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Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-05 David Luengo, Ángela Salmerón, Antonio Medina, Javier Pastor, Mercedes Caba
Retroperitoneal fibrosis, a rare and often idiopathic condition, poses significant diagnostic challenges. While most cases are considered idiopathic or immune-mediated, a small but important proportion are associated with malignant neoplasms, with implications for prognosis and management. The present study describes the case of a 69-year-old man who presented to the emergency department of the Virgen
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Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-05 Hua Ye, Wenwen Yu, Yangyang Ni, Xiaoqiong Bao, Xie Zhang, Yunlei Li, Ali Chen, Jifa Li, Long Zheng
Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of apatinib plus chemotherapy in patients with advanced LUAD. A total of 145 patients with advanced LUAD and negative driver genes who received apatinib plus chemotherapy
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Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Qian Ma, Bai Wei, Bi-Cheng Wang, Ganxin Wang, Xuan Zhou, Yan Wang
As a novel tyrosine kinase inhibitor (TKI), pyrotinib can irreversibly block dual pan-ErbB receptors and has been used in the treatment of advanced or metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, there are limited data on the use of pyrotinib in early breast cancer. Therefore, the present meta-analysis was conducted to evaluate the safety and efficacy
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Prognostic biomarker HIF1α and its correlation with immune infiltration in gliomas. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Zihan Ding, Jiaming Zhang, Lin Li, Chunliang Wang, Jinhong Mei
Certain glioma subtypes, such as glioblastoma multiforme or low-grade glioma, are common malignant intracranial tumors with high rates of relapse and malignant progression even after standard therapy. The overall survival (OS) is poor in patients with gliomas; hence, effective prognostic prediction is crucial. Herein, the present study aimed to explore the potential role of hypoxia-inducible factor
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[Retracted] Correlation of SOX9 and NM23 genes with the incidence and prognosis of prostate cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Ming Xi, Song Wan, Wei Hua, Yulin Zhou, Wencong Jiang, Jianxin Hu
[This retracts the article DOI: 10.3892/ol.2018.9828.].
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Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-01 Zhenyu Bi, Jinghao Zhou, Yan Ma, Qingxin Guo, Boyang Ju, Haoran Zou, Zuhao Zhan, Feihong Yang, Han Du, Xiuguo Gan, Erlin Song
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as
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Prognostic value of tumor‑associated CD177+ neutrophils in lung adenocarcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-01 Jinhua Zhou, Qingxia Xu, Huan Liu, Jianlong Miao, Cuixia Bian, Yutao Wei, Wei Wang, Shulong Jiang
The aim of the present study was to detect CD177+ neutrophils in tumor tissues and analyze their association with the clinical characteristics and prognosis of patients with lung adenocarcinoma (LUAD). Immunohistochemistry was used to detect CD177+ neutrophils in tumors and adjacent tissues of 16 patients with LUAD who underwent curative surgical resection. A total of 120 patients with LUAD were recruited
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Diagnostic performance of 18F‑DCFPyL PET vs. 68Ga‑PSMA PET/CT in patients with suspected prostate cancer: A systemic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Zhibing Jiang, Jinjing Guo, Liang Hu, Siyu Yang, Bin Meng, Qun Tang
In this systematic review and meta-analysis, the diagnostic performance of 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT was compared with that of 18F-DCFPyL PET for patients with suspected prostate cancer (PCa). Up to September 2023, the PubMed, Embase and Web of Science databases were thoroughly searched for relevant papers. Studies examining the diagnostic
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Adrenal ganglioneuroblastoma with metastasis near the renal hilum in an adult female: A case report and review of the literature. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Xinzhang Zhang, Yiwen Zhang, Dan Peng, Xin Shi, Zhuorui Zhang, Junfeng Wang, Xue Zhang, Jinjun Leng, Wei Li
Ganglioneuroblastoma (GNB), predominantly observed in children, is an uncommon malignant tumor in adults, with established treatment protocols notably lacking. The present study details the case of a 20-year-old woman who presented with a left adrenal gland mass, identified during a physical examination. Additionally, an unidentified mass was noted near the renal hilum in the preoperative evaluation
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Identification and prognostic analysis of ferroptosis‑related gene HSPA5 to predict the progression of lung squamous cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Di Guo, Yonghai Feng, Peijie Liu, Shanshan Yang, Wenfei Zhao, Hongyun Li
Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, is implicated in the development and therapeutic responses of cancer. However, the role of ferroptosis-related gene profiles in lung squamous cell carcinoma (LSCC) remains largely unknown. The present study aimed to identify the prognostic roles of ferroptosis-related genes in LSCC. Sequencing data from
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Cushing's syndrome caused by adrenocortical oncocytoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Chengren Gou, Qingsong Jian, Maoqiang Tian, Jinghai Li, Yi Zhang, Zhenyu Guo
Adrenal cortical eosinophilic adenoma usually presents as non-functional adrenal tumor but may lead to Cushing's syndrome in patients. The present article reports a patient with Cushing's syndrome caused by right adrenocortical oncocytoma. The patient was treated in Urology Department of Wuchuan People's Hospital (Zunyi, China) in November 2022 because of hirsutism, weight gain and hypertension. A
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Influence of Zika virus on the cytotoxicity, cell adhesion, apoptosis and inflammatory markers of glioblastoma cells. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Daniel Rodrigo Marinowic, Gabriele Goulart Zanirati, Pamella Nunes Azevedo, Ângela Zanatta, Ismael Plentz, Allan Marinho Alcará, Fernanda Bueno Morrone, Thamiris Becker Scheffel, Angélica Regina Cappellari, Paulo Michel Roehe, Ana Paula Muterle Varela, Denise Cantarelli Machado, Fabiana Spillari Viola, Jaderson Costa Da Costa
Glioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells
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Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Lili Gong, Gang Hu, Lihua Xu, Yajuan Chen, Na Wang
Multidrug resistance 1 (MDR1) is a transmembrane transporter on the cell membrane. As an ATP-dependent efflux pump, MDR1 is mainly responsible for the adsorption, distribution, metabolism, excretion and transportation of anticancer drugs to cancer cells. Mutations of the MDR1 gene may be associated with the incidence of cancer. In the past decade, associations found between the MDR1 rs1045642 polymorphism
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The landscape of 8q24 cytoband in gastric cancer (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Violeta Larios-Serrato, Hilda-Alicia Valdez-Salazar, Martha-Eugenia Ruiz-Tachiquín
Worldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24
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Liquid biopsy utilizing miRNA in patients with advanced breast cancer treated with cyclin‑dependent kinase 4/6 inhibitors. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Marcin Kubeczko, Patrycja Tudrej, Tomasz Tyszkiewicz, Aleksandra Krzywon, MaŁgorzata Oczko-Wojciechowska, MichaŁ JarzĄb
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer (ABC). Despite improvements in overall survival, most patients experience disease progression. Biomarkers derived from a liquid biopsy are appealing for their potential to detect resistance to treatment earlier than computed
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Multi‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Xianhai Zhang, Zhifeng Xu, Yabin Jin, Linwen Huang, Wenxiu Wu, Mingyong Gao
The present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All
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[Retracted] miR‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-26 Yonggen Zou, Jiexiang Yang, Jian Wu, Cheng Luo, Yuanshuai Huang
[This retracts the article DOI: 10.3892/ol.2017.7432.].
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A meta‑ and bioinformatics analysis of maspin expression levels influencing the prognosis of patients with breast cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-23 Shuai Shi, Zhi-Gang Zhang, Yin-Zhou Sang, Jie Sun, Hong-Yan Ma
Maspin is a serine protease inhibitor that is encoded by the human SERPINB5 gene. As a tumor inhibitor, it can inhibit the growth of tumor cells, increase adhesion between tumor cells and inhibit tumor angiogenesis. In the present study, a meta- and bioinformatics analysis was performed through the PubMed and China National Knowledge Infrastructure databases including entries added until up to March
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Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-20 Tingting Jiang, Yan Liang, Yenan Ji, Yin Xue
Cisplatin resistance is ubiquitous among patients with renal cell carcinoma (RCC). The present study assessed the role of fisetin in regulating cisplatin sensitivity and increasing the efficacy of chemotherapy for patients with RCC. Cell Counting Kit-8 and colony formation assays were used to assess the proliferation of RCC cells after fisetin and cisplatin treatment. The mRNA expression levels of
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Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-20 Lina Wang, Xi Pang, Zirui Hong, Baodong Ye, Zhiping Hu, Chunli Zhang, Shuyan Liu
At present, to the best of our knowledge, there are only a few case reports of IgG4-related disease (IgG4-RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4-RD is increasing in middle-aged and elderly people. The present study presents a case of MDS combined with IgG4-RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66-year-old; male)
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[Retracted] Long non‑coding RNA MALAT‑1 contributes to maintenance of stem cell‑like phenotypes in breast cancer cells. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Linghuan Zeng, Ying Cen, Junjie Chen
[This retracts the article DOI: 10.3892/ol.2017.7557.].
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Indolent growth of low‑grade myofibroblastic sarcoma of the knee with the resemblance of a benign lesion: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Tao Cheng, Shaohua Liang, Jinli Zhang, Wen Wang
Low-grade myofibroblastic sarcoma (LGMS) is a rare soft-tissue malignant neoplasm originating from the stromal cells that is predominantly comprised of atypical myofibroblasts. The present study reports the case of a patient with low-grade myofibroblastic sarcoma in the soft tissue of the knee. The patient exhibited a soft, painless mass on the medial side of the left knee. During surgery, a yellow-white
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Prognostic role of primary tumor size in Wilms tumor. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Kai Li, Ke Zhang, Hexing Yuan, Caibin Fan
Wilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the
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Repeated high‑intensity focused ultrasound combined with iodine‑125 seed interstitial brachytherapy offers improved quality of life and pain control for patients with advanced pancreatic cancer: A 52‑patient retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-16 Yumei Liu, Yongshuo Ji, Junqiu Zhu, Linglin Zhu, Yanfei Zhu, Zhijun Bao, Hong Zhao
Patients diagnosed with pancreatic cancer who have 5-year survival rates of ~5% are typically in the advanced stage. Pancreatic cancer has become the third leading cause of cancer-related death in the United States and there is still a lack of effective treatments to improve patient survival rate. Hence, the purpose of the present retrospective study was to assess the potential clinical impact of repeated
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Exploring miRNA‑target gene profiles associated with drug resistance in patients with breast cancer receiving neoadjuvant chemotherapy. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-16 Min Woo Kim, Sol Moon, Suji Lee, Hyojung Lee, Young Kim, Joon Ye Kim, Jee Ye Kim, Seung Il Kim
Exosomal microRNAs (miRNAs) are closely related to drug resistance in patients with breast cancer (BC); however, only a few roles of the exosomal miRNA-target gene networks have been clinically implicated in drug resistance in BC. Therefore, the present study aimed to identify the differential expression of exosomal miRNAs associated with drug resistance and their target mRNAs. In vitro microarray
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Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-15 Linhao Ran, Ying Liu, Li Jiang
Testicular seminoma is a relatively rare malignant tumor, with the most common site of recurrence and metastasis being the retroperitoneal lymph nodes. Since seminoma is highly sensitive to radiotherapy and chemotherapy, even if it metastasizes, its cure rate is still >95%. However, the long-term toxicity and side effects of radiotherapy and chemotherapy cannot be ignored. Iodine-125 seeds represent
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Successful treatment of simultaneous malignant pleural mesothelioma and pulmonary adenocarcinoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-15 Yuki Amakusa, Tatsuro Suzuki, Yu Hikosaka, Masaya Takemura, Tetsuya Oguri
The present report described the case of a 74-year-old male patient with asbestos exposure whose chest computed tomography revealed a right lower lobe nodule and right pleural effusion. Pleural biopsy led to the diagnosis of epithelial malignant pleural mesothelioma (cT2N0M0, stage IB). Combination therapy with cisplatin + pemetrexed led to the complete remission of malignant pleural mesothelioma;
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Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-14 Liping Ren, Danni Huang, Hongjiang Liu, Lin Ning, Peiling Cai, Xiaolong Yu, Yang Zhang, Nanchao Luo, Hao Lin, Jinsong Su, Yinghui Zhang
Gastric cancer (GC) is a prominent contributor to global cancer-related mortalities, and a deeper understanding of its molecular characteristics and tumor heterogeneity is required. Single-cell omics and spatial transcriptomics (ST) technologies have revolutionized cancer research by enabling the exploration of cellular heterogeneity and molecular landscapes at the single-cell level. In the present
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Effectiveness of immune checkpoint inhibitors in combination with tyrosine kinase inhibitors in patients with advanced or metastatic colorectal carcinoma with either mismatch repair proficient or metastatic microsatellite stable disease: A systematic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-14 Ji Li, Jin-Xian Zhu, Yu-Xin Zhang, Shi-Qiang Li
Immune checkpoint inhibitors (ICIs) have limited efficacy in mismatch repair proficient (pMMR) or metastatic microsatellite stable (MSS) advanced or metastatic colorectal cancer (mCRC). ICIs, in conjunction with tyrosine kinase inhibitors (TKIs) possessing anti-angiogenic properties, serve as a potential strategy for circumventing the resistance exhibited by MSS or pMMR mCRC to immunotherapeutic interventions
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CFLAR: A novel diagnostic and prognostic biomarker in soft tissue sarcoma, which positively modulates the immune response in the tumor microenvironment. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-14 Xu Liu, Xiaoyang Li, Shengji Yu
Anoikis is highly associated with tumor cell apoptosis and tumor prognosis; however, the specific role of anoikis-related genes (ARGs) in soft tissue sarcoma (STS) remains to be fully elucidated. The present study aimed to use a variety of bioinformatics methods to determine differentially expressed anoikis-related genes in STS and healthy tissues. Subsequently, three machine learning algorithms, Least
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Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-14 Dan Zhang, Jingjing Jin, Jianying Dou, Yan Huang, Haibo Zhang
Lung cancer is a prevalent and highly lethal disease often complicated by lower respiratory tract infections. Microbial patterns in these infections vary based on treatment modalities. The present study explored the impact of lung cancer treatments on pathogens and clinical characteristics in the presence of lower respiratory tract infections to inform antimicrobial drug selection. A retrospective
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[Retracted] Clinical significance of miR‑1298 in cervical cancer and its biological function in vitro. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-12 Haitao Zhang, Ruihong Zhang, Guiling Zhang, Wenjuan Liu, Zhaoyuan Ma, Caiyun Yue, Min Yang
[This retracts the article DOI: 10.3892/ol.2021.12662.].
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Pathological features of gastric‑type endocervical adenocarcinoma: A report of two cases. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-09 Jiahui Zhou, Xiangning Zhang, Weibo Mao, Yiling Zhu, Liping Yan, Jiangle Jiang, Min Zhang
Gastric-type endocervical adenocarcinoma (GEA) is an uncommon form of uterine cervical adenocarcinoma with an unfavorable prognosis. The tumor consists of glands exhibiting a morphological resemblance to gastric cells and occasionally manifests features akin to pancreaticobiliary mucinous adenocarcinoma. GEA differs from the typical cervical cancer, particularly in its lack of association with the
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Occult urothelial carcinoma with mediastinal metastasis: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-09 Jingfan Zheng, Xintong Peng, Xiaoqing Li, Yuyu Chen, Xinyi Li, Ling Fu, Ao Li, Zhong Lu
Occult urothelial carcinoma (UC), particularly with mediastinal metastases, is an uncommon clinical occurrence. The present study describes the unusual case of a 70-year-old male patient who developed mediastinal metastases from an occult UC. Histological evaluations and immunohistochemical features of the mediastinal tumor were indicative of UC; however, extensive imaging failed to identify the primary
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Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-08 Tatsuhiko Kohno, Jun Kinoshita, Katsunobu Oyama, Hiroto Saito, Mari Shimada, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Noriyuki Inaki, Tetsuo Ohta
Reflux of gastroduodenal contents into the esophagus leads to the development of esophagitis and inflammation-associated pathologies, such as Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). The role of the lipoxygenase (LOX) pathway in carcinogenesis has been recently reported; however, its involvement in esophageal carcinogenesis remains unclear. To address this, the present study investigated
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Pilocytic astrocytoma: The paradigmatic entity in low‑grade gliomas (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-08 Cristina Pizzimenti, Vincenzo Fiorentino, Antonino Germanò, Maurizio Martini, Antonio Ieni, Giovanni Tuccari
Among low-grade gliomas, representing 10-20% of all primary brain tumours, the paradigmatic entity is constituted by pilocytic astrocytoma (PA), considered a grade 1 tumour by the World Health Organization. Generally, this tumour requires surgical treatment with an infrequent progression towards malignant gliomas. The present review focuses on clinicopathological characteristics, and reports imaging
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Recommendations for cyclin‑dependent kinase 4/6 inhibitor treatments in the context of co‑morbidity and drug interactions (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-08 Mehmet Teomete, Devrim Cabuk, Taner Korkmaz, Selcuk Seber, Ozge Fulya Ozturk, Birkan Aver, Atila Karaalp, Gul Basaran
Breast cancer is most frequently diagnosed among women aged 65-74 years and the prevalence of comorbidities in elderly patients with breast cancer is 32.2%. In addition, polypharmacy is quite common in these patients. Understanding the interaction between breast cancer treatment modalities and comorbidities is important, particularly in elderly patients, as comorbidities affect the choice of appropriate
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Implication of PD‑L1 polymorphisms rs2297136 on clinical outcomes of patients with advanced NSCLC who received PD‑1 blockades: A retrospective exploratory study. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-07 Qiang Gong, Hai-Ling Qie, Shao-Yong Dong, Hong-Tao Jiang
Clinically, programmed death-1 (PD-1) blockades have demonstrated promising therapeutic outcomes for patients with advanced non-small cell lung cancer (NSCLC). The present study aimed to examine the impact of programmed death-ligand 1 (PD-L1) polymorphism on clinical outcomes of patients with advanced NSCLC who were treated with PD-1 blockades therapy. The present study was designed as a retrospective
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Analysis of differentially expressed proteins in lymph fluids related to lymphatic metastasis in a breast cancer rabbit model guided by contrast‑enhanced ultrasound. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-06 Jiachao Xu, Xin Zhang, Guangfei Yang, Wei Sun, Wen Wang, Chengrong Mi
The aim of the present study was to identify differentially expressed proteins in the lymph fluid of rabbits with breast cancer lymphatic metastasis compared with healthy rabbits and to analyze and verify these proteins using proteomics technologies. In the process of breast cancer metastasis, the composition of the lymph fluid will also change. Rabbits with breast cancer lymph node metastasis and
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Patients with oral tongue squamous cell carcinoma and co‑existing diabetes exhibit lower recurrence rates and improved survival: Implications for treatment. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-06 Amir M Salehi, Lixiao Wang, Xiaolian Gu, Philip J Coates, Lena Norberg Spaak, Nicola Sgaramella, Karin Nylander
Locoregional recurrences and distant metastases are major problems for patients with squamous cell carcinoma of the head and neck (SCCHN). Because SCCHN is a heterogeneous group of tumours with varying characteristics, the present study concentrated on the subgroup of squamous cell carcinoma of the oral tongue (SCCOT) to investigate the use of machine learning approaches to predict the risk of recurrence
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[Retracted] Long non‑coding RNA SNHG6 promotes tumorigenesis in melanoma cells via the microRNA‑101‑3p/RAP2B axis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-05 Hong Zhou, Lingqiao Li, Yingqian Wang, Dewei Wang
[This retracts the article DOI: 10.3892/ol.2020.12186.].
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Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-02 Penghui Wang, Haifang Zhang, Kaikai Guo, Chun Liu, Shimin Chen, Baopeng Pu, Sirun Chen, Tong Feng, Hanyi Jiao, Chang Gao
Rapamycin is an immunosuppressant that has been shown to prevent tumor growth following organ transplantation. However, its exact mode of antitumor action remains unknown. The present study used the B16-F10 (B16) murine melanoma model to explore the antitumor mechanism of rapamycin, and it was revealed that rapamycin reduced B16 cell viability in vitro and in vivo. In addition, in vitro and in vivo
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Sustained response to anlotinib in advanced pancreatic neuroendocrine carcinoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-02 Yan Zhang, Yanchun Wang, Jingjing Wu, Zhihong Zhong, Jie Li, Xi Chen
Pancreatic neuroendocrine carcinoma (pNEC) is a type of pancreatic neuroendocrine neoplasm with a poor prognosis, and patients with metastatic pNEC have a survival time of only 8-12 months. The treatment options for pNEC are minimal, and the prognosis is unfavorable. The present study reports the case of a 56-year-old male who was diagnosed with advanced pNEC with bone metastases in June 2018. The
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Next‑generation sequencing to identify genetic mutations in pancreatic cancer using intraoperative peritoneal washing fluid. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-02 Yutaka Nakano, Gaku Shimane, Kohei Nakamura, Reika Takamatsu, Eriko Aimono, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Yohei Masugi, Minoru Kitago, Hiroshi Nishihara, Yuko Kitagawa
The efficacy of next-generation sequencing (NGS) of tumor-derived DNA from intraoperative peritoneal washing fluid (IPWF) of patients with pancreatic ductal adenocarcinoma (PDAC) who intend to undergo curative resection remains unclear. The aim of the present study was to evaluate whether genomic mutations in tumor-derived DNA from IPWF samples of patients with PDAC who intend to undergo curative resection
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Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-01 Jie Zhou, Ping Zhou, Jinfang Wang, Jie Song
Angiogenesis plays a crucial role in tumor growth and metastasis, and is heavily influenced by the tumor microenvironment (TME). Endothelial cell dysfunction is a key factor in tumor angiogenesis and is characterized by the aberrant expression of pro-angiogenic factors. Endothelial cell specific molecule-1 (ESM1), also known as endocan, is a marker of endothelial cell dysfunction. Although ESM1 is
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Clinical implications and predictive value of the creatinine‑cystatin C ratio in patients with multiple myeloma and renal impairment. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-31 Yixuan Sun, Junfeng Zhao, Jiachen Du, Ying Li, Fangjie Ding, Wenbo Zhao
The creatinine (Cr)-cystatin C ratio (CCR) at the time of cancer diagnosis is associated with survival; however, to the best of our knowledge, the association between this ratio and mortality in patients with multiple myeloma and renal impairment (RI) is unclear. Therefore, the present study aimed to assess this association, as well as disease prognosis and the clinical significance of the CCR in patients
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Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-31 Yi Zeng, Yudong Ling, Xiaojiang Chen, Chao Ding, Yukai Jin, Shoucheng Feng, Zhenchong Chen, Jianrong Guo, Haibo Qiu
For patients with gastrointestinal stromal tumors (GISTs) and liver metastases, there is still debate about whether radiofrequency ablation (RFA) or hepatectomy is preferable. The present study aimed to compare the clinical outcomes of RFA with hepatectomy in patients with GISTs and liver metastases. The present retrospective study consisted of a cohort of 43 patients who had been diagnosed with liver
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Inflammation‑based prognostic markers of metastatic pancreatic cancer using real‑world data in Japan: The Tokushukai REAl‑world Data (TREAD) project. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-31 Rai Shimoyama, Yoshinori Imamura, Kiyoaki Uryu, Takahiro Mase, Megumi Shiragami, Yoshiaki Fujimura, Maki Hayashi, Megu Ohtaki, Keiko Ohtani, Nobuaki Shinozaki, Hironobu Minami
Inflammation-based prognostic markers based on a combination of blood-based parameters, including the modified Glasgow prognostic score (mGPS), have been associated with clinical outcomes in patients with various types of cancer. The present study aimed to evaluate and compare the accuracy of these previously reported markers in patients with metastatic pancreatic cancer receiving first-line chemotherapy
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Efficacy of immune checkpoint inhibitors in advanced large cell neuroendocrine carcinoma of the lung: A single‑institution experience. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-31 Ningning Yan, Sanxing Guo, Ziheng Zhang, Shujing Shen, Xingya Li
Large cell neuroendocrine carcinoma (LCNEC) is a rare and highly invasive lung cancer subtype with an overall poor prognosis. Due to its low incidence rate and unusual pathological features, the clinical management of LCNEC remains controversial. The present study aimed to assess the effect of immune checkpoint inhibitors (ICIs) on treatment response and survival outcomes in patients with advanced
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Primary lymphoplasmacytic lymphoma of the larynx mimicking extramedullary plasmacytoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-30 Moeko Miyamori, Takaya Ichikawa, Naoya Inamura, Hana Takekawa, Kento Sakoda, Kazuyuki Yamada, Fumiyuki Suzuki
Primary haematological neoplasms of the larynx are uncommon; therefore, information regarding their epidemiology is limited and the diagnosis of histological types requires careful consideration. The current study describes the case of a 72-year-old male patient with primary laryngeal lymphoplasmacytic lymphoma (LPL) that was difficult to distinguish from plasmacytoma. Imaging examinations of the neck
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Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-30 Xiaona Su, Ci Zhou, Shu Chen, Qiang Ma, He Xiao, Qian Chen, Hua Zou
Immune checkpoint inhibitors (ICIs) combined with platinum-containing chemotherapy are recommended as the standard first-line treatment for non-small cell lung cancer (NSCLC). However, specific prognostic markers for this combination therapy are yet to be identified. Evaluation of circulating tumor cells (CTCs) and cell surface programmed death-ligand 1 (PD-L1) exhibits potential in predicting the
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Two tumor types in a unilateral testis in a patient with severe oligozoospermia and a history of cryptorchidism surgery: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-30 Hiroki Tsujioka, Kei-Ichiro Uemura, Akiyoshi Osaka, Toshiyuki Iwahata, Akiko Fujii, Shinichi Ban, Hiroshi Okada, Kazutaka Saito
Testicular cancer, the most common cancer among young male adults, is associated with infertility. A 38-year-old male patient was admitted to Dokkyo Medical University Saitama Medical Center, Japan, with infertility associated with severe oligozoospermia. Scrotal ultrasonography revealed two distinct tumors in the left testis: A mass with abundant blood flow on the cranial side and a mass with poor
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Atypical teratoid rhabdoid tumor in a lower middle‑income country: Challenges to cure. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-30 Ahmed El-Hemaly, Marwa Samir, Hala Taha, Amal Refaat, Eslam Maher, Mohamed El-Beltagy, Mohamed S Zaghloul, Alaa El-Haddad
Atypical teratoid rhabdoid tumor (ATRT) is a rare type of potentially fatal childhood brain tumor. The present study aimed to examine the overall survival (OS) and event-free survival (EFS) outcomes of pediatric patients with ATRT and to analyze the impact of different prognostic factors, including age, sex, tumor site and size, metastatic disease, the extent of resection, radiotherapy, and chemotherapy
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Knockdown of TFAP2E results in rapid G2/M transition in oral squamous cell carcinoma cells. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-29 Ryo Sakai, Kyoko Fujiwara, Eri Nagasaki-Maeoka, Yoshinori Inagaki, Bin Yamaoka, Eri Muto-Fujita, Yusuke Kamidaki, Tsugumichi Koshinaga, Shuichiro Uehara, Tadateru Takayama, Shuichi Sato
TFAP2E is a member of the activator protein-2 transcription factor family and acts as a tumor suppressor in several types of cancer. Downregulation of TFAP2E expression is significantly associated with a shorter overall survival period in patients with oral squamous cell carcinoma (OSCC). To evaluate the molecular mechanisms by which TFAP2E suppresses the development or progression of OSCC, the present
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Matrix metalloproteinase‑1 and microRNA‑486‑5p in urinary exosomes can be used to detect early lung cancer: A preliminary report. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-29 Wataru Ando, Masaya Sogabe, Shigemi Ishikawa, Takayuki Uematsu, Hiroyuki Furuya, Hiroaki Yokomori, Yutaka Kohgo, Katsuya Otori, Tomoyuki Nakano, Shunsuke Endo, Hiroyoshi Tsubochi, Isao Okazaki
The present study describes a novel molecular-genetic method suitable for lung cancer (LC) screening in the work-place and at community health centers. Using urinary-isolated exosomes from 35 patients with LC and 40 healthy volunteers, the expression ratio of MMP-1/CD63, and the relative expression levels of both microRNA (miRNA)-21 and miRNA-486-5p were measured. MMP-1/CD63 expression ratio was significantly
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[Retracted] LncRNA GAS6 antisense RNA 1 facilitates the tumorigenesis of clear cell renal cell carcinoma by regulating the AMP‑activated protein kinase/mTOR signaling pathway. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-29 Xiaoyun Guo, Hongjun Li, Mei Zhang, Rong Li
[This retracts the article DOI: 10.3892/ol.2021.12988.].
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Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-26 Terufumi Yoshida, Kazuko Sakai, Masaki Kaibori, Mitsuaki Ishida, Shogo Tanaka, Shoji Kubo, Takuya Nakai, Marco A De Velasco, Hideyuki Matsushima, Koji Tsuta, Mitsugu Sekimoto, Kazuto Nishio
Sarcomatoid hepatocellular carcinoma (SHCC) is a rare and highly lethal subtype of HCC. The present study aimed to explore the unique markers of SHCC using whole gene expression analysis. Subsequently, gene expression analysis was performed using five sarcomatoid and seven carcinomatoid components of seven tissues from patients with SHCC. The results demonstrated a significant downregulation of polybromo
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The influence of radiological tumor growth pattern on sino‑nasal health in pituitary adenomas. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-26 Sebastian Walbrodt, Karsten H Wrede, Witold X Chmielewski, Thiemo Florin Dinger, Maximilian Schüβler, Cornelius Deuschl, Mehdi Chihi, Hanah Hadice Gull, Ramazan Jabbarli, Marvin Darkwah Oppong, Annika Lenkeit, Anne-Kathrin Uerschels, Oliver Gembruch, Ilonka Kreitschmann-Andermahr, Björn Scheffler, Ulrich Sure, Yahya Ahmadipour
Pituitary adenomas are one of the most common mass lesions of the brain and are associated with a reduced quality of life. While transnasal and transsphenoidal endoscopic approaches are considered to deliver similar recovery rates for sino-nasal health (SNH), the impact of radiological tumor growth patterns on SNH has not been evaluated. In the present study, the influence of radiological tumor growth
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Multidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-25 Koichi Okamoto, Takahisa Yamaguchi, Tetsuya Asakawa, Daisuke Kaida, Takashi Miyata, Tomoyuki Hayashi, Toshihiko Ojima, Hideto Fujita, Noriyuki Inaki, Shinichi Kinami, Itasu Ninomiya, Hiroyuki Takamura
A gastric inlet patch (GIP) is an ectopic gastric mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To the best of our knowledge, this is the first case of a GIP-derived EAC that was successfully treated using a multidisciplinary treatment approach. A 64-year-old man was referred to the Department of Gastrointestinal Surgery, Kanazawa University
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Single‑agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation. Oncol. Lett. (IF 2.9) Pub Date : 2024-01-25 Takatsune Shimizu, Atsunobu Sagara, Yumi Fukuchi, Akihiro Muto
New therapeutic approaches are needed for osteosarcoma, which is the most common malignancy of the bone, especially for metastatic cases. Nintedanib is a potent, oral tyrosine kinase inhibitor approved for treating idiopathic pulmonary fibrosis, which blocks a variety of receptor signals, including fibroblast growth factor receptors, vascular endothelial growth factor receptors and platelet-derived