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Chinese expert consensus on the management of patients with hematologic malignancies infected with SARS-CoV-2 J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-12-28 Jun Wang, Liang Shao, Jing Liang, Qingming Wu, Baoli Zhu, Qiwen Deng, Zelin Liu, Liqiong Liu, Danyu Wang, Zhijian Yu, Xiaohua Tan, Fuxiang Wang, Jingye Meng, Xiaojun Xu, Zhongjun Xia, Zhiming Li, Hua Wang, Liang Wang, Wei Wu, Qi Xie, Xiaoxing Huang, Zhiqiang Sun, Yu Zhang, Hao Zhou, Hui Zhou, Wenyan Yang, Hua Ren, Zhe Liu, Mingqiang Qiao, Feifei Tang, Xiaofei Qi, Huijing Wu, Lijuan Deng, Li Gao, Hongyan
In December 2022, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became dominant in China due to its high infectivity and lower mortality rate. The risk of critical illness and mortality among patients with hematologic malignancies who contracted SARS-CoV-2 was particularly high. The aim of this study was to draft a consensus to facilitate effective treatments for
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Aberrantly expressed HIF-1α enhances HCC stem cell-like traits via Wnt/β-catenin signaling activation after insufficient radiofrequency ablation J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-12-28 Ning Zhang, Ruoxue Chen, Xin Cao, Lu Wang
Background: Radiofrequency ablation has become a favorable treatment modality for small hepatocellular carcinoma (HCC) recently; however, insufficient radiofrequency ablation (RFA) was shown to lead to enhanced invasiveness and metastasis of HCC in our previous study, while the underlying molecular mechanism has not been understood. Materials and Methods: In order to explore the influence of the
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Local treatment of liver metastasis in a patient with advanced malignant melanoma: A case report J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-12-28 Hongxi Hong, Lujun Shen, Hongtong Tan, Ying Wu, Ying Liu, Weijun Fan
Melanoma is a fatal malignant tumor with a high rate of metastasis. Liver metastasis of melanoma is always associated with insensitivity to immunotherapy and a poor prognosis. However, the combination of cryoablation, which is believed to stimulate the antitumor immune response in the body, with immunotherapy can improve the therapeutic response to this condition. Herein, we present the case of a 79-year-old
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Sexual function status after adjuvant radiation including vaginal cuff brachytherapy in survivors of cancer cervix J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-12-29 Isha Puri, Rahul Sharma, Deepika Dewan, Shabab Angurana, Deepak Abrol, Dinesh Kumar
Context: Adjuvant radiation therapy plays an important role in the management of high-risk cervical cancer after radical hysterectomy or inadvertent hysterectomy. The prime concern with the use of dual modality is steep decline in sexual well-being in cervical cancer survivors. Intravaginal brachytherapy (IVBT) delivered by vaginal cylinder or ovoids is essential for local control but at the cost
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Immunotherapy for early-stage non-small cell lung cancer: A system review J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-08-28 Jingyi Gao, Chao Zhang, Zhigang Wei, Xin Ye
With the addition of immunotherapy, lung cancer, one of the most common cancers with high mortality rates, has broadened the treatment landscape. Immune checkpoint inhibitors have demonstrated significant efficacy in the treatment of non-small cell lung cancer (NSCLC) and are now used as the first-line therapy for metastatic disease, consolidation therapy after radiotherapy for unresectable locally
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Clinical features and outcomes of infantile soft-tissue sarcoma: A multicenter retrospective study in Beijing J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-08-28 Shuai Zhu, Na Xu, Tian Zhi, Yangxu Gao, Dixiao Zhong, Weiling Zhang, Mei Jin, Qing Sun, Yao Xie, Xiaolun Zhang, Long Li, Shengcai Wang, Huanmin Wang, Rong Liu, Weihong Zhao, Dongsheng Huang, Xin Ni, Xiaoli Ma
Background: Soft-tissue sarcomas during infancy are rare and understudied. With no data on this specific condition, we performed a retrospective study of infant-onset sarcomas based on a multi-institutional cohort in Beijing, China, collected over the past decade. We reviewed infantile soft-tissue sarcomas’ clinical characteristics, treatments, and outcomes. Materials and Methods: The patients with
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Significant response to transarterial chemoembolization combined with PD-1 inhibitor and apatinib for advanced intrahepatic cholangiocarcinoma: A case report and literature review J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-08-28 Haitao Zhang†, Cuiping Han†, Xiaohuan Zheng, Wenhua Zhao, Yuanshui Liu, Xin Ye
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy rising from the biliary tree with poor prognosis. We report the feasibility and efficacy of transarterial chemoembolization (TACE) combined with PD-1 inhibitor and apatinib for the treatment of a patient with unresectable ICC. A 70-year-old female presented with intermittent right upper abdominal distension, abdominal pain, and
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Cisplatin-based combination therapy for cancer J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-28 Minerva, Amrita Bhat, Sonali Verma, Gresh Chander, Rajeshwer Singh Jamwal, Bhawani Sharma, Audesh Bhat, Taruna Katyal, Rakesh Kumar, Ruchi Shah
Cisplatin, that is, cis-diamminedichloroplatinum is a coordinate compound that is mainly preferred as prior treatment against several solid tumors and malignancies like ovaries, head and neck, testicular, and lung cancers because of its anticancer activity. Cisplatin binds at the N7 position of purine and forms adducts, leading to altered activity of DNA that triggers apoptosis. DNA damage is followed
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Potential implications of mobile applications in oral cancer J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-27 Deepti Sharma, Shruti Gupta, George Koshy, Vishal Kumar Sharma, Anita Hooda
The modern era has observed vast technological advancements with a definite impact on the health sector. There has been an upsurge in mobile applications (mApps) used for varied purposes. Many mApps are available that target different arenas in dentistry including a range of oral health issues, the most important being oral cancer. These mApps with specific algorithms have been used for risk assessment
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A novel EML4–NTRK3 fusion in lung adenocarcinoma with dramatic response to entrectinib J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-26 Ullas Batra, Shrinidhi Nathany, Mansi Sharma, Parveen Jain, Anurag Mehta, Abhishek Bansal
In-frame fusions in NTRK genes, with intact kinase domain, have been reported to occur at higher frequencies in rare tumors like infantile fibrosarcoma, congenital mesoblastic nephroma, and secretory carcinoma, whereas they occur at very low frequencies in common malignancies like NSCLC and colon cancers (0.1%–1%). Despite the rare occurrence, these alterations have gained importance owing to approval
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Primary signet ring cell carcinoma of prostate: A rare case report and review of literature J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-21 Monika Gupta, Archana Budhwar, Nikita Prasad, Sujata Kumari SP Prasad, Sunita Singh
Primary signet ring cell carcinoma (PSRCC) of the prostate is an extremely rare variant of prostatic adenocarcinoma. A PubMed search of the English language literature from January 2000 to June 2020 using the keywords “signet ring cell carcinoma” and “prostate,” identified 20 cases of PSRCC of the prostate. On the basis of the combined data from this study and the literature review, 21 such patients
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The adherence to the American Association for the Study of Liver Diseases 2018 guidelines in the management of hepatocellular carcinoma and its impact on survival J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-21 Ashish Manne, Madhuri Mulekar, Daisy Escobar, Pranitha Prodduturvar, Yazan Fahmawi, Phillip Henderson, Osama Abdul-Rahim, Zeiad Hussain, Spencer Liles, Annabelle Fonseca, John Harrison Howard, Wadad Mneimneh, Robert Gilbert, Omar Alkharabsheh, Sachin Pai, Zachary B White, Cindy Nelson, Moh’d Khushman
Introduction: In two Korean and Italian studies, the adherence rate (AR) to ASSLD 2005 guidelines in the management of hepatocellular carcinoma (HCC) was 60%. In a US study, the AR to American Association for the Study of Liver Disease (AASLD) 2005 guidelines was 73.3%, 26.8%, 25.3%, and 58.8% for patients with Barcelona Clinic Liver Cancer (BCLC) Stage A, B, C, and D, respectively, and nonadherence
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A plan comparison study between rapid arc and conventional intensity-modulated radiation treatment plans in nasopharyngeal carcinoma patients J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-21 Yaman Patidar, H. S. Kumar, Neeti Sharma, Athiyaman Mayilvaganan
Introduction: Head and neck cancers are one of the common malignancies in Indian population. It’s entity, nasopharyngeal carcinoma is among the aggressive malignancies with its location and spread near very critical structures. Thus requires a highly conformal radiotherapy delivery techniques. Purpose: The aim of the study is to dosimetrically evaluate and to compare Intensity modulated radiation
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Solitary fibrous tumor of the seminal vesicle J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-04-20 Shikha Goyal, Renu Madan, Urmi Mukherjee, Rajender Kumar
Solitary fibrous tumors (SFTs) are mesenchymal neoplasms with variable clinical behavior depending on age, tumor site, and size, and pathologic factors such as mitoses and necrosis. Imaging features on computed tomography (CT) or magnetic resonance imaging (MRI) are not specific, and the diagnosis relies on histopathology with immunohistochemistry. SFTs arising from seminal vesicles is rare and reported
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SPACES: Our team’s experience in lung tumor microwave ablation J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-03-01 Zhigang Wei, Xia Yang, Jing Wu, Peng Zhang, Guanghui Huang, Yang Ni, Guoliang Xue, Xin Ye
The standard treatment of stage I nonsmall cell lung cancer is lobectomy with systematic mediastinal lymph node evaluation. Unfortunately, up to 25% of patients with stage I nonsmall cell lung cancer are not candidates for surgery due to severe medical comorbidities (poor cardiopulmonary function). Image-guided thermal ablation is an alternative for those patients, includes radiofrequency ablation
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Discussion on the necessity of bilateral inguinal lymphatic area irradiation for cervical cancer with invasion of the lower one-third of the vagina J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-03-01 Haiyan Cheng, Lina Wang, Le Wang, Qi Li
Context: According to the National Comprehensive Cancer Network guidelines for cervical cancer, patients with cervical cancer invading the lower one-third of the vagina require bilateral inguinal lymphatic area preventive irradiation. However, it is not clear whether they need preventive inguinal area irradiation. Aims: The aim of this study is to evaluate the necessity of bilateral inguinal lymphatic
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A combination of anti-PD-1 therapy and apatinib successfully treated a patient with EGFR mutation-negative advanced lung adenocarcinoma: A case report J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-03-01 Jian Wang, Shancheng Li, Lei Zhang, Xikun Zhang
Here, we report the case of a patient with advanced lung adenocarcinoma with negative driver genes, who benefited from treatment with anti-programmed cell death-1 (anti-PD-1) therapy combined with a low dose of apatinib. From February 2020, the patient was treated with camrelizumab combined with pemetrexed disodium. The treatment regimen was adjusted to camrelizumab combined with a low dose of apatinib
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Diagnostic accuracy of Vibrational spectroscopy in the diagnosis of oral potentially malignant and malignant disorders: A systematic review and meta-analysis J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-01-01 Priyanshu Kumar Shrivastava, Ansul Kumar, Yogendra Aggarwal, Amit Kumar, Anushka Agrawal, Arpita Rai
Oral malignant and potentially malignant conditions affect several people worldwide each year. The early diagnoses of these conditions play an important role in prevention and recovery. Vibrational spectroscopy techniques such as Raman spectroscopy (RS) and Fourier-transform infrared (FTIR) spectroscopy are used in the early, non-invasive, label-free diagnosis of malignant and pre-malignant conditions
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Target volume coverage in clinically designed radiotherapy plan of post-mastectomy adjuvant radiotherapy of breast cancer patients in comparison with radiation therapy oncology group-based contoured plan: A dosimetric study J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-01-01 Mohammad Azam, Animesh Agrawal, Kamal Sahni, Madhup Rastogi, Arun Kumar Rathi, S. Farzana
Objective: Conventional field radiotherapy based on anatomical landmarks has been the traditional treatment for breast cancer. Having proven efficacy, it is still the current standard of treatment. The Radiation Therapy Oncology Group (RTOG) has published guidelines for contouring target volumes in postmastectomy patients. The impact of this guideline in the current clinical practice is less known;
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Case series of head-and-neck adenosquamous carcinoma: Role of histogenetic model in immunotherapy as a future perspective for nonconventional squamous cell carcinoma J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-01-01 Shefali Yadav, Nikita Gulati, Anshi Jain, Devi Charan Shetty
Adenosquamous carcinoma (ASC) is not only a rare variant of squamous cell carcinoma (SCC) but it is also an aggressive and highly infiltrating neoplasm with distinct histomorphology. Histogenetic concept in the pathogenesis of the tumor would eradicate controversies regarding the resemblance of ASC with mucoepidermoid carcinoma and adenoid SCC. Hence, we intend to present a case series of four cases
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Consolidative radiation in partial responders/unresectable/recurrent disease after first-line/salvage chemotherapy in poor-risk nonseminomatous germ cell tumor prolongs survival: A new paradigm? J. Cancer Res. Ther. (IF 1.3) Pub Date : 2023-01-01 Sandeep Tiwari, Sushma Agrawal
The role of radiotherapy (RT) in partial radiographic response (PR)/unresectable has not been evaluated earlier in nonseminomatous germ cell tumor (NSGCT). Can the PR/unresectable be treated with consolidation RT instead of surgery? This approach will allow avoidance of surgical morbidity and be an additional tool for treatment. We report a series of five cases with poor prognosis NSGCT, who were treated
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Chinese expert consensus on intestinal microecology and management of digestive tract complications related to tumor treatment (version 2022) J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-12-01 Jun Wang, Jing Liang, Mingxin He, Qi Xie, Qingming Wu, Guanxin Shen, Baoli Zhu, Jun Yu, Li Yu, Xiaohua Tan, Lanlan Wei, Jun Ren, Youyong Lv, Lijuan Deng, Qian Yin, Hao Zhou, Wei Wu, Min Zhang, Wenyan Yang, Mingqiang Qiao, Rong Shu, Zhongjun Xia, Zhiming Li, Ziming Huang, Weiguo Hu, Liang Wang, Zhi Liu, Guoliang Pi, Hua Ren, Yong Ji, Zhe Liu, Xiaofei Qi, Peng Chen, Liang Shao, Feng Chen, Xiaojun Xu
The human gut microbiota represents a complex ecosystem that is composed of bacteria, fungi, viruses, and archaea. It affects many physiological functions including metabolism, inflammation, and the immune response. The gut microbiota also plays a role in preventing infection. Chemotherapy disrupts an organism's microbiome, increasing the risk of microbial invasive infection; therefore, restoring the
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Microwave ablation of the lung: Comparison of 19G with 14G and 16G microwave antennas in: ex vivo: porcine lung J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-12-01 Hongchao Cai, Hui Tian, Zhigang Wei, Xin Ye
Background: Percutaneous image-guided thermal ablation has an increasing role in the treatment of primary and metastatic lung tumors. Although microwave ablation (MWA) has emerged advantageous as a new ablation technology, more research is needed to improve it. This study aims to investigate the ablation zone of three microwave antennas in ex vivo porcine lung. Materials and Methods: In the ex vivo
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Inflammatory myofibroblastic tumor from the greater omentum in children: A rare case report J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-12-01 Honghao Song, Huiyu Zhang, Yongfei Zhang, Xiaoqing Wang, Wei Liu
Inflammatory myofibroblastic tumor (IMT) prevalence is less than one in a million. Anaplastic lymphoma kinase (ALK)-positive IMT in the greater omentum and with a diameter greater than 8 cm is extremely rare. Here, we present a case and provide a brief literature review. A 4-year-old female was referred to our hospital with a 1-month history of intermittent fever. Computed tomography revealed a 6.4
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Solitary osteochondroma of the rib: An unusual chest wall tumor in the pediatric age group J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-09-10 Charu Tiwari, Nitinkumar Borkar, Nighat Hussain, Naveen Khubchandani
Pediatric chest wall tumors are unusual and can arise from bone structures or from adjacent soft tissues. Osteochondroma is a benign cartilaginous tumor arising from the metaphysis of bone; however, it is more common in extremity rather than in membranous bone. Although benign, osteochondroma of the rib may lead to fatal complications such as pneumothorax, hemothorax, fractures, and pleural or pericardial
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DNA base excision repair gene variants and susceptibility to ovarian cancer. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Sora Yasri,Viroj Wiwanitkit
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New Wuhan coronavirus: Any carcinogenicity property? J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Beuy Joob,Viroj Wiwanitkit
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When to use dual staining in cervical cancer screening? J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Wiebren A A Tjalma
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"Likely to be missed if unsuspected": FIP1L1-PDGFRA positive myeloid neoplasm in a patient with nodal T-lineage lymphoblastic lymphoma. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Praveen Sharma,Niranjan Shiwaji Khaire,Sreejesh Sreedharanunni,Pankaj Malhotra,Neelam Varma
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Challenging case of a re-irradiation in a dorsal spine primitive neuroectodermal tumor: Role of modern image-guided pencil beam proton therapy. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Utpal Gaikwad,Satadru Biswas,Dayananda Shamurailatpam,Kartikeshwar Patro,Mayur Sawant,Rakesh Jalali
Extradural primary primitive neuroectodermal tumor (PNET) is a rare aggressive disease mostly occurring in young adults. We present a locally recurrent case of dorsal PNET in the fifth decade of life after a prolonged disease-free interval of 10 years. The patient received radiation therapy in fairly large fields twice in his lifetime and was planned for third-time radiation to a few overlapping paraspinal
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Gastric immature teratoma arising from the lesser curvature of the stomach: A rare case report. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Madhu Kumar,Akanksha Singh,Damini Singh
Immature gastric teratoma is an uncommon germ cell tumor of the stomach. A 6-month-old male child was born through full-term vaginal delivery. After 1 month presented with a history of abdominal distension and palpable mass along with a history of Malena for the past 10 days. Computed tomography scan showed the presence of a large well-defined multilobulated solid cystic lesion with multiple calcifications
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Radiation-induced synchronous mandibular osteosarcoma and papillary thyroid carcinoma: A disguised conundrum. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Neha Kumari,Kinjal Shankar Majumdar,Shahab Ali Usmani,Satya Prakash Agarwal
With substantial improvement in survival in cancer patients, the risk of radiation-induced malignancy in previously irradiated areas is increasingly possible. Both radiation-induced sarcomas and papillary thyroid carcinomas (PTCs) are well documented in literature. However, radiation-induced synchronous malignancies are rare, are often misdiagnosed, and presents with diagnostic and therapeutic challenges
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A 47-year-old man with rare serous cyst adenocarcinoma of the testis. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Zahra Pourvali-Souraki,Ehsan Zaboli,Ghasem Janbabaei,Reza Alizadeh-Navaei
Although papillary serous cyst adenocarcinoma of the ovary is a common tumor, the incidence of ovarian-type papillary serous cyst adenocarcinoma in the testis is rare. Based on medical documents, there are only about 50 cases reported about testicular and paratesticular serous tumors.[1],[2],[3] Herein, we report a case of low-grade serous cyst adenocarcinoma of the testis that did unilateral orchiectomy
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Acute myeloid leukemia presenting in a human immunodeficiency virus-positive patient. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Shano Naseem,Pooja Murgai,Neelam Varma,Subhash Varma
We report a case of AML in a 29-year-old HIV-positive female on anti-retroviral therapy. She presented with bicytopenia, fever and easy fatiquability. Bone marrow examination revealed 77% blasts, which on flow cytometric immunophenotyping showed positivity for myeloid lineage markers and were negative for monocytic and lymphoid lineage markers. Although rare, AML is seen in HIV patients, therefore
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Paroxysmal nocturnal hemoglobinuria clone in a patient with acute promyelocytic leukemia. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Balraj Singh,Nazia Khan,Parminder Kaur,Michael Maroules
Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), which presents with a distinct coagulopathy. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia which is clonal in nature due to somatic mutation. PNH may evolve to aplastic anemia, and more rarely, to a myelodysplastic syndrome or to AML. The literature review showed that AML is derived from
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Urachal adenocarcinoma: A case report and review of the literature. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Zeynep Gural,Serap Yücel,Sedenay Oskeroğlu,Fulya Ağaoğlu
The urachus is a canal between the allantois and the early fetal bladder. Urachal carcinoma is a rare and aggressive type of bladder cancer. This cancer usually presents at an advanced stage. We report a 70-year-old patient with malignant transformation of urachal cyst several years later. The patient was treated with partial cystectomy and adjuvant radiotherapy. A review of the published literature
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Giant cell tumor of hyoid bone: Diagnostic dilemma with a novel management. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Ameya Bihani,Shivakumar Thiagarajan,Devendra Chaukar,Anil K D'Cruz
Giant cell tumor of bone (GCTB) is locally aggressive tumor occurring in the epiphysis of long bones. GCTBs are uncommon tumors in the head-and-neck region and rarely involve hyoid bone. We report a case of GCTB of hyoid bone. The patient presented with swelling in left submandibular region. The tumor was surgically excised after initial denosumab therapy. Despite adequate resection and rehabilitation
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Early detection of isolated pleural metastasis from carcinoma pyriform fossa: Can it be steered away from doom? J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Bhanu Vashistha,Palak Garg,Preety Negi,Pamela Alice Kingsley
Isolated pleural metastasis from carcinoma of the pyriform fossa is a rare phenomenon. Literature search revealed pleural metastasis from head-and-neck cancer is in itself rare and carries a grave prognosis. Isolated pleural metastasis with local control in the primary and regional site with no other documented distant metastatic disease is again rarely encountered. We report this case as detection
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Post hysterectomy mesonephric carcinoma: A case report and literature review. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Sanjay Kumar,Sucheta,Bharti Saklani,Archana,Raman Kapil,Rajeev Sen
Mesonephric carcinoma is a rare type of carcinoma seen in the female genital tract. It arises from the mesonephric remnants situated in the broad ligament, lateral wall of the cervix, vagina, and uterine corpus. Very few cases of mesonephric carcinoma have been reported so far in the literature. The sites mentioned in various literatures include the cervix, vagina, or uterus, but we could not find
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Isolated humeral metastasis in cervical cancer: A case report and review of the literature. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Alessandro Gioe,Damiano Arciuolo,Vittoria Carbone,Gianfranco Zannoni,Maria Antonietta Gambacorta,Giulio Maccauro,Giovanni Scambia,Giacomo Corrado
There are a few reported cases of isolated localized metastasis to bone arising from cancer of uterine cervix in the literature. This is a case of uterine cervix cancer with isolated metastasis to the humerus. A 57-year-old female with a diagnosis of FIGO Stage IIB invasive squamous cell carcinoma of uterine cervix underwent neoadjuvant chemoradiation therapy (CRT) and radical surgery with complete
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Primary intramedullary spinal gliosarcoma: An unusual presentation. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Snigdha Hazra,Sayan Kundu,Bodhisattwa Dutta,Asit Ranjan Deb
Gliosarcoma is a biphasic central nervous system malignancy composed of glial and mesenchymal components. It is recognized as a rare variant of glioblastoma with unique histology, immunostaining properties, and natural history. Although usually described to primarily involve the brain, a search of the published literature revealed four reported cases of gliosarcoma arising in the spinal cord. This
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Aggressive oral carcinoma cuniculatum: A rare entity. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 J V Abilasha,Prasanth Thankappan,T Isaac Joseph,D Angelin
Oral carcinoma cuniculatum (OCC) is a rare and distinct clinicopathological variant of oral squamous cell carcinoma (OSCC). The term cuniculatum was derived from a Latin word "cuniculus" meaning burrow, because of the "rabbit burrow" appearance. As it invades the underlying tissue, it forms crypts filled with keratin that are essential in distinguishing this neoplasm from other variants of squamous
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Highly aggressive gastric adenocarcinoma with multiple skin nodule and supraclavicular node in a 19-year-old patient: A rare presentation in such young age. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Deepak Raj Sonkar,Arun Kumar Rathi,Savita Arora,Mohammad Azam,Kumar Prabhat,Kishore Singh
Although gastric adenocarcinoma is common in middle- and old-aged population, it is rare in young people. Development of cutaneous metastasis during presentation is even rarer in any age group. We report the case of a 19-year young man with gastric adenocarcinoma who had multiple skin nodules over the trunk during presentation. Fine-needle aspiration cytology of the nodule revealed it to be metastasis
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Cryoablation treatment of oral and maxillofacial tumors: Five case reports. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Xiao Li,Ya-Wen Wang,En-Bo Wang,Yuan-Shui Liu
Oral and maxillofacial anatomy and function are important and complex. They are involved in facial expressions, chewing, language, breathing, and other functions. It is therefore important to choose the optimal treatment plan for oral and maxillofacial tumors. For patients with who cannot tolerate surgery or who refuse surgery or radiotherapy can be treated with cryoablation. Cryoablation can maintain
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Erythroderma: An unusual manifestation of imatinib - A rare case report. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Pritam Kataria,Apurva Patel,Pradip Kendre,Nahush Tahiliani,Tushar Mule,Murtaza Bohra
Imatinib is a tyrosine kinase inhibitor that selectively inhibits several protein tyrosine kinases which is central to the pathogenesis of human cancer. It forms the first-line treatment for chronic myeloid leukemia (CML) and gastrointestinal stromal tumors. Usually, the drug is well-tolerated with relatively few side effects. Adverse effects most commonly associated with imatinib include mild-to-moderate
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Anorectal malignant amelanotic melanoma: Report of a rare aggressive primary tumor. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Musharraf Husain,Tajamul Rashid,Mir Mujtaba Ahmad,Mohammad Jaseem Hassan
Malignant melanoma of the anorectal region is a very rare aggressive malignant neoplasm and it constitutes 1% of all malignant lesions of this area. About 70% of these lesions are pigmented, whereas 30% are amelanotic. Demonstration of immune markers of melanoma by immunohistochemistry (IHC) is required for confirming the diagnosis of amelanotic malignant melanoma. Here, we report a case of anorectal
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How prepared the radiotherapy centers are to deal with COVID-19 pandemic? A nationwide survey from 46 cancer centers across India. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Sandip Kumar Barik,Binod Kumar Behera,Saroj Kumar Das Majumdar,Dillip Kumar Parida
Managing of radiotherapy department in many cancer centers in India has become very challenging during the COVID-19 pandemic. A radiotherapy center has to deal with multiple problems such as long treatment duration of each patient, high caseload on each radiotherapy machine, a limited number of qualified technical staff available, and equipment maintenance. For the department's smooth running, both
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Evaluation of cytotoxic effects of fungal origin nanosilver particles on oral cancer cell lines: An in vitro study. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Kiran R Halkai,Rahul Halkai,Supriya Patil,Jameela Alawadi,Wafa Saeed Alawadhi,Narender Reddy Marukala,Nassreen Hassan Mohammad Albar,Shreeshail Indi
Background Oral cancer is often associated with poor prognosis and it is found that conventional treatment options cause severe side effects, adjacent tissue disfigurement, and loss of function. Recently, silver nanoparticles (AgNPs) paved their path for cancer treatment. Aim This study aimed to investigate cytotoxic effects of fungal procured AgNPs on oral squamous cell carcinoma (SCC-9) cell line
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Detection of differential expression of miRNAs in computerized tomography-guided lung biopsy. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Anjana Singh,Ravi Kant,Soumyadeep Nandi,Nuzhat Husain,Manisha Naithani,Anissa Atif Mirza,Tajindra Singh Saluja,Kamini Srivastava,Ved Prakash,Satyendra Kumar Singh
Aims Nonsmall-cell lung carcinoma comprises 85% of lung malignancies and is usually associated with a poor prognosis due to diagnosis at advanced stages. Molecular diagnosis of computerized tomography (CT)-guided biopsy has the potential to identify subtypes of lung carcinoma like adenocarcinoma (AC) and squamous cell carcinoma (SCC) along with its molecular stratification. This approach will help
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Can a signature molecular-profile define disparate survival in BRAF-positive Gliosarcoma and identify novel targets for therapeutic intervention? J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Puneet Gandhi,Richa Khare,Nitin Garg,Jharna Mishra
Purpose Gliosarcoma (GS) has a low incidence but is aggressively invasive, with poor-survival. Even though GS is recognized as a different subgroup from glioblastoma (GB), there is no molecular panel available to define its clinical outcome. The objective was to identify the molecular imprint of GS in terms of expression of human telomerase reverse transcriptase (hTERT), high mobility group A1 (HMGA-1)
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Predictive significance of inflammatory indexes in metastatic nonsmall cell lung cancer patients treated with platinum-doublet chemotherapy. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Mesut Yilmaz,Ahmet Baran,Merve Korkmaz Yilmaz
Introduction Lung cancer is the leading cause of cancer-related deaths, worldwide. Despite immune checkpoint inhibitors and targeted therapy have revolutionized the treatment of metastatic nonsmall cell lung cancer (NSCLC), a significant proportion of patients are still treated with platinum-based chemotherapy. It is widely noticed that systemic inflammation plays an important role in the development
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Knowledge, attitude, and practice of radiation oncologists during COVID-19 pandemic. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Aarathi Ardha,Nanuvala Prathyusha,Bijjal Atreya,D Asha,Sanjeeva Kumari
Background Cancer care hospitals are taking measures to reduce the spread of COVID-19. Doctors and health-care workers might be suffering from burnout. Measures taken to reduce overcrowding in hospitals might be making access to essential cancer care difficult. The study aims to understand changes in practice, levels of burnout, and other psychological aspects in radiation oncologists working in a
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Spectrum of pediatric kidney tumours with special references to WT1 immunostain at a tertiary care hospital. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Chhanda Das,Madhumita Mukhopadhyay,Namrata Maity,Tamanna Parvin,Biswanath Mukhopadhyay,Brati Mukhopadhyay
Context or Background Pediatric renal tumours are the second most common solid tumours in children. The most common in this group is Wilms tumour with mesoblastic nephroma being the 2nd most common tumour in children, younger than 3 months. Aims and Objectives The present study was conducted to study the epidemiological occurrence of pediatric renal tumours at a tertiary care hospital and to study
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Monte Carlo simulation for assessing absorbed dose effects of low-dose β-radiation (90Sr/90Y) on cytotoxicity and apoptotic death in K562 cells. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Zeynab Alizadeh,Rasoul Khodabakhsh,Mehdi Mohammadzadeh,Yaghub Pazhang,Seyed Mostafa Mohammadi
Objective Most studies suggest that dose-specific radiation regimens are essential for optimal induction of cancer cell response. This study focused on determining β-radiation-absorbed dose (rad) effects on the cell viability, cytotoxicity, hypersensitivity, and cell death of K562 cells using experimental methods and Monte Carlo simulation (MCS). Materials and Methods The K562 cells were cultured and
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Evaluation of field-in-field, three-field, and four-field techniques for treatment planning of radiotherapy of pancreatic cancer. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Mohamad Pursamimi,Mahdi Ghorbani,Wrya Parwaie,Ahmad Shakeri,Ali Soleimani Meigooni
Background Pancreatic adenocarcinoma is a lethal condition with poor outcomes by various treatment modalities and an increasing incidence. Aim The aim of this study is to evaluate the advantages of field-in-field (FIF) versus three-field and four-field radiation treatment planning techniques in three-dimensional treatment of patients with pancreatic cancer. Materials and Methods: The evaluations of
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Fine needle aspiration cytology of primary thyroid non-hodgkins lymphoma: Experience from a tertiary care center of North India. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Meeta Singh,Gunjan Nain,Shyama Jain,Sarika Singh,Vikas Malhotra
Presentation Twelve cases of Primary Thyroid Non-Hodgkin's Lymphoma (PT-NHL) were retrieved from the records suspected or diagnosed as NHL on fine needle aspiration cytology (FNAC) over a period of nine years from 2010-2018. During this period 5236 patients underwent thyroid FNAC;of these 685 cases were diagnosed under Bethesda Caregory V and VI. Thyroid NHL constituted 0.23 % of all thyroid FNA (12/5236
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The effect of medicarpin on PTEN/AKT signal pathway in head and neck squamous cell carcinoma. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Aysel Kalayci Yiğin,Huseyin Donmez,Mustafa Hitit,Sena Seven,Nadire Eser,Ercan Kurar,Mehmet Seven
Background/Aim We aimed to investigate the in vitro modulating effects of medicarpin on the PI3K/AKT signal pathway gene expressions in head and neck squamous cell carcinoma (HNSCC). Materials and Methods The effect of medicarpin on PTEN and other associated genes in the PTEN/AKT signal pathway was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, real-time quantitative
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Tumor control after palliative hypofractionated, "Quad-shot," external beam radiotherapy followed by brachytherapy: An effective approach in medically compromised and/or elderly patients with cervix cancer. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Chairat Lowanich Kiattikul,Kailash Narayan,David Bernshaw,Sylvia Van Dyk,Angelo Tzovaras,Ming Yin Lin
Context Cervix cancer is still a leading cause of death in developing countries. Concurrent chemoradiation (CCRT) over 5 weeks followed by brachytherapy is standard of care in locoregionally advanced cervix cancer. Such prolonged treatment may not be tolerated in medically compromised patients. High-dose interrupted hypofractionated Quad-Shot (QS) radiotherapy with brachytherapy treatment was well
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Modified neoadjuvant clinicopathological risk stratification as a prognostic score in early and locally advanced triple-negative breast cancer. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Biswajit Dubashi,Kirankumar Matta,Smita Kayal,Divya Bala Thumathy,Yadav Nisha,Kadambari Dharanipragada,Karunanithi Gunaseelan,Pampa Ch Toi,Prasanth Ganesan
Background Triple-negative subtype is an aggressive breast cancer with inferior survival. Pathological complete remission (pCR) is a good surrogate endpoint for survival among patients receiving neoadjuvant chemotherapy (NACT). We attempted to validate the clinical pathological score (CPS) with a modified risk grouping among Triple-negative breast cancer (TNBC) patients receiving NACT at our center
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Preparation and preclinical characterization of 111In-DTPA-Anti-MUC1 as a radioimmunoconjugate for diagnosis of breast cancer by single-photon emission computed tomography. J. Cancer Res. Ther. (IF 1.3) Pub Date : 2022-04-07 Behrouz Alirezapour,Mahmood Dehghani Ashkezari,Mehdi Memari Fini,Mohammad Javad Rasaee,Javad Mohammadnejad,Malihe Paknejad,Ehsan Maadi,Hassan Yousefnia,Samaneh Zolghadri
Context Targeting MUC1 antigens which are overexpressed in 80% of breast cancers can be widely used in the field of radioimmunoscintigraphy (RIS) of breast cancer. Aims The aim of this study was to develop a new diagnostic labeled compound for breast cancer RIS. Settings and Design In this study, an efficient indirect labeling method of PR81 with Indium-111 was developed and preliminary preclinical