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CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis J. Egypt. Natl. Canc. Inst. Pub Date : 2024-03-18 Yan Liu, Kexin Zhang, Xianxu Yang
CircRNAs and miRNAs are involved in the progression of tumor. CircMCTP2 is considered as a novel tumor promoter. However, the exact functions of circMCTP2 in bladder cancer are still unclear. This study was designed to explore the underlying mechanisms of circMCTP2-modulated tumor development in bladder cancer. The present study is an original research. The levels of circMCTP2 in a total of 39 bladder
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Molecular perspectives on systemic priming and concomitant immunity in colorectal carcinoma J. Egypt. Natl. Canc. Inst. Pub Date : 2024-03-11 Suman Kumar Ray, Sukhes Mukherjee
The progression of metastasis, a complex systemic disease, is facilitated by interactions between tumor cells and their isolated microenvironments. Over the past few decades, researchers have investigated the metastatic spread of cancer extensively, identifying multiple stages in the process, such as intravasation, extravasation, tumor latency, and the development of micrometastasis and macrometastasis
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Developing an efficient method for melanoma detection using CNN techniques J. Egypt. Natl. Canc. Inst. Pub Date : 2024-02-26 Devika Moturi, Ravi Kishan Surapaneni, Venkata Sai Geethika Avanigadda
More and more genetic and metabolic abnormalities are now known to cause cancer, which is typically deadly. Any bodily part may become infected by cancerous cells, which can be fatal. Skin cancer is one of the most prevalent types of cancer, and its prevalence is rising across the globe. Squamous and basal cell carcinomas, as well as melanoma, which is clinically aggressive and causes the majority
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Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia J. Egypt. Natl. Canc. Inst. Pub Date : 2024-02-12 Salah Aref, Omnyia Khaled, Nadia El Menshawy, Emad Azmy, Mohamed Aref, Osama Salama, Nada Khaled
This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients’ outcomes. SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls. Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003
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Platelet-to-albumin ratio and radiation-induced lymphopenia—prognostic biomarker for carcinoma esophagus J. Egypt. Natl. Canc. Inst. Pub Date : 2024-02-05 Adrija Ghosh, Abhilash Dagar, Ram Pukar Bharat, Jaswin Raj, Dyuti Shah, Jyoti Sharma, Akash Kumar, Pritee A. Patil, Aman Sharma, Dayanand Sharma, Supriya Mallick
Esophageal cancer has a poor survival outcome with 5-year OS at 16.7% despite treatment. Some inflammation-based prognostic indicators like the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously studied as potential biomarker for predicting outcome in esophageal cancer. Recently, platelet-to-albumin ratio (PAR) has been reported as a promising prognostic
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PD-L1 expression and its significance in advanced NSCLC: real-world experience from a tertiary care center J. Egypt. Natl. Canc. Inst. Pub Date : 2024-01-29 Sindhu Kilaru, Soumya Surath Panda, Lalatendu Moharana, Debahuti Mohapatra, Satya Sundar G. Mohapatra, Adyakinkar Panda, Spoorthy Kolluri, Suma Devaraj, Ghanashyam Biswas
Targeted therapies against programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) have revolutionized the management in recent years. There is paucity of data on the significance of PD-L1 expression in NSCLC from India. We aimed to study the prevalence of PD-L1 expression and its relation with different clinico-pathological parameters in advanced NSCLC from a tertiary care center in
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Pulmonary metastatectomy in pediatric cancer patients at National Cancer Institute, Egypt: prognostic factors and outcome J. Egypt. Natl. Canc. Inst. Pub Date : 2024-01-22 Asmaa Hamoda, Inas Elattar, Heba Mahmoud, Mohamed Abdelrahman, Emad Ebied
Metastatic tumors account for 80% of all lung tumors in children. Wilms tumour and osteosarcoma are the most tumors of childhood that produce lung metastases. The aim of the current study is to assess the prognostic factors of pulmonary metastatectomy in pediatric solid tumours as age, number, size, site,laterality, resectability of pulmonary nodules, and number of Thoracotomies. Calculate overall
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Effect of combined Kinesiotaping and resistive exercise on muscle strength and quality of life in breast cancer survivors: a randomized clinical trial J. Egypt. Natl. Canc. Inst. Pub Date : 2024-01-15 Alaa M. Ramadan, Abeer M. ElDeeb, Ahmed A. Ramadan, Dina M. Aleshmawy
Breast cancer (BC) and its treatment affect women's tissue architecture and physiology, which leads to impaired muscle strength and joint dysfunction, affecting quality of life (QOL). Most evidence has focused on exercises; however, due to the complexity and heterogeneity of patients’ rehabilitation needs, further research is required to investigate more adjunctive methods to help optimal rehabilitation
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Peripheral Neutrophil to Lymphocyte Ratio (NLR), a cogent clinical adjunct for Ki-67 in breast cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-25 Radhika Arora, Feroz Alam, Atia Zaka-ur-Rab, Veena Maheshwari, Kiran Alam, Mahboob Hasan
Clinical utility of Ki-67 immunohistochemistry (IHC) in breast cancer (BC) is mainly limited to decide for the use of chemotherapy and estimate prognosis in patients with either Ki-67 index < 5% or > 30%; however, lacunae still exists pertaining to its analytical validity. Neutrophilia is common in cancer with accompanying lymphocytopenia. Neutrophil to lymphocyte ratio (NLR) captures the intricate
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Metabolic syndrome and breast cancer risk J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-21 Amira M. Mohammed, Hosney B. Hamed, Maisa K. Noaman, Nelly Alieldin
Limited data are available on metabolic syndrome and its relation to breast cancer risk in Egypt. We aimed to study metabolic syndrome and its individual components as risk of breast cancer. This case–control study recruited 112 breast cancer cases and 112 age-matched controls from Assiut University. In addition to demographic, clinical, and anthropoemetric characteristics, blood samples were collected
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REC8 regulates neuroblastoma cell proliferation, migration, invasion, and angiogenesis via STAT3/VEGF signaling J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-18 Qiang Wang, Wei Fan, ZengHui Hao, Bingxue Liang, Meili Fan, Zijian Zhao, Zhaozhu Li
Neuroblastoma, one of the most prevalent childhood cancers, is often treated with surgery, radiation, and chemotherapy. However, prognosis and survival are still dismal for children with neuroblastoma at high risk. Consequently, it is vital to identify new and effective treatment targets. As a component of the meiotic cohesion complex, REC8 is involved in a wide range of malignancies. The current work
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Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-14 Munehiro Wakabayashi, Yoshinori Kikuchi, Kazuhisa Yamaguchi, Takahisa Matsuda
Trousseau syndrome is a paraneoplastic syndrome associated with a risk of poor prognosis. We reviewed the survival time and prognosis of patients with Trousseau syndrome. We identified 40 cases from 28 reports of Trousseau syndrome due to pancreatic cancer. We analyzed 20 cases based on reports providing sufficient information on the stage/location of pancreatic cancer and survival time after Trousseau
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Impact of family history of cancer on colorectal cancer screening: a propensity score-matched analysis from the Health Information National Trends Survey (HINTS) J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-11 Maxwell Akonde, Eric Mishio Bawa, Ottovon Bismark Dakurah, Rajat Das Gupta
Early detection of colon cancer leads to better survival outcomes. This can be achieved through colorectal cancer (CRC) screening. People with a family history of cancer (FHC) have increased risk of developing CRC. Increasing screening in this group will reduce CRC mortality. This study evaluated CRC screening in people with FHC. The study used data from the Health Information National Trends Survey
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Distribution of high- and low-risk human papillomavirus genotypes and their prophylactic vaccination coverage among West African women: systematic review J. Egypt. Natl. Canc. Inst. Pub Date : 2023-12-07 Rogomenoma Alice Ouedraogo, Ali Kande, Wendyam Marie Christelle Nadembega, Djeneba Ouermi, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Charlemagne Marie Ragnag-Newende Ouedraogo, Olga Mélanie Lompo, Jacques Simpore
The second most deadly gynecological cancer worldwide, cervical cancer is steadily on the rise in sub-Saharan Africa, while vaccination programs are struggling to get off the ground. This systematic review’s aim was to assess the prevalence and distribution of high- and low-risk HPV genotypes in West African women. Original studies were retrieved from PubMed/Medline, Embase, Scopus, Google Scholar
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Review of current literature on gestational trophoblastic neoplasia J. Egypt. Natl. Canc. Inst. Pub Date : 2023-11-27 Mehwish Shahzadi, Saqib Raza Khan, Muhammad Tariq, Sehrish Sarwar Baloch, Aisha Shahid, Munira Moosajee, Zarka Samon
Gestational Trophoblastic Neoplasia (GTN) is a disease of the reproductive age group with an incidence rate of <1% among all tumors involving the female reproductive tract. It occurs because of aberrant fertilization. Patients are diagnosed early because of aggravated symptoms during pregnancy. Moreover, patients also bleed from the tumor sites, which leads to early presentation. A cure rate of 100%
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Targeting average length of hospital stay as a control measure to decrease COVID-19 hospital-acquired infection in surgical cancer patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-11-20 Sarah S. Nasr, Ghada M. Sherif, Maha Abdel Wahab, Hatem Aboelkasem
The global spread of coronaviruses had a great impact on the economic and social situation of most countries. As the backbone of any society, the health sector made a significant contribution through applying emergency risk management plans in order to control the pandemic. Monitoring the average length of hospital stay (ALOS) was an effective way to release the capacity of the health system during
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Stem cell therapy for hepatocellular carcinoma and end-stage liver disease J. Egypt. Natl. Canc. Inst. Pub Date : 2023-11-06 Mona S. Abdellateif, Abdel-Rahman N. Zekri
Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a great challenge for clinicians due to the limited chance for liver transplantation, which is the only curative treatment for those patients. Stem cell-based therapy as a part of regenerative medicine represents a promising application
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Ameloblastic fibro-dentinoma: a rare mixed odontogenic tumor case report with review of literature J. Egypt. Natl. Canc. Inst. Pub Date : 2023-10-30 Nihal Mohamed Ahmed Darwish, Hatem Wael Abdel-Fattah Amer, Nesma Nabil Mohamed Mahrous
Ameloblastic fibro-dentinoma is considered a rare, benign, mixed odontogenic tumor that occurs mainly in the posterior mandible in the 1st–2nd decade of life. Although the clinical behavior of Ameloblastic fibro-dentinoma is similar to that of ameloblastic fibroma, there is a debate about whether Ameloblastic fibro-dentinoma is a developing hamartomatous odontoma or a separate neoplastic odontogenic
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Photobiological modulation of hepatoma cell lines and hepatitis B subviral particles secretion in response to 650 nm low level laser treatment J. Egypt. Natl. Canc. Inst. Pub Date : 2023-10-23 Ghada M. Al-Toukhy, Reda A. Suef, Sarah Hassan, Mohamed M. S. Farag, Tarek A. El-Tayeb, Mohamed T. M. Mansour
Chronic hepatitis B virus (HBV) infection is a serious global health concern, with an increased incidence and risk of developing cirrhosis and hepatocellular carcinoma (HCC). Patients chronically infected with HBV are likely to experience chronic oxidative stress, leading to mitochondrial dysfunction. Photobiomodulation is induced by the absorption of low-level laser therapy (LLLT) with a red or infrared
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Immunotherapeutic strategy in the management of gastric cancer: molecular profiles, current practice, and ongoing trials J. Egypt. Natl. Canc. Inst. Pub Date : 2023-10-02 Mengxiao Lu, Yingjie Wu, Yixin Zhang, Yu Yu, ShengJie Wang, Xiaobao Su
Gastric cancer (GC) is the one of the most commonly solid cancer worldwide. Although under the aggressive treatment, the poor clinical outcomes of patients with GCs have not been improved. Current studies emphasized that targeting therapies or immune response-based therapeutic strategy may be a potential approach to improve the clinical outcomes. Moreover, accumulative evidence has reported the increasing
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Micronuclei detection in oral cytologic smear: does it add diagnostic value? J. Egypt. Natl. Canc. Inst. Pub Date : 2023-09-25 Alaa Elnaggar, Gihane Madkour, Neveen Tahoun, Ayman Amin, Fat’heya M. Zahran
Screening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated with increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented in the early detection as toluidine blue staining, optical imaging, and oral cytology. This study aimed to assess and compare the presence of micronuclei (MN) in oral exfoliative cytology of healthy controls
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Mandibular small cell osteosarcoma: a case report and review of literature J. Egypt. Natl. Canc. Inst. Pub Date : 2023-09-18 Hatem Wael Amer, Hana’a Hezam Algadi, Shyma’a Ahmed Hamza
Small cell osteosarcoma is an extremely rare histopathological variant of conventional osteosarcoma. Due to nonspecific symptoms, most osteosarcomas of the jaws are misdiagnosed as periapical abscesses and mistreated by teeth extraction and drainage. We report, to our knowledge, the seventh case of small cell osteosarcoma in gnathic sites affecting the mandible of an old female with history of a large
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Outcome and prognostic factors of pediatric patients with Hodgkin lymphoma: a single-center experience J. Egypt. Natl. Canc. Inst. Pub Date : 2023-09-11 Nesreen Ali, Mohamed Mansour, Ehab Khalil, Emad Ebeid
Hodgkin lymphoma (HL) is a highly curable malignant tumor. Risk-adapted treatment for children with HL aims to maximize survival while minimizing toxicity. The purpose of this study is to evaluate the outcome and prognostic characteristics of Egyptian pediatric HL patients treated at the National Cancer Institute (NCI), Cairo University. All newly diagnosed cases of classic HL treated between January
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The relationship between coping self-efficacy and B cells in breast cancer patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-09-04 Azza El-Amir, Eman M. El-Baiomy, Noha A. Sabry, Loay Kassem, Margaret A. Chesney, Kenneth A. Wallston
Breast cancer is the most common tumor among women throughout the world. Diagnosis and treatment of breast cancer are associated with stress and depression. Self-efficacy is one of the most important personal characteristics, studied in cancer, and is correlated with depression and immunity. The aim of the study is as follows: 1. Examining the correlation between coping self-efficacy with depression
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Mechanisms of HIF-driven immunosuppression in tumour microenvironment J. Egypt. Natl. Canc. Inst. Pub Date : 2023-08-30 Shinjini Bandopadhyay, Somi Patranabis
Hypoxia arises due to insufficient oxygen delivery to rapidly proliferating tumour cells that outpace the available blood supply. It is a characteristic feature of most solid tumour microenvironments and plays a critical role in regulating anti-tumour immunity, enhancing tumoral heterogeneity, and promoting therapeutic resistance and poor clinical outcomes. Hypoxia-inducible factors (HIFs) are the
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Prognostic value of S100A4 and Glypican-3 in hepatocellular carcinoma in cirrhotic HCV patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-08-21 Mahmoud El-Bendary, Khaled Farid, Mohammad Arafa, Wagdi Elkashef, Talaat Abdullah, Ahmed El-Mesery
Both S100A4 and Glypican-3 have been known to be engaged in HCC development and progression. This study aimed to evaluate both S100A4 and GPC3 expression in HCC tissues as a prognostic markers. Tissues from 70 patients of HCC in cirrhotic HCV patients were evaluated by immunohistochemistry using antibodies against SA100A4 and GPC3 and compared with tumor-adjacent tissue (controls). All cases were followed
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Bioinformatic analysis of KIT juxtamembrane domain mutations in Syrian GIST patients: jigsaw puzzle completed J. Egypt. Natl. Canc. Inst. Pub Date : 2023-08-14 Nour Pharaon, Wafa Habbal, Fawza Monem
The huge number of detected somatic KIT mutations highlights the necessity of in silico analyses that are almost absent in the relevant medical literature. The aim of this study is to report the mutation spectrum analysis of exon 11 encoding the juxtamembrane (JM) domain of the KIT gene in a group of Syrian GIST patients. Forty-eight formalin-fixed paraffin-embedded GIST tissue samples, collected between
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Ligand-based drug design of quinazolin-4(3H)-ones as breast cancer inhibitors using QSAR modeling, molecular docking, and pharmacological profiling J. Egypt. Natl. Canc. Inst. Pub Date : 2023-08-07 Sagiru Hamza Abdullahi, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba, Abdullahi Bello Umar
Breast cancer is the most common tumor among females globally. Its prevalence is growing around the world, and it is alleged to be the leading cause of cancer death. Approved anti-breast cancer drugs display several side effects and resistance during the early treatment stage. Hence, there is a need for the development of more effective and safer drugs. This research was aimed at designing more potent
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Immunohistochemical expression of P53 protein in nephroblastoma: a predictor of unfavorable prognosis J. Egypt. Natl. Canc. Inst. Pub Date : 2023-07-31 Emmanuel D. Morgan, James J. Yahaya, Advera I. Ngaiza, Emmanuel Othieno, Okwi A. Livex
Immunohistochemical expression of P53 protein is so closely related to status of mutation of P53 gene which is tightly linked with pathogenesis of nephroblastoma or Wilms tumor. This study aims to determine the immunohistochemical expression of P53 protein and its predictors in formalin-fixed paraffin-embedded tissue blocks of patients with nephroblastoma. A series of 83 histologically diagnosed cases
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Gene co-expression network construction and analysis for identification of genetic biomarkers associated with glioblastoma multiforme using topological findings J. Egypt. Natl. Canc. Inst. Pub Date : 2023-07-24 Seema Sandeep Redekar, Satishkumar L. Varma, Atanu Bhattacharjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. GBM patients usually have a poor prognosis. Identification of genes associated with the progression of the disease is essential to explain the mechanisms or improve the prognosis of GBM by catering to targeted therapy. It is crucial to develop a methodology for constructing a biological network and analyze
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Fluorodeoxyglucose positron emission tomography (18F-FDG PET)-computed tomography (CT) in the initial staging of bladder cancer: a single institution experience J. Egypt. Natl. Canc. Inst. Pub Date : 2023-07-17 Mohammed Shahait, Ramiz Abu-Hijlih, Ala’a Farkouh, Shahed Obeidat, Samer Salah, Ahmed Saad Abdlkadir, Akram Al-Ibraheem
The purpose of this study was to assess the usefulness of fluorodeoxyglucose positron emission tomography (18F-FDG PET)-computed tomography (CT) scan for staging urinary bladder cancer. The study also sought to determine the effect of 18F-FDG PET/CT on management decisions and its implications for patient care. A total of 133 patients with bladder cancer who had both conventional imaging and 18F-FDG
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Observer agreement in single computerized tomography use for diagnosing paediatric head and neck malignancies at Uganda Cancer Institute J. Egypt. Natl. Canc. Inst. Pub Date : 2023-07-10 Alex Mwesigwa Mugisha, Zeridah Muyinda, Joyce Balagadde Kambugu, Denise Apolot, Elizabeth Atugonza, Anneth Teu, Aloysius Gonzaga Mubuuke
In the Ugandan setting, investigation for PHNM with CT uses a protocol with both unenhanced and contrast enhanced procedures hence doubling the ionizing radiation exposure. The purpose of this study was to determine the feasibility of single CT procedures in diagnosing PHNM. This was a cross-sectional study using CT images from patients, aged fifteen years and below, investigated for head and neck
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Using the Precision Lasso for gene selection in diffuse large B cell lymphoma cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-06-26 Rashed Pourhamidi, Azam Moslemi
Gene selection from gene expression profiles is the appropriate tool for diagnosing and predicting cancers. The aim of this study is to perform a Precision Lasso regression model on gene expression of diffuse large B cell lymphoma patients and to find marker genes related to DLBCL. In the present case–control study, the dataset included 180 gene expressions from 14 healthy individuals and 17 DLBCL
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miR-155 and miR-92 levels in ALL, post-transplant aGVHD, and CMV: possible new treatment options J. Egypt. Natl. Canc. Inst. Pub Date : 2023-06-19 Mahdiyar Iravani Saadi, Mohsen Nikandish, Zahra Ghahramani, Fatemeh Mardani Valandani, Maryam Ahmadyan, Fakhroddin Hosseini, Zahra Rahimian, Heeva Jalali, Fataneh Tavasolian, Ehsan Nabi Abdolyousefi, Nadiya Kheradmand, Mani Ramzi
Acute lymphoblastic leukemia (ALL) is a malignancy that leads to altered blast cell proliferation, survival, and maturation and eventually to the lethal accumulation of leukemic cells. Recently, dysregulated expression of various micro-RNAs (miRNAs) has been reported in hematologic malignancies, especially ALL. Cytomegalovirus infection can induce ALL in otherwise healthy individuals, so a more detailed
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Clinical features, laboratory characteristics, and outcome of ETP and TCRA/D aberrations in pediatric patients with T-acute lymphoblastic leukemia J. Egypt. Natl. Canc. Inst. Pub Date : 2023-06-12 Mona S. El Ashry, Enas Radwan, Mona S. Abdellateif, Omar Arafah, Naglaa M. Hassan
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few accepted prognostic factors that limit the efficiency of therapy. The aim of the current study was to assess the clinical and laboratory features of T-cell receptor (TCR) aberrations and early T-cell precursor (ETP) subtype as well as their outcome to therapy. Sixty-three newly diagnosed pediatric T-ALL patients were assessed
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The conundrum of metaplastic breast cancer: a single Egyptian institution retrospective 10-year experience (2011–2020) J. Egypt. Natl. Canc. Inst. Pub Date : 2023-06-05 Yahia Ismail, Amr Kamal, Rasha Allam, Al-Shimaa Zakaria
Metaplastic breast cancer (MetBC) still represents a conundrum owing to its peculiar histogenesis and molecular drivers that render it extremely resistant to standard chemotherapy with ultimate dismal survival. Describe the Egyptian National Cancer Institute’s (NCI-E) experience with MetBC regarding its clinicopathologic features, treatment, and survival outcomes. Between 2011 and 2020, all MetBC patients
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Identification of crucial genes involved in thyroid cancer development J. Egypt. Natl. Canc. Inst. Pub Date : 2023-05-22 Iyshwarya Bhaskar Kalarani, Ganesan Sivamani, Ramakrishnan Veerabathiran
A malignancy of the endocrine system, one of the most common types, is thyroid cancer. It is proven that children who receive radiation treatment for leukemia or lymphoma are at a heightened risk of thyroid cancer due to low-dose radiation exposure throughout childhood. Several factors can increase the risk of thyroid cancer (ThyCa), such as chromosomal and genetic mutations, iodine intake, TSH levels
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Mutational signatures for breast cancer diagnosis using artificial intelligence J. Egypt. Natl. Canc. Inst. Pub Date : 2023-05-15 Patrick Odhiambo, Harrison Okello, Annette Wakaanya, Clabe Wekesa, Patrick Okoth
Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures are suspected to lead to progression of various breast cancer scenarios. There is paucity of data on the role of AI tools in delineating breast cancer mutational signatures. This study sought to
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Programmed death ligand 1 expression in diffuse large B cell lymphoma: correlation with clinicopathological prognostic factors J. Egypt. Natl. Canc. Inst. Pub Date : 2023-05-08 Eman Mohamad Ibrahim, Sherine Refat, Shaimaa El-Ashwah, Maryan Waheeb Fahmi, Afaf Taha Ibrahiem
The prognostic value of the level of programmed death ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) is still debatable. This study examined the effect of the level of PD-L1 expression on the clinicopathological characteristics and prognosis of diffuse large B cell lymphoma (DLBCL). A retrospective study was conducted on formalin-fixed paraffin-embedded tissue blocks of one hundred de novo
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Evaluation of short-term outcomes of neoadjuvant chemotherapy followed by radical cystectomy in muscle-invasive bladder cancer: a single Egyptian institution experience J. Egypt. Natl. Canc. Inst. Pub Date : 2023-05-05 Ibrahim Abdelrahman, Hatem Aboulkassem, Abdallah Elazab, Ahmed Younis Abdallah, Yahia Ismail, Mohammad Taher
Neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) became the standard of care for muscle-invasive bladder cancer (MIBC) in the last few years. We aimed to evaluate the radiological, pathological responses to NAC, and the 30-day surgical outcomes after RC in MIBC. A retrospective cohort study involving adult patients with localized urothelial MIBC who received NAC followed by RC at the National
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Noninvasive identification of molecular biomarkers of hepatocellular carcinoma in HCV-Egyptian patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-05-01 Ahmed Daif, Mahmood A. Al-Azzawi, Moustafa A. Sakr, Hisham A. Ismail, Mahmoud Gadallah
This study was performed to investigate the expression of different biomarkers in patients with hepatocellular carcinoma and its connection with detective biomarkers. To achieve this objective, seventy subjects were examined in this study, sub-grouped to forty HCC patients and thirty HCV-affected patients with matched thirty healthy individuals. The study involved several groups of participants who
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Organ preservation strategy: new therapeutic alternative in rectal cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-04-24 F. Safini, B. Amaoui, S. Semghouli, N. Aqodad
The therapeutic modalities for nonmetastatic rectal cancer are presently undergoing major changes. The standard treatment is multidisciplinary, combining radiotherapy, chemotherapy, and surgery. The aim of this minireview is to provide an update on the place of organ preservation in the treatment of nonmetastatic rectal cancer in 2022. The multimodal strategy based on initial radiochemotherapy followed
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Evaluation of health-related quality of life and its domains in pediatric patients with cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-04-17 Mai Sabry Saleh, Asmaa Mahmoud Mohammed, Dina Bassiouni, Hend Helmy Mostafa, Zeinab Mohammed Monir
Health-related quality of life has emerged as a significant component in pediatric oncology research during the last several decades. Measures of health-related quality of life provide a thorough assessment of the child’s response to medical therapy, disease course, and adjustment outcomes in the context of pediatric oncology. The aim of the present study was to assess the cancer-specific health-related
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Network and functional analyses of differentially expressed genes in gastric cancer provide new biomarkers associated with disease pathogenesis J. Egypt. Natl. Canc. Inst. Pub Date : 2023-04-10 Mousa Fadaei, Maryam Kohansal, Omidreza Akbarpour, Mahsa Sami, Ali Ghanbariasad
Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease. This study aimed to evaluate the association between differentially expressed genes (DEGs), which may function as potential biomarkers, and the diagnosis and treatment
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Molecular patterns of egyptian patients with non-squamous non-small-cell lung cancers: a clinicopathological study J. Egypt. Natl. Canc. Inst. Pub Date : 2023-04-03 Mohamed Said Ismail, Loay Kassem, Ahmed Al-Husseiny Ali, Fatma Elzahraa Ahmed, Mohamed Shalaby, Sally Magdy
Driver molecular aberrations, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement, play an important role in the oncogenesis and progression of non-squamous non-small-cell lung cancers (NSCLC). Therefore, this study aimed to detect the incidence of driver mutations among non-squamous NSCLC. This was a retrospective-prospective cohort study
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In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells J. Egypt. Natl. Canc. Inst. Pub Date : 2023-03-27 Nur Dina Amalina, Irfani Aura Salsabila, Ummi Maryam Zulfin, Riris Istighfari Jenie, Edy Meiyanto
We previously reported that in highly metastatic breast cancer cells, doxorubicin (DOX) at non-toxic concentrations promoted cell migration and invasion. Hesperidin (30, 5, 9-dihydroxy-40-methoxy-7-orutinosyl flavanone) is a flavonoid glycoside isolated from citrus/lemon plant that possesses a cytotoxic effect in several cancer cells. In this study, we investigate whether DOX efficacy is enhanced by
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Impact of changing PI-RADS cutoff on prostate cancer detection by MRI cognitive fusion biopsy in biopsy-naïve patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-03-06 Hesham Abdel-Azim El-Helaly, Asem Abdel-Aziz Mahmoud, Ahmed Mohamed Magdy, Abdelwahab Hasehem, Hamdy Mohamed Ibrahim, Khaled Moheyelden Mohamed, Mohamed Hamdy Ismail
Multi-parametric magnetic resonance imaging may improve the detection of prostate cancer. The aim of this work is to compare between PI-RADS 3–5 and PI-RADS 4–5 as a threshold for targeted prostatic biopsy. This is a prospective clinical study that included 40 biopsy-naïve patients referred for prostate biopsy. Patients underwent prebiopsy multi-parametric (mp-MRI), followed by 12-core transrectal
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Studying ferroptosis and iron metabolism pre- and post-radiotherapy treatment in breast cancer patients J. Egypt. Natl. Canc. Inst. Pub Date : 2023-02-27 Sanaa A. El-Benhawy, Ibrahim G. Abdelrhman, Nadia A. Sadek, Enayat I. Fahmy, Ahmed A. AboGabal, Hossam Elmasry, Sally A. M. Saleh, Ola A. Sakr, Mona Nagy Elwany, Maha Abubakr Feissal Rabie
Radiotherapy (RT) is an important part of the treatment of many tumors. Radiotherapy causes oxidative damage in all cellular compartments, including lipid membrane, on a random basis. Toxic lipid peroxidation accumulation has only lately been linked to a regulated type of cell death known as ferroptosis. Iron is required for ferroptosis sensitization in cells. This work aimed to study ferroptosis and
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The incidence and trends of laryngeal malignancies in Sri Lanka from 2001 to 2019: a Joinpoint analysis of the national cancer database J. Egypt. Natl. Canc. Inst. Pub Date : 2023-02-21 Umesh Jayarajah, Ravindri Jayasinghe, Ashan Fernando, Sanjeewa Seneviratne
Laryngeal cancer is the ninth commonest cancer among Asian males. Global and regional epidemiological analyses have shown varying patterns in the incidence and risk factors for laryngeal cancer. Therefore, we aimed to analyse the trends in the incidence and histological patterns of laryngeal cancers for the first time in Sri Lanka. We used the population-based Sri Lanka cancer registry data and pooled
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Parotid gland masses: outcomes in the pediatric age group J. Egypt. Natl. Canc. Inst. Pub Date : 2023-02-06 Alaa Younes, Mohammad Fouad Taher, Iman Sidhom, Wael Zekri, Iman Zaky, Habiba Elfendy, Azza Niazy Taher, Suzan Adlan Khedr, Rana Gamal, Gehad Ahmed
Childhood parotid neoplasms appear to have different characteristics from adults. This point, in addition to the rarity of these tumors, reflects the challenges faced in diagnosing and treating parotid neoplasms in children. This retrospective study included all children who presented to the Children’s Cancer Hospital Egypt (CCHE, 57357) with parotid masses from January 2008 to December 2020. Twenty-one
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Impact of cetuximab plus cisplatin alone and cetuximab plus cisplatin and paclitaxel regimen on humanistic outcome in head and neck cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-01-19 Avinash Khadela, Bhavin Vyas, Mustakim Mansuri, Dipen Sureja, Kunjan Bodiwala
The prevalence of head and neck cancer (HNC) is increasing rapidly, and the prognosis is poor in the advance stage. For the patient suffering from advance stage HNC, the improvement in quality of life and decrease mortality remain as the mainstay of treatment. The aim was to assess the change in quality-adjusted life-years (QALYs) in recurrent or metastatic HNC patients receiving cetuximab plus cisplatin
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Combination of chemotherapeutic agents and biological response modifiers (immunotherapy) in triple-negative/Her2( +) breast cancer, multiple myeloma, and non-small-cell lung cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2023-01-02 Morse, William, Nawaz, Haroon, Choudhry, Ayesha A.
Biological response modifiers (immunotherapy) in combination to chemotherapy are superior to that of chemotherapy in treatment of breast cancer (triple-negative/HER-2 ( +)), multiple myeloma, and non-small-cell lung cancer. This review article consists of a total of eighteen independent randomized controlled clinical trials ranging from phases one to three. Patients were randomly selected for immunomodulatory
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Primary therapy of early breast cancer: Egyptian view of 2021 St. Gallen consensus J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-26 Khaled, Hussein, Nada, Yousry Wasef, Ramadan, Kareem Mohamed, Fekry, Shawkat, Seleam, Mohamed Samy, Gaafar, Rabab, Lotayef, Mohamed
The theme of the St. Gallen International Breast Cancer Conference 2021 held virtually for the first time, due to the COVID-19 pandemic, was on tailoring therapies for patients with early breast cancer. A monkey survey that included an Egyptian Panel voted on most of the questions of the original St. Gallen consensus, and some added new questions most relevant to oncology practice in the country, to
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Identification of significant genes associated with prognosis of gastric cancer by bioinformatics analysis J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-26 Wang, Shuanhu, Tao, Song, Liu, Yakui, Shi, Yi, Liu, Mulin
Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric cancer are not clear. Here, we used integrated bioinformatics to identify possible key genes and reveal the pathogenesis and prognosis of gastric cancer. The gene expression profiles of GSE118916, GSE79973, and GSE29272 were available from the Gene Expression
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Six potential biomarkers for bladder cancer: key proteins in cell-cycle division and apoptosis pathways J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-19 Inal Gültekin, Güldal, Timirci Kahraman, Özlem, Işbilen, Murat, Durmuş, Saliha, Çakir, Tunahan, Yaylim, İlhan, Isbir, Turgay
The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the molecular pathogenesis of BC and its subtypes remains debatable. The bioinformatic analysis evaluates high numbers of proteins in a single study, increasing the opportunity to identify possible biomarkers for disorders. The aim of this study is to
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Predictors of peritoneal metastasis of gastric origin J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-19 ElKordy, Mohamed Atef, Soliman, Rady Mansour, ElTohamy, Mahitab Ibrahim, Mohamed, Dalia Negm Eldin, Mustafa, Ahmed Morsi
Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant number of cases. The role of surgery in the management of metastatic gastric cancer is very limited, reducing the value of conducting laparotomies. In addition, conducting laparoscopies for the
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Genomic landscape of mature B-cell non-Hodgkin lymphomas — an appraisal from lymphomagenesis to drug resistance J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-12 Panda, Devasis, Das, Nupur, Thakral, Deepshi, Gupta, Ritu
Mature B-cell non-Hodgkin lymphomas are one of the most common hematological malignancies with a divergent clinical presentation, phenotype, and course of disease regulated by underlying genetic mechanism. Genetic and molecular alterations are not only critical for lymphomagenesis but also largely responsible for differing therapeutic response in these neoplasms. In recent years, advanced molecular
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Comparison of mammosphere formation from stem-like cells of normal breast, malignant primary breast tumors, and MCF-7 cell line J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-12 Ambrose, Jenifer Mallavarpu, Veeraraghavan, Vishnu Priya, Vennila, Rosy, Rupert, Secunda, Sathyanesan, Jeswanth, Meenakshisundaram, Rajasundari, Selvaraj, Sakthivel, Malayaperumal, Sarubala, Kullappan, Malathi, Dorairaj, Sudarsanam, Gujarathi, Jayesh R., Gandhamaneni, Sri Harshini, Surapaneni, Krishna Mohan
Mammosphere formation assay has become a versatile tool to quantify the activity of putative breast cancer stem cells in non-adherent in vitro cultures. However, optimizing the suspension culture system is crucial to establish mammosphere cultures from primary breast tumors. This study aimed at determining the self-renewal and sphere-forming potential of breast cancer stem-like cells derived from human
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MUTYH and KLF6 gene expression fluctuations in tumor tissue and tumor margins tissues of colorectal cancer J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-05 Naebi, Hoora, Bandegi, Ahmadreza, Talebinasab, Fereshteh, Samidoust, Pirouz, Norollahi, Seyedeh Elham, Vahidi, Sogand, Samadani, Ali Akbar
Colorectal cancer (CRC) is one of the most important cancers in the world, and its prevalence varies depending on the geographical area. Genetically, tumor regeneration in CRC as a multi-step process involves activating mutations in protocogenes and losing the function of tumor suppressor genes as well as DNA repair and recovery genes. Occur in this way, our goal was to investigate the expression of
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Predicting factors for breast cancer screening in Middle Eastern women based on health belief model: a systematic review J. Egypt. Natl. Canc. Inst. Pub Date : 2022-12-05 Bahri, Narjes, Mardani, Fariba, Sharifi, Neda, Dashti, Sareh
Breast cancer screening can reduce mortality and improve the quality of life in affected women. The present study aimed to determine the predictive factors of breast cancer screening in Iranian women based on the health belief model (HBM). This review was conducted by searching electronic databases of Google Scholar; electronic databases, including Scopus, PubMed/MEDLINE, Cochrane Library, Web of Science