. In the first 15 years after 1995, the main objective of asthma management was to obtain the control of all clinical and functional characteristics of asthma. A landmark study (GOAL) showed for the first time that a good control of asthma is a reasonable outcome that can be achieved in a large proportion
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Management and outcome of obstructive airway complications after lung transplantation - a 12-year retrospective cohort study. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Jens Gottlieb,Thomas Fuehner,Patrick Zardo
BACKGROUND Obstructive airway complications (OACs) represent a significant problem after lung transplantation (LTx). Bilateral OACs after double lung transplantation are infrequently reported. OBJECTIVES The aim of this study was to investigate management and outcome of OAC. DESIGN Retrospective single-center cohort study. METHODS Adult patients with bilateral LTx performed between 2010 and 2021 were
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Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Heather Lynn,Xiaoguang Sun,Nancy G Casanova,Christian Bime,Vivian Reyes Hernon,Clayton Lanham,Radu C Oita,Nikolas Ramos,Belinda Sun,Dawn K Coletta,Sara M Camp,Jason H Karnes,Nathan A Ellis,Joe G N Garcia
BACKGROUND AND OBJECTIVES eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity. This study assesses the previously unknown influence of NAMPT promoter SNPs on NAMPT transcription, eNAMPT secretion, and ARDS severity. METHODS AND DESIGN Human lung endothelial cells (ECs)
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Effects of walking with a portable oxygen concentrator on muscle oxygenation while performing normal or pursed-lip breathing in patients with interstitial lung disease: a randomized crossover trial. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Sang Hun Kim,Yong Beom Shin,Myung-Jun Shin,Cho Hui Hong,Sungchul Huh,Wanho Yoo,Kwangha Lee
BACKGROUND In patients with interstitial lung disease (ILD), decreased oxygen saturation (SpO2) reduces physical performance and causes exertional dyspnea. Portable oxygen concentrator (POC) and pursed-lip breathing (PLB) have the potential to improve these parameters in ILD patients. OBJECTIVE To evaluate the effects of PLB while using a POC during walking in ILD patients. DESIGN Prospective, randomized
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Long-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis. Ther. Adv. Respir. Dis. (IF 4.3) Pub Date : 2023-01-01 Li-Qin Lin,Di-Fei Chen,Hong-Kai Wu,Yu Chen,Chang-Hao Zhong,Xiao-Bo Chen,Chun-Li Tang,Zi-Qing Zhou,Shi-Yue Li
BACKGROUND The long-term efficacy of the Dumon stent in the treatment of benign airway stenosis is unclear. OBJECTIVE The objective of this study was to evaluate the long-term efficacy and safety of the Dumon stent in patients with benign airway stenosis. METHODS We retrospectively reviewed patients with benign airway stenosis who were treated with a Dumon stent at the First Affiliated Hospital of