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  • Apatinib Combined With Radiotherapy Enhances Antitumor Effects in an In Vivo Nasopharyngeal Carcinoma Model.
    Cancer Control (IF 1.99) Pub Date : 2020-05-18
    Shanshan Liu,Fei Wu,Yanling Zhang,Rongsheng Qin,Nengping Zhu,Yuan Li,Mingting Wang,Qin Zeng,Danna Xie,Yinghua Li,Juan Fan,Yunwei Han

    Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are highly expressed in nasopharyngeal carcinoma; therefore, blocking the binding of VEGF and VEGFR may be a potential way to treat nasopharyngeal carcinoma. Apatinib inhibits tumor angiogenesis. Previous studies have suggested that treatment with apatinib has an antitumor effect on nasopharyngeal carcinoma. This study will investigate

    更新日期:2020-05-18
  • Resistance is not the end: lessons from pest management.
    Cancer Control (IF 1.99) Pub Date : 2020-05-14
    Christopher J Whelan,Jessica J Cunningham

    The "war on cancer" began over 40 years ago with the signing of the National Cancer Act of 1971. Currently, complete eradication has proven possible in early stage premetastatic disease with increasingly successful early detection and surgery protocols; however, late stage metastatic disease remains invariably fatal. One of the main causes of treatment failure in metastatic disease is the ability of

    更新日期:2020-05-14
  • Gaps in Knowledge and Understanding of Patients With Metastatic Breast Cancer in Mexico.
    Cancer Control (IF 1.99) Pub Date : 2020-05-12
    Cynthia Villarreal-Garza,Fernanda Mesa-Chavez,Edna Anakarenn Lopez-Martinez,Alan Fonseca,Claudia Pineda,Fernanda Rivera,Marisol Garcia-Garcia,Sylvia de la Rosa-Pacheco,Alejandro Mohar,Corrine Ellsworth-Beaumont,Alejandra Platas

    There is paucity of data regarding the knowledge and understanding of patients with metastatic breast cancer (MBC) about their disease stage and treatment goals. This study assessed these patients' awareness of MBC incurability, topics reviewed with their oncologist, perceptions of having enough knowledge to participate in treatment decision-making, most helpful information source, and satisfaction

    更新日期:2020-05-12
  • Novel Prognostic Models for Patients With Penile Carcinoma.
    Cancer Control (IF 1.99) Pub Date : 2020-05-12
    Monica E Reyes,Heloise Borges,Muhamed Said Adjao,Nisha Vijayakumar,Philippe E Spiess,Matthew B Schabath

    Although penile carcinoma is a rare malignancy, there is still an unmet need to identify prognostic factors associated with poor survival. In this study, we utilized demographic and clinical information to identify the most informative variables associated with overall survival in patients with penile cancer. From a full model including all covariates found to be statistically significant in univariable

    更新日期:2020-05-12
  • Feasibility of Plasma-Methylated SFRP2 for Early Detection of Gastric Cancer.
    Cancer Control (IF 1.99) Pub Date : 2020-05-07
    Jin Miao,Yi Liu,Guodong Zhao,Xiaoyu Liu,Yong Ma,Hui Li,Shiming Li,Yun Zhu,Shangmin Xiong,Minxue Zheng,Sujuan Fei

    Gastric cancer (GC) is fifth most frequently diagnosed cancer and second leading cause of cancer in China. More than 80% of GC are diagnosed at an advanced stage due to low uptake rate of invasive screening method. The performance of methylated SFRP2 test was evaluated in 236 plasma samples, including 92 patients with GC, 16 intestinal metaplasia patients, 26 gastric fundic gland polyp patients, 13

    更新日期:2020-05-07
  • Cost-Effectiveness of Primary HPV Screening Strategies and Triage With Cytology or Dual Stain for Cervical Cancer.
    Cancer Control (IF 1.99) Pub Date : 2020-05-06
    Tanitra Tantitamit,Nipon Khemapech,Piyalamporn Havanond,Wichai Termrungruanglert

    To identify the optimal cost-effective strategy for cervical cancer screening program in Thailand by comparing the different algorithms which based on the use of primary human papilloma virus (HPV) assay. We use a Microsoft Excel-based spreadsheet to calculate the accumulated cases of preinvasive and invasive cervical cancer and the budget impact of each screening program. The model was developed to

    更新日期:2020-05-06
  • Locally Advanced Oral Cavity Cancers: What Is The Optimal Care?
    Cancer Control (IF 1.99) Pub Date : 2020-04-27
    Rajab Alzahrani,Arwa Obaid,Hadi Al-Hakami,Ahmed Alshehri,Hossam Al-Assaf,Reem Adas,Eman Alduhaibi,Nabil Alsafadi,Suliman Alghamdi,Majed Alghamdi

    Patients with oral cavity cancers often present late to seek medical care. Surgery is usually the preferred upfront treatment. However, surgical resection cannot be achieved in many cases with advanced disease without major impact on patient's quality of life. On the other hand, radiotherapy (RT) and chemotherapy (CT) have not been employed routinely to replace surgery as curative treatment or to facilitate

    更新日期:2020-04-27
  • Prostate Cancer in Latin America: Challenges and Recommendations.
    Cancer Control (IF 1.99) Pub Date : 2020-04-21
    Rodolfo Borges Dos Reis,Alejandro Alías-Melgar,Andrés Martínez-Cornelio,Silvia P Neciosup,Juan Pablo Sade,Marcos Santos,Gustavo Martin Villoldo

    Prostate cancer (PCa) is the most frequent tumor among Latin American (LATAM) men. The incidence of de novo metastatic PCa is higher in LATAM than other parts of the world, and demographic changes in the region have increased disease burden. However, region-specific information regarding prevalence, progression, and treatment effectiveness is not currently available for nonmetastatic, castration-resistant

    更新日期:2020-04-23
  • Radioactive Iodine Therapy in Patients With Thyroid Carcinoma With Distant Metastases: A SEER-Based Study.
    Cancer Control (IF 1.99) Pub Date : 2020-04-15
    Chenyuan Li,Qi Wu,Shengrong Sun

    Distant metastasis (DM) is the dominant negative prognosis for thyroid carcinoma. Radioactive iodine (RAI) therapy serves as an effective treatment for thyroid carcinoma. However, resistance to RAI occurs in patients with DMs. The present study aims to discriminate patients who may benefit from RAI. We extracted patients with thyroid cancer in the Surveillance, Epidemiology, and End Results program

    更新日期:2020-04-20