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Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2024-02-08 Gehan Hammad, Samah Mamdouh, Dina Mohamed Seoudi, Mohamed Ismail Seleem, Gehan Safwat, Rania Hassan Mohamed
Abstract BACKGROUND: P-Element-induced wimpy testis (PIWI) proteins, when in combination with PIWI-interacting RNA (piRNA), are engaged in the epigenetic regulation of gene expression in germline cells. Different types of tumour cells have been found to exhibit abnormal expression of piRNA, PIWIL-mRNAs, and proteins. We aimed to determine the mRNA expression profiles of PIWIL1, PIWIL2, PIWIL3, & PIWIL4
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Can serum ferritin serve as a biomarker for the prognosis of gynecological malignant tumors? A retrospective cohort study Cancer Biomark. (IF 3.1) Pub Date : 2024-02-08 Weidan Zhang, Qiaoqiao Chen, Yali Cheng, Miao Wang, Jinfei Tong, Rongrong Tang, Yihong Pan, Jianhua Yang
Abstract PURPOSE: It is widely accepted that there is a strong relationship between iron levels and cancer. This study aimed to investigate the relationship between serum ferritin levels and the severity and prognosis of gynecological malignant tumors. METHODS: This retrospective study included patients with gynecological malignant tumors at Sir Run Run Shaw Hospital in the Department of Obstetrics
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PD-1 inhibitor combined with Docetaxel exerts synergistic anti-prostate cancer effect in mice by down-regulating the expression of PI3K/AKT/NFKB-P65/PD-L1 signaling pathway Cancer Biomark. (IF 3.1) Pub Date : 2024-01-17 Sixu Zhou, Baogui Wang, Yingying Wei, Peiru Dai, Yan Chen, Yingyi Xiao, Hongmei Xia, Chunlin Chen, Weihua Yin
Abstract BACKGROUND: Docetaxel is a yew compound antitumor agent with accurate antitumor efficacy, but its application is limited due to the high and serious adverse effects, and finding effective combination therapy options is a viable strategy. Immune checkpoint inhibitors have become hotspots in enhancing anti-tumor immunity by blocking immune checkpoint signaling pathways, but their response rate
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Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters Cancer Biomark. (IF 3.1) Pub Date : 2024-01-16 Luděk Záveský, Eva Jandáková, Vít Weinberger, Luboš Minář, Milada Kohoutová, Ondřej Slanař
Abstract BACKGROUND: Breast cancer is the most commonly occurring cancer worldwide and is the main cause of death from cancer in women. Novel biomarkers are highly warranted for this disease. OBJECTIVE: Evaluation of novel long non-coding RNAs biomarkers for breast cancer. METHODS: The study comprised the analysis of the expression of 71 candidate lncRNAs via screening, six of which (four underexpressed
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miRNA profiling of esophageal adenocarcinoma using transcriptome analysis Cancer Biomark. (IF 3.1) Pub Date : 2024-01-10 Ryan Corlett, Charles Button, Sydney Scheel, Swati Agrawal, Vikrant Rai, Kalyana C. Nandipati
Abstract Esophageal adenocarcinoma (EAC) occurs following a series of histological changes through epithelial-mesenchymal transition (EMT). A variable expression of normal and aberrant genes in the tissue can contribute to the development of EAC through the activation or inhibition of critical molecular signaling pathways. Gene expression is regulated by various regulatory factors, including transcription
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EGFR, HLA-G, CD70, c-MET, and NY-ESO1 as potential biomarkers in high grade epithelial ovarian carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-12-28 Duc Vo, Yan Liu, Anil K. Sood, Katy Rezvani, Amir A. Jazaeri, Jinsong Liu
Abstract High grade epithelial ovarian carcinoma is an aggressive tumor. Treatment includes platinum therapy, however it recurs in most patients due to therapy resistance. In this project, we study the immunohistochemical (IHC) expression of five potential biomarkers/prognostic markers in high grade epithelial ovarian carcinoma: EGFR, HLA-G, CD70, c-MET, and NY-ESO1. A cohort of 274 patients is used
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The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions Cancer Biomark. (IF 3.1) Pub Date : 2023-12-28 Xuan Zhang, Yang-Yang Wu, Yuan-Yuan Qin, Fa-Quan Lin
Abstract OBJECTIVE: This article aims to investigate the clinical value of hemoglobin/red cell distribution width ratio (Hb/RDW), C-reactive protein/albumin ratio (CAR) and plateletcrit (PCT) combined with carcinoembryonic antigen (CEA) in colorectal cancer (CRC) auxiliary diagnosis. METHODS: We retrospectively analyzed in 718 subjects (212 with CRC, 209 with benign colorectal lesions (BCL), 111 with
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The importance of biglycan, decorin and TGF-1 levels in the diagnosis of non-small cell lung cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-12-28 Fatih Karataş, Murat Acat, Hatice Gulsah Karatas, Fatih İnci, Özlem Sengören Dikiş
Abstract BACKGROUND: Despite Non-small cell lung cancer (NSCLC) ranks among the most deadly cancers worldwide, and currently, apart from a low percentage, targetable molecules have not been identified in its etiopathogenesis. The relationship between the proteoglycans decorin and biglycan, which are present in the extracellular matrix of cells, and transforming growth factor Beta-1 (TGF-B1), has been
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KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1 Cancer Biomark. (IF 3.1) Pub Date : 2023-12-28 Xinjian Qu, Chang Xu, Wenbo Yang, Qianqian Li, Simei Tu, Chenghai Gao
Abstract BACKGROUND: Epithelial-mesenchymal transition (EMT) is an important biological process by which malignant tumor cells to acquire migration and invasion abilities. This study explored the role of KLF5 in the EMT process of in cervical cancer cell lines. OBJECTIVE: Krüpple-like factor 5 (KLF5) is a basic transcriptional factor that plays a key role in cell-cycle arrest and inhibition of apoptosis
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Identification of TNFRSF1A as a potential biomarker for osteosarcoma Cancer Biomark. (IF 3.1) Pub Date : 2023-12-21 Yuke Zhang, Kai Liu, Jianzhong Wang
Abstract BACKGROUND: Osteosarcoma (OS) is a relatively rare malignant bone tumor in teenagers; however, its molecular mechanisms are not yet understood comprehensively. OBJECTIVE: The study aimed to use necroptosis-related genes (NRGs) and their relationships with immune-related genes to construct a prognostic signature for OS. METHODS: TARGET-OS was used as the training dataset, and GSE 16091 and
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Subgroup identification of targeted therapy effects on biomarker for time to event data Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Gajendra K. Vishwakarma, Atanu Bhattacharjee, Fatih Tank, Alexander F. Pashchenko
BACKGROUND: The initiation biomarker-driven trials have revolutionized oncology drug development by challenging the traditional phased approach and introducing basket studies. Notable successes in non-small cell lung cancer (NSCLC) with ALK, ALK/ROS1, and EGFR inhibitors have prompted the need to expand this approach to other cancer sites. OBJECTIVES: This study explores the use of dose response modeling
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HPV genotype-specific distribution and attributable risk in cervical intraepithelial neoplasia in a referral population with a history of LSIL Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Sam Ratnam, Dan Jang, Reza Alaghehbandan, Laura Gilbert, Yunwen Xu, Wei Wang, Phillip Andrews, Ashley Green, David J. Speicher, Max Chernesky
BACKGROUND AND OBJECTIVE: CINtec PLUS and cobas HPV tests (Roche) were previously ascertained for triaging an LSIL referral population [1]. As part of this study, genotype-specific distribution and attributable risk of high-risk (HR)-HPV in cervical intraepithelial neoplasia (CIN) were determined.METHODS: Archived cervical specimens in ThinPrep PreservCyt (Hologic Inc) from the LSIL referral population
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Integrative analysis of histone acetyltransferase KAT2A in human cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Hua Li, Chun Li, Lu-Zong Yang, Ji Liu
The high incidence of mutations and the crucial roles of KAT2A in cancer development have received increased attention. Nevertheless, a systematic comparison of the heterogeneity and dynamics across different cancer types has not been conducted. Hence, a deep analysis using public databases was performed to clarify the contributions of KAT2A and its correlation with tumorigenesis. The raw data regarding
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Correlation between IL3 signaling pathway-related genes and immune checkpoint inhibitor efficacy in patients with renal cell carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Shuang Hou, Tianqi Gu, Ying Shi, Yushan Huang, Jiarong Yao, Peng Luo, Manming Cao, Jian Zhang, Anqi Lin, Weiliang Zhu
BACKGROUND: There is a lack of effective biomarkers that predict immunotherapy efficacy in clear cell renal cell carcinoma(KIRC). OBJECTIVE: We aimed to identify biomarkers that would predict the efficacy of KIRC treatment with immune checkpoint inhibitors (ICIs). METHODS: Cohort data of KIRC patients with somatic mutations, mRNA expression and survival data from The Cancer Genome Atlas (TCGA) database
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STEAP3 is a prognostic biomarker that promotes glioma progression by regulating immune microenvironment and PI3K-AKT pathway Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Zihan Song, Zijun Zhao, Siyu Zhu, Qianxu Jin, Yunpeng Shi, Shiyang Zhang, Zairan Wang, Yizheng Wang, Zongmao Zhao
BACKGROUND: STEAP3 is a metal reductase located on the plasma membrane close to the nucleus and vesicles. Despite numerous studies indicating the involvement of STEAP3 in tumor advancement, the prognostic value of STEAP3 in glioma and the related mechanisms have not been fully investigated. METHODS: Initially, we examined the correlation between STEAP3 expression and the survival rate in various glioma
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Identification of the six-hormone secretion-related gene signature as a prognostic biomarker for colon adenocarcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Xiongjie Jia, Tao Zhang, Xinze Lv, Haiwei Du, Yongkun Sun, Yin Guan
BACKGROUND: Colon adenocarcinoma (COAD) is a globally prevalent cancer, with hormone secretion playing a crucial role in its progression. Despite this, there is limited understanding of the impact of hormone secretion on COAD prognosis. This study aimed to establish a prognostic signature based onhormone secretion-related genes and to elucidate the potential functional mechanisms of these genes in
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The clinical value of a nomogram constructed from CEA, CA199, PT, FIB, tumor differentiation and TNM stage in colorectal cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Kang Wang, Lulu Ma, Liying Chen, Yatong Jiang, Ningquan Liu, Jianchun Cai, Yiyao Zhang
BACKGROUND: The accurate Tumor-Node-Metastasis (TNM) staging of colorectal cancer (CRC) is of great guiding significance for the judgment of tumor progression and prognosis, and the formulation of treatment strategies. OBJECTIVE: The aim of this study was to construct a recurrence risk scoring (RRS) system and prognostic prediction model to improve the accuracy of staging, prognosis prediction, and
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The identification of N6-methyladenosine-related miRNAs predictive of hepatocellular carcinoma prognosis and immunotherapy efficacy Cancer Biomark. (IF 3.1) Pub Date : 2023-12-15 Renrui Zou, Yaqian Liu, Sangsang Qiu, Ya Lu, Yan Chen, Hui Yu, Hangju Zhu, Wenbo Zhu, Longbiao Zhu, Jifeng Feng, Jing Han
BACKGROUND: Hepatocellular carcinoma (HCC) has a high degree of malignancy and poor prognosis. N6-methyladenosine (m6A) modifications and microRNAs (miRNAs) play pivotal roles in tumorigenesis and development. However, the role of m6A-related miRNAs in HCC has not been clarified yet. This study aimed to identify the role of m6A-miRNAs in HCC prognosis through bioinformatics analysis. METHODS: The clinicopathological
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GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis Cancer Biomark. (IF 3.1) Pub Date : 2023-12-19 Tianfeng Dang, Jieqing Yu, Yanqing Yu, Junjie Jiang, Yang Shi, Simin Yu, Congli Peng, Xiang Min, Yuanping Xiong, Ping Long, Wensheng Zhou, Daofeng Dai
Abstract GPX4 has attracted much attention as a key molecule of cell ferroptosis, but its role in cell apoptosis is rarely reported, and its role in apoptosis of thyroid cancer (TC) cell has not been reported. The analysis of TCGA database showed that both GPX4 and FKBP8 were highly expressed in TC tumor tissues; The expression of GPX4 and FKBP8 were positively correlated. The immunohistochemical analysis
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Prognostic value and gene regulatory network of CMSS1 in hepatocellular carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-12-19 Cheng Chen, Caiming Wang, Wei Liu, Jiacheng Chen, Liang Chen, Xiangxiang Luo, Jincai Wu
Abstract BACKGROUND: Cms1 ribosomal small subunit homolog (CMSS1) is an RNA-binding protein that may play an important role in tumorigenesis and development. OBJECTIVE: RNA-seq data from the GEPIA database and the UALCAN database were used to analyze the expression of CMSS1 in liver hepatocellular carcinoma (LIHC) and its relationship with the clinicopathological features of the patients. METHODS:
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Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas Cancer Biomark. (IF 3.1) Pub Date : 2023-11-23 Shuang Peng, Hao Zhang, Guoxin Song, Jingfeng Zhu, Shiyu Zhang, Cheng Liu, Feng Gao, Hang Yang, Wei Zhu
Abstract BACKGROUND: Post-transcriptional regulation of mRNA induced by microRNA is known crucial in tumor occurrence, progression, and metastasis. This study aims at identifying significant miRNA-mRNA axes for stomach adenocarcinomas (STAD). METHOD: RNA expression profiles were collected from The Cancer Genome Atlas (TCGA) and GEO database for screening differently expressed RNAs and miRNAs (DE-miRNAs/DE-mRNAs)
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Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression Cancer Biomark. (IF 3.1) Pub Date : 2023-11-23 Qi Li, Min Zhao, Dan-Dan Hu, Jun-Jiao Qin, Wei He
Abstract BACKGROUND: Circular RNAs (circRNAs) are critical regulators of lung adenocarcinoma (LA) progression. Although a molecular marker targeting hsa_circ_0000018 has been developed and used for diagnosing colon cancer, the role of this circRNA in LA progression has not been explored till now. OBJECTIVES: This study aimed to elucidate the role and regulatory mechanisms of hsa_circ_0000018 in LA
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Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model Cancer Biomark. (IF 3.1) Pub Date : 2023-11-23 Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
OBJECTIVES: This study explores a deep learning (DL) approach to predicting bone metastases in breast cancer (BC) patients using clinical information, such as the fat index, and features like Computed Tomography (CT) images. METHODS: CT imaging data and clinical information were collected from 431BC patients who underwent radical surgical resection at Harbin Medical University Cancer Hospital. The
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A clinical spectrum of resectable lung adenocarcinoma with micropapillary component (MPC) concurrently presenting as mixed ground-glass opacity nodules Cancer Biomark. (IF 3.1) Pub Date : 2023-11-18 Ziwen Zhu, Weizhen Jiang, Danhong Zhou, Weidong Zhu, Cheng Chen
Abstract BACKGROUND: In clinical practice, preoperative identification of mixed ground-glass opacity (mGGO) nodules with micropapillary component (MPC) to facilitate the implementation of individualized therapeutic strategies and avoid unnecessary surgery is increasingly important OBJECTIVE: This study aimed to build a predictive model based on clinical and radiological variables for the early identification
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Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis Cancer Biomark. (IF 3.1) Pub Date : 2023-11-20 Julie B. Siegel, Patrick Nasarre, Lillian Hsu, Rupak Mukherjee, Meghan Gormley, Bailey Richardson, Imran Khan, Jordan E. Morningstar, Eleanor Hilliard, John P. O’Bryan, Kristi L. Helke, Laura Spruill, Nathan G. Dolloff, Nancy Klauber-DeMore
Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year survival rates of 9%. We hypothesized that secreted frizzled-related protein 2 (SFRP2) may influence stromal growth in pancreatic cancer, since it increases fibrosis and collagen production in non-neoplastic pathologies. We assessed SFRP2 value as a biomarker and assessed its function in PDAC. SFRP2 gene expression in
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Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response Cancer Biomark. (IF 3.1) Pub Date : 2023-11-15 Lyana Setiawan, Rahajuningsih Setiabudy, Siti Boedina Kresno, Noorwati Sutandyo, Elisna Syahruddin, Frederica Jovianti, Siti Nadliroh, Sofia Mubarika, Rianto Setiabudy, Nurjati C. Siregar
Abstract BACKGROUND: Despite advances in lung cancer treatment, most lung cancers are diagnosed at an advanced stage. Expression of microRNA10b (miR-10b) and fibrinolytic activity, as reflected by soluble urokinase-type plasminogen activator receptor (suPAR) and plasminogen activator inhibitor 1 (PAI-1), are promising biomarker candidates. OBJECTIVE: To assess the expression of miR-10b, and serum levels
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Upregulation of MED7 was associated with progression in hepatocellular carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-11-15 Zheng-Lin Chen, Ying-Yu Ma, Xiao-Zhou Mou, Jun-Gang Zhang
OBJECTIVE: MED subunits have been reported to be associated with various types of tumors, however, the potential role of MED7 in hepatocellular carcinoma (HCC) was still unclear. The aim of the study was to explore the role of MED7 in HCC. METHODS: In this study, MED7 mRNA expression levels betweenHCC and adjacent normal tissues were first analyzed by several public datasets. Then we utilized a tissue
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Comprehensive analysis of thirteen-gene panel with prognosis value in Multiple Myeloma. Cancer Biomark. (IF 3.1) Pub Date : 2023-11-03 Tingting Zheng,Panpan Chen,Yuanlin Xu,Peijun Jia,Yan Li,Yating Li,Jiaming Cao,Wanxin Li,Yazhe Zhen,Ying Zhang,Shijie Zhang,Jiangfeng Du,Jingxin Zhang
BACKGROUND Although there are many treatments for Multiple myeloma (MM), patients with MM still unable to escape the recurrence and aggravation of the disease. OBJECTIVE We constructed a risk model based on genes closely associated with MM prognosis to predict its prognostic value. METHODS Gene function enrichment and signal pathway enrichment analysis, Least Absolute Shrinkage and Selection Operator
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Urinary VOCs as biomarkers of early stage lung tumour development in mice Cancer Biomark. (IF 3.1) Pub Date : 2023-11-03 Flora Gouzerh, Gwenaëlle Vigo, Laurent Dormont, Bruno Buatois, Maxime R. Hervé, Maicol Mancini, Antonio Maraver, Frédéric Thomas, Guila Ganem
Abstract BACKGROUND: Lung cancer is the primary cause of cancer-induced death. In addition to prevention and improved treatment, it has increasingly been established that early detection is critical to successful remission. OBJECTIVE: The aim of this study was to identify volatile organic compounds (VOCs) in urine that could help diagnose mouse lung cancer at an early stage of its development. METHODS:
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Assessing the clinical utility of biomarkers using the intervention probability curve (IPC) Cancer Biomark. (IF 3.1) Pub Date : 2023-10-28 Rafael Paez, Dianna J. Rowe, Stephen A. Deppen, Eric L. Grogan, Alexander Kaizer, Darryl J. Bornhop, Amanda K. Kussrow, Anna E. Barón, Fabien Maldonado, Michael N. Kammer
Abstract BACKGROUND: Assessing the clinical utility of biomarkers is a critical step before clinical implementation. The reclassification of patients across clinically relevant subgroups is considered one of the best methods to estimate clinical utility. However, there are important limitations with this methodology. We recently proposed the intervention probability curve (IPC) which models the likelihood
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Long-chain noncoding RNA LINC01569 upregulates filamin A-interacting protein 1-like to prevent metastasis of triple-negative breast cancer via sponging miR-300 Cancer Biomark. (IF 3.1) Pub Date : 2023-10-28 Xinyu Jiang, Juli Lin, Zhanlin Zhu
Abstract BACKGROUND: Long-chain noncoding RNA (lncRNA), LINC01569, is important for regulating the extracellular matrix, which affects cell migration. However, its involvement in the occurrence and development of triple-negative breast cancer (TNBC) remains unclear. OBJECTIVE: This study is aimed to investigate the role of LINC01569 on TNBC. METHODS: Online database was used for clinical data analysis
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A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets Cancer Biomark. (IF 3.1) Pub Date : 2023-10-27 Amal Alotaibi, Veerendra P. Gadekar, Pranav Swaroop Gundla, Sumana Mandarthi, Subramanyeshwari Ravi, Dhyeya Mallya, Asna Tungekar, B.V. Lavanya, Ashok Kumar Bhagavath, MaryAnne Wong Cordero, Janne Pitkaniemi, Raviraja N. Seetharam, Asmatanzeem Bepari, Prashantha Hebbar
AIM: Esophageal Squamous Cell Carcinoma (ESCC) is a histological subtype of esophageal cancer that begins in the squamous cells in the esophagus. In only 19% of the ESCC-diagnosed patients, a five-year survival rate has been seen. This necessitates the identification of high-confidence biomarkers for early diagnosis, prognosis, and potential therapeutic targets for the mitigation of ESCC. METHOD: We
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Albumin-bilirubin score predicts trastuzumab resistance in HER2-positive breast cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-10-26 Wen-Juan Huang, Jia-Rui Yuan, Lei Zhang, Wen Wang, Shi-Di Miao, Xin Wang, Rui-Tao Wang
BACKGROUND: The albumin-bilirubin (ALBI) score is a novel indicator of liver function. Some studies showed that the ALBI score was a predictive marker for the prognosis and efficacy of drug therapy in malignancies. We aimed to assess the predicted role of ALBI score in the sensitivity to therapy with trastuzumab in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer
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Advances in SEMA3F regulation of clinically high-incidence cancers Cancer Biomark. (IF 3.1) Pub Date : 2023-10-13 Chaofeng Wang, Dezhi Song, Qian Huang, Qian Liu
Cancer has become a leading cause of morbidity and mortality in recent years. Its high prevalence has had a severe impact on society. Researchers have achieved fruitful results in the causative factors, pathogenesis, treatment strategies, and cancer prevention. Semaphorin 3F (SEMA3F), a member of the signaling family, was initially reported in the literature to inhibit the growth, invasion, and metastasis
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CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-10-13 Zhiyong Su, Guanghui Wang, Leilei Li
BACKGROUND: Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are common male diseases whose incidence rates gradually increase with age. They seriously affect men’s physical health and quality of life. This study aimed to identify new biomarkers for the diagnosis of BPH and PCa. METHODS: Two datasets, GSE28204 and GSE134051 (including human PCa and BPH), were downloaded from the GEO database
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Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population Cancer Biomark. (IF 3.1) Pub Date : 2023-10-13 Shikha Tiwari, Ritu Pandey, Vinay Kumar, Saikat Das, Vikas Gupta, Supriya Vishwakarma, Rajeev Nema, Tulasi Sindhuja, Sana Hashmi, Ashok Kumar
BACKGROUND:miRNAs play a crucial role in the genesis of cancer, either as tumor suppressor genes or as oncogenes. Single Nucleotide Polymorphisms (SNPs) in the seed region of microRNAs (miRNAs) can dysregulate their levels in the tissues and thereby affect carcinogenesis. The association of SNP inmiR-146a (rs2910164) with the risk of oral squamous cell carcinoma (OSCC) has not been understood. OBJECTIVE:
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Identification of novel potential genes in testicular germ cell tumors: A transcriptome analysis Cancer Biomark. (IF 3.1) Pub Date : 2023-10-13 Shaokai Zheng, Ting Li, Lianglin Qiu
OBJECTIVE: Testicular germ cell tumors (TGCTs), containing pure seminoma and non-seminoma, occupy the most majority of testicular cancers in adolescents and young men, which has increased dramatically in recent decades. Therefore, it is important to find crucial genes for improving diagnosis and prognosis in TGCTs. However, the diagnostic and prognostic markers of TGCTs are limited. METHODS: In this
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TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-09-05 Tabitha R. Hudock, Vayda R. Barker, Brandon J. Manley, Andrea Chobrutskiy, Boris I. Chobrutskiy, Michael J. Diaz, Joanna J. Song, George Blanck
BACKGROUND: Immunogenomics approaches to the characterization of renal cell carcinoma (RCC) have helped to better our understanding of the features of RCC immune dysfunction. However, much is still unknown with regard to specific immune interactions and their impact in the tumor microenvironment. OBJECTIVE: This study applied chemical complementarity scoring for the TRB complementarity determining
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Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma Cancer Biomark. (IF 3.1) Pub Date : 2023-09-06 Ismail Beypınar, Yıldız Sözel, Arif Hakan Önder
BACKGROUND: The response of Renal Cell Cancer (RCC) to tyrosine kinase inhibitors (TKI) has been well established. Although these stratifications have been established for TKI response and prognosis, these parameters have recently been used to predict immunotherapy response in RCC. We aimed to usea combination of clinical parameters of International Metastatic Renal Cell Carcinoma Database Consortium
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LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis Cancer Biomark. (IF 3.1) Pub Date : 2023-09-05 Zhibin Lu, Zhichao Xiao, Qi Wang, Chunfeng Pan, Yang Xia, Weibing Wu, Liang Chen
BACKGROUND: Non-small lung cancer ranks first in the cancer-related death of all malignant tumors. Exploring novel biological targets is of great significance for diagnosis and therapy of NSCLC. OBJECTIVE: In this study, we aimed to explore the effect of LINC00668 on the biological functions of NSCLC cells and the underlying mechanism. METHODS: RT-qPCR assays and western blot assays were utilized to
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Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-09-05 Jiting Sun, Jun Shu, Duo Shi, Wen Liu, Yan Zhang, Bing Luo
BACKGROUND: Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a common malignant tumor associated with EBV infection. Insulin-like growth factor 2 (IGF2) is an imprinted gene and a key protein that regulates growth, especially during normal fetal development. Loss of imprinting (LOI),is a common epigenetic anomaly in a variety of human cancers. However, the promoter methylation, imprinting
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Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach Cancer Biomark. (IF 3.1) Pub Date : 2023-09-02 Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Somchai Chutipongtanate, Sutatip Pongcharoen
BACKGROUND: Lung adenocarcinoma (LUAD) is a major histological subtype of lung cancer with a high mortality rate worldwide. Heat shock protein family D member 1 (HSPD1, also known as HSP60) is reported to be increased in tumor tissues of lung cancer patients compared with healthy control tissues. OBJECTIVE: We aimed to investigate the roles of HSPD1 in prognosis, carcinogenesis, and immune infiltration
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Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p Cancer Biomark. (IF 3.1) Pub Date : 2023-09-02 Peina He, Zhi Liu, Jinxu Qi, Junrao Shan, Jianyun Sheng
Abstract BACKGROUND: LINC00885 is a novel oncogenic long noncoding RNA (LncRNA) which is upregulated in various types of cancer, but its function in triple-negative breast cancer (TNBC) remains unknown. OBJECTIVE: This study aimed to determine the role of LINC00885 on TNBC development. METHODS: Clinical interrelation and survival analysis were determined using online database. The CCK-8 and Transwell
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Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing Cancer Biomark. (IF 3.1) Pub Date : 2023-09-02 Varsha Singh, Amit Katiyar, Prabhat Malik, Sunil Kumar, Anant Mohan, Harpreet Singh, Deepali Jain
OBJECTIVES: Significant progress has been made in the treatment of patients with pulmonary adenocarcinoma (ADCA) based on molecular profiling. However, no such molecular target exists for squamous cell carcinoma (SQCC). An exome sequence may provide new markers for personalized medicine for lung cancer patients of all subtypes. The current study aims to discover new genetic markers that can be used
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The long non-coding RNA transcript, LOC100130460 ( CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues Cancer Biomark. (IF 3.1) Pub Date : 2023-08-16 Aldo Donizetti, Massimo Venditti, Davide Arcainolo, Vincenza Aliperti, Anna Maria Carrese, Marco De Sio, Sergio Minucci, Michele Caraglia, Francesco Aniello
BACKGROUND: Testis-specific genes encoding for long non-coding RNA (lncRNA) have been detected in several cancers; many produce proteins with restricted or aberrant expression patterns in normal or cancer tissues. OBJECTIVE: To characterize new lncRNA involved in normal and/or pathological differentiation of testicular cells. METHODS: Using bioinformatics analysis, we found that lncRNA LOC100130460
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Prediction for recurrent non-muscle invasive bladder cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-08-15 Keqiang Li, Aravind Raveendran, Guoqing Xie, Yu Zhang, Haofan Wu, Zhenlin Huang, Zhankui Jia, Jinjian Yang
Non-muscle invasive bladder cancer (NMIBC) has a high recurrence rate, which places a significant burden on both patients and the healthcare system. Hence, it holds significant importance to predict the recurrence risk following treatment for individuals diagnosed with non-muscle invasive bladder cancer (NMIBC). As new generation technologies continue to emerge, an increasing number of recurrence risk
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lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p Cancer Biomark. (IF 3.1) Pub Date : 2023-08-12 Bo Pang, Yanfang Gan, Jing Wang, Shifang Qu
BACKGROUND: Numerous evidence have suggested the vital role of lncRNAs in human tumorigenesis. And lncRNA APAP1-AS1 has been proved to act as an oncogene. OBJECTIVE: Nevertheless, the molecular process underlying ARAP1-AS1 for the lymphoma progression has not been well studied. METHODS: RT-qPCR wasused to ascertain the miR-6867-5p and ARAP1-AS1 in lymphoma cells and tissues. The localization of ARAP1-AS1
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LncRNA ARAP1-AS1 contributes to lung adenocarcinoma development by targeting miR-8068 to upregulate CEACAM5 Cancer Biomark. (IF 3.1) Pub Date : 2023-07-27 Zhiqiang Wu, Xiaofei Zeng, Hong Wang, Xianbo Wang
BACKGROUND: It has been discovered that lncRNA ARAP1-AS1 is upregulated and operates as a tumor promoter in many cancers. However, its pattern of expression and potential mechanism in lung adenocarcinoma (LUAD) is still unknown. METHODS: The levels of lncRNA ARAP1-AS1, miR-8068, and CEACAM5 expressions in LUAD cell lines and tissues were assessed by conducting western blot and RT-qPCR analyses. MiR-8068’s
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Granzymes expression patterns predict immunotherapy response and identify the heterogeneity of CD8+ T cell subsets Cancer Biomark. (IF 3.1) Pub Date : 2023-07-27 Jing Li, Huibo Zhang, Jie Wu, Lan Li, Bin Xu, Qibin Song
BACKGROUND: Recent studies illustrated the effects of granzymes (GZMs) gene alterations on immunotherapy response of cancer patients. Thus, we aimed to systematically analyze the expression and prognostic value of GZMs for immunotherapy in different cancers, and identified heterogeneity of the GZMsexpression-based CD8+ T cell subsets. METHODS: First, we analyzed GZMs expression and prognostic value
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Machine learning methods revealed the roles of immune-metabolism related genes in immune infiltration, stemness, and prognosis of neuroblastoma Cancer Biomark. (IF 3.1) Pub Date : 2023-07-25 Jianhua Mu, Jianan Gong, Peng Lin, Mengzhen Zhang, Kai Wu
BACKGROUND: Immunometabolism plays an important role in neuroblastoma (NB). However, the mechanism of immune-and metabolism-related genes (IMRGs) in NB remains unclear. This study aimed to explore the effects of IMRGs on the prognosis, immune infiltration and stemness of patients with NB using machine learning methods. METHODS: R software (v4.2.1) was used to identify the differentially expressed IMRGs
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Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-07-24 Yuan Fang, Weiqiang Tang, Dan Zhao, Xiaoli Zhang, Na Li, Yang Yang, Li Jin, Zhitao Li, Benkai Wei, Yinglei Miao, Zhong Zeng, Hanfei Huang
BACKGROUND: Lymphoid-specific helicase (HELLS), a SNF2-like chromatin-remodeling enzyme, plays a key role in tumor progression via its DNA methylation function. However, the effects of HELLS on immune infiltration and prognosis in liver hepatocellular carcinoma (LIHC) remain uncertain. METHODS: TheTumor Immune Estimation Resource (TIMER) database was employed to explore the pan-cancer mRNA expression
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Salidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway Cancer Biomark. (IF 3.1) Pub Date : 2023-07-23 Ru-Han Liu, Teng-Fei Ma, Qin Yang, Wen-Chang Xiao, Lu Yin, Miao Yin, Jin-Song Zhang, Chi-Hua Wang
BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies in men. PCa is difficult to detect in its early stages, and most patients are diagnosed in the middle to late stages. At present, drug therapy for advanced PCa is still insufficient. Some patients develop drug resistance in the later stage of therapy, which leads to tumor recurrence, metastasis and even treatment failure. Therefore
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Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Xiuli Wang, Baoshan Zhao, Dan Ren, Xiaolei Hu, Juanjuan Qiao, Dongmei Zhang, Yanzhi Zhang, Yu Pan, Yuhua Fan, Lili Liu, Xiaoxue Wang, Huanhuan Ma, Xueling Jia, Sihang Song, Chong Zhao, Jingbo Liu, Lin Wang
BACKGROUD: Previous in vitro studies have indicated that pyrimidinergic receptor P2Y6 (P2RY6, P2Y6 receptor) may function as a cancer-promoting factor in lung adenocarcinoma (LUAD). However, the prognostic significance of P2RY6 expression in LUAD has not been investigated. OBJECTIVE: This study aimed to assess the impact of P2RY6 expression on the survival of patients with LUAD. METHODS: First, we
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Impact of the peripheral blood inflammatory indices and modified nomogram-revised risk index on survival of Extranodal Nasal-Type Natural Killer/T-Cell lymphoma Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Qing Hou, He Li, Yu Liang, Ningning Yao, Xin Cao, Jianting Liu, Bochen Sun, Peixin Feng, Wenjuan Zhang, Jianzhong Cao
Abstract BACKGROUND: At present, peripheral blood markers are easily accessible information and clinically valuable prognostic indicators in extranodal nasal-type natural killer/T-cell lymphoma (ENKTCL). Nevertheless, the role of its comprehensive score in ENKTCL remains to be determined. OBJECTIVE: Therefore, this study aimed to investigate the prognostic effect of the peripheral inflammation score
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Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Adam Gorczyński, Kevin Miszewski, Yann Gager, Sonja Koch, Jane Pötschke, Dimitar Ugrinovski, Jörg Gabert, Agata Pospieszyńska, Dariusz Wydra, Renata Duchnowska, Bartosz Szymanowski, Szczepan Cierniak, Irene Kruecken, Karsten Neumann, Katarina Mirkov, Wojciech Biernat, Piotr Czapiewski
BACKGROUND: ALK receptor tyrosine kinase (ALK) aberrations have an established role in pathogenesis of many neoplasms, but their clinical significance in high grade serous ovarian carcinoma (HGSOC) is unclear. OBJECTIVE: To analyse the frequency of ALK overexpression, molecular abnormalities of ALK, and their impact on the progression-free survival (PFS) and overall survival (OS) in HGSOC. METHODS:
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Analysis of clinical significance and molecular characteristics of methionine metabolism and macrophage-related patterns in hepatocellular carcinoma based on machine learning Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Diguang Wen, Shuling Wang, Jiajian Yu, Ting Yu, Zuojin Liu, Yue Li
Abstract BACKGROUND: Increasing evidence has indicated that abnormal methionine metabolic activity and tumour-associated macrophage infiltration are correlated with hepatocarcinogenesis. However, the relationship between methionine metabolic activity and tumour-associated macrophage infiltration is unclear in hepatocellular carcinoma, and it contributes to the occurrence and clinical outcome of hepatocellular
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A single targeted gamma-ray irradiation induced an acute modulation of immune cells and related cytokines in EMT6 mouse-bearing tumour model Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Nurhaslina Hasan, Narimah Abdul Hamid Hasani, Effat Omar, Fatihah Ronny Sham, Syed Baharom Syed Ahmad Fuad, Muhammad Khalis Abdul Karim, Mohammad Johari Ibahim
BACKGROUND: A complicated interplay between radiation doses, tumour microenvironment (TME), and host immune system is linked to the active participation of immune response. OBJECTIVE: The effects of single targeted 2 Gy and 8 Gy gamma-ray irradiations on the immune cell population (lymphocytes, B-cells, T-cells, neutrophils, eosinophils, and macrophages) in EMT6 mouse-bearing tumour models was investigated
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Looking for biomarkers in interferon response pathway to predict response to oncolytic HSV-1 in breast cancer: An ex vivo study Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Zahra Nejatipour, Ladan Teimoori-Toolabi, Ramin Sarrami Forooshani, Mahdieh Shokrollahi Barough, Mohammad Farahmand, Alireza Biglari, Kayhan Azadmanesh
Breast cancer is the most common malignancy in women worldwide. Administration of oncolytic viruses is one of the novel promising cancer therapy approaches. Replication of these viruses is usually limited to cancer cells that have interferon (IFN) signaling defects. However, Interferon signaling isnot completely impaired in all cancer cells which may limit the benefits of virotherapy. Identification
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The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Jun Sun, Hui Cao, Tingting Wen, Zi Xu, Xian Zhang, Hong Zhu, Jianjun Wang
BACKGROUND: Cell surface molecules play important roles in cell signal transduction pathways during microbial infection. OBJECTIVE: In this study, the expression and the functions of CD59 was investigated in H. pylori infected gastric cancer (GC). METHODS AND RESULTS: The differential expression ofCD59 and the influence of H. pylori on the expression of CD59 were analyzed via bioinformatics through
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Comprehensive analysis and establishment of a prognostic model based on non-genetic predictors in multiple myeloma Cancer Biomark. (IF 3.1) Pub Date : 2023-07-20 Weiguo Lu, Shumin Xu, Lu Lu, Man Luo, Mingfeng Xiao
Abstract BACKGROUND: Multiple myeloma (MM) is a systemic hematological malignancy usually incurable. The value of some important prognostic factors may gradually decrease. OBJECTIVE: We aimed to explore the non-genetic indexes, prognostic models, and significance of clinical staging systems of MM. METHODS: A retrospective analysis was conducted on clinical data from 110 patients with MM who first visit