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Carboxymethyl-sagocellulose-stabilized Fe3O4 nanoparticles with 5-fluorouracil as photothermal agents for tumor ablation Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-03-16 Anand Kumar Veeramachineni, Thenapakiam Sathasivam, Ragul Paramasivam, Saravanan Muniyandy, Shafii Bin Khamis, Yau Yan Lim, Janarthanan Pushpamalar
There is a continuous growth of interest in the development of nano-drug delivery systems that could combine therapy and diagnosis of cancer. Novel multifunctional superparamagnetic iron oxide nanoparticles (SPIONs, chemically Fe3O4) conjugated with carboxymethyl sagocellulose (CMSC), and 5-fluorouracil (Fe3O4-CMSC-5FU) were synthesized. The conjugated nanoparticles have the magnetic properties of
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Antitumor efficiency and photostability of newly green synthesized silver/graphene oxide nanocomposite on different cancer cell lines Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-03-09 Amna H. Faid, M. Abdel Rafea, Sara Gad, Marwa Sharaky, Marwa A. Ramadan
It is crucial to enhance new compounds for the treatment of most malignancies, and graphene oxide/silver nanocomposite (GO/Ag NC) has been paying attention to biomedical applications such as malignancies. In this work, green synthesized Ag@Cht NPs were successfully produced using chitosan for reduction and stabilization and added on GO sheet forming novel GO/Ag NC. Then, the produced anticancer nanomaterials
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Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-02-26 Jamal Moideen Muthu Mohamed, Fazil Ahmad, Mohamed El-Sherbiny, Mohammed Ahmad Al Mohaini, Krishnaraju Venkatesan, Yahya Bin Abdullah Alrashdi, Mamdouh Basheir Eldesoqui, Adel Ehab Ibrahim, Amal Fahmy Dawood, Ateya Megahed Ibrahim, Sami El Deeb
Colorectal cancer (CRC) is a type of cancer that affects the colon or rectum and occurs in individuals over the age of 50, although it can affect people of all ages. Quercetin is a flavonoid, which is a type of plant pigment with antioxidant and anti-inflammatory properties. Some studies have explored the potential of quercetin as an adjuvant therapy to enhance the effectiveness of chemotherapy or
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HepG2 exosomes coated luteolin nanoparticles remodeling hepatic stellate cells and combination with sorafenib for the treatment of hepatocellular carcinoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-02-22 Shengjie Ye, Xier Pan, Linghui Zou, Shuting Ni, Lei Zhang, Yanlong Hong, Kaili Hu
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and recurrence rate. The efficacy of the first-line drug sorafenib is impeded by drug resistance, which is closely related to activated hepatic stellate cells (HSCs). The natural product luteolin is good at alleviating the activation of HSC. However, its clinical application is limited to poor solubility, bioavailability
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Folic acid-functionalized PEGylated niosomes co-encapsulated cisplatin and doxoribicin exhibit enhanced anticancer efficacy Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-02-13 Mona Safari Sharafshadeh, Farzaneh Tafvizi, Parvin Khodarahmi, Somayeh Ehtesham
The medical field is faced with the difficult task of developing a new approach to curing cancer, which is prevalent in organs such as the breast and ovaries and has a high mortality rate. Since chemotherapy is the conventional method of treatment, efforts are being made to improve it to help patients function better. Fortunately, with the use of nanocarriers and their remarkable ability to manage
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Investigation of mitochondria-dependent apoptosis pathway and lipid peroxidation level induced by biosynthesized silver nanoparticles: caspase-3 activation, BAK1/BCLx regulation and malondialdehyde production Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-02-08 Haiwei Xiong, Xiaoyan Nie, Wei Cao, Jia Zhu, Jian Chen, Ruihao Liu, Yingliang Li
Nowadays, silver nanoparticles (AgNPs) have attracted the attention of many researchers due to their special physical, chemical, and biological properties. There is strong evidence that biogenic AgNPs can act as potent anticancer agents through the production of reactive oxygen species (ROS) and initiate the mitochondrial pathway of apoptosis. That is why we decided to use Nepeta bracteata Benth flower
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Opportunities and challenges of indocyanine green in gastrointestinal cancers for intraoperative and nano-medicine application Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-02-07 Liting Sun, Cong Meng, Zhongtao Zhang, Yao Luo, Zhengyang Yang, Hongwei Yao
The morbidity and mortality of gastrointestinal tumours remain high worldwide. Surgical resection is currently the most critical radical therapeutic schedule, while postoperative complications and sentinel lymph node (SLN) identification are closely related to the outcome. Indocyanine green (ICG)-mediated fluorescence imaging is increasingly being used in gastrointestinal surgery. It has been embraced
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The effect of doxorubicin curcumin co-loaded lipid nanoparticles and doxorubicin on osteosarcoma before surgery Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-31 Xinyan Lu, Peng Zhang, Jun Li, Yi Zhou, Bangjun Wang, Zhaoli Lu
The research aims to observe the difference in the effect of preoperative doxorubicin curcumin co-loaded lipid nanoparticles (DOX+CUR LPNs) and doxorubicin (VAD) in the treatment of osteosarcoma. 68 patients with osteosarcoma who visited the hospital from January 2020 to December 2022 are chosen. They are separated into VAD group and DOX+CUR LPNs group, with 34 cases in each group. VAD and DOX+CUR
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Polymer lipid hybrid nanoparticles encapsulated with Emodin combined with DOX reverse multidrug resistance of breast cancer via IL-6/JAK2/STAT3 signaling pathway Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-31 Honghui Gu, Fansu Meng, Haidong Sun, Lina Yang, Qi Li, Zhong Chen, Tiange Cai, Zhenjiang Yang, Yu Cai
Multidrug resistance (MDR) is one of the main reasons affecting the efficacy of chemotherapy in breast cancer (BC). Our previous studies constructed polymer lipid hybrid nanoparticles encapsulated with Emodin (EMO) (E-PLNs) and proved that they can inhibit epithelial mesenchymal transition (EMT) and reverse MDR in BC. This study aims to explore the mechanisms by which the EMT involved in MDR and the
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Mesoporous silica nanotechnology: promising advances in augmenting cancer theranostics Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-31 Yashaswi Dutta Gupta, Yuri Mackeyev, Sunil Krishnan, Suman Bhandary
Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired as a worthwhile platform for cancer theranostics over the last decade. The full potential of MSNs in cancer theranostics, however, is yet to be realized. While MSNs can be employed for targeted drug delivery and imaging, their effectiveness
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Novel nanoparticle CS-C60-Fe3O4 magnetically induces tissue-specific aggregation and enhances thermal ablation of hepatocellular carcinoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-23 Jie Sun, Zhengyao Chang, Xudong Gao, Huiwei Sun, Yantao Chai, Xiaojuan Li, Xiaoming Zhang, Fan Feng
Metallofullerenes are an important type of metallic nanomaterial with promising applications in several medical fields. Thermal ablation, including radiofrequency ablation (RFA) and microwave ablation (MWA), is an important treatment strategy for advanced hepatocellular carcinoma (HCC). The thermal expansion of fullerenes makes them good adjuncts to thermal ablation treatment of HCC. In this study
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Designing nanostructured lipid carriers modified with folate-conjugated chitosan for targeted delivery of osthole to HT-29 colon cancer cells: investigation of anticancer, antioxidant, and antibacterial activities Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-23 Ghazal Hosseini Torshizi, Masoud Homayouni Tabrizi, Ehsan Karimi, Atefeh Younesi, Zahra Larian
The present study proposed to design nanostructured lipid carriers (NLC) coated with chitosan (CS) conjugated folate (FA) for the targeted delivery of Osthole (OST) to the HT-29 colon cancer cell line and improve its anticancer capability. To assess the physicochemical characteristics of OST-loaded NLC decorated with CS-conjugated FA (OST-NCF-NPS), several techniques, including DLS, SEM, and FTIR,
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Dual-targeting nanomedicine achieves synergistic multimodal therapy for tumor Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-13 Weidong Zhang, Liang Dai, Na Wang, Yunhe Liu, Zining Hao, Yaqian He, Song Ni, Yimin Wang, Dawei Gao
The poor targeting delivery efficiency and limited efficacy of single therapeutic approach have consistently posed significant challenges in tumor management. In this research, we have conceived and synthesized a dual-targeting nanodrug delivery system denoted as PDA-DEM-Fe3O4@M, which incorporates a polydopamine nanoparticle (PDA) with photothermal properties, diethyl maleate (DEM) as a chemotherapy
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Anticancer platinum-drug delivered by mesenchymal stromal cells improves its activity on glioblastoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-10 Valentina Coccè, Eleonora Martegani, Luisa Doneda, Isabella Rimoldi, Giorgio Facchetti, Coffetti Giulia, Giorgio Lucchini, Leda Roncoroni, Aldo Giannì, Costantino Corradini, Giulio Alessandri, Emilio Ciusani, Francesco Cilurzo, Silvia Franzè, Francesca Paino, Augusto Pessina
Glioblastoma multiforme (GBM) is nowadays the most aggressive tumor affecting brain in adults with a very poor prognosis due to the limited therapies and the systemic cytotoxicity. Among the different new drugs, recently has been reported the in vitro anti-glioma activity of a new cationic platinum(II) complex bearing 8-aminoquinoline as chelating ligand (Pt-8AQ). The purpose of this research work
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SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-06 Lihui Si, Shuli Yang, Ruixin Lin, Shiyu Gu, Chuhan Yan, Jia Yan
Ovarian cancer treatment is challenged by resistance and off-target effects. Melittin shows promise against cancer but is limited by its instability and harmful cellular interactions. Our study introduces SiO2–alginate–melittin nano-conjugates (SAMNs), incorporating alginate lyase to enhance melittin's release and mitigate alginate drawbacks. We combined melittin with alginate and mesoporous silica
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Novel nanotherapeutics for cancer immunotherapy by albumin nanoparticles functionalized with PD-1 and PD-L1 aptamers Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-06 Qiping Jiang, Fengjiao Yao, Yacong An, Xialian Lai, Xundou Li, Zhen Yu, Xian-Da Yang
PD-1/PD-L1 blockade plays a crucial role in cancer immunotherapy. Exploration of new technologies to further enhance the efficacy of PD-1/PD-L1 blockade is therefore of potential medical importance. Nanotherapeutics can accumulate in tumor tissues due to enhanced permeability and retention (EPR) effects. In this study, a novel nanotherapeutic for cancer immunotherapy was implemented with albumin nanoparticles
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Synthesis and characterization of silver nanoparticles loaded with carboplatin as a potential antimicrobial and cancer therapy Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-06 Tutku Tunç
In recent studies with silver nanoparticles, it has been reported that the use of nanoparticles in carrier drug systems increases tumor suppression and reduces drug-related side effects. At the same time, the combination of traditional medicine with nanotechnology provides the opportunity to develop new antimicrobial agents. The aim of this study was to determine the anticancer, antimicrobial activities
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Mesothelin-targeted MRI for assessing migration, invasion, and prognosis in malignant pleural mesothelioma Cancer Nanotechnol. (IF 5.7) Pub Date : 2024-01-05 Yilong Huang, Shasha Shen, Jie Xiao, Cici Luo, Jiyao Ma, Xin Huang, Tianfu Qi, Chao Gao, Guiyun Li, Fan Li, Bo He, Bingdi Chen, Dan Han
Mesothelin (MSLN) has been implicated in cancer migration, invasion, and prognosis, making it a potential tumor marker. However, the precise role of MSLN in the migration and invasion of malignant pleural mesothelioma (MPM) remains elusive, and effective noninvasive methods for assessing MSLN status are currently lacking. In this study, we focused on MSLN expression and elucidated the underlying mechanisms
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Publisher Correction: Green adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-11-30 Pramod C. Mane, Deepali D. Kadam, Ashok N. Khadse, Aditya R. Chaudhari, Supriya P. Ughade, Sachin B. Agawane, Ravindra D. Chaudhari
Publisher Correction: Cancer Nanotechnol (2023) 14:79 https://doi.org/10.1186/s12645-023-00226-2 The publisher regrets that the article was originally published without identifying Sachin Agawane as co-corresponding author of the article. This information has now been corrected through the correction article. The Original article (Mane et al. 2023) has now been corrected. Mane PC, Kadam DD, Khadse
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CD44-specific short peptide A6 boosts cellular uptake and anticancer efficacy of PEGylated liposomal doxorubicin in vitro and in vivo Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-11-23 Rezvan Yazdian-Robati, Ehsan Amiri, Hossein Kamali, Aysun Khosravi, Seyed Mohammad Taghdisi, Mahmoud Reza Jaafari, Mohammad Mashreghi, Seyedeh Alia Moosavian
Although liposomes have improved patient safety and the pharmacokinetic profile of free drugs, their therapeutic efficacy has only shown marginal improvement. The incorporation of active-targeted ligands to enhance cellular uptake has shown promise in preclinical studies. However, no active-targeted liposomes have successfully translated into clinical use thus far. This study aimed to evaluate the
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Enhanced cancer immunotherapy through synergistic ferroptosis and immune checkpoint blockade using cell membrane-coated nanoparticles Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-11-13 Yeteng Mu, Yuxin Fan, Lianping He, Nannan Hu, Han Xue, Xingang Guan, Zhijian Zheng
Immune checkpoint blockade (ICB) has achieved unprecedented success in inhibiting the progression and metastasis of many cancers. However, ICB regents as a single treatment have a relatively low overall response rate due to the tumor’s low immunogenicity and immunosuppressive microenvironment. Herein, we report a PD-1 cellular membrane-coated ferroptosis nanoinducer to potentiate cancer immunotherapy
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Application of tumor microparticles in tumor prevention and treatment Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-11-01 Weiwei Sun, Pingwei Xu, Pengtao Pan, Sheng Guo, Rui Liu, Guojie Ji, Huanhuan Hu, Weidong Li, Lili Dai
Tumor microparticles (T-MPs) are vesicles released from tumor cells when they receive apoptotic or stimuli signals. T-MPs, which contain some proteins, lipids and nucleic acids from tumor cells, contribute to the exchange of material, energy and information between cells. T-MPs contain both tumor antigens and innate immunostimulatory signals, making T-MPs as a new form of tumor vaccine. Meanwhile,
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Induction of ferroptosis by artesunate nanoparticles is an effective therapeutic strategy for hepatocellular carcinoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-21 Dengyun Nie, Ting Guo, Xinyu Zong, Wenya Li, Yinxing Zhu, Miao Yue, Min Sha, Mei Lin
Artesunate (ART) has great value in the field of tumor therapy. Interestingly, in this study, we found that ART could obviously induce ferroptosis in hepatocellular carcinoma (HCC) cells, but its low water solubility and bioavailability limited its application potential. Hence, we synthesized ART-loaded mesoporous silica nanoparticles (MSNs) conjugated with folic acid (FA) (MSN-ART-FA) with tumor-targeting
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Utilizing two-dimensional monolayer and three-dimensional spheroids to enhance radiotherapeutic potential by combining gold nanoparticles and docetaxel Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-19 Kyle Bromma, Wayne Beckham, Devika B. Chithrani
Much in vitro research on the applicability of gold nanoparticles (GNPs) in cancer treatment has been focused on two-dimensional (2D) monolayer models. To improve this, we explored the effect of the combination of GNPs and docetaxel (DTX) with radiotherapy (RT) in a more complex three-dimensional (3D) spheroid that can better mimic a real tumour microenvironment. Two cell lines, prostate cancer LNCaP
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Green adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-16 Pramod C. Mane, Deepali D. Kadam, Ashok N. Khadse, Aditya R. Chaudhari, Supriya P. Ughade, Sachin B. Agawane, Ravindra D. Chaudhari
In the present era, we are facing different health problems mainly concerning with drug resistance in microorganisms as well as in cancer cells. In addition, we are also facing the problems of controlling oxidative stress and insect originated diseases like dengue, malaria, chikungunya, etc. originated from mosquitoes. In this investigation, we unfurled the potential of Achatina fulica mucus in green
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Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20) Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-06 Huei-Jen Chen, Yi-An Cheng, Yu-Tung Chen, Chia-Ching Li, Bo-Cheng Huang, Shih-Ting Hong, I.-Ju Chen, Kai-Wen Ho, Chiao-Yun Chen, Fang-Ming Chen, Jaw-Yuan Wang, Steve R. Roffler, Tian-Lu Cheng, Dung-Ho Wu
PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma and actively internalize into cancer cells to enhance therapeutic efficacy. We generated an anti-PEG bispecific antibody (BsAb; mPEG × CD20) which was able to simultaneously bind to methoxy PEG
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Based polymer nanoparticles from bee pollen attenuate non-small lung cancer through enhancement of apoptosis and cell cycle arrest in vivo Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-06 Elsayed I. Salim, Magdy E. Mahfouz, Eman A. Eltonouby, Nemany A. N. Hanafy, Ezar H. Hafez
Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are: Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). After the BHT injection, the mice in Groups 3, 4, 5,
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Boosting nuclear-targeted photothermal-chemotherapy by NIR-responsive hybrid membrane camouflaged nanotherapeutics Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-10-03 Xinyue Xing, Yuying Zeng, Wanqing Zhong, Wendai Cheng, Chengxin Zhou, Xiaoxu Lu, Liyun Zhong
Engineering nanotherapeutics have been extensively studied for cancer therapy. However, the therapeutic efficacy is still severely restricted by biophysiological barriers and intracellular accumulation. Although the biomimetic nanoparticles have improved the former issue, there is almost no breakthrough in researches of intracellular transport. Herein, we proposed a NIR-responsive nuclear-targeted
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Dual enhancement in the radiosensitivity of prostate cancer through nanoparticles and chemotherapeutics Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-09-29 Nolan Jackson, Iona Hill, Abdulaziz Alhussan, Kyle Bromma, Jessica Morgan, Belal Abousaida, Yasmin Zahra, Yuri Mackeyev, Wayne Beckham, Steven Herchko, Sunil Krishnan, Devika Basnagge Chithrani
Radiotherapy (RT) is an essential component in the treatment regimens for many cancer patients. However, the dose escalation required to improve curative results is hindered due to the normal tissue toxicity that is induced. The introduction of radiosensitizers to RT treatment is an avenue that is currently being explored to overcome this issue. By introducing radiosensitizers into tumor sites, it
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Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-09-07 Camila Sales Nascimento, Naiara Clemente Tavares, Izabella Cristina Andrade Batista, Mônica Maria Magalhães Caetano, Eneida Santos de Oliveira, Stella Garcia Colombarolli, Anna Carolina Pinheiro Lage, Rodrigo Corrêa-Oliveira, Érica Alessandra Rocha Alves, Celso Pinto de Melo, Carlos Eduardo Calzavara-Silva
Breast cancer is the neoplastic disease with the highest incidence and mortality in the female population worldwide. Treatment remains challenging due to various factors. Therefore, it is of great importance to develop new therapeutic strategies that promote the safe destruction of neoplastic cells without compromising patients' quality of life. Among advances in the treatment of breast cancer, immunotherapy
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ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-09-04 Ashique Al Hoque, Debasmita Dutta, Brahamacharry Paul, Leena Kumari, Iman Ehsan, Moumita Dhara, Biswajit Mukherjee, Mohiuddin Quadir, Benny Abraham Kaipparettu, Soumik Laha, Shantanu Ganguly
Prostate cancer (PCa) is one of the fatal illnesses among males globally. PCa-treatment does not include radiotherapy. Chemotherapy eventually causes drug resistance, disease recurrence, metastatic advancement, multi-organ failure, and death. Preclinical data on PCa-induced by carcinogens are truly scarce. Although some data on xenograft-PCa in animals are available, they mostly belonged to immuno-compromised
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A ‘golden’ alternative for prevention of cisplatin nephrotoxicity in bladder cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-09-01 Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, Eli Rosenbaum
Cisplatin (CP) is the first-line standard of care for bladder cancer. However, a significant percentage of advanced bladder cancer patients are ineligible to receive standard CP treatment, due to the drug’s toxicity, and in particular its nephrotoxicity. These patients currently face suboptimal therapeutic options with lower efficacy. To overcome this limitation, here we designed CP-conjugated gold
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Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-08-12 Kousain Kousar, Faiza Naseer, Maisa S. Abduh, Sadia Anjum, Tahir Ahmad
Newcastle disease virus (NDV) Lasota strain has proven oncolytic activity. One shortcoming associated with this treatment modality is the immune neutralization of the virus in body, mediated by natural killer cells and macrophages. This study aims at encapsulating the oncolytic virus in thiolated chitosan nanoparticles, surface functionalized with hyaluronic acid for CD44 targeted delivery and sustained
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Cabazitaxel-loaded human serum albumin nanoparticles combined with TGFβ-1 siRNA lipid nanoparticles for the treatment of paclitaxel-resistant non-small cell lung cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-07-29 Tiantian Tan, Yuxin Feng, Weimin Wang, Rongrong Wang, Liyan Yin, Yiying Zeng, Zhaowu Zeng, Tian Xie
In the current treatment of non-small cell lung cancer (NSCLC), traditional chemotherapy causes high toxicity, so it is necessary to develop safe chemical drug delivery vehicles clinically. Chemotherapy monotherapy is prone to drug resistance. Chemotherapy combined with other therapies such as nucleic acid drugs is an effective way to avoid drug resistance and the toxicity of continuous chemotherapy
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Investigating the anticancer and anti-angiogenic effects of graphene oxide nanoparticles containing 6-gingerol modified with chitosan and folate Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-07-25 Angham Hakim Abdulzahra Al-Janabi, Nasim Hayati Roodbari, Masoud Homayouni Tabrizi
The use of nanocarriers to improve the targeting of treatment plays a key role in the treatment of many diseases, including cancer. This study was carried out to synthesize graphene oxide (GO) containing 6-gingerol (Ging) modified with chitosan (CS)-folic acid (FA) nanoparticles (Ging-GO-CS-FA) to improve the anti-cancer effects of Ging. After the synthesis of nanoparticles, the average size, surface
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Correction: Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-07-06 Faiza Naseer, Kousain Kousar, Maisa S. Abduh, Sadia Anjum, Tahir Ahmad
Correction: Cancer Nanotechnology (2023) 14:65 https://doi.org/10.1186/s12645-023-00218-2 Following publication of the original article (Naseer et al. 2023), the below Acknowledgement was missing. Acknowledgement We gratefully acknowledge the technical and financial support of the Deanship of Scientific Research (DSR) provided at King Abdulaziz University, Jeddah, Saudi Arabia under Grant No. (FP-225-43)
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Mesoporous silica nanoparticles boost aggressive cancer response to hydrophilic chlorin e6-mediated photodynamic therapy Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-07-01 Sara A. Abdel Gaber, Herbert Stepp, Mahmoud H. Abdel Kader, Mika Lindén
Chlorin e6 trisodium salt (Ce6) is a newly developed hydrophilic photosensitizer designed to mediate anticancer photodynamic therapy (PDT). The response of different cancer types and strategies to boost anticancer efficiency of Ce6-PDT are poorly studied. This study aimed to investigate the response of different cancer types to Ce6-PDT, identify the unresponsive ones, and develop a nanosystem for response
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Co-delivery of curcumin and si-STAT3 with a bioinspired tumor homing for polydopamine nanoparticles for synergistic osteosarcoma therapy Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-20 Kunzhe Wu, Zhongsheng Zhou, Te Liu, Chunkang Liu, Xupeng Mu, Jinlan Jiang
Owing to the complexity of cancer, a synergistic combination of chemotherapy and gene therapy can be a promising therapeutic strategy. This study aimed to use stem cell membrane (SCM)-camouflaged polydopamine nanoparticles for simultaneous delivery of curcumin (CUR) and siRNA-targeting STAT3 (CPDA/siSTAT3@SCM NPs) for osteosarcoma (OS). Transmission electron microscopy, UV–Vis absorbance spectra, zeta
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Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-20 Faiza Naseer, Kousain Kousar, Maisa S. Abduh, Sadia Anjum, Tahir Ahmad
The in vivo anticancer potential of vincristine (VC) loaded, thiolated chitosan-based nanoformulation (NFs) with an outer hyaluronic acid (VC-loaded in TCs-HA) coating was studied in prostate cancer (PC) xenograft in the immunosuppressed rat model induced by PC3 cell lines. Our previous study has already reported the in vitro efficacy of the said NFs. The ADMET Predictor (TM) Cloud version 10.4.0.5
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An electrostatically conjugated-functional MNK1 aptamer reverts the intrinsic antitumor effect of polyethyleneimine-coated iron oxide nanoparticles in vivo in a human triple-negative cancer xenograft Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-14 Vladimir Mulens-Arias, Yadileiny Portilla, Sonia Pérez-Yagüe, Raquel Ferreras-Martín, M. Elena Martín, Victor M. González, Domingo F. Barber
Triple-negative breast cancer (TNBC) remains a difficult breast cancer subtype to treat as it exhibits a particularly aggressive behavior. The dysregulation of distinct signaling pathways underlies this aggressive behavior, with an overactivation of MAP kinase interacting kinases (MNKs) promoting tumor cell behavior, and driving proliferation and migration. Therefore, MNK1 is an excellent target to
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Emerging applications of extracellular vesicles in tumor therapy Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-14 Hui Luo, Jing Jin, Jiajia Jin, Kecheng Lou, Hailan He, Shangzhi Feng, Fei Zeng, Junrong Zou
Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers. Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory
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Nanoliposomal VEGF-R2 peptide vaccine acts as an effective therapeutic vaccine in a murine B16F10 model of melanoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-14 Fatemeh Zahedipour, Parvin Zamani, Mohammad Mashreghi, Mojgan Astaneh, Mojtaba Sankian, Atefeh Amiri, Khadijeh Jamialahmadi, Mahmoud Reza Jaafari
The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in melanoma development and progression. Peptide vaccines have shown great potential in cancer immunotherapy by targeting VEGFR-2 as a tumor-associated antigen and boosting the immune response against both tumor cells and tumor endothelial cells. Despite this, the low efficiency of peptide vaccines has resulted in moderate
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Theranostic RGD@Fe3O4-Au/Gd NPs for the targeted radiotherapy and MR imaging of breast cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-14 Azadeh Amraee, Zahra Alamzadeh, Rasoul Irajirad, Abolfazl Sarikhani, Habib Ghaznavi, Hossein Ghadiri Harvani, Seied Rabi Mahdavi, Sakine Shirvalilou, Samideh Khoei
As a radiosensitizing agent in magnetic resonance imaging (MRI), gadolinium is disadvantageous in that it confers a rather high toxicity and low longitudinal comfort time (r1). We hypothesized that gadolinium when combined with gold-coated iron oxide nanoparticles (NPs), might deliver better radiosensitization in MRI-based cancer theranostics. After being synthesized ligand/receptor RGD@Fe3O4-Au/Gd
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Nickel-gallate metal–organic framework as an efficient antimicrobial and anticancer agent: in vitro study Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-09 Ahmed. A. G. El-Shahawy, Esam M. Dief, S. I. El-Dek, A. A. Farghali, Fatma I. Abo El-Ela
Gallic acid is a natural antioxidant present in many plants such as tea, sumac, gallnut and other plants. This naturally occurring gallic acid is known to exhibit auto-oxidation under certain conditions, generating several reactive oxygen species (ROS) including superoxides, hydroxyls and hydrogen peroxide radicals that plays key roles in its antimicrobial activity. Here, we demonstrate that incorporating
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HB5 aptamer-tagged graphene oxide for co-delivery of doxorubicin and silibinin, and highly effective combination therapy in breast cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-06-03 Maryamsadat Shahidi, Bibi Fatemeh Haghiralsadat, Omid Abazari, Mahdie Hemati, Parisa Dayati, Hossein Zarei Jaliani, Najmeh Sadat Hosseini Motlagh, Seyed Morteza Naghib, Ali Moradi
Using a chemotherapeutic agent, such as doxorubicin (DOX), with a natural agent, such as silibinin (Sili), is highly valuable to minimize systemic toxicity. However, Sili and DOX face disadvantages, such as low aqueous solubility and poor bioavailability. Here, we have engineered a drug delivery cargo by decorating carboxylated graphene oxide (cGO) with an aptamer, HB5, for simultaneous delivery of
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Advances in blood–brain barrier-crossing nanomedicine for anti-glioma Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-29 Dongdong Liu, Xingliang Dai, Zhenchao Tao, Hu Zhou, Wenqing Hong, Haisheng Qian, Hongwei Cheng, Xianwen Wang
Glioma is the most prevalent type of primary brain tumor, and glioblastoma multiforme (GBM) is the highest and most deadly type of primary central nervous system (CNS) tumor, affecting a significant number of patients each year, with a median overall survival of approximately 14.6 months after diagnosis. Despite intensive treatment, nearly all GBM patients experience recurrence, with a 5-year survival
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ADAMTS9-AS1 inhibits tumor growth and drug resistance in clear cell renal cell carcinoma via recruiting HuR to enhance ADAMTS9 mRNA stability Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-20 Enyang Zhao, Bo Geng, Ran Tao, Bosen You, Yunli Liu, Wenbin Hou, Wanhui Wang, Changlin Wang, Xuedong Li
The lack of efficacious treatments for clear cell renal cell carcinoma (ccRCC) has led to a poor 5-year survival rate. Here, we found that the expression of ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) antisense RNA 1 (ADAMTS9-AS1) is commonly decreased in ccRCC tissues. Decreased ADAMTS9-AS1 is associated with advanced stages and poor prognosis in ccRCC patients. Additionally
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Targeting and sensitizing MDR cancer by an MMP2 and pH dual-responsive ZnO-based nanomedicine Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-20 Qing Zhou, Li Zhang, Yujiao Li, Jiao Wang, Xiaolu He, Jieyu Zhang, Youbei Qiao, Hong Wu, Lin Zhu
Zinc oxide nanoparticles (ZnO NPs) have been known as a therapeutic agent and drug delivery system for treating various diseases, including infectious diseases and cancer. However, due to the low biocompatibility, short in vivo half-life, and potential toxicity, the previous studies on ZnO NPs were mainly focused on their in vitro applications. The effective and safe ZnO NP-based systems which can
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Early stage evaluation of cancer stem cells using platinum nanoparticles/CD133+ enhanced nanobiocomposite Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-20 Solmaz Sadi, Balal Khalilzadeh, Mahdi Mahdipour, Fatemeh Sokouti Nasimi, Ibrahim Isildak, Soodabeh Davaran, Mohammad-Reza Rashidi, Farhad Bani
Cancer stem cells (CSCs) are of great diagnostic importance due to their involvement in tumorigenesis, therapeutic resistance, metastasis and relapse. In this work, a sensitive electrochemical cytosensor was successfully established to detect HT-29 colorectal cancer stem cells based on a nanocomposite composed of mesoporous silica nanoparticles (MSNs) and platinum nanoparticles (PtNPs) using a simple
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Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-19 Rebekah Anamarie Gundersen, Tianyuan Chu, Kiana Abolfathi, Serap Gokcen Dogan, Phoebe Elizabeth Blair, Nyasha Nago, Michael Hamblin, Greg Nicholas Brooke, Ralf Michael Zwacka, Ali Kafash Hoshiar, Andrea Mohr
Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer. We found that human MSCs can be readily loaded with magnetic particles and that the resulting biohybrid microrobots could be guided by a rotating magnetic field. Rotating magnetic fields have the potential
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Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-16 Reju George Thomas, Subin Kim, Raveena Nagareddy, Veena Vijayan, Ansuja Mathew Pullickal, Mee Sun Yoon, In Kyu Park, Yong Yeon Jeong
Tumor hypoxia is an important factor for developing resistance to radiation therapy (RT) and presents a bleak prognosis in cancer patients undergoing treatment for RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn3O4 (MGN) nanoparticles (Lipo-MGN) and investigation of their therapeutic potential with RT utilizing a HepG2 cancer model. According to in vitro
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Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-12 Yue He, Hongtao Rao, JingJing Wang, Ying Wu, Caiqin Han, Changchun Yan, Hunter Temple, Le Zhang, Wei Chen, Ying Liu
The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2 + QDs based on the combination of rare
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Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-11 Wenwen Ji, Bei Zhang, Xuetong Sun, Lijuan Ma, Xiangying Zhang, Wenhui Qian, Wenjuan Fu, Jianting Li, Dong Zhu
Blocking the binding of PD-1/PD-L1 has become an effective strategy in inhibition of tumor immune escape. At present, it mainly depends on the employment of macromolecular antibodies, which target PD-1/PD-L1 protein through binding one of PD-1 or PD-L1 domains. In this study, we present a different strategy, an aptamer modified molecularly imprinted polymer layer (APD–PD-L1–MIPL), to break PD-1/PD-L1
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Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-09 Hongsheng Wang, Xinmeng Jin, Yinghua Gao, Xin He, Yiming Xu, Haoran Mu, Yafei Jiang, Zhuoying Wang, Chen Yu, Tao Zhang, Yingqi Hua, Zhengdong Cai, Jing Xu, Xiaojun Ma, Wei Sun
Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) and vascular aberrations in the TME. TME reprogramming is a promising therapeutic approach for treating tumors. Anti-angiogenesis has the power to control the polarization of macrophages, prevent
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Formulation and optimization of folate-bovine serum albumin-coated ethoniosomes of pterostilbene as a targeted drug delivery system for lung cancer: In vitro and in vivo demonstrations Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-08 Nemany A. N. Hanafy, Reham H. Abdelbadea, Abdelaziz E. Abdelaziz, Eman A. Mazyed
This study aimed to overcome the poor solubility of pterostilbene (PTS) by developing promising reconstituted proethoniosomes (PENs). The reconstituted PENs loaded with PTS were fabricated according to a 23 factorial design by Design-Expert® software. The prepared ethoniosomes were assessed for entrapment efficiency (EE %) and % PTS released after 24 h (Q24h). According to the desirability criteria
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Non-small cell lung cancer targeted nanoparticles with reduced side effects fabricated by flash nanoprecipitation Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-05 Mingwei Wang, Haiyan Huang, Zilong Zhong, Xinyue Chen, Yuan Fang, Shenxin Chen, Zhiyao Qi, Danrong Yang, Junyou Wang, Wei Bian
Tyrosine kinase inhibitors (TKI) have been highlighted for the therapy of non-small-cell lung cancer (NSCLC), due to their capability of efficiently blocking signal pathway of epidermal growth factor receptor (EGFR) which causes the inhibition and apoptosis of NSCLC cells. However, EGFR-TKIs have poor aqueous solubility and severe side effects arising from the difficulty in control of biodistribution
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Biological modeling of gadolinium-based nanoparticles radio-enhancement for kilovoltage photons: a Monte Carlo study Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-02 Jianan Wu, Xiaohan Xu, Ying Liang, Tujia Chen, Enzhuo Quan, Luhua Wang
Gadolinium-based nanoparticles (GdNPs) are clinically used agents to increase the radiosensitivity of tumor cells. However, studies on the mechanisms and biological modeling of GdNP radio-enhancement are still preliminary. This study aims to investigate the mechanism of radio-enhancement of GdNPs for kilovoltage photons using Monte Carlo (MC) simulations, and to establish local effect model (LEM)-based
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Investigation of hollow mesoporous NiFe2O4 nanospheres fabricated via a template-free solvothermal route as pH-responsive drug delivery system for potential anticancer application Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-05-02 Qing Qi, Hui Zhang, Mengru Liu, Shujing Qi, Zhongchao Huo, Yingying Ma, Zhongqiang Zhang, Yongchang Lu, Xiongwei Qi, Shuai Han, Guangshuo Wang
A novel magnetic-targeted pH-responsive intelligent drug carrier based on hollow mesoporous structured NiFe2O4 nanospheres was designed and developed for potential anticancer treatment in the present study. The hollow mesoporous NiFe2O4 nanospheres were fabricated through a template-free solvothermal approach and the possible formation mechanism of this structure was proposed. The products were investigated
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Development of an electrochemical biosensor for the detection of mammary gland carcinoma using molybdenum enhanced poly taurine nano-biofilms confirmed pathological findings Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-04-27 Hassan Nasrollahpour, Balal Khalilzadeh, Reza Rahbarghazi, Nevin Erk, Mohammad-Reza Rashidi, Abdolhossein Naseri
Developing high-performance sensing frameworks for diagnosing anaplastic changes is the subject of debate. The lack of on-time diagnosis in patients with suspicious cancers can affect the prognosis and survival rate. As a correlate, the emergence of de novo strategies for developing transducing frameworks has an inevitable role in advanced biosensing. The combination of green chemistry procedures with
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Magnetohyperthermia-synergistic glioma cancer therapy enabled by magnetic graphene oxide nanoheaters: promising nanostructure for in vitro and in vivo applications Cancer Nanotechnol. (IF 5.7) Pub Date : 2023-04-26 Roghayeh Sheervalilou, Samideh Khoei, Sepideh Khoee, Milad Shirvaliloo, Elaheh Sadri, Sakine Shirvalilou, Mina Goudarzi
In the present study, a magnetohyperthermia (MH)-based therapy is introduced as an effective treatment for deep-seated tumors especially glioma, which combines the magnetothermal effect and the reactive oxygen species (ROS) induced with magnetic graphene oxide (GOMNPs) nanoheaters to overcome the issue of limited therapeutic efficacy in the current magnetothermal therapeutic strategy. Magnetic graphene