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Novel therapies for eosinophilic pediatric plastic bronchitis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-16 Katherine Briski, Bahaaeldin Labib, Sabiha Hussain, Maya Ramagopal, Lakshmi Uppaluri
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Misconceptions on behavioral cough suppression therapy for pediatric nonspecific cough: A response to Weinberger and Buettner's commentary on Fujiki et al. Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-14 Laurie Slovarp, Marie Jette, Jane Reynolds, Amanda I Gillespie, Julie Barkmeier‐Kraemer, Mary Sandage, Jaclyn Smith, Jemma Haines, Anne Vertigan, Stuart Mazzone
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Inspired oxygen fraction thresholds to accurately predict surfactant administration in neonatal RDS is gestational age strata: A pragmatic, multi-center study Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Francesco Raimondi, Pasquale Dolce, Claudio Veropalumbo, Enrico Sierchio, Iuri Corsini, Fabio Meneghin, Silvia Lama, Roberto Raschetti, Silvia Varano, Alessandro Perri, Luca Bonadies, Almudena Alonso Ojembarrena, Javier Rodriguez Fanjul, Rebeca Gregorio Hernandez, Lorena Rodeño Fernandez, Peter G. Davis, Letizia Capasso
Current international guidelines on neonatal respiratory distress syndrome (RDS) recommend continuous positive airway pressure (CPAP) stabilization as primary treatment. Some guidelines recommend surfactant replacement for babies requiring FiO2 > 0.3 regardless of gestational age (GA). We explore the accuracy of alternative inspired oxygen fraction (FiO2) thresholds as early predictors of surfactant
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Respiratory morbidity among offspring misclassified as growth restricted Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Omri Zamstein, Tamar Wainstock, Eyal Sheiner
ObjectiveAn ultrasound‐based diagnosis implies that some fetuses suspected to be growth‐restricted (FGR) are discovered at birth to be appropriately grown (appropriate for gestational age [AGA] birth weight, between the 10th and 90th percentile). These fetuses may thus be exposed to unnecessary medical interventions, including early labor induction. In this study, we have evaluated the long‐term respiratory
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Clinical outcomes at 9–10 years of age in children born with cystic fibrosis transmembrane conductance regulator related metabolic syndrome Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Brian J. Carroll, Joshua S. Ostrenga, Aliza K. Fink, Nicholas J. Antos, Elizabeth A. Cromwell, Clement L. Ren
Background and ObjectivesThere are limited data on cystic fibrosis (CF) transmembrane conductance regulator‐related metabolic syndrome (CRMS) outcomes beyond infancy. The goal of this study was to analyze outcomes of infants with CRMS up to the age of 9–10 years using the CF Foundation Patient Registry (CFFPR).MethodsWe analyzed data from the CFFPR for individuals with CF and CRMS born between 2010
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Outdoor air pollution and near‐fatal/fatal asthma attacks in children: A systematic review Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Deepa Varghese, Kathryn Ferris, Bohee Lee, Jonathan Grigg, Hilary Pinnock, Steve Cunningham
BackgroundGlobally, observational studies have demonstrated an association between high levels of air pollution and asthma attacks in children. It remains unclear whether and to what extent exposure may be associated with increased near‐fatal/fatal attacks.ObjectiveTo systematically review the evidence for an association between ambient outdoor air pollution and fatal and/or near‐fatal asthma (NFA)
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Assessment of nocturnal alveolar hypoventilation and obstructive sleep apnea in otherwise healthy children Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Julie Cassibba, Jessica Taytard, Jade Merrer, Marie‐Claude La Rocca, Houda Saleh‐Guillo, Nicole Beydon
Obstructive sleep apnea (OSA) is a common disorder in children without co-morbidities (otherwise healthy children), with an estimated prevalence of 1%–4%.1 Polysomnography (PSG) in a sleep laboratory is the gold standard to confirm the diagnosis of OSA and assess its severity.1 However, PSG is cumbersome and costly, and requires special technical skills, which makes its use difficult to generalize
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Early‐life respiratory infection: How do we react to this red flag? Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-13 Andrew Bush, Danilo Buonsenso, Diego Peroni, Michele Piazza, Giorgio Piacentini, Attilio L. Boner
A recent manuscript highlighted that early childhood lower respiratory tract infection (LRTI) is associated with a nearly twofold increased risk of premature adult death.1 Whether infection is causal of later mortality, or a marker of high risk is unclear. Nonetheless, very early LRTI is a clear indication of future risk. However, this is not recognized in guidelines on the management of community-acquired
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Exploring perceptions of and decision‐making about CFTR modulators Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-08 Lee Landess, Mary G. Prieur, Ashley R. Brown, Elisabeth P. Dellon
IntroductionCystic fibrosis (CF) treatment has increasingly focused on highly effective modulators. Despite measurable benefits of modulators, there is little guidance for CF care team members on providing education and support to patients regarding initiation of these therapies. We aimed to explore patient, caregiver, and clinician perceptions of modulators and influences on decisions about starting
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Real‐time ultrasound‐guided segmental bronchoscopic insufflation in a Tay‐Sachs patient with atelectasis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-07 Matej Šapina, Bojana Olujic, Tihana Nađ, Hrvoje Vinkovic, Zdravka Krivdić Dupan, Nikolina Hamidović, Mia Damašek, Krešimir Milas, Željko Zubčić, Ivan Erić
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Time‐domain near‐infrared spectroscopy to assess pulmonary circulation in single‐ventricle physiology Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Tomohiko Suemori, Takashi Yamada, Naoyuki Taga, Masaaki Satoh, Mamoru Takeuchi
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Transitioning children using home invasive mechanical ventilation from hospital to home: Discharge criteria, disparities, and ethical considerations Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Jennifer Henningfeld, Annie B. Friedrich, Grace Flanagan, Cynthia Griffith, Anna Hughes, Lisa Molkentine, Rebecca Steuart, Stuart Wilkinson, Christopher D. Baker
Children using home invasive mechanical ventilation (HIMV), a valuable therapeutic option for chronic respiratory failure, constitute a growing population. Transitioning children using HIMV from hospital to home care is a complex process that requires a multidisciplinary approach involving healthcare professionals, caregivers, and community resources. Medical stability, caregiver competence, and home
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Causes and management of urinary system problems in children on long‐term home invasive mechanical ventilation Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Alper Soylu, Salih Kavukcu
Many ventilator‐dependent children have comorbid conditions including urinary tract disorders. We aimed to present a focused review of the literature describing the causes and management of urinary system problems in children with long‐term home mechanical ventilation. We performed a literature search in PubMed/MEDLINE, Scopus, and Web of Science with keywords “children,” “home mechanical ventilation
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A left‐sided destroyed lung in a 11‐year‐old girl: A rare sequela after Mycoplasma pneumoniae infection Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Maoyi Zuo, Hao Wang, Huaping Zhu
Mycoplasma pneumoniae infection is one of the most common causes of community‐acquired pneumonia in children, usually experiencing a favorable prognosis.Cases of M. pneumoniae infection resulting in respiratory failure, severe pulmonary or extrapulmonary sequelae, and death are relatively rare.Currently, no cases related to a destroyed lung with Mycoplasma‐associated infection have been reported.Therefore
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Tracheal bronchus related symptoms in a premature neonate: The role of lung ultrasound in the management of this condition Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Alessandro Perri, Giorgia Prontera, Simona Fattore, Annamaria Sbordone, Maria Letizia Patti, Vito D'andrea, Stefano Nobile, Giovanni Vento
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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The case of the disappearing foreign body Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Veena Raghunathan, Maninder Dhaliwal, Deepak Pahwa, Nitin Jain, Ashok Rijhwani
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Measurement of lung oxygenation by near‐infrared spectroscopy in preterm infants with bronchopulmonary dysplasia Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-05 Carlo Dani, Francesca Miselli, Tommaso Zini, Davide Scarponi, Michele Luzzati, Davide Sarcina, Monica Fusco, Francesco Dianori, Alberto Berardi
IntroductionIt has recently been reported that it is possible to monitor lung oxygenation (rSO2L) by near‐infrared spectroscopy (NIRS) in preterm infants with respiratory distress syndrome (RDS). Thus, our aim was to assess the possibility of monitoring rSO2L in infants with evolving and established bronchopulmonary dysplasia (BPD) and to evaluate if rSO2L correlates with BPD severity and other oxygenation
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Variability in evaluation and follow-up of newborns with CRMS/CFSPID in New York State Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-01 Catherine Kier, Denise M. Kay, Elinor Langfelder-Schwind, Danielle M. Goetz, Maria Berdella, Joan K. DeCelie-Germana, Zafer N. Soultan, Michele Caggana, Christopher N. Fortner, Robert Giusti, Robert Kaslovsky, Karen Voter, John J. Welter, , Hossein Sadeghi
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Relationship between FEV1/FVC and age in children with asthma Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-01 Amal Ahmed, Amy Brown, Yehudit Pollack, Joshua Vazhappilly, Carrighan Perry, Erica R. Thomas, Sankaran Krishnan, Allen J. Dozor
IntroductionForced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) normally decreases through childhood, increases briefly during early adolescence, and then declines throughout life. The physiology behind this temporary increase during early adolescence is not well understood. The objective of this study was to determine if this pattern occurs in children with asthma.DesignSingle‐center
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Autism and neurodevelopmental disability risks in children with tracheostomies and ventilators Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-01 Sarah A. Sobotka, Emma Lynch, Chuanhong Liao, Robert J. Graham, Michael E. Msall
Background/ObjectiveInfants who survive prematurity and other critical illnesses and require continued invasive mechanical ventilation (IMV) postdischarge (at home) are at high risk of developmental delays and disabilities. Studies of extremely preterm cohorts (<28‐week gestation) demonstrate rates of 25% for intellectual disability (ID) and 7% for autism spectrum disorder (ASD). Rates of ASD and ID
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Continuous positive airway pressure in children under 6 years with severe acute lower respiratory infections: Systematic review and metanalysis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-03-01 Jefferson A. Buendía, Diana Guerrero Patiño, Andrés Felipe Zuluaga Salazar
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Radiographic uncertainty and outcomes of children with lower respiratory tract infections Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-28 Sriram Ramgopal, Jillian M. Cotter, Nidhya Navanandan, Lilliam Ambroggio, Kenneth A. Michelson, Todd A. Florin
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Lung clearance index (LCI2.5) changes after initiation of Elexacaftor/Tezacaftor/Ivacaftor in children with cystic fibrosis aged between 6 and 11 years: The “real‐world” differs from trial data Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-28 Don S. Urquhart, Heather Dowle, Kellie Moffat, Jody Forster, Steve Cunningham, Kenneth A. Macleod
BackgroundElexacaftor in combination with Tezacaftor and Ivacaftor (ETI) became licensed in the United Kingdom in early 2022 for children aged 6–11 years with cystic fibrosis (CF) and an eligible mutation. Many in this age group have excellent prior lung health making quantitative measurement of benefit challenging. Clinical trials purport that lung clearance index (LCI2.5) measurement is most suitable
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The utility of elective flexible bronchoscopy to improve quality of life and clinical outcomes for children: A systematic review Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-27 Rahul J. Thomas, Stephanie T. Yerkovich, Vikas Goyal, Anne B. Chang, Cameron Rutter, Ian Brent Masters, Julie M. Marchant
IntroductionElective flexible bronchoscopy (FB) is now widely available and standard practice for a variety of indications in children with respiratory conditions. However, there is limited evidence regarding the utility of elective FB in children. This systematic review (SRs) aimed to determine the utility of FB on its impact in clinical decision making and quality of life (QoL).MethodsWe searched
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Pediatric Asthma Therapy Assessment Questionnaire for the Brazilian population: Cross‐cultural adaptation and measurement properties Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-27 Thayla Amorim Santino, Hesli de Sousa Holanda, Juliana Cirilo Soares de Souza, Maria Clara Almeida Jácome, Fernanda Elizabeth Pereira da Silva Menescal, Joubert Vitor de Souto Barbosa, Ada Cristina Jácome, Cleia Teixeira do Amaral, João Carlos Alchieri, Karla Morganna Pereira Pinto de Mendonça
ObjectiveTo cross‐culturally adapt the Pediatric Asthma Therapy Assessment Questionnaire (ATAQ) into Brazilian Portuguese and analyze its measurement properties.MethodsThis exploratory methodological study included eight experts and 30 caregivers in the translation and cross‐cultural adaptation steps. Thereafter, 118 caregivers of pediatric patients with asthma aged between 5 and 17 years were involved
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Initial characteristics of cystic fibrosis in Algeria: Description of 34 pediatric cases Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-27 Imene Bendoukha, Zahia Boucherit‐Otmani, Zahira Zakia Baba Ahmed‐Kazi Tani, Abdelfettah Seghir, Mourad Madouni, Abdel Karim Radoui, Kebir Boucherit
BackgroundCystic fibrosis (CF) is a rare disease in Algeria, and its prognosis is poor in developing countries. The clinical and demographic knowledge of Algerian pediatric patients diagnosed with CF is incomplete due to the nonexistence of a national medical registry. Hence, the present study is the first Algerian multicentre study on CF.MethodsThis retrospective study was conducted in western Algeria
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Successful atorvastatin treatment of pulmonary alveolar proteinosis in a child with GM‐CSF receptor deficiency Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-27 Halime Nayır Büyükşahin, Ebru Yalçın, Ali Özdemir, Mithat Haliloglu, Diclehan Orhan, Matthias Griese, Florian Gothe, Christina Rapp, Sandra Gräfin v. Hardenberg, Sehend Debbağ, İsmail Güzelkaş, Nagehan Emiralioğlu, Deniz Doğru, Uğur Özçelik, Nural Kiper
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Retrospective study of serial polysomnograms of bronchopulmonary dysplasia patients with oxygen dependence Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-27 Deena Yousif, Chiara Cerini, Sally Ward, Narayan Iyer, Roberta Kato, Ramon Durazo‐Arvizu, Manvi Bansal
IntroductionThis retrospective study describes characteristics of serial polysomnograms (PSGs) of BPD patients on home oxygen therapy and describes PSG parameters associated with discontinuation of supplemental oxygen.MethodsA single‐center study was performed at Children's Hospital Los Angeles, where serial PSGs for 44 patients with BPD infants discharged on home oxygen therapy were extracted for
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An unusual case of metastatic trophoblastic neoplasm presenting with diffuse cystic lung disease and pulmonary artery pseudoaneurysms in a teenager Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-23 Sevim Guler, Nathan C. Hull, Manuel Arteta, Wendy Allen‐Rhoades, Maryam Shahi, Michael B. Ishitani, Nadir Demirel
Diffuse cystic lung diseases (DCLDs) are a diverse group of lung disorders characterized by the presence of multiple air filled cysts within the lung tissue. These cysts are thin walled and surrounded by normal lung tissue. In adults, DCLD can be associated with various conditions such as lymphangioleiomyomatosis (LAM), Langerhans cell histiocytosis, cancers, and more. In children, DCLD is often linked
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Impulse oscillometry assessment of respiratory function in pediatric patients with a history of COVID‐19 Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-23 Adnan Mercan, Simge Atar Beşe, Zeynep Güleç Köksal, Soner Sertan Kara, Pınar Uysal, Duygu Erge
ObjectiveWhile coronavirus disease 2019 (COVID‐19) is generally considered to exhibit a less severe clinical course in children than in adults, studies have demonstrated that respiratory symptoms can endure for more than 3 months following infection in at least one‐third of pediatric cases. The present study evaluates the respiratory functions of children aged 3–15 years within 3–6 months of their
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Spontaneous pneumomediastinum: A complication of SARS‐CoV‐2 variant delta infection in children Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-23 Blandine Prevost, Pierre‐Louis Leger, Chiara Sileo, Fany Corvol, Thibault Lecarpentier, Nadia Nathan, Harriet Corvol
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Epidemiology of complications among hospitalized children with hereditary hemorrhagic telangiectasia: A kids' inpatient database study Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-21 Po‐Yang Tsou, Melisa Ruiz‐Gutierrez, Ahmad Alomari, Pei‐Lun Kuo, Timothy Klouda
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The utility of nasal nitric oxide in the diagnostic evaluation of primary ciliary dyskinesia Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-21 Katherine A. Carr, Paul E. Moore, Michael G. O'Connor
BackgroundThere is no gold‐standard test for primary ciliary dyskinesia (PCD), rather American Thoracic Society guidelines recommend starting with nasal nitric oxide (nNO) in children ≥5 years old and confirming the diagnosis with genetic testing or ciliary biopsy with transmission electron microscopy (TEM). These guidelines have not been studied in a clinical setting. We present a case series describing
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Time‐dependent gene–environment interactions are essential drivers of asthma initiation and persistence Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-21 Grigorios Chatziparasidis, Maria R. Chatziparasidi, Ahmad Kantar, Andrew Bush
Asthma is a clinical syndrome caused by heterogeneous underlying mechanisms with some of them having a strong genetic component. It is known that up to 82% of atopic asthma has a genetic background with the rest being influenced by environmental factors that cause epigenetic modification(s) of gene expression. The interaction between the gene(s) and the environment has long been regarded as the most
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Short-term effects of positive expiratory pressure mask on ventilation inhomogeneity in children with cystic fibrosis: A randomized, sham-controlled crossover study Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-16 Simone Gambazza, Alessandra Mariani, Riccardo Guarise, Beatrice Ferrari, Federica Carta, Anna Brivio, Sofia Bizzarri, Chiara Castellani, Carla Colombo, Dario Laquintana
Can physiotherapy with a positive expiratory pressure (PEP) mask improve peripheral ventilation inhomogeneity, a typical feature of children with cystic fibrosis (cwCF)? To answer this question, we used the nitrogen multiple-breath washout (N2MBW) test to measure diffusion-convection-dependent inhomogeneity arising within the intracinar compartment (Sacin*VT).
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Association between individual sensor behavior of an electronic nose and airways inflammation in children with asthma: a pilot study at alpine altitude climate Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-20 Giuliana Ferrante, Anna Luisa Cogo, Marco Sandri, Michele Piazza, Silvia Costella, Massimiliano Appodia, Raffaele Aralla, Laura Tenero, Marco Zaffanello, Giorgio Piacentini
BackgroundMarkers of airway inflammation can be helpful in the management of childhood asthma. Residential activities, such as intensive asthma camps at alpine altitude climate (AAC), can help reduce bronchial inflammation in patients who fail to achieve optimal control of the disease. Analysis of volatile organic compounds (VOCs) can be obtained using electronic devices such as e‐Noses. We aimed to
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Tracheobronchial abnormalities on computed tomography angiography in children with congenital heart disease Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-20 Harsimran Bhatia, Anmol Bhatia, Joseph L. Mathew, Akshay K. Saxena, Praveen Kumar, Karthi Nallasamy, Ting Tao, Kushaljit S. Sodhi
ObjectivesTo evaluate the assortment of tracheobronchial abnormalities on computed tomography angiography (CTA) in children with congenital heart disease (CHD).MethodsIn this study approved by the Institute ethics committee, CTA studies of 182 children (age range: 2 days–8 years) with CHD, performed from July 2021 to March 2023 were analyzed. Two pediatric radiologists independently assessed the tracheobronchial
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Me, myself, and I: A systematic review of cystic fibrosis and self‐concept Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-20 Maggie Harrigan, Melanie Jessup, Kellie Bennett, Siobhain Mulrennan
Given extensive pertinent disease factors and evolving medical treatments, this systematic review explores qualitative and quantitative cystic fibrosis (CF) research surrounding self‐concept, an overarching perception of self. Research methodologies, self‐concept dimensions, prominent self‐concept findings and clinical recommendations are identified. Preferred Reporting Items for Systematic Review
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Improved tracheostomy‐dependent patient outcomes after implementation of the Pediatric Resident Education in Pulmonary (PREP) Boot Camp Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-19 Erin K. Khan, Tai M. Lockspeiser, Maxene Meier, Deborah R. Liptzin, Christopher D. Baker
IntroductionChildren with tracheostomies are high risk for morbidity and mortality. Pediatric resident physicians are not routinely taught skills to care for this vulnerable patient population. Few reports link educational interventions to improved patient outcomes. This study evaluates the impact of an intensive educational training program on pediatric residents' observed skills and tracheostomy‐dependent
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Incidence, prevalence, and pattern of medical service utilization of children's rare lung diseases in South Korea Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-19 Hwan Soo Kim, Jiin Choi, Eun Lee, Ji Soo Park, Sungsu Jung, Jisun Yoon, Kyeong Hun Lee, Kyunghoon Kim, Hyeon‐Jong Yang, Dong In Suh
IntroductionChildren's rare lung diseases are a heterogeneous group of rare lung diseases with significant morbidity and mortality. There is very limited information on the incidence and prevalence of children's rare lung diseases in Asia. We investigated the nationwide incidence, prevalence, and pattern of medical service utilization of children's rare lung diseases in Korea.MethodsWe studied patients
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Major aortopulmonary collateral artery aneurysms—A rare cause of airway narrowing Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-19 Pavithra Subramanian, Shouvik Paul, Arun Sharma, Manphool Singhal
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Allergen immunotherapy in patients with severe asthma: A need for prospective trials Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-15 Margaret P. Huntwork, John C. Carlson
Allergen immunotherapy (AIT) alters the immune response to environmental allergens directly through mast cell desensitization, and indirectly through the induction of immunologic tolerance. First described in 1911,1 it has been extensively studied for its cost effectiveness, safety, and tolerability.2, 3 While on monthly immunotherapy injections, patients have significant reductions in asthma symptoms
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Longitudinal changes of swallowing safety and efficiency in infants with spinal muscular atrophy who received disease modifying therapies Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-15 Carmen Leon-Astudillo, Olivia Brooks, Stephanie M. Salabarria, Mackenzi Coker, Manuela Corti, Jenna Lammers, Emily K. Plowman, Barry J. Byrne, Barbara K. Smith
Dysphagia is a common feature of the natural history of patients with spinal muscular atrophy (SMA). Literature regarding swallowing safety and efficiency is scarce in patients with SMA, particularly in the era of newborn screening programs and disease-modifying therapies.
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Bicarotid trunk coexisting with anomalous right vertebral and aberrant right subclavian artery Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-15 Harsimran Bhatia, Chandra Shekhar Singh Aswal, Arun Sharma, Manphool Singhal
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Exploratory analysis of the economically justifiable price of nirsevimab for healthy late-preterm and term infants in Colombia Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-15 Jefferson Antonio Buendía, Ranniery Acuña-Cordero, Carlos E. Rodriguez-Martinez
Respiratory syncytial virus infection is the leading cause of lower respiratory infection globally. Recently, nirsevimab has been approved to prevent respiratory syncytial virus (RSV) infection. This study explores the economically justifiable price of nirsevimab for preventing RSV infection in Colombia's children under 1 year of age.
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Work of breathing: A tool for the respiratory management of severe bronchopulmonary dysplasia Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Benjamin Dudoignon, Sonia Khirani, Meryl Vedrenne-Cloquet, Alessandro Amaddeo, Plamen Bokov, Sylvain Renolleau, Brigitte Fauroux
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Fibrotic lung diseases in children Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Birce Sunman, Nural Kiper
In children, pulmonary fibrosis (PF) is an extremely unusual entity that can be observed in some types of interstitial lung disease (ILD). Defining whether ILD is accompanied by PF is important for targeted therapy. Algorithm for the diagnosis of PF in children is not clearly established. Besides, the clinical, radiological, and histological definitions commonly used to diagnose particularly the cases
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Impact of initial high flow nasal cannula flow rates on clinical outcomes in children with bronchiolitis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Nirupama Kannikeswaran, Robert R. Ehrman, Priya Spencer, Chaya Pitman-Hunt, Jacqueline Leja, Karima Lelak, Rajan Arora, Amy Delaroche
Our aim was to evaluate the impact of the initial high flow nasal cannula (HFNC) flow rate on clinical outcomes in children with bronchiolitis.
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Monitoring of physiologic features and treatment aspects of children on home invasive mechanical ventilation Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Jasneek Chawla, Hui-leng Tan
Pediatric home invasive mechanical ventilation patients are a small but resource-intensive cohort, requiring close monitoring and multidisciplinary care. Patients are often dependent on their ventilator for life support, with any significant complications such as equipment failure, tracheostomy blockage, or accidental decannulation becoming potentially life-threatening if not identified quickly. This
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Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Samar E. Atteih, Catherine R. Armbruster, Yasmin Hilliam, Glenn J. Rapsinski, Junu Koirala Bhusal, Leah L. Krainz, Jordan R. Gaston, Matthew DuPont, Anna C. Zemke, John F. Alcorn, John A. Moore, Vaughn S. Cooper, Stella E. Lee, Erick Forno, Jennifer M. Bomberger
While the widespread initiation of elexacaftor/tezacaftor/ivacaftor (ETI) has led to dramatic clinical improvements among persons with cystic fibrosis (pwCF), little is known about how ETI affects the respiratory mucosal inflammatory and physiochemical environment, or how these changes relate to lung function.
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Flow-resistive loading and diaphragmatic muscle function in term and preterm infants Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Theodore Dassios, Aggeliki Vervenioti, Asimina Tsintoni, Sotirios Fouzas, Ageliki A. Karatza, Gabriel Dimitriou
We aimed to assess diaphragmatic function in term and preterm infants with and without history of bronchopulmonary dysplasia (BPD), before and after the application of inspiratory flow resistive loading.
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Management of surgical problems in children on home invasive mechanical ventilation Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Ergun Ergun, Gulnur Gollu
The management of surgical problems in children on home invasive mechanical ventilation (HIMV) requires a comprehensive and multidisciplinary approach. HIMV is a critical intervention for children with chronic respiratory failure, as it allows them to live at home with their families while receiving life-sustaining ventilatory support. However, the long-term use of HIMV exposes these children to potential
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Machine learning models to evaluate mortality in pediatric patients with pneumonia in the intensive care unit Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Siang-Rong Lin, Jeng-Hung Wu, Yun-Chung Liu, Pei-Hsin Chiu, Tu-Hsuan Chang, En-Ting Wu, Chia-Ching Chou, Luan-Yin Chang, Fei-Pei Lai
This study aimed to predict mortality in children with pneumonia who were admitted to the intensive care unit (ICU) to aid decision-making.
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A new vision: Integration of ophthalmology services into an interdisciplinary pediatric cystic fibrosis clinic model Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Brittany A. Wright, Lindsay M. De Andrade, Alina V. Dumitrescu, Scott A. Larson, Rebecca L. Weiner, Pavlina S. Kemp
Elexacaftor/tezacaftor/ivacaftor (ETI, Trikafta®) was approved in October 2019 and works to correct the underlying defect of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.1, 2 Age expansions for CFTR modulators have allowed us to prescribe ivacaftor monotherapy (Kalydeco®), ETI, and lumacaftor/ivacaftor (Orkambi®), to patients with eligible CFTR mutations at 1 month, 2 years
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The impact of undergoing elective pediatric lung resection during respiratory syncytial virus peak season on patient outcomes: A nationwide retrospective analysis Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Pooja S. Salvi, Joseph K. Canner, Barbara Coons, Robert A. Cowles, Abigail J. Engwall-Gill, Shaun M. Kunisaki, Annalise B. Penikis, Eric Schneider, Shelby R. Sferra, Daniel G. Solomon
Observational data to support delaying elective pediatric thoracic surgery during peak respiratory viral illness season is lacking. This study evaluated whether lung surgery during peak viral season is associated with differences in postoperative outcomes and resource utilization.
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Acute exposure to pollen and airway inflammation in adolescents Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Nicholas J. Nassikas, Heike Luttmann-Gibson, Sheryl L. Rifas-Shiman, Emily Oken, Diane R. Gold, Mary B. Rice
Pollen exposure is known to exacerbate allergic asthma and allergic rhinitis symptoms, yet few studies have investigated if exposure to pollen affects lung function or airway inflammation in healthy children.
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Epidemiological shifts in bronchiolitis patterns and impact of the COVID-19: A two-season comparative study Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Santiago Presti, Sara Manti, Carmela Gammeri, Giuseppe F. Parisi, Maria Papale, Salvatore Leonardi
Bronchiolitis is a common lower respiratory tract infection (LRTI) affecting infants and young children. Respiratory syncytial virus (RSV) has historically been the primary causative agent, but other viruses also contribute to the LRTI epidemiology. Recent changes in epidemiology and clinical patterns due to the coronavirus disease 2019 (COVID-19) pandemic have raised concerns. This study aims to analyze
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Impulse oscillometry bronchodilator response in preschool children Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Aniello Meoli, Jordis Trischler, Martin Hutter, Melanie Dressler, Susanna Esposito, Katharina Blümchen, Stefan Zielen, Johannes Schulze
In preschoolers, performing an acceptable spirometry and measuring bronchodilator response (BDR) is challenging; in this context, impulse oscillometry (IOS) represents a valid alternative. However, more studies on the standardization of BDR for IOS in young children are required.
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Diaphragm atrophy during invasive mechanical ventilation is related to extubation failure in preterm infants: An ultrasound study Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Stefano Nobile, Annamaria Sbordone, Nicola Salce, Maria Letizia Patti, Alessandro Perri, Simona Fattore, Giorgia Prontera, Lucia Giordano, Milena Tana, Giovanni Vento
Diaphragm dysfunction is associated with poor outcomes in critically ill patients. Ventilator-induced diaphragmatic dysfunction (VIDD), including diaphragm atrophy (DA), is poorly studied in newborns. We aimed to assess VIDD and its associations in newborns.
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When lungs and weights tell different stories Pediatr. Pulmonol. (IF 3.1) Pub Date : 2024-02-14 Sanjiv Godse, Eliaz Brumer, Tuba Kockar Kizilirmak, Craig Canapari, Cicero Silva, Raffaella Morotti, Yong-Hui Jiang, Lauren Jeffries, Laura Chen, Sherin Panacherry
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.