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The cell cycle revisited: DNA replication past S phase preserves genome integrity Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-02-10 Spyridoula Bournaka, Nibal Badra-Fajardo, Marina Arbi, Stavros Taraviras, Zoi Lygerou
Accurate and complete DNA duplication is critical for maintaining genome integrity. Multiple mechanisms regulate when and where DNA replication takes place, to ensure that the entire genome is duplicated once and only once per cell cycle. Although the bulk of the genome is copied during the S phase of the cell cycle, increasing evidence suggests that parts of the genome are replicated in G2 or mitosis
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Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-02-09 Yuan Li, Silei Sui, Ajay Goel
Gastrointestinal (GI) cancers, including colorectal, gastric, esophageal, pancreatic, and liver, are associated with high mortality and morbidity rates worldwide. One of the underlying reasons for the poor survival outcomes in patients with these malignancies is late disease detection, typically when the tumor has already advanced and potentially spread to distant organs. Increasing evidence indicates
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The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-02-01 Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, and cancer development, with a specific emphasis on how obesity-driven changes affect the regulation of autophagy and subsequent implications for cancer risk. The burgeoning epidemic
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Special issue on “Excess body weight and cancer: Novel biologic insights and challenges” Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-01-24 Maria Dalamaga, Nikolaos Spyrou
Abstract not available
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Corrigendum to “Microbe-based therapies for colorectal cancer: Advantages and limitations” [Semin. Cancer Biol. 86 (2022) 652–665] Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-01-16 M. Saeed, A. Shoaib, R. Kandimalla, S. Javed, A. Almatroudi, R. Gupta, F. Aqil
Abstract not available
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Editorial: Regulating cell cycle-related activities: The right target for cancer therapy Semin. Cancer Biol. (IF 14.5) Pub Date : 2024-01-12 Hang Fai Kwok
Abstract not available
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Deregulated transcription factors in the emerging cancer hallmarks Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-12-18 Adria Hasan, Naushad Ahmad Khan, Shahab Uddin, Abdul Q. Khan, Martin Steinhoff
Cancer progression is a multifaceted process that entails several stages and demands the persistent expression or activation of transcription factors (TFs) to facilitate growth and survival. TFs are a cluster of proteins with DNA-binding domains that attach to promoter or enhancer DNA strands to start the transcription of genes by collaborating with RNA polymerase and other supporting proteins. They
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Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-12-20 Dorian V. Ziegler, Kanishka Parashar, Lluis Fajas
CDK4, along with its regulatory subunit, cyclin D, drives the transition from G1 to S phase, during which DNA replication and metabolic activation occur. In this canonical pathway, CDK4 is essentially a transcriptional regulator that acts through phosphorylation of retinoblastoma protein (RB) and subsequent activation of the transcription factor E2F, ultimately triggering the expression of genes involved
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Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-28 Raefa Abou Khouzam, Bassam Janji, Jerome Thiery, Rania Faouzi Zaarour, Ali N. Chamseddine, Hemma Mayr, Pierre Savagner, Claudine Kieda, Sophie Gad, Stéphanie Buart, Jean–Marie Lehn, Perparim Limani, Salem Chouaib
In cancer patients, immune cells are often functionally compromised due to the immunosuppressive features of the tumor microenvironment (TME) which contribute to the failures in cancer therapies. Clinical and experimental evidence indicates that developing tumors adapt to the immunological environment and create a local microenvironment that impairs immune function by inducing immune tolerance and
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Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-29 Claire Beckers, Martin Pruschy, Irene Vetrugno
Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy. Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic tumor cells to ionizing radiation and hypoxia-related treatment resistances. A conventional low-dose fractionated radiotherapy regimen exploits iterative reoxygenation in between the individual fractions, nevertheless
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Epigenetic remodelling under hypoxia Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-28 Roxane Verdikt, Bernard Thienpont
Hypoxia is intrinsic to tumours and contributes to malignancy and metastasis while hindering the efficiency of existing treatments. Epigenetic mechanisms play a crucial role in the regulation of hypoxic cancer cell programs, both in the initial phases of sensing the decrease in oxygen levels and during adaptation to chronic lack of oxygen. During the latter, the epigenetic regulation of tumour biology
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Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-28 Gary Altwerger, Maddie Ghazarian, Peter M. Glazer
Hypoxia is a hallmark feature of the tumor microenvironment which can promote mutagenesis and instability. This increase in mutational burden occurs as a result of the downregulation of DNA repair systems. Deficits in the DNA damage response can be exploited to induce cytotoxicity and treat advanced stage cancers. With the advent of precision medicine, agents such as Poly (ADP-ribose) polymerase (PARP)
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Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-28 Harald Schuhwerk, Thomas Brabletz
TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all hallmarks of cancer, the multifunctional DDR mostly orchestrates cell cycle progression, DNA repair, chromatin remodeling and cell death. One oncogenic effect of TGFβ is the partial activation of epithelial-to-mesenchymal transition
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Mathematical modeling of cardio-oncology: Modeling the systemic effects of cancer therapeutics on the cardiovascular system Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-17 Camara L. Casson, Sofia A. John, Meghan C. Ferrall-Fairbanks
Cardiotoxicity is a common side-effect of many cancer therapeutics; however, to-date there has been very little push to understand the mechanisms underlying this group of pathologies. This has led to the emergence of cardio-oncology, a field of medicine focused on understanding the effects of cancer and its treatment on the human heart. Here, we describe how mechanistic modeling approaches have been
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Application of artificial intelligence in oncology Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-15 Xuelei Ma, Qi Zhao
Abstract not available
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TGF-β, EMT, and resistance to anti-cancer treatment Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-08 Xuecong Wang, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in embryonic development, wound-healing, and immune homeostasis. Yet, during tumor progression, these TGF-β-mediated programs are altered, leading to epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through epithelial-to-mesenchymal transition (EMT), a critical developmental
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Thinking small to win big? A critical review on the potential application of extracellular vesicles for biomarker discovery and new therapeutic approaches in pancreatic cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-11 Mahrou Vahabi, Annalisa Comandatore, Chiara Centra, Giovanni Blandino, Luca Morelli, Elisa Giovannetti
Pancreatic ductal adenocarcinoma (PDAC) is an extremely deadly form of cancer, with limited progress in 5-year survival rates despite significant research efforts. The main challenges in treating PDAC include difficulties in early detection, and resistance to current therapeutic approaches due to aggressive molecular and microenvironment features. These challenges emphasize the importance of identifying
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Hypoxia signaling and metastatic progression Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-04 Luana Schito, Sergio Rey-Keim
Disruption of oxygen homeostasis, resulting from an imbalance between O2 supply and demand during malignant proliferation, leads to the development of hypoxic tumor microenvironments that promote the acquisition of aggressive cancer cell phenotypes linked to metastasis and patient mortality. In this review, the mechanistic links between tumor hypoxia and metastatic progression are presented. Current
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Obesity associated pancreatic ductal adenocarcinoma: Therapeutic challenges Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-11-04 Mundla Srilatha, Ramarao Malla, Megha Priya Adem, Jeremy B. Foote, Ganji Purnachandra Nagaraju
Obesity is a prominent health issue worldwide and directly impacts pancreatic health, with obese individuals exhibiting a significant risk for increasing pancreatic ductal adenocarcinoma (PDAC). Several factors potentially explain the increased risk for the development of PDAC, including obesity-induced chronic inflammation within and outside of the pancreas, development of insulin resistance and metabolic
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From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-10-16 Rosemary J. Akhurst
Epithelial-to-mesenchymal transition or transformation (EMT) is a cell shape-changing process that is utilized repeatedly throughout embryogenesis and is critical to the attainment of a precise body plan. In the adult, EMT is observed under both normal and pathological conditions, such as during normal wounding healing, during development of certain fibrotic states and vascular anomalies, as well as
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Extracellular vesicles as a potential delivery platform for CRISPR-Cas based therapy in epithelial ovarian cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-10-10 Nihar Godbole, Alexander Quinn, Flavio Carrion, Emanuele Pelosi, Carlos Salomon
Ovarian Cancer (OC) is the most common gynecological malignancy and the eighth most diagnosed cancer in females worldwide. Presently, it ranks as the fifth leading cause of cancer-related mortality among patients globally. Major factors contributing to the lethality of OC worldwide include delayed diagnosis, chemotherapy resistance, high metastatic rates, and the heterogeneity of subtypes. Despite
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One label is all you need: Interpretable AI-enhanced histopathology for oncology Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-10-11 Thomas E. Tavolara, Ziyu Su, Metin N. Gurcan, M. Khalid Khan Niazi
Artificial Intelligence (AI)-enhanced histopathology presents unprecedented opportunities to benefit oncology through interpretable methods that require only one overall label per hematoxylin and eosin (H&E) slide with no tissue-level annotations. We present a structured review of these methods organized by their degree of verifiability and by commonly recurring application areas in oncological characterization
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Transcriptional regulation of EMT transcription factors in cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-10-05 Masao Saitoh
The epithelial–mesenchymal transition (EMT) is one of the processes by which epithelial cells transdifferentiate into mesenchymal cells in the developmental stage, known as “complete EMT.” In epithelial cancer, EMT, also termed “partial EMT,” is associated with invasion, metastasis, and resistance to therapy, and is elicited by several transcription factors, frequently referred to as EMT transcription
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Dynamical hallmarks of cancer: Phenotypic switching in melanoma and epithelial-mesenchymal plasticity Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-10-01 Paras Jain, Maalavika Pillai, Atchuta Srinivas Duddu, Jason A. Somarelli, Yogesh Goyal, Mohit Kumar Jolly
Phenotypic plasticity was recently incorporated as a hallmark of cancer. This plasticity can manifest along many interconnected axes, such as stemness and differentiation, drug-sensitive and drug-resistant states, and between epithelial and mesenchymal cell-states. Despite growing acceptance for phenotypic plasticity as a hallmark of cancer, the dynamics of this process remains poorly understood. In
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Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-30 Yuting Jiang, Chengdi Wang, Shengtao Zhou
As data-driven science, artificial intelligence (AI) has paved a promising path toward an evolving health system teeming with thrilling opportunities for precision oncology. Notwithstanding the tremendous success of oncological AI in such fields as lung carcinoma, breast tumor and brain malignancy, less attention has been devoted to investigating the influence of AI on gynecologic oncology. Hereby
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Excess body weight and postmenopausal breast cancer: Emerging molecular mechanisms and perspectives Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-20 Daniela Nahmias-Blank, Ofra Maimon, Amichay Meirovitz, Kim Sheva, Tamar Peretz-Yablonski, Michael Elkin
Postmenopausal, obese women have a significantly higher risk of developing estrogen receptor-positive (ER+) breast tumors, that are resistant to therapies and are associated with higher recurrence and death rates. The global prevalence of overweight/obese women has reached alarming proportions and with postmenopausal ER+ breast carcinoma (BC) having the highest incidence among the three obesity-related
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Immune evasion on the nanoscale: Small extracellular vesicles in pancreatic ductal adenocarcinoma immunity Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-23 Jordan Fyfe, Danielle Dye, Norbaini Binti Abdol Razak, Pat Metharom, Marco Falasca
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer alarmingly expanding in our modern societies that is still proving to be very challenging to counteract. This disease constitutes a quintessential example of the multiple interactions existing between the tumour and its surrounding microenvironment. In particular, PDAC is characterized by a very immunosuppressive environment that favours cancer
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Targeting intratumoral hypoxia to enhance anti-tumor immunity Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-16 Gregg L. Semenza
Cancers express a large battery of genes by which they establish an immunosuppressive tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through transcriptional activation mediated by hypoxia-inducible factors HIF-1 and HIF-2. This review summarizes several recent reports describing hypoxia-induced mechanisms of immune evasion in sarcoma and breast, colorectal, hepatocellular
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Recent advancements in artificial intelligence for breast cancer: Image augmentation, segmentation, diagnosis, and prognosis approaches Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-12 Jiadong Zhang, Jiaojiao Wu, Xiang Sean Zhou, Feng Shi, Dinggang Shen
Breast cancer is a significant global health burden, with increasing morbidity and mortality worldwide. Early screening and accurate diagnosis are crucial for improving prognosis. Radiographic imaging modalities such as digital mammography (DM), digital breast tomosynthesis (DBT), magnetic resonance imaging (MRI), ultrasound (US), and nuclear medicine techniques, are commonly used for breast cancer
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Special issue: Deregulated transcription factors in the cancer therapeutic challenges: An update on cancer stemness features Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-09-09 Abdul Quaiyoom Khan
Abstract not available
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Advances in biology and novel treatments of SCLC Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-08-21 Tian Li, Giuseppe Giaccone
Abstract not available
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Proactive and reactive roles of TGF-β in cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-08-11 Nick A. Kuburich, Thiru Sabapathy, Breanna R. Demestichas, Joanna Joyce Maddela, Petra den Hollander, Sendurai A. Mani
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate them into specialized cell types to contribute to tissue development, growth, and repair. Cancer cells can also exhibit plasticity and acquire properties that enhance their survival. TGF-β is an unrivaled growth factor
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Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-08-04 Enrique Almanza-Aguilera, Ainara Cano, Mercedes Gil-Lespinard, Nerea Burguera, Raul Zamora-Ros, Antonio Agudo, Marta Farràs
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Artificial intelligence-based radiomics in bone tumors: Technical advances and clinical application Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-07-26 Yichen Meng, Yue Yang, Miao Hu, Zheng Zhang, Xuhui Zhou
Radiomics is the extraction of predefined mathematic features from medical images for predicting variables of clinical interest. Recent research has demonstrated that radiomics can be processed by artificial intelligence algorithms to reveal complex patterns and trends for diagnosis, and prediction of prognosis and response to treatment modalities in various types of cancer. Artificial intelligence
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Multifaceted effects of obesity on cancer immunotherapies: Bridging preclinical models and clinical data Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-07-26 Logan V. Vick, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Obesity, defined by excessive body fat, is a highly complex condition affecting numerous physiological processes, such as metabolism, proliferation, and cellular homeostasis. These multifaceted effects impact cells and tissues throughout the host, including immune cells as well as cancer biology. Because of the multifaceted nature of obesity, common parameters used to define it (such as body mass index
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The promising application of cell-cell interaction analysis in cancer from single-cell and spatial transcriptomics Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-07-15
Cell-cell interactions instruct cell fate and function. These interactions are hijacked to promote cancer development. Single-cell transcriptomics and spatial transcriptomics have become powerful new tools for researchers to profile the transcriptional landscape of cancer at unparalleled genetic depth. In this review, we discuss the rapidly growing array of computational tools to infer cell-cell interactions
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Enhancing head and neck tumor management with artificial intelligence: Integration and perspectives Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-07-18 Nian-Nian Zhong, Han-Qi Wang, Xin-Yue Huang, Zi-Zhan Li, Lei-Ming Cao, Fang-Yi Huo, Bing Liu, Lin-Lin Bu
Head and neck tumors (HNTs) constitute a multifaceted ensemble of pathologies that primarily involve regions such as the oral cavity, pharynx, and nasal cavity. The intricate anatomical structure of these regions poses considerable challenges to efficacious treatment strategies. Despite the availability of myriad treatment modalities, the overall therapeutic efficacy for HNTs continues to remain subdued
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Harnessing computational spatial omics to explore the spatial biology intricacies Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-07-02 Zhiyuan Yuan, Jianhua Yao
Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our understanding of intricate tissue architectures. However, this rapidly expanding field produces a wealth of diverse and voluminous data, necessitating the evolution of sophisticated computational strategies to unravel inherent patterns. Two distinct methodologies, gene spatial pattern recognition (GSPR) and tissue spatial pattern
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The emerging regulatory roles of non-coding RNAs associated with glucose metabolism in breast cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-25 Samarth Kansara, Agrata Singh, Abhishesh Kumar Badal, Reshma Rani, Prakash Baligar, Manoj Garg, Amit Kumar Pandey
Altered energy metabolism is one of the hallmarks of tumorigenesis and essential for fulfilling the high demand for metabolic energy in a tumor through accelerating glycolysis and reprogramming the glycolysis metabolism through the Warburg effect. The dysregulated glucose metabolic pathways are coordinated not only by proteins coding genes but also by non-coding RNAs (ncRNAs) during the initiation
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Accelerating antibody discovery and design with artificial intelligence: Recent advances and prospects Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-22 Ganggang Bai, Chuance Sun, Ziang Guo, Yangjing Wang, Xincheng Zeng, Yuhong Su, Qi Zhao, Buyong Ma
Therapeutic antibodies are the largest class of biotherapeutics and have been successful in treating human diseases. However, the design and discovery of antibody drugs remains challenging and time-consuming. Recently, artificial intelligence technology has had an incredible impact on antibody design and discovery, resulting in significant advances in antibody discovery, optimization, and developability
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Artificial intelligence in digital pathology of cutaneous lymphomas: a review of the current state and future perspectives Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-17 Thom Doeleman, Liesbeth M. Hondelink, Maarten H. Vermeer, Marijke R. van Dijk, Anne M.R. Schrader
Primary cutaneous lymphomas (CLs) represent a heterogeneous group of T-cell lymphomas and B-cell lymphomas that present in the skin without evidence of extracutaneous involvement at time of diagnosis. CLs are largely distinct from their systemic counterparts in clinical presentation, histopathology, and biological behavior and, therefore, require different therapeutic management. Additional diagnostic
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Artificial intelligence-aided optical imaging for cancer theranostics Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-10 Mengze Xu, Zhiyi Chen, Junxiao Zheng, Qi Zhao, Zhen Yuan
The use of artificial intelligence (AI) to assist biomedical imaging have demonstrated its high accuracy and high efficiency in medical decision-making for individualized cancer medicine. In particular, optical imaging methods are able to visualize both the structural and functional information of tumors tissues with high contrast, low cost, and noninvasive property. However, no systematic work has
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Physiological and environmental factors affecting cancer risk and prognosis in obesity Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-08 Paul F. Seke Etet, Lorella Vecchio, Armel H. Nwabo Kamdje, Patrice N. Mimche, Alfred K. Njamnshi, Abdu Adem
Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term imbalance between energy intake and expenditure. Available epidemiological and clinical data strongly support the links between obesity and certain cancers. Emerging clinical and experimental findings have improved our understanding of the roles of key players in obesity-associated carcinogenesis such as age
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Obesity and renal cell carcinoma: Biological mechanisms and perspectives Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-06-05 Neha Venkatesh, Alberto Martini, Jennifer L. McQuade, Pavlos Msaouel, Andrew W. Hahn
Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many studies have identified an association between obesity and improved survival after diagnosis of RCC, a potential “obesity paradox.” Clinically, there is uncertainty whether improved outcomes observed after diagnosis are
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Current knowledge of small cell lung cancer transformation from non-small cell lung cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-26 Giuseppe Giaccone, Yongfeng He
Lung cancer is the leading cause of cancer related death, and is divided into two major histological subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Histological transformation from NSCLC to SCLC has been reported as a mechanism of treatment resistance in patients who received tyrosine kinase inhibitors (TKIs) targeting EGFR, ALK and ROS1 or immunotherapies. The transformed
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A systems and computational biology perspective on advancing CAR therapy Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-30 Vardges Tserunyan, Stacey D. Finley
In the recent decades, chimeric antigen receptor (CAR) therapy signaled a new revolutionary approach to cancer treatment. This method seeks to engineer immune cells expressing an artificially designed receptor, which would endue those cells with the ability to recognize and eliminate tumor cells. While some CAR therapies received FDA approval and others are subject to clinical trials, many aspects
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Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-22 Rohit Sarkar, Zhihong Xu, Chamini J. Perera, Minoti V. Apte
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is characterised by a prominent collagenous stromal reaction/desmoplasia surrounding tumour cells. Pancreatic stellate cells (PSCs) are responsible for the production of this stroma and have been shown to facilitate PDAC progression. Recently, extracellular vesicles (EVs), in particular, small extracellular vesicles (exosomes)
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Advancements in Small Cell Lung Cancer Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-24 Jung-hoon Lee, Ashish Saxena, Giuseppe Giaccone
Small cell lung cancer (SCLC) is a recalcitrant cancer with an urgent need for novel therapeutics, preclinical models, and elucidation of the molecular pathways responsible for its rapid resistance. Recently, there have been many significant advancements in our knowledge of SCLC that led to the development of novel treatments. This review will go over the recent attempts to provide new molecular subcategorization
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Radiomics and artificial intelligence for precision medicine in lung cancer treatment Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-19 Mitchell Chen, Susan J. Copley, Patrizia Viola, Haonan Lu, Eric O. Aboagye
Lung cancer is the leading cause of cancer-related deaths worldwide. It exhibits, at the mesoscopic scale, phenotypic characteristics that are generally indiscernible to the human eye but can be captured non-invasively on medical imaging as radiomic features, which can form a high dimensional data space amenable to machine learning. Radiomic features can be harnessed and used in an artificial intelligence
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Sanitation enzymes: Exquisite surveillance of the noncanonical nucleotide pool to safeguard the genetic blueprint Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-19 Kirsten Broderick, Mohamed Taha Moutaoufik, Khaled A. Aly, Mohan Babu
Reactive oxygen species (ROS) are common products of normal cellular metabolism, but their elevated levels can result in nucleotide modifications. These modified or noncanonical nucleotides often integrate into nascent DNA during replication, causing lesions that trigger DNA repair mechanisms such as the mismatch repair machinery and base excision repair. Four superfamilies of sanitization enzymes
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Tumor-derived nanoseeds condition the soil for metastatic organotropism Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-12 Mengying Hu, Candia M. Kenific, Nancy Boudreau, David Lyden
Primary tumors secrete a variety of factors to turn distant microenvironments into favorable and fertile ‘soil’ for subsequent metastases. Among these ‘seeding’ factors that initiate pre-metastatic niche (PMN) formation, tumor-derived extracellular vesicles (EVs) are of particular interest as tumor EVs can direct organotropism depending on their surface integrin profiles. In addition, EVs also contain
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Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-06 Miriam Lee-Rueckert, Marina Canyelles, Mireia Tondo, Noemi Rotllan, Petri T. Kovanen, Vicenta Llorente-Cortes, Joan Carles Escolà-Gil
Obesity has been closely related to cancer progression, recurrence, metastasis, and treatment resistance. We aim to review recent progress in the knowledge on the obese macroenvironment and the generated adipose tumor microenvironment (TME) inducing lipid metabolic dysregulation and their influence on carcinogenic processes. Visceral white adipose tissue expansion during obesity exerts systemic or
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Connecting the dots in the associations between diet, obesity, cancer, and microRNAs Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-06 Kurataka Otsuka, Hiroshi Nishiyama, Daisuke Kuriki, Naoki Kawada, Takahiro Ochiya
The prevalence of obesity has reached pandemic levels worldwide, leading to a lower quality of life and higher health costs. Obesity is a major risk factor for noncommunicable diseases, including cancer, although obesity is one of the major preventable causes of cancer. Lifestyle factors, such as dietary quality and patterns, are also closely related to the onset and development of obesity and cancer
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Nonalcoholic fatty liver disease and hepatocellular carcinoma:Insights in epidemiology, pathogenesis, imaging, prevention and therapy Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-05-04 Stergios A. Polyzos, Lampros Chrysavgis, Ilias D. Vachliotis, Evangelos Chartampilas, Evangelos Cholongitas
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Obesity-induced thymic involution and cancer risk Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-04-22 Maria K. Lagou, George S. Karagiannis
Declining thymic functions associated either with old age (i.e., age-related thymic involution), or with acute involution as a result of stress, infectious disease, or cytoreductive therapies (e.g., chemotherapy/radiotherapy), have been associated with cancer development. A key mechanism underlying such increased cancer risk is the thymus-dependent debilitation of adaptive immunity, which is responsible
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Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-04-26 Zhe Wang, Yang Liu, Xing Niu
Gastric cancer is a leading contributor to cancer incidence and mortality globally. Recently, artificial intelligence approaches, particularly machine learning and deep learning, are rapidly reshaping the full spectrum of clinical management for gastric cancer. Machine learning is formed from computers running repeated iterative models for progressively improving performance on a particular task. Deep
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Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-04-15 Tetsuro Watabe, Kazuki Takahashi, Kristian Pietras, Yasuhiro Yoshimatsu
Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known
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Insight into the transcription factors regulating Ischemic stroke and glioma in response to shared stimuli Semin. Cancer Biol. (IF 14.5) Pub Date : 2023-04-11 Arshi Waseem, Sumaiya Rashid, Khalid Rashid, Mohsin Ali Khan, Rehan Khan, Rizwanul Haque, Pankaj Seth, Syed Shadab Raza
Cerebral ischemic stroke and glioma are the two leading causes of patient mortality globally. Despite physiological variations, 1 in 10 people who have an ischemic stroke go on to develop brain cancer, most notably gliomas. In addition, glioma treatments have also been shown to increase the risk of ischemic strokes. Stroke occurs more frequently in cancer patients than in the general population, according