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An isolated sacral promyelocytic sarcoma in a child: A rare case report with emphasis on cytomorphology Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-17 Jeongeun Do, Talal Arshad, Juanita Emily Ferreira, Leonard Nsoyori Yenwongfai, Hafsa Nebbache, Derek Blake Allison, Dava West Piecoro, Melissa Vandyke Kesler
Myeloid sarcoma (MS) is an uncommon localized extramedullary tumor composed of immature myeloid precursor cells that can affect any organ. Promyelocytic sarcoma (PS), an extremely rare subtype of MS, is characterized by immature myeloid cells with features of acute promyelocytic leukemia (APL). We describe a case of pediatric PS that presented as a solitary sacral mass without any evidence of systemic
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Comments on “diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda category III in an endemic region” Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-16 Archit Goel, Gargi Kapatia, Shruti Gupta, Vikasdeep Gupta, Shivani Sidana
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Solitary fibrous tumor of deep parotid gland preoperatively classified as salivary gland neoplasm of uncertain malignant potential by the Milan system for reporting salivary gland cytopathology: A common diagnosis for a rare entity Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-16 Hamza Numan Gokozan, Theresa Scognamiglio
Solitary fibrous tumor (SFT) is a rare fibroblastic tumor with spindle cell morphology, which is characterized by a prominent branching vasculature and a NAB2‐STAT6 gene rearrangement. SFT may occur in any anatomical site and may involve salivary glands, including the parotid gland. We present a young female with a primary parotid SFT diagnosed as “neoplasm—Salivary gland neoplasm of uncertain malignant
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The American Board of Pathology cytopathology board examination: Personal recollections of the first cytopathology board exam and a brief historical perspective Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-13 George G. Birdsong
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Endometrial cytological findings for a mesonephric‐like endometrial adenocarcinoma: A case report Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-08 Hirotaka Omine, Kazuyuki Ishida, Natsuki Sasaki, Hikaru Kato, Tamiko Nagai, Mihoko Ishikawa, Mina Takaoka, Shuhei Noda, Hadzki Matsuda, Akira Mitsuhashi
A mesonephric‐like endometrial adenocarcinoma (ML‐EAC) is very rare and has a worse prognosis than other endometrial carcinomas. We describe an ML‐EAC and report our endometrial cytological findings. A 76‐year‐old woman presented with irregular genital bleeding and a uterine mass. Endometrial cytology revealed atypical cylindrical or spindle‐shaped cells in the form of small aggregates or solitary
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A case of lung FNA with atypical squamous cells Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-04 Timothy Leif Helland, Vanda F. Torous
Fine‐needle aspiration (FNA) is a commonly employed method for initial diagnosis and work‐up of pulmonary nodules. Utilization of rapid on‐site evaluation (ROSE) has the added benefit of allowing for triaging of material as appropriate for ancillary studies including microbiology testing. While many pulmonary lesions are easily categorized by cytologic evaluation, more difficult cases exist. In particular
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Unveiling lipid‐rich (“clear cell”) pancreatic neuroendocrine tumor: A small series of two cases with literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-01 Rong Xia, Laura H. Tang, Negin Shafizadeh, Yue Xue, Xiaoying Liu
This study presents two cases of lipid‐rich pancreatic neuroendocrine tumors (PanNETs), a rare variant posing significant diagnostic challenges in fine needle aspiration (FNA) cytology and small biopsies. The first case involves an elderly male with a pancreatic tumor, displaying distinct cytoplasmic vacuoles, while the second case is a middle‐aged male present with a pancreatic tail mass exhibiting
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Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-28 Wei Zhang, Jianyuan Lei, Jie Chen, Wensheng Li
BackgroundFine‐needle aspiration (FNA) is the most commonly used preoperative pathological diagnostic tool for thyroid tumors. Secondary malignant tumors of the thyroid gland account for less than 3% of all thyroid malignancies. The aim of this study was to investigate the types and cytopathological features of secondary thyroid tumors, evaluate diagnostic pitfalls in FNA.MethodsCases of secondary
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Case of lung fine needle aspiration showing mucinous cells and extracellular mucin Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-27 Maelle Saliba, Marie C. Smithgall, Anjali Saqi, John P Crapanzano, Simon Sung
Mucinous neoplasm with extracellular mucin can be challenging to interpret on fine needle aspiration and core biopsies. Determining the biologic origin of the mucin/mucinous cells, that is, benign/incidental versus neoplasm, invasive versus in situ, and primary versus metastatic tumors, requires a thorough multidisciplinary evaluation. The work up of these lesions includes morphologic analysis with
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Metastatic upper tract urothelial carcinoma with nest-like features presenting as malignant pleural effusion Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-23 Francesca Arienzo, Alessandra Valenti, Paolo Ricci, Valeria Ascoli
Metastatic urothelial carcinoma is a rare cause of pleural effusions. We report a case of urothelial carcinoma of the upper urinary tract in an oldest-old male patient, a smoker, with situs inversus totalis, that presented uniquely with malignant pleural effusion at presentation without evidence of a primary tumor on imaging. Cytological smears of the massive left pleural effusion revealed epithelioid
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Gastrointestinal stromal tumors in fine-needle aspiration biopsies Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-23 Seyedreza Mousavi, Yuho Ono, Paul A. VanderLaan, Yaileen D. Guzmán-Arocho
Gastrointestinal stromal tumors (GISTs), although rare, are the most common mesenchymal neoplasms of the gastrointestinal tract. Their potential for malignancy underscores the significance of identifying them through cytomorphologic findings and pertinent immunohistochemical markers. GISTs can emerge anywhere along the gastrointestinal tract with a predilection for the stomach. The clinical manifestations
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Cytomorphology of metastatic dedifferentiated/undifferentiated melanoma to the gallbladder: A case report and review of literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-21 Shaymaa Hegazy, Zarine Kamaluddin, Rana Naous
Dedifferentiated/undifferentiated melanoma (DM/UM) is a distinct subtype of malignant melanoma that tends to lose all melanocytic markers of differentiation. DM/UM pose major diagnostic challenges as they could be easily confused with UM sarcoma or carcinoma, thus necessitating the use of molecular studies such as Next Generation Sequencing (NGS) for detecting melanoma‐compatible mutations to confirm
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Are there specific cytologic features that can predict BRAFV600E mutational status of papillary thyroid carcinoma in fine‐needle aspiration specimens? Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-19 Juliann M. Mendes, Tarik M. Elsheikh, Jessica Di Marco, Jennifer Russell, Tatyana Gladkaya, Marlo M. Nicolas, Elisha Clapacs, James F. Bena, John L. McAfee, Maria Luisa C. Policarpio‐Nicolas
BackgroundBRAFV600E mutation is the most common molecular alteration found in papillary thyroid carcinoma (PTC) and has been linked to recurrent disease or possibly more aggressive behavior. Some studies have reported sickle‐shaped nuclei (SSN) and plump pink cells (PPC) to be predictive markers of BRAF mutation in FNA cytology. We aimed to evaluate the reproducibility of the aforementioned cytologic
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Calcium oxalate crystals in pulmonary aspergillosis Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-17 Gonçalo Martins Pereira, Miguel Cristóvão, Eugénia Dvindenko, Carla Pinheiro, Maria Manuel Lemos, Saudade André
CONFLICT OF INTEREST STATEMENT None of the authors have conflicts of interest to declare.
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Myxoid neurofibroma masquerading as lymphatic-venous malformation and poses a diagnostic challenge on fine needle aspiration biopsy Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-16 Nada Shaker, Hans Iwenofu, Nuha Shaker, Zofia Tynski, Omar P. Sangueza, Abdul Abid
Myxoid neurofibromas (NF) are uncommon, benign spindle cell tumors that originate from peripheral nerve sheaths, often posing a diagnostic challenge due to their hypocellularity on cytology specimens. Distinguishing myxoid spindle cell lesions can be challenging, given the broad range of potential differential diagnoses.
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Fungal infection mimicking soft tissue lesion: Role of on-site evaluation, special stain, and cellblock Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Santosh Tummidi, Micheal Leonard Anthony, Jarang Rajesh Kumar, Arundhathi Shankaralinagappa, Naresh Kumar Pannerselvam, Prudhvinath A Reddy, Pavithra Balakrishna
Fine-needle aspiration (FNA) cytology is a basic diagnostic method used for the investigation of superficial and deep lesions. The implementation of rapid on-site evaluation (ROSE) in cytological analysis can help in reducing the inadequacy rate and obtaining proper samples for further tests/analysis.
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Insufficient endobronchial ultrasound-guided transbronchial needle aspiration specimens. When and why? The analysis of criteria and reasons behind the insufficient specimens Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Antti Vuorisalo, Heini Huhtala, Timo Paavonen, Ivana Kholová
The classification terminology systems for pulmonary cytology specimens have recently emerged. Inadequate samples, classified as "nondiagnostic," raise challenges in determining the threshold of cell numbers and the risk of malignancy (ROM).
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Fusion of old and new: Employing touch imprint slides for next generation sequencing in solid tumors Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-09 Cisel Aydin Mericoz, Ozgur Can Eren, Ibrahim Kulac, Pinar Firat
Cytomorphological evaluation of tissue touch imprints during rapid on-site evaluation or intraoperative pathology consultation has crucial value. However, literature on their utility for molecular testing is limited. In this study, we emphasize a further benefit of touch imprint slides and scrutinize our institutional experience on their use in molecular testing, specifically next generation sequencing
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COVID and cytopathology training: Impact and innovations Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-07 Kasturi Das
Graduate medical education and training in Cytopathology faced numerous unexpected challenges during the COVID-19 pandemic of 2020. It was caused by the SARS-Co-V2 coronavirus and transmitted by breathing droplets or aerosol particles containing the virus and less commonly by contact with infected surfaces and fomites. To mitigate the rapid spread of disease non-essential services were closed, surgical
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Cytotechnology schools: Future outlook Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-03 Lois Rockson
Recent changes in the standard and guidelines governing the education of cytotechnologists herald in a new era of cytology education. The long-discussed move to master level education and name change of the professional to cytologist signifies an alignment with current and projected scope of mid-level diagnostic cytology practice. Cytotechnology programs going forward are charged with implementing
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Trichilemmal carcinoma metastatic to parotid gland: First report of fine needle aspiration cytology features Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-29 Priya Jayakumar, Aanchal Kakkar, Sudheer Arava, Supriya Mallick
Trichilemmal carcinoma is a rare malignant cutaneous adnexal neoplasm arising from the outer root sheath of the hair follicle. Majority of cases occur on sun-exposed sites such as the face, scalp and neck, making them easily amenable to being biopsied and subjected to histological examination for definitive diagnosis. Thus, cytological features of trichilemmal carcinoma have not been described till
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Endometriosis first presenting in pleural fluid cytology Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-30 Heather I. Chen-Yost, Tao Huang, Kathleen O'Brien, William Weir, Rishindra M. Reddy, Richard Lieberman, Judy Pang
Most patients with thoracic endometriosis present with catamenial pneumothorax, a rare condition in which recurrent episodes occur within 72 h before or after the start of menstruation. We report a case of thoracic endometriosis presenting with recurrent bloody pleural effusions without pneumothorax diagnosed on pleural fluid cytology. We describe the cytomorphology and immunoprofile of thoracic endometriosis
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Diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda Category III in an endemic region Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-25 Zeliha Aydın Kasap, Burçin Kurt, Elif Özsağır, Mustafa Emre Ercin, Ali Güner
This study aims to develop a diagnostic model to help physicians determine whether thyroid nodules categorized as atypia of undetermined significance (AUS) in category III of the Bethesda system are benign or malignant preoperatively. To create a diagnostic model for predicting thyroid nodules' benign or malignant with AUS cytology based on clinical, ultrasonographic, and cytopathological findings
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The detection of PD-L1 expression on liquid-based cytology in pleural effusion of lung adenocarcinoma and its prognostic evaluation: Between paired liquid-based cytology and cell block samples Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-23 Haiyue Ma, Jia Jia, Zihan Sun, Xiaoyue Xiao, Shuo Liang, Linlin Zhao, Zhihui Zhang
Programmed death-ligand 1 (PD-L1) expression levels measured by immunohistochemistry have been proven to predict the outcome of immunotherapy in lung adenocarcinoma (LUAD). However, data on PD-L1 expression on liquid-based cytology (LBC) in malignant pleural effusion (MPE) is scarce.
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Rapid on-site evaluation improves diagnostic performance of fine-needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-23 Manbin Xu, Lifei Deng, Kunpeng Peng, Xiaolong Wei, Mei Xie, Muyuan Liu, Hanwei Peng
To evaluate the diagnostic performance of Milan system for reporting salivary gland cytopathology (MSRSGC) in two southern China tertiary cancer centers and investigate the impact of rapid on-site evaluation (ROSE) on FNAC performance.
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Investigation of MTAP and BAP1 staining loss and P16/CDKN2A deletion in pleural cytology specimens and its role in the diagnosis of mesothelioma Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-20 Nazli Sena Şeker, Emel Tekin, Güntülü Ak, Muzaffer Metintaş, Selma Metintaş, Emine Dündar
Mesothelioma is a malignant neoplasm with a poor survival rate. We aimed to investigate the importance of BAP1, MTAP (IHC), and p16/CDKN2A homozygous deletion (FISH) in cytologic material obtained from pleural effusion sampling, which is a less invasive procedure in the diagnosis of mesothelioma.
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Cytohistological findings and diagnostic challenges in rare pediatric pulmonary mesenchymal malignancies: A report of two cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-18 Karunagaran Balaji, Swalaha Sadaf Siddique, Ujjawal Khurana, Garima Goel, Ashwani Tandon, Deepti Joshi, Narendra Chaudhary, Alkesh Kumar Khurana, Abhishek Goyal
Pulmonary mesenchymal tumors are uncommon neoplasms and the data available on their clinical, cytohistomorphological, immunohistochemical, and molecular findings are limited, leading to difficulty in timely diagnosis and management. Case 1: A 12-year-old boy presented with a right endobronchial mass. Imprint smears from endobronchial biopsy revealed moderately pleomorphic spindle cell tumor arranged
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Fine needle aspiration of spindle cell lipoma—Lochkern cells as a clue for diagnosis: A case arising in the parotid gland Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-12 Mana Taweevisit, Paul Scott Thorner
Spindle cell lipoma (SCL) is a rare form of lipoma, typically occurring as a mass in the back, shoulder or posterior neck of adult males. Most cases present little diagnostic difficulty on fine needle aspiration (FNA), but can be problematic when the SCL is in an unusual location. The authors report a case in the parotid gland in a 75-year-old man. FNA was paucicellular and showed loose collections
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Cytomorphological comparison of ThinPrep and SurePath liquid-based cytology in thyroid fine-needle aspiration Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-12 Wen-Ying Lee, Hsiu-Chu Wang, Kai-Jen Tien
The two widely established systems for liquid-based cytology (LBC), ThinPrep and SurePath, employ different principles. The aim of this study was to compare the cytomorphology of thyroid lesions prepared by the two techniques.
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A comparison between conventional and the Paris systems of reporting urinary cytopathology with a literature update Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-02 Narasimhapriyan Kannan, Debasis Gochhait, Manikandan Ramanitharan, Neelaiah Siddaraju
Owing to certain inherent limitations of earlier reporting systems, “The Paris System for Reporting Urinary Cytology (TPS)” was implemented in 2015 to standardize reporting urine cytology with more stringent cytomorphologic criteria. We share our post-TPS experience, comparing it with the conventional system (CS).
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Gastric-type adenocarcinoma of the uterine cervix presenting in urine cytology specimens: A case report and literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-22 Kyung-Hwa Lee, Nah Ihm Kim, Jong-Hee Nam, Sung Sun Kim
Gastric-type endocervical adenocarcinoma (GEA) is a rare type adenocarcinoma of the uterine cervix that is unrelated to human papillomavirus (HPV). GEA is difficult to diagnose due to its bland-looking morphological characteristics and is therefore often underdiagnosed. Although abnormal cells may be seen on cervical cytology specimens, they are rarely diagnosed as malignant and are often classified
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Performance of non-formalin fixed paraffin embedded samples in hybrid capture and amplicon next-generation sequencing panels Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-20 Sibele Inácio Meireles, Mariana Vargas Cruz, Carla Daniele de Godoy, Leonardo de Testagrossa
Genomic profiling using next-generation sequencing (NGS) is fundamental for driving prognostic and therapy in cancer. Formalin-fixed paraffin embedded (FFPE) tissue is the widely used material, whereas non-FFPE may represent an alternative. However, studies comparing the NGS performance of non-FFPE materials to FFPE are still lacking in the literature. The objective of this study was to characterize
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Disseminated thymoma in pleural fluid: An unusual case Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-16 Kate Berry, Caroline Cooper
Thymic epithelial tumours show characteristic cytological features on fine-needle aspiration cytology, however the cytological features of thymoma in fluid cytology are not well described. We present the case of a 77 year-old-woman with known pleural dissemination of type B2/B3 thymoma presenting with shortness of breath and orthopnoea due to a pleural effusion. Cytological evaluation of the pleural
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PD-L1 expression in fine-needle aspiration cell blocks of head and neck squamous-cell carcinoma and its cytohistological concordance Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-14 Sandy Si Kei Lou, Heather Ruff, Scott MacDonald, Stephen M. Smith, Carol C. Cheung
PD-L1 immunoexpression in head and neck squamous-cell carcinoma (HNSCC) determines immunotherapy eligibility. Patients are often diagnosed using fine-needle aspiration (FNA) of metastatic lymph nodes, however, the cytohistologic correlation of the combined positive score (CPS) is largely unknown.
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Two-tier subclassification of the Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) in thyroid cytology Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-14 Jay Alden, Denise Lambrou, Jack Yang
The Bethesda category III, AUS/FLUS, comprises a heterogeneous group of thyroid lesions with variable risk of malignancy (ROM). This study evaluates ROM in two subgroups of this category based on nuclear atypia and architectural atypia.
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Acantholytic squamous cell carcinoma mimicking epithelioid angiosarcoma: A diagnostic challenge by cytology Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-09 Mana Taweevisit, Piriya Sutthiruangwong, Paul Scott Thorner
Squamous cell carcinoma (SCC) is the most common malignancy of the head and neck region. Most cases present little diagnostic difficulty on fine needle aspiration (FNA), but unusual variants can be problematic. The authors report a case of the acantholytic SCC of the oral cavity in a 36-year-old male. The FNA showed hypercellularity, with malignant cells arranged in isolation, loosely cohesive groups
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Bilateral intra-lymph node Warthin's tumor as a potential diagnostic pitfall mimicking metastatic carcinoma Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-07 Ana Lívia Santos-Sousa, Deolino João Camilo-Júnior, Sebastião Conrado-Neto, Daniel Galera Bernabé, Jose Candido C. Xavier-Júnior
Warthin's tumor (WT) is a benign and frequent salivary gland tumor primarily affecting the parotid gland. In some cases, this tumor can involve the extra parotid region and affect cervical lymph nodes. Fine-needle aspiration can be the first step in the diagnostic approach to lymphadenopathy; however, specimens from intra-nodal WT can present a potential pitfall, leading to a misdiagnosis of metastasis
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Decoding the rhabdoid riddle in liver: A rare case of primary hepatic malignant rhabdoid tumor with a comprehensive literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-07 Aadya Kerkar, Parikshaa Gupta, Ajmeera Azeez, Anmol Bhatia, Nalini Gupta, Deepak Bansal
Malignant rhabdoid tumor of the liver is a rare, highly aggressive primary hepatic malignancy occurring primarily in infants. Establishing a definitive diagnosis is challenging due to its rarity, non-specific clinicoradiologic findings, and overlapping morphologic features. Herein, we present the cytomorphologic and immunocytochemical characteristics of a rare case of primary hepatic Malignant rhabdoid
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The WHO system versus the Papanicolaou society of cytopathology system for reporting pancreaticobiliary cytology for risk stratification—which is better? Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-07 Reetu Kundu, Arpitha Kollabathula, Nalini Gupta, Manish Rohilla, Surinder Singh Rana, Ritambhra Nada, Naveen Kalra, Rajender Kumar Basher, Parikshaa Gupta, Pranab Dey, Rajesh Gupta, Usha Dutta, Radhika Srinivasan
Recently, the World Health Organization (WHO) has proposed a reporting system for pancreaticobiliary cytopathology. We applied this classification for pancreatic lesion samples by fine needle aspiration (FNA) and compared the results to the previous classification of the Papanicolaou Society of Cytopathology (PSC) system for risk stratification.
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Opportunistic microsporidiosis unveiled by fine-needle aspiration cytology of cervical lymph node with literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-07 Brijdeep Singh, Reetu Kundu, Chayan Sharma, Sumeeta Khurana, Harish Bhujade, Neeraj Singla, Shivaprakash M. Rudramurthy
Microsporidia are highly specialized obligate intracellular organisms closely related to fungi, traditionally linked to diarrheal diseases in acquired immunodeficiency syndrome patients. Over the past two decades, an increasing incidence of extraintestinal infections affecting various organ systems, especially in immunocompromised individuals, has been observed. The report presents a unique case of
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Diagnosis of peritoneal metastasis in an unruptured hepatocellular carcinoma on ascitic fluid cytology: A rare scenario with brief review of literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-30 Syed Saad Salman, Balamurugan Thirunavukkarasu, Rajni Yadav, Vishal Singh Chauhan, Raja Shekar Peddinti, Shalimar, Shivanand Gamanagatti
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults occurring in a background of cirrhosis. Peritoneal dissemination of HCC is an unusual presentation with an incidence of 2%–16%. Peritoneal metastasis of an unruptured HCC is extremely uncommon. Despite low yield, ascitic fluid cytology serves as a valuable tool for diagnostic evaluation in a patient of cirrhosis with
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Molecular testing of cytology specimens: Issues in specimen adequacy and clinical utility Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-28 Ghulam Ghous, Komal Ijaz, Magda Esebua, Lester J. Layfield
Next generation sequencing (NGS) is standard of care for workup of many neoplasms including adenocarcinomas of the lung. Molecular testing of cytology samples is used for many types of neoplasms but the value of such testing for the selection of “first”- and “second-line” treatment protocols is incompletely understood.
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Fluorescent periodic acid Schiff-like staining combined with standard cytologic staining of the same cytologic specimen may facilitate cytopathologic diagnosis Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-24 Daisuke Hachisuka, Satsuki Nakano, Hiroshi Takase, Mio Sugiyama, Mariko Sugiura, Keiichiro Fujii, Ayako Masaki, Takayuki Murase, Hiroshi Inagaki
Periodic acid Schiff (PAS) staining which detects glycogen and mucosubstances is frequently used as an ancillary method for an accurate cytopathologic diagnosis. Unfortunately, cytologic slides for PAS stain are not routinely prepared. Aqueous 7-amino-4-methylcoumarin (AMC) is colorless and transparent under bright field illumination but exhibits strong fluorescence under ultraviolet (UV) light and
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Fine needle aspiration as a diagnostic modality for Warthin tumors identified as fluorodeoxyglucose positron emission tomography/computed tomography-positive Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-22 Adam Kowalewski, Hubert Tissot, Nina Jehanno, Elwira Bakuła Zalewska, Olivier Choussy, Maria Lesnik, Nathalie Badois, Guillaume Rougier, Jerzy Klijanienko
Limited evidence exists regarding the 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (FDG) avidity of Warthin tumors, the second most common benign parotid gland tumor. This study aims to clarify this aspect by analyzing patients who underwent FDG positron emission tomography/computed tomography (PET/CT) and quantifying tumor standardized uptake values (SUV). Medical records of 29 patients with fine needle
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Benchtop fine needle aspirations: An untapped source of cytologic educational material Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-22 Yubo Wu, Marcos Lepe
Fine needle aspirations (FNAs) are a valuable tool for the diagnosis of a wide variety of lesions. However, obtaining proficiency in performing FNAs and finding simulated scenarios where one can practice specimen adequacy and slide smearing can all be challenging. Benchtop FNAs of fresh surgical specimens offer a novel training opportunity that addresses these needs. In this study, we describe the
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Secretory carcinoma of parotid gland masquerading as acinic cell carcinoma on cytology: Case report and review of literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-11 G. Anju, Meenakshi Rao, Aasma Nalwa, Dharma Ram Poonia
Secretory carcinoma is a relatively recently discovered low-grade salivary gland carcinoma with morphological similarities to its breast counterpart. The histopathological features of this entity are well established; however, the cytomorphological features are not well evaluated, leading to diagnostic challenges and pitfalls. We report a case of secretory carcinoma (SC) of the parotid gland, which
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Cytomorphologic and immunocytochemical characterization of pediatric pleuropulmonary blastoma with a comprehensive review of the literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-14 Parikshaa Gupta, Sanjoli Chugh, Nalini Gupta, Kirti Gupta, Kushaljit Singh Sodhi, Nandita Kakkar, Radhika Srinivasan, Manish Rohilla, Reetu Kundu, Amita Trehan, Deepak Bansal, Nitin James Peters
Pleuropulmonary blastoma (PPB) is a rare, aggressive, primary intrathoracic malignancy typically seen in infancy and early childhood. Accurate distinction from congenital cystic lung lesions is crucial due to significant prognostic and therapeutic differences. Cytologic features have rarely been described. Establishing a cytodiagnosis is challenging owing to its rarity, lack of awareness, and multiple
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Utility of GATA-3 immunocytochemistry for the assessment of fine-needle aspiration in breast cancer patients with suspicious axillary lymph nodes at ultrasound Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-14 Zhihua Lan, Jing Zhang, Jianping Li, Rongfang He
Ultrasound-guided fine-needle aspiration cytology (FNAC) is a routine preoperative method for evaluating suspicious axillary lymph nodes (ALNs) in patients with breast cancer. However, a range of reasons such as morphological pitfalls, technical artifacts, and sampling errors restrict the sensitivity and accuracy of FNAC. This retrospective study investigated the diagnostic value of GATA-binding protein
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A retrospective analysis of molecular testing in cytologically indeterminate thyroid nodules with histologic correlation: Experience at a heterogenous multihospital system Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-10 Gloria H. Sura, Michael J. Thrall, John Rogers, Parsa Hodjat, Paul Christensen, Trisha D. Cubb, Helmi S. Khadra, Jessica S. Thomas, Elizabeth M. Jacobi
Thyroid malignancy is one of the most common types of cancer in developed nations. Currently, fine-needle aspiration cytology (FNAC) is the most practical screening test for thyroid nodules. However, cytologically indeterminate samples comprise approximately 15%–30% of cases. These include cases classified as atypia of undetermined significance (AUS), follicular neoplasm (FN), and suspicious for malignancy
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Morphological markers of chromosomal instability as predictors of malignancy in pleural effusion Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-09 Phiza Aggarwal, Uma Handa, Ranjeev Bhagat, Deepak Aggarwal
Malignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of morphological indicators of chromosomal instability (CI) like micronuclei (MN), chromatin bridging (CB), nuclear budding (NB), and multipolar mitosis (MM) on routine cytology
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Expression of EGFR, PD-L1, and the mismatch repair proteins before and following therapy in malignant serous effusions with metastatic high-grade serous tubo-ovarian carcinoma Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-08 Ilias P. Nikas, Soo-Young Park, Min Ji Song, Cheol Lee, Han Suk Ryu
To compare the immunochemical expression of EGFR, PD-L1, and the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6 between matched malignant effusions obtained before and following the administration of chemotherapy in patients with high-grade serous tubo-ovarian carcinoma (HGSC).
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Response to the letter regarding our study: Examining the impact of several factors including COVID-19 on thyroid fine-needle aspiration biopsy. Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-06 Muzaffer Serdar Deniz,Merve Dindar
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Correspondence to "Examining the impact of several factors including COVID-19 on thyroid fine-needle aspiration biopsy". Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-11-05 Hinpetch Daungsupawong,Viroj Wiwanitkit
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Cytological findings of phosphaturic mesenchymal tumor: Report of a case with summary of prior published cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-28 Oindrila Das, Md Mohin, Soumya Dey, Anish Kar, Pankaj Singhania, Souvik Adhikari, Subhankar Chowdhury, Uttara Chatterjee
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm causing tumor-induced osteomalacia (TIO) and is characterized by secretion of FGF23, renal phosphate wasting and hypophosphataemia. It can be completely cured by resection and therefore its diagnosis is of utmost importance. Although the histology is well described, there is sparse literature on cytology of PMT and only three cases have been described
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A case of extranodal NK/T-cell lymphoma, nasal type, diagnosed by scraping cytology of the maxillary gingiva Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-27 Hiroe Niwa, Kazumi Mukai, Iyo Kimura, Johji Imura
Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is often seen in the head and neck region, but there have been rare instances of this disease with initial presentation as a lesion in the oral mucosa. The patient, a woman in her seventh decade of life, presented with an ulcer in the maxillary gingiva, and scraping cytology and biopsy were performed. Cytological specimens showed solitary or small
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High-grade medullary thyroid carcinoma with papillary-like nuclear features: A report of five cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-16 Naoki Yamao, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Tomo Ishisaka, Akira Miyauchi, Takashi Akamizu
Medullary thyroid carcinoma (MTC) with papillary-like nuclear features has not been previously described. Here, we aimed to describe the unique features of MTC and examine their prognostic value as markers of high-grade MTC.
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Fine-needle aspiration of a pancreas with squamoid cyst of pancreatic duct and pancreatic duct stones: A case report of a rare pancreatic lesion and an unusual concurrent finding of stone-related crystals Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-14 Yin Huei Pang, Li Yin Ooi
Squamoid cyst of pancreatic duct is a rare benign pancreatic lesion that is rarely encountered in fine-needle aspiration (FNA) and surgical resection specimens. Pancreatic stones can be seen in chronic pancreatitis, but stone-related crystals have previously not been described in pancreatic cytology. Presented here is a case report of a squamoid cyst of pancreatic duct with concurrent pancreatic duct
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Granulomatous mastitis: A diagnostic challenge—3 year single institutional experience Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-13 Adil Aziz Khan, Sana Ahuja, Sufian Zaheer, Charanjeet Ahluwalia, Mukul Singh, Sachin Kolte, Sunil Ranga
Granulomatous mastitis (GM) is often clinico-radiologically misdiagnosed as breast malignancy. Tuberculosis, foreign body reactions, fungal and parastic infections, and autoimmune diseases can cause GM. The present study aimed to assess the spectrum of GM on fine-needle aspiration biopsy (FNAB) smears along with its histopathological and clinico-radiological findings.
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Claudin-4 immunocytochemistry is specific and sensitive for the diagnosis of malignant carcinomatous effusions: Results from a pilot study Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-10-13 Vanlal Hruaii, Balamurugan Thirunavukkarasu, Vindhya Prabha, Sandeep Mathur, Venkateswaran K. Iyer, Aruna Nambirajan, Deepali Jain
Claudin-4, a tight junction associated protein expressed in epithelial cells, is purported as a highly specific and sensitive marker for epithelial malignancies. Our aim was to assess the sensitivity, specificity and real-time utility of claudin-4 immunocytochemistry (ICC) in the diagnostic work-up of suspected malignant effusions.