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Identification of ANKRD13D as a potential target in renal cell carcinomas Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-03-07 Wenqian Zhou, Yonghe Huang, Jing Liu, Yiguo Liu, Yuqing Liu, Chen Yu
BackgroundThe correlation of the expression of ankyrin repeat domain (ANKRD) family members with renal cell carcinoma prognosis was investigated.MethodsThe GEPIA2, GEO2R, UALCAN, GDC, OncoLnc, TIMER, PanglaoDB, CancerSEA, and Tabula Muris databases were used. Twelve ANKRD family members were identified as having overexpressed renal cell carcinoma samples. The ANKRD13D was identified as a renal cell
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Screening out molecular pathways and prognostic biomarkers of ultraviolet-mediated melanoma through computational techniques Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-02-27 Md. Arju Hossain, Asif Ahsan, Md. Imran Hasan, Md Sohel, Md. Arif Khan, Pratul Dipta Somadder, Sumaiya Monjur, Md Sipon Miah, K. M. Kaderi Kibria, Kawsar Ahmed, Md Habibur Rahman
PurposeUltraviolet radiation causes skin cancer, but the exact mechanism by which it occurs and the most effective methods of intervention to prevent it are yet unknown. For this purpose, our study will use bioinformatics and systems biology approaches to discover potential biomarkers of skin cancer for early diagnosis and prevention of disease with applicable clinical treatments.MethodsThis study
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Cytokine and soluble programmed death-ligand 1 levels in serum and plasma of cancer patients treated with immunotherapy: Preanalytical and analytical considerations Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-02-26 Elia Cappelletto, Laura Tiozzo Fasiolo, Valentina Salizzato, Luisa Piccin, Alessio Fabozzi, Anna Contato, Paola Del Bianco, Giulia Pasello, Vanna Chiarion-Sileni, Massimo Gion, Aline S. C. Fabricio
AimTo evaluate cytokine and soluble programmed death ligand-1 (sPD-L1) levels in the serum and plasma of cancer patients treated with immunotherapy, and to test different assays.MethodsThree Luminex xMAP assays and two ELLA microfluidic cartridges were used to screen 28 immune-related biomarkers in 38 paired serum and citrate-theophylline-adenosine-dipyridamole (CTAD) plasma samples collected from
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Clinical significance of KRT7 in bladder cancer prognosis Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-02-07 Jun Song, Ye Wu, Zhongming Chen, Dong Zhai, Chunpei Zhang, Shizhan Chen
BackgroundTypically, the overexpressed keratin 7 (KRT7) is considered a validated therapeutic target and prognosis marker in bladder cancer. However, the crucial roles of KRT7 in the clinical prognosis and immune microenvironment in bladder cancer remain unclear.MethodsInitially, the expression levels of KRT7 in public databases were analyzed that is,Tumor Immune Estimation Resource (TIMER) 2.0 and
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Application of a nomogram from coagulation-related biomarkers and C1q and total bile acids in distinguishing advanced and early-stage lung cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-02-02 Tingting Long, Xinyu Zhu, Dongling Tang, Huan Li, Pingan Zhang
BackgroundThis study aimed to establish a nomogram to distinguish advanced- and early-stage lung cancer based on coagulation-related biomarkers and liver-related biomarkers.MethodsA total of 306 patients with lung cancer and 172 patients with benign pulmonary disease were enrolled. Subgroup analyses based on histologic type, clinical stage, and neoplasm metastasis status were carried out and multivariable
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Nomogram for predicting neutropenia in patients with esophageal, gastric, or colorectal cancer treated by chemotherapy in the first cycle Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-01-31 Tian Tian, Wenjun Hu, Jiqing Hao
ObjectivesDevelopment and validation of a predictive model including serum vitamin concentration to estimate the risk of chemotherapy-induced grade 3/4 neutropenia in esophageal cancer, gastric cancer, or colorectal cancer patients who receive the first cycle of chemotherapy.MethodsData from 535 patients treated at the Affiliated Fuyang People's Hospital of Anhui Medical University from January 1,
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Worth of pan-immune-inflammation value in trismus prediction after concurrent chemoradiotherapy for nasopharyngeal carcinomas Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-01-09 Efsun Somay, Busra Yilmaz, Erkan Topkan, Beyza Sirin Ozdemir, Duriye Ozturk, Ali Ayberk Besen, Huseyin Mertsoylu, Ugur Selek
ObjectiveRadiation-induced trismus (RIT), one of the rare but serious side effects of concurrent chemoradiotherapy (C-CRT), is difficult to predict with high accuracy. We aimed to examine whether the pretreatment pan-immune-inflammation value (PIV) measures predict RIT in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving C-CRT.MethodsData of patients with LA-NPC who underwent
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HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2024-01-05 Amani Attia, Awatef Lagha, Amel Mezlini, Ezzedine Ghazouani, Besma Yacoubi-Loueslati, Imene Namouchi
BackgroundColon cancer (CC) is one of the most common malignancies worldwide. Characterization of new prognostic biomarkers for right-sided CC (RCC) and left-sided CC (LCC) may contribute to improving early detection. An association of human leukocyte antigens class II (HLA-II) with the predisposition to CC was suggested.Aim of the studyWe evaluated the association of DRB1 and DQB1 with the risk of
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The value of a three-microRNA panel in serum for prostate cancer screening. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-11-13 Shengjie Lin,Chen Sun,Rongkang Li,Chong Lu,Xinji Li,Zhenyu Wen,Zhenjian Ge,Wenkang Chen,Yingqi Li,Hang Li,Yongqing Lai
BACKGROUND Globally, prostate cancer is the second most common malignancy in males. Serum microRNAs (miRNAs) may function as non-invasive and innovative biomarkers for various cancers. Our study aimed to determine potential miRNAs for prostate cancer screening. METHODS A three-stage study was accomplished to ascertain crucial miRNAs as markers. In the screening stage, we searched PubMed for aberrantly
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Potential prognostic biomarkers of hepatocellular carcinoma based on 4D label-free quantitative proteomics analysis pilot investigation. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-11-13 Lida Suo,Xiangnan Liang,Weibin Zhang,Mingwei Gao,Taiheng Ma,Daosheng Hu,Yilin Song,Zhenming Gao
BACKGROUND Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma. METHODS This pilot study used 4D label-free quantitative proteomics to compare the proteomes of hepatocellular carcinoma and adjacent non-tumor tissue. A total of 66,075 peptides, 6363
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Identifying tumor markers-stratified subtypes (CA-125/CA19-9/carcinoembryonic antigen) in cervical adenocarcinoma. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-11-07 Zongkai Zhang,Yin Li,Ying Wu,Rui Bi,Xiaohua Wu,Guihao Ke,Jun Zhu
OBJECTIVE There is a lack of research evaluating the effect of tumor markers for prognosis in cervical adenocarcinoma. We aimed to develop and validate a preoperative tumor-marker-based model including clinicopathological factors to clarify the prognostic value of endocervical adenocarcinoma. METHODS A total of 572 patients with cervical adenocarcinoma who were staged at the International Federation
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Diagnostic value of FOXF1 gene promoter-methylated DNA in the plasma samples of patients with colorectal cancer. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-10-17 Zahra Dastafkan,Nayebali Rezvani,Sabrieh Amini
BACKGROUND Epigenetic modifications such as DNA methylation in the CpG islands of genes occur at a high rate. In this study, we measured the methylation level of the promoter region of the FOXF1 gene as a new blood biomarker for the detection of colorectal cancer in the early stages. METHODS The methylation level of the promoter region of the FOXF1 gene was measured in the plasma samples of 50 colorectal
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Systematic analysis reveals distinct roles of USF family proteins in various cancer types. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-10-17 Xia Liu,Zhuo-Zhi Wang,Shuai Meng,Fenglin Zang,Huilai Zhang,Ju Wang,Yong-Zi Chen
BACKGROUND Upstream stimulatory factors (USFs) are members of the basic helix-loop-helix leucine zipper transcription factor family, including USF1, USF2, and USF3. The first two members have been well studied compared to the third member, USF3, which has received scarce attention in cancer research to date. Despite a recently reported association of its alteration with thyroid carcinoma, its expression
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Association of hypoxia-inducible factor 1α expression with susceptibility to hepatitis B virus-related hepatocellular carcinoma: A meta-analysis. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-10-03 Lei Wang,Jin-Lin Peng
Hypoxia-inducible factor 1α (HIF-1α) triggers tumorigenesis and progression in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Inconsistent findings have been reported on the influence of HIF-1α over-expression on the clinical outcomes of HBV-related HCC. This study aims to clarify the role of HIF-1α overexpression in the tumorigenesis and prognosis of HBV-induced HCC. Systematic and
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The clinical and pathological significance of increased expression of the cannabinoid receptors CB-1R and CB-2R in patients with papillary thyroid carcinomas compared to benign thyroid lesions. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-09-13 Damla Zeynep Doyuran,Ömer Eronat
INTRODUCTION Papillary thyroid carcinoma is the most common malignancy of the endocrine system. Most papillary thyroid carcinoma patients enjoy excellent outcomes. However, in patients with biologically aggressive features, additional prognostic and predictive data may aid disease management. Dysregulation of the endocannabinoid system including the cannabinoid receptors 1 and 2 (CB-1R and CB-2R) during
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A diagnostic biomarker of acid glycoprotein 1 for distinguishing malignant from benign pulmonary lesions. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-09-01 Ying Chen,Yueyang Zhang,Ankang Huang,Yongsheng Gong,Weidong Wang,Jicheng Pan,Yanxia Jin
BACKGROUND The acid glycoprotein 1 (AGP1) is downregulated in lung cancer. However, the performance of AGP1 in distinguishing benign from malignant lung lesions is still unknown. METHODS The expression of AGP1 in benign diseases and lung cancer samples was detected by Western blot. The receiver operating characteristic curves, bivariate correlation, and multivariate analysis was analyzed by SPSS software
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Effects of coagulation function indicators and tumor markers on diagnosis and clinicopathological characteristics of endometrial cancer. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-08-27 Huayan Li,Huifeng Liao,Bilin Jing,Yifeng Wang
BACKGROUND Endometrial cancer is currently the prevalent malignant cancer worldwide. Diagnostic efficiency of tumor markers is limited, and coagulation function indicators in endometrial cancer are less concerned. METHODS This study attempted to evaluate the effects of coagulation function indicators and tumor markers on the clinical diagnosis and clinicopathological characteristics of patients with
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Diagnostic value of programmed cell death-ligand 1 expression on circulating tumor cells in lung cancer: A systematic review and meta-analysis. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-08-07 Meng Cui,Zhiyong Wan,Jia Yang,Dan Liao,Yang Yang,Yin Xiang
BACKGROUND The expression of programmed cell death-ligand 1 (PD-L1) on circulating tumor cells offers a noninvasive method for the detection of PD-L1 expression in lung cancer, and could serve as a potential surrogate for cancer tissue. However, discrepant results make it difficult to apply PD-L1 on circulating tumor cells to clinical practice. Therefore, we conducted a meta-analysis to investigate
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Immune checkpoints as potential theragnostic biomarkers for epithelial ovarian cancer. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-07-30 Azza Habel,Xu Weili,Mariem Hadj Ahmed,Mouna Stayoussef,Hanen Bouaziz,Mouna Ayadi,Amel Mezlini,Anis Larbi,Basma Yaacoubi-Loueslati
BACKGROUND Epithelial ovarian cancer (EOC) is the leading cause of death associated with gynecologic tumors. EOC is asymptomatic in early stages, so most patients are not diagnosed until late stages, highlighting the need to develop new diagnostic biomarkers. Mediators of the tumoral microenvironment may influence EOC progression and resistance to treatment. AIM To analyze immune checkpoints to evaluate
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Prognostic significance of N6-methyladenosine-modified related chemotransferase METTL3 in gastric carcinoma: Evidence from meta-analysis. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-07-02 Chenglou Zhu,Qiong Wu,Yan Xu,Jichun Ma,Yongli Hu,Junhong Wang,Zhenhua Gao,Mingxu Da
BACKGROUND N6-methyladenosine (m6A) methylation is known as the research hotspot for tumor epimodification, and its associated methyltransferase-like3 (METTL3) is significantly differentially expressed in gastric carcinoma, but its clinical value has not been summarized. This meta-analysis aimed to evaluate the prognostic significance of METTL3 in gastric carcinoma. MATERIAL AND METHODS Databases,
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NRF2/HO-1 axis, BIRC5, and TP53 expression in ESCC and its correlation with clinical pathological characteristics and prognosis. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-06-14 Yongmei Gao,Li Wan,Mengyan Li,Bo Wang,Yuqing Ma
BACKGROUND Many types of cancer exhibit high nuclear factor erythroid 2-related factor 2 (NRF2), which is effective in resisting drugs and radiation. However, the role of NRF2 gene expression in predicting the prognosis of esophageal squamous cell carcinoma (ESCC) remains unclear. METHODS The association between NRF2, heme oxygenase-1 (HO-1), baculovirus IAP repeat 5 (BIRC5), P53 gene expression levels
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Ensuring efficient development of personalized medicine by addressing regulatory needs: What role can research infrastructures play? Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-06-05 Francesca Capone,David Morrow,Franca Moretti
Personalized Medicine is a novel medical practice that uses an individual's genetic profile to guide decisions made regarding the prevention, diagnosis, and treatment of disease. Knowledge of a patient's genetic profile is crucial to support doctors in selecting the proper therapy and administer it using the correct dose or regimen. Personalized Medicine is a great opportunity to turn the "one size
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Gleason Score-related MT1L as biomarker for prognosis in prostate adenocarcinoma and contribute to tumor progression in vitro. Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-05-16 Lei Liu,Yaping Li,Shiying Tang,Bin Yang,Qiming Zhang,Ruotao Xiao,Xiaofei Hou,Cheng Liu,Lulin Ma
BACKGROUND The Gleason Score is well correlated with biological behavior and prognosis in prostate adenocarcinoma (PRAD). This study was derived to determine the clinical significance and function of Gleason-Score-related genes in PRAD. METHODS RNA-sequencing profiles and clinical data were extracted from the The Cancer Genome Atlas PRAD database. The Gleason-Score-related genes were screened out by
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Effect of secretory DKK3 on circulating CD56bright natural killer cells in patients with liver cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-04-18 Da-Hua Liu, Gui-Min Wen, Chang-Liang Song, Pu Xia
BackgroundLiver cancer seriously threatens human health. Natural killer (NK) cells are an important part of the innate immune system and have strong anti-tumor ability. Immunotherapy based on NK ce...
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Alterations of commensal microbiota are associated with pancreatic cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-04-05 Tian Chen, Xuejiao Li, Gaoming Li, Yun Liu, Xiaochun Huang, Wei Ma, Chao Qian, Jie Guo, Shuo Wang, Qin Qin, Shanrong Liu
BackgroundDysbiosis commonly occurs in pancreatic cancer, but its specific characteristics and interactions with pancreatic cancer remain obscure.Materials and methodsThe 16S rRNA sequencing method...
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MMR markers correlate with clinical outcome in patients with esophageal squamous cell carcinoma Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-04-03 Takuro Yamauchi, Fumiyoshi Fujishima, Junichi Tsunokake, Atsushi Kunimitsu, Ryujiro Akaishi, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Yusuke Taniyama, Takashi Kamei, Ryo Ichinohasama, Hironobu Sasano
BackgroundThe DNA mismatch repair system is one of the defense mechanisms in the body, and the inactivation of mismatch repair plays a pivotal role in secondary carcinogenesis and progression. Howe...
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Pleural CEA, CA-15-3, CYFRA 21-1, CA-19-9, CA-125 discriminating malignant from benign pleural effusions: Diagnostic cancer biomarkers Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-03-21 Farzaneh Fazli Khalaf, Mehrnaz Asadi Gharabaghi, Maryam Balibegloo, Hamidreza Davari, Samaneh Afshar, Behnaz Jahanbin
IntroductionThere is a need for a rapid, accurate, less-invasive approach to distinguishing malignant from benign pleural effusions. We investigated the diagnostic value of five pleural tumor marke...
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Analysis of systemic inflammatory and coagulation biomarkers in advanced cervical cancer: Prognostic and predictive significance Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-03-16 Ningfeng Li, Yan Zhang, Wenjie Qu, Chao Zhang, Zhaoxia Ding, Linlin Wang, Baoxia Cui
ObjectivePeripheral systemic inflammatory, nutritional, and coagulation biomarkers have prognostic and predictive value in various malignancies. We evaluated the prognostic and predictive roles of ...
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Overexpression of complement C5a indicates poor survival and therapeutic response in metastatic renal cell carcinoma Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-03-07 Changjun Yang, Faying Yang, Xiang Chen, Yunpeng Li, Xiaoyi Hu, Jianming Guo, Jiaxi Yao
IntroductionComplement C5a is an important component of the innate immune system. An increasing number of reports have revealed the relevance of C5a in tumor progression; however, its exact role in...
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Overordering of tumor marker for outpatients revealed by performance indicators and the impact of a health policy intervention: An observational study using administrative records Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-02-28 Massimo Gion, Roberto De Gobbi, Manuel Zorzi, Giovanni Carretta, Luca Leonardi, Stefano Guzzinati, Chiara Trevisiol, Maurizio Cancian, Giulia Cardinali, Federica Michieletto, Ruggero Dittadi, Aline S.C. Fabricio, Massimo Rugge, Francesca Russo
PurposeThe overuse of laboratory tests contributes to impair health systems effectiveness, tumor markers (TMs) being a paradigmatic example. In the present study we applied indicators of TMs approp...
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Diagnosis of malignant pleural effusion with combinations of multiple tumor markers: A comparison study of five machine learning models Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-02-27 Yixi Zhang, Jingyuan Wang, Baosheng Liang, Hanyu Wu, Yangyu Chen
BackgroundTo evaluate the diagnostic value of combinations of tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA153, and CA19-9 in identifying malignant pleural effusio...
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Prognostic value of alkaline phosphatase and bone-specific alkaline phosphatase in breast cancer: A systematic review and meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-02-12 Chengying Jiang, Fangke Hu, Xiaoqing Xia, Xiaojing Guo
Numerous studies have reported the clinical value of alkaline phosphatase (ALP) and its bone-specific isoforms (bone-specific alkaline phosphatase (BAP)) in breast cancer. The purpose of this meta-...
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The relationship between connexin-43 expression and Ki67 in non-glial central nervous system tumors Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-02-01 Aleksandrs Krigers, Patrizia Moser, Helga Fritsch, Matthias Demetz, Johannes Kerschbaumer, Konstantin R. Brawanski, Claudius Thomé, Christian F. Freyschlag
BackgroundAdvanced intercellular communication is a known oncogenic factor. In the central nervous system, Connexin-43 (Cx43) forms this junctional networking. Moreover, it correlates with the prol...
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Programmed death-ligand 1 expression in diffuse large B-cell lymphoma is associated with poor prognosis Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-01-09 Esraa Al-Khateeb, Manal A. Abbas, Majd B. Khader, Maher A. Sughayer
BackgroundProgrammed death-ligand 1 (PD-L1) expression in some tumors has prognostic implications. This work aims at investigating PD-L1 expression in diffuse large B-cell lymphoma (DLBCL) and to s...
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Prognostic and clinicopathologic significance of PLIN2 in cancers: A systematic review with meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2023-01-05 Ming-Lin Li, Han-Yong Luo, Zi-Wei Quan, Le-Tian Huang, Jia-He Wang
The relationship between PLIN2 expression and prognosis, and clinicopathological significance of various cancers has been extensively studied, but the results are not completely consistent. This re...
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Diagnostic and prognostic values of MMP-9 expression in ovarian cancer: A study based on bioinformatics analysis and meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-11-29 Changyu Liu, Ying Shen, Qiyan Tan
BackgroundThis study aims to explore the expression of matrix metalloproteinase-9 (MMP-9) associated with both diagnostic and prognostic value in ovarian cancer by meta-analysis and bioinformatics ...
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Plasma metabolomics for the assessment of the progression of non-small cell lung cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-11-14 Yingtian Zhang, Yaping Cheng, Liqiang Qin, Yuanliang Liu, Sijia Huang, Liya Dai, Jialong Tao, Jie Pan, Cunjin Su, Yusong Zhang
ObjectivesNon-small cell lung cancer (NSCLC) is a leading type of lung cancer with a high mortality rate worldwide. Although many procedures for the diagnosis and prognosis assessment of lung cance...
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A software-assisted untargeted liquid chromatography–mass spectrometry method for lipidomic profiling of human plasma samples Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-10-31 Francesco Segrado, Adalberto Cavalleri, Alice Cantalupi, Luigi Mariani, Sonia Dagnino, Vittorio Krogh, Elisabetta Venturelli, Claudia Agnoli
IntroductionIn this paper, an analytical pipeline designed for untargeted lipidomic profiling in human plasma is proposed. The analytical pipeline was developed for case-control studies nested in p...
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A study on the correlation between M2 macrophages and regulatory T cells in the progression of colorectal cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-10-26 Yanlei Chen, Yu Gao, Xueqian Ma, Yanping Wang, Jinhao Liu, Chunyu Yang, Yue Wang, Cuifen Bao, Xiaoyu Song, Yang Feng, Yan Sun, Shifeng Qiao
BackgroundM2 macrophages and regulatory T cells (Tregs) can promote tumors and development by inhibiting the anti-tumor immune response. This study investigated the effect of CD163-positive M2 macr...
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Development and validation of a nomogram involving immunohistochemical markers for prediction of recurrence in early low-risk endometrial cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-10-16 Wei Kong, Yuan Tu, Peng Jiang, Yuzhen Huang, Jingni Zhang, Shan Jiang, Ning Li, Rui Yuan
BackgroundThe purpose of this study was to construct a nomogram based on classical parameters and immunohistochemical markers to predict the recurrence of early low-risk endometrial cancer patients...
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Metabolomic study of serum in patients with invasive ductal breast carcinoma with LC-MS/MS approach Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-09-27 Nasrin Amiri-Dashatan, Reyhaneh Farrokhi Yekta, Mehdi Koushki, Afsaneh Arefi Oskouie, Hadi Esfahani, Salman Taheri, Elham Kazemian
BackgroundInvasive ductal carcinoma (IDC) is the most common type of breast cancer so its early detection can lead to a significant decrease in mortality rate. However, prognostic factors for IDC a...
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Platelet-to-lymphocyte ratio associated with the clinicopathological features and prognostic value of breast cancer: A meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-08-15 Zhixun Gong, Ruomei Xin, Long Li, Liping Lv, Xinni Wu
ObjectiveThe association of platelet-to-lymphocyte ratio (PLR) with the clinicopathological features and prognosis in patients with breast cancer was evaluated.MethodRelated studies were searched f...
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Effect of irradiation on cytokine production in cancer patients Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-08-04 Amichay Meirovitz, Menachem Gross, Shani Cohen, Aron Popovtzer, Vivian Barak
BackgroundIrradiation, which affects cytokine secretion, is used to treat cancer patients. Cytokine levels have correlations to disease parameters, serving as biomarkers for patients. We aim to exp...
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Diagnostic and prognostic value of microRNA-486 in patients with lung cancer: A systematic review and meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-07-28 Xiaoyu Shen, Linlin Li, Linlin Zhang, Wenjing Liu, Yang Wu, Rui Ma
PurposeThere are conflicting opinions on whether miR-486 could be used for cancer diagnosis and prognosis. Therefore, this present study investigated the potential effect of miR-486 on lung cancer ...
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Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-07-25 Jan Philipp Kühn, Florian Bochen, Sandrina Körner, Bernhard Schick, Mathias Wagner, Sigrun Smola, Barbara Berkó-Göttel, Luc G.T. Morris, Jingming Wang, Alessandro Bozzato, Maximilian Linxweiler
IntroductionHead and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lym...
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Comparison of the somatic mutations between circulating tumor DNA and tissue DNA in Chinese patients with non-small cell lung cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-07-06 Meng Zhang, Yi Feng, Changda Qu, Meizhu Meng, Wenmei Li, Meiying Ye, Sisi Li, Shaolei Li, Yuanyuan Ma, Nan Wu, Shuqin Jia
BackgroundNon-invasive liquid biopsies of circulating tumor DNA (ctDNA) is a rapidly growing field in the research of non-small cell lung cancer (NSCLC). In this study, factors affecting the concor...
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FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-07-06 Chenxu Meng, Yang Yang, Pengfei Ren, Qian Ju, Xiangting Jin, Qihe Long, Xiangyu Chen, Xian Wang, Fanfan Li
BackgroundFidgetin-like 1 (FIGNL1) participates in tumor resistance by playing the function of homologous recombination repair(HRR). However, the role of FIGNL1 in non-small cell lung cancer (NSCLC...
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Neutrophil-to-lymphocyte ratio trend: A novel prognostic predictor in patients with nasopharyngeal carcinoma receiving radiotherapy Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-30 Pei Yang, Yu Zhao, Hao Liang, Guanzhi Zhou, Bassem Youssef, Hesham Elhalawani, Meizhen Li, Fengbo Tan, Yi Jin, Hekun Jin, Hong Zhu, Abdallah Sherif Radwan Mohamed, Nantavithya Chonnipa, Danita Kannarunimit, Yingrui Shi, Hui Wang, Clifton David Fuller
BackgroundPeripheral neutrophil-lymphocyte ratio (NLR), reflecting immune-inflammation status, shows great potential for tumor progression and outcome. Pre-treatment NLR does not fully reflect the ...
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Multiple roles of ghrelin in breast cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-28 Yiding Chen, Xuke Han, Lan Wang, Qing Wen, Liufu Li, Lisha Sun, Qiu Chen
Breast cancer is one of the most threatening malignant tumors in women worldwide; hence, investigators are continually performing novel research in this field. However, an accurate prediction of it...
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Clinical significance of chromosomal integrity in gastric cancers Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-19 Rukui Zhang, Zhaorui Liu, Xusheng Chang, Yuan Gao, Huan Han, Xiaona Liu, Hui Cai, Qiqing Fu, Lei Liu, Kai Yin
Background A whole-exome or targeted cancer genes panel by next-generation sequencing has been used widely in assisting individualized treatment decisions. Currently, multiple algorithms are developed to estimate DNA copy numbers based on sequencing data, which makes a comprehensive global glance at chromosomal integrity possible. We aim to classify gastric cancers based on chromosomal integrity to
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ERβ overexpression may not be a direct prognostic factor in patients with NSCLC: A meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-21 Hui Li, Haishegn Chen, Jing Shi, Qing Fan, Zhongxia Zhou, Xiufeng Tang, Yanhong Wang, Yuguo Liu
Overall survival of non-small cell lung cancer (NSCLC) patients remains disappointingly low. The estrogen receptor (ER) was considered a promising therapeutic target for NSCLC. Numerous studies hav...
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The prognostic value of aspartate beta-hydroxylase in early breast cancer Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-20 Paola Barboro, Alessandra Rubagotti, Silvia Poddine, Federica Grillo, Luca Mastracci, Francesco Boccardo
PurposeAspartate beta-hydroxylase (ASPH) is a transmembrane protein involved in cancer progression, which has been shown to imply a worse prognosis in several solid tumors. The aim of the present s...
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Overexpression of GNA13 correlates with poor prognosis in esophageal squamous cell carcinoma after esophagectomy Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-15 Zichun Pan, Zhousan Zheng, Wen Ye, Cui Chen, Sheng Ye
Background This study aimed to explore the expression and clinical implication of guanine nucleotide-binding protein alpha 13 (GNA13) in esophageal squamous cell carcinoma (ESCC). Methods We first employed western blot analysis to test the GNA13 protein expression level in ESCC tissues. Subsequently, we used immunohistochemistry assays to detect the GNA13 in ESCC specimens from 173 patients who underwent
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Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-09 Biwei Luo, Linsen Liu, Jian’gang Bi, Shiyun Bao, Yusen Zhang
Objective This study aimed to investigate the role of the alpha fetoprotein (AFP) ratio before and after radiofrequency ablation (RFA) in the prognosis of patients with liver cancer. Methods A total of 368 patients who underwent RFA for liver cancer in Shenzhen People's Hospital from 2010 to 2020 were randomly divided into the training group and the validation group. Levels of AFP before and after
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Prognostic association between NLRP3 inflammasome expression level and operable pancreatic adenocarcinoma Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-06-09 Lina Zheng, Hailiang Liu
Background The NLRP3 inflammasome is significantly associated with tumor development and metastasis in various malignancies. However, the significance of the NLRP3 inflammasome in pancreatic adenocarcinoma has not been fully determined. Therefore, we try to evaluate the expression of the NLRP3 inflammasome in pancreatic adenocarcinoma and analyzed its prognostic significance. Methods This cohort study
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Diagnostic performance of clusterin in hepatocellular carcinoma: A meta-analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-05-30 Ge Gao, Xuke Luan
Introduction Clusterin (CLU) is a pleiotropic protein with numerous functions. It has recently attracted considerable attention owing to its association with cancer progression and metastasis. However, its role in hepatocellular carcinoma (HCC) has not been investigated. This meta-analysis is the first evaluation of the diagnostic performance of CLU in HCC. Methods Articles published in PubMed, EMBASE
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Catalase C262T genetic variation and cancer susceptibility: A comprehensive meta-analysis with meta-regression and trial sequential analysis Int. J. Biol. Markers (IF 2.0) Pub Date : 2022-05-30 Md Abdul Barek, Sarah Jafrin, Md. Abdul Aziz, Mohammad Safiqul Islam
Background Several genetic association studies have analyzed the link between the catalase (CAT) C262T variant and different cancers, but the findings remain controversial. Our research centered on establishing a comprehensive correlation between the C262T variant and different cancers. Methods This study was conducted using RevMan 5.4 software following the PRISMA 2020 guidelines. For this meta-analysis