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Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis J. Cancer (IF 3.9) Pub Date : 2024-3-4 Zhengrui Liu, Jia Wang, Siman Xie, Benteng Zhang, Yan Yuan, Huaizi Fu, Hongyun Hao, Li Sun, Shengtao Yuan, Jian Ding, Hong Yu, Mei Yang
Aim of the study: To investigate the anti-tumor effects of Lasiokaurin on breast cancer and explore its underlying molecular mechanism./nMaterials and methods: In this study, MTT assay, plate colony formation assays, soft agar assay, and EdU assay were employed to evaluate the anti-proliferation effects of LAS. Apoptosis and cell cycle distribution were detected by flow cytometry. The molecular mechanism
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c-Rel is a Novel Oncogene in Lung Squamous Cell Carcinoma Regulating Cell Proliferation and Migration J. Cancer (IF 3.9) Pub Date : 2024-3-4 Renru Luo, Qiongyu Liu, Zheyu Hu, Wanqin Dai, Shuwei Huang, Jianjiang Xie, Shuquan Wei, Chuwen Lin
Lung squamous cell carcinoma (LUSC) accounts for approximately 25% to 30% of lung cancers, but largely no targeted therapy is available against it, calling for identification of new oncogenes in LUSC growth for new therapeutic targets. In this study, REL was identified through a screening for oncogenes that are highly amplified in human LUSC. Its expression was associated with poor prognosis in LUSC
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Unveiling the STAT3-ACC1 axis: a key driver of lipid metabolism and tumor progression in non-small cell lung cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Hong Zhai, Tiansheng Zheng, Lihong Fan
Background and Objective: Lung cancer is a prevalent global malignancy, and investigating the metabolic reprogramming of tumor cells has significant therapeutic implications. This study aims to explore the molecular mechanism driving the progression of non-small cell lung cancer (NSCLC), with a specific emphasis on the STAT3-ACC1-FAS axis involved in fatty acid synthesis./nMethods: The levels of Signal
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Impact of LINC00312 gene polymorphism coupled with habitual risks on buccal mucosa cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Hui-Ting Hsu, Yen-Ting Lu, Yi-Tzu Chen, Ming-Tai Hsing, Chun-Wen Su, Shih-Chi Su, Chiao-Wen Lin, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of LINC00312 single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two LINC00312 SNPs, namely
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Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway J. Cancer (IF 3.9) Pub Date : 2024-3-4 Qiao Zheng, Shengnan Jing, Lin Hu, Xiangrui Meng
Objective: To investigate the inhibitory effect of EVO on colorectal cancer (CRC) growth and further explore the potential mechanism involving the RTKs-mediated PI3K/AKT/p53 signaling pathway./nMethods: Firstly, the inhibitory effect of EVO on CRC cells was detected in vitro by cell viability assay and colony formation assay. The effects of EVO on spatial migration and invasion capacity of cells were
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CMTM6: A Critical Prognostic Indicator in Non-Small Cell Lung Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Fang Dai, Yu-lian Duan, Qiang Feng, Shu-Ling Song, Ju-Lun Yang, Tao Lv
While CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)'s role in stabilizing PD-L1 and immune evasion within tumors is established, its expression in lung cancer tissue and adjacent macrophages remains uncertain. The study aimed to elucidate this ambiguity by investigating CMTM6's role in non-small cell lung cancer (NSCLC) prognosis. Employing immunohistochemical staining on 141 NSCLC and
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Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells J. Cancer (IF 3.9) Pub Date : 2024-3-4 Shuangze Han, Sijin Chen, Jidong Wang, Sheng Huang, Yeqing Xiao, Gaoyan Deng
Highly activated aerobic glycolysis provides the metabolic requirements for tumor cell growth and proliferation. Erianin, a natural product isolated from Dendrobium chrysotoxum Lindl, has been reported to exert antitumor activity in multiple cancers. However, whether Erianin exerts inhibitory effects on aerobic glycolysis and the inherent mechanism remain poorly defined in non-small cell lung cancer
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Systematic Analysis to Identify the MIR99AHG-has-miR-21-5p-EHD1 CeRNA Regulatory Network as Potential Biomarkers in Lung Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Mengju He, Hui Zhang, Yanfei Zhang, Yicen Ding, Fei Zhang, Yani Kang
Lung cancer (LC) remains an extremely lethal disease worldwide, and effective prognostic biomarkers are at top priority. With the rapid development of high-throughput sequencing and bioinformatic analysis methods, the quest to characterize cancer transcriptomes continues to move forward. However, the integrated systematic analysis of lncRNA-miRNA-mRNA regulatory network in LC is lacking. In this study
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Role of Epstein-Barr Virus in Breast Cancer: Correlation with Clinical Outcome and Survival Analysis J. Cancer (IF 3.9) Pub Date : 2024-3-4 Yi-Chiung Hsu, Ming-Han Tsai, Guani Wu, Chien-Liang Liu, Yuan-Ching Chang, Hung-Bun Lam, Pei- Yu Su, Chun-Fan Lung, Po-Sheng Yang
Background: Breast cancer is the most prevalent cancer among women worldwide. The potential involvement of Epstein-Barr virus (EBV) in breast cancer pathogenesis has been a subject of debate, but its correlation with clinical outcomes remains uncertain./nMethods: In this study, we collected 276 pathologically confirmed breast cancer tissue samples from the tissue bank of MacKay Memorial Hospital and
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Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk J. Cancer (IF 3.9) Pub Date : 2024-3-4 Dengfeng Zhang, Jing Li, Tianxing Lu, Fangchao Zhao, Pengfei Guo, Zhirong Li, Xiaoliang Duan, Yishuai Li, Shujun Li, Jianhang Li
Background: Lung cancer and oesophageal cancer are prevalent malignancies with rising incidence and mortality worldwide. While some environmental and behavioural risk factors for these cancers are established, the contribution of genetic factors to their pathogenesis remains incompletely defined. This study aimed to interrogate the intricate genetic relationship between lung cancer and oesophageal
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CFL1 is Implicated in Chronic Myeloid Leukemia Response during Imatinib Therapy J. Cancer (IF 3.9) Pub Date : 2024-3-4 Xiufeng Yin, Xia Li, Hao Jiang, Xiangjie Lin, Zhixin Ma, Xiaochang Chen, Qibei Teng, Jin Zhang, Jie Jin
Cofilin (CFL1) is one critical member of the actin deploy family (ADF). Overexpression of CFL1 is associated with aggressive features and poor prognosis in malignancies. We evaluated the expression of CFL1 in patients with chronic myeloid leukemia in the chronic phase (CML-CP), acute myelocytic leukemia (AML) and healthy controls. The role of CFL1 in imatinib therapy was also investigated using cell
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Uncovering Microbial Composition of the Tissue Microenvironment in Bladder Cancer using RNA Sequencing Data J. Cancer (IF 3.9) Pub Date : 2024-3-4 Ruiqian Yao, Bin Ai, Zeyi Wang, Bing Shen, Geng Xue, Dong Yu
Purpose: Bladder cancer (BC) is one of the top 10 common tumors in the world. It has been reported that microbiota can colonize tissues and play important roles in tumorigenesis and progression. However, the current understanding of microorganisms in the BC tissue microenvironment remains unclear./nMethods: In this study, we integrated the RNA-seq data of 479 BC tissue samples from seven datasets combined
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A Retrospective Analysis of Azvudine in Patients with COVID-19 and Pre-existing Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Fangyu Li, Keao Zheng, Xueyan Qi, Kaixia Cui, Jing Yang, Zhiying Hao
Objectives: Azvudine has been recommended as a potential treatment for the recently discovered Coronavirus disease (COVID-19) in 2019. However, the effectiveness of Azvudine in individuals who have both COVID-19 and pre-existing cancer remains uncertain. Consequently, we undertook a retrospective analysis to evaluate the clinical efficacy of Azvudine therapy in hospitalized patients with COVID-19 and
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Enhancement of Tumorigenicity, Spheroid Niche, and Drug Resistance of Pancreatic Cancer Cells in Three-Dimensional Culture System J. Cancer (IF 3.9) Pub Date : 2024-3-2 Hao-Chien Hung, Tsui-Lien Mao, Ming-Huei Fan, Guan-Zhi Huang, Ainani Priza Minhalina, Chi-Long Chen, Chao-Lien Liu
The three-dimensional (3D) cell culture technique has been applied comprehensively as a variable platform for medical research, biochemical signal pathway analysis, and evaluation of anti-tumor treatment response due to an excellent recapitulation of a tumor microenvironment (TME) in the in vitro cultured cancer cells. Pancreatic cancer (PaC) is one of the toughest malignancies with a complex TME and
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MiR-15b-3p weakens bicalutamide sensitivity in prostate cancer via targeting KLF2 to suppress ferroptosis J. Cancer (IF 3.9) Pub Date : 2024-3-2 Chunlin Zhang, Haitao Yu, Xuesong Bai, Xiang Zhou, Zhenwei Feng, Yang Li, Xiang Peng, Yuhua Mei, Li Li, Xin Gou, Yuanzhong Deng, Guo Chen
Bicalutamide (BIC) resistance impedes the treatment of prostate cancer (PCa) and seems to involve ferroptosis; however, the underlying mechanism remains unclear. Our study aimed to explore how miR-15b-3p modulates ferroptosis in response to BIC resistance and determine whether the miRNA is suitable for early screening of PCa. Here, we found that PCa tissues had significantly higher miR-15b-3p expression
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Identification of T-cell exhaustion-related genes and prediction of their immunotherapeutic role in lung adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Chaoqun Lian, Feifan Li, Yiluo Xie, Linxiang Zhang, Huili Chen, Ziqiang Wang, Xinyu Pan, Xiaojing Wang, Jing Zhang
Background: Lung adenocarcinoma ranks as the second most widespread form of cancer globally, accompanied by a significant mortality rate. Several studies have shown that T cell exhaustion is associated with immunotherapy of tumours. Consequently, it is essential to comprehend the possible impact of T cell exhaustion on the tumor microenvironment. The purpose of this research was to create a TEX-based
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Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Luying Gao, Ruifeng Liu, Yu Xia, Aonan Pan, Xinlong Shi, Liyuan Ma, Jiang Ji, Ya Hu, Xiaoyi Li, Yuang An, Nengwen Luo, Zhiyong Liang, Liangrui Zhou, Yuxin Jiang
Objective: To explore the potential value of a novel marker, KIF-12, in the progression and prognosis of papillary thyroid carcinoma (PTC) through integrative bioinformatics analysis, and clinical sample validation of the prognostic value of KIF-12./nMaterials and Methods: We extracted the clinicopathological data of 502 PTC patients from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset to
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KRT80 Promotes Lung Adenocarcinoma Progression and Serves as a Substrate for VCP J. Cancer (IF 3.9) Pub Date : 2024-2-25 Shanhua Huang, Weilai Tong, Bowen Yang, Li Ma, Jiaming Zhang, Chunliang Wang, Linlin Xu, Jinhong Mei
Background: Keratin 80(KRT80) encodes a type II intermediate filament protein, known for maintaining cell integrity of cells and its involvement in the tumorigenesis and progression of various cancers. However, comprehensive research on its relevance to lung adenocarcinoma remains limited./nMethods: In this study, we utilized multiple databases to investigate the transcriptional expression of KRT80
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Carbon ion irradiation combined with PD-1 inhibitor trigger abscopal effect in Lewis lung cancer via a threshold dose J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ruifeng Liu, Yichao Geng, Hongtao Luo, Qiuning Zhang, Zhen Yang, Shan Li, Shilong Sun, Zhiqiang Liu, Meng Dong, Tianqi Du, Tuanjie Che, Xiaohu Wang
Background and goal: Carbon ion beam is radio-biologically more efficient than photons and is beneficial for treating radio-resistant tumors. Several animal experiments with tumor-bearing suggest that carbon ion beam irradiation in combination with immunotherapy yields better results, especially in controlling distant metastases. This implies that carbon ion induces a different anti-tumor immune response
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Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Yongping Zhang, Ping Sui, Cheng Zhong, Jiansheng Liu
Background: Hepatocellular carcinoma often results in late-stage diagnosis, leading to decreased treatment success. To improve prognosis, this study integrates cuproptosis with immune risk scoring models for HCC patients./nMethod: We identified differentially expressed genes connected to cuproptosis and immune responses using Pearson correlation. A risk signature was then constructed via LASSO regression
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DOT1L promotes expression of CD44 through the Wnt/β-catenin signaling pathway in early gastric carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ping Li, Zhou Zhang, Ping Sun
To assess telomere silencing 1-like (DOTIL) gene expression within gastric cancer (GC) tissues as well as its function of promoting cancer stem cell (CSC)-mediated epithelial-mesenchymal switching, tissue samples from 8 patients each in 3 stages (normal, low-grade intraepithelial neoplasia (LGIN), as well as early gastric carcinoma (EGC)) were collected for whole-exome sequencing, which revealed differentially
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LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer J. Cancer (IF 3.9) Pub Date : 2024-2-25 Yingqiu Hu, Yushan Hu, Xuan Lu, Hongliang Luo, Ziwen Chen
LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant expression patterns of LINC00839 have been observed across diverse cancer tissues and cell lines. LINC00839 emerges as an oncogenic factor in tumorigenesis and exerts a positive influence on tumor-associated behaviors. Its therapeutic
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Threatment Strategies for Recurrent Hepatocellular Carcinoma Patients: Ablation and its Combination Patterns J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ya'ning Zhao, Jun Bai, Xi Wang, Yaoren Zhang, Xiaohong Yan, Jun'an Qi, Xueyan Xia, Yuansong Feng, Baojun Duan
With the development of guidance technology and ablation equipment, ablative procedures have emerged as important loco-regional alternatives to surgical resection for recurrent hepatocellular carcinoma (rHCC) patients. Currently, ablation modalities used in clinical practice mainly include radiofrequency ablation (RFA), microwave ablation (MWA), laser ablation (LA), cryoablation (CRA), high-intensity
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Advances in Drug Therapy for Metastatic Pancreatic Ductal Adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Jianjun Gao, Jiangang Wang, Canghai Guan, Wujiang Shi, Qingfu Dong, Jialin Sheng, Xinlei Zou, Zhaoqiang Xu, Yifei Ge, Ziyue Huang, Jiehan Li, Haolin Bao, Yi Xu, Yunfu Cui, Xiaoxue Xu, Xiangyu Zhong
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis. A large number of patients with PDAC develop metastases before they are diagnosed with metastatic pancreatic cancer (mPDAC). For mPDAC, FOLFIRINOX or gemcitabine plus nab-paclitaxel are the current first-line treatments. It is important to note, however, that many patients will fail chemotherapy because
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CHRNA9 as a New Prognostic Marker and Potential Therapeutic Target in Glioma J. Cancer (IF 3.9) Pub Date : 2024-2-24 Xiaoshan Ma, Ren Geng, Yao Zhao, Wanzhen Xu, Yao Li, Yining Jiang, Yuanhao Liu, Liyan Zhao, Yunqian Li
Background: The nicotinic acetylcholine receptor (nAChR) subunit alpha-9 (CHRNA9) is a unique cholinergic receptor, which is involved in tumor proliferation, apoptosis, metastasis and chemotherapy resistance. However, the correlation between the expression level of CHRNA9 in glioma and the clinical features and prognosis of glioma patients has not been clarified. The aim of this study was to verify
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DHEA down-regulates mitochondrial dynamics and promotes apoptosis of lung adenocarcinoma cells through FASTKD2 J. Cancer (IF 3.9) Pub Date : 2024-2-24 Yan-Fei Zhang, Liu-Liu Yuan, Zong-Can Wang, Wen-Bin Zhuang, Wen-Jia Zhang, Hai-Tao Liu, Ming Li, Li-Hong Fan
Background: DHEA is a steroid hormone produced by the gonads, adrenal cortex, brain, and gastrointestinal tract. While the anti-obesity, anti-atherosclerosis, anti-cancer, and memory-enhancing effects of DHEA have been substantiated through cell experiments, animal studies, and human trials, the precise mechanisms underlying these effects remain unclear. Altered mitochondrial dynamics can lead to mitochondrial
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CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway J. Cancer (IF 3.9) Pub Date : 2024-2-24 Rui Sun, Xucan Tu, Shixin Chan, Xu Wang, Yizhong Ji, Zhenglin Wang, Zhen Yu, Xiaomin Zuo, Qing Zhang, Jiajie Chen, Qijun Han, Ming Wang, Hu Zhao, Huabing Zhang, Wei Chen
Colorectal cancer (CRC) seriously endangers human health owing to its high morbidity and mortality. Previous studies have suggested that high expression of CBX2 may be associated with poor prognosis in CRC patients. However, its functional role in CRC remains to be elucidated. Herein, we found that CBX2 overexpression in colorectal cancer tissue compared with adjacent tissues. Additionally, forest
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Targeted regulation of miR-154-5p/Cullin2 pathway by hsa_circ_TRIM22 in promoting human papillomavirus 16 positive cervical cancer progression J. Cancer (IF 3.9) Pub Date : 2024-2-24 Weihong Zhao, Songquan Wen, Xiuting Wang, Jingfang Wang, Lili Zhang, Tong Wang
Background. Tripartite motif-containing 22 (TRIM22) is characterized by a canonical RING domain with ubiquitin E3 ligase activity and is closely associated with tumorigenesis. As a product of TRIM22 transcription, whether hsa_circ_TRIM22 has a function of regulating tumorigenesis is unclear. Thus, we aimed to explore the role and mechanism of hsa_circ_TRIM22 in human papillomavirus (HPV) 16 positive
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The Analysis of ceRNA Networks and Tumor Microenvironment in Endometrial Cancer J. Cancer (IF 3.9) Pub Date : 2024-2-24 Jian Huang, Xiaoyue Yang, Shen Xu, Ping Li
Background: Endometrial carcinoma is a life-threatening and aggressive tumor that affects women worldwide. ceRNAs and carcinoma-infiltrating immunocytes can be associated with tumor formation and progression. Therefore, investigating the unique mechanisms underlying endometrial carcinoma is crucial./nMethods: Prognostic nomograms were constructed based on the differentially expressed genes between
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Clinical and laboratory features of different types of cancer-associated thrombosis. J. Cancer (IF 3.9) Pub Date : 2023-10-30 Yanhong Liu,Rufei Ma,Yue Li,Lan Gao
Background: Patients with cancer showed a high incidence of venous thromboembolism (VTE) with a poor prognosis. The risk factors for VTE in different types of cancers may differ. Methods: The clinical features and laboratory test results of cancer patients with VTE in Henan Provincial People's Hospital from 2014 to 2020 were evaluated and compared. Results: Among the eligible patients, gastrointestinal
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PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway. J. Cancer (IF 3.9) Pub Date : 2023-10-30 Yang Xia,Xinyu Feng,Yunye Ning,Wei Zhang,Zhenli Hu,Qianqian Chen,Jun Wang,Hao Qin,Yang Lu,Yuchao Dong
Purpose: PLEKHG2 is a member of the diffuse B-cell lymphoma family. The function of PLEKHG2 in NSCLC was still unclear. This study aimed to investigate the relationship between the upregulated expression of PLEKHG2 and the prognosis of NSCLC and to revealed its mechanisms. Materials and methods: The expression of PLEKHG2 in NSCLC patients and its relationship with prognosis were first determined by
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Construction of the metabolism-related models for predicting prognosis and infiltrating immune phenotype in lung squamous cell carcinoma. J. Cancer (IF 3.9) Pub Date : 2023-10-24 Zeming Ma,Liang Wang,Xiaoyun Huang,Hong Ji,Haoyang Wang,Yue Yang,Yuanyuan Ma,Jinfeng Chen
Purpose: Cancers often display disorder metabolism, which closely related to the poor outcome of patients. We aimed to establish prognostic models using metabolism-associated genes, and identify the key factor involved in metabolism in lung squamous cell carcinoma (LUSC). Materials and Methods: R package 'TCGA biolinks' was used to download the mRNA sequencing data of LUSC from TCGA. The clusterProfiler
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Advances in Radiomics Research for Endometrial Cancer: A Comprehensive Review. J. Cancer (IF 3.9) Pub Date : 2023-10-24 Wenxiu Guo,Tong Wang,Binglin Lv,Jie Jiang,Yao Liu,Peng Zhao
Endometrial cancer (EC) is a common gynecologic malignancy, with a rising trend in related mortality rates. The assessment based on imaging examinations contributes to the preoperative staging and surgical management of EC. However, conventional imaging diagnosis has limitations such as low accuracy and subjectivity. Radiomics, utilizing advanced feature analysis from medical images, extracts more
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Identification of A Novel Gene Signature Combining Ferroptosis- and Immunity-Related Genes for Prognostic Prediction, Immunotherapy and Potential Therapeutic Targets in Gastric Cancer. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Liwei Wang,Zhuozhuo Li,Zi Li,Yuanyuan Ren,Lu Qian,Yi Yu,Wenzhen Shi,Yuyan Xiong
Gastric cancer (GC) is one of the most prevalent cancers worldwide. Ferroptosis and the immune status of tumor tissue play vital roles in the initiation and progression of GC. However, the role and functional mechanisms of ferroptosis- and immunity-related genes (FIRGs) in GC pathogenesis and their correlations with GC prognosis have not been elucidated. We aim to establish a prognostic prediction
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MUC15 is an independent prognostic factor that promotes metastases of MYCN non-amplified neuroblastoma. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Huiqin Guo,Wei-Xin Zhang,Qiu-Yan Zhang,Meng Li,Hai-Yun Wang,Di Li,Jiabin Liu,Zhenjian Zhuo,Jing He,Lei Miao,Huimin Xia
Background: Neuroblastoma (NB) is a cancer that arises from neural-crest-derived sympathoadrenal lineage. Less is known about the pathogenesis and molecular characteristics of MYCN non-amplified (MYCN-NA) NB. Methods: We constructed a signature model targeting mucin family according to RNA sequencing data from GSE49710 dataset, and validated the prognostic performance. We also analyzed the gene expression
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Pharmacological effects of Niraparib and its combination with angiogenic inhibitor in ovarian cancer. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Huiwen Liu,Xue Chen,Chenpeng Tang,Xiangjian Luo
Background: Ovarian cancer (OC) represents the seventh most lethal female tumors worldwide. The combination of PARP inhibitor (PARPi) and angiogenic inhibitor has been shown to be effective as a first-line or second-line maintenance regimen to synergistically exert antitumor effects, which prompts us to further evaluate the therapeutic effect of the combination of PARP inhibitor Niraparib and anti-angiogenic
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miR-134-3p driven by anisomycin impairs ovarian cancer stem cell activity through inhibiting GPR137 expression. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Lele Ling,Yichao Wen,Haiyang Chen,Ying Xiong,Xin Liu,Juan Chen,Te Liu,Bimeng Zhang
Background: Ovarian cancer recurrence and metastasis are predominantly attributed to ovarian cancer stem cells; however, the mechanism by which anisomycin regulates human ovarian cancer stem cells (HuOCSCs) remains unclear. Methods: cDNA microArray was used to screen microRNAs (miRNAs) targeted by anisomycin, and RT-qPCR validated the miRNA targets. TargetScan database, GO enrichment analysis, and
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APOBEC3A suppresses cervical cancer via apoptosis. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Zishuai Li,Haiwei He,Xiangyu Ren,Yifan Chen,Wenbin Liu,Rui Pu,Letian Fang,Yiwei Shi,Donghong Liu,Jiayi Zhao,Zheyun Niu,Mingjuan Xu,Guangwen Cao
Background: Family members of Apolipoprotein B mRNA-editing enzyme catalytic 3 (APOBEC3) play critical roles in cancer evolution and development. However, the role of APOBEC3A in cervical cancer remains to be clarified. Methods: We used bioinformatics to investigate APOBEC3A expression and outcomes using The Cancer Genome Atlas (TCGA)-cervical squamous cell carcinoma and endocervical adenocarcinoma
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Lapatinib dysregulates HER2 signaling and impairs the viability of human uveal melanoma cells. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Wenying Shu,Janney Z Wang,Xue Zhu,Ke Wang,Svetlana Cherepanoff,R Max Conway,Michele C Madigan,Li-Anne Lim,Hong Zhu,Ling Zhu,Michael Murray,Fanfan Zhou
Uveal melanoma (UM) is the principal type of intraocular malignancy in adults. Up to 50% of UM patients develop metastatic disease with very poor survival. There are few drugs available to treat the primary or metastatic UM. This study was undertaken to evaluate the anti-cancer effect of lapatinib and corroborate the potential of HER2 inhibition in the treatment of UM. The anti-UM activity of lapatinib
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Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Ningxin Li,Huan Li,Shufen Zhou,Qingyu Zhang,Guangtao Li,Huanfa Yi,Yahui Liu,Zhanchuan Ma
Hepatocellular carcinoma is one of the most common malignant tumors in the world. It has been reported that fibronection type III domain containing family plays an important role in the formation and development of a variety of tumors, but the role of FNDC4 is still unclear. In our study, we found that FNDC4 was highly expressed in normal liver tissues but abnormally expressed at low levels in liver
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Potentially Functional Genetic Variants in the NRF2 Signaling Pathway Genes are Associated With HBV-related Hepatocellular Carcinoma Survival. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Rongbin Gong,Moqin Qiu,Ji Cao,Zihan Zhou,Yuying Wei,Qiuping Wen,Qiuling Lin,Xiaoxia Wei,Xiumei Liang,Yanji Jiang,Peiqin Chen,Junjie Wei,Shicheng Zhan,Yingchun Liu,Hongping Yu
The nuclear factor E2-related factor 2 (NRF2) signaling pathway is one of the most important cell defense pathways. However, it is unclear whether genetic variants in NRF2 signaling pathway genes are associated with the survival of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). In the present study, we utilized a new hypothesis-driven approach based on biological pathways to investigate
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Downregulated M6A modification and expression of circRNA_103239 promoted the progression of glioma by regulating the miR-182-5p/MTSS1 signalling pathway. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Shoudan Zhang,Peng Zhang,Anyi Wu,Zhipeng Xu,Shilu Huang,Xinglei Liu,Jun Dong
Glioma is a common type of tumor in the central nervous system, and the mortality is high. The prognosis of advanced glioma patients remains poor, and the therapeutic strategies need to be developed. The roles of circRNAs in glioma remain largely unknown. The aim of this study was to explore the functions circRNA_103239 in the biological behaviour changes of glioma cells. The expression of circRNA_103239
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SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2. J. Cancer (IF 3.9) Pub Date : 2023-10-16 Xiaoke Yu,Guang Feng,Rui Nian,Shuai Han,Meiling Ke,Ling Wang,Wanjun Li,Shan Tian,Hongzhao Lu
Breast cancer has the characteristics of high metastasis and recurrence and ranks first in incidence and mortality among female malignant tumors. Shc SH2-domain binding protein 1 (SHCBP1) is an important protein in intracellular signal transduction and cell division, but the role of SHCBP1 in breast cancers remains elusive. Here, we found that SHCBP1 deficiency inhibited the proliferation of breast
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Knowledge and awareness of warning signs about Lung cancer among Pharmacy and Nursing undergraduates in Riyadh, Saudi Arabia - an observational study. J. Cancer (IF 3.9) Pub Date : 2023-10-09 Omaimah A Qadhi,Alya Alghamdi,Dalal Alshael,Maha Fayez Alanazi,Wajid Syed,Ibrahim Nasser Alsulaihim,Mahmood Basil A Al-Rawi
Background: Cancer is becoming more common, regardless of gender or type. Cancer was determined to be the leading cause of death, with lung cancer (LC) patients having the highest rate of cancer-related deaths. The purpose of this study was to analyze undergraduates' knowledge and awareness of LC early warning signs in Riyadh, Saudi Arabia. Methods: Between May and September 2022, a cross-sectional
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Development of A Nomogram for Progression-free Survival in Patients with Stage II/T3N0 Nasopharyngeal Carcinoma to Explore Different Treatment Modalities. J. Cancer (IF 3.9) Pub Date : 2023-10-09 Chang Yan,Rong Zhao,Kai-Hua Chen,Biao-You Chen,Chao-Jun Zhang,Xi Chen,Wan-Wan Meng,Lin Lai,Song Qu,Xiao-Dong Zhu
Purpose To explore the prognostic value of clinical and serological risk factors for progression-free survival (PFS) in stage II and T3N0 nasopharyngeal carcinoma (NPC) and construct a nomogram based on these factors. Additionally, to investigate the long-term survival and short-term toxic reactions of patients in different risk stratification under different treatment modalities. Methods The patients
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Prognosis, Immune Microenvironment Infiltration and Immunotherapy Response in Clear Cell Renal Cell Carcinoma Based on Cuproptosis-related Immune Checkpoint Gene Signature. J. Cancer (IF 3.9) Pub Date : 2023-10-09 Gang Liu,Feifei Li,Yuntian Ge,Yaxing Shi,Fang Ren,Liancheng Zhu
Background: Immune checkpoint genes (ICGs), which are the cornerstone of immunotherapy, influence the incidence and progression of clear cell renal cell carcinoma (ccRCC). It is important to note that there is not much data in the literature to determine how cuproptosis and antitumor immunity are related. Methods: On the basis of The Cancer Genome Atlas ccRCC dataset (n=526), cuproptosis-related ICGs
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Pan-cancer Analysis of the Disulfidptosis-related Gene NCKAP1 and Its Prognostic Value for Lung Adenocarcinoma. J. Cancer (IF 3.9) Pub Date : 2023-10-09 Ankang Zhu,Yan Zong,Shuai Wei,Yinuo Li,Yan Fan,Shaodong Liu,Xingcai Gao
BACKGROUND The nck-associated protein 1 (NCKAP1) of the disulfidptosis-related gene is essential in programmed cell death. However, a comprehensive analysis of the biological significance of NCKAP1 in pan-cancer is lacking. METHODS Gene expression matrices and clinical expression information of cancers were obtained from The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEX) databases
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Distant Metastasis is the Dominant Cause of Treatment Failure after Lateral Lymph Node Dissection in Patients with Lateral Lymph Node Metastasis: Results of the Large Multicenter Lateral Node Study in China. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Kan Li,Feng Wang,Yujuan Jiang,Gong Hong,Zijin Li,Jianwei Liang,Weinan Wu,Wei Xing,Qian Liu
Background: Lateral lymph node (LLN) metastases (LLNM) are often associated with poor prognosis. This study aimed to investigate the prognostic significance and postoperative recurrence pattern in rectal cancer patients with LLNM after LLN dissection (LLND). Materials and Methods: This is a multicenter retrospective case-control study where propensity score-matched (PSM) analysis was introduced. From
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CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Zhiqiang Wu,Liyuan Deng,Jin Tao,Yuhai Lu,Xiaofei Zeng,Weikun Jia,Hu Chen
Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is
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SRY-box transcription factor 21 antisense divergent transcript 1: Regulatory roles and clinical significance in neoplastic conditions and Alzheimer's Disease. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Ling Lei,Guangxi Peng,Hongliang Luo,Wugen Li
SRY-box transcription factor 21 antisense divergent transcript 1 (SOX21-AS1) is a multifaceted long non-coding RNA (lncRNA) that plays diverse roles in both neoplastic conditions and Alzheimer's disease. Its aberrant expression intricately regulates a wide spectrum of cellular processes, spanning from epithelial-mesenchymal transition (EMT), apoptosis, migration, metastasis, and stemness to drug resistance
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Activation of assembly factor for spindle microtubules triggers progression of renal cell carcinoma via Wnt3a pathway. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Zhijun Cao,Yu Li,Chen Xu,Zhiyu Zhang,Zhenfan Wang,Zheng Ma,Pengwei Xu,Xiaofei Sun,Xuefeng He,Jianglei Zhang,Hao Jiang,Gang Li
Renal cell carcinoma, shorted as RCC is a well-known urological cancer with high level of morbidity and mortality. Although the regulatory role of the spindle microtubule assembly factor (ASPM) in tumor progression has been established, its relationship to the development of RCC remains unclear. To determine the significance of this gene in RCC, we examined its expression in RCC patients in the TCGA
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Adverse Event Profile Differences between Trastuzumab Emtansine and Trastuzumab Deruxtecan: A Real-world, Pharmacovigilance Study. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Fen Liu,Guisen Yin,Shuyi Xue,Faisal Ul Rehman,Dehua Liao,Yong Pan
Introduction: Trastuzumab emtansine(T-DM1) and trastuzumab deruxtecan (T-DXd, formerly DS-8201a), the human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate (ADC), are commonly used in metastatic breast cancer. However, their real-world safety profile has not been adequately compared. Objective: We aimed to investigate the adverse event (AE) profile of T-DM1 and T-DXd reported
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Ablation of the GDP-fucose transporter suppresses lung cancer cell proliferation and migration by reducing expression of PD-L1. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Yingshu Zhang,Nianzhu Zhang,Wanli Song,Sabiha Yousuf,Wenzhe Li
Fucosylation, an important post-translational modification, is closely related to the development of tumors. In the microenvironment of lung cancer, expression of PD-L1 and fucosylation is abnormally upregulated. However, the correlation between PD-L1 expression and its fucosylation in lung adenocarcinoma (LUAD) remains unclear. The GDP-fucose transporter (GFT) is a key molecule in cellular fucosylation
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The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: The first review of RBEL1A research with future research directions and challenges. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Ki Lui,Ying Huang,M Saeed Sheikh,Kwok-Kuen Cheung,Wing Yip Tam,Keng-Ting Sun,Ka Ming Cheng,Winnie Wing Man Ng,Anthony Wai-Keung Loh
Research on Rab-like protein 1A (RBEL1A) in the past two decades highlighted the oncogenic properties of this gene. Despite the emerging evidence, its importance in cancer biology was underrated. This is the first RBEL1A critical review covering its discovery, biochemistry, physiological functions, and clinical insights. RBEL1A expression at the appropriate levels appears essential in normal cells
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Molecular Mechanism of Vitamin D Receptor Modulating Wnt/β-catenin Signaling Pathway in Gastric Cancer. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Ying Zhang,Yan Li,Yuzheng Wei,Lei Cong
Background: Gastric cancer is the most common gastrointestinal cancer worldwide. The latest data showed that it was the fourth leading cause of cancer-related death. The unobvious symptom and the difficulties lying in the early diagnosis largely affect the effect of the treatment. Therefore, it becomes particularly important to investigate the related genes and signal transduction pathways in gastric
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Cinobufagin exerts an antitumor effect in non-small-cell lung cancer by blocking STAT3 signaling. J. Cancer (IF 3.9) Pub Date : 2023-10-02 Sunshun Yan,Chunbo Ma,Feng Zhou,Hailun Zheng,Lehe Yang,Zhongxiang Xiao,Jiandong Zhu,Haiyang Zhao,Chengguang Zhao,Xiaoling Xu
Background: Non-small-cell lung cancer (NSCLC) is the most common histological subtype of lung cancer with significant morbidity and mortality rates worldwide. Cinobufagin, the primary component of Chansu and the major active ingredient of cinobufacini, has attracted widespread attention for its excellent anticancer effects, but its activity remains poorly characterized in NSCLC. Methods: The functions
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Enhanced Efficacy of Chemotherapy by Addition of Immune Checkpoint Inhibitors in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung: A Real-World Analysis. J. Cancer (IF 3.9) Pub Date : 2023-09-25 Lingbin Meng,Biwei Cao,Rui Ji,Dung-Tsa Chen,Damian A Laber,Michael Shafique
Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a high-grade malignancy with limited treatment options. Despite promising results of immunotherapy in non-small cell and small cell lung cancers, its benefit in LCNEC remains elusive. Methods: We included 24 patients diagnosed with stage IV LCNEC from the Moffitt Cancer Center database who received systemic therapy between January 2016 and
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High-dose methotrexate, thiotepa, orelabrutinib combined with or without rituximab in primary or secondary central nervous system diffuse large B-cell lymphoma: a single-center retrospective analysis. J. Cancer (IF 3.9) Pub Date : 2023-09-25 Yufeng Li,Yajun Li,Ruolan Zeng,Yizi He,Liang Liang,Lijia Ou,Chang Su,Hui Zhou,Ling Xiao
Purpose: Central nervous system lymphoma (CNSL) is an aggressive non-Hodgkin's lymphoma (NHL) confined to the central nervous system (CNS). Orelabrutinib is an oral second-generation Bruton tyrosine kinase (BTK) inhibitor and a novel therapeutic strategy for CNSL. The purpose of this study was to evaluate the effectiveness and safety of high-dose methotrexate (HD-MTX), thiotepa, and orelabrutinib combined
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Gut microbiota deficiency ameliorates multiple myeloma and myeloma-related bone disease by Th17 cells in mice models. J. Cancer (IF 3.9) Pub Date : 2023-09-25 Jia Liu,Fang Xie,Zhi-Gang Yi,Tao Ma,Wen-Ting Tie,Yan-Hong Li,Jun Bai,Lian-Sheng Zhang
Purpose: Multiple myeloma, the second most common hematological tumor, is currently incurable. Multiple myeloma-related bone disease is a characteristic clinical symptom that seriously affects the survival and prognosis of patients. In recent years, gut microbiota has been shown to play an important role in the occurrence and development of multiple myeloma. However, whether and how it affects the
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Inguinal Lymph Node Metastasis as Sole Manifestation of Ovarian / Fallopian Tube Cancer: a Review of the Literature. J. Cancer (IF 3.9) Pub Date : 2023-09-25 Sofoklis Stavros,Anastasios Potiris,Nikolaos Machairiotis,Alexandros Fotiou,Pavlos Zarogoulidis,Eirini Drakaki,Theodoros Karampitsakos,Christos Koratzanis,Spyridon Michalopoulos,Dionysios Vrachnis,Panagoula Oikonomou,Nikolaou Christina,Charalampos Charalampidis,Stamatios Petousis,Aris Ioannidis,Dimitris Matthaios,Ekaterini Domali,Peter Drakakis
Background: Ovarian/fallopian tube cancer is the deadliest gynecological malignancy. Most cases are diagnosed at an advanced stage, typically after the cancer has spread to the peritoneal cavity, or via lymphatic drainage. The presence of distant lymph node metastasis in the inguinal region is a rare manifestation of lymphatic metastasis. Since the 2014 FIGO staging revision, ovarian cancer patients