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  • COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.
    medRxiv. Respir. Med. Pub Date : 2020-05-29
    Sarah Heili-Frades; Pablo Minguez; Ignacio Mahillo-Fernandez; Tomas Prieto-Rumeau; Antonio Herrero Gonzalez; Lorena de la Fuente; Maria Jesus Rodriguez Nieto; German Peces-Barba Romero; Mario Peces-Barba; Maria del Pilar Carballosa de Miguel; Itziar Fernandez Ormaechea; Alba Naya Prieto; Farah Ezzine de Blas; Luis Jimenez Hiscock; Cesar Perez Calvo; Arnoldo Santos; Luis Enrique Munoz Alameda; Fredeswinda

    There is limited information describing features and outcomes of patients requiring hospitalization for COVID19 disease and still no treatments have clearly demonstrated efficacy. Demographics and clinical variables on admission, as well as laboratory markers and therapeutic interventions were extracted from electronic Clinical Records (eCR) in 4712 SARS-CoV2 infected patients attending 4 public Hospitals

    更新日期:2020-05-29
  • High Resolution CHEST CT(HRCT) Evaluation in Patients Hospitalized with COVID-19 Infection
    medRxiv. Respir. Med. Pub Date : 2020-05-28
    Maulin Patel; Junad Chowdhury; Matthew Zheng; Osheen Abramian; Steven Verga; Huaqing Zhao; Nicole Patlakh; David Fleece; Nicholas Montecalvo; Gary Cohen; Maruti Kumaran; Chandra Dass; Gerard Criner

    Abstract Introduction: Currently the main diagnostic modality for COVID-19 (Coronavirus disease-2019) is reverse transcriptase polymerase chain reaction (RT-PCR) via nasopharyngeal swab which has high false negative rates. We evaluated the performance of high-resolution computed tomography (HRCT) imaging in the diagnosis of suspected COVID-19 infection compared to RT-PCR nasopharyngeal swab alone in

    更新日期:2020-05-28
  • Assessment of dispersion of airborne particles of oral/nasal fluid by high flow nasal cannula therapy
    medRxiv. Respir. Med. Pub Date : 2020-05-27
    Mark C Jermy; Callum JT Spence; Robert Kirton; Jane F O'Donnell; Natalia Kabaliuk; Sally Gaw; Yannan Jiang; Zulkhairi Zainol Abidin; Ronald L Dougherty; Philip Rowe; Anjula Mahaliyana; Amelia Gibbs; Sally Roberts

    Background Nasal High Flow (NHF) therapy delivers flows of heated humidified gases up to 60 LPM (litres per minute) via a nasal cannula. Particles of oral/nasal fluid released by patients undergoing NHF therapy may pose a cross-infection risk, which is a potential concern for treating COVID-19 patients. Methods Liquid particles within the exhaled breath of healthy participants were measured with two

    更新日期:2020-05-27
  • SARS-CoV-2 entry related genes are comparably expressed in children's lung as adults
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    Yue Tao; Ruwen Yang; Chen Wen; Jue Fan; Jing Ma; Qiao He; Zhiguang Zhao; Xinyu Song; Hao Chen; Guocheng Shi; Minzhi Yin; Nan Fang; Hao Zhang; Huiwen Chen; Xi Mo

    To explore whether the expression levels of viral-entry associated genes might contribute to the milder symptoms in children, we analysed the expression of these genes in both children and adults' lung tissues by single cell RNA sequencing (scRNA-seq) and immunohistochemistry (IHC). Both scRNA-seq and IHC analyses showed comparable expression of the key genes for SARS-CoV-2 entry in children and adults

    更新日期:2020-05-26
  • Use of High Flow Nasal Therapy to Treat Moderate to Severe Hypoxemic Respiratory Failure in COVID-19
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    Maulin Patel; Andrew Gangemi; Robert Marron; Junad Chowdhury; Ibraheem Yousef; Matthew Zheng; Nicole Mills; Lauren Tragesser; Julie Giurintano; Rohit Gupta; Matthew Gordon; Parth Rali; Gilbert D'Alonzo; David Fleece; Huaqing Zhao; Nicole Patlakh; Gerard J Criner

    Abstract Invasive mechanical has been associated with high mortality in COVID-19. Alternative therapy of High flow nasal therapy (HFNT) has been greatly debated around the world for use in COVID-19 pandemic due to concern for increased healthcare worker transmission. Methods This was a retrospective analysis of consecutive patients admitted to Temple University Hospital in Philadelphia, Pennsylvania

    更新日期:2020-05-26
  • Using HoloLens™ to reduce staff exposure to aerosol generating procedures during a global pandemic
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    John J Cafferkey; Dominic OP Hampson; Clare Ross; Angad S Kooner; Guy FJ Martin; James M Kinross

    RATIONALE: COVID-19 poses a unique challenge; caring for patients with a novel, infectious disease whilst protecting staff. Some interventions used to give oxygen therapy are aerosol generating procedures. Staff delivering such interventions require PPE and are exposed to a significant viral load resulting in sick days and even death. We aim to reduce this risk using an augmented-reality communication

    更新日期:2020-05-26
  • Impact of Proactive Integrated Care on Chronic Obstructive Pulmonary Disease
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    Patricia B. Koff; Sung-joon Min; Debora L. P. Diaz; Tammie J. Freitag; Shannon S. James; Norbert F. Voelkel; Derek J. Linderman; Fernando Diaz del Valle; Richard K. Albert; Todd M. Bull; Arne Beck; Thomas J. Stelzner; Debra P. Ritzwoller; Christine M. Kveton; Stephanie Carwin; Moumita Ghosh; Robert L. Keith; John M. Westfall; R. William Vandivier

    Background. Up to 50% of COPD patients do not receive recommended care for COPD. To address this important issue, we developed Proactive Integrated Care (Proactive iCare), a healthcare delivery model that couples integrated care with remote monitoring. Methods. We conducted a prospective, quasi-randomized clinical trial in 511 patients with advanced COPD, or a recent COPD exacerbation, to test whether

    更新日期:2020-05-26
  • Noninvasive respiratory support in acute hypoxemic respiratory failure associated with COVID-19 and other viral infections
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    Claudia Crimi; Alberto Noto; Andrea Cortegiani; Pietro Impellizzeri; Mark W Elliott; Nicolino Ambrosino; Cesare Gregoretti

    Introduction: Noninvasive respiratory support (NRS) such as noninvasive ventilation (NIV) and high flow nasal therapy (HFNT) have been used in the treatment of acute hypoxemic respiratory failure (AHRF) related to the coronavirus disease (COVID-19) and other viral infections. However, there is a lack of consensus in favor of or against NRS use due to the risks of worsening hypoxemia, intubation delay

    更新日期:2020-05-26
  • CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS FOR ICU ADMISSION OF PATIENTS WITH COVID-19 USING MACHINE LEARNING AND NATURAL LANGUAGE PROCESSING
    medRxiv. Respir. Med. Pub Date : 2020-05-26
    Jose Luis Izquierdo; Julio Ancochea; Savana COVID-19 Research Group; Joan B Soriano

    There remain many unknowns regarding the onset and clinical course of the ongoing COVID-19 pandemic. We used a combination of classic epidemiological methods, natural language processing (NLP), and machine learning (for predictive modeling), to analyse the electronic health records (EHRs) of patients with COVID-19. We explored the unstructured free text in the EHRs within the SESCAM Healthcare Network

    更新日期:2020-05-26