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Analysis of global gene expression using RNA-sequencing reveals novel mechanism of Yanghe Pingchuan decoction in the treatment of asthma BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-18 Lingyu Pan, Bangfu He, Chunxia Gong, Yehong Sun, Xianchun Duan, Yanquan Han, Jijun Chu, Yongzhong Wang
Yanghe Pingchuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma. An ovalbumin-induced asthma model in rats was created. Staining (hematoxylin and eosin, Masson) was used to evaluate the treatment effect of YPD. RNA-sequencing was carried out to analyze global
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Clinical characteristics and outcome of lung cancer in patients with fibrosing interstitial lung disease BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Soo Jin Han, Hyeon Hwa Kim, Dong-gon Hyun, Wonjun Ji, Chang-Min Choi, Jae Cheol Lee, Ho Cheol Kim
Lung cancer (LC) is an important comorbidity of interstitial lung disease (ILD) and has a poor prognosis. The clinical characteristics and outcome of each ILD subtype in LC patients have not been sufficiently investigated. Therefore, this study aimed to evaluate the difference between idiopathic pulmonary fibrosis (IPF) and non-IPF ILD as well as prognostic factors in patients with ILD-LC. The medical
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Comparison of the yield of two tuberculosis screening approaches among household contacts in a community setting of Silti Zone, Central Ethiopia: a prospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Habtamu Milkias Wolde, Betselot Zerihun, Waganeh Sinshaw, Delenasaw Yewhalaw, Gemeda Abebe
Household contacts of tuberculosis (TB) patients are at a greater risk of infection and developing TB as well. Despite recommendations to actively screen such high-risk groups for TB, it is poorly implemented in Ethiopia. A community-based household contact screening was conducted to compare the yield of two different screening approaches and to identify factors associated with TB occurrence. Smear-positive
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Patient education needs in severe asthma, a pilot study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Rodolphe Laurence, Julien Ancel, Maëva A. Devilliers, Sophie Carre, Sandra Dury, Valérian Dormoy, Gaëtan Deslée, Jeanne-Marie Perotin
Severe asthma is characterized by frequent exacerbations, altered lung function, and impaired quality of life. Tailored patient education allows for the improvement of both asthma management and quality of life. Our study aimed to assess the needs of severe asthma patient in therapeutic education, according to previous therapeutic patient education background and asthma phenotype. Consecutive patients
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Agreement between self-reported and registered age at asthma diagnosis in Finland BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Elias Nurmi, Iida Vähätalo, Pinja Ilmarinen, Heidi Andersén, Leena E. Tuomisto, Anssi Sovijärvi, Helena Backman, Lauri Lehtimäki, Linnea Hedman, Arnulf Langhammer, Bright I. Nwaru, Päivi Piirilä, Hannu Kankaanranta
In epidemiological studies, the age at asthma onset is often defined by patients’ self-reported age at diagnosis. The reliability of this report might be questioned. Our objective was to evaluate the agreement between self-reported and registered age at asthma diagnosis and assess features contributing to the agreement. As part of the FinEsS respiratory survey in 2016, randomly selected population
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Bronchodilator reversibility testing in morbidly obese non-smokers: a comparative study– few concerns BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Divya Balan, Manish R Shetty, Manu K Mohan
This is a letter in response to an article by Ahmed et al., which concluded that in comparison to salbutamol, Fluticasone/salmeterol combination increases FEV1, FEV1% of predicted, and FEV1/FVC ratio, however it did not offer novel insights, as both agents met the 12%- and 200-mL reversibility benchmarks and Concerns about incorporating a combination medication that includes an inhaled corticosteroid
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Retraction Note: Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 Yilin Zhang, Yihong Gan, Hong Zhang
Retraction Note: BMC Pulmonary Medicine (2023) 23:376 https://doi.org/10.1186/s12890-023-02673-4 The Editor has retracted this article because, owing to an administration error, it was published before the peer review process had been undertaken. Post-publication peer review has concluded that the article does not present an a priori hypothesis and the methodology is not adequately described. In addition
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IRF4-mediated Treg phenotype switching can aggravate hyperoxia-induced alveolar epithelial cell injury BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-15 He Langyue, Zhu Ying, Jiang Jianfeng, Zhu Yue, Yao Huici, Lu Hongyan
Bronchopulmonary dysplasia (BPD) is characterized by alveolar dysplasia, and evidence indicates that interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various inflammatory lung diseases. Nonetheless, the significance and mechanism of IRF4 in BPD remain unelucidated. Consequently, we established a mouse model of BPD through hyperoxia exposure, and ELISA was employed to measure
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Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-13 Fangjun Chen, Chutong Lin, Xing Gu, Yingze Ning, Huayu He, Guangliang Qiang
Previous observational research showed a potential link between physical activities such as walking and the risk of lung cancer. However, Mendelian randomization (MR) studies suggested there was no association between moderate to vigorous physical activity and lung cancer risk. We speculated that specific physical activities may be associated with lung cancer risk. Consequently, we conducted an MR
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The efficacy of extracellular vesicles for acute lung injury in preclinical animal models: a meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-13 Xuefeng Zhang, Zongyong Cheng, Menghao Zeng, Zhihui He
With the increasing research on extracellular vesicles (EVs), EVs have received widespread attention as biodiagnostic markers and therapeutic agents for a variety of diseases. Stem cell-derived EVs have also been recognized as a new viable therapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To assess their efficacy, we conducted a meta-analysis of existing preclinical
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The total-breath method yields higher values of DLCO and TLC than the conventional method BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-13 Rudolf A. Jörres, Christian Buess, Andreas Piecyk, Bruce Thompson, Sanja Stanojevic, Helgo Magnussen
The 2017 ATS/ERS technical standard for measuring the single-breath diffusing capacity (DLCO) proposed the “rapid-gas-analyzer” (RGA) or, equivalently, “total-breath” (TB) method for the determination of total lung capacity (TLC). In this study, we compared DLCO and TLC values estimated using the TB and conventional method, and how estimated TLC using these two methods compared to that determined by
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Long-term pulmonary outcomes of young adults born prematurely: a Polish prospective cohort study PREMATURITAS 20 BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-12 Katarzyna Walicka-Serzysko, Magdalena Postek, Urszula Borawska-Kowalczyk, Katarzyna Szamotulska, Piotr Kwaśniewicz, Krystyna Polak, Ewa Mierzejewska, Dorota Sands, Magdalena Rutkowska
The long-term consequences of prematurity are often not sufficiently recognized. To address this gap, a prospective cohort study, which is a continuation of the multicenter Polish study PREMATURITAS, was conducted, utilizing unique clinical data from 20 years ago. The main goal was to evaluate lung function, detect any structural abnormalities using lung ultrasound, and assess psychological well-being
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Characteristics, treatments, in-hospital and long-term outcomes among inpatients with acute exacerbation of chronic obstructive pulmonary disease in China: sex differences in a large cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-11 Jiarui Zhang, Qun Yi, Chen Zhou, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Xiufang Xie, Pinhua Pan, Mengqiu Yi, Lina Cheng, Hui Zhou, Liang Liu, Adila Aili, Yu Liu, Lige Peng, Jiaqi Pu, Haixia Zhou
Data related to the characteristics, treatments and clinical outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in China are limited, and sex differences are still a neglected topic. The patients hospitalized for AECOPD were prospectively enrolled from ten medical centers in China between September 2017 and July 2021. Patients from some centers received follow-up
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Exploring the association between ultra-processed foods and COPD: a case-control study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-08 Zahra Salehi, Hanieh Malmir, Batoul Ghosn, Shokouh Onvani, Mohammad Emami Ardestani, Awat Feizi, Ahmad Esmaillzadeh, Leila Azadbakht
While it is known that the overconsumption of ultra-processed foods (UPFs) is associated with a heightened risk of respiratory ailments, the specific effects of UPF intake on COPD remain unclear. This study was designed to explore the potential link between COPD and the consumption of UPFs among adult individuals in Iran. In this hospital-based case-control study conducted at Alzahra University Hospital
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Sarcoid-like reaction and hypothyroidism induced by PD-1 inhibitor treatment in metastatic renal cell carcinoma: a case report and literature review BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-08 Oadi N. Shrateh, Yazan Abugharbieh, Yousef Abu Asbeh, Hani hour, Iyad Awad, Sami bannoura
Pembrolizumab is among the approved treatments for a variety of cancer types, including clear cell renal cell carcinoma (ccRCC). It has contributed to enhancing the prognosis of renal cell carcinoma. However, it is essential to be aware of the numerous potential immune-related side effects associated with its use. A 69-year-old patient with a history of metastatic renal cell carcinoma has been undergoing
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Respiratory fit test panel representing population of Malaysia BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-07 Yin Cheng Lim, Shahrul Aiman Soelar, Ameerah Su’ad Abdul Shakor¹, Nadia Mohamad, Muhammad Alfatih Pahrol, Rohaida Ismail, Mahmoud Danaee, Rafiza Shaharudin
The existing respiratory fit test panels (RFTPs) are based on Bivariate and Principal Component Analysis (PCA) which utilise American and Chinese head and facial dimensions. As RFTPs based on local facial anthropometric data for Malaysia are not available, this study was conducted with the aim to develop new RFTPs using Malaysian data. A cross-sectional study was conducted across Malaysia among 3,324
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Severe megaloblastic anemia in a patient with advanced lung adenocarcinoma during treatment with erlotinib: a case report and literature review BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-06 Xin Yan, Jingxian Kong, Jiacheng Wang, Caixia Wang, Hongchang Shen
Erlotinib is a first-generation, tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) used for the treatment patients with NSCLC. Erlotinib is considered as a safe and effective treatment option, with generally good tolerance. Diarrhea and rash are the most common side effects, and more rare side effects appear in long-term real-world applications. Severe erlotinib related megaloblastic
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Effects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-06 Liying Zhao, Shuang Lv, Qian Xiao, Yuan Zhang, Wenbo Yi, Yu Bai, Kangping Lu, Kevin C. Bermea, Jessica Semel, Xiaomei Yang, Jianbo Wu
A significant reduction in regional cerebral oxygen saturation (rSO2) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO2, pulmonary oxygenation, and hemodynamics during OLV. Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned
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Chronic obstructive pulmonary disease burden, grades and erythrocytosis at a tertiary hospital in western Uganda BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-06 Amon Banturaki, Dalton Kambale Munyambalu, Dickson Kajoba, Verah Bella Onchoke, Alina Peris, Prosper Ryamugwiza, Jacinto Amandua, Kingsley Akaba
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide among people over 40 years of age, and erythrocytosis is one of the major complications associated with increased mortality among COPD patients. The study aimed to determine the proportion of COPD, associated factors, and the burden of erythrocytosis among COPD participants. A descriptive cross-sectional study
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Hospital admission rates and related outcomes among adult Aboriginal australians with bronchiectasis – a ten-year retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-06 Timothy Howarth, Claire Gibbs, Subash S. Heraganahally, Asanga Abeyaratne
This study assessed hospitalisation frequency and related clinical outcomes among adult Aboriginal Australians with bronchiectasis over a ten-year study period. This retrospective study included patients aged ≥ 18 years diagnosed with bronchiectasis between 2011 and 2020 in the Top End, Northern Territory of Australia. Hospital admissions restricted to respiratory conditions (International Classification
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Age at menarche and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-06 Jiaqi Cao, Yazhou Ma, Wei Zhao, Chunlai Feng
Sex difference in the incidence rate of idiopathic pulmonary fibrosis (IPF) indicates that estrogen has a certain protective effect on the disease. Nevertheless, there is a dearth of study investigating the association between factors pertaining to endogenous estrogen exposure level, such as age at menarche (AAM) in women, and IPF. Our study intended to employ Mendelian randomization (MR) method to
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Contribution of small airway inflammation to the development of COPD BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Li Li, Ying Gong, Dongni Hou, Yijun Song, Jing Bi, Miao Li, Junjie Han, Yuanlin Song, Jun She
Little attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whether small airway inflammation (SAI) was the risk for the development of COPD. A total of 1062 patients were enrolled and analyzed in the study. The
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A case with multiple nodules and mucosal oedema of the trachea and both bronchi induced by IgG4-related disease BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Atsushi Torii, Kahori Oshima, Akari Iwakoshi, Masahide Oki
IgG4-related disease is a systemic fibroinflammatory disease that is mainly seen in older men, and involves multiple organs, such as the pancreas and lungs. However, 75% of patients with IgG4-related lung disease are asymptomatic (if they are symptomatic, they mainly complain of nasal congestion, rhinorrhoea, chest pain, and cough) and are incidentally diagnosed through chest computed tomograph. Although
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Proportions and risk factors of chronic obstructive pulmonary disease and preserved ratio impaired spirometry, and association with small airway disease, in the positive screening older population from China: a cross-sectional study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Le Sang, Xia Gong, Yunlei Huang, Jian Sun
Early diagnosing Chronic Obstructive Pulmonary Disease (COPD) is relatively difficult. Therefore, the concepts of preserved ratio impaired spirometry (PRISm) and small airway disease (SAD) were proposed to achieve early diagnosis for COPD. Besides, the occurrence of COPD is positively related to age. However, the relationship among COPD, PRISm, and SAD still requires clarification. Thus, we estimated
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Opportunistic screening for COPD among socially marginalized patients BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Nina Brünés, Mette Bendtz Lindstroem, Charlotte Suppli Ulrik, Ove Andersen, Marianne Lisby, Nina Skavlan Godtfredsen, Tina Leth Hansen, Charlotta Pisinger, Vibeke Graven, Kristoffer Marsaa, Laura Hohwü Thomsen
Chronic obstructive pulmonary disease (COPD) is a common disease associated with premature death. Tobacco exposure is the main risk factor, but lower socioeconomic status, early life insults, and occupational exposures are also important risk factors. Socially marginalized people, facing homelessness, substance use disorder, and mental illness, are likely to have a higher risk of developing COPD, and
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Identification of biomarkers and pathways for the SARS-CoV-2 infections in obstructive sleep apnea patients based on machine learning and proteomic analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Hong Luo, Jisong Yan, Rui Gong, Dingyu Zhang, Xia Zhou, Xianguang Wang
The prevalence of obstructive sleep apnea (OSA) was found to be higher in individuals following COVID-19 infection. However, the intricate mechanisms that underscore this concomitance remain partially elucidated. The aim of this study was to delve deeper into the molecular mechanisms that underpin this comorbidity. We acquired gene expression profiles for COVID-19 (GSE157103) and OSA (GSE75097) from
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Association between admission heart rate and in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-05 Ruoqing Zhou, Dianzhu Pan
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure (RF) is a chronic respiratory disease that seriously endangers human health. This study aimed to specifically evaluate the relationship between admission heart rate (AHR) and in-hospital mortality in patients with combined AECOPD and RF to better inform clinical treatment. This retrospective cohort
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Attributable mortality of ARDS among critically ill patients with sepsis: a multicenter, retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-04 Dong-Hui Wang, Hui-Miao Jia, Xi Zheng, Xiu-Ming Xi, Yue Zheng, Wen-Xiong Li
Both sepsis and acute respiratory distress syndrome (ARDS) are common severe diseases in the intensive care unit (ICU). There is no large-scale multicenter study to clarify the attributable mortality of ARDS among septic patients. This study aimed to evaluate the excess mortality of ARDS in critically ill patients with sepsis. The data were obtained from a multicenter, prospective cohort study in 18
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Effect of furosemide in the treatment of high-altitude pulmonary edema BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-04 Dava Tenzing, Pianduo Suolang, Deji Gesang, Duoji Suolang, Gaozhan Duan, Wangmu Ciren, Yihui Wang, Tongtian Ni
High-altitude pulmonary edema (HAPE) refers to the onset of breathlessness, cough, and fever at rest after arriving at high altitudes. It is a life-threatening illness caused by rapid ascent to high altitudes. Furosemide is controversial in HAPE treatment but is routinely used in China. Further research is needed to assess its efficacy and impact on HAPE management and prognosis. The aim of this study
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The accuracy of electromagnetic navigation bronchoscopy compared to fluoroscopy in navigation of transbronchial lung cryobiopsy in patients with interstitial lung disease BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-04 Shiyao Wang, Jinmi Yang, Sa Luo, Jing Geng, Yanhong Ren, Ling Zhao, Min Liu, Dan Wang, Ying Li, Zheng Tian, Wei Liu, Guowu Zhou, Huaping Dai
Safely implementing transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD) requires accurate navigation. Traditional fluoroscopy falls short in reducing the risk of post-procedure pneumothorax. The potential of electromagnetic navigation bronchoscopy (ENB) as a more precise navigation method warrants further exploration. A prospective cohort study was conducted on ILD
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Comparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-04 Xu Liu, Qingfeng Zhang, Hao Chen, Yueying Hao, Jingyi Zhang, Shiqian Zha, Beini Zhou, Yaohua Yi, Rui Xiao, Ke Hu
Mycoplasma pneumoniae infections have increased in China recently, causing some evidence of familial clustering. The purpose of this study was to compare the clinical features of parents and children in cases of familial clustering of Mycoplasma pneumoniae infection. A retrospective analysis was performed on the cases of familial clustering of Mycoplasma pneumoniae infection, and the clinical characteristics
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Distribution and characteristics of malignant tumours by lung lobe BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-04 Yngvar Nilssen, Odd Terje Brustugun, Lars Fjellbirkeland, Åslaug Helland, Bjørn Møller, Sissel Gyrid Freim Wahl, Steinar Solberg
The main focus on the characteristics of malignant lung tumours has been the size, position within the lobe, and infiltration into neighbouring structures. The aim of this study was to investigate the distribution and characteristics of malignant tumours between the lung lobes and whether the diagnosis, treatment, and outcome differed based on location. This study is based on 10,849 lung cancer patients
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Clinical trends among patients with asthma hospitalized for COVID-19 based on data from a nationwide database: an observational study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-02 Akinari Tsukada, Junko Terada-Hirashima, Jin Takasaki, Hiroshi Nokihara, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama
While the prevalence of severe cases and mortality rate of coronavirus disease 2019 (COVID-19) appear to be reducing, the clinical characteristics and severity of hospitalized patients with asthma and COVID-19 remain largely unknown. This study aimed to examine the association of asthma with COVID-19 severity and mortality risk. Data from the Japanese COVID-19 Registry Database were used to investigate
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The impact of obesity on ventilator-associated pneumonia, a US nationwide study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-02 Mohamad El Labban, Michella Abi Zeid Daou, Hiba Smaily, Abbas Hammoud, Ghandi Hassan, Syed Khan, Imad Bou Akl
Ventilator-associated pneumonia (VAP) is one of the leading causes of mortality in patients with critical care illness. Since obesity is highly prevalent, we wanted to study its impact on the outcomes of patients who develop VAP. Using the National Inpatient Sample (NIS) database from 2017 to 2020, we conducted a retrospective study of adult patients with a principal diagnosis of VAP with a secondary
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Effects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-01 Jennifer A. Zader, Rudolf A. Jörres, Imke Mayer, Peter Alter, Robert Bals, Henrik Watz, Pontus Mertsch, Klaus F. Rabe, Felix Herth, Franziska C. Trudzinski, Tobias Welte, Hans-Ulrich Kauczor, Jürgen Behr, Julia Walter, Claus F. Vogelmeier, Kathrin Kahnert
Randomized controlled trials described beneficial effects of inhaled triple therapy (LABA/LAMA/ICS) in patients with chronic obstructive pulmonary disease (COPD) and high risk of exacerbations. We studied whether such effects were also detectable under continuous treatment in a retrospective observational setting. Data from baseline and 18-month follow-up of the COPD cohort COSYCONET were used, including
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Prevalence, risk factors, and clinical characteristics of pulmonary embolism in patients with acute exacerbation of COPD in Plateau regions: a prospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-27 Chenlu Yang, Yajun Tuo, Xuefeng Shi, Jie Duo, Xin Liu, Fang Zhang, Xiaokai Feng
To investigate pulmonary thromboembolism (PE) in acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) patients in plateau regions, we performed a prospective cohort study to evaluate the prevalence, risk factors and clinical characteristics of PE in the cohort of hospitalized patients at high altitude. We did a prospective study with a total of 636 AE-COPD patients in plateau regions
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Artificial intelligence-based model for predicting pulmonary arterial hypertension on chest x-ray images BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-27 Shun Imai, Seiichiro Sakao, Jun Nagata, Akira Naito, Ayumi Sekine, Toshihiko Sugiura, Ayako Shigeta, Akira Nishiyama, Hajime Yokota, Norihiro Shimizu, Takeshi Sugawara, Toshiaki Nomi, Seiwa Honda, Keisuke Ogaki, Nobuhiro Tanabe, Takayuki Baba, Takuji Suzuki
Pulmonary arterial hypertension is a serious medical condition. However, the condition is often misdiagnosed or a rather long delay occurs from symptom onset to diagnosis, associated with decreased 5-year survival. In this study, we developed and tested a deep-learning algorithm to detect pulmonary arterial hypertension using chest X-ray (CXR) images. From the image archive of Chiba University Hospital
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Improving the diagnosis of active tuberculosis: a novel approach using magnetic particle-based chemiluminescence LAM assay BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-27 Yan Li, Zhiwei Ru, Hongxia Wei, Ming Wu, Guihua Xie, Jianrong Lou, Xiang Yang, Xilin Zhang
Tuberculosis (TB) is a significant global health concern, given its high rates of morbidity and mortality. The diagnosis using urine lipoarabinomannan (LAM) primarily benefits HIV co-infected TB patients with low CD4 counts. The focus of this study was to develop an ultra-sensitive LAM assay intended for diagnosing tuberculosis across a wider spectrum of TB patients. To heighten the sensitivity of
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A dynamic nomogram predicting symptomatic pneumonia in patients with lung cancer receiving thoracic radiation BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-26 Yawen Zha, Jingjing Zhang, Xinyu Yan, Chen Yang, Lei Wen, Minying Li
The most common and potentially fatal side effect of thoracic radiation therapy is radiation pneumonitis (RP). Due to the lack of effective treatments, predicting radiation pneumonitis is crucial. This study aimed to develop a dynamic nomogram to accurately predict symptomatic pneumonitis (RP ≥ 2) following thoracic radiotherapy for lung cancer patients. Data from patients with pathologically diagnosed
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Eosinophilic bronchiectasis increases length and cost of hospitalization: a retrospective analysis in a hospital of southern China from 2012 to 2020 BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-26 Chengcheng Lei, Zhimin Zeng, Fengjia Chen, Yubiao Guo, Yangli Liu
The concept of eosinophilic bronchiectasis has received clinical attention recently, but the association between blood eosinophil count (BEC) and hospital characteristics has rarely been reported yet. We aim to investigate the clinical impact of BEC on patients with acute bronchiectasis exacerbation. A total of 1332 adult patients diagnosed with acute exacerbation of bronchiectasis from January 2012
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Primary endobronchial melanoma: a case report and clinical management indications BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-24 Emanuela Barisione, Andrea Boutros, Marco Mora, Francesco Spagnolo, Enrica Teresa Tanda, Carlo Genova, Elena Tagliabue
While cutaneous melanomas are well-documented, primary melanoma of the lung (PMML), particularly with endobronchial origin, remains rare and poorly characterized. This case report addresses gaps in understanding by presenting a comprehensive case of a 71-year-old male with primary endobronchial melanoma and conducting a systematic review of PMML cases. The patient, a former smoker, presented with dyspnea
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Chemotherapy versus personalized therapy for EGFR mutant lung adenocarcinoma resistance to EGFR-tyrosine kinase inhibitors: a retrospective dual-center study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-24 Kan Jiang, Lin Wu, Xinlong Zheng, Yiquan Xu, Qian Miao, Xiaobin Zheng, Longfeng Zhang, Cheng Huang, Gen Lin
Advanced lung adenocarcinoma patients often develop resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), leaving uncertainties regarding subsequent treatment strategies. Although personalized therapy targeting individual acquired resistances (ARs) shows promise, its efficacy has not been systematically compared with platinum-containing doublet chemotherapy, a widely accepted treatment after EGFR-TKIs
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Study on predictive models for swallowing risk in patients with AECOPD BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-23 Shuyun Xiong, You Zhou, Wenfeng He, Jinling Zhu, Wenfang He, Meizhu Ding, Dongxu Si
Dysphagia is considered a complication in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, AECOPD may have risk factors for dysphagia. Through a cross-sectional study, which included 100 patients with AECOPD. General information, Pulmonary function, COPD assessment test (CAT) and modified Medical Research Council (mMRC) were collected by questionnaire. The
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Identification and treatment of persistent small airway dysfunction in paediatric patients with asthma: a retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-23 Lulu Zhang, Zhou Fu, Hua Deng, Qin Xie, Wenjie Wu
Asthma is a common respiratory disease. In asthma, the small airways have more intensive inflammation and prominent airway remodelling, compared to the central airways. We aimed to investigate the predictive value of risk factors and the fractional concentration of exhaled nitric oxide (FeNO) for persistent small airway dysfunction (p-SAD), and compare the effects of different treatment modalities
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Synchronous double primary small cell lung cancer and invasive ductal breast carcinoma: a case report BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-22 Junqing Gan, Meiyue Liu, Fei Liu, Junxiu Wen, Wenjuan Fu, Jinghao Jia
Although lung and breast cancers are common malignancies, the occurrence of primary synchronous neoplasms involving these organs has been rarely reported in literature. A 75-year-old female patient presented at a local hospital with a ten-day history of dizziness and slurred speech. A CT contrast-enhanced scan revealed a 4.2 cm mass in the lower lobe of the right lung and a 3.8 cm space-occupying lesion
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Comparison of high-flow nasal cannula oxygenation and non-invasive ventilation for postoperative pediatric cardiac surgery: a meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-21 Si-Jia Zhou, Xiu-Hua Chen, Ying-Ying Liu, Qiang Chen, Yi-Rong Zheng, Qi-Liang Zhang
To evaluate the efficacy of high-flow nasal cannula oxygenation (HFNC) versus non-invasive ventilation (NIV) in pediatric patients post-congenital heart surgery (CHS) through a meta-analysis. A comprehensive literature search was conducted across the Chinese biomedical literature database, Vip database, CNKI, Wanfang, PubMed, Embase, Cochrane Library, and Web of Science until December 20, 2022. We
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Case report of a novel alpha1-antitrypsin null variant in Türkiye: Q0RİZE BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-21 Dilek Karadoğan, Ünal Şahin, Bettina Dreger, Laura Grandoso, Lourdes Osaba
Alpha1-antitrypsin (AAT) is a serine protease inhibitor that serves as a counterbalance to the activity of elastases, e.g., neutrophil elastase in lung tissue. AAT deficiency (AATD) is a rare disorder usually arising from mutations to the SERPINA1 gene that codes for AAT. The most common AATD alleles are S and Z which produce ~ 40% and ~ 90% reductions in serum AAT, respectively. Rare genetic variants
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Clinical course of COPD patients with exercise-induced elevation of pulmonary artery pressure or less severe pulmonary hypertension presenting with respiratory symptoms and the impact of bosentan intervention—prospective, single-center, randomized, parallel-group study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-17 Takeru Kashiwada, Yosuke Tanaka, Toru Tanaka, Tetsuya Okano, Yoshinobu Saito, Masahiro Seike, Mitsunori Hino, Hiroshi Kimura, Akihiko Gemma
The data on bosentan were lacking for the treatment of exercise-induced elevation of pulmonary artery pressure (eePAP) or less severe PH in COPD. This study was conducted to investigate long-term efficacy and safety of bosentan for the treatment of eePAP or less severe PH in COPD. COPD patients diagnosed at this hospital as having COPD (WHO functional class II, III or IV) with eePAP or less severe
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Efficacy of bevacizumab through an indwelling pleural catheter in non-small cell lung cancer patients with symptomatic malignant pleural effusion BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-16 Hao Zeng, Yuanyuan Zhang, Sihan Tan, Qin Huang, Xin Pu, Panwen Tian, Yalun Li
Several studies have indicated that intrapleural infusion of bevacizumab is an effective treatment for non-small cell lung cancer (NSCLC) with malignant pleural effusion (MPE). However, the impact of bevacizumab administered through an indwelling pleural catheter (IPC) on the prognosis of these patients is unknown. Consecutive advanced NSCLC patients with symptomatic MPE receiving an IPC alone or bevacizumab
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The effect of incentive spirometry in perioperative patients with lung cancer—a systematic review and meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-15 Yan Liang, Shaolin Chen, Jiamei Song, Ting Deng, Jinfen Yang, Yangyang Long, Lorna Kwai Ping Suen, Xu Luo
Incentive spirometry (IS) as a routine respiratory therapy during the perioperative period has been widely used in clinical practice. However, the impact of IS on patients with perioperative lung cancer remains controversial. This review aimed to evaluate the efficacy of IS in perioperative pulmonary rehabilitation for patients with lung cancer. Cochrane Library, PubMed, Web of Science, Ovid, CINAHL
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The effectiveness and pharmacoeconomic study of using different corticosteroids in the treatment of hypersensitivity pneumonitis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-15 Marwa G. Elhennawy, Yosri Akl, Maggie Abbassi, Nirmeen A. Sabry
Interstitial lung diseases (ILDs) are caused by inflammation and/or fibrosis of alveolar walls resulting in impaired gas exchange. Hypersensitivity pneumonitis (HP) is the third most common type of ILDs. Corticosteroids are the mainstay treatment for HP. The use of intramuscular (IM) betamethasone or intravenous (IV) dexamethasone as weekly pulse doses has shown higher benefit than daily oral prednisolone
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Bronchoscopic lung volume reduction by instillation of fibrinogen and thrombin in COPD patients with homogenous emphysema BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-14 Dina Abd El Wahab El Gohary, Mohamed Adel Eltomey, Ahmed Shawky Mohamed, Amgad Abd El Raouf Farahat, Ayman Hassan Abd El Zaher
The new endobronchial therapy called biological lung volume reduction (BioLVR) involves using a rapid polymerizing sealant to block off the most emphysematous portions of the lungs. The primary mechanism of action is resorption atelectasis, which is then followed by inflammation and remodeling of the airspace. The remodeling process will result in the formation of scars, leading to the contraction
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Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-14 Jiang Wu, Guang Fu, Chao Luo, Liang Chen, Quanxing Liu
Lung adenocarcinoma (LUAD) has high morbidity and mortality. Despite substantial advances in treatment, the prognosis of patients with LUAD remains unfavorable. The ceRNA axis has been reported to play an important role in the pathogenesis of LUAD. In addition, cuproptosis is considered an important factor in tumorigenesis. The expression of CBX2 has been associated with the development of multiple
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Assessment of clinical relevance of antigen improves diagnostic accuracy of hypersensitivity pneumonitis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-14 Yuki Iijima, Masaru Ejima, Takashi Yamana, Shiro Sonoda, Sho Shibata, Tsuyoshi Shirai, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi, Takuya Adachi, Mio Mori, Susumu Kirimura, Tatsuhiko Anzai, Kunihiko Takahashi, Yasunari Miyazaki
Exposure assessment is integral to the diagnosis of hypersensitivity pneumonitis (HP). Although the clinical relevance of exposed antigens is essential for the assessment, many of the previous guidelines or reports have only evaluated simple exposure histories or immunological tests. To overcome this problem, the Exposure Assessment Form (EAF) was developed as an assessment tool for classifying the
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Understanding changes in pulmonary function and functional status in breast cancer patients after systemic chemotherapy and radiotherapy: a prospective study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-14 Alper Tuğral, Zeynep Arıbaş, Murat Akyol, Yeşim Bakar
Respiratory complications in breast cancer (BC) patients after chemotherapy (CT) and radiotherapy (RT) have been well acquainted and these complications should be investigated to prevent secondary problems and/or improve BC patients’ clinical outcomes. Therefore, this study aimed to assess the potential acute effect of systemic chemotherapy and radiotherapy on respiratory function and functional status
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Development and validation of a prospective study to predict the risk of readmission within 365 days of respiratory failure: based on a random survival forest algorithm combined with COX regression modeling BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-14 Zhongxiang Liu, Zhixiao Sun, Hang Hu, Yuan Yin, Bingqing Zuo
There is a need to develop and validate a widely applicable nomogram for predicting readmission of respiratory failure patients within 365 days. We recruited patients with respiratory failure at the First People’s Hospital of Yancheng and the People’s Hospital of Jiangsu. We used the least absolute shrinkage and selection operator regression to select significant features for multivariate Cox proportional
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Correction: Understanding the effects of Haemophilus influenzae colonization on bronchiectasis: a retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-13 Seo-Hee Yang, Myung Jin Song, Yeon Wook Kim, Byoung Soo Kwon, Sung Yoon Lim, Yeon-Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee, Hyung-Jun Kim
BMC Pulmonary Medicine (2023) 24:7 https://doi.org/10.1186/s12890-023-02823-8 Following publication of the original article [1], the authors flagged the following two concerns: Affiliation 3 should read as follows: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Veterans Hospital, 53, Jinhwangdo-ro 61-gil, Gangdong-gu, Seoul, 05368, Republic of Korea. The total
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High-sensitivity C-reactive protein level in stable-state bronchiectasis predicts exacerbation risk BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-13 Wang Chun Kwok, Kay Cheong Teo, Kui Kai Lau, James Chung-man HO
Elevation of systemic inflammatory markers were found to correlate with increased disease extent, reduced lung function and higher risk of future severe exacerbations in patients with bronchiectasis. Although a significant correlation of circulating hs-CRP levels with HRCT scores and resting oxygen saturation in patients with stable-state non-cystic fibrosis (CF) bronchiectasis was suggested, there
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Successful application of airway pressure release ventilation in a child with severe acute respiratory distress syndrome induced by trauma: a case report BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-12 Jing Su, Xin Tie, Yao Chen, Tongjuan Zou, Wanhong Yin
Trauma has been identified as one of the risk factors for acute respiratory distress syndrome. Respiratory support can be further complicated by comorbidities of trauma such as primary or secondary lung injury. Conventional ventilation strategies may not be suitable for all trauma-related acute respiratory distress syndrome. Airway pressure release ventilation has emerged as a potential rescue method
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Higher sclerostin is associated with pulmonary hypertension in pre-dialysis end-stage kidney disease patients: a cross-sectional prospective observational cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-02-10 Jonghyun Lee, Dong-Hyuk Cho, Hyeon-Jin Min, Young-Bin Son, Tae Bum Kim, Se Won Oh, Myung-Gyu Kim, Won Yong Cho, Sang-Kyung Jo, Jihyun Yang
Pulmonary hypertension (PH) is a complication of chronic kidney disease (CKD) that contributes to mortality. Sclerostin, a SOST gene product that reduces osteoblastic bone formation by inhibiting Wnt/β-catenin signaling, is involved in arterial stiffness and CKD-bone mineral disease, but scanty evidence to PH. This study explored the relationship between sclerostin and PH in CKD 5, pre-dialysis end-stage