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Fertility-Sparing Surgery in Infiltrative Mucinous Carcinoma of the Ovary. Case Rep. Oncol. Pub Date : 2023-11-29 Sarra Ben Ltaief,Montassar Ghalleb,Azza Chabchoub,Maher Slimen,Linda Hadj Kacem,Yosr Zenzeri,Riadh Chargui,Tarek Dhieb
Introduction Mucinous ovarian carcinoma is often diagnosed early and can affect young patients. The preservation of the female reproductive organ is one of the critical issues, especially for nulliparous women. This case report aims to reconsider the safe outcome of fertility-sparing surgery for infiltrative type mucinous ovarian carcinoma. Case Presentation A 28-year-old woman with a right mucinous
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Metastatic Salivary Duct Carcinoma with ERBB2 Amplification and Sequential Response to Ado-Trastuzumab Emtansine and Neratinib: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-29 Nora Asper,Kersten Sven Roth,Thomas Frank Hany,Sacha Pierre Salzberg,Marianne Tinguely,Yannick Kadvany,Andreas Trojan
Introduction Salivary duct carcinoma (SDC) is an aggressive and rare subtype of salivary gland carcinoma. Surgical excision and radiotherapy are standard of care for early cancer. Chemotherapies with taxanes and platinum show overall response rates between 39% and 50%. SDCs are often associated with an overexpression of the androgen receptor (AR) and HER2/neu which have recently become druggable targets
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Metastatic Seminoma Presenting in Kidney and Cervical Lymph Nodes after a 25-Year Interval: A Case Report and Literature Review. Case Rep. Oncol. Pub Date : 2023-11-29 Azar Naimi,Somayeh Hajiahmadi,Haniyeh Sohrabi
Introduction Seminoma comprises approximately 50% of testicular germ cell tumors. Retroperitoneal lymph nodes are the most common initial metastatic sites but renal metastases are infrequent and the majority of renal tumors represent primary neoplasm. Case Presentation In this study, we present a 48-year-old male with metastases of seminoma to the cervical lymph nodes and kidney after a 25-year interval
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Recurrent, Tumor Mutation Burden-High, Cutaneous Angiosarcoma of the Scalp Treated with Pembrolizumab. Case Rep. Oncol. Pub Date : 2023-11-28 Ryo Amagai,Taku Fujimura,Yumi Kambayashi,Kentaro Ohuchi,Emi Yamazaki,Akira Hashimoto,Yoshihide Asano
Introduction Chemoradiotherapy with taxanes is well-recognized as a first-line therapy for cutaneous angiosarcoma (CAS), but second-line therapy for CAS is still controversial. Case Presentation In this report, we described a 75-year-old Japanese case of recurrent, tumor mutation burden-high CAS on the scalp treated with pembrolizumab. Our present case survived for 1 year despite of taxane refractory
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A Case of Cystic Retroperitoneal Dedifferentiated Liposarcoma Diagnosed by Percutaneous Image-Guided Biopsy. Case Rep. Oncol. Pub Date : 2023-11-24 Kaede Morihara,Takahito Negishi,Nobuki Furubayashi,Hiroki Kobayashi,Mikako Jinnouchi,Kenji Shinozaki,Yutaka Koga,Kenichi Taguchi,Motonobu Nakamura
Introduction Dedifferentiated liposarcoma (DDLP) was initially defined as a tumor containing differentiated liposarcoma and distinct regions of nonlipogenic spindle cell or pleomorphic sarcoma. Retroperitoneal liposarcomas feature a characteristic appearance with a predominantly fatty component, and cystic liposarcomas are rare. We describe a case of retroperitoneal DDLP predominantly consisting of
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HER2-Positive Metaplastic Breast Cancer with Resistance to Neoadjuvant Chemotherapy: Case Report. Case Rep. Oncol. Pub Date : 2023-11-24 Kaho Tateishi,Megumi Kiyoi,Miwako Miyasaka,Mari Kawaji,Hitomi Nakanishi,Yuki Furuta,Mana Nishimatsu,Yuichi Takahashi,Mizuki Nishikawa,Yoshiharu Nishimura
Introduction Metaplastic breast carcinoma (MBC) is a rare histologic subtype of breast carcinoma, which is usually negative for estrogen receptor, progesterone receptor, and HER2. HER2-positive MBC is therefore extremely rare. Most MBCs have poor response to chemotherapy. HER2-targeted neoadjuvant chemotherapy (NAC) is widely performed and has high efficacy in treating HER2-positive breast cancer.
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Entrectinib for NTRK Fusion-Positive Metastatic Melanoma Progressing on Combined PD-1 and CTLA-4 Inhibition: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-24 Shaheenah Dawood,Zulfaqqar Jaffar Ali
Introduction The burden of melanoma is increasing globally. Despite the use of immunotherapy and targeted therapy, the prognosis of metastatic melanoma remains relatively poor. The integration of comprehensive molecular profiling can lead to the detection of actionable biomarkers and the expansion of treatment options, thereby prolonging cancer patient survival. Case Presentation We herein present
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Pterygoid Muscle Necrosis Caused by Radiation and Intra-Arterial Cisplatin Infusion Chemotherapy (RADPLAT): A Case Report. Case Rep. Oncol. Pub Date : 2023-11-24 Kazuhiro Miyamoto,Mitsuo Sato,Satoru Koike,Takayuki Kimura,Daisuke Abe,Takahiro Wakasaki,Mutsukazu Kitano,Ryuji Yasumatsu
Introduction Radiation and intra-arterial cisplatin infusion chemotherapy (RADPLAT) for advanced maxillary sinus cancer has accumulated evidence as a treatment with fewer complications and better 5-year survival rates. In this study, we report a case in which pterygoid muscle necrosis occurred 6 months following RADPLAT treatment for maxillary sinus cancer. Case Presentation The 45-year-old woman had
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Pegfilgrastim-Induced Aortitis in a Patient with Small-Cell Lung Cancer Who Received Immunotherapy Combined with Chemotherapy. Case Rep. Oncol. Pub Date : 2023-11-24 Takanori Ito,Osamu Kanai,Zentaro Saito,Takuma Imakita,Issei Oi,Kohei Fujita,Hiromasa Tachibana,Tadashi Mio
Introduction Granulocyte colony-stimulating factor (G-CSF), including pegfilgrastim, increases the peripheral blood leukocyte count and is widely used in clinical practice in combination with cytotoxic chemotherapy. The most frequent side effects of G-CSF are pain and fever; aortitis, in contrast, is a rare and serious side effect. Case Presentation A 73-year-old man with small-cell lung cancer was
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An Acute Promyelocytic Leukemia Resistant to All-Trans Retinoic Acid: A Case Report of the ZBTB16::RARa Variant and Review of the Literature. Case Rep. Oncol. Pub Date : 2023-11-23 Daan A R Castelijn,Gerrit Sijm,Bianca Venniker-Punt,Pino J Poddighe,Marielle J Wondergem
Introduction Acute promyelocytic leukemia (APL) is characterized by the PML::RARa gene fusion and treatment consists of all-trans retinoic acid (ATRA). Rarely, genetic APL variants have been described which are insensitive to ATRA treatment and are therefore associated with a worse prognosis. Rapid identification of the APL variant is essential to start the correct treatment. Case Presentation Here
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Metastatic Ductal Eccrine Adenocarcinoma with Excellent Response to Immunotherapy. Case Rep. Oncol. Pub Date : 2023-11-21 Matthew Fadhil,Alistair Lochhead,Hon Trinh,Daniel Brungs
Eccrine carcinoma, a subtype of which is ductal eccrine adenocarcinoma (DEA), is a rare cutaneous malignancy. For metastatic eccrine carcinoma, there are very limited data to guide treatment. Conventional chemotherapy is of limited benefit and there is only a small body of evidence for the use of immunotherapy in non-DEA eccrine carcinomas. We report the first case of metastatic DEA treated with a
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Esophageal Infiltration by High-Grade Serous Ovarian Carcinoma: A Very Rare Case Report. Case Rep. Oncol. Pub Date : 2023-11-21 Anna Carbó-Bagué,Laura Cerón-Nasarre,Laia Valls-Masot,Cristina Melendez-Munoz,Elisabet Bujons-Buscarons,Raquel Liñan-Planas,Maria Pilar Barretina-Ginesta
Introduction Esophageal involvement in high-grade serous ovarian carcinoma is a rare phenomenon when advanced systemic disease is detected. Dysphagia is the most common guide symptom. However, diagnosis is often delayed due to its submucosal process that is not early seen in endoscopic initial evaluation, while computerized tomography (CT) scan usually shows concentric thickening of the esophageal
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Response of Brain and Meningeal Metastases to Trastuzumab-Deruxtecan in a Patient with HER2-Low Breast Cancer: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-21 Benita Wolf,Vincent Dunet,Estelle Dubruc,Ana Dolcan,Marie Nicod Lalonde,Luis Schiappacasse,Khalil Zaman
Nervous system metastases (CNSm) are late events associated with poor outcomes in endocrine-sensitive HER2-negative breast cancer (BC) patients, especially in the presence of leptomeningeal disease (LMD). Effective treatments are extremely limited in this setting. The antibody-drug conjugate, trastuzumab-deruxtecan (T-DXd), which combines the anti-HER2 antibody trastuzumab with a topoisomerase type
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Successful Chemotherapy for Diffuse Cystic Lung Metastases during Targeted Therapy with Osimertinib in a Patient with Non-Small-Cell Lung Cancer: A Literature Review and a Rare Case Report. Case Rep. Oncol. Pub Date : 2023-11-16 Akira Matsukida,Takunori Ogawa,Tomomi Tanigaki,Yusuke Serizawa,Masashi Nishimura,Shunya Igarashi,Yoshiki Kato,Akihiko Kawana,Yoshifumi Kimizuka
Introduction Diffuse lung cysts occur owing to several diseases; however, diffuse cystic lung metastases are very rare in the case of lung cancer. We report a rare case of diffuse cystic lung metastases from lung adenocarcinoma and reviewed previously reported cases of cystic lung metastases for lung cancer and determined their characteristics. Case Presentation A 78-year-old Japanese woman with advanced
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Combined Carcinoid Carcinoma and Squamous Cell Carcinoma of the Endometrium: A Case Report and Survey of Related Literature. Case Rep. Oncol. Pub Date : 2023-11-15 Ying Han,YanJun Zhang,Lin Niu,CuiQin Sang
Introduction Histologically, endometrial neuroendocrine carcinoma is an extremely rare pathological type of endometrial cancer. In addition, this type is characterized by high invasiveness and poor clinical outcome, which was classified into carcinoid (low grade), and small-cell and large-cell neuroendocrine carcinoma (high grade). Globally, reports on endometrial carcinoid carcinoma are limited. Clinically
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Synchronous Primary Lung Cancers Containing Discrete Driver Mutations in a Never-Smoker: Case Report. Case Rep. Oncol. Pub Date : 2023-11-14 Andrew Davis,Sophia Jarrar,Christine Ciunci
Although most lung cancer patients present with one primary cancer, some present with multiple lung cancers of different clonal origin. Timely recognition of synchronous multifocal primary lung cancer (MPLC) enables distinct treatment regimens that reflect the unique genotypic makeup and location of each cancer. However, recognition of synchronous MPLCs is challenging given the prevalence of multifocal
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Endocavitary Right Ventricular Cardiac Metastasis of a Lung Adenocarcinoma Treated by Surgery: A Case Report About a Novel Multimodal Therapeutic Approach. Case Rep. Oncol. Pub Date : 2023-11-14 Serge Borne,Nicolas Benoit,Youcef Douadi,Olivier Carre,Stéphanie Thielen-Bethembos,Hortense Carette De Franssu,Gilles Touati,Anna-Laura Colta,David Patrao,Emilie Delattre,Julien Monconduit,Camille Piriou-Garoute,Bruno Chauffert,Charles Dayen
Introduction Cardiac metastasis (CM) is a rare lung cancer location. It often remains clinically silent but may cause life-threatening complications. Better survival rates thanks to the immunotherapy revolution and the improving performance of imaging lead to an increasing number of CM diagnosis. Case Presentation We report a case of a 54-year-old woman who was diagnosed with a stage IIIa non-small
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A Rare Case of Severe Hypokalemia and Hypomagnesemia due to Venetoclax and Polypharmacy Leading to Life-Threatening Cardiac Arrhythmias. Case Rep. Oncol. Pub Date : 2023-11-14 Laura Torres Cruz,Sai Priyanka Pulipaka,Neenu Anthony,James Liu,Maryam Barkhodarian,Ahmad Al Awwa,Simcha Weissman
Venetoclax is a novel agent used in hematologic malignancies. Although no long-term studies have directly implicated venetoclax, few studies show possible association with electrolyte abnormalities. Severe derangements in serum electrolyte levels can cause cardiac dysrhythmias, which can be potentially fatal. We present a case of venetoclax in association with the other medications causing life-threatening
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Nonfamilial Bilateral Synchronous Renal Cell Carcinoma with Discordant Histology with Eventual Complete Response to Dual Immunotherapy. Case Rep. Oncol. Pub Date : 2023-11-13 Ian J Robertson,Sierrah M Grigsby,John C Mattingly,Dean K Park
Bilateral synchronous renal cell carcinoma (RCC) is rare, especially in sporadic rather than familial cases. While immunotherapy has improved prognosis, RCC remains a diagnosis with significant morbidity and mortality, particularly pronounced in patients with sarcomatoid RCC (sRCC). We describe a case of a patient with bilateral, synchronous, nonfamilial RCC, with and without sarcomatoid features and
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Case Series: "Silent" Spinal Epidural Metastases in Metastatic Castrate-Resistant Prostate Cancer. Case Rep. Oncol. Pub Date : 2023-11-10 Dhanusha Sabanathan,Andrew O Parsonson,John J Park,Howard Gurney
Introduction Spinal epidural metastases (SEM) are an uncommon phenomenon and traditionally occur as a preterminal event in heavily pre-treated patients. The introduction of novel anti-androgen therapies, such as enzalutamide and abiraterone acetate, has greatly improved the survival of patients with metastatic prostate cancer but may be changing the pattern of disease. Case Presentation Four patients
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Interference of Herbal Medicine with Axitinib in Metastatic Renal Cell Cancer Treatment: A Case Study. Case Rep. Oncol. Pub Date : 2023-11-09 Friederike Himmelreich,Alexander Jetter,Michael K Kiessling,Yannick Kadvany,Andreas Trojan
Introduction The awareness and the clinical relevance of the potential interactions between standard and complementary medicine are increasing in medical oncology. Nonetheless, the research and experience of the efficacy, safety, and toxicity of herbal substances are poorly documented. Case Presentation Here, we report the case of a 68-year-old female patient who had been diagnosed with advanced renal
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Abscopal Effect after Stereotactic Body Radiotherapy with Nivolumab for Lung Metastasis of Head and Neck Cancer: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-08 Masashi Endo,Yukiko Fukuda,Kouhei Okada,Kazunari Ogawa,Michiko Nakamura,Satoru Takahashi,Masahiro Kawahara,Keiko Akahane,Yoshiaki Nagai,Hironori Yamaguchi,Hiroshi Nishino,Harushi Mori,Katsuyuki Shirai
Introduction The abscopal effect (AE) is a phenomenon, in which radiotherapy exerts an antitumour effect on distant lesions outside the primary irradiated area. Although immune checkpoint inhibitors have been widely studied for their potential to enhance the AE and improve patient outcomes, findings in cases of head and neck cancers remain limited. Case Presentation We report the case of a 72-year-old
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Mixed Diffuse and Tumoral Form of Bing-Neel Syndrome Successfully Treated with Ibrutinib. Case Rep. Oncol. Pub Date : 2023-11-08 Junid A Naveed Ahmad,Brett A Schroeder,John Paul T Yun,David M Aboulafia
Introduction Bing-Neel syndrome (BNS) is a rare and heterogenous manifestation of Waldenström macroglobulinemia (WM) involving central nervous system (CNS) infiltration by malignant lymphoplasmacytic cells. Efforts to standardize diagnostic criteria have improved in recent years, as have treatment options including the use of the Bruton tyrosine kinase inhibitor (BTKI) ibrutinib. Case Presentation
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Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile. Case Rep. Oncol. Pub Date : 2023-11-08 Gorana Gašljević,Gregor Vivod,Petra Škerl,Srdjan Novaković
Uterine adenosarcoma (AS) is a rare biphasic neoplasm composed of a malignant, usually low-grade stromal component and benign epithelial component, usually endometrioid. Pathogenesis is unknown; some cases are undoubtably associated with tamoxifen use. Endometrial clear cell carcinoma (CCC) is an aggressive subtype of endometrial cancer, accounting for less than 10% of all uterine carcinomas. The etiology
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Lung Cancer Mimicking Aspergilloma: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-07 Sheikh M Wasim Jamal,Mohamed R Aboukamar,Mohamad Khatib,Muna Al Maslamani,Abdulqadir J Nashwan
An aspergilloma is a conglomeration of Aspergillus hyphae, fibrin, mucus, and cellular debris, typically found within a pulmonary cavity or ectatic bronchus. Computerized tomography (CT) scans often depict a cavity containing a solid mass and a notable crescent sign. Though these signs are indicative of aspergilloma, the European Respiratory Society emphasizes the need for a more detailed diagnostic
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Eyelid Metastasis from Cervical Cancer: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-07 Jing Wen,Chunlian Huang,Nina Guo,Wenwen Wang,Bo Sheng
Metastatic malignant lesions of the eyelids are less than 1% of all eyelid tumors. Eyelid metastasis from the cervix, particularly the first sign of metastasis, has not been reported. A female presented to an ophthalmologist with a gradually increasing mass on the lateral edge of the lower eyelid for 2 months and was diagnosed with stage IB1 cervical cancer 3 years ago. We performed wide local excision
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Metastatic Colon Cancer - An Effective Treatment Protocol of Integrative Therapies Including Electromagnetic Field Frequencies: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-07 Karin Ried,Peter Eng,Taufiq Binjemain
Introduction Colorectal cancer is the third most common cancer worldwide, with 25% of patients being diagnosed with metastatic disease, mostly in the liver, resulting in poor survival. Standard treatment of stage-IV colorectal cancer consists of primary tumour resection followed by chemotherapy. Case Presentation Here, we report on the treatment effectiveness using integrative therapies in a 52-year-old
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A Rare Case of Lambert-Eaton Myasthenia Syndrome Associated with Non-Hodgkin's Lymphoma: A Case Report and Review of the Literature. Case Rep. Oncol. Pub Date : 2023-11-06 Mohammad Abu-Tineh,Mohammed A Alamin,Esra'a Aljaloudi,Awni Alshurafa,Beatriz Garcia-Cañibano,Ruba Y Taha,Sarah A Elkourashy
Introduction Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often small-cell lung cancer. This case report describes a rare instance of paraneoplastic LEMS in a man with non-Hodgkin
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Relapse of Lung Adenocarcinoma Manifested by Spontaneous Tumor Lysis Syndrome. Case Rep. Oncol. Pub Date : 2023-11-06 Daebin Im,Katie Alsheimer,Joyson Poulose,Violeta Zeykan,Giampaolo Talamo
Introduction Tumor lysis syndrome (TLS) is an oncologic emergency characterized by several metabolic derangements, such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. TLS is typically observed in hematologic malignancies, especially after starting the first administration of antineoplastic therapies. TLS in a solid malignancy is very unusual, and exceedingly rare when occurring
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Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review. Case Rep. Oncol. Pub Date : 2023-11-06 Duna Barakeh,Afaf Alsolami,Malak Abedalthagafi
Ameloblastic fibrosarcoma (AFS) is considered a malignant progression resulting from dysplastic changes in an ameloblastic fibroma (AF). Both tumors are extremely rare, with only a few cases reported in the scientific literature. Notably, BRAF mutations have been identified in ameloblastomas, suggesting a connection between ameloblastic morphology and BRAF mutations, as AF is believed to be the precursor
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Oral Chronic Graft-versus-Host Disease in Post-Hematopoietic Stem Cell Transplant Patients Following SARS-CoV-2 Vaccination: Case Reports. Case Rep. Oncol. Pub Date : 2023-11-03 Joel B Epstein,Raymond S Hernandez,Ryotaro Nakamura,Susan E Yost,Haris Ali
Patients receiving allogeneic hematopoietic stem cell transplant may experience graft-versus-host disease (GVHD) in which donor immune cells cause an immune reaction in host tissues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines are highly effective in prevention of severe coronavirus-2019 (COVID-19) disease, but the vaccine can result in immune activation and GVHD. Herein,
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Retroperitoneal Hematoma as an Atypical Presentation of Choriocarcinoma: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-02 Truce Pham,Danica Lapid,Kathleen M Schmeler,J Alejandro Rauh-Hain,Mateo G Leon
A 38-year-old female with an etonogestrel implant in place and history of previous ectopic pregnancy presented with acute abdominal pain and vaginal bleeding. She was found to have a beta-hCG of >12,000 mIU/mL and free fluid noted on a focused assessment with sonography in trauma exam. She underwent an emergent diagnostic laparoscopy due to the suspicion of a ruptured ectopic pregnancy. Findings at
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Rare Case of Advanced Gastric Cancer Complicated with Fibrinogen Storage Disease Treated with Chemotherapy plus Immune Checkpoint Inhibitor: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-02 Daiki Kawaguchi,Takeshi Kawakami,Yuko Kakuda,Kentaro Yamazaki
The administration of chemotherapy to cancer patients with organ dysfunction raises concerns regarding its safety. The safety profile of patients with organ dysfunction due to rare diseases treated with chemotherapy plus immune checkpoint inhibitor is limited. Fibrinogen storage disease (FSD) is a rare disease that causes liver dysfunction through endoplasmic reticulum stress response due to abnormal
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Exceptional Response to Pembrolizumab in a Mismatch Repair-Deficient Aggressive Prostate Cancer with Somatic EPCAM, MSH2, and MSH6 Co-Deletion: A Case Report. Case Rep. Oncol. Pub Date : 2023-11-02 Dennis Hoch,Manuela Rabaglio,Tobias Grob,Michael von Gunten,Jörg Beyer,Dilara Akhoundova
Mismatch repair-deficient (dMMR) prostate cancer (PCa) is a rare (1-5%) but highly actionable molecular subgroup of PCa, vulnerable to immune checkpoint inhibitors. Our case of sporadic dMMR PCa due to large monoallelic co-deletion of EPCAM, MSH2, and MSH6 features a clinically aggressive disease presentation and a major response to pembrolizumab. We report a 65-year-old patient with primary metastatic
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Invasive Cystic Hypersecretory Ductal Carcinoma of Breast: Challenges in Diagnosis and Management. Case Rep. Oncol. Pub Date : 2023-11-01 Noof Alshaibani,Janaki Krithika Chandramohan,Sara Salah Khairi,Fatima Al-Hashimi,Aysha Anwar Aljawder
Cystic hypersecretory lesions of the breast are a spectrum of conditions ranging from cystic hypersecretory hyperplasia with atypia and invasive cystic hypersecretory carcinoma (CHC). It is a subtype of ductal carcinoma of the breast. The tumour is very infrequent and hence, extensive literature is limited. This culminates in the fact that it does not feature as part of the WHO classification of breast
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Esophageal Adenocarcinoma: An Unusual Pericardial and Pulmonary Metastasis - A Case Report. Case Rep. Oncol. Pub Date : 2023-10-31 Waqas Rasheed,Omer Usman,Obaid Ur Rehman,Eeshal Fatima,Abdulqadir Nashwan
Introduction Esophageal adenocarcinoma (EAC) manifests in the glandular cells present in the lining of the esophagus and usually forms in the distal portion of the esophagus. The metastasis of EAC has been reported to occur in surrounding lymphovascular structures, the liver, brain, and bones. Case Presentation We present the rare case of a 52-year-old Hispanic male with EAC metastasis to the pericardium
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Downstaging and Pathological Complete Response of Locally Recurrent Sarcomatoid Renal Cell Carcinoma under Pembrolizumab and Lenvatinib: A Case Report and Review of Literature. Case Rep. Oncol. Pub Date : 2023-10-30 Jascha Ell,Philipp Balz,Panagiota Manava,Clemens Hüttenbrink
The advent of immune checkpoint inhibition opened new perspectives for patients with recurrent or metastasized renal cell carcinoma. In case of recurrent disease, surgical resection remains the most promising therapeutic option. Surgical resection is associated with improved overall survival and demonstrated curative potential given complete resection of metastases can be performed. This report presents
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Two Cases of Exacerbation of Asthma during Treatment with Enfortumab Vedotin. Case Rep. Oncol. Pub Date : 2023-10-25 Takamasa Homma,Kuniaki Tanaka,Naoya Takeda,Yu Okada,Shota Torii,Hideki Esaki,Takashi Sakakibara,Norio Takimoto
Enfortumab vedotin is an antibody-drug conjugate against nectin-4 that is recently being used in the management of patients with urothelial carcinoma. The common adverse events include rashes, peripheral neuropathy, and hyperglycemia. Only a few cases of associated respiratory symptoms have been reported. Herein, we describe 2 patients with advanced urothelial carcinoma who experienced asthma exacerbation
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Re-Irradiation after Radical Dose Radiotherapy: A Case Report Challenging an Established Dogma. Case Rep. Oncol. Pub Date : 2023-10-20 Lee Na Chong,Thomas Michael Hughes
Traditionally, external beam radiation therapy has a dogma pronouncing that re-irradiation of a region previously exposed to radical dose radiotherapy is contraindicated due to unacceptable risk to surrounding tissues. This edict is often zealously maintained to the detriment of certain, carefully selected patients that may benefit from re-irradiation. Liposarcoma is a high-grade malignancy with a
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A Rare Association of Mixed Autoimmune Hemolytic Anemia with Gastric Carcinoma. Case Rep. Oncol. Pub Date : 2023-10-20 Anu Chinnadurai,Scott Strum,Artin Ghassemian,Dalilah Fortin,Cheryl Foster,Daniel Breadner
This case report outlines a 70-year-old female patient who presented with a concurrent mixed autoimmune hemolytic anemia (AIHA) and a gastric adenocarcinoma. Her treatment course of these two diseases is summarized, which included supportive care, neoadjuvant chemotherapy for her gastric adenocarcinoma, steroids, rituximab, and surgical resection of the tumor. This approach ultimately led to the stabilization
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Trocar Site Recurrence after Laparoscopic Cholecystectomy for Unsuspected Isolated Gallbladder Metastasis of Melanoma: A Case Report and Review of the Literature. Case Rep. Oncol. Pub Date : 2023-10-18 Céline Sergeant,Joseph Kerger,Annie Drowart,François Sales,Mireille Langouo
Cutaneous melanoma can metastasize to almost any organ, including in-transit metastases, lymph nodes, liver, lungs, brain, and bones. Spread to the gastrointestinal tract is less common and generally concerns the small bowel, colon, and stomach. Gallbladder involvement is rarer, and only few cases describe it as the sole site of metastasis upon diagnosis. Melanoma metastases to the gallbladder are
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Gastric Conduit Cancer following Ivor-Lewis Esophagectomy for Esophageal Adenocarcinoma: A Case Report and Literature Review. Case Rep. Oncol. Pub Date : 2023-10-18 Tatyana Khorobrykh,Ivan Ivashov,Alexey Spartak,Juliet Babayan,Andrey Andriyanov,Pavel Pavlov
The incidence of gastric cancer associated with esophageal cancer is notably high. In recent years, there has been an increase in patients with gastric conduit cancers due to early detection and radical treatment of esophageal cancer, leading to prolonged survival of the patients. Metachronous gastric cancer following esophagectomy sometimes can pose a clinical challenge for surgeons, while gastric
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Deficient Mismatch Repair Proteins in Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasm: A Rare Case Report. Case Rep. Oncol. Pub Date : 2023-10-17 Thi Hong Chuyen Nguyen,Bao Song Nguyen Tran,Thanh Phuc Nguyen,Thi Minh Thi Ha,Nguyen Cuong Pham,Thu Giang Thi Nguyen,Huu Hoang,Thuan Dang Cong
Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare type of gastric carcinoma with controversial diagnosis and treatment. Recent data implies that deficiency mismatch repair proteins inducing microsatellite instability are considered one of the potential drivers of this disease. Hence, we report a stomach MiNEN with MMR protein loss. An admitted 60-year-old woman complained of epigastric
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Localized Multifocal Retroperitoneal Ganglioneuroma with an Infiltrative Appearance on Imaging: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-16 Joseph M Rich,Vinay A Duddalwar,Manju Aron,Ramon Ter-Oganesyan,Peter Hu,Shefali Chopra,Phillip M Cheng
Multifocal ganglioneuromas are characterized by the presence of multiple benign neuroepithelial tumor nodules and are less common than solitary tumors. A small percentage of ganglioneuromas present with a fatty appearance. Only a few cases of multifocal ganglioneuromas have been reported, due to both their rarity and minimal symptomatic presentation; therefore, generalizations about risk factors and
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Cystoid Macular Edema following Treatment with Nanoparticle Albumin-Bound Paclitaxel and Atezolizumab for Metastatic Breast Cancer. Case Rep. Oncol. Pub Date : 2023-10-16 Hiroaki Yamane,Tomoko Itagaki,Keiko Kajitani,Yuji Koura,Yoshiharu Kawabuchi,Masahiro Ohara
Cystoid macular edema (CME) is a rare side effect associated with chemotherapy. Although the development of CME has been reported to occur following treatment with taxane drugs, such as nanoparticle albumin-bound paclitaxel (Nab-PTX), the occurrence of CME with treatment with atezolizumab has not yet been reported. Here, we report the case of a 49-year-old woman who developed CME 19 months into chemotherapy
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Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab. Case Rep. Oncol. Pub Date : 2023-10-16 Amrita Ladwa,Omar Elghawy,Anneke Schroen,Kristan Abernathy,Jenna Schlefman,Patrick Dillon
Metaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriamycin, and cyclophosphamide in a neo-adjuvant fashion. The radiographic and histologic findings of the
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Case Series: Cemiplimab and Nivolumab Immunotherapy as Promising Treatment in Advanced or Metastatic Cutaneous Squamous Cell Carcinoma. Case Rep. Oncol. Pub Date : 2023-10-16 Fei Ya Lai,Rachel Clarke,Patrick Cooper,John Stokes,Paula Calvert
Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Surgery is usually curative; however, some locally advanced or metastatic CSCC may be unresectable. Current novel therapeutic options with immune checkpoint inhibition (ICI) of programmed-death receptor 1 (PD-1) such as cemiplimab and nivolumab have demonstrated promising and sustained results with good tolerability in
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Acanthosis Nigricans in a Patient with Urothelial Carcinoma Treated with PD-L1 Inhibitor Avelumab, and Secondary Adrenal Insufficiency. Case Rep. Oncol. Pub Date : 2023-10-16 Fei Ya Lai,Emmet Jordan
Acanthosis nigricans (AN) describes hyperkeratotic and hyperpigmented skin changes and its pathophysiology is linked to the activation of epidermal growth factor receptors. Current literature shows that AN is most commonly diagnosed at the time of the underlying pathology, which may occur under benign or malignant conditions. This case presentation demonstrates the occurrence of AN in a patient following
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Inflammatory Myofibroblastic Tumor in the Adrenal Gland: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-16 Reiko M Rodriguez-Nakamura,Martin Sanchez-Garcia,Arturo Del-Valle Rivera,Elizabeth Mota-Garduño,Leonora Chávez Mercado,Sergio Adolfo Espinoza Guibarra,Omar Vasquez-Gomez
Inflammatory myofibroblastic tumors (IMTs) were first described by Harold Brunn in 1939. IMTs are mainly found in the lungs and other sites of the body; hence, its occurrence in the adrenal gland is exceptional. In the literature, less than 10 cases of IMTs in the adrenal gland have been reported. The etiology of IMT remains unknown, with post-inflammatory changes and a neoplastic origin being proposed
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Successful Combination of Olaparib and 225Ac-Dotatate in a Patient with Neuroendocrine Tumor G3 and BRCA Mutation. Case Rep. Oncol. Pub Date : 2023-10-16 Anke Kröcher,Gunnar Folprecht,Robert Winzer,Mildred Sergon,Martin Bornhäuser,Jörg Kotzerke,Claudia Brogsitter
Based on the results of the NETTER-1 trial, peptide receptor radionuclide therapy with Lutetium-177 (177Lu) - DOTATATE is authorized for the treatment of neuroendocrine tumors (NET) grade 1 (G1) and grade 2 (G2) of the intestine. After the failure of 177Lu-DOTATATE therapy, targeted alpha-particle therapy (TAT) may be a possible treatment option. Here, we present a patient with cancer of unknown primary
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Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-16 Mohammad Abu-Jeyyab,Hanan Al-Asbahi,Mohammad Al-Jafari,Bushra Khalaf Al-Tarawneh,Abdulqadir J Nashwan
Mesenteric fibromatosis (MF) is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the potential to metastasize. It is spontaneous or associated with familial adenomatous polyposis (FAP])
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An Intestinal Type Gastric Neuroendocrine Tumor: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-16 Mohammad Abu-Jeyyab,Renata Kakish,Malak Alkatib,Leen Alshawabkeh,Rawan Bani Hamad,Mary Almadani,Ma'wia Santarisi,Mohammad Al-Jafari,Abdulqadir J Nashwan
Neuroendocrine tumors (NETs) represent a diverse set of malignancies, originating from the neuroendocrine cells dispersed throughout the body. Their symptoms are associated with the secretion of bioactive peptides by tumor cells. Five-year survival rates depend on the disease stage: 93% for local, 74% for regional, and 19% for metastatic disease. This report describes a case involving a 64-year-old
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Successful Rechallenge with Osimertinib following Osimertinib-Induced Ventricular Tachycardia: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-11 Zentaro Saito,Takuma Imakita,Takanori Ito,Issei Oi,Osamu Kanai,Kohei Fujita,Hiromasa Tachibana,Tadashi Mio
Osimertinib, a third-generation tyrosine kinase inhibitor, is the first-line treatment for metastatic non-small cell lung cancer (NSCLC) with sensitizing epidermal growth factor receptor (EGFR) mutations. It is known to cause drug-induced cardiotoxicity, including QT prolongation syndrome, heart failure, and ventricular arrhythmias, which can lead to sudden death. Once severe arrhythmias occur, it
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Combination of Osimertinib with Concurrent Chemotherapy and Hormonal Therapy for Synchronous NSCLC, Hormone Receptor-Positive Breast Cancer, and Triple-Negative Breast Cancer: Case Report. Case Rep. Oncol. Pub Date : 2023-10-11 Changsu L Park,Feras Moria,Ramy R Saleh
Patients presenting with multiple primary malignancies remain a growing challenge for physicians due to a lack of data for generalizable guidelines. Identification of driver mutations in carcinogenesis leads to the development of targeted treatment of many different cancer types, but its combination with other anti-cancer therapy is not well understood. We report a case of a 66-year-old woman who presented
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Sjögren's Syndrome Caused by PD-1 Inhibition in a Lung Cancer Patient. Case Rep. Oncol. Pub Date : 2023-10-11 Aaron Caeyman,Olivia Vandekerckhove,Karin Pat,Jokke Wynants,Karolien Weytjens,Isabelle de Wergifosse,Kristof Cuppens
In this report, we present a patient with metastatic non-small cell lung cancer who developed Sjögren's syndrome secondary to immune checkpoint inhibition. This patient had a typical clinical presentation as well as biochemical signature, developing only 18 months after the start of treatment with PD-1 inhibition (pembrolizumab).
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Giant Mature Ovarian Cystic Teratoma in a Pediatric Patient: Case Report and Literature Review. Case Rep. Oncol. Pub Date : 2023-10-06 Adolfo Eduardo Barragán-Curiel,Carlos Murillo-Zepeda,Karla Fernanda Castro-Perez,Francisco Omar Alcalá-Aguirre,Lilian Sabinne Diaz-Montoya,Omar Alfonso Ruiz-Félix,José Antonio Acevedo-Delgado,Moyra Velasco-Preciado
Mature cystic teratomas, also called dermoid cysts, are the most common germ-cell ovarian neoplasms in children. On average, ovarian dermoid cysts are slow-growing neoplasms with a mean size between 6.4 and 7.0 cm that enlarge at a rate of 1.8 mm/year; however, these can reach large dimensions. Giant ovarian tumors are defined as those having a maximum diameter equal to or more than 15 cm; these represent
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Spontaneous Remission in a Patient with Chronic Myeloid Leukemia: A Case Report. Case Rep. Oncol. Pub Date : 2023-10-06 Awni Alshurafa,Yeslem Ekeibed,Susanna Akiki,Muna Alzeyara,Zafar Nawaz,Mohamed A Yassin
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm in which granulocytic cells are the main proliferative component. At diagnosis, more than 90% of CML cases have the characteristic Philadelphia chromosome, containing the BCR::ABL1 fusion gene. The natural history of untreated CML is an initial indolent chronic phase which will be followed by an accelerated phase, blast phase, or both
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A Case of Tumor Lysis Syndrome during Palliative Radiotherapy for Breast Cancer Metastases. Case Rep. Oncol. Pub Date : 2023-10-02 Mitsuhiro Furusawa,Kozue Matsuishi,Kei Horino,Hideki Inoue,Michio Abe,Natsuo Oya
Tumor lysis syndrome (TLS) is the rapid disintegration of a malignant tumor treated with anticancer drugs or radiation, causing electrolyte abnormalities such as elevated uric acid levels, elevated potassium and phosphorus levels, and decreased calcium levels. These abnormalities can lead to hypotension, renal dysfunction, consciousness disorders, and even death in some cases. The current patient was
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Miliary Tuberculosis during R-MPV Therapy in an Elderly Patient with Primary Central Nerve System Lymphoma: A Case Report. Case Rep. Oncol. Pub Date : 2023-09-29 Yushiro Take,Mitsuaki Shirahata,Jun Sakai,Yuichi Kubota,Tomonari Suzuki,Jun-Ichi Adachi,Shigefumi Maesaki,Kazuhiko Mishima,Ryo Nishikawa
Most elderly patients with tuberculosis (TB) have previously been infected with Mycobacterium tuberculosis, which remains dormant in the body for decades and may reactivate when their immunity declines due to underlying diseases. Elderly cancer patients are at a high risk for TB, and the treatment of TB reactivation in these patients is challenging. Among cancer patients, the incidence of TB reactivation
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Endobronchial Metastasis of Renal Cancer Presented as Atelectasis. Case Rep. Oncol. Pub Date : 2023-09-27 Jae Hyung You,Young Beom Jeong
The most common primary tumors associated with endobronchial metastasis (EBM) are colorectal, breast, and renal. When EBM is present, respiratory symptoms such as shortness of breath or hemoptysis accompanied by coughing usually appear. Herein, we report a case of atelectasis caused by EBM of renal cell carcinoma (RCC) in a 53-year-old man who underwent laparoscopic radical nephrectomy for RCC 5 years