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Exploring the relation of active surveillance schedules and prostate cancer mortality Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Zhenwei Yang, Eveline A. M. Heijnsdijk, Lisa F. Newcomb, Dimitris Rizopoulos, Nicole S. Erler
Active surveillance (AS), where treatment is deferred until cancer progression is detected by a biopsy, is acknowledged as a way to reduce overtreatment in prostate cancer. However, a consensus on the frequency of taking biopsies while in AS is lacking. In former studies to optimize biopsy schedules, the delay in progression detection was taken as an evaluation indicator and believed to be associated
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Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms Cancer Med. (IF 4.0) Pub Date : 2024-03-18 Kelly S. Chien, Faustine Ong, Kunhwa Kim, Ziyi Li, Rashmi Kanagal-Shamanna, Courtney D. DiNardo, Koichi Takahashi, Guillermo Montalban-Bravo, Danielle Hammond, Koji Sasaki, Sherry A. Pierce, Hagop M. Kantarjian, Guillermo Garcia-Manero
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The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy Cancer Med. (IF 4.0) Pub Date : 2024-03-18 Yuki Tsutsumi, Kazuhiro Omura, Yoshikazu Kijima, Masao Kobayashi, Nei Fukasawa, Teppei Takeda, Teru Ebihara, Satoshi Aoki, Nobuyoshi Otori, Hiromi Kojima, Manabu Aoki
We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross-departmental collaboration to enhance the effectiveness of cancer treatment.
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Decreased interleukin‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Jeng‐Kai Jiang, Chi‐Hung Lin, Ting‐An Chang, Liang‐Chuan Lo, Chien‐Ping Lin, Ruey‐Hwa Lu, Chih‐Yung Yang
BackgroundInterleukin‐17 (IL‐17) is a pro‐inflammatory cytokine that plays a vital role in the promotion of tumorigenesis in various cancers, including colorectal cancer (CRC). Based on current evidence, IL‐17 binds to interleukin‐17 receptor A (IL‐17RA); however, the role of IL‐17RA has not been elucidated in previous studies on CRC. In this study, we explored the role of IL‐17RA in human CRC tissues
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Ultrasound‐guided percutaneous high‐frequency irreversible electroporation in porcine livers using four electrode needles: A feasibility and safety study Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Chang‐Tian Li, Guo‐Dong Zhao, Wen‐Bo Zou, Zhen‐Hua Zhang, Yi Zhao, Rong Liu
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Cancer incidence among Armenians in California Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Ani S. Movsisyan Vernon, Jeffrey S. Hoch, Laura Fejerman, Theresa H. Keegan
IntroductionCalifornia is home to the largest population of Armenians in the United States. The historical categorization of Armenians as ‘White’ or ‘Some Other Race’ in population databases has likely masked cancer incidence patterns in this population. This is the first study considering cancer incidence among Armenians in California.MethodsWe used the Armenian Surname List and birthplace information
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A survey of carboplatin desensitization therapy in Japan: A multicenter retrospective study Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Hiroaki Komatsu, Koji Matsumoto, Mitsunori Morita, Takayuki Nagasawa, Hiroshi Nishio, Jiro Suzuki, Shin Nishio, Hisanori Kobara, Mayu Yunokawa, Kazuya Ariyoshi, Takashi Hirayama, Hideki Tokunaga, Masayo Ukita, Kaori Yoriki, Mayuyo Mori‐Uchino, Akiko Furusawa, Shinichi Togami, Hiroko Nakamura, Mitsuya Ishikawa, Toyomi Satoh
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The outcome in patients with BRAF‐mutated metastatic melanoma treated with anti‐programmed death receptor‐1 monotherapy or targeted therapy in the real‐world setting Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Jindřich Kopecký, Marek Pásek, Radek Lakomý, Bohuslav Melichar, Ivona Mrazová, Ondřej Kubeček, Monika Arenbergerová, Radmila Lemstrová, Alžběta Švancarová, Vojtěch Tretera, Alžběta Hlodáková, Kamila Žváčková
BackgroundImmunotherapy and targeted therapy are currently two alternative backbones in the therapy of BRAF‐mutated malignant melanoma. However, predictive biomarkers that would help with treatment selection are lacking.MethodsThis retrospective study investigated outcomes of anti‐programmed death receptor‐1 monotherapy and targeted therapy in the first‐line setting in patients with metastatic BRAF‐mutated
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Effect of the SARS‐CoV‐2 pandemic on colorectal cancer diagnosis and prognosis Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Lucía Medina‐Prado, Noelia Sala‐Miquel, Marta Aicart‐Ramos, Julia López‐Cardona, Marta Ponce‐Romero, Oswaldo Ortíz, María Pellisé, Lara Aguilera, Pilar Díez‐Redondo, Henar Núñez‐Rodríguez, Agustín Seoane, María‐José Domper‐Arnal, Cristina Borao‐Laguna, Óscar González‐Bernardo, Adolfo Suárez, María Muñoz‐Tornero, Marco Bustamante‐Balén, Carlos Soutullo‐Castiñeiras, Belén Balleste‐Peris, Pilar Esteban
Background and Study AimsOur aim was to determine the impact of the SARS‐CoV‐2 pandemic on the diagnosis and prognosis of colorectal cancer (CRC).Patients and MethodsThis prospective cohort study included individuals diagnosed with CRC between March 13, 2019 and June 20, 2021 across 21 Spanish hospitals. Two time periods were compared: prepandemic (from March 13, 2019 to March 13, 2020) and pandemic
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Notch signaling genes and CD8+ T‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Kazuhiro Ogi, Takahiro Iwamoto, Takashi Sasaya, Koyo Nishiyama, Takaaki Tokura, Takanori Sasaki, Hironari Dehari, Yohei Arihara, Kazuyuki Murase, Masato Saito, Masanori Someya, Kohichi Takada, Akihiro Miyazaki
BackgroundAberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report the correlation between mutations in the Notch signaling pathway and CD8+ T‐cell infiltration via PD‐L1, which lead to enhanced antitumor immunity and may target for immune‐checkpoint inhibitors (ICIs) therapy.MethodsThis retrospective study analyzed the
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EXERT‐BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer Cancer Med. (IF 4.0) Pub Date : 2024-03-16 David J. Carpenter, Chris Peluso, Christie Hilton, Frank Velasquez, Adam Annichine, Krista Matsko, Jared Rosenberg, Alexander K. Diaz, Parker Hyde, Sushil Beriwal, Colin E. Champ
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Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Asma Manzari‐Tavakoli, Amirhesam Babajani, Maryam Manzari Tavakoli, Fahimeh Safaeinejad, Ameneh Jafari
Cancer remains a leading cause of death worldwide, necessitating the development of innovative and more effective treatment strategies. Conventional cancer treatments often suffer from limitations such as systemic toxicity, poor pharmacokinetics, and drug resistance. Recently, there has been growing attention to utilizing natural compounds derived from various sources as possible cancer therapeutics
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Reduced‐dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B‐cell acute lymphoblastic leukemia Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Jing Lu, Huifen Zhou, Xin Zhou, Yonggong Yang, Laigen Tong, Miao Miao, Xiaofei Yang, Suning Chen
BackgroundBlinatumomab early‐line treatment in B‐cell precursor acute lymphoblastic leukemia (B‐ALL) might improve clinical outcomes.MethodsWe conducted a retrospective real‐world cohort analysis in 20 newly diagnosed B‐ALL patients who received reduced‐dose chemotherapy (idarubicin, vindesine, and dexamethasone) for 1–3 weeks, followed by blinatumomab for 1–4 weeks as an induction therapy.ResultsAt
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Cardiovascular/anti‐inflammatory drugs repurposed for treating or preventing cancer: A systematic review and meta‐analysis of randomized trials Cancer Med. (IF 4.0) Pub Date : 2024-03-16 David J. Benjamin, Alyson Haslam, Vinay Prasad
BackgroundDue to encouraging pre‐clinical data and supportive observational studies, there has been growing interest in applying cardiovascular drugs (including aspirin, angiotensin‐converting enzyme [ACE] inhibitors, statins, and metformin) approved to treat diseases such as hypertension, hyperlipidemia, and diabetes mellitus to the field of oncology. Moreover, given growing costs with cancer care
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Construction and validation of machine learning models for predicting distant metastases in newly diagnosed colorectal cancer patients: A large‐scale and real‐world cohort study Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Ran Wei, Guanhua Yu, Xishan Wang, Zheng Jiang, Xu Guan
BackgroundMore accurate prediction of distant metastases (DM) in patients with colorectal cancer (CRC) would optimize individualized treatment and follow‐up strategies. Multiple prediction models based on machine learning have been developed to assess the likelihood of developing DM.MethodsClinicopathological features of patients with CRC were obtained from the National Cancer Center (NCC, China) and
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Novel metabolic biomarker for early detection and diagnosis to the patients with gastric cardia adenocarcinoma Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Meng Xia Wei, Zheng Yang, Pan Pan Wang, Xue Ke Zhao, Xin Song, Rui Hua Xu, Jing Feng Hu, Kan Zhong, Ling Ling Lei, Wen Li Han, Miao Miao Yang, Fu You Zhou, Xue Na Han, Zong Min Fan, Jia Li, Ran Wang, Bei Li, Li Dong Wang
BackgroundGastric cardia adenocarcinoma (GCA) is classified as Siewert type II adenocarcinoma at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% of diagnoses at an advanced stage, resulting in a grim prognosis, with less than a 20% 5‐year survival rate.MethodMetabolic features of 276 GCA and 588 healthy controls
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Deep learning‐based accurate diagnosis and quantitative evaluation of microvascular invasion in hepatocellular carcinoma on whole‐slide histopathology images Cancer Med. (IF 4.0) Pub Date : 2024-03-16 Xiuming Zhang, Xiaotian Yu, Wenjie Liang, Zhongliang Zhang, Shengxuming Zhang, Linjie Xu, Han Zhang, Zunlei Feng, Mingli Song, Jing Zhang, Shi Feng
BackgroundMicrovascular invasion (MVI) is an independent prognostic factor that is associated with early recurrence and poor survival after resection of hepatocellular carcinoma (HCC). However, the traditional pathology approach is relatively subjective, time‐consuming, and heterogeneous in the diagnosis of MVI. The aim of this study was to develop a deep‐learning model that could significantly improve
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A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3‐rearranged renal cell carcinoma Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Pengju Li, Quanhui Xu, Minyu Chen, Jiangquan Zhu, Yinghan Wang, Mukhtar A. Mumin, Kangbo Huang, Zeying Jiang, Hui Liang, Qiong Deng, Zhu Wang, Bing Liao, Wenfang Chen, Yun Cao, Jiazheng Cao, Junhang Luo
BackgroundTFE3 immunohistochemistry (TFE3‐IHC) is controversial in the diagnosis of TFE3‐rearranged renal cell carcinoma (TFE3‐rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3‐rearranged RCC.MethodsRetrospective analysis was performed by collecting IHC and fluorescence in situ hybridization (FISH) results from 228 patients
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Anatomic versus non‐anatomic liver resection for hepatocellular carcinoma—A European multicentre cohort study in cirrhotic and non‐cirrhotic patients Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Jasmin Zeindler, Gabriel Fridolin Hess, Maximilian von Heesen, Noa Aegerter, Cornelia Reber, Andreas Michael Schmitt, Simone Muenst, Martin Bolli, Savas Deniz Soysal, Otto Kollmar
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Urban relatives ameliorate survival disparities for genitourinary cancer in rural patients Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Mouneeb Choudry, Kassandra Dindinger‐Hill, Jacob Ambrose, Joshua Horns, Jeffrey Vehawn, Hailie Gill, Nicole Z. Murray, Trevor E. Hunt, Christopher Martin, Benjamin Haaland, Jonathan Chipman, Heidi A. Hanson, Brock B. O'Neil
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Efficacy and safety of atezolizumab plus bevacizumab in patients with portal hypertension for unresectable hepatocellular carcinoma Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Takahiro Kinami, Shinsuke Uchikawa, Tomokazu Kawaoka, Shintaro Yamasaki, Masanari Kosaka, Yusuke Johira, Shigeki Yano, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Masataka Tsuge, Shiro Oka
AimAtezolizumab plus bevacizumab combination therapy (Atezo + Beva) is used as the first‐line therapy for unresectable hepatocellular carcinoma (u‐HCC). Serious adverse events (AEs), including rupture of esophagogastric varices, have been seen during treatment. Therefore, the relationships of efficacy, safety, and portal hypertension (PH) were analyzed.MethodsA total of 146 patients with u‐HCC and
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Nomogram for predicting pathologic complete response to neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Guihong Liu, Tao Chen, Xin Zhang, Binbin Hu, Jiayun Yu
PurposeA pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) is seen in up to 40% of the patients with esophageal squamous cell carcinoma (ESCC). No nomogram has been constructed for the prediction of pCR for patients whose primary chemotherapy was a taxane‐based regimen. The aim is to identify characteristics associated with a pCR through analyzing multiple pre‐ and post‐nCRT
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Global burden, risk factors, and trends of non‐Hodgkin lymphoma: A worldwide analysis of cancer registries Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Junjie Huang, Sze Chai Chan, Veeleah Lok, Lin Zhang, Don Eliseo Lucero‐Prisno, Wanghong Xu, Zhi‐Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
BackgroundNon‐Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country.MethodsData from 185 countries globally were used for analysis. NHL incidence and mortality were collected via the GLOBOCAN (2020), CI5 series I‐X, WHO mortality database, the Nordic
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Brain metastases in patients with salivary duct carcinoma: A retrospective study Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Chihiro Fushimi, Hideaki Takahashi, Daisuke Kawakita, Satoshi Kano, Kiyoaki Tsukahara, Hiroyuki Ozawa, Kenji Okami, Akihiro Sakai, Keisuke Yamazaki, Takuro Okada, Toyoyuki Hanazawa, Yuichiro Sato, Yorihisa Imanishi, Akira Shimizu, Takashi Matsuki, Toshitaka Nagao, Yuichiro Tada
BackgroundSalivary duct carcinoma (SDC) is a high‐grade adenocarcinoma with a 5‐year survival rate of 40%. Although drug therapy has improved patients' prognosis, the impact of brain metastasis (BM) remains poorly understood. We aimed to retrospectively examine the incidence of BM in patients with SDC (n = 464) and develop a tool to estimate their prognoses.MethodsWe retrospectively examined 464 patients
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Significance of the cribriform morphology area ratio for biochemical recurrence in Gleason score 4 + 4 prostate cancer patients following robot‐assisted radical prostatectomy Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Kenji Shimodaira, Rie Inoue, Takeshi Hashimoto, Naoya Satake, Toshihide Shishido, Kazunori Namiki, Kazuharu Harada, Toshitaka Nagao, Yoshio Ohno
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Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis Cancer Med. (IF 4.0) Pub Date : 2024-03-13 So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
BackgroundClinical diabetic traits have been reported to be associated with increased colorectal cancer (CRC) risk in observational studies. Using the Mendelian randomization (MR) analysis method, we examined the causal association between glycemic traits, such as fasting glucose (FG), fasting insulin (FI), and glycosylated hemoglobin A1c (HbA1c), and survival in a cohort of CRC patients.MethodsWe
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Clinical value of endoscopic ultrasound sound speed in differential diagnosis of pancreatic solid lesion and prognosis of pancreatic cancer Cancer Med. (IF 4.0) Pub Date : 2024-03-13 Jianing Qiu, Kangrong Li, Xiuyan Long, Xiaoyu Yu, Pan Gong, Yu Long, Xiaoyan Wang, Li Tian
BackgroundDifferential diagnosis of pancreatic solid lesion (PSL) and prognosis of pancreatic cancer (PC) is a clinical challenge. We aimed to explore the differential diagnostic value of sound speed (SS) obtained from endoscopic ultrasonography (EUS) in PSL and the prognostic value of SS in PC.MethodsPatients with PSL in The Third Xiangya Hospital of Central South University from March 2019 to October
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Prediction of prognosis in oral squamous cell carcinoma using infrared microspectroscopy Cancer Med. (IF 4.0) Pub Date : 2024-03-12 Conor A. Whitley, Barnaby G. Ellis, Asterios Triantafyllou, Philip J. Gunning, Peter Gardner, Steve D. Barrett, Richard J. Shaw, Caroline I. Smith, Peter Weightman, Janet M. Risk
BackgroundEstimation of prognosis of oral squamous cell carcinoma (OSCC) is inaccurate prior to surgery, only being effected following subsequent pathological analysis of the primary tumour and excised lymph nodes. Consequently, a proportion of patients are overtreated, with an increase in morbidity, or undertreated, with inadequate margins and risk of recurrence. We hypothesise that it is possible
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Retraction: lncRNA ABHD11‐AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2 Cancer Med. (IF 4.0) Pub Date : 2024-03-12
Xiang‐Yang Zeng, Xiao‐Yan Jiang, Jia‐Hui Yong, Hui Xie, Jing Yuan, Da Zeng, Ying‐Yu Dou, Song‐Shu Xiao “lncRNA ABHD11‐AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2” Cancer Med. 2019; 8: 7074–7085 (https://doi.org/10.1002/cam4.2586)The above article, published online on 30 September 2019, in Wiley Online Library (wileyonlinelibrary
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Causal associations between atrial fibrillation and breast cancer: A bidirectional Mendelian randomization analysis Cancer Med. (IF 4.0) Pub Date : 2024-03-12 Zhaoting Gong, Mengjin Hu, Yuejin Yang, Chunlin Yin
BackgroundPrevious observational studies indicated that atrial fibrillation may increase the risk of breast cancer. Following a breast cancer diagnosis, the chance of developing atrial fibrillation may increase as well. However, it is uncertain whether the link is causal or just due to confounding factors.ObjectiveUsing bidirectional Mendelian randomization (MR) analysis, we sought to assess the bidirectional
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Combination tumor‐treating fields treatment for patients with metastatic non‐small cell lung cancer: A cost‐effectiveness analysis Cancer Med. (IF 4.0) Pub Date : 2024-03-12 Kun Liu, Youwen Zhu, Hong Zhu, Manting Zeng
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Lymph node metastases in middle and upper mediastinum of Siewert type II adenocarcinoma: A real‐world retrospective study Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Peng Luo, Xiankai Chen, Yafan Yang, Ruixiang Zhang, Xiaozheng Kang, Jianjun Qin, Xiuzhu Qi, Yin Li
ObjectiveTo explore whether the upper and/or middle mediastinal nodes (UMMN) should be dissected in Siewert type II adenocarcinoma (AC) according to the incidence of lymph node metastasis. Additionally, to investigate the association between the length of esophageal involvement (LEI) and the UMMN metastases.MethodsA cohort with Siewert type II AC who were operated on by a surgical team that routinely
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Virtual follow‐up care among breast and prostate cancer patients during and beyond the COVID‐19 pandemic: Association with distress Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Jacqueline L. Bender, Sarah Scruton, Geoff Wong, Nazek Abdelmutti, Alejandro Berlin, Julie Easley, Zhihui Amy Liu, Sharon McGee, Danielle Rodin, Jonathan Sussman, Robin Urquhart
BackgroundThe purpose of this study was to investigate associations between self‐reported distress (anxiety/depression) and satisfaction with and desire for virtual follow‐up (VFU) care among cancer patients during and beyond the COVID‐19 pandemic.MethodsBreast and prostate cancer patients receiving VFU at an urban cancer centre in Toronto, Canada completed an online survey on their sociodemographic
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High TPX2 expression results in poor prognosis, and Sp1 mediates the coupling of the CX3CR1/CXCL10 chemokine pathway to the PI3K/Akt pathway through targeted inhibition of TPX2 in endometrial cancer Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Mei Yang, Xiaogang Mao, Lin Li, Jiang Yang, Hui Xing, Chunfan Jiang
IntroductionApproximately 30% of individuals with advanced EC have unsatisfactory prognosis. Evidence suggests that TPX2 is frequently upregulated in malignancies and related to cancer progression. Its role and pathological mechanism in EC need further research.MethodsGSEA and TPX2 expression, GO, KEGG, and prognostic analyses were performed with TCGA data by bioinformatic approaches. Relationships
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Incidence of skeletal‐related events in patients with Ewing sarcoma: An observational retrospective study in Japan Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Hisaki Aiba, Yuki Kojima, Tatsunori Shimoi, Kazuki Sudo, Shu Yazaki, Toru Imai, Akihiko Yoshida, Shintaro Iwata, Eisuke Kobayashi, Akira Kawai, Ayumu Arakawa, Chitose Ogawa, Hiroaki Kimura, Kan Yonemori
BackgroundSkeletal‐related events (SREs), including the pathological fracture, surgical treatment or radiation of bone lesions, malignant spinal cord compression, hypercalcemia, are important considerations when managing metastatic bone tumors; however, owing to their rarity, the incidence of SREs in patients with Ewing sarcoma remains unknown.MethodsWe retrospectively reviewed the clinical data from
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Personal history of cancer as a risk factor for second primary lung cancer: Implications for lung cancer screening Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Sara Nofal, Jiangong Niu, Paul Resong, Jeff Jin, Kelly W. Merriman, Xiuning Le, Hormuzd Katki, John Heymach, Mara B. Antonoff, Edwin Ostrin, Jia Wu, Jianjun Zhang, Iakovos Toumazis
BackgroundPersonal history of cancer is an independent risk factor for lung cancer but is omitted from existing lung cancer screening eligibility criteria. In this study, we assess the lung cancer risk among cancer survivors and discuss potential implications for screening.MethodsThis was a retrospective, secondary analysis of data from the Surveillance, Epidemiology and End Results (SEER) registry
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Survival of the Hmong population diagnosed with colon and rectal cancers in the United States Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Margaret R. Walker, Kha Lor, Kajua B. Lor, Roberto J. Vidri, John M. Hampton, Cinthya Maldonado, Andrea M. Schiefelbein, Noelle K. LoConte
BackgroundThe Hmong population constitutes an independent ethnic group historically dispersed throughout Southeast Asia; fallout from the Vietnam War led to their forced migration to the United States as refugees. This study seeks to investigate characteristics of the Hmong population diagnosed with in colorectal cancer (CRC) as well as survival within this population.MethodsCases of colon and rectal
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TBCRC 057: Survey about willingness to participate in cancer clinical trials during the pandemic Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Karen Lisa Smith, Carolyn Mead‐Harvey, Gina L. Mazza, Eileen H. Shinn, Elizabeth S. Frank, Michelle E. Melisko, Cyd Eaton, Yisi Liu, Jeannine M. Salamone, Teri Pollastro, Patricia A. Spears, Nicole E. Caston, Antonio C. Wolff, Gabrielle Betty Rocque
BackgroundBreast cancer patients experienced heightened anxiety during the pandemic. Also, modifications to clinical trial activities allowing for virtual platforms, local assessments, and greater flexibility were introduced to facilitate participation. We sought to evaluate the association between pandemic‐related anxiety and willingness to participate in trials and how pandemic‐era modifications
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Psychometric validation of the Functional Assessment of Cancer Therapy‐Endometrial among endometrial cancer patients Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Sooyeon Kim, Joseph J. Noh, Youngha Kim, Juhee Cho, Danbee Kang, Yoo‐Young Lee
ObjectiveTo evaluate a psychometric validation of the endometrial cancer subscales (EnCS) in the Functional Assessment of Cancer Therapy‐Endometrial (FACT‐EN) among patients with endometrial cancer.MethodsThis cross‐sectional study was conducted at a tertiary university‐based hospital in South Korea between April and October 2022. Participants completed a survey questionnaire that included the FACT‐EN
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Comprehensive analysis indicated that NDE1 is a potential biomarker for pan‐cancer and promotes bladder cancer progression Cancer Med. (IF 4.0) Pub Date : 2024-03-11 Peihan Wang, Jinzhuo Ning, Wu Chen, Fan Zou, Weimin Yu, Ting Rao, Fan Cheng
BackgroundThe nuclear distribution E homologue 1 (NDE1) is a crucial dynein binding partner. The NDE1 protein has the potential to disrupt the normal functioning of centrosomes, leading to a compromised ability to generate spindles and ensure precise separation of chromosomes during cell division. The potential consequences of this phenomenon include genomic instability, malignant transformation and
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The generation of glioma organoids and the comparison of two culture methods Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Yang Zhang, Yunxiang Shao, Yanyan Li, Xuetao Li, Xuewen Zhang, Qinzhi E, Weichao Wang, Zuoyu Jiang, Wenjuan Gan, Yulun Huang
BackgroundThe intra‐ and inter‐tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres, and xenotransplantation models. The similarity between traditional tumor models and patients with glioma is very low.AimsIn this study, we aimed to address the limitations
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CaRE@ELLICSR: Effects of a clinically integrated, group‐based, multidimensional cancer rehabilitation program Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Christian J. Lopez, Daniel Santa Mina, Victoria Tan, Manjula Maganti, Cheryl Pritlove, Lori J. Bernstein, David M. Langelier, Eugene Chang, Jennifer M. Jones
BackgroundAlthough oncology clinical practice guidelines recognize the need and benefits of exercise, the implementation of these services into cancer care delivery remains limited. We developed and evaluated the impact of a clinically integrated 8‐week exercise and education program (CaRE@ELLICSR).MethodsWe conducted a mixed methods, prospective cohort study to examine the effects of the program.
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Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Yuan Feng, Zongpu Zhang, Fufang Qiu, Zixiao Yang, Ji Xiong, Wei Zhu, Fangzhu Wan, Bobin Chen, Jiguang Wang, Yi Zhang, Wei Hua
BackgroundIntracranial plasmacytomas are rare tumors arising from plasma cells with approximately half of the cases progressing to multiple myeloma (MM). However, there is a lack of comprehensive clinical cohort analysis on the clinical and pathological features, progression, and outcomes of intracranial plasmacytomas.MethodsA retrospective analysis of 190 cases was conducted, combining data from 38
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Prescribing pre‐ and post‐operative physical activity interventions for people undergoing breast cancer surgery: A qualitative systematic review Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Lauren Howe, Andy Husband, Anna Robinson‐Barella
IntroductionUndertaking physical activity, pre‐ and post‐operatively, can benefit recovery time and improve post‐surgical outcomes. One cohort of patients that have reported these benefits are those undergoing surgery for breast cancer. Yet, what remains unclear is the level to which physical activity interventions are implemented into standard surgical care for patients with breast cancer.AimsThis
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Relationship between fear of progression and symptom burden, disease factors and social/family factors in patients with stage‐IV breast cancer in Shandong, China Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Qianrun Lu, Qiuyue Liu, Shu Fang, Yujin Ma, Baoxuan Zhang, Huihui Li, Lihua Song
ObjectiveTo assess fear of progression (FoP)'s relationship with symptom burden and disease and social/family factors, as well as, determine the status of FoP in women with stage‐IV breast cancer in Shandong, China.MethodsTwo hundred and sixteen women were recruited from the department of breast cancer internal medicine, Shandong Cancer Hospital and Institute. Data for this observational study were
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Eliminating Medicaid dental benefits and early‐stage oral cancer diagnoses Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Jason Semprini, Julie Reynolds, Whitney E. Zahnd, George Wehby
BackgroundDespite the importance of regular dental visits for detecting oral cancer, millions of low‐income adults lack access to dental services. In July 2009, California eliminated adult Medicaid dental benefits. We tested if this impacted oral cancer detection for Medicaid enrollees.MethodsWe analyzed Surveillance, Epidemiology, and End Results‐Medicaid data, which contains verified Medicaid enrollment
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Impact of measurable residual disease in combination with CD19 on postremission therapy choices for adult t(8;21) acute myeloid leukemia in first complete remission Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Xi Jia, Naying Liao, Sijian Yu, Huan Li, Hui Liu, Haiyan Zhang, Jun Xu, Yunqian Yao, Han He, Guopan Yu, Qifa Liu, Yu Zhang, Pengcheng Shi
BackgroundThe post‐remission therapy (PRT) choices for adult t(8;21) acute myeloid leukemia (AML) in first complete remission (CR1) need to be further explored.AimsWe aimed to investigate the impact of measurable residual disease (MRD) combined with CD19 on PRT choices for adult t(8;21) AML in CR1.MethodsA total of 150 t(8;21) AML patients were enrolled, including 67 underwent chemotherapy (CMT) and
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Cell fusion between tumor cells and macrophages promotes the metastasis of OSCC patient through the activation of the chemokine signaling pathway Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Chengwan Xia, Qian Zhang, Yumei Pu, Qingang Hu, Yuxin Wang
BackgroundTumor metastasis is responsible for the high mortality rate of patients with oral squamous cell carcinoma (OSCC). Although many hypotheses have been proposed to elucidate the mechanism of tumor metastasis, the origin of the metastatic tumor cells remains unclear. In this study, we explored the role of cell fusion in the formation of OSCC metastatic tumor cells.MethodsMurine OSCC tumor cells
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Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Lourdes Guerrios‐Rivera, Jessica L. Janes, Amanda M. De Hoedt, Zachary Klaassen, Martha K. Terris, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, William J. Aronson, Jay H. Fowke, Stephen J. Freedland
BackgroundWe previously reported that outcomes after radical prostatectomy (RP) were similar among non‐Hispanic Black, non‐Hispanic White, and Hispanic White Veterans Affairs (VA) patients. However, prostate cancer (PC) mortality in Puerto Rican Hispanics (PRH) may be higher than in other Hispanic groups. Data focused on PRH patients is sparse; thus, we tested the association between PR ethnicity and
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Early recurrence, time‐to‐recurrence, and recurrence patterns: Assessing their impact on survival outcomes in head and neck squamous cell carcinoma (R/M‐HNSCC) patients treated with first line platinum‐based chemotherapy Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Pasvich Pitakpaiboonkul, Chuleeporn Jiarpinitnun, Poompis Pattaranutaporn, Nuttapong Ngamphaiboon
BackgroundR/M‐HNSCC patients typically receive 1L platinum‐based chemotherapy with pembrolizumab or cetuximab. However, the outcomes for patients with early recurrence (<6 months) remain unclear due to their exclusion from most 1L studies. This study aimed to assess the impact of time‐to‐recurrence intervals (TTRI) and recurrence patterns on the survival of R/M‐HNSCC patients.MethodsWe identified non‐curable
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A single‐centre, real‐world study of BTK inhibitors for the initial treatment of MYD88mut/CD79Bmut diffuse large B‐cell lymphoma Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Ting Deng, Shiyuan Zhang, Min Xiao, Jia Gu, Liang Huang, Xiaoxi Zhou
BackgroundMCD (MYD88L265P/CD79Bmut) diffuse large B‐cell lymphoma has a poor prognosis. There is no published clinical research conclusion regarding zanubrutinib or orelabrutinib for the initial treatment of MCD DLBCL.AimsThis study aimed to analyse the efficacy and safety of Bruton's tyrosine kinase inhibitor (BTKi) (zanubrutinib or orelabrutinib) therapy for newly diagnosed DLBCL patients with MYD88mut
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Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Mengli Zi, Yubo Ma, Jinxia Chen, Chuhong Pang, Xiao Li, Li Yuan, Zhuo Liu, Pengfei Yu
ObjectiveThis study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs).MethodsA retrospective enrollment of 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 and December 31, 2021. The study compared essential clinicopathological features and survival rates. Additionally
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Quercetin‐induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Chunlong Huang, Weihua Lai, Shuai Mao, Deli Song, Jihong Zhang, Xiao Xiao
BackgroundTumor metastasis and recurrence are major causes of mortality in patients with hepatocellular carcinoma (HCC) that is still lack of effective therapeutic targets and drugs. Previous reports implied that ras homolog family member C (RhoC) plays a toxic role on metastasis and proliferation of cancer.MethodsIn this research, the correlation between RhoC and metastasis ability was confirmed by
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Impact of inflammation and the immune system on hepatocellular carcinoma recurrence after hepatectomy Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Sha She, Jinzhi Shi, Jiling Zhu, Fan Yang, Jia Yu, Kai Dai
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide. Hepatectomy remains the first‐line treatment for patients with resectable HCC. However, the reported recurrence rate of HCC at 5 years after surgery is between 50% and 70%. Tumor‐related factors, including tumor size, number and differentiation, and underlying liver disease are well‐known risk factors for
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East Asian patients who received immunotherapy‐based therapy associated with improved survival benefit in advanced non‐small cell lung cancer: An updated meta‐analysis Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Yueyuan Yao, Butuo Li, Yiyue Xu, Linlin Yang, Bing Zou, Linlin Wang
BackgroundImmune checkpoint inhibitors (ICIs) combined with chemotherapy have been recommended as the standard treatment for advanced NSCLC patients without driver‐gene mutations. However, there are different genetic characteristics and biological traits of tumors between non‐East Asian (nEA) and East Asian (EA) patients with NSCLC, which may contribute to differences in the efficacy of ICIs in different
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Perceiving a need for dietary change in adults living with and beyond cancer: A cross‐sectional study Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Susan Smith, Abi Fisher, Phillippa J. Lally, Helen A. Croker, Anna Roberts, Rana E. Conway, Rebecca J. Beeken
BackgroundMany people living with and beyond cancer (LWBC) do not meet dietary recommendations. To implement a healthier diet, people LWBC must perceive a need to improve their diet.MethodsParticipants included people diagnosed with breast, prostate or colorectal cancer in the UK. Two binary logistic regression models were conducted with perceived need for dietary change as the outcome (need to improve
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An automatic parathyroid recognition and segmentation model based on deep learning of near‐infrared autofluorescence imaging Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Fan Yu, Tian Sang, Jie Kang, Xianzhao Deng, Bomin Guo, Hangzhou Yang, Xiaoyi Chen, Youben Fan, Xuehai Ding, Bo Wu
IntroductionNear‐infrared autofluorescence imaging (NIFI) can be used to identify parathyroid gland (PG) during surgery. The purpose of the study is to establish a new model, help surgeons better identify, and protect PGs.MethodsFive hundred and twenty three NIFI images were selected. The PGs were recorded by NIFI and marked with artificial intelligence (AI) model. The recognition rate for PGs was
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Mannitol versus furosemide in patients with thoracic malignancies who received cisplatin‐based chemotherapy using short hydration: A randomized phase II trial Cancer Med. (IF 4.0) Pub Date : 2024-03-08 Eriko Murakami, Hiroaki Akamatsu, Shunsuke Teraoka, Toshiaki Takakura, Eri Takase, Masanori Tanaka, Takahiro Kaki, Yuhei Harutani, Katsuyuki Furuta, Takeya Sugimoto, Ryota Shibaki, Daichi Fujimoto, Atsushi Hayata, Yuichi Ozawa, Masanori Nakanishi, Yasuhiro Koh, Toshio Shimokawa, Nobuyuki Yamamoto
BackgroundMannitol is exclusively recommended in the National Comprehensive Cancer Network guidelines for diuresis in cisplatin (CDDP)‐based chemotherapy. The utility of furosemide, a widely used and convenient diuretic, thus requires clarification.MethodsThis is a prospective, single‐centered, open‐label, noninferiority phase II study. Patients with thoracic malignancies who planned to receive CDDP‐based