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Expression patterns and pathogenesis of Semaphorin class 4 subfamily proteins in solid tumors. Neoplasma (IF 3.0) Pub Date : 2024-01-31 Dongjun Jiang, Xiaoli Chen, Xiuting Li, Jian Qiu, Peng Xu, Xuezhi Li
Semaphorins are originally described as regulators of nervous system development. Besides, members of the semaphorin family play important roles in the growth, metastasis, and angiogenesis of solid tumors. In contrast to the other semaphorin subclasses, semaphorin class 4 has both membrane-bound and active soluble forms. Soluble class 4 semaphorins in body fluids (blood and saliva) may serve as potential
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The role of polyethylenimine-functionalized gold nanoclusters carrying plasmid CMTM5 in impeding the malignant progression of prostate cancer cells by promoting EGFR endocytosis. Neoplasma (IF 3.0) Pub Date : 2024-01-31 Linjin Li, Chengpeng Li, Feilong Miao, Wu Chen, Xianghui Kong, Ruxian Ye, Rui Feng
In this research, polyethylenimine-functionalized gold nanoclusters (PEI-AuNCs) were synthesized for the delivery of plasmid CMTM5 (pCMTM5) to prostate cancer (PCa) cells, with the objective of elucidating the mechanism underlying its anticancer efficacy. The PEI-AuNCs loaded with pCMTM5 (PEI-AuNCs@pCMTM5) tumor-targeting drug delivery system was established. Subsequently, both the obtained PEI-AuNCs
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CCDC86 promotes the aggressive behavior of nasopharyngeal carcinoma by positively regulating EGFR and activating the PI3K/Akt signaling. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Zhi Wang, Tao Zhou, Xubo Chen, Xinhua Zhu, Bing Liao, Jianguo Liu, Siqi Li, Ting Tan, Yuehui Liu
Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck. A number of studies have confirmed that coiled-coil domain-containing protein 86 (CCDC86) plays an important role in the pathogenesis of lymphoma but the role of CCDC86 in NPC has not yet been reported. Here, in vivo and in vitro experiments were conducted to explore whether CCDC86 plays a role in the pathogenesis of NPC
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CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Xinlin Yang, Miao Zhang, Wei Xia, Zhongchao Mai, Ying Ye, Bin Zhao, Yanan Song
ChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) is involved in intracellular glutathione depletion, ferroptosis, and tumorigenesis. The functional role of CHAC1 expression in thyroid carcinoma has not yet been established. The present study aimed to investigate the impact and mechanisms of CHAC1 on ferroptosis and radiation sensitivity in thyroid carcinoma. CHAC1 expression was examined
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Sintilimab, bevacizumab biosimilar, and HAIC for unresectable hepatocellular carcinoma conversion therapy: a prospective, single-arm phase II trial. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Dongming Liu, Han Mu, Changfu Liu, Weihao Zhang, Yunlong Cui, Qiang Wu, Xiaolin Zhu, Feng Fang, Wei Zhang, Wenge Xing, Qiang Li, Tianqiang Song, Wei Lu, Huikai Li
We assessed the efficacy and safety of sintilimab [an anti-programmed death (PD-1)] plus bevacizumab biosimilar (IBI305), and hepatic arterial infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC). The patients received sintilimab (200 mg) plus IBI305 (7.5 mg/kg) and HAIC (FOLFOX for 23 h) and were treated every 3 weeks. The primary endpoint was the objective response
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Innervation density and types of nerves in prostate cancer. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Filip Blasko, Lucia Krivosikova, Pavel Babal, Jan Breza, Branislav Trebaticky, Roman Kuruc, Boris Mravec, Pavol Janega
Innervation of cancerous tissue represents an important pathway enabling the nervous system to influence the processes associated with the initiation, progression, and metastasis of a neoplastic process. In the context of prostate cancer, several papers report the presence of innervation and its modulating effect on the cancer prognosis. However, most of the data are experimental, with limited information
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Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Blanka Rosova, Jan Proks, Alzbeta Filipova, Dimitar Hadzi Nikolov, Renata Chloupkova, Igor Richter, Arpad Szabo, Aneta Rozsypalova, Radoslav Matej, Bohuslav Melichar, Tomas Buchler, Josef Dvorak
The aim of this study was to investigate the prognostic significance of membranous β-catenin and cytoplasmic β-catenin expression in pancreatic cancer patients (pts). One hundred pts with histologically verified exocrine pancreatic ductal adenocarcinoma were retrospectively studied. The membranous β-catenin, cytoplasmic β-catenin, and cell nucleus β-catenin expression were immunohistochemically evaluated
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Treatment for SMARCB1 (INI-1) deficient sinonasal tumor: a single-institution study. Neoplasma (IF 3.0) Pub Date : 2024-1-22 Tian Wang, Jie Wang, Tianci Tang, Li Wang, Yi Li, Xinmao Song
Currently, less than 200 cases of SMARCB1-deficient sinus cancer (SDSC) have been documented. Little information is available about the best treatment options or prognosis for SDSC. From September 2016 to November 2022, the medical records of 22 people with SDSC were evaluated retrospectively. Patient demographics, staging, pathology findings, treatment details, recurrence, metastasis, and survival
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The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix. Neoplasma (IF 3.0) Pub Date : 2024-01-12 Deying Zhao, Shaoxing Sun, Zhiyong Yang, Ping Wang, Hui Qiu
Small-cell neuroendocrine carcinoma of the cervix (SCNCC) is a rare and aggressive tumor with a poor prognosis. Surgical resection followed by adjuvant therapy is the standard treatment for early-stage disease, but the influence of different neo/adjuvant treatment approaches remains unclear. Retrospectively, we collected patients' characteristics and treatments in two medical centers. Disease status
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USP36 plays an oncogenic role in colorectal cancer cells. Neoplasma (IF 3.0) Pub Date : 2024-01-12 Lixiong Luo, Yijiang Li, Rongjie Huang, Ling Li, Chuncai Wu, Qunzhang Zeng
Cancer stem cells (CSCs) have emerged as crucial contributors to tumor relapse and chemoresistance, making them promising targets for treating cancers like colorectal cancer (CRC). However, the mechanisms governing CSC maintenance in CRC remain poorly characterized. In this study, we investigated the potential role of ubiquitin-specific protease 36 (USP36) in CRC. Our bioinformatic analysis revealed
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RASSF1A promotes radiosensitivity in nasopharyngeal carcinoma by promoting FoxO3a and inhibiting the Nrf2/TXNRD1 signaling pathway. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Yishimei Si, Linghan Meng, Bingwen Zhang, Yuanqing Wu, Qianming Du, Jinjing Xu, Jianwei Qi
Radiotherapy is widely used as the first-line treatment for nasopharyngeal carcinoma (NPC). However, the resistance of some patients to treatment lowers its clinical effectiveness. Compared to typical epithelial cells, NPC markedly lowers the Ras-association domain family 1A (RASSF1A) protein expression. RASSF1A overexpression sensitizes NPC cells to radiotherapy. Mechanistically, RASSF1A promotes
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Desmoplasia in non-small cell lung carcinomas is associated with low programmed death-ligand 1 expression and the absence of tumor-infiltrating lymphocytes. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Vladimír Tancoš, Lukáš Plank, Anna Farkašová, Marian Grendár, Alena Mazuráková, Zdenko Huťka, Zuzana Kviatkovská
Programmed death-ligand 1 (PD-L1) is the most widely utilized predictive marker used to identify non-small cell lung carcinoma (NSCLC) patients most suitable for immunotherapy approaches. The relationship between PD-L1 expression, the presence of CD8+ T cells, and other clinicopathological characteristics of NSCLC patients has not been elucidated yet. In this retrospective study, we immunohistochemically
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TRIM11 regulated by m6A modification promotes the progression of cervical cancer by PHLPP1 ubiquitination. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Pu Zhang, Yi Tang, Jing Zhao, Jing Yang, Yan Chen, Yingping Gong, Shengjun Meng, Chuqiang Shu
Cervical cancer (CC) is a common cancer in women and a serious threat to women's lives. TRIM11 has been confirmed as a carcinogen in multiple cancers. Here, we will excavate the detailed mechanism of TRIM11 in CC. CC cell lines and nude mice were experimental subjects in this study. The abundance of genes and proteins was detected using qRT-PCR, western blot, and IHC. Cell proliferation, migration
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Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Yong Yang, Yan-Ping Yang, Mei-Ling Yi, Fang-Ting Huang, Xia Zhu, Guang-Wu Huang
Radiotherapy and chemotherapy have improved the 5-year survival rate of nasopharyngeal carcinoma (NPC) patients, but the side effects generally lead to unsatisfactory clinical efficacy. It's imperative to explore the pathogenesis of NPC to find better diagnostic and therapeutic methods. Small nucleolar RNA host genes (SNHGs) are special lncRNAs, which can be further spliced to produce small nucleolar
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MCM2 promotes the stemness of endometrial cancer cells via the Akt/β-catenin pathway. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Yuening Chu, Xiaoting Jin, Xiaoqing Guo
Minichromosome maintenance complex component 2 (MCM2) is a member of the MCM family and is involved in various cancers. However, the role of MCM2 in endometrial cancer (EC) remains unclear. In this study, we aim to determine the biological function of MCM2 in EC cells and identify the potential underlying mechanisms. MCM2 expression and prognostic significance were analyzed in TCGA-UCEC datasets. Combining
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RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Shengwei Zhuang, Weihong Lu, Lianjun Shen, Zhekun Huang, Xiuping Zhang, Yong Zhang
Colorectal cancer (CRC) is a malignant tumor with high morbidity and mortality. It is well-accepted that dysregulated lncRNAs are closely related to the development of CRC. In this study, the function and mechanism of RNASEH1-AS1 in CRC were investigated. RT-qPCR and western blot detected the expression of targeted genes in tissues and cells. CCK-8, clone formation, wound healing assay, and Transwell
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A pan-cancer analysis of RGR opsin expression and its downregulation associated with poor prognosis in glioma. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Jianglong Feng, Wei Zhang, Wen Zeng, Yu Wang, Yangguang Gu, Yinghua Lan, Wenxiu Yang, Hongguang Lu
Retinal G protein-coupled receptor (RGR) serves a retinal photoisomerase function to mediate retinoid metabolism and visual chromophore regeneration in the human eyes. Retinoids display critical functions in cell proliferation, differentiation, and apoptosis. Abnormal retinoid metabolism may contribute to tumor development. However, in human tumor tissues, the expression of RGR remains uncharacterized
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Brain metastasis from esophageal squamous cell carcinoma: a clinical review of 30 cases. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Yu Yang, Yang Yang, Xiuwei Wu, Nianfei Wang, Mingjun Zhang
This study aimed to retrospectively evaluate the treatment strategies and possible prognostic factors in patients with brain metastases (BMs) from esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed 30 patients with BMs from ESCC who were treated at our center between November 2011 and January 2022. Clinicopathological characteristics and clinical outcomes were analyzed. The median
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GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Jiming Chen, Yinhang Wu, Qing Zhou, Yifei Song, Jing Zhuang, Kongjie Lu, Xi Yang
High cholesterol is an important factor inducing colorectal cancer (CRC). The study aims to determine the key genes and regulatory mechanism associated with tumor-infiltrating T cells underlying cholesterol-induced CRC. Gene expression data and clinical data from CRCS in The Cancer Genome Atlas (TCGA) were selected for differential expression and survival analysis. A total of 5,815 DEGs and 21 cholesterol-associated
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ΔNp63 is regulated by insulin/IGF-1 signaling in normal basal/progenitor mammary cells and in luminal-type breast cancer cells. Neoplasma (IF 3.0) Pub Date : 2023-12-6 Michaela Stenckova, Yajing Liu, Marta Nekulova, Jitka Holcakova, Zuzana Pokorna, Rudolf Nenutil, Alastair M Thompson, Borivoj Vojtesek, Philip John Coates
Breast cancers are a heterogeneous group of tumors classified according to their histological growth patterns and receptor expression characteristics. Intratumor heterogeneity also exists, with subpopulations of cells with different phenotypes found in individual cancers, including cells with stem or progenitor cell properties. At least two types of breast cancer stem cells (CSCs) exist, the epithelial
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FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells. Neoplasma (IF 3.0) Pub Date : 2023-11-28 Yanghui Bi,Yanfang Yang,Yong Zhang,Caixia Cheng,Peisen Tang,Heng Xiao,Fajia Yuan,Weiwei Wu,Bin Yang
F-box and WD repeat domain containing 7 (FBXW7) is an aboriginal and high-frequency mutant gene associated with esophageal squamous cell carcinoma (ESCC). This study was designed to determine the clinical value and molecular mechanisms of FBXW7 in the development of ESCC. The clinical significance of FBXW7 was analyzed in ESCC from TCGA data. The effects of FBXW7 on proliferation, colony formation
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Tumor-derived autophagosome vaccines combined with immune adjuvants mediate antitumor immune responses via the neoantigen pathway. Neoplasma (IF 3.0) Pub Date : 2023-11-28 Jia Yuan,Yue Chang,Yalan Dai,Yutong Chen,Rongbin Yue,Linjuan Zeng
Vaccines composed of autophagosomes derived from tumor cells called DRibbles (DRips-containing blebs) are involved in the cross-presentation of tumor antigens, thus inducing cross-reactive T-cell responses against the tumor. Compared with traditional tumor lysate vaccines, autophagosome vaccines were found to be better sources of multiple tumor-associated antigens (TAAs) that activate antigen-specific
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The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway. Neoplasma (IF 3.0) Pub Date : 2023-11-15 Yongkun Wang,Yingchun Li,Cui Ran,Wenjun Le,Jiaxing Dong,Xujing Wang,Bo Chen,Xiaohua Jiang
Pancreatic cancer is one of the most lethal tumors due to its rapid proliferation and aggressiveness. RAD51AP1 is a protein-coding gene with critical functions in many cancers but few studies have assessed RAD51AP1 in pancreatic cancer. Bioinformatics methods and cell function experiments were performed to reveal the functions of RAD51AP1 in vitro. Gene Expression Profiling Interactive Analysis (GEPIA)
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miR-124 delivered by BM-MSCs-derived exosomes targets MCT1 of tumor-infiltrating Treg cells and improves ovarian cancer immunotherapy. Neoplasma (IF 3.0) Pub Date : 2023-11-15 Tian Gao,Yong-Qing Lin,Hai-Yan Ye,Wu-Mei Lin
Metabolic rewiring of tumor cells leads to an enrichment of lactate in the tumor microenvironment (TME). This lactate-rich environment of solid tumors has been reported to support tumor-infiltrating regulatory T (Treg) cells. Therefore, agents that modify lactate metabolism of Treg cells have therapeutic potential. Monocarboxylate transporter 1 (MCT1), which Treg cells predominantly express, plays
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Long noncoding RNA PVT1 predicts poor prognosis and promotes the progression of colorectal cancer through the miR-24-3p/NRP1 axis in zebrafish xenografts. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Hailin Yin, Shanye Gu, Guiqin Li, Hanxu Yu, Xishan Zhang, Yangsong Zuo
Long noncoding RNAs (lncRNAs) play important roles in the progression of human cancer. It is reported that lncRNA plasmacytoma variant translocation 1 (PVT1) is involved in colorectal cancer (CRC), however, the underlying mechanism remains to be explored deeply, especially by in vivo models. In the present study, bioinformatics analysis showed that the expression level of PVT1 was upregulated in CRC
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Migration-inducing gene-7 promotes glioma cell proliferation and invasiveness via activating the MAPK signaling pathway. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Zhigang Pan, Chunhui Chen, Xinyue Huang, Yu Xiong, Xiaodong Kang, Jianfeng Zhou, Xiumei Guo, Shuni Zheng, Cui'e Wang, Feng Zheng, Weipeng Hu
Glioma is a highly aggressive primary malignant tumor. Migration-inducing gene-7 (Mig-7) is closely related to tumor invasion and metastasis. However, the detailed molecular mechanism of Mig-7-mediated promotion of glioma cell invasion requires further investigation. Therefore, this study aimed to investigate the molecular mechanism by which Mig-7 promotes invasion and growth of glioma tumor cells
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Hydrogel-based miR-192 delivery inhibits the development of hepatocellular carcinoma by suppressing the GSK3β/Wnt/β-catenin pathway. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Qing Yang, Xiaojv Zhuge, Weili Lin, Weilai Yu, Yu Zhu, Changsheng Shi, Zhengchao Shi
Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by high invasiveness, metastasis, and poor prognosis, which lacks effective treatments. Although the role of miR-192 in HCC development has been recognized, the underlying molecular mechanism is still poorly understood. This study aimed to explore the impact of mir-192 on HCC and its potential as a therapeutic strategy. Wound healing
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Novel model of triple-negative breast cancer produces viable circulating tumor cells and rapid lung metastasis for functional testing in vivo. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Jana Plava, Lenka Trnkova, Peter Makovicky, Michal Mego, Svetlana Miklikova, Lucia Kucerova
Breast cancer metastases are the main reason for women´s highest cancer mortality. Even though tumor cell dissemination via circulating tumor cells (CTC) released from the primary site is a very ineffective process, distant metastases appear in 46% of triple-negative breast cancer (TNBC) patients corresponding to the disease aggressiveness. Laboratory models for functional testing which mimic the spread
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The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Vladimira Sadlonova, Alena Mazurakova, Lenka Koklesova, Nora Malinovska, Marian Grendar, Elena Novakova, Peter Kubatka
The purpose of this study was to assess the potential effects of Rhus coriaria L. (sumac) and of Cinnamomum zeylanicum L. bark on the selected serum cytokines as possible serum tumor markers - interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) in the rat model of mammary carcinogenesis. R. coriaria and C. zeylanicum bark were used as the chemopreventive-therapeutic agents
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miRNA-329-3p suppresses proliferation and metastasis of endometrial carcinoma through downregulating E2F1. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Ruicong Wang, Chen Zhang, Wanting Guan, Qing Yang
Existing evidences have revealed the crucial roles of E2 promoter binding factor-1 (E2F1) during the tumorigenesis and progression process of multiple human tumors. However, the expression patterns, biological functions, as well as the underlying molecular mechanism of E2F1 in endometrial carcinoma yet remain largely unclear. The expression patterns and clinical prognostic value of E2F1 in endometrial
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Camrelizumab combined with apatinib in the treatment of patients with hepatocellular carcinoma: a real-world assessment. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Dongbo Chen, Xiangxun Chen, Lei Xu, Yichun Wang, Liyang Zhu, Mei Kang
Although a phase II clinical trial confirmed that camrelizumab combined with apatinib is effective in patients with hepatocellular carcinoma (HCC), we generally lack data on the results of this regimen in real-world clinical practice. In this study, the efficacy and safety of camrelizumab combined with apatinib in the treatment of patients with HCC were re-evaluated. Data from 86 patients with HCC
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LncRNA HIF1A-AS2 mediates imatinib resistance by regulating autophagy in gastrointestinal stromal tumor cells. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Jingyi Yan, Xiaolei Chen, Ji Lin, Xuecheng Sun, Wei Chen
The aim of this study was to explore the role and mechanism of long non-coding RNA (lncRNA) HIF1A antisense RNA 2 (HIF1A-AS2) in regulating imatinib (IM) resistance in gastrointestinal stromal tumor (GIST) cells under hypoxia. The expression of HIF1A-AS2 was silenced by siRNA in GIST cells. Cytotoxicity, apoptosis, and autophagy were evaluated under normoxic and hypoxic conditions. The expression levels
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The effect of physical exercise and dairy probiotics (Lactobacillus casei) on gut microbiome in childhood cancer survivors. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Viktor Bielik, Ivan Hric, Sabína Šmahová, Miriam Tkačiková, Veronika Hlaváčová, Libuša Nechalová, Simona Ugrayová, Alexandra Kolenová
Gut microbial dysbiosis persists months after intensive cancer treatment in children and adolescents. This prospective study compared the intestinal microbiome of children 1-3 years after completion of Berlin-Frankfurt-Münster protocol (BFM)-based pediatric ALL (PALL) treatment and healthy controls. To induce a favorable shift in the bacterial composition of the intestines in PALL with gut microbiome
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Unraveling the complexity: A comprehensive analysis of the PP2A in cancer and its potential for novel targeted therapies. Neoplasma (IF 3.0) Pub Date : 2023-10-4 Danica Ivovič, Pavlína Kabelíková, Dana Jurkovičová
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase considered a potent tumor suppressor that critically regulates diverse cellular processes, including cell cycle progression, apoptosis, or DNA repair. PP2A is typically downregulated in cancers but mechanisms for its inactivation in human cancers are poorly understood. PP2A represents a family of more than 60 phosphatases. According
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Immunohistochemical p16 expression in the prognosis of patients with sinonasal squamous cell carcinoma. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Li Wang,Hua-Tao Quan,Jie Wang,Tian-Ci Tang,Yi Li,Xin-Mao Song
In sinonasal squamous cell carcinoma (SNSCC), the prognostic relevance of p16INK4a (p16) expression has been reported rarely. This study aims to examine the immunohistochemical expression of p16 and investigate the possibility of p16 as a prognostic factor for SNSCC. The medical records of 173 individuals with SNSCC between 2010 and 2022 were retrospectively reviewed. The researchers examined patients'
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Tumor-targeted suicide gene-directed enzyme prodrug therapy mediated by extracellular vesicles. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Jana Jakubechova,Ursula Altanerova,Cestmir Altaner
In this article, we describe the gene-directed enzyme prodrug therapy, also known as the "Trojan Horse" therapy mediated by exosomes - small extracellular vesicles (sEVs) secreted from mesenchymal stem/stromal cells (MSCs) and cancer cells. MSC-EVs possess strong migrating tropism toward tumor sites. EVs derived from tumor cells mimic the parental cells in an invasive metastatic growth trait and the
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What is the best time for postoperative radiation therapy in pN1 prostate cancer? Neoplasma (IF 3.0) Pub Date : 2023-06-01 Francesco Alessandro Mistretta,Stefano Luzzago,Giulia Marvaso,Giulia Corrao,Ilaria Sabatini,Matteo Fontana,Federico Mastroleo,Mattia Zaffaroni,Maria Giulia Vincini,Ettore Di Trapani,Gabriele Cozzi,Roberto Bianchi,Matteo Ferro,Ottavio de Cobelli,Barbara Alicja Jereczek-Fossa,Gennaro Musi
We retrospectively compared long-term biochemical recurrence rates (BCR) in pN1 PCa patients that underwent adjuvant radiotherapy (aRT) vs. no aRT/early salvage (esRT) after robot-assisted radical prostatectomy and extended pelvic lymphadenectomy. All PCa pN1 M0 patients treated at a single high-volume center between 2010 and 2020 were analyzed. Patients with <10 LNs yield, or >10 positive LNs, or
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Predictors of outcomes of docetaxel treatment in de novo metastatic hormone-sensitive prostate cancer: A single-center cohort study. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Tomislav Omrčen,Davor Eterović,Tea Jozić,Eduard Vrdoljak
Six cycles of docetaxel in addition to androgen deprivation therapy (ADT) are currently one of the treatment options for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC). Since the outcomes in patients with high-volume (HV) disease remain modest, we aimed to identify patients for more intensified treatment. We report a cohort of 73 consecutive patients with de novo mHSPC treated
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LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Fan-Lin Zeng,Jie Lin,Xing Xie,Yuan-Kang Xie,Jian-Hong Zhang,Daofeng Xu,Xiao He,Feng En Liu,Bin-Hui Xie
Hepatocellular carcinoma (HCC) is a malignant tumor, which seriously threatens the life of patients. LncRNA SLC7A11-AS1 was reported to be abnormally expressed in HCC. Here, the functions and relative molecular regulatory mechanism of SLC7A11-AS1 in HCC were investigated. Nude mice and HCC cells were used as the experimental subjects. Knockdown or overexpression of exogenous genes was conducted in
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Chemotherapy versus chemoradiotherapy in borderline resectable and locally advanced pancreatic adenocarcinoma. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Soňa Argalácsová,Michal Vočka,Luboš Petruželka,Miroslav Ryska,Pavel Záruba,Zdeněk Krška,Vladimír Frýba,Jan Ulrych,Vladimír Černý,Tomáš Tůma,David Hoskovec
The role of radiotherapy in borderline resectable (BRPC) and locally advanced pancreatic carcinoma (LAPC) remains controversial. In our study, we retrospectively evaluated 48 patients with BRPC (14; 29.2%) and LAPC (34; 70. 8%) who underwent 6-8 cycles of induction mFOLFIRINOX chemotherapy alone (23; 47.9%) or 4-6 cycles of mFOLFIRINOX followed by hypofractionated radiotherapy (up to the total dose
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Prognostic implications of the EGFR polymorphism rs763317 and clinical variables among young Chinese lung cancer population. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Zheng-Xing Li,Fan Wang,Zhen-Yu Sun,Chang Xu,Zi-Xiu Zou,Zong-Xu Zhao,Hai-Jian Wang,Shi-Cheng Guo,Li Jin,Qiang Li,Jiu-Cun Wang,Fan Xia,Xiao-Qiang Yue,Junjie Wu
The 5-year survival rate for patients with lung cancer, the world's second most frequent malignant tumor, is less than 20%, and its prognosis cannot be clearly predicted. Our aim was to analyze the epidermal growth factor receptor (EGFR) rs763317 (G>A) single nucleotide polymorphism and its association with prognosis in Chinese Han lung cancer patients. 839 patients with primary lung cancer were recruited
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Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Miroslav Tibensky,Filip Blasko,Peter Vargovic,Jana Jakubikova,Dana Cholujova,Jana Jakubechova,Boris Mravec
Experimental and clinical data have shown that the nervous system can significantly stimulate the initiation and progression of melanoma. In support of this, approaches that reduce the transmission of signals from peripheral nerves to effector tissues reduce the recurrence of melanoma. Therefore, we investigated the effect of topical application of the local anesthetic Pliaglis (7% lidocaine and 7%
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Function, drug resistance and prognostic effect of AKR1C2 in human cancer. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Zhao Wang,Yue Feng,Jiayu Song,Di Sun,Yun-Yan Zhang
Aldo-keto reductases (ARKs), a group of reductases that rely on nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) to catalyze carbonyl, are widely found in various organisms, which play an important role in the physiological and pathological processes of human. Aldo-keto reductase family 1 member C2 (AKR1C2) as a member of the human ARKs family, can regulate
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Functional consequences of altered glycosylation of tumor-associated hypoxia biomarker carbonic anhydrase IX. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Magdalena Baratova,Lucia Skvarkova,Maria Bartosova,Lenka Jelenska,Miriam Zatovicova,Barbora Puzderova,Ivana Kajanova,Lucia Csaderova,Silvia Pastorekova,Eliska Svastova
Glycosylation is a posttranslational modification of proteins affecting numerous cellular functions. A growing amount of evidence confirms that aberrant glycosylation is involved in pathophysiological processes, including tumor development and progression. Carbonic anhydrase IX (CAIX) is a transmembrane protein whose expression is strongly induced in hypoxic tumors, which makes it an attractive target
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Effects of different-sized silver nanoparticles on morphological and functional alterations in lung cancer and non-cancer lung cells. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Kristina Jakic,Michal Selc,Radka Macova,Antonia Kurillova,Libor Kvitek,Ales Panacek,Andrea Babelova
Silver nanoparticles (AgNPs) exhibit unique physicochemical properties, making these nanomaterials attractive for various medical applications. Among them, AgNPs have shown great potential in the treatment of cancer by inducing apoptosis in cancer cells, inhibiting tumor growth, and enhancing the efficacy of conventional cancer treatments such as chemotherapy and radiation therapy. Despite the promising
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NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Guo-Fang Sun,Hao Ding
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts. Among 15 m5C regulators (NSUN2, NSUN3, NSUN4, NSUN5, NSUN6,
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TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Sheng-Qi Sang,Yi-Jie Zhao,Meng Wang,Xiao-Qi Zhong,Zhi-Cheng Yang,Meng-Meng Lu
The regulation of protein kinase B (AKT) phosphorylation by Tripartite motif-containing protein 31 (TRIM31) is implicated as an essential mechanism in the progression of many malignant tumors. Nevertheless, the function of the TRIM31/AKT pathway in oral squamous cell carcinoma (OSCC) remains elusive. Here, immunohistochemistry analysis of human OSCC tissue microarrays indicated significantly higher
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A new pathway for the transformation of AML in MDS: APA mechanism regulated by NUDT21 and RUNX1. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Shuo Li,Fanggang Ren,Xiao-Li Liu,Hong-Yu Zhang,Zhi-Fang Xu,Daniel Muteb Muyey,Zhuanzhen Zheng,Yan-Hong Tan,Xiu-Hua Chen,Hong-Wei Wang
We have identified that NUDT21 plays a vital role in MDS transformations, while the transcription factor RUNX1 is essential for normal hematopoiesis, which is a high expression in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), and we aim to explore the linkage between the two genes and new pathways for MDS transformation to AML. Prediction of RUNX1 expression levels and its relationship
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Circular RNA_0000326 accelerates breast cancer development via modulation of the miR-9-3p/YAP1 axis. Neoplasma (IF 3.0) Pub Date : 2023-06-01 Xiao-Ling Xue,Shuai Zhao,Meng-Chang Xu,Ying Li,Wen-Fei Liu,Hong-Zhen Qin
Circular RNA (circ)_0000326 has been reported in bladder cancer and cervical cancer and is concerned to be involved with the development of cancerous cells. Whereas, there have been no reports concentrating on the influences of circ_0000326 in breast cancer (BC). Therefore, the latent modulatory mechanisms of circ_0000326 in BC are researched. circ_0000326 expression in BC tissues and correlative cells
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Urinary shedding of common DNA viruses and their possible association with bladder cancer: a qPCR-based study. Neoplasma (IF 3.0) Pub Date : 2023-5-25 Jan Hrbáček, Vítězslav Hanáček, Dominika Kadlečková, Adéla Cirbusová, Pavel Čermák, Ruth Tachezy, Roman Zachoval, Martina Saláková
After a decade of human urinary microbiota research, little is known about the composition of the urinary virome and its association with health and disease. This study aimed to investigate the presence of 10 common DNA viruses in human urine and their putative association with bladder cancer (BC). Catheterized urine samples were collected from patients undergoing endoscopic urological procedures under
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NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway. Neoplasma (IF 3.0) Pub Date : 2023-5-25 Liao-Liao Zhu, Jing-Jie Shi, Yong-Dong Guo, Cheng Yang, Rong-Lin Wang, Shan-Shan Li, Dong-Xue Gan, Pei-Xiang Ma, Jun-Qiang Li, Hai-Chuan Su
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is highly expressed in a variety of malignant tumors and functions as an oncogene; however, its role in colorectal cancer (CRC) remains unclear. We aimed to explore the function and regulatory mechanisms of NUCKS1 and potential therapeutic agents targeting NUCKS1 in CRC. We knocked down and overexpressed NUCKS1 in CRC cells
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The inhibition of Aurora A kinase regulates phospholipid remodeling by upregulating LPCAT1 in glioblastoma. Neoplasma (IF 3.0) Pub Date : 2023-5-25 Ya-Zhou Miao, Jing Wang, Shu-Yu Hao, Yu-Xuan Deng, Zhe Zhang, Ze-Ping Jin, Da-Yuan Liu, Shao-Dong Zhang, Hong Wan, Nan Ji, Jie Feng
Metabolic reprogramming is a common feature of glioblastoma (GBM) progression and metastasis. Altered lipid metabolism is one of the most prominent metabolic alterations in cancer. Understanding the links between phospholipid remodeling and GBM tumorigenesis may help develop new anticancer strategies and improve treatments to overcome drug resistance. We used metabolomic and transcriptomic analyses
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Cellular immunotherapy combined with platinum-based chemotherapy prolongs survival for non-small cell lung cancer patients. Neoplasma (IF 3.0) Pub Date : 2023-03-30 Lei Qian,Xiao Ding,Fang-Qi Li,Hui-Min Tian,Xiao Chen,Fu-Jun Han,Hong-Yi Wang,Wen-Qian Li,Chao Niu,Jian-Ting Xu,Zhao-Zhi Li,Hua He,Jiu-Wei Cui
Platinum-based chemotherapy is the primary treatment option for advanced non-small cell lung cancer (NSCLC) patients without a driver gene mutation, but its efficacy is still modest. Through a potential synergistic effect, autologous cellular immunotherapy (CIT) composed of cytokine-induced killer (CIK), natural killer (NK), and T cells might enhance it. NK cells exhibited in vitro cytotoxicity toward
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Transcriptional adaptor 3 influences the proliferative and invasive phenotypes of non-small cell lung cancer cells via regulating EMT. Neoplasma (IF 3.0) Pub Date : 2023-03-30 Li-Qin Xu,Shu-Wen Zhang,Rui Zhang,Jing-Jing Chen,Zai-Xin Yuan,Jian Feng,Jian-An Huang
Transcriptional adaptor 3 (TADA3/ADA3) is a conserved transcriptional co-activator and is dysregulated in many aggressive tumors. However, the role of TADA3 in non-small cell lung cancer (NSCLC) remains unknown. It was previously demonstrated that TADA3 expression correlates with poor prognosis in patients with NSCLC. In the present study, the expression and function of TADA3 were investigated in cells
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Hypoxia-induced miR-9 expression promotes ovarian cancer progression via activating PI3K/AKT/mTOR/GSK3β signaling pathway. Neoplasma (IF 3.0) Pub Date : 2023-03-24 Wen-Jing Zhu, Huan-Huan Huang, Yi-Fan Feng, Lei Zhan, Jian Yang, Lin Zhu, Qing-Yuan Wang, Bing Wei, Wen-Yan Wang
Ovarian cancer (OC) is one of the most prevalent malignant tumors affecting women's life and health. Since OC has a poor prognosis due to extensive metastasis, there is a need to explore a new mechanism of OC metastasis. microRNAs (miR) are single-stranded, non-coding RNAs. miR-9 has been reported to promote cancer and may provide a new strategy for OC diagnosis. The purpose of this study was to examine
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High expression of WTAP is related to poor prognosis in nasopharyngeal carcinoma. Neoplasma (IF 3.0) Pub Date : 2023-03-24 Chang-Juan Tao, Peng Zhang, Yuan-Yuan Chen, Ming Chen
Wilms' tumor 1-associated protein (WTAP), a component of the m6A methyltransferase complex, recruits the m6A methyltransferases METTL3 and METTL14 to the corresponding mRNA targets to participate in the formation of N6-methyladenosine. However, the molecular mechanism of WTAP in the tumorigenesis and progression of nasopharyngeal carcinoma (NPC) remains unclear. This study aimed to explore the prognostic
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Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1. Neoplasma (IF 3.0) Pub Date : 2023-3-15 Yun-Zhi Dang, Xiao-Jiao Chen, Jiao Yu, Shu-Hong Zhao, Xi-Ming Cao, Qing Wang
Since metastasis remains the primary reason for colorectal cancer (CRC) associated death, a better understanding of the molecular mechanism underlying CRC metastasis is urgently needed. Here, we elucidated the role of Cathepsin C (CTSC) in promoting CRC metastasis. The expression of CTSC was detected by real-time PCR and immunohistochemistry in the human CRC cohort. The metastatic capacities of CTSC-mediated
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GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3β/EMT axis. Neoplasma (IF 3.0) Pub Date : 2023-3-15 Zonglei Mao, Yong Wu, Pingan Yao, Chungen Xing
GOLM1 (Golgi membrane protein 1), a key tumor progression- and metastasis-related marker, is highly expressed in a variety of epithelium-derived human cancers. However, its expression and functions in human colorectal cancer (CRC) have been rarely explored. The present study verified the high expression of GOLM1 within CRC tissues and cell lines. GOLM1 was positively correlated with vascular invasion
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Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12. Neoplasma (IF 3.0) Pub Date : 2023-3-15 Xiao-Peng Li, Yun-Long Jia, Yu-Qing Duan, Yan Zhao, Xiao-Lei Yin, Shu-Man Zhen, Yi Zhang, Li-Hua Liu
Growing evidence has indicated that circular RNAs (circRNAs) play crucial roles in the tumorigenesis and progression of diverse malignancies. However, the majority of circRNAs involved in esophageal squamous cell carcinoma (ESCC) remain undefined and the exact functions and underlying mechanisms of circRNAs in ESCC still need further exploration. In this study, we identified a novel onco-circRNA hsa_circ_0002938
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Correction: lncRNA PSMB8-AS1 promotes colorectal cancer progression through sponging miR-1299 to upregulate ADAMTS5. Neoplasma (IF 3.0) Pub Date : 2023-3-15 Fang Zhao, Meng Wang, Yibin Zhang, Rujuan Su, Chenyang He, Xiao Gao, Ying Zan, Shuqun Zhang, Yuguang Ma
This corrects the article DOI: 10.4149/neo_2022_220111N42.