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Diffuse Infiltrating Retinoblastoma with Anterior Chamber Involvement: Conservative Management and Identification of RB1 Alterations in Aqueous Humor. Ocul. Oncol. Pathol. Pub Date : 2023-06-16 Nathalie Cassoux,Denis Malaise,Livia Lumbroso-Le-Rouic,Jessica Le Gall,Lisa Golmard,Liesbeth Cardoen,Paul Freneaux,Yassine Bouchoucha,Isabelle Aerts,François Doz,Alexandre Matet
Introduction The aim of the study was to describe the successful conservative management of diffuse infiltrating retinoblastoma (DIR). Identification of RB1 pathogenic variant was done after cell-free DNA (cfDNA) analysis in aqueous humor. Case presentation Herein, we report 2 patients with unilateral, non-familial DIR with anterior and posterior involvement. Both patients underwent liquid biopsy for
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Can Enhancement Pattern in Normal-Sized Optic Nerves on Magnetic Resonance Imaging Better Predict Tumor Invasion in Retinoblastoma Eyes? Ocul. Oncol. Pathol. Pub Date : 2023-06-02 Madhu Chiranthan,Rachna Meel,Sanjay Sharma,Neiwete Lomi,Seema Kashyap,Mandeep S Bajaj
Introduction Optic nerve (ON) enhancement alone without ON thickening on contrast-enhanced magnetic resonance imaging (CE-MRI) can be associated with post-laminar optic nerve invasion (PLONI) in eyes with group E retinoblastoma. A few case reports and retrospective studies in the literature show a poor correlation between ON enhancement on MRI and ON invasion on histopathological examination (HPE)
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The 5th edition of the World Health Organization Classification of Tumours of the Eye and Orbit Ocul. Oncol. Pathol. Pub Date : 2023-04-18 Tatyana Milman, Hans E Grossniklaus, Gabrielle Goldman-Levy, Tero T Kivelä, Sarah E Coupland, Valerie A White, Hardeep Singh Mudhar, Charles G Eberhart, Robert M Verdijk, Steffen Heegaard, Anthony J Gill, Martine J Jager, Aberlardo A Rodriguez-Reyes, Bita Esmaeli, Jennelle C Hodge, Ian A Cree
The 5th edition of the World Health Organization (WHO) Classification of Tumours of the Eye and Orbit is the latest step in standardizing the diagnostic practice worldwide. Building upon the 4th edition, published in 2018, the 5th edition introduces new chapters on the eyelid and orbital tumors, and consolidates sections on hematolymphoid tumors, soft tissue and bone tumors, metastases and genetic
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Is tumour thickness measurement required for MOLES scoring of melanocytic choroidal tumours? Ocul. Oncol. Pathol. Pub Date : 2023-04-10 Jared Ching, Lamis AlHarby, Mandeep S. Sagoo, Bertil Damato
Introduction: It can be challenging to distinguish between choroidal naevi and melanomas in the community setting, particularly without access to ultrasonography, required to measure the thickness of melanocytic choroidal tumours. We aimed to determine whether thickness measurement is required for MOLES scoring of melanocytic choroidal tumours. Methods: The dataset of a recent MOLES evaluation was
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Primary Subretinal Seeding in Retinoblastoma: Clinical Presentation and Treatment Outcomes Ocul. Oncol. Pathol. Pub Date : 2023-04-10 Komal Bakal, Vishal R Raval, Sai Krishna Gattu, Vijay Anand Reddy Palkonda, Swathi Kaliki
Purpose: To describe the clinical features and treatment outcomes of primary subretinal seeds (SRS) in patients with intraocular retinoblastoma (RB). Methods: Descriptive analysis of primary SRS in 47 patients (50 eyes) with RB. Results: Mean age was 19 months (range, 2–72 months) and 55% (n=26) of the subjects were male. At presentation, the SRS involved two or more quadrants in 88% of eyes. Most
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Dendritic Melanocytic Hyperplasia in Pterygia- A Potential Source of Diagnostic Confusion with Primary Acquired Melanosis Ocul. Oncol. Pathol. Pub Date : 2023-04-07 Angela Oh, Ben Glasgow
Purpose: To report the nearly ubiquitous prevalence of melanocytic hyperplasia in benign pterygia/pingueculae and establish that is insufficiently recognized. Methods: This is a retrospective immunohistochemical pathology case series of 30 consecutive pterygia/pingueculae samples selected from an ophthalmic pathology database at a single institution. Histopathologic and immunohistochemistry analyses
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Ultrasound verification of plaque brachytherapy placement in patients treated for primary uveal melanoma: a single-center experience Ocul. Oncol. Pathol. Pub Date : 2023-03-14
Introduction: Proper plaque positioning is essential for effective episcleral plaque brachytherapy and can be verified using ultrasound. In this study, we show our center’s protocol for intraoperative ultrasound verification of plaque placement and present our single-center local recurrence data in patients with primary UM involving the choroid and/or ciliary body. We also indicate our center’s distance
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Ultrasound verification of plaque brachytherapy placement in patients treated for primary uveal melanoma: a single-center experience Ocul. Oncol. Pathol. Pub Date : 2023-03-14
Introduction: Proper plaque positioning is essential for effective episcleral plaque brachytherapy and can be verified using ultrasound. In this study, we show our center’s protocol for intraoperative ultrasound verification of plaque placement and present our single-center local recurrence data in patients with primary UM involving the choroid and/or ciliary body. We also indicate our center’s distance
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Acknowledgement to Reviewers Ocul. Oncol. Pathol. Pub Date : 2023-02-16
Ocul Oncol Pathol 2022;8:250
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Acknowledgement to Reviewers Ocul. Oncol. Pathol. Pub Date : 2023-02-16
Ocul Oncol Pathol 2022;8:250
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Tissue Glue Adhesion for Plaque Radiotherapy of Uveal Melanoma in Humans, an Initial Experience Ocul. Oncol. Pathol. Pub Date : 2023-02-09 Kushal U. Agrawal, Nicholas E. Kalafatis, Konica Singla, Sara E. Lally, Carol L. Shields
Purpose: To study use of tissue glue instead of conventional suturing, to secure I-125 plaque in human eyes with uveal melanoma. Methods: We studied six patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intra-operatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque surface. The plaque was held
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Tissue Glue Adhesion for Plaque Radiotherapy of Uveal Melanoma in Humans: An Initial Experience Ocul. Oncol. Pathol. Pub Date : 2023-02-09
Purpose: The aims of this study were to study use of tissue glue instead of conventional suturing and to secure I-125 plaque in human eyes with uveal melanoma. Methods: We studied 6 patients with choroidal melanoma undergoing plaque radiotherapy who were found to have thin sclera intraoperatively. Following tumor localization and plaque placement, tissue glue was applied over and around the plaque
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Response to Cook and Alsina’s Letter to Editor Ocul. Oncol. Pathol. Pub Date : 2023-02-08 James J. Augsburger, Cassandra C. Skinner, Zelia Correa
It is a letter and does not have abstract.
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Mitogen-Activated Pathway Kinase (MAPK) Inhibitor-Associated Retinopathy: Do features differ with upstream versus down-stream inhibition? Ocul. Oncol. Pathol. Pub Date : 2023-02-08
Introduction Many cancers have derangement of the Mitogen-Activated Pathway Kinase (MAPK) making this pathway blockade a therapeutic target. However, inhibitors of MAPK can result in adverse effects including retinopathy. This study compares clinical and morphologic characteristics of serous retinal disturbances in patients taking agents with variable inhibition of MAPK: either direct interference
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Response to Cook and Alsina’s Letter to Editor (Reply to Augsburger et al.) Ocul. Oncol. Pathol. Pub Date : 2023-02-08
Ocul Oncol Pathol
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Mitogen-Activated Pathway Kinase (MAPK) Inhibitor-Associated Retinopathy: Do features differ with upstream versus down-stream inhibition? Ocul. Oncol. Pathol. Pub Date : 2023-02-08
Introduction Many cancers have derangement of the Mitogen-Activated Pathway Kinase (MAPK) making this pathway blockade a therapeutic target. However, inhibitors of MAPK can result in adverse effects including retinopathy. This study compares clinical and morphologic characteristics of serous retinal disturbances in patients taking agents with variable inhibition of MAPK: either direct interference
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Reply to Augsburger et al— Selection bias may impact reported metastasis risk for 15-gene expression profile Class 1A/B patients Ocul. Oncol. Pathol. Pub Date : 2023-02-07 Robert W. Cook, Katherina M. Alsina
N/A
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Angiographic Features of Iris Melanocytic Tumors: Nevus vs. Melanoma Ocul. Oncol. Pathol. Pub Date : 2023-01-13 Janani Singaravelu, Alexander Melendez-Moreno, Jacquelyn Wrenn, Arun D. Singh
Introduction: Determining the nature of iris melanocytic tumors based on clinical exam alone remains challenging. Tumor associated vasculature of iris melanocytic lesions may facilitate ability to discern between iris nevus and melanoma. Methods: In a single-institution, retrospective, observational study of 45 patients with pathologically confirmed iris melanoma and 15 patients with iris nevi that
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Angiographic Features of Iris Melanocytic Tumors: Nevus vs. Melanoma Ocul. Oncol. Pathol. Pub Date : 2023-01-13
Introduction: Determining the nature of iris melanocytic tumors based on clinical exam alone remains challenging. Tumor associated vasculature of iris melanocytic lesions may facilitate ability to discern between iris nevus and melanoma. Methods: In a single-institution, retrospective, observational study of 45 patients with pathologically confirmed iris melanoma and 15 patients with iris nevi that
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Peripheral Hemorrhagic Chorioretinopathy (PEHCR): Differentiating Features from Choroidal Melanoma Ocul. Oncol. Pathol. Pub Date : 2022-12-14 Guneet S Sodhi, Nakul Singh, Jacquelyn Wrenn, Arun D. Singh
Purpose: To identify non-overlapping diagnostic features between peripheral exudative hemorrhagic chorioretinopathy (PEHCR) and choroidal melanoma. Methods: A retrospective study of 80 patients (80 eyes); 40 patients (40 eyes) with PEHCR and 40 patients (40 eyes) with choroidal melanoma was conducted. Ophthalmoscopic and imaging features of PEHCR and choroidal melanoma were compared. Sensitivity and
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Peripheral Hemorrhagic Chorioretinopathy: Differentiating Features from Choroidal Melanoma Ocul. Oncol. Pathol. Pub Date : 2022-12-14
Introduction: Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is one of the leading mimickers of choroidal melanoma because of overlapping features with choroidal melanoma that make the distinction between these two entities difficult. Methods: To identify nonoverlapping diagnostic features between PEHCR and choroidal melanoma, a retrospective study of 80 patients (80 eyes); 40 patients
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Solitary metastases presentation from uveal melanoma: report of three cases and a comprehensive review of the literature. Ocul. Oncol. Pathol. Pub Date : 2022-11-10 Patrícia M. Pereira, Ana Luís, Maria José Passos, Emanuel Gouveia
Introduction: Uveal melanoma (UM) is a rare condition accounting for only 5% of all primary melanoma cases. Still, it is the most frequently diagnosed primary intraocular malignant tumor in adults. UM is an aggressive malignancy that originates from melanocytes in the eye. UMs are usually initiated by a mutation in GNAQ or GNA11, and rarely harbor a BRAF or NRAS mutations like cutaneous melanomas.
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Solitary Metastases Presentation from Uveal Melanoma: Report of 3 Cases and a Comprehensive Review of the Literature Ocul. Oncol. Pathol. Pub Date : 2022-11-10
Introduction: Uveal melanoma (UM) is a rare condition accounting for only 5% of all primary melanoma cases. Still, it is the most frequently diagnosed primary intraocular malignant tumor in adults. UM is an aggressive malignancy that originates from melanocytes in the eye. UMs are usually initiated by a mutation in GNAQ or GNA11, and rarely harbor a BRAF or NRAS mutations like cutaneous melanomas.
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Local recurrence in choroidal melanomas following Robotic assisted Radiosurgery (CyberKnife) Ocul. Oncol. Pathol. Pub Date : 2022-11-07 Valerie Schmelter, Frederick Schneider, Stefanie R. Guenther, Christoph Fuerweger, Alexander Muacevic, Siegfried G. Priglinger, Raffael Liegl, Paul Foerster
Background: Tumor recurrence in choroidal melanoma has been associated with decreased overall survival due to metastatic spreading. To detect risk factors of local recurrence and side effects, we analyzed tumor planning and treatment parameters in patients with recurrence of choroidal melanoma after treatment with robotic-assisted radiosurgery (CyberKnife). Methods: 694 patients treated with CyberKnife
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Serous Choroidal Detachment and Scleritis Associated with Necrotic Choroidal Tumors Ocul. Oncol. Pathol. Pub Date : 2022-11-04 Jared J. Ebert, Maura Di Nicola, Eric D. Hansen, Sean M. Collon, Matthew C. Hagen, Basil K. Williams Jr.
Purpose: To describe choroidal detachments and concurrent scleritis associated with necrotic choroidal metastasis or melanoma. Methods: Retrospective case series. Results: We report four patients with scleritis and choroidal detachment, with an underlying malignant choroidal tumor. All patients underwent fine-needle aspiration biopsy for cytopathologic characterization of their choroidal tumor, and
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Anterior Uveal Melanocytoma: Role of Diagnostic FNAB Ocul. Oncol. Pathol. Pub Date : 2022-10-19 Alexander Melendez-Moreno, Janani Singaravelu, Jennifer Brainard, Jacquelyn M. Davanzo, Arun D. Singh
Purpose: Anterior uveal melanocytomas (AUM) pose a diagnostic challenge as they can mimic growing melanomas. Establishing a definitive diagnosis of melanocytoma necessitates cytologic or histopathologic confirmation. We describe the clinical presentation and characteristics of fifteen pathologically proven AUM and assess the role of fine needle aspiration biopsy (FNAB) as a safe and effective tool
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A Case Series of Aggressive Orbital Plasmacytomas Ocul. Oncol. Pathol. Pub Date : 2022-10-12 Nizma Permaisuari, Neni Anggraini, Mutmainah Mahyuddin, Evelina Kodrat, Wulyo Rajabto
Introduction Orbital plasmacytoma is a tumor of plasma cells located in the orbit, which is uncommon and only accounts for less than 1% of total orbital tumors. We identified two aggressive orbital plasmacytoma cases. Case Presentations Two cases include 41-year-old woman and 45-year-old-man. Both initial complaints were unilateral rapid onset of non-axial proptosis with palpable mass at superior orbit
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Recurrence of primary acquired melanosis and conjunctival intraepithelial neoplasia. Ocul. Oncol. Pathol. Pub Date : 2022-09-14 Karin Svedberg
Introduction The aim of this study was to investigate the frequency of recurrences, time to recurrence and which patients had a recurrence after treatment of conjunctival intraepithelial neoplasia (CIN), carcinoma in situ, and primary acquired melanosis (PAM) with atypia. Methods A retrospective chart review of all patients included in the follow up program after completion of treatment for CIN or
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Uveitic Granulomas Masquerading as Ocular Tumors Ocul. Oncol. Pathol. Pub Date : 2022-09-01 Abdulrahman AlZaid, Moustafa S Magliyah, Yahya AlZahrani, Hani Basher AlBalawi, Hassan AlDhibi
Introduction: Solitary uveal lesions confer a diagnostic challenge to ophthalmologists. Uveitic lesions most abundantly appear amelanotic and commonly involve the choroid. Most amelanotic choroidal lesions are either neoplastic or inflammatory in origin. In our study, we aimed to describe six uveitic granuloma cases, which were referred to a tertiary ophthalmology center as intraocular tumors. Methods:
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Outcomes of second line intravitreal anti-VEGF switch therapy in radiation retinopathy secondary to uveal melanoma: moving from bevacizumab to aflibercept Ocul. Oncol. Pathol. Pub Date : 2022-09-01 Ojas Srivastava, Ezekiel Weis
Introduction: Radiation retinopathy is a dose-dependent complication of the retina following exposure to ionizing radiation. The objective of this prospective case-series is to determine the clinical efficacy of intravitreal aflibercept for radiation retinopathy secondary to radiotherapy for uveal melanoma in those that failed intravitreal bevacizumab treatment. Methods: A case-series of thirty patients
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Comparative Metastatic Rates in GEP Class 1A versus 1B Posterior Uveal Melanoma. Results Contrary to Expectations. Ocul. Oncol. Pathol. Pub Date : 2022-08-31 James J. Augsburger, Cassandra C. Skinner, Zelia M. Correa
Purpose: The purpose of this study was to determine whether the metastatic rates in patients with gene expression profile (GEP) class 1A versus 1B posterior uveal malignant melanoma supported or contradicted predictions of very low metastatic rate in GEP 1A cases and moderate rate in GEP 1B cases. Patients/Methods: 164 patients with a cytopathologically-confirmed primary posterior uveal malignant melanoma
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Predictors of Local Recurrence and Progression-Free Survival in Iodine-125 brachytherapy-treated Uveal Melanomas: A modern institutional study Ocul. Oncol. Pathol. Pub Date : 2022-08-29 Aaron A. Gurayah, Vanessa A. Peters, William Jin, Karthik Kalahasty, Deukwoo Kwon, Wei Zhao, Nirav V. Patel, Arnold M. Markoe, Zelia M. Correa, Matthew T. Studenski, J. William Harbour, Stuart E. Samuels
Introduction: Iodine-125 brachytherapy is an effective eye-sparing treatment for uveal melanoma. Previous work has shown that uveal melanomas cluster into distinct molecular classes based on gene expression profiles—discriminating low-grade from high-grade tumors. Our objective was to identify clinical and molecular predictors of local recurrence (LR) and progression-free survival (PFS). Methods: We
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Post-Brachytherapy Pigment Dispersion in Uveal Melanoma Ocul. Oncol. Pathol. Pub Date : 2022-07-22 Mahesh Palanivelu Shanmugam, Shwetha Suryakanth, Rajesh Ramanjulu, Divyansh Kailash Chandra Mishra
No structured abstract required for letter
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Clinicopathological Presentation of Retinoblastoma in Ethiopia Ocul. Oncol. Pathol. Pub Date : 2022-07-04 Sadik Taju Sherief, Daniel Getaneh Mulatu, Fran Wu, Jacquelyn O'Banion, Helen Dimaras
Objective : To describe the clinical and histopathologic characteristics of retinoblastoma among Ethiopian patients. Design: A hospital-based cross-sectional study. Methods: All children newly diagnosed with retinoblastoma during the study period of May 2015 to December 2019, inclusive, who presented to a tertiary referral center during were included. Demographic, clinical and histologic characteristics
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Comparison of Tumor Size and Gene Expression at Presentation in Uveal Melanoma Patients Before and During the COVID-19 Pandemic Ocul. Oncol. Pathol. Pub Date : 2022-05-09 Naomi Hasegawa, Alexander Rusakevich, Eric Bernicker, Bin S. Teh, Amy Schefler
Introduction: To compare the clinical and gene expression variables of uveal melanoma patients presenting before and after the start of the COVID-19 pandemic as surrogate markers in order to assess pandemic’s potential impact on care. Methods: We conducted a retrospective chart review of uveal melanoma patients at Retina Consultants of Texas and assessed tumor size, staging, and gene expression data
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Emerging New Therapeutics for Retinoblastoma Ocul. Oncol. Pathol. Pub Date : 2022-05-09 Vishal Raval, Manoj Parulekar, Arun D. Singh
Background: Over the last few decades, chemotherapy has become the main treatment of retinoblastoma, delivered through various routes: intravenous (IVC), intra-arterial (IAC), and intravitreal (IvitC). Despite its efficacy, chemotherapy related toxicity (ocular and systemic) and recurrences due to resistant tumor clones are common, highlighting the need for novel therapeutic agents. Summary: Recent
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Long term results after intraocular surgery in treated retinoblastoma eyes Ocul. Oncol. Pathol. Pub Date : 2022-04-20 Philipp Rating, Norbert Bornfeld, Sabrina Schlüter, Henrike Westekemper, Tobias Kiefer, Martin Stuschke, Sophia Göricke, Petra Ketteler, Saskia Ting, Klaus A. Metz, Nikolaos E. Bechrakis, Eva Biewald
Introduction: To analyze the results of intraocular surgery in treated retinoblastoma eyes and to assess the long-term results with a priority on local recurrences, secondary enucleation and metastases. Methods: Retrospective noncomparative case series. Results: From March 1964 to January 2020, 43 eyes of 40 retinoblastoma patients underwent intraocular surgery. Time interval between last therapy and
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Intraocular Lens and Lens Capsule Spread of Iridociliary Melanoma: Clinical and Histopathologic Features of 2 Cases Ocul. Oncol. Pathol. Pub Date : 2022-03-28 Corrina P. Azarcon, Jill R. Wells, Thomas Aaberg, Hans E. Grossniklaus
Purpose: To describe two patients with intraocular lens (IOL) and lens capsule spread of iridociliary melanoma. Methods: Two pseudophakic patients with iridociliary body melanoma that spread onto the surface of their IOL and remaining lens capsule were included. Their eyes were enucleated and the histopathologic features were evaluated. Results: Case 1 was an 82-year-old woman with diffuse primary
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PReferentially expressed Antigen in MElanoma (PRAME) Immunohistochemistry Labeling in Uveal Melanomas Ocul. Oncol. Pathol. Pub Date : 2022-03-11 Saman S. Ahmadian, Ian J. Dryden, Andrea Naranjo, Angus Toland, Romain A. Cayrol, Donald E. Born, Peter S. Egbert, Ryanne A. Brown, Prithvi Mruthyunjaya, Jonathan H. Lin
Introduction: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and despite treatment of the primary tumor, approximately 15-50% of patients will develop metastatic disease. Based on gene expression profiles (GEP), UM can be categorized as Class 1A (low metastatic risk), Class 1B (intermediate metastatic risk), or Class 2 (high metastatic risk). PRAME (PReferentially
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Unilateral Multifocal Choroidal Melanoma with Underlying Isolated Choroidal Melanocytosis Ocul. Oncol. Pathol. Pub Date : 2022-02-28 Maura Di Nicola, Jared J. Ebert, Matthew C. Hagen, James J. Augsburger, Basil K. Williams Jr.
Isolated choroidal melanocytosis is a rare condition that appears to be a limited form of ocular melanocytosis. Ocular melanocytosis has been known to be associated with an increased risk of uveal melanoma, and more recently a similar association has been suggested for isolated choroidal melanocytosis. We describe three cases of patients who developed unilateral, multifocal uveal melanoma in the setting
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Adjunctive treatment with Interferon-alpha 2b in conjunctival melanoma Ocul. Oncol. Pathol. Pub Date : 2022-01-27 Valentín Huerva, Pau Cid-Bertomeu, Ramón Espinet, Luisa M. Canto
Purpose: To demonstrate the clinical outcomes after resection of conjunctival melanoma (CM) followed by topical Interferon (IFN) alpha 2b after a long follow-up. Methods: Two consecutive CM patients were treated using tumor excision followed by topical IFN alpha 2b (1.000.000 UI/ml) four times a day for 12 weeks. The second case presented positivity due to the presence of tumor cells in the lower margin
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The histopathology of two eyes enucleated after continuous transscleral and micropulse transscleral cyclophotocoagulation for refractory secondary glaucoma Ocul. Oncol. Pathol. Pub Date : 2022-01-24 Imani M. Williams, Vamsee K. Neerukonda, Anna M. Stagner
Abstract: Introduction: Cyclodestructive procedures, which target the nonpigmented epithelium of the ciliary body, have been utilized to treat recalcitrant glaucoma since the early 1930’s. There are now various types of cyclophotocoagulation (CPC) available. The authors provide a retrospective description that details the histopathologic findings in 2 patients who underwent CPC for uncontrolled uveitic
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Correlation Between Frozen Section and Permanent Histopathologic Diagnoses in Adult Orbital Lesions Ocul. Oncol. Pathol. Pub Date : 2022-01-17 Sarah E. Eichinger, Hans Barron Heymann, Michael Mbagwu, Alexander Knezevic, Paul J. Bryar
Introduction: When indicated, the intraoperative use of frozen sections may assist in determining the surgical course or appropriate processing of surgical specimens. Knowing the accuracy of a preliminary frozen section diagnosis is important. The purpose of this study is to determine the rate of correlation between frozen and permanent histopathologic diagnosis for adult orbital lesions, analyze characteristics
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A Prediction Model to Discriminate Small Choroidal Melanoma from Choroidal Nevus Ocul. Oncol. Pathol. Pub Date : 2021-12-22 Emily C. Zabor, Vishal Raval, Shiming Luo, David E. Pelayes, Arun D. Singh
Objective: To develop a validated machine learning model to diagnose small choroidal melanoma. Design: Cohort study Subjects, Participants, and/or Controls: The training data included 123 patients diagnosed as small choroidal melanocytic tumor (5.0-16.0 mm in largest basal diameter and 1.0 mm to 2.5 mm in height; Collaborative Ocular Melanoma Study criteria). Those diagnosed as melanoma (n=61) had
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Impact of educational nursing intervention on compression therapy adherence and recurrence of venous leg ulcers: a quasi-experimental study Ocul. Oncol. Pathol. Pub Date : 2021-12-16 Amoura Soliman Behairy, Samah E. Masry
Following the healing of venous leg ulcers, the primary problems for nursing and patients are adhering to compression therapy and preventing ulcer recurrence. As a result, it is important that patients comprehend their situation. The purpose of this study is to see how an educational nursing intervention affected compression therapy adherence and recurrence of venous leg ulcers in patients with chronic
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Combination of brachytherapy and intravitreal chemotherapy in the treatment of retinoblastoma with vitreous seeding Ocul. Oncol. Pathol. Pub Date : 2021-11-30 Sabrina Schlüter, Norbert Bornfeld, Elbrus Valiyev, Dirk Flühs, Martin Stuschke, Nikolaos E. Bechrakis, Tobias Kiefer, Petra Ketteler, Sophia Göricke, Eva M. Biewald
Purpose: To report the efficacy of combined intravitreal chemotherapy (IVC) and ruthenium-106 brachytherapy in retinoblastoma, either as first line or second line treatment following systemic chemoreduction or intraarterial chemotherapy. Methods: Retrospective data collection of 18 eyes from 18 patients treated with IVC and brachytherapy from August 2014 to December 2019. Results: The method described
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Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review Ocul. Oncol. Pathol. Pub Date : 2021-11-23 Ahmad Abdel-Aty, Wendy L. Linderman, Ninani Kombo, John Sinard, Renelle Pointdujour-Lim
Background: Uveal melanoma is the most common primary intraocular malignancy in adults, often resulting in painless vision loss. We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and tabulation of reported cases. Summary: Our review found 44 published reports of spontaneously necrotic uveal
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Clinical applications of OCTA in ocular oncology: pearls and pitfalls Ocul. Oncol. Pathol. Pub Date : 2021-11-17 Marco Pellegrini, Giovanni Staurenghi, Chiara Preziosa
Background: Optical Coherence Tomography Angiography (OCTA) is a valuable imaging tool for the diagnosis of several retinal and choroidal diseases. Its role in ocular oncology is clinically promising but still controversial. In this review we report the main applications and limits of the use of OCTA for the study of intraocular tumors. Summary: OCTA allows a rapid, safe, low-cost and high-resolution
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Single time frame overview of the genetic changes in conjunctival melanoma from, intraepithelial disease to invasive melanoma. A study of 4 exenteration specimens illustrating the potential role of Cyclin D1. Ocul. Oncol. Pathol. Pub Date : 2021-11-17 Hardeep Singh Mudhar, Sachin S. Salvi, Daniel Pissaloux, Arnaud de La Fouchardiere
Abstract Introduction: Despite advances in the understanding of the molecular pathogenesis of cutaneous melanoma, relatively little is known about the genetic changes that occur in the progression of conjunctival melanocytic from intraepithelial lesions to invasive conjunctival melanoma. Methods: We exposed four exenteration specimens that each contained varying grades of intraepithelial conjunctival
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BAP1 Immunostain Status in Intraocular Biopsy Specimens for Uveal Melanoma Highly Correlates with Other Prognostic Markers Ocul. Oncol. Pathol. Pub Date : 2021-11-15 Cristiane M. Ida, Jose Pulido, Patricia T. Greipp, Joaquin J. Garcia, Timothy W. Olsen, Lauren Dalvin, Diva Regina Salomão
Introduction: Loss of BAP1 protein expression emerged as a negative prognostic marker in uveal melanoma (UM) and has primarily been studied in enucleations. Intraocular biopsy is frequently performed prior to UM globe-conserving therapy. Methods: We retrospectively evaluated BAP1 immunostaining of UM in 16 biopsies and 8 subsequent enucleations, and results were correlated with the UM-specific gene
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Impact of adjuvant ocular interventions on the quality of life of patients with uveal melanoma after proton beam therapy Ocul. Oncol. Pathol. Pub Date : 2021-11-08 Johannes Gollrad, Christopher Rabsahl, Antonia M Joussen, Andrea Stroux, Volker Budach, Dirk Boehmer, Alexander Böker
Introduction Proton beam therapy is an established primary treatment for patients with non-metastasized uveal melanoma. Adjuvant local interventions, like intravitreal injections or surgery, were shown to improve long-term eye preservation; however, their impact on the patient’s quality of life (QOL) remains unknown. Methods In a post-radiotherapeutic follow-up, we prospectively collected data on QOL
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Improved prognostic precision in uveal melanoma through a combined score of clinical stage and molecular prognostication Ocul. Oncol. Pathol. Pub Date : 2021-11-01 Andrew W. Stacey, Vaidehi S. Dedania, Miguel Materin, Hakan Demirci
Introduction: Prognosis of uveal melanoma (UM) is assessed using clinical staging or molecular testing. Two modalities often used for prognostication are the American Joint Committee on Cancer (AJCC) staging and a tumor gene expression profile (GEP), the outcomes of which are often discordant. This paper discusses a Total Risk Score created to combine the discordant information from both sources. Methods:
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Clinicopathological Features of 19 Eyelid Pilomatrixomas Ocul. Oncol. Pathol. Pub Date : 2021-10-25 Sepideh Siadati, Ashley A. Campbell, Timothy McCulley, Charles G. Eberhart
Introduction: Pilomatrixoma is a relatively rare, benign tumor arising from the hair root matrix. It is found frequently on the head and neck, with most involving the eyebrow in the periocular region. In contrast, eyelid pilomatrixoma is less common, and often clinically misdiagnosed. Here, we present clinical and histological data from 19 pilomatrixomas arising in the eyelid. Methods: The study represents
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Two cases of angiosarcoma with persistent unilateral eyelid swelling Ocul. Oncol. Pathol. Pub Date : 2021-10-21 Shinzo Sakisaka, Mika Tanabe, Shuhei Imayama, Nahoko Zeze, Kanako Yamana, Hiroshi Yoshikawa, Koh-Hei Sonoda
Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present two such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy
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Lacrimal Sac Tumors: A case series Ocul. Oncol. Pathol. Pub Date : 2021-10-18 Syeed Mehbub Ul Kadir, Riffat Rashid, Sadia Sultana, Murtuza Nuruddin, Mst. Sayedatun Nessa, Mukti Rani Mitra, Golam Haider