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Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I Chromosoma (IF 1.6) Pub Date : 2024-03-08 Jing-Lian Zhang, Meng-Fei Xu, Jie Chen, Ya-Lan Wei, Zhen-Yu She
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Chromatin organization and behavior in HRAS-transformed mouse fibroblasts Chromosoma (IF 1.6) Pub Date : 2024-02-24 Aoi Otsuka, Katsuhiko Minami, Koichi Higashi, Akane Kawaguchi, Sachiko Tamura, Satoru Ide, Michael J. Hendzel, Ken Kurokawa, Kazuhiro Maeshima
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Maintenance of genome integrity under physical constraints Chromosoma (IF 1.6) Pub Date : 2024-02-15 Evi Soutoglou, Philipp Oberdoerffer
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Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus Chromosoma (IF 1.6) Pub Date : 2024-01-24 Zhen Liang, Ashleigh Solano, Jieqiong Lou, Elizabeth Hinde
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Dicentric chromosomes are resolved through breakage and repair at their centromeres Chromosoma (IF 1.6) Pub Date : 2024-01-02 Diana Cook, Stanislav G. Kozmin, Elaine Yeh, Thomas D. Petes, Kerry Bloom
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DNA replication and replication stress response in the context of nuclear architecture Chromosoma (IF 1.6) Pub Date : 2023-12-06 Daniel González-Acosta, Massimo Lopes
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Karyotypes of water frogs from the Pelophylax esculentus complex: results of cross-species chromosomal painting Chromosoma (IF 1.6) Pub Date : 2023-11-25 Dmitrij Dedukh, Antonina Maslova, Ahmed Al-Rikabi, Niklas Padutsch, Thomas Liehr, Alla Krasikova
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CTCF is essential for proper mitotic spindle structure and anaphase segregation Chromosoma (IF 1.6) Pub Date : 2023-09-20 Katherine Chiu, Yasmin Berrada, Nebiyat Eskndir, Dasol Song, Claire Fong, Sarah Naughton, Tina Chen, Savanna Moy, Sarah Gyurmey, Liam James, Chimere Ezeiruaku, Caroline Capistran, Daniel Lowey, Vedang Diwanji, Samantha Peterson, Harshini Parakh, Ayanna R. Burgess, Cassandra Probert, Annie Zhu, Bryn Anderson, Nehora Levi, Gabi Gerlitz, Mary C. Packard, Katherine A. Dorfman, Michael Seifu Bahiru, Andrew
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H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos Chromosoma (IF 1.6) Pub Date : 2023-09-12 Yakov A. Osipov, Olga V. Posukh, Darya A. Kalashnikova, Polina A. Antoshina, Petr P. Laktionov, Polina A. Skrypnik, Stepan N. Belyakin, Prim B. Singh
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Nucleolin is required for multiple centrosome-associated functions in early vertebrate mitosis Chromosoma (IF 1.6) Pub Date : 2023-08-24 Chandan Kumar, Sivaram V. S. Mylavarapu
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Genome maintenance meets mechanobiology Chromosoma (IF 1.6) Pub Date : 2023-08-15 Vincent Spegg, Matthias Altmeyer
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Cross-species chromosome painting and repetitive DNA mapping illuminate the karyotype evolution in true crocodiles (Crocodylidae) Chromosoma (IF 1.6) Pub Date : 2023-07-26 Vanessa Sales-Oliveira, Marie Altmanová, Václav Gvoždík, Rafael Kretschmer, Tariq Ezaz, Thomas Liehr, Niklas Padutsch, Gabriel Badjedjea, Ricardo Utsunomia, Alongklod Tanomtong, Marcelo Cioffi
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Looping out of control: R-loops in transcription-replication conflict Chromosoma (IF 1.6) Pub Date : 2023-07-07 Charanya Kumar, Dirk Remus
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Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions Chromosoma (IF 1.6) Pub Date : 2023-07-04 Jing Zhu, Qiao Guo, Minjun Choi, Zhoubin Liang, Karen Wing Yee Yuen
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Casting histone variants during mammalian reproduction Chromosoma (IF 1.6) Pub Date : 2023-06-22 Germaine Karam, Antoine Molaro
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Increased genome size is caused by heterochromatin addition in two non-related bat species, Hesperoptenus doriae and Philetor brachypterus (Vespertilionidae, Chiroptera, Mammalia) Chromosoma (IF 1.6) Pub Date : 2023-06-16 Marianne Volleth, Johann Greilhuber, Klaus-Gerhard Heller, Stefan Müller, Hoi-Sen Yong, Josef Loidl
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Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53 Chromosoma (IF 1.6) Pub Date : 2023-05-31 Mai Wang, Steven Phan, Brandon H. Hayes, Dennis E. Discher
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The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6 Chromosoma (IF 1.6) Pub Date : 2023-05-25 Jingtian Guo, Yimeng Wang, Lei Tang, Tiejun Tang, Zhuolan Li, Mengyuan Li, Liming Wang, Aizhong Zeng, Yuxiao Ma, Shihao Huang, Xiaomeng Jiang, Wei Guo
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Modeling of covalent modifications of histones to estimate the binding affinity Chromosoma (IF 1.6) Pub Date : 2023-05-20 Ali Aslhashemi, Mahdi Rezaei Karamati, Hossein Motavalli, Milad Bastami
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Using Synthetic DNA Libraries to Investigate Chromatin and Gene Regulation Chromosoma (IF 1.6) Pub Date : 2023-05-15 Holly Kleinschmidt, Cheng Xu, Lu Bai
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Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors Chromosoma (IF 1.6) Pub Date : 2023-05-11 Sudikchya Shrestha, Masashi Minamino, Zhuo A. Chen, Céline Bouchoux, Juri Rappsilber, Frank Uhlmann
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Regulation of the epigenome through RNA modifications Chromosoma (IF 1.6) Pub Date : 2023-05-04 Emmely A. Patrasso, Sweta Raikundalia, Daniel Arango
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Fluorescence-based super-resolution-microscopy strategies for chromatin studies Chromosoma (IF 1.6) Pub Date : 2023-03-31 Thomas C. Q. Burgers, Rifka Vlijm
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Establishment and inheritance of minichromosomes from Arabidopsis haploid induction Chromosoma (IF 1.6) Pub Date : 2023-03-25 Ek Han Tan, Benny Ordoñez, Tejas Thondehaalmath, Danelle K. Seymour, Julin N. Maloof, Ravi Maruthachalam, Luca Comai
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A cytological revisit on parthenogenetic Artemia and the deficiency of a meiosis-specific recombinase DMC1 in the possible transition from bisexuality to parthenogenesis Chromosoma (IF 1.6) Pub Date : 2023-03-20 Lian-Ying Xu, Wen-Tao Wu, Ning Bi, Zhi-Jun Yan, Fan Yang, Wei-Jun Yang, Jin-Shu Yang
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Are extraordinary nucleosome structures more ordinary than we thought? Chromosoma (IF 1.6) Pub Date : 2023-03-14 Claris Y. Y. Chong, Lu Gan
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The launch of satellite: DNA repeats as a cytogenetic tool in discovering the chromosomal universe of wild Triticeae Chromosoma (IF 1.6) Pub Date : 2023-03-11 Pavel Yu. Kroupin, Daniil S. Ulyanov, Gennady I. Karlov, Mikhail G. Divashuk
Fluorescence in situ hybridization is a powerful tool that enables plant researchers to perform systematic, evolutionary, and population studies of wheat wild relatives as well as to characterize alien introgression into the wheat genome. This retrospective review reflects on progress made in the development of methods for creating new chromosomal markers since the launch of this cytogenetic satellite
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A genome-wide RNAi screen for genes important for proliferation of cultured Drosophila cells at low temperature identifies the Ball/VRK protein kinase Chromosoma (IF 1.6) Pub Date : 2023-02-07 Anna Mendaluk, Emmanuel Caussinus, Michael Boutros, Christian F. Lehner
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Sex-chrom v. 2.0: a database of green plant species with sex chromosomes Chromosoma (IF 1.6) Pub Date : 2023-02-02 Sònia Garcia, Bohuslav Janousek, Joan Pere Pascual-Díaz, Susanne S. Renner
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Super-resolution microscopy reveals the number and distribution of topoisomerase IIα and CENH3 molecules within barley metaphase chromosomes Chromosoma (IF 1.6) Pub Date : 2023-01-31 Ivona Kubalová, Klaus Weisshart, Andreas Houben, Veit Schubert
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A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes Chromosoma (IF 1.6) Pub Date : 2023-01-17 Karen Jule Nieken, Kathryn O’Brien, Alexander McDonnell, Liudmila Zhaunova, Hiroyuki Ohkura
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A step forward in the genome characterization of the sugarcane borer, Diatraea saccharalis: karyotype analysis, sex chromosome system and repetitive DNAs through a cytogenomic approach Chromosoma (IF 1.6) Pub Date : 2022-10-11 Ana E. Gasparotto, Diogo Milani, Emiliano Martí, Ana Beatriz S. M. Ferretti, Vanessa B. Bardella, Frederico Hickmann, Magda Zrzavá, František Marec, Diogo C. Cabral-de-Mello
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Cytogenetic status of patients with congenital malformations or suspected chromosomal abnormalities in Turkey: a comprehensive cytogenetic survey of 11,420 patients Chromosoma (IF 1.6) Pub Date : 2022-10-11 Osman Demirhan, Erdal Tunç
Cytogenetic analysis is helpful in diagnostic workup of patients having prenatal or early postnatal medical problems and provides a basis for genetic counseling or deciding on clinical treatment options. Chromosomal abnormalities (CAs) constitute one of the most important category of genetic defects which have the potential to cause irreversible disorders. In this study, chromosome analysis results
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Comparison of the somatic TADs and lampbrush chromomere-loop complexes in transcriptionally active prophase I oocytes Chromosoma (IF 1.6) Pub Date : 2022-08-29 Tatiana Kulikova, Antonina Maslova, Polina Starshova, Juan Sebastian Rodriguez Ramos, Alla Krasikova
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Genome characterization and CRISPR-Cas9 editing of a human neocentromere Chromosoma (IF 1.6) Pub Date : 2022-08-17 Antonio Palazzo, Ilaria Piccolo, Crescenzio Francesco Minervini, Stefania Purgato, Oronzo Capozzi, Pietro D’Addabbo, Cosimo Cumbo, Francesco Albano, Mariano Rocchi, Claudia Rita Catacchio
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Time to match; when do homologous chromosomes become closer? Chromosoma (IF 1.6) Pub Date : 2022-08-12 M. Solé, J. Blanco, D. Gil, O. Valero, B. Cárdenas, G. Fonseka, E. Anton, Á. Pascual, R. Frodsham, F. Vidal, Z. Sarrate
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Transcription factor Sp1 regulates mitotic chromosome assembly and segregation Chromosoma (IF 1.6) Pub Date : 2022-08-02 Samuel Flashner, Michelle Swift, Aislinn Sowash, Alexander N. Fahmy, Jane Azizkhan-Clifford
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The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases Chromosoma (IF 1.6) Pub Date : 2022-07-30 Hadeel T. Zedan, Fatma H. Ali, Hatem Zayed
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Migration of repetitive DNAs during evolution of the permanent translocation heterozygosity in the oyster plant (Tradescantia section Rhoeo) Chromosoma (IF 1.6) Pub Date : 2022-07-27 Hieronim Golczyk, Eva Hřibová, Jaroslav Doležel, Ángeles Cuadrado, Frauke Garbsch, Stephan Greiner, Monika Janeczko, Marek Szklarczyk, Maciej Masłyk, Konrad Kubiński
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Allele segregation analysis of F1 hybrids between independent Brassica allohexaploid lineages Chromosoma (IF 1.6) Pub Date : 2022-05-05 Daniela Quezada-Martinez, Jun Zou, Wenshan Zhang, Jinling Meng, Jacqueline Batley, Annaliese S. Mason
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Life of double minutes: generation, maintenance, and elimination Chromosoma (IF 1.6) Pub Date : 2022-04-30 Mila Ilić, Irene C. Zaalberg, Jonne A. Raaijmakers, René H. Medema
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Kinesin-5 Eg5 mediates centrosome separation to control spindle assembly in spermatocytes Chromosoma (IF 1.6) Pub Date : 2022-04-18 Zhen-Yu She, Ning Zhong, Ya-Lan Wei
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Germline-restricted chromosome shows remarkable variation in size among closely related passerine species Chromosoma (IF 1.6) Pub Date : 2022-04-07 Manuelita Sotelo-Muñoz, Manon Poignet, Tomáš Albrecht, Ondřej Kauzál, Dmitrij Dedukh, Stephen A. Schlebusch, Karel Janko, Radka Reifová
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Multiple heterochromatin diversification events in the genome of fungus-farming ants: insights from repetitive sequences Chromosoma (IF 1.6) Pub Date : 2022-03-24 Gisele Amaro Teixeira, Luísa Antônia Campos Barros, Hilton Jeferson Alves Cardoso de Aguiar, Denilce Meneses Lopes
A substantial portion of the eukaryotic genome includes repetitive DNA, which is important for its stability, regulation, and architecture. Fungus-farming ant genomes show remarkable structural rearrangement rates that were necessary for the establishment of their agriculture-based lifestyle, highlighting the relevance of this peculiar group in understanding the repetitive portion of ant genome. Chromosomal
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The N-terminal domain of TET1 promotes the formation of dense chromatin regions refractory to transcription Chromosoma (IF 1.6) Pub Date : 2022-03-02 Audrey Lejart, Siham Zentout, Catherine Chapuis, Ostiane D’Augustin, Rebecca Smith, Gilles Salbert, Sébastien Huet
TET (ten-eleven translocation) enzymes initiate active cytosine demethylation via the oxidation of 5-methylcytosine. TET1 is composed of a C-terminal domain, which bears the catalytic activity of the enzyme, and a N-terminal region that is less well characterized except for the CXXC domain responsible for the targeting to CpG islands. While cytosine demethylation induced by TET1 promotes transcription
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Satellitome analysis illuminates the evolution of ZW sex chromosomes of Triportheidae fishes (Teleostei: Characiformes) Chromosoma (IF 1.6) Pub Date : 2022-01-31 Rafael Kretschmer, Caio Augusto Gomes Goes, Luiz Antônio Carlos Bertollo, Tariq Ezaz, Fábio Porto-Foresti, Gustavo Akira Toma, Ricardo Utsunomia, Marcelo de Bello Cioffi
Satellites are an abundant source of repetitive DNAs that play an essential role in the chromosomal organization and are tightly linked with the evolution of sex chromosomes. Among fishes, Triportheidae stands out as the only family where almost all species have a homeologous ZZ/ZW sex chromosomes system. While the Z chromosome is typically conserved, the W is always smaller, with variations in size
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NucPosDB: a database of nucleosome positioning in vivo and nucleosomics of cell-free DNA Chromosoma (IF 1.6) Pub Date : 2022-01-21 Mariya Shtumpf, Kristan V. Piroeva, Shivam P. Agrawal, Divya R. Jacob, Vladimir B. Teif
Nucleosome positioning is involved in many gene regulatory processes happening in the cell, and it may change as cells differentiate or respond to the changing microenvironment in a healthy or diseased organism. One important implication of nucleosome positioning in clinical epigenetics is its use in the “nucleosomics” analysis of cell-free DNA (cfDNA) for the purpose of patient diagnostics in liquid
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Incorporation of CENP-A/CID into centromeres during early Drosophila embryogenesis does not require RNA polymerase II–mediated transcription Chromosoma (IF 1.6) Pub Date : 2022-01-11 Samadri Ghosh, Christian F. Lehner
In many species, centromere identity is specified epigenetically by special nucleosomes containing a centromere-specific histone H3 variant, designated as CENP-A in humans and CID in Drosophila melanogaster. After partitioning of centromere-specific nucleosomes onto newly replicated sister centromeres, loading of additional CENP-A/CID into centromeric chromatin is required for centromere maintenance
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The extensive amplification of heterochromatin in Melipona bees revealed by high throughput genomic and chromosomal analysis Chromosoma (IF 1.6) Pub Date : 2021-11-26 Pereira, Jaqueline A., Milani, Diogo, Ferretti, Ana Beatriz S. M., Bardella, Vanessa B., Cabral-de-Mello, Diogo C., Lopes, Denilce M.
Satellite DNAs (satDNAs) and transposable elements (TEs) are among the main components of constitutive heterochromatin (c-heterochromatin) and are related to their functionality, dynamics, and evolution. A peculiar case regarding the quantity and distribution of c-heterochromatin is observed in the genus of bees, Melipona, with species having a low amount of heterochromatin and species with high amount
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Heterologous synapsis in C. elegans is regulated by meiotic double-strand breaks and crossovers Chromosoma (IF 1.6) Pub Date : 2021-10-04 Liu, Hanwenheng, Gordon, Spencer G., Rog, Ofer
Alignment of the parental chromosomes during meiotic prophase is key to the formation of genetic exchanges, or crossovers, and consequently to the successful production of gametes. In almost all studied organisms, alignment involves synapsis: the assembly of a conserved inter-chromosomal interface called the synaptonemal complex (SC). While the SC usually synapses homologous sequences, it can assemble
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The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival Chromosoma (IF 1.6) Pub Date : 2021-07-31 Steffen, Philipp A., Altmutter, Christina, Dworschak, Eva, Junttila, Sini, Gyenesei, Attila, Zhu, Xinzhou, Kockmann, Tobias, Ringrose, Leonie
The Drosophila Trithorax group (TrxG) protein ASH1 remains associated with mitotic chromatin through mechanisms that are poorly understood. ASH1 dimethylates histone H3 at lysine 36 via its SET domain. Here, we identify domains of the TrxG protein ASH1 that are required for mitotic chromatin attachment in living Drosophila. Quantitative live imaging demonstrates that ASH1 requires AT hooks and the
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Anatomy and evolution of a DNA replication origin Chromosoma (IF 1.6) Pub Date : 2021-07-12 Yutaka Yamamoto, Eric A. Gustafson, Michael S. Foulk, Heidi S. Smith, Susan A. Gerbi
DNA amplification occurs at the DNA puff II/9A locus in the fungus fly Sciara coprophila. As a foundation to study the molecular mechanism for the initiating events of II/9A DNA re-replication, we have sequenced 14 kb spanning a DNase hypersensitive site (DHS) upstream of the 1 kb amplification origin and through transcription units II/9–1 and II/9–2 downstream of the origin. These elements are annotated
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Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation and meiotic sex chromosome inactivation Chromosoma (IF 1.6) Pub Date : 2021-07-06 M. Solé, J. Blanco, D. Gil, O. Valero, Á. Pascual, B. Cárdenas, G. Fonseka, E. Anton, R. Frodsham, F. Vidal, Z. Sarrate
Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence
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Unravelling HP1 functions: post-transcriptional regulation of stem cell fate Chromosoma (IF 1.6) Pub Date : 2021-06-15 Assunta Maria Casale, Ugo Cappucci, Lucia Piacentini
Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein first identified in Drosophila as a major component of constitutive heterochromatin, required for stable epigenetic gene silencing in many species including humans. Over the years, several studies have highlighted additional roles of HP1 in different cellular processes including telomere maintenance, DNA replication and repair, chromosome
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Interphase epichromatin: last refuge for the 30-nm chromatin fiber? Chromosoma (IF 1.6) Pub Date : 2021-06-05 Peng Xu, Julia Mahamid, Marco Dombrowski, Wolfgang Baumeister, Ada L. Olins, Donald E. Olins
“Interphase epichromatin” describes the surface of chromatin located adjacent to the interphase nuclear envelope. It was discovered in 2011 using a bivalent anti-nucleosome antibody (mAb PL2-6), now known to be directed against the nucleosome acidic patch. The molecular structure of interphase epichromatin is unknown, but is thought to be heterochromatic with a high density of “exposed” acidic patches
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BAC- and oligo-FISH mapping reveals chromosome evolution among Vigna angularis , V. unguiculata , and Phaseolus vulgaris Chromosoma (IF 1.6) Pub Date : 2021-04-28 Lívia do Vale Martins, Fernanda de Oliveira Bustamante, Ana Rafaela da Silva Oliveira, Antônio Félix da Costa, Lidiane de Lima Feitoza, Qihua Liang, Hainan Zhao, Ana Maria Benko-Iseppon, María Muñoz-Amatriaín, Andrea Pedrosa-Harand, Jiming Jiang, Ana Christina Brasileiro-Vidal
Cytogenomic resources have accelerated synteny and chromosome evolution studies in plant species, including legumes. Here, we established the first cytogenetic map of V. angularis (Va, subgenus Ceratotropis) and compared this new map with those of V. unguiculata (Vu, subgenus Vigna) and P. vulgaris (Pv) by BAC-FISH and oligopainting approaches. We mapped 19 Vu BACs and 35S rDNA probes to the 11 chromosome
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Linear elements are stable structures along the chromosome axis in fission yeast meiosis Chromosoma (IF 1.6) Pub Date : 2021-04-07 Da-Qiao Ding, Atsushi Matsuda, Kasumi Okamasa, Yasushi Hiraoka
The structure of chromosomes dramatically changes upon entering meiosis to ensure the successful progression of meiosis-specific events. During this process, a multilayer proteinaceous structure called a synaptonemal complex (SC) is formed in many eukaryotes. However, in the fission yeast Schizosaccharomyces pombe, linear elements (LinEs), which are structures related to axial elements of the SC, form
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Sex differences in the meiotic behavior of an XX sex chromosome pair in males and females of the mole vole Ellobius tancrei : turning an X into a Y chromosome? Chromosoma (IF 1.6) Pub Date : 2021-04-06 Ana Gil-Fernández, Sergey Matveevsky, Marta Martín-Ruiz, Marta Ribagorda, María Teresa Parra, Alberto Viera, Julio S. Rufas, Oxana Kolomiets, Irina Bakloushinskaya, Jesús Page
Sex determination in mammals is usually provided by a pair of chromosomes, XX in females and XY in males. Mole voles of the genus Ellobius are exceptions to this rule. In Ellobius tancrei, both males and females have a pair of XX chromosomes that are indistinguishable from each other in somatic cells. Nevertheless, several studies on Ellobius have reported that the two X chromosomes may have a differential