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High Blood Eosinophil Count at Stable State is Not Associated with Airway Microbiota Distinct Profile in COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-18 Jeanne-Marie Perotin, Anaëlle Muggeo, Quentin Lecomte-Thenot, Audrey Brisebarre, Sandra Dury, Claire Launois, Julien Ancel, Valérian Dormoy, Thomas Guillard, Gaëtan Deslee
Purpose: The heterogeneity of clinical features in COPD at stable state has been associated with airway microbiota. Blood eosinophil count (BEC) represents a biomarker for a pejorative evolution of COPD, including exacerbations and accelerated FEV1 decline. We aimed to analyse the associations between BEC and airway microbiota in COPD at stable state. Patients and Methods: Adult COPD patients at stable
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Preserved Ratio Impaired Spirometry (PRISm): A Global Epidemiological Overview, Radiographic Characteristics, Comorbid Associations, and Differentiation from Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-15 Jia Huang, Wenjun Li, Yecheng Sun, Zhutang Huang, Rong Cong, Chen Yu, Hongyan Tao
Abstract: Preserved Ratio Impaired Spirometry (PRISm) manifests notable epidemiological disparities across the globe, with its prevalence and influential factors showcasing pronounced diversities among various geographical territories and demographics. The prevalence of PRISm fluctuates considerably among regions such as Latin America, the United States, and Asian nations, potentially correlating with
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Severe COPD: Multidisciplinary Consultation to Get the Right Care at the Right Place Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-14 Pieter-Paul Hekking, Monique van Meggelen, W Johan Lie, Rogier Arnaud Sebastiaan Hoek, Dirk van Ranst, Stephan Cornelis Johan van der Kleij, Leonard Seghers, Jasper Kappen, Gert-Jan Braunstahl, Johannes In 't Veen
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Unveiling the Knowledge Frontier: A Scientometric Analysis of COPD with Sarcopenia Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-12 Jingfeng Zou, Wen Peng
Objective: Numerous articles and reviews addressing the intersection of Chronic Obstructive Pulmonary Disease (COPD) with sarcopenia have been documented. However, a significant gap exists in the literature concerning scientometric analysis in this field. This study aimed to concentrate on recent research and elucidate emerging research areas through the examination of COPD with sarcopenia. Methods:
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Automated Quantification of QT-Intervals by an Algorithm: A Validation Study in Patients with Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-12 Dario Kohlbrenner, Maya Bisang, Sayaka S Aeschbacher, Emanuel Heusser, Silvia Ulrich, Konrad E Bloch, Michael Furian
Study Objectives: To assess the diagnostic accuracy of a purpose-designed QTc-scoring algorithm versus the established hand-scoring in patients with chronic obstructive pulmonary disease (COPD) undergoing sleep studies. Methods: We collected 62 overnight electrocardiogram (ECG) recordings in 28 COPD patients. QT-intervals corrected for heart rate (QTc, Bazett) were averaged over 1-min periods and quantified
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Efficacy of Acupuncture in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-11 Chunyan Yang, Hao Tian, Guixing Xu, Qin Luo, Mingsheng Sun, Fanrong Liang
Purpose: The effect of acupuncture as adjunctive therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) was controversial. Thus, we aimed to evaluate the effects of acupuncture for treating AECOPD. Methods: Eight databases were searched from database inception to July 30, 2023. All RCTs compared acupuncture plus conventional western medicine with conventional western medicine
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The Changing and Predicted Trends in Chronic Obstructive Pulmonary Disease Burden in China, the United States, and India from 1990 to 2030 Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-08 Baojun Guo, Hui Gan, Mingshan Xue, Zhifeng Huang, Zhiwei Lin, Shiyun Li, Peiyan Zheng, Baoqing Sun
Background: This study analyzed the burden of chronic obstructive pulmonary disease (COPD) in China, the United States, and India from 1990 to 2019 and projected the trends for the next decade. Methods: This study utilized the GBD 2019 to compare the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life years (DALYs) rate, and the
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Acute Exacerbation of Chronic Obstructive Pulmonary Disease Due to Carbapenem-Resistant Klebsiella pneumoniae-Induced Pneumonia: Clinical Features and Prognostic Factors Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-07 Pengwen Ouyang, Zhijie Zhou, Chanyuan Pan, Peijuan Tang, Sheng Long, Xiangjian Liao, Qiong Liu, Liangyi Xie
Purpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is closely related to respiratory tract infection. The aim of this study was to investigate the clinical features and prognostic factors of CRKP-induced pneumonia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. Methods: A single-centre, retrospective case-control study on COPD patients hospitalized for acute
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Respiratory Oscillometry and Functional Performance in Different COPD Phenotypes Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-06 Elayne Moura Teixeira, Caroline Oliveira Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo
Purpose: Chronic obstructive pulmonary disease (COPD) phenotypes may introduce different characteristics that need to be known to improve treatment. Respiratory oscillometry provides a detailed analysis and may offer insight into the pathophysiology of COPD. In this paper, we used this method to evaluate the differences in respiratory mechanics of COPD phenotypes. Patients and Methods: This study investigated
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Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study [Letter] Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-05 Elanda Fikri
Letter for the article Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study
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The Dosing Strategy to Improve Adherence to Roflumilast in Treatment for Chronic Obstructive Lung Disease: A Systemic Review and Meta-Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-05 Jonghoo Lee, Jae-Uk Song
Background: The clinical efficacy of roflumilast, an oral phosphodiesterase-4 inhibitor, has been demonstrated in patients with severe chronic obstructive pulmonary disease (COPD). However, roflumilast has shown frequent adverse drug reactions (ADRs). This study was performed to investigate the dosing strategy that will improve adherence to roflumilast in COPD. Methods: We conducted a systematic review
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Genetic Insights into the Gut-Lung Axis: Mendelian Randomization Analysis on Gut Microbiota, Lung Function, and COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Zi-Xuan Cheng, Jian-Lan Hua, Zhi-Jun Jie, Xing-Jing Li, Jing Zhang
Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with a complex etiology involving genetic and environmental factors. The dysbiosis of gut microbiota has been implicated in COPD. Mendelian Randomization (MR) provides a tool to investigate causal links using genetic variants as instrumental variables. This study aims to employ MR analysis to explore the causal relationship
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Common Pathogeneses Underlying Asthma and Chronic Obstructive Pulmonary Disease -Insights from Genetic Studies Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Nobuyuki Hizawa
Abstract: Neither asthma nor chronic obstructive pulmonary disease (COPD) is a single disease consisting of a uniform pathogenesis; rather, they are both syndromes that result from a variety of basic distinct pathogeneses. Many of the basic pathogeneses overlap between the two diseases, and multiple basic pathogeneses are simultaneously involved at varying proportions in individual patients. The specific
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Prognostic Value of Leukocyte-Based Risk Model for Acute Kidney Injury Prediction in Critically Ill Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Min Cai, Yue Deng, Tianyang Hu
Purpose: Acute kidney injury (AKI) is a common complication of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and inflammation is the potential link between AKI and AECOPD. However, little is known about the incidence and risk stratification of AKI in critically ill AECOPD patients. In this study, we aimed to establish risk model based on white blood cell (WBC)-related indicators
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Exacerbation Burden in COPD and Occurrence of Mortality in a Cohort of Italian Patients: Results of the Gulp Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-01 Pierachille Santus, Fabiano Di Marco, Fulvio Braido, Marco Contoli, Angelo Guido Corsico, Claudio Micheletto, Girolamo Pelaia, Dejan Radovanovic, Paola Rogliani, Laura Saderi, Nicola Scichilone, Silvia Tanzi, Manlio Vella, Silvia Boarino, Giovanni Sotgiu, Paolo Solidoro
Objective: To describe the burden of moderate to severe exacerbations and all-cause mortality; the secondary objectives were to analyze treatment patterns and changes over follow-up. Design: Observational, multicenter, retrospective, cohort study with a three year follow-up period. Setting: Ten Italian academic secondary- and tertiary-care centers. Participants: Patients with a confirmed diagnosis
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Analysis of Key Genes and miRNA-mRNA Networks Associated with Glucocorticoids Treatment in Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-28 Jian-Jun Wu, Ping-An Zhang, Ming-Zhe Chen, Yi Zhang, Wei-Sha Du, Xiao-Ning Li, Guo-Chao Ji, Liang-Duo Jiang, Yang Jiao, Xin Li
Background: Some patients with chronic obstructive pulmonary disease (COPD) benefit from glucocorticoid (GC) treatment, but its mechanism is unclear. Objective: With the help of the Gene Expression Omnibus (GEO) database, the key genes and miRNA-mRNA related to the treatment of COPD by GCs were discussed, and the potential mechanism was explained. Methods: The miRNA microarray dataset (GSE76774) and
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Association Between Serum Anion Gap and Mortality in Critically Ill Patients with COPD in ICU: Data from the MIMIC IV Database Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-29 Xiaojing Chen, Qilin Yang, Li Gao, Weinan Chen, Xiaoyu Gao, Yameng Li, Liying Ao, Dejun Sun
Background: Serum anion gap (AG) has been proven to be associated with prognosis in critically ill patients. However, few studies have investigated the association between AG and all-cause mortality in critically ill patients with chronic obstructive pulmonary disease (COPD). Objective: We hypothesized that the initial AG level would predict the mortality risk in critically ill patients with COPD.
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Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-29 Yurong Xiang, Xiaobin Luo
Abstract: Most patients with chronic obstructive pulmonary disease (COPD) suffer from at least one additional, clinically relevant chronic disease. To a degree, the high global prevalence and mortality rate of COPD is closely related to its extrapulmonary effects. Moreover, the various of comorbidities of COPD and itself interact with each other, resulting in diverse clinical manifestations and individual
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Respiratory Infection Triggering Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-27 Georges Abi Abdallah, Sylvain Diop, Matthieu Jamme, Stéphane Legriel, Alexis Ferré
Background: Data are scarce on respiratory infections during severe acute exacerbation of chronic obstructive pulmonary disease (COPD). This study aimed to investigate respiratory infection patterns in the intensive care unit (ICU) and identify variables associated with infection type and patient outcome. Methods: A retrospective, single-centre cohort study. All patients admitted (2015– 2021) to our
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Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016 Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-26 Yushan Shi, Zhangmeng Xu, Shuangshuang Pu, Kanghong Xu, Yanan Wang, Chunlai Zhang
Purpose: This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States. Patients and Methods: This study was a cross-sectional analysis involving 4361 adults aged 40– 79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic
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Lack of Evidence Regarding Markers Identifying Acute Heart Failure in Patients with COPD: An AI-Supported Systematic Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Sanne HB van Dijk, Marjolein GJ Brusse-Keizer, Charlotte C Bucsán, Eline H Ploumen, Wendy JC van Beurden, Job van der Palen, Carine JM Doggen, Anke Lenferink
Background: Due to shared symptoms, acute heart failure (AHF) is difficult to differentiate from an acute exacerbation of COPD (AECOPD). This systematic review aimed to identify markers that can diagnose AHF underlying acute dyspnea in patients with COPD presenting at the hospital. Methods: All types of observational studies and clinical trials that investigated any marker’s ability to diagnose AHF
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Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Si Mong Yoon, Kwang Nam Jin, Hyo Jin Lee, Hyun Woo Lee, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Jung-Kyu Lee
Background: Preserved ratio impaired spirometry (PRISm) is a heterogeneous disease entity. Limited data are available regarding its prevalence, clinical course, or prognosis. We aimed to evaluate the longitudinal clinical course of patients with PRISm compared with chronic obstructive pulmonary disease (COPD). Methods: A retrospective study enrolled PRISm and COPD patients who underwent chest computed
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Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang
Purpose: The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Patients and Methods: Six hundred and nineteen patients
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GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-22 Honge Li, Raorao Wang, Xueyan Wei, Chunyan Zhang, Wenhui Pei, Xuhui Zhang, Zhen Yang, Zhi Li, Yuhuan Zhang, Yanli Shi, Yunchao Wang, Xinhua Wang
Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in
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TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Luca Richeldi, Pietro Schino, Elena Bargagli, Alberto Ricci, Alberto Rocca, Francesca Marchesani, Alfio Pennisi, Gianna Camiciottoli, Maria D'Amato, Francesco Macagno, Ulrica Scaffidi Argentina, Eleonora Ingrassia, Alessio Piraino
Purpose: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient’s experience and perspective through the use of patients reported outcomes. Patients and Methods: TRITRIAL was a multicenter, prospective, observational
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Relationship Between Systemic Immune-Inflammation Index and Risk of Respiratory Failure and Death in COPD: A Retrospective Cohort Study Based on the MIMIC-IV Database Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-19 Ye Zhang, Xiaoli Tan, Shiyu Hu, Zhifang Cui, Wenyu Chen
Purpose: Chronic obstructive pulmonary disease (COPD) concurrent with respiratory failure (RF) is devastating, and may result in death and disability. Systemic immune-inflammation index (SII) is a new prognostic biomarker linked to unfavorable outcomes of acute coronary syndrome, ischemic stroke, and heart failure. Nonetheless, its role in COPD is rarely investigated. Consequently, this study intends
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Case-Finding and Treatment Effects in COPD: Secondary Analysis of an Interdisciplinary Intervention Trial Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-14 Kate Petrie, Michael J Abramson, Johnson George
Background: US Preventive Services Taskforce recommends against screening for COPD in asymptomatic adults due to limited evidence on the efficacy of treatments for this population. However, global and Australian guidelines recommend a case-finding approach where those with symptoms and/or risk factors, including smoking, are screened. This study aims to explore patient characteristics by time of COPD
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Inpatient Admissions and Re-Admissions in Medicare Beneficiaries Initiating Umeclidinium/Vilanterol or Tiotropium Therapy Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-13 Michael Bogart, Gary Yat-Hung Leung, Anissa Cyhaniuk, Kristi DiRocco
Purpose: Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized are more likely to die from their illness and have increased likelihood of re-admission than those who are not. Subsequent re-admissions further increase the burden on healthcare systems. This study compared inpatient admission rates and time-to-first COPD-related inpatient admission among Medicare beneficiaries
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Glucocorticoid Use in Patients Hospitalized with Chronic Obstructive Pulmonary Disease Exacerbations Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-12 Songsong Yu, Shuang Li, Jie Zhang, Qiuhong Fang
Objective of the Study: Systemic glucocorticoid therapy can improve the outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The study tried to investigate the use of glucocorticoids in AECOPD patients and the factors associated with the physicians’ choice. Methodology: Patients with AECOPD over two periods were divided by the year of 2017 when GOLD and ERS/ATS Guideline
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Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-08 Wenjie Huang, Ting Luo, Mengqiu Lan, Wenting Zhou, Ming Zhang, Lihong Wu, Zhenni Lu, Li Fan
Purpose: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, characterized by intense lung infiltrations of immune cells (macrophages and monocytes). While existing studies have highlighted the crucial role of the competitive endogenous RNA (ceRNA) regulatory network in COPD development, the complexity and characteristics of the ceRNA network in monocytes remain
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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-07 Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia
Purpose: Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is a sudden worsening of symptoms in patients with Chronic Obstructive Pulmonary Disease (COPD), such as cough, increased sputum volume, and sputum purulence. COPD and AECOPD are characterized by damage to cilia and increased mucus secretion. Mucociliary clearance (MCC) functions as part of the primary innate system of the
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Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-05 Haules Robbins Zaniku, Emilia Connolly, Moses Banda Aron, Beatrice Lydia Matanje, Myness Kasanda Ndambo, George Complex Talama, Fabien Munyaneza, Todd Ruderman, Jamie Rylance, Luckson Wandani Dullie, Rejani Lalitha, Ndaziona Peter Kwanjo Banda, Adamson S Muula
Introduction: Chronic obstructive pulmonary disease (COPD) continues to pose a global public health challenge. However, literature is scarce on the burden of COPD in Malawi. We assessed the prevalence and risk factors for COPD among adults in Neno, Malawi. Methodology: We conducted a population-based analytical cross-sectional study in Neno District between December 2021 and November 2022. Using a
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Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease Among Users of Primary Health Care Facilities in Morocco Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-05 Nadia Al wachami, Maryem Arraji, Younes Iderdar, Yassmine Mourajid, Karima Boumendil, Fatima Zahra Bouchachi, Samira Jaouhar, Morad Guennouni, Fatimazahra Laamiri, Noureddine Elkhoudri, Lahcen Bandadi, Mohamed Lahbib Louerdi, Abderraouf Hilali, Mohamed Chahboune
Background: Chronic obstructive pulmonary disease (COPD) is a major public health problem. In Morocco, few studies have focused on COPD in primary health care facilities, whose main mission is prevention. The aim of our work is thus to assess the prevalence of COPD and to study the factors associated with this silent disease among users of health care facilities in Morocco. Methods: This is a cross-sectional
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Circular RNA_0025843 Alleviated Cigarette Smoke Extract Induced Bronchoalveolar Epithelial Cells Ferroptosis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-03 Jia Chen, Xiaoyu Deng, Hansheng Xie, Caiyun Wang, Jiefeng Huang, Ningfang Lian
Purpose: Circular RNA (circRNA) plays an important role in various biological processes. However, their functions in cigarette smoke extract (CSE) induced human normal lung epithelial cells (BEAS-2B) injury remain vague. The study aimed to explore circRNA expression profiles and reveal their potential roles in CSE-treated BEAS-2B cells. Methods: 5% CSE exposure for 24 hours were used to build the BEAS-2B
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Alpha-1 Antitrypsin Gene Variants in Patients without Severe Deficiency Diagnosed with Pulmonary Emphysema on Chest CT Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-03 Eduardo Laviña, Sara Lumbreras, Lara Bravo, Joan B Soriano, José Luis Izquierdo, Jose Miguel Rodríguez
Introduction: Although pulmonary involvement due to alpha-1 antitrypsin (AAT) deficiency has been widely described, most studies focus on the genotypes causing severe deficiency (< 60 mg/dL). Objective: The aim of this study was to analyze the prevalence of the different AAT gene variants that do not cause severe deficiency in patients with pulmonary emphysema diagnosed by thoracic computed tomography
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Association of Chronic Obstructive Pulmonary Disease with Risk of Psychiatric Disorders: A Two-Sample Mendelian Randomization Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-01 Qinxia Zhang, Haifu Zhang, Qinxing Xu
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder often accompanied by comorbidities. Although the past few years have witnessed significant scientific progress, the potential relationship between COPD and mental illness remains a subject of debate. Materials and Methods: We retrieved COPD data from the genome-wide association studies (GWAS) directory and
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Addressing Barriers to Chronic Obstructive Pulmonary Disease (COPD) Care: Three Innovative Evidence-Based Approaches: A Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-01 Damian Chi Hong Siu, Liat Gafni-Lachter
Abstract: Chronic obstructive pulmonary disease (COPD) is a preventable yet widespread and profoundly debilitating respiratory condition, exerting substantial personal and global health ramifications alongside significant economic implications. The first objective of this literature review was to identify reviews the barriers to optimal COPD care, categorizing them into personal patient factors, professional
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Lung Ultrasound Assessment of Lung Hyperinflation in Patients with Stable COPD: An Effective Diagnostic Tool Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-27 Yongjian Chen, Jingyun Li, Zhixing Zhu, Guorong Lyu
Purpose: To evaluate the degree of lung hyperinflation (LH) in patients with stable chronic obstructive pulmonary disease (COPD) by lung ultrasound score (LUS) and assess its value. Patients and Methods: We conducted a study of 149 patients with stable COPD and 100 healthy controls recruited by the Second Affiliated Hospital of Fujian Medical University. The pleural sliding displacement (PSD) was measured
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ApoA1, ApoB, ApoA1/B for Pathogenic Prediction of Chronic Obstructive Pulmonary Disease Complicated by Acute Lower Respiratory Tract Infection: A Cross-Sectional Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-26 Jiaqi Meng, Weichang Yang, Ziyong Chen, Caixia Pei, Xinmin Peng, Can Li, Fengyuan Li
Purpose: To investigate the value of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ApoA1/B ratio in pathogenic diagnosis of chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infection, assisting comprehensive disease assessment. Patients and Methods: The study enrolled 171 COPD patients with acute lower respiratory tract infections, 35 COPD patients
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Exploring a Potential Causal Link Between Dietary Intake and Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-26 Chenwei Zhang, Lu Yu, Tao Xiong, Yukai Zhang, Juan Liu, Jingfen Zhang, Peiyun He, Yujia Xi, Yi Jiang
Background: Chronic Obstructive Pulmonary Disease (COPD), the most prevalent chronic respiratory condition, significantly impairs patients’ quality of life. The pivotal element in disease management lies in prevention, underscoring the paramount importance of employing a scientific approach to investigate early prevention strategies for COPD. Methods: This study delved into the causal link between
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Real-World Disease Burden and Healthcare Resource Utilization Among Patients with COPD and Asthma Using Triple Therapy (FF/UMEC/VI) in the United States Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-25 Emmeline Igboekwe, Sumit Verma, Rosirene Paczkowski
Purpose: Chronic obstructive pulmonary disease (COPD) and asthma are associated with chronic inflammation of the respiratory tract; despite some overlap of symptoms, they are considered separate disorders. Triple therapy is recommended for patients with COPD and asthma whose symptoms remain uncontrolled despite dual therapy. There are limited real-world studies evaluating outcomes among patients with
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MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-23 Lingling Dong, Yong Wang, Haipin Chen, Zhouyang Li, Xuchen Xu, Jiesen Zhou, Huahao Shen, Zhihua Chen
Background: Macrophage-derived matrix metalloproteinase 12 (MMP12) can cause destruction of lung tissue structure and plays a significant role in the development and progression of chronic obstructive pulmonary disease (COPD). MTOR is a serine/threonine kinase that plays a crucial role in cell growth and metabolism. The activity of MTOR in the lung tissues of COPD patients also shows significant changes
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Analysis of the Current State of COPD Nursing Based on a Bibliometric Approach from the Web of Science Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-22 Zheng Tian, Yachen Jiang, Nan Zhang, Zhijun Zhang, Lan Wang
Background and Aim: COPD nursing plays a crucial role in alleviating disease symptoms, prolonging patient survival, and is therefore of paramount importance. However, authoritative research findings, research hotspots, and development trends in the field of COPD are still unclear. This study aimed to examine authoritative research findings, research hotspots, and trends in the field of COPD nursing
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Cardiovascular Events According to Inhaler Therapy and Comorbidities in Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-19 Eun Kyung Kim, Eunyoung Lee, Ji Eun Park, Jae Seung Lee, Hye Sook Choi, Bumhee Park, Seung Soo Sheen, Kwang Joo Park, Chin Kook Rhee, Sang Yeub Lee, Kwang Ha Yoo, Joo Hun Park
Background: COPD coexists with many concurrent comorbidities. Cardiovascular complications are deemed to be major causes of death in COPD. Although inhaler therapy is the main therapeutic intervention in COPD, cardiovascular events accompanying inhaler therapy require further investigation. Therefore, this study aimed to investigate new development of cardiovascular events according to each inhaler
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Risk of Death and Cardiovascular Events Following an Exacerbation of COPD: The EXACOS-CV US Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-18 Kimberly Daniels, Stephan Lanes, Arlene Tave, Michael F Pollack, David M Mannino, Gerard Criner, Amanda Neikirk, Kirsty Rhodes, Norbert Feigler, Clementine Nordon
Purpose: This study estimated the magnitude and duration of risk of cardiovascular events and mortality following acute exacerbations of chronic obstructive pulmonary disease (AECOPD), and whether risks varied by number and severity of exacerbation in a commercially insured population in the United States. Methods: This was a retrospective cohort study of newly diagnosed COPD patients ≥ 40 years old
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Biological Anti-IL-5/IL-5R Therapeutics for Chronic Obstructive Pulmonary Disease (COPD) with Specific Treatable Traits: A Real-World Retrospective Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Forest Day de Larrañaga, Alexandre Joubert, Isabelle Drouin, Isabelle Ouellet, Pei Zhi Li, Bryan A Ross, Carolyn J Baglole, Jean Bourbeau
Introduction: We describe the use of anti-IL-5 monoclonal antibodies from a COPD clinic, a source other than traditional clinical trials. The objectives were to characterize the patient subgroup prescribed anti-IL-5 monoclonal antibodies and to report potential benefits. Methods: This is a retrospective case series study of 17 patients treated in a COPD subspecialty clinic. All patients had a diagnosis
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Real-World Effectiveness of Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Kai-Michael Beeh, Karl Scheithe, Heike Schmutzler, Saskia Krüger
Purpose: Real-life effectiveness data on once-daily single-inhaler triple therapy (odSITT) with the inhaled corticosteroid fluticasone furoate (FF), the long-acting muscarinic antagonist umeclidinium (UMEC), and the long-acting β2-agonist vilanterol (VI) in patients with chronic obstructive pulmonary disease (COPD) are important to complement evidence from well-controlled randomized clinical trials
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Validation of the Rome Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbation: A Multicenter Cohort Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Jiaxin Zeng, Chen Zhou, Qun Yi, Yuanming Luo, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Xianhua Li, Pinhua Pan, Mengqiu Yi, Lina Cheng, Liang Liu, Jiarui Zhang, Lige Peng, Jiaqi Pu, Haixia Zhou
Background: The Rome severity classification is an objective assessment tool for the severity of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) based on readily measurable variables but has not been widely validated. The aim of this study is to evaluate the validity of the Rome classification in distinguishing the severity of AECOPD based on short-term mortality and other adverse
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Shifting Responsibilities: Developing a Pan-European Service Model for an eHealth Technology Supporting Self-Management of People with Chronic Obstructive Pulmonary Disease and Comorbidities Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Eline te Braake, Christiane Grünloh, Monique Tabak
Introduction: Active participation of patients in their care via self-management is an important pillar to manage chronic conditions. Self-management education and continuous support are needed to improve patients’ confidence to take such active role. One way to do this is through eHealth technologies. However, those technologies can only be successful when actively used in daily practice and when
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COPD in Never-Smokers: BOLD Australia Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Marsha A Ivey, Sheree M Smith, Geza Benke, Brett G Toelle, Michael L Hunter, Alan L James, Graeme P Maguire, Richard Wood-Baker, David P Johns, Guy B Marks, Michael J Abramson
Purpose: Tobacco smoking is the major risk factor for COPD, and it is common for other risk factors in never-smokers to be overlooked. We examined the prevalence of COPD among never-smokers in Australia and identified associated risk factors. Methods: We used data from the Australia Burden of Obstructive Lung Disease (BOLD) study, a cross-section of people aged ≥ 40 years from six sites. Participants
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Prevalence of Cardiovascular Disease and Rate of Major Adverse Cardiovascular Events in Severe Alpha-1 Antitrypsin Deficiency COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-17 Paul Ellis, Emily Bailey, Radmila Choate, Kristen E Holm, Robert A Sandhaus, Alice M Turner, Michael Newnham
Aim: Alpha-1 antitrypsin deficiency is an autosomal co-dominant condition that predisposes individuals to early-onset emphysema. As with COPD, AATD-COPD is associated with pulmonary exacerbations, which impacts on overall mortality and quality of life. Though there is evidence that COPD is associated with a higher prevalence of cardiovascular disease and major adverse cardiovascular events (MACE),
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A Low Eosinophil to Platelet Ratio as a Worse Prognostic Index for Emergency Department Attendance in Acute Exacerbation of COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-16 Dapeng Hu, Junwen Huang, Wenqu Zhao, Maosheng Xu, Yanyan Ma, Zhaoqian Gong, Qian Zhang, Haijin Zhao
Purpose: Identifying prognosis for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is challenging. Eosinophils and platelet are involved in the development of COPD, which may predict adverse events. The objective of this study was to determine the effect of the eosinophil to platelet ratio (EPR) in predicting adverse events in patients with AECOPD who visited the
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Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Are There Significant Differences Between Hospitalized and Emergency Department Patients? Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-16 Mathieu D Saint-Pierre
Rationale: Current guidelines define a severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as an increase in symptoms requiring hospital admission or emergency department (ED) visit. Little is known about whether or not subjects requiring hospitalization and those needing only ED care have similar patient profiles and if their clinical outcomes appear comparable. Objective:
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Physicians’ Knowledge of Pulmonary Rehabilitation in China: A Cross-Sectional Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-16 Feng Pan, Ai-ting Lu, Xiaowei Mao, Fang Hu, Hai Zhang, Baohui Han
Objective: To investigate the knowledge of pulmonary rehabilitation (PR) among physicians involved in pulmonary disease management. Methods: This multi-regional cross-sectional survey was conducted from December 12, 2019 to January 22, 2020. The participants were enrolled and an electronic questionnaire was exclusively sent to the members of the Lung Cancer Special Committee of the China Medicine Education
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Obesity Prevalence and Association with Spirometry Profiles, ICU Admission, and Comorbidities Among Patients with COPD: Retrospective Study in Two Tertiary Centres in Saudi Arabia Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-16 Abdullah A Alqarni, Omaima I Badr, Abdulelah M Aldhahir, Jaber S Alqahtani, Rayan A Siraj, Abdallah Y Naser, Abdulrhman S Alghamdi, Mansour Majrshi, Saeed M Alghamdi, Mohammed M Alyami, Sara A Alghamdi, Hassan Alwafi
Background: Obesity is common among chronic obstructive pulmonary disease (COPD) patients and is associated with an increase in acute exacerbation episodes. However, data on obesity’s impact on and association with clinical outcomes among patients with COPD are limited. This study aimed to determine overweight and obesity prevalence and associations with spirometry profiles, intensive care unit (ICU)
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Outcomes Following Initiation of Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol versus Multiple-Inhaler Triple Therapy Among Medicare Advantage with Part D Beneficiaries and Those Commercially Enrolled for Health Care Insurance in the United States Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-11 Michael Bogart, Lindsay GS Bengtson, Mary G Johnson, Scott H Bunner, Noelle N Gronroos, Kristi K DiRocco
Purpose: Patients with chronic obstructive pulmonary disease (COPD) have been shown to benefit from triple therapy commonly delivered by multiple-inhaler triple therapy (MITT); however, the complexity of MITT regimens may decrease patient adherence. Fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI), a once-daily single-inhaler triple therapy (SITT), became available in the United States (US)
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The Causal Relationship Between Gastroesophageal Reflux Disease and Chronic Obstructive Pulmonary Disease: A Bidirectional Two-Sample Mendelian Randomization Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-10 Bo Liu, Mengling Chen, Junjie You, Silin Zheng, Min Huang
Background: Gastroesophageal reflux disease (GERD) and Chronic Obstructive Pulmonary Disease (COPD) often coexist and have been associated in observational studies. However, the real potential causal relationship between GERD and COPD is unknown and not well established. Methods: In this study, we conducted a bidirectional two-sample Mendelian randomization(MR) to estimate whether GERD and COPD are
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Real-World Effectiveness Study of Nirmatrelvir-Ritonavir or Molnupiravir in Hospitalized Unvaccinated Patients with Chronic Respiratory Diseases and Moderate COVID-19 at Presentation Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-09 Wang Chun Kwok, Terence Chi Chun Tam, James Chung Man Ho, David Chi Leung Lam, Mary Sau-Man Ip, Pak Leung Ho
Introduction: Nirmatrelvir-ritonavir (NMV-r) and molnupiravir (MOL) were developed as out-patient anti-viral for mild COVID-19. There was limited data on their role in treating COVID-19 for hospitalized patients, especially among adult patients who are unvaccinated and had chronic respiratory diseases. Methods: A territory-wide retrospective study was conducted in Hong Kong to compare the efficacy
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Correlation Between Diaphragmatic Excursion and Exercise Tolerance Improvement Following Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease-Obstructive Sleep Apnea Overlap Syndrome Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-09 Honghua Shen, Yiming Xu, Yin Zhang, Lei Ren, Rui Chen
Purpose: We assess the predictive value of diaphragm excursion (DE) in enhancing exercise tolerance following pulmonary rehabilitation (PR) among patients with COPD-OSA overlap syndrome. Material and Methods: This prospective cohort study enrolled 63 patients diagnosed with COPD-OSA overlap syndrome who actively participated in a PR program from January 2021 to May 2023. Among these, 58 patients successfully
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Quantitative Assessment Characteristics of Small Pulmonary Vessel Remodelling in Populations at High Risk for COPD and Smokers Using Low-Dose CT Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-06 Yu Pu, Xiuxiu Zhou, Di Zhang, Yu Guan, Yi Xia, Shiyuan Liu, Li Fan
Purpose: To explore the morphological alterations in small pulmonary vessels in populations at high risk for chronic obstructive pulmonary disease (COPD) and smokers based on multiple computed tomography (CT) quantitative parameters. Patients and Methods: A total of 1969 Three Major Chest Diseases Screening Study participants with available demographic data and smoking history who underwent low-dose