样式: 排序: IF: - GO 导出 标记为已读
-
Correction Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-03-10
Published in Pediatric Hematology and Oncology (Ahead of Print, 2024)
-
Vomiting in children and adolescents receiving intravenous pegaspargase: a retrospective study Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-03-07 Jamie M. Brown, Sherry Mathew, Maria Luisa Sulis, L. Lee Dupuis, Jennifer Thackray
Due to an evidence gap, the emetogenicity of intravenous (IV) pegaspargase was unable to be included in the clinical practice guideline classifying chemotherapy emetogenicity in pediatric patients....
-
Co-transplantation of umbilical cord mesenchymal stem cells and peripheral blood stem cells in children and adolescents with refractory or relapsed severe aplastic anemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-03-04 Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic...
-
Factors Related to the Quality of Life in Children with Transfusion-Dependent Thalassemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-29 Dea Aprilianti Permana, Susi Susanah, Riyadi Adrizain, Sri Endah Rahayuningsih, Meita Dhamayanti, Lulu Eva Rakhmilla
Objective: Increased survival rate of patients with Transfusion-dependent Thalassemia (TDT) should be in line with their good quality of life (QoL). The study aimed to analyze the relationship betw...
-
Management of a major varicella zoster exposure in a pediatric oncology population Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-20 Carol Rossetto, Kent Sepkowitz, Jill Ackerman, Rachel Corke, Nina J. Pickett, Wini Cudjoe, Janet Eagan, Mini Kamboj, Richard J. O’Reilly, Farid Boulad
Management of the exposure of pediatric oncology patients to varicella zoster virus (VZV) is controversial. We report the exposure of 56 patients to a single child with chicken pox at a pediatric c...
-
Endoscopic findings and predictors of gastrointestinal lesions in children with iron deficiency anemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-10 Hyun Jin Kim, Yeon Jung Lim
Iron deficiency anemia (IDA) can be caused by occult gastrointestinal (GI) blood loss; however, the endoscopic findings in children with anemia are unclear. The study aimed to determine the frequen...
-
Application of microRNAs in the diagnosis and monitoring of pediatric germ cell tumors: Kazakh experience Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-10 Symbat Saliyeva, Riza Boranbayeva, Minira Bulegenova, Vyacheslav Beloussov
GCT is characterized by specific biochemical markers expression, such as human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP), which are the main tools in the diagnosis and monitoring of ...
-
Access to Methotrexate Monitoring in Latin America: A Multicountry Survey of Supportive Care Capacity Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-10 Gabriela Villanueva, Jennifer Lowe, Nicolás Tentoni, Ankit Taluja, Milena Villarroel, Carlos E. Narváez, Sandra Alarcón León, Diana L. Valencia Libreros, Natalia Gonzalez Suárez, Torben S. Mikkelsen, Scott C. Howard
High-dose methotrexate (HDMTX) is used to treat a broad spectrum of cancers. Methotrexate (MTX) monitoring and adequate supportive care are critical for safe drug administration; however, MTX level...
-
Survival outcomes of myeloid leukemia associated with Down syndrome and de novo acute myeloid leukemia in children: Experience from a single tertiary center in Thailand Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-10 Natsaruth Songthawee, Pornpun Sripornsawan, Shevachut Chavananon, Sirinthip Kittivisuit, Edward B. McNeil, Thirachit Chotsampancharoen
Few studies have reported the survival outcomes of myeloid leukemia associated with Down syndrome (DS) in resource-limited countries. This study aimed to compare characteristics and survival outcom...
-
Outcome of allogeneic stem cell transplant for Fanconi anemia in India Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-10 Satya Prakash Yadav, Revathi Raj, Ramya Uppuluri, Dharma Choudhary, Divya Doval, Vikas Dua, Sunil Bhat, Gaurav Kharya, Rajesh Patil, Shweta Bansal, Deendayalan M, Intezar Mehdi, Vikram Mathews, Aby Abraham, Biju George
Published in Pediatric Hematology and Oncology (Vol. 41, No. 2, 2024)
-
The significance of surveillance imaging in children with Ewing sarcoma and osteosarcoma Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-02-12 Scott Greve Brekke, Arne Lucke, Henrik Hasle, Thomas Baad-Hansen
Primary bone tumors in children and adolescents, while rare, pose significant challenges in diagnosis and management. Children treated for Ewing sarcoma and osteosarcoma are offered a 5-year follow...
-
The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-01-25 Angela Zanfardino, Patrizia Bruzzi, Michela Trada, Novella Rapini, Emanuela Laudani, Gianluca Tornese, Federica Ortolani, Gianluca Piccolo, Lorena Matonti, Maria Alessandra Saltarelli, Tiziana Timpanaro, Giuseppe D’Annunzio, Barbara Predieri, Francesca Rossi, Rossella Mura, Veronica Barat, Arcangelo Prete, Riccardo Schiaffini, Stefano Zucchini, Diabetes Study Group of the Italian Society for Pediatric
Glycemic abnormalities are a frequent finding in pediatric oncological patients, both during treatment and after its discontinuation. Moreover, impaired glucose tolerance (IGT), impaired fasting gl...
-
Cost and effectiveness comparison of sirolimus versus standard treatment in Kasabach-Merritt phenomenon: a real-world evidence study in Thailand Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-01-18 Chanikarn Tongruang, Siriwan Wananukul, Susheera Chatproedprai, Nattee Narkbunnam, Rattanavalai Nitiyarom, Nongnuch Sirachainan, Rungrote Natesirinilkul, Phumin Chaweephisal, Darintr Sosothikul
The conventional treatment of Kasabach-Merritt Phenomenon (KMP) consists of corticosteroids with vincristine/vinblastine or others. The aim of the study is to compare the first-year direct costs an...
-
Challenges in Management of Pediatric Chronic Myeloid Leukemia (pCML) in the Low-Middle Income Countries (LMICs): Insights from an International CML Foundation (iCMLf) Multi-National Survey Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-01-16 Nirmalya Roy Moulik, Arlene Harriss-Buchan, Giuseppe Saglio, Meinolf Suttorp
Despite being a rare disease, high-income countries (HICs) have formulated guidelines for management of pediatric CML (pCML). We conducted a survey amongst 24 physicians from 22 Low-Middle Income C...
-
Treatment outcomes in patients with Ewing sarcoma of the spine in a resource-challenged setting: 17-year experience from a single center in India Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2024-01-08 Archana Sasi, Sindhura Chitikela, Shuvadeep Ganguly, Bivas Biswas, Deepam Pushpam, Akash Kumar, Shah Alam Khan, Venkatesan Sampath Kumar, Shashank Sharad Kale, Ahitagni Biswas, Adarsh Barwad, Asit Ranjan Mridha, Sanjay Thulkar, Sameer Bakhshi
Ewing sarcoma (ES) of the spine is a rare childhood cancer with sparse literature on treatment outcomes. We aimed to describe survival outcomes and prognostic factors in patients with spinal ES tre...
-
Hematopoietic stem cell transplantation for B-thalassemia major with alemtuzumab Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-12-22 Luisanna M. Sánchez, Anil George, Brian D. Friend, Saleh Bhar, Ghadir Sasa, Erin E. Doherty, John Craddock, David Steffin, Baheyeldin Salem, Khaled Yassine, Bilal Omer, Caridad Martinez, Kathryn Leung, Robert A. Krance, Tami D. John
While matched related donor (MRD) allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for transfusion-dependent beta-thalassemia (TDT), the use of alternative sources has...
-
Can N-acetylcysteine reduce red blood cell transfusion burden in patients with transfusion-dependent β-thalassemia? Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-12-13 Gholamreza Bahoush, Mahdi Rahab, Parnian Ahmadvand
Patients with beta-thalassemia major require lifelong and frequent red blood cell transfusions for survival, impacting their quality of life and life expectancy. This treatment approach poses risks...
-
A case of autoimmune lymphoproliferative syndrome with a novel de novo FAS variant Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-12-04 Firat Ozcelik, Kubra Aslan, Veysel Gok, Mucahit Bilgehan Ari, Alper Ozcan, Ahmet Eken, Ekrem Ünal, Yusuf Ozkul, Munis Dundar
Published in Pediatric Hematology and Oncology (Ahead of Print, 2023)
-
The Onset of Puberty Presents Unique Management Issues in Penile Chronic Graft-versus-Host Disease Requiring Circumcision in Male Pediatric Patients Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-11-07 Chia Huan Ng, Juliana P. Roden, Jefferson Terry, Kirk R. Schultz
Chronic GvHD of the penile tract in male pediatric patients has not been described well in the literature and is often under-diagnosed. We report three cases of penile chronic GvHD in adolescent ma...
-
Intractable abdominal pain as the sole symptom of Varicella Zoster reactivation after allogeneic stem cell transplantation: brief case report and review of the literature Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-10-29 Yogi Chopra, Carly Hong, Tal Schechter, Muhammad Ali, Kuang-Yueh Chiang, Donna Wall, Joerg Krueger
After primary infection, Varicella Zoster (VZV) persists in sensory dorsal root ganglia and may be reactivated in periods of diminished T-cell immunity. Varicella Zoster reactivation post allogenic...
-
Sustained improvement in IPEX-like syndrome course following failed umbilical cord blood transplantation Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-10-29 Ishaq Alkooheji, Elizabeth Secord, Colleen Buggs-Saxton, Tony Lulgjuraj, Süreyya Savaşan
Published in Pediatric Hematology and Oncology (Ahead of Print, 2023)
-
Successful haploidentical bone marrow transplantation in Griscelli syndrome type 2 with non-busulfan-based regimen and post-transplantation cyclophosphamide: a case report and review of the literature Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-10-31 Saori Yamada, Yuta Maruyama, Shoji Saito, Kazutoshi Komori, Hirokazu Morokawa, Eri Okura, Koichi Hirabayashi, Yu Furui, Takashi Kurata, Makoto Nishioka, Tetsuhiro Fukuyama, Kazuo Sakashita, Yozo Nakazawa
Published in Pediatric Hematology and Oncology (Ahead of Print, 2023)
-
Intra-arterial methylprednisolone for pediatric gastrointestinal post-transplant lymphoproliferative disorder Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-10-20 Hoyoung Jung, Ravjot Dhatt, S. Rod Rassekh, Manraj K. S. Heran
Published in Pediatric Hematology and Oncology (Ahead of Print, 2023)
-
Psychosocial and mental profile of children with sickle cell disease and their caregivers Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-09-29 Fatma S. E Ebeid, Galila Mohamed Mokhtar, Eman Ahmed Zaky, Reham Ibrahim Abdelmageed, Nermeen Mohamed Elkamel, Heba G. A Ali
Sickle cell disease (SCD), a chronic debilitating disorder that may negatively affect health-related quality-of-life (HRQoL). In this observational, case–control study, we aim to assess the prevale...
-
Noncompliance of pediatric cancer patients with chemotherapy: A single-center experience in a lower-middle income country Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-09-23 A. Farrag, K. Mohammed, M.H. Ghazaly, F. Berthold
Noncompliance with therapy is a big obstacle to successful therapy. We aimed to evaluate the prevalence and risk factors affecting the compliance of pediatric cancer patients with therapy in a tert...
-
Safety of Procalcitonin Guided Early Discontinuation of Antibiotic Therapy among Children Receiving Cancer Chemotherapy and Having Low-Risk Febrile Neutropenia: A Randomized Feasibility Trial (ProFenC Study) Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-09-01 Prasanth Srinivasan, Jagdish Prasad Meena, Aditya Kumar Gupta, Ashutosh Halder, Arti Kapil, Ravindra Mohan Pandey, Rachna Seth
In low-risk febrile neutropenia (LR-FN), the safety of early discontinuation of empiric antibiotics without marrow recovery is not well established. This study aimed to evaluate the safety of proca...
-
The role of pediatric oncologist in prenatal diagnosis: A 10-year retrospective study at Assistance Publique Hôpitaux de Marseille (AP-HM) Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-08-21 Victoria Min, Stephanie Coze, Claude D’Ercole, Nicoleta Panait, Sabine Sigaudy, Audrey Aschero, Helene Zattara, Florence Bretelle, Gabriel Revon-Riviere, Carole Coze
Solid tumors or predisposition syndromes are increasingly suspected before birth. However optimal management and outcomes remain unclear. We have performed a ten-year retrospective study of oncolog...
-
ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-08-14 Nermeen R. Al-Zayan, Mohammed J. Ashour, Hadeer N. Abuwarda, Fadel A. Sharif
Acute lymphoblastic leukemia (ALL) is the most frequent type of pediatric cancer. Germline single nucleotide polymorphisms (SNPs), including ARID5B (rs10821936 T/C), IKZF1 (rs4132601 T/G), GATA3 (r...
-
Novel Strategy Involving High-Dose Chemotherapy with Stem Cell Rescue Followed by Intrathecal Topotecan Maintenance Therapy without Whole-Brain Irradiation for Atypical Teratoid/Rhabdoid Tumors Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-30 Ai Yamada, Mariko Kinoshita, Sachiyo Kamimura, Takashi Jinnouchi, Minako Azuma, Shinji Yamashita, Kiyotaka Yokogami, Hideo Takeshima, Hiroshi Moritake
Abstract Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive central nervous system tumor that typically affects children under three years old and has poor survival with a high risk for neurologic deficits. The primary purpose of this study was to successfully treat the disease and delay or avoid whole-brain radiotherapy for children with AT/RT. A retrospective analysis was performed for
-
Thalassemia patients in transfussion dependent period and after hematopoietic stem cell transplantation: how are the psychiatric status and life quality of these patients? Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-30 Merve Cikili-Uytun, Mehtap Eroglu, Mehmet Ertem, Dilber Talia İleri, Elif Ince, Birim Günay Kilic
Abstract Although hematopoietic stem cell transplantation (HSCT) has been widely used to treat patients with beta-thalassemia major, evidence showing whether this treatment improves mental health, self esteem and health-related quality of life (HRQoL) is limited. We aimed to describe psychiatric problems, HRQoL and self-esteem scores of patients who have thalassemia and compared with patients who underwent
-
Potential role of serum vitamin D as a risk factor in pediatric acute lymphoblastic leukemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-21 Pardis Nematollahi, Sina Arabi, Marjan Mansourian, Saeed Yousefian, Alireza Moafi, Sayed Nassereddin Mostafavi, Amirmansour Alavi Naeini, Afshin Ebrahimi, Karim Ebrahimpour, Mohammad Mehdi Amin, Aryan Kavosh, Shirin Mahmoudi kohi, Roya Kelishadi
Abstract Vitamin D deficiency/insufficiency (VDD, VDI) is common in children yet limited experience exists on the association of VDD and hematologic malignancies amongst this population. Therefore, this study aimed to compare serum vitamin D levels in children with acute lymphoblastic leukemia (ALL) and controls. Moreover, vitamin D levels is compared in subjects with and without relapse and evaluated
-
What happens to children with acute lymphoblastic leukemia in low- and middle-income countries after relapse? A single-center experience from India Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-21 Richa Sharon Angel Korrapolu, Deepthi Boddu, Rikki John, Nikita Antonisamy, Tulasi Geevar, Arun Kumar Arunachalam, Leenu Lizbeth Joseph, Hema Nalapullu Srinivasan, Leni Grace Mathew, Sidharth Totadri
Abstract Managing a child with acute lymphoblastic leukemia (ALL) after relapse is arduous in low- and middle-income countries. A file review of children aged ≤15 years diagnosed with relapsed ALL from 2010 to 2019 was performed. Classification of relapse followed the Berlin-Frankfurt-Münster (BFM) scheme. The majority of patients were treated with a modified ALL-REZ-BFM protocol. Of 764 children treated
-
Clinical profile and outcome of children with anaplastic large cell lymphoma treated with short-course chemotherapy – ten years experience from a tertiary care center in a LMIC Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-21 Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, C S Guruprasad, V R Prasanth, Rekha A. Nair, K M Jagathnath Krishna
Abstract Anaplastic large-cell lymphoma (ALCL) constitutes 10–15% of non-Hodgkin lymphoma in children. With short-course chemotherapy, outcome has improved up-to 90% in developed-countries. There is limited-data on outcome of pediatric ALCL treated with ALCL99 protocol from low-middle income countries. Children ≤14 years, diagnosed with ALCL between 1st January 2007 and 31st December 2016 were analyzed
-
Contribution of Fatigue to Cognitive Dysfunction in Childhood Acute Lymphoblastic Leukemia Survivors Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-20 Alice Mochon, Sarah Lippé, Maja Krajinovic, Caroline Laverdière, Stacey Marjerrison, Bruno Michon, Philippe Robaey, Émélie Rondeau, Daniel Sinnett, Serge Sultan
Abstract Late effects such as neurocognitive issues and fatigue have been reported in childhood acute lymphoblastic leukemia (cALL) survivors. Yet, their association is often poorly understood. In this study, we wished to (1) describe neurocognitive difficulties and fatigue in a well-characterized cohort of long-term cALL survivors and (2) explore the risk of having neurocognitive deficits as a function
-
The predictive utility of cytokines, procalcitonin and C-reactive protein among febrile pediatric hematology and oncology patients with severe sepsis or septic shock Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-15 Shu-Peng Lin, Xiao-Jun Xu, Chan Liao, Ning Zhao, Yuan-Yuan Chen, Hua Song, Wei-Qun Xu, Juan Liang, Di-Ying Shen, Jing-Ying Zhang, He-Ping Shen, Fen-Ying Zhao, Yong-Min Tang
Severe sepsis and septic shock are life-threatening for pediatric hematology and oncology patient receiving chemotherapy. Th1/Th2 cytokines, C-reactive protein (CRP), and procalcitonin (PCT) are al...
-
Substrate oxidation during exercise in childhood acute lymphoblastic leukemia survivors Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-07-13 Émilie Bertrand, Maxime Caru, Sophia Morel, Alice Bergeron Parenteau, Veronique Belanger, Caroline Laverdière, Maja Krajinovic, Daniel Sinnett, Emile Levy, Valérie Marcil, Daniel Curnier
Children with acute lymphoblastic leukemia (ALL) are at high risk of developing long-term cardiometabolic complications during their survivorship. Maximal fat oxidation (MFO) is a marker during exe...
-
Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-06-27 Ross Mangum, Jacquelyn Reuther, Koel Sen Baksi, Ilavarasi Gandhi, Ryan C. Zabriskie, Alva Recinos, Robin Raesz-Martinez, Frank Y. Lin, Samara L. Potter, Andrew C. Sher, Stephen F. Kralik, Carrie A. Mohila, Murali M. Chintagumpala, Donna Muzny, Jianhong Hu, Richard A. Gibbs, Kevin E. Fisher, Juan Carlos Bernini, Jonathan Gill, Timothy C. Griffin, Gail E. Tomlinson, Kelly L. Vallance, Sharon E. Plon
The potential of circulating tumor DNA (ctDNA) analysis to serve as a real-time “liquid biopsy” for children with central nervous system (CNS) and non-CNS solid tumors remains to be fully elucidate...
-
An unusual presentation of bilateral optic pathway glioma in Crouzon Syndrome Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-06-19 Brian Na, Anthony C. Wang, Christopher Travis Watterson, Julian Martinez-Agosto, Sulagna Saitta, Marina Dutra-Clarke, Franceska Bhansali, Stacy L. Pineles, Vivian Y. Chang, Veeral S. Shah, Peter de Blank
Crouzon Syndrome is a genetic craniosynostosis disorder associated with a high risk of ophthalmologic sequelae secondary to structural causes. However, ophthalmologic disorders due to intrinsic ner...
-
Consensus survey on the management of children with chemotherapy-induced febrile neutropenia and at low risk of severe infection Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-06-09 Aude Givone, Jean Duval-Destin, Mathilde Delebarre, Wadih Abou-Chahla, Cyril Lervat, François Dubos
Our aim was to identify national consensus criteria for the management of children with chemotherapy-induced febrile neutropenia (FN), for evidence-based step-down treatment approaches for patients...
-
Innate Immune Mechanism of Neutrophil Extracellular Trap Formation is Impaired in at-Risk Term Low Birth Weight Newborns Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-06-08 Doli Das, Vikas V. Singh, Sudhir K. Chauhan, Richa Rai, Ashok Kumar, Madhu Jain, Geeta Rai
Abstract Low birth weight (LBW) is a leading cause of newborn’s mortality however the underlying defects in cellular immunity and immune mechanisms leading to severe neonatal infections in term LBW (tLBW) newborns are not well understood. Neutrophil extracellular traps (NETs), or NETosis, is an innate immune defense mechanism of neutrophils involved in trapping and killing of microbes. The efficiency
-
Barriers to Accessing Fertility Preservation in Adolescents with Hodgkin Lymphoma in India Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-06-02 Dilpreet Kaur Banwait, Puneet Rana Arora, Amita Mahajan, Veronique Dinand, Sandeep Jain, Manas Kalra, Jagdish Chandra, Ramandeep Singh Arora
Published in Pediatric Hematology and Oncology (Vol. 41, No. 2, 2024)
-
Methotrexate concentrations and associated variability factors in high dose therapy of children with acute lymphoblastic leukemia and non-Hodgkin lymphoma Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-17 Biljana Škorić, Miloš Kuzmanović, Marija Jovanović, Branislava Miljković, Dragan Micić, Milena Jović, Ankica Jovanović, Katarina Vučićević
Abstract Monitoring and optimization procedures improved high dose methotrexate (HDMTX) treatment outcomes. However, there are still some concerns regarding unexplained concentration variability. The objective of this study was to evaluate drug concentrations and associated variability factors in pediatric patients with acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) on HDMTX. Fifty
-
Specific cytokine patterns in Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis compared to Kawasaki disease in children Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-13 Yanli Yang, Hanqing Yu, Chenli Li, Zhen Gui, Yong Chang
Abstract The aim of the study was to test whether the cytokine profile could be used as a marker to differentiate between Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and Kawasaki disease (KD). A total of 70 hospitalized children with HLH and KD admitted to hospital for the first time from March 2017 to December 2021 were enrolled in this study. Fifty-five healthy children
-
An unusual presentation of a pediatric patient with mixed phenotypic acute leukemia with PICALM::MLLT10 gene rearrangement Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-12 Erlyn Smith, Chandra Krishnan
Mixed phenotype leukemia (MPAL) is a rare type of acute leukemia with blasts that co-express antigens of more than one lineage on the same cell or that have separate populations of blasts of differ...
-
Examination of reporting status of pediatric oncology trials within the national library of medicine’s trial database Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-12 Carly Stewart, Kristen McPherson, Liza-Ann Whitaker, Nicholas B. Sajjadi, Randi Kerr, Michael A. Baxter, Micah Hartwell
Finding safer and more effective treatment options are critical in progressing the field of pediatric oncology. These treatment options are discovered through completion and publication of clinical...
-
An unusual case of primary cold agglutinin-associated lymphoproliferative disease in an adolescent female Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-11 Panagiotis Tsarouhas, Melissa Stalling, Carmen Julius, Jeffrey Hord
Published in Pediatric Hematology and Oncology (Vol. 41, No. 1, 2024)
-
Pre-hematopoietic stem cell transplantation lung computed tomography is not an alternative to PFT for pediatric patients with sickle cell disease Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-11 Alexander Ngwube, Angela Garcia, Andrew Ritchey, Lucia Mirea, Sophia Williams, Roberta Adams
Published in Pediatric Hematology and Oncology (Vol. 40, No. 7, 2023)
-
Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-05-02 Satoshi Miyamoto, Kevin Y. Urayama, Yuki Arakawa, Katsuyoshi Koh, Yuki Yuza, Daisuke Hasegawa, Yuichi Taneyama, Yasushi Noguchi, Masakatsu Yanagimachi, Takeshi Inukai, Setsuo Ota, Hiroyuki Takahashi, Dai Keino, Daisuke Toyama, Junko Takita, Daisuke Tomizawa, Tomohiro Morio, Kazutoshi Koike, Koichi Moriwaki, Yuya Sato, Junya Fujimura, Daisuke Morita, Yujin Sekinaka, Kozue Nakamura, Kazuo Sakashita,
Germline genetic variants influence development of pediatric B cell acute lymphoblastic leukemia (B-ALL). Genome-wide association studies (GWAS) have identified several pediatric B-ALL susceptibili...
-
Changes in anthropometrical status and body composition in children with cancer during initial chemotherapy Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-04-24 I. Kellerman, R. Blaauw, J. Schoeman, M. Kruger
Abstract Children with cancer require adequate nutritional support to prevent malnutrition. This study investigated the impact of chemotherapy on anthropometrical status and body composition during the first six months of treatment. Anthropometrical status and body composition were measured at diagnosis, utilizing standardized protocols and validated S10 InBody bio-electrical impedance (BIA) measurements
-
Prevalence of vitamin and iron deficiencies at cancer diagnosis at two pediatric oncology units in South Africa Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-03-20 Judy Schoeman, Ilde-Marié Kellerman, Paul C Rogers, Elena J Ladas, Carl J Lombard, Ronelle Uys, Mariana Kruger
This study investigates the prevalence of vitamin and iron deficiencies at cancer diagnosis. Newly diagnosed children between October 2018 and December 2020 at two South African pediatric oncology ...
-
Treatment outcomes in childhood acute lymphoblastic leukemia: 40-year experience from a single tertiary center in Thailand Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-03-20 Shevachut Chavananon, Pornpun Sripornsawan, Natsaruth Songthawee, Edward B McNeil, Thirachit Chotsampancharoen
Studies on the long-term treatment outcomes of childhood acute lymphoblastic leukemia (ALL) in resource-limited countries are scarce. The purpose of this study was to assess the evolution of surviv...
-
High-dose chemotherapy with autologous stem cell transplantation for patients with extracranial germ cell tumors – experience of two Brazilian pediatric centers Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-03-20 Neysimelia Costa Villela, Adriana Seber, Carla Renata Pacheco Donato Macedo, Victor Gottardello Zecchin, Renata Fittipaldi da Costa Guimarães, Thaíssa Maria Veiga Faria, Daniel Onofre Vidal, Gisele Eiras Martins Jorge, George Navarro, Luiz Fernando Lopes
Abstract Malignant extracranial germ cell tumors (GCTs) are rare in pediatric patients and are usually extremely sensitive to chemotherapy. Relapsed or refractory tumors, although rare, established the need for second-line therapies, including high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT). However, there are few data on its use in children with GCTs. We present a retrospective
-
Growth hormone after CNS tumor diagnosis: the fundamentals, fears, facts, and future directions Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-03-20 Rebecca Ronsley, Margot Lazow, Rohan K. Henry
Growth hormone deficiency (GHD) may occur in pediatric patients with central nervous system (CNS) tumors at initial tumor presentation or later as treatment-related sequelae. While it is well recog...
-
Impact of minimal residual disease on relapse in childhood acute lymphoblastic leukemia: Lessons learnt from a tertiary cancer center in India Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-03-17 Varsha Mishra, Sandeep Jain, Vaneet Anand, Payal Malhotra, Narender Tejwani, Gauri Kapoor
Abstract Prognostic predictive value of end of induction minimal residual disease (EOI-MRD) is well established in acute lymphoblastic leukemia (ALL). We evaluated the factors likely to affect EOI-MRD positivity (>0.01%) by flow cytometry and relapse in different BFM-95 (Berlin–Frankfurt–Munich) risk groups among children and adolescents. In this retrospective study, data of 223 newly diagnosed patients
-
Multicenter real-world experience of the clinical efficacy and tolerance of pazopanib in high-risk pediatric solid tumors (PazoPed) Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-02-24 Meziane Brizini, Lamia Naccache, Pauline Tibout, Catherine Goudie, Crystal Budd, Stéphanie Vairy, Marie-Claude Brisson, Thai Hoa Tran, Raoul Santiago
Abstract Pazopanib, a receptor tyrosine kinase inhibitor, exhibits anti-tumor activity in adult bone and soft-tissue sarcomas (STS), but has not yet been approved for pediatric tumors. The primary objective was to evaluate pazopanib efficacy when used alone or in combination with topotecan. This real-world multicenter retrospective study included patients with solid tumors, aged 25 years or less at
-
Changing recombinant factor VIII to plasma-derived factor VIII during immune tolerance induction Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-02-24 Maíse Moreira Dias, Ricardo Mesquita Camelo, Laura Peixoto de Magalhães, Letícia Lemos Jardim, Andrea Gonçalves de Oliveira, Rosângela de Albuquerque Ribeiro, Vivian Karla Brognoli Franco, Fábia Michelle Rodrigues de Araújo Callado, Cláudia Santos Lorenzato, Suely Meireles Rezende, on behalf of the Brazilian Immune Tolerance (BrazIT) Study group
Published in Pediatric Hematology and Oncology (Vol. 41, No. 1, 2024)
-
Symptomatic osteonecrosis in French survivors of childhood and adolescent leukemia: a clinical and MRI study of LEA cohort Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-02-23 Alice Huault, Gérard Michel, Valérie Charon, Kamal Chouklati, Carine Domenech, Pascal Chastagner, Jean-Hugues Dalle, Catherine Paillard, Stéphane Ducassou, Marilyne Poirée, Geneviève Plat, Marie-Dominique Tabone, Justyna Kanold, André Baruchel, Claire Berger, Isabelle Pellier, Dominique Plantaz, Alexandre Theron, Alaa Mustafa, Pascal Auquier, Virginie Gandemer
Abstract Osteonecrosis (ON) is a known complication of acute leukemia (AL) management, affecting 1%–10% of young patients and resulting in long-term morbidity. Widespread access to MRI over the past decade has allowed earlier detection and more accurate assessment. This study investigated clinical and MRI features of the 129 (2.5%) patients with symptomatic ON retrospectively recruited from the French
-
Multiple synchronous malignancies in an infant with concomitant homozygous BRCA2 and PMS2 mutations with Fanconi anemia phenotype Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-02-02 Hamad Mohammed Alghanim, Mohamed Eltawel, Abdulmajeed Ibrahim Alhaidari, Muhannad Mohammed Alobaid, Areej Mofareh Moghairi, Fahad Sufiani, Naveed Ahmad
Abstract Hereditary cancer predisposition accounts for more than 10% of all cancers in pediatric age group and this is increasingly recognized as an important entity because of modern sequencing techniques. We report a rare association of two concurrent cancer predisposition syndromes, BRCA2 and PMS2, in a young child who presented with concurrent malignancies including Wilms tumor, myelodysplastic
-
Letter to editor regarding “Clinical practice guidelines on management of infantile hemangioma: a systematic quality appraisal using the AGREE II instrument” Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-01-23 Ilona J. Frieden, Anthony J. Mancini, Francine Blei, David H Darrow, Daniel P. Krowchuk
Published in Pediatric Hematology and Oncology (Vol. 40, No. 6, 2023)
-
SACCSG HL-2018. Barriers and enablers of a harmonized treatment protocol for childhood and adolescent Hodgkin lymphoma in South Africa Pediatr. Hematol. Oncol. (IF 1.7) Pub Date : 2023-01-20 Jennifer Geel, Marc Hendricks, Yasmin Goga, Beverley Neethling, Vutshilo Netshituni, Rema Mathew, Johani Vermeulen, Anel van Zyl, Fareed Omar, Jan du Plessis, Liezl du Plessis, Elelwani Madzhia, Thandeka Ngcana, Thanushree Naidoo, Lizette Louw, Daynia E. Ballot, Monika L. Metzger
Abstract Introduction: Collaborative studies have contributed to improved survival of pediatric Hodgkin lymphoma in well-resourced settings, but few are documented in resource-constrained countries. The South Africa Children’s Cancer Study Group initiated harmonization of management protocols in 2015. This article analyzes barriers and enablers of the process. Methods: Clinician-researchers at 11 state-funded