Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-13
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua
Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI)
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-09
Eric C. Anderson, John DiPalazzo, F. Lee Lucas, Michael J. Hall, Andrey Antov, Petra Helbig, Jennifer Bourne, Leah Graham, Lory Gaitor, Christine Lu-Emerson, Leslie S. Bradford, Roger Inhorn, Sarah J. Sinclair, Philip L. Brooks, Christian A. Thomas, Karen Rasmussen, Paul K. J. Han, Edison T. Liu, Jens Rueter
Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-11
V. J. Forster, M. Aronson, C. Zhang, J. Chung, S. Sudhaman, M. A. Galati, J. Kelly, L. Negm, A. B. Ercan, L. Stengs, C. Durno, M. Edwards, M. Komosa, L. E. Oldfield, N. M. Nunes, S. Pedersen, J. Wellum, I. Siddiqui, V. Bianchi, B. R. Weil, V. L. Fox, T. J. Pugh, J. Kamihara, U. Tabori
Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-07
Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Remodeling the tumor-immune microenvironment by anti-CTLA4 blockade enhanced subsequent anti-PD-1 efficacy in advanced nasopharyngeal carcinoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-06
Yuxiang Ma, Huaqiang Zhou, Fan Luo, Yang Zhang, Changbin Zhu, Weiwei Li, Zhan Huang, Jingbo Zhao, Jinhui Xue, Yuanyuan Zhao, Wenfeng Fang, Yunpeng Yang, Yan Huang, Li Zhang, Hongyun Zhao
Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-04
Vivek Subbiah, Mohamed A. Gouda, J. Bryan Iorgulescu, Ramona Dadu, Keyur Patel, Steven Sherman, Maria Cabanillas, Mimi Hu, Luz E. Castellanos, Behrang Amini, Funda Meric-Bernstam, Tao Shen, Jie Wu
New pan-ALK inhibitor-resistant EML4::ALK mutations detected by liquid biopsy in lung cancer patients
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-06
Matteo Villa, Federica Malighetti, Elisa Sala, Geeta G. Sharma, Giulia Arosio, Maria Gemelli, Chiara Manfroni, Diletta Fontana, Nicoletta Cordani, Raffaella Meneveri, Alfonso Zambon, Rocco Piazza, Fabio Pagni, Diego Cortinovis, Luca Mologni
An interpretable machine learning system for colorectal cancer diagnosis from pathology slides
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-05
Pedro C. Neto, Diana Montezuma, Sara P. Oliveira, Domingos Oliveira, João Fraga, Ana Monteiro, João Monteiro, Liliana Ribeiro, Sofia Gonçalves, Stefan Reinhard, Inti Zlobec, Isabel M. Pinto, Jaime S. Cardoso
Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-02
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du
Patient derived tumoroids of high grade neuroendocrine neoplasms for more personalized therapies
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-01
Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-03-01
Youpeng Wang, Ziyin Zhao, Tingting Guo, Tiansong Wu, Mao Zhang, Dingan Luo, Kunpeng Dou, Yeni Yang, Cheng Jin, Bingyuan Zhang, Bin Zhang, Bing Han
Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-29
Jiahao Zhang, Yiheng Huang, Yichao Han, Dong Dong, Yuqin Cao, Xiang Chen, Di Liu, Xueyan Cheng, Debin Sun, Hecheng Li, Yajie Zhang
Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-27
Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-26
Yanwei Zhang, Beibei Sun, Yinghong Yu, Jun Lu, Yuqing Lou, Fangfei Qian, Tianxiang Chen, Li Zhang, Jiancheng Yang, Hua Zhong, Ligang Wu, Baohui Han
A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-27
Dexter Kai Hao Thng, Lissa Hooi, Bei En Siew, Kai-Yin Lee, Ian Jse-Wei Tan, Bettina Lieske, Norman Sihan Lin, Alfred Wei Chieh Kow, Shi Wang, Masturah Bte Mohd Abdul Rashid, Chermaine Ang, Jasmin Jia Min Koh, Tan Boon Toh, Ker-Kan Tan, Edward Kai-Hua Chow
Genomic landscape of liquid biopsy mutations in TP53 and DNA damage genes in cancer patients
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-26
Damien Vasseur, Ahmadreza Arbab, Fabiola Giudici, Christophe Marzac, Stefan Michiels, Marco Tagliamento, Arnaud Bayle, Cristina Smolenschi, Madona Sakkal, Mihaela Aldea, Hela Sassi, Filippo Gustavo Dall’Olio, Noémie Pata-Merci, Sophie Cotteret, Alice Fiévet, Nathalie Auger, Luc Friboulet, Francesco Facchinetti, Arthur Géraud, Santiago Ponce, Antoine Hollebecque, Benjamin Besse, Jean Baptiste Micol
UroPredict: Machine learning model on real-world data for prediction of kidney cancer recurrence (UroCCR-120)
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-23
Gaëlle Margue, Loïc Ferrer, Guillaume Etchepare, Pierre Bigot, Karim Bensalah, Arnaud Mejean, Morgan Roupret, Nicolas Doumerc, Alexandre Ingels, Romain Boissier, Géraldine Pignot, Bastien Parier, Philippe Paparel, Thibaut Waeckel, Thierry Colin, Jean-Christophe Bernhard
A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-23
Mai Suzuki, Ken Uchibori, Tomoko Oh-hara, Yumi Nomura, Ryusei Suzuki, Ai Takemoto, Mitsugu Araki, Shigeyuki Matsumoto, Yukari Sagae, Mutsuko Kukimoto-Niino, Yusuke Kawase, Mikako Shirouzu, Yasushi Okuno, Makoto Nishio, Naoya Fujita, Ryohei Katayama
Sequencing of cerebrospinal fluid cell-free DNA facilitated early differential diagnosis of intramedullary spinal cord tumors
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-22
Ruichao Chai, Songyuan An, Han Lin, Bo Pang, Hao Yan, Yun Liu, Yilin Wu, Long Wang, Xing Liu, Huiyuan Chen, Xueyu Yang, Qing Chang, Wenqing Jia, Yongzhi Wang
A whirl of radiomics-based biomarkers in cancer immunotherapy, why is large scale validation still lacking?
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-21
Marta Ligero, Bente Gielen, Victor Navarro, Pablo Cresta Morgado, Olivia Prior, Rodrigo Dienstmann, Paolo Nuciforo, Stefano Trebeschi, Regina Beets-Tan, Evis Sala, Elena Garralda, Raquel Perez-Lopez
Machine learning and radiomics for segmentation and classification of adnexal masses on ultrasound
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-20
Jennifer F. Barcroft, Kristofer Linton-Reid, Chiara Landolfo, Maya Al-Memar, Nina Parker, Chris Kyriacou, Maria Munaretto, Martina Fantauzzi, Nina Cooper, Joseph Yazbek, Nishat Bharwani, Sa Ra Lee, Ju Hee Kim, Dirk Timmerman, Joram Posma, Luca Savelli, Srdjan Saso, Eric O. Aboagye, Tom Bourne
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-19
Nona Struyf, Albin Österroos, Mattias Vesterlund, Cornelia Arnroth, Tojo James, Stephanie Sunandar, Georgios Mermelekas, Anna Bohlin, Kerstin Hamberg Levedahl, Sofia Bengtzén, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi, Brinton Seashore-Ludlow, Tom Erkers
EORTC-SPECTA Arcagen study, comprehensive genomic profiling and treatment adaptation of rare thoracic cancers
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-16
Marco Tagliamento, Marie Morfouace, Charalambos Loizides, Julio Oliveira, Laurent Greillier, Judith Raimbourg, Anne-Claire Toffart, Thierry Chatellier, Nicolas Cloarec, Ivana Sullivan, Birute Brasiuniene, Michael Duruisseaux, Kersti Oselin, Marie-Sophie Robert, Carolina Fernandes, Arnaud Poncin, Jean-Yves Blay, Benjamin Besse, Nicolas Girard
Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-15
Stephanie N. Shishido, Emmeline Lin, Nicholas Nissen, George Courcoubetis, Divya Suresh, Jeremy Mason, Arsen Osipov, Andrew E. Hendifar, Michael Lewis, Srinivas Gaddam, Stephen Pandol, Peter Kuhn, Simon K. Lo
Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-14
Charlotte S. Walmsley, Philip Jonsson, Michael L. Cheng, Sean McBride, Christopher Kaeser, Herbert Alberto Vargas, Vincent Laudone, Barry S. Taylor, Rajya Kappagantula, Priscilla Baez, Allison L. Richards, Anne Marie Noronha, Dilmi Perera, Michael Berger, David B. Solit, Christine A. Iacobuzio-Donahue, Howard I. Scher, Mark T. A. Donoghue, Wassim Abida, Alison M. Schram
Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-12
Higinio Dopeso, Andrea M. Gazzo, Fatemeh Derakhshan, David N. Brown, Pier Selenica, Sahar Jalali, Arnaud Da Cruz Paula, Antonio Marra, Edaise M. da Silva, Thais Basili, Laxmi Gusain, Lorraine Colon-Cartagena, Shirin Issa Bhaloo, Hunter Green, Chad Vanderbilt, Steffi Oesterreich, Anne Grabenstetter, M. Gabriela Kuba, Dara Ross, Dilip Giri, Hannah Y. Wen, Hong Zhang, Edi Brogi, Britta Weigelt, Fresia
Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-06
Xiaohan Shen, Jiao Dai, Lingchuan Guo, Zhigang Liu, Liu Yang, Dongmei Gu, Yinghong Xie, Zhuo Wang, Ziming Li, Haimiao Xu, Qihui Shi
Deep representation learning of tissue metabolome and computed tomography annotates NSCLC classification and prognosis
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-03
Marc Boubnovski Martell, Kristofer Linton-Reid, Sumeet Hindocha, Mitchell Chen, Paula Moreno, Marina Álvarez‐Benito, Ángel Salvatierra, Richard Lee, Joram M. Posma, Marco A. Calzado, Eric O. Aboagye
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-03
Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Paul Edelkamp, Kristin Alfaro-Munoz, Ray Chacko, Jennifer Peterson, Brandon G. Smaglo, Robert A. Wolff, Shubham Pant, Michael S. Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark W. Hurd, Rebecca Snyder, Matthew H. G. Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao
Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-02-01
Chiara Chiavelli, Malvina Prapa, Giulia Rovesti, Marco Silingardi, Giovanni Neri, Giuseppe Pugliese, Lucia Trudu, Massimiliano Dall’Ora, Giulia Golinelli, Giulia Grisendi, Jonathan Vinet, Marco Bestagno, Carlotta Spano, Roberto Vito Papapietro, Roberta Depenni, Katia Di Emidio, Anna Pasetto, Daniela Nascimento Silva, Alberto Feletti, Silvia Berlucchi, Corrado Iaccarino, Giacomo Pavesi, Massimo Dominici
Multi-omics analysis reveals NNMT as a master metabolic regulator of metastasis in esophageal squamous cell carcinoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-01-30
Qi Huang, Haiming Chen, Dandan Yin, Jie Wang, Shaodong Wang, Feng Yang, Jiawei Li, Teng Mu, Jilun Li, Jia Zhao, Rong Yin, Wei Li, Mantang Qiu, Erbao Zhang, Xiangnan Li
A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-01-26
Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Youjun Chu, Beibei Fu, Xiaoliang Jin, Jan-Philipp Mallm, Moritz Mall, Yonghe Wu, Almut Schulze, Hai-Kun Liu
Viable tumor cell density after neoadjuvant chemotherapy assessed using deep learning model reflects the prognosis of osteosarcoma
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-01-22
Kengo Kawaguchi, Kazuki Miyama, Makoto Endo, Ryoma Bise, Kenichi Kohashi, Takeshi Hirose, Akira Nabeshima, Toshifumi Fujiwara, Yoshihiro Matsumoto, Yoshinao Oda, Yasuharu Nakashima
A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-01-16
Qiong Wang, Bisheng Cheng, Sandeep Singh, Yiran Tao, Zhongqiu Xie, Fujun Qin, Xinrui Shi, Jingjing Xu, Chenxi Hu, Wanlong Tan, Hui Li, Hai Huang
Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer
npj Precis. Oncol.
(IF 7.9 )
Pub Date : 2024-01-10
Yan Qin Tan, Yi-Shiou Chiou, Hui Guo, Shuwei Zhang, Xiaoming Huang, Dukanya Dukanya, Arun M. Kumar, Shreeja Basappa, Suling Liu, Tao Zhu, Basappa Basappa, Vijay Pandey, Peter E. Lobie
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