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Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations J. Oncol. (IF 4.501) Pub Date : 2024-3-18 Hiromitsu Nakahashi, Tatsuya Oda, Osamu Shimomura, Yoshimasa Akashi, Kazuhiro Takahashi, Yoshihiro Miyazaki, Tomoaki Furuta, Yukihito Kuroda, Pakavarin Louphrasitthiphol, Bryan J. Mathis, Hiroaki Tateno
Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive
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Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc J. Oncol. (IF 4.501) Pub Date : 2024-1-12 Shital K. Barman, Monokesh K. Sen, David A. Mahns, Ming J. Wu, Chandra S. Malladi
Zinc dyshomeostasis is manifested in breast and prostate cancer cells. This study attempted to uncover the molecular details prodded by the change of extracellular zinc by employing a panel of normal and cancerous breast and prostate cell lines coupled with the top-down proteomics with two-dimensional gel electrophoresis followed by liquid chromatography-tandem mass spectrometry. The protein samples
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ARV-825 Showed Antitumor Activity against BRD4-NUT Fusion Protein by Targeting the BRD4 J. Oncol. (IF 4.501) Pub Date : 2023-12-14 Liu Yang, Yue Jing, Xia Xia, Xiushan Yin
Objective. The bromodomain-containing 4 (BRD4) is a member of the bromodomain and extra terminal domain (BET) family, which is an important epigenetic reader. It is currently a promising oncology target. In some tumors, BET bromodomain inhibitors have demonstrated promising results. Proteolysis-targeting methods (PROTAC), which rapidly and effectively degrade BRD4, have displayed considerable potential
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A Natural Organic Compound “Decursin” Has Both Antitumor and Renal Protective Effects: Treatment for Osteosarcoma J. Oncol. (IF 4.501) Pub Date : 2023-12-14 Daichi Hayashi, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Naoki Mizoshiri, Yuki Mori, Seiji Shimomura, Osam Mazda, Kenji Takahashi
Osteosarcoma is a rare malignant tumor that commonly occurs in children. Anticancer drugs, for example, cisplatin, aid in postsurgery recovery but induce side effects such as renal damage, affecting the life prognosis of patients. Decursin which is one of the bioactive components has been reported for its anti-inflammatory, antioxidant, and antitumor effects, but the effect on osteosarcoma is unexplained
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Retracted: IL2RB Is a Prognostic Biomarker Associated with Immune Infiltrates in Pan-Cancer. J. Oncol. (IF 4.501) Pub Date : 2023-11-01 Journal Of Oncology
[This retracts the article DOI: 10.1155/2022/2043880.].
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Corrigendum to "Function of N6-Methyladenosine Modification in Tumors". J. Oncol. (IF 4.501) Pub Date : 2023-10-10 Nan Zhang,Yuxin Zuo,Yu Peng,Lielian Zuo
[This corrects the article DOI: 10.1155/2021/6461552.].
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Histopathologic Patterns of Ovarian Tumors in Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia J. Oncol. (IF 4.501) Pub Date : 2023-9-14 Tibebu Amare Abena, Fekade Yerakly, Tesfalem Korga
Objective. In Ethiopia, there is no national-level cancer registry except capital Addis Ababa, and little research was performed on ovarian tumors. This study is aimed at assessing different histopathologic patterns of ovarian tumors and their distribution based on age, biological behavior, and gross findings at a tertiary-level hospital in Ethiopia. Methods. In this study, 187 biopsy-confirmed ovarian
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Retracted: Application of Free Skin Flap Transplantation in Skin Malignant Tumor Resection. J. Oncol. (IF 4.501) Pub Date : 2023-08-02 Journal Of Oncology
[This retracts the article DOI: 10.1155/2022/7510330.].
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Retracted: Meta-Study of the Clinical Effect of Conservative Treatment in Uterine Fibroids. J. Oncol. (IF 4.501) Pub Date : 2023-08-02 Journal Of Oncology
[This retracts the article DOI: 10.1155/2022/6114287.].
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miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells J. Oncol. (IF 4.501) Pub Date : 2023-7-28 Bo-Shih Huang, Chih-Ta Chen, Chao-Chi Yeh, Ting-Yu Fan, Fang-Yun Chen, Jyh-Ming Liou, Chia-Tung Shun, Ming-Shiang Wu, Lu-Ping Chow
Helicobacter pylori (H. pylori) infection affects cell survival pathways, including apoptosis and proliferation in host cells, and disruption of this balance is the key event in the development of H. pylori-induced gastric cancer (HPGC). H. pylori infection induces alterations in microRNAs expression that may be involved in GC development. Bioinformatic analysis showed that microRNA-21 (miR-21) is
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Retracted: Red Blood Cell Membrane-Camouflaged Gold Nanoparticles for Treatment of Melanoma. J. Oncol. (IF 4.501) Pub Date : 2023-07-12 Journal Of Oncology
[This retracts the article DOI: 10.1155/2022/3514984.].
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Retracted: SFRP2 is a Novel Diagnostic Biomarker and Suppresses the Proliferation of Pituitary Adenoma. J. Oncol. (IF 4.501) Pub Date : 2023-07-12 Journal Of Oncology
[This retracts the article DOI: 10.1155/2022/4272525.].
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Fibroblast Growth Factor 11 Enables Tumor Cell Immune Escape by Promoting T Cell Exhaustion and Predicts Poor Prognosis in Patients with Lung Adenocarcinoma J. Oncol. (IF 4.501) Pub Date : 2023-5-19 Baoqian Zhai, Jiacheng Wu, Tao Li
Fibroblast growth factor 11 (FGF11) accelerates tumor proliferation in a variety of cancer types. This study aimed to examine the link between FGF11 and the prognosis of lung adenocarcinoma. FGF11 was searched in the Tumor Cancer Genome Atlas (TCGA) and ImmProt databases. The link between FGF11 and lung cancer clinical data was investigated using TCGA and Kaplan–Meier (KM)-plotter databases, and we
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Increased Expression of SRSF1 Predicts Poor Prognosis in Multiple Myeloma J. Oncol. (IF 4.501) Pub Date : 2023-5-10 Jiawei Zhang, Zanzan Wang, Kailai Wang, Dijia Xin, Luyao Wang, Yili Fan, Yang Xu
Background. Multiple myeloma (MM) is a clonal plasma cell disorder which still lacks sufficient prognostic factors. The serine/arginine-rich splicing factor (SRSF) family serves as an important splicing regulator in organ development. Among all members, SRSF1 plays an important role in cell proliferation and renewal. However, the role of SRSF1 in MM is still unknown. Methods. SRSF1 was selected from
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HKDC1 Silencing Inhibits Proliferation and Glycolysis of Gastric Cancer Cells J. Oncol. (IF 4.501) Pub Date : 2023-4-28 Chen Yu, Ting-ting Bao, Li Jin, Jian-wei Lu, Ji-feng Feng
Gastric cancer (GC) is the third most lethal and fifth most common cancer in the world. In a variety of cancers, the hexokinase domain component 1 (HKDC1) is carcinogenic. This study was to investigate into how HKDC1 contributes to the development and progression of GC. Three different datasets (GSE103236, GSE13861, and GSE55696) were extracted from the Gene Expression Omnibus (GEO) database and then
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Insights into the Oncogenic, Prognostic, and Immunological Role of BRIP1 in Pan-Cancer: A Comprehensive Data-Mining-Based Study J. Oncol. (IF 4.501) Pub Date : 2023-4-28 Yongru Liu, Xi Wu, Yunlu Feng, Qingwei Jiang, Shengyu Zhang, Qiang Wang, Aiming Yang
Background. BRCA1 interacting helicase 1 (BRIP1), an ATP-dependent DNA helicase which belongs to an Iron-Sulfur (Fe-S) helicase cluster family with a DEAH domain, plays a key role in DNA damage and repair, Fanconi anemia, and development of several cancers including breast and ovarian cancer. However, its role in pan-cancer remains largely unknown. Methods. BRIP1 expression data of tumor and normal
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SH3BGRL Suppresses Liver Tumor Progression through Enhanced ATG5-Dependent Autophagy J. Oncol. (IF 4.501) Pub Date : 2023-4-24 Abdulmomen Ali Mohammed Saleh, Farhan Haider, Haimei Lv, Bin Liu, Jing Xiao, Mingming Zhang, Yuzhen Zheng, Shulan Yang, Haihe Wang
SH3BGRL, an adaptor protein, is upregulated in breast cancers and indicates its tumorigenic role. But the function of SH3BGRL in other types of cancers is largely unknown. Here, we modulate SH3BGRL expression level in two liver cancer cells and conduct both in vitro and in vivo analyses of SH3BGRL in cell proliferation and tumorigenesis. Results demonstrate that SH3BGRL notably inhibits cell proliferation
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Expression of Th1/2/17 Cytokines in CML with or without Pulmonary Bacterial and Fungal Coinfection J. Oncol. (IF 4.501) Pub Date : 2023-4-18 Xin Guan, Chaoran Zhang, Peng Hu, Zefeng Yang, Jinping Zhang, Yunlian Zou, Yan Wen, Huiyuan Li, Tonghua Yang, Renbin Zhao, Zengzheng Li
Background. Tyrosine kinase inhibitors (TKIs) are the standard therapy for patients with chronic myeloid leukemia (CML). While their use greatly increases patient survival rates and can lead to normal life expectancy, bacterial infections in the lungs continue to play a significant role in determining patient outcomes. Methods. In this study, the medical records of 272 CML and 53 healthy adults were
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Integrated Analyses of the Expression and Prognostic Value of EPHB6 in Cervical Cancer and Its Correlation with Immune Infiltrates J. Oncol. (IF 4.501) Pub Date : 2023-4-17 Siyang Xiang, Mei Wei, Limei Zhao, Anping Lin, Zhengai Xiong
Among women, cervical cancer (CC) ranks as the third most frequent form of carcinoma and the fourth greatest cancer-related cause of deaths. There is increasing evidence that points to the dysregulation of EPH receptor B6 (EPHB6) in various cancers. On the other hand, neither the expression nor the function of EPHB6 in CC has been researched. In the first part of this investigation, we analyzed the
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Early Experience of TACE Combined with Atezolizumab plus Bevacizumab for Patients with Intermediate-Stage Hepatocellular Carcinoma beyond Up-to-Seven Criteria: A Multicenter, Single-Arm Study J. Oncol. (IF 4.501) Pub Date : 2023-4-15 Kang Wang, Hongfei Zhu, Hongming Yu, Yuqiang Cheng, Yanjun Xiang, Zhangjun Cheng, Yang Li, Tao Li, Dongxu Wang, Zhenyu Zhu, Shuqun Cheng
Aim. Locoregional treatment, such as TACE, in combination with immunotherapy may elicit a synergistic anticancer effect. However, TACE combined with atezolizumab plus bevacizumab (atezo/bev) has not been investigated for patients with intermediate stage (BCLC B) HCC beyond the up-to-seven criteria. This study aims to evaluate the efficacy and safety of this treatment strategy in intermediate-stage
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Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching J. Oncol. (IF 4.501) Pub Date : 2023-4-8 Zhenwei Li, Bo Xu, Jingjing Cai, Zhengang Zha
Background. The study aims to identify whether osteosarcoma patients of children and young adults will benefit from a survival profit from the choice of the operation method. Methods. The National Cancer Institute SEER database from 2000 to 2018 was selected for a retrospective analysis of 1630 children and young adults with a primary diagnosis of osteosarcoma, 1222 who underwent limb-preserving surgery
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A 20-Gene Signature Predicting Survival in Patients with Clear Cell Renal Cell Carcinoma Based on Basement Membrane J. Oncol. (IF 4.501) Pub Date : 2023-4-8 Zhenjie Yin, Yu Zhao, Weiwen Zhou, Chengcheng You, Yuanyuan Bai, Bingyong You, Dongming Lu, Shangfan Liao, Luoping Zheng, Yingming Sun, Yongyang Wu
Objectives. The most common subtype of renal cell carcinoma, clear cell renal cell carcinoma (ccRCC), has a high heterogeneity and aggressive nature. The basement membrane (BM) is known to play a vital role in tumor metastasis. BM-related genes remain untested in ccRCC, however, in terms of their prognostic significance. Methods. BM-related genes were gleaned from the most recent cutting-edge research
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A Novel 7-Methylguanosine (m7G)-Related Gene Signature for Overall Survival Prediction in Patient with Clear Cell Renal Cell Carcinoma J. Oncol. (IF 4.501) Pub Date : 2023-4-8 Yongxin Fu, Jiawu Wang, Zhiya Hu, Yang Gou, Yisen Li, Qing Jiang
Clear cell renal cell carcinoma (ccRCC) is the most common pathology type of renal cancer that has an abysmal prognosis. Although a crucial role for 7-methylguanosine modification in cancer cell development has been reported, its role in ccRCC remains uncertain. This study was conducted to determine the efficacy of predictive biomarkers based on m7G-related genes in ccRCC. Firstly, we extracted clinical
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The Relationship between PBLS and Osteosarcoma Distribution in Different Subgroups and the Survival and Prognosis of Osteosarcoma J. Oncol. (IF 4.501) Pub Date : 2023-4-7 Peng Luo, Peng Zhou
Objective. To analyze the differences in the distribution of lymphocytes (PBLS) in different subgroups of osteosarcoma (OS) and the predictive value of related parameters on the survival prognosis of OS. Methods. For retrospective analysis, 80 patients with malignant OS diagnosed and treated in our hospital from June 2016 to June 2017 were selected as the observation group, and 80 patients with benign
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Hypoxia-Related lncRNA Prognostic Model of Ovarian Cancer Based on Big Data Analysis J. Oncol. (IF 4.501) Pub Date : 2023-4-7 Yu Zhang, Jing Zhang, Fei Wang, Le Wang
Background. Hypoxia is regarded as a key factor in promoting the occurrence and development of ovarian cancer. In ovarian cancer, hypoxia promotes cell proliferation, epithelial to mesenchymal transformation, invasion, and metastasis. Long non-coding RNAs (lncRNAs) are extensively involved in the regulation of many cellular mechanisms, i.e., gene expression, cell growth, and cell cycle. Materials and
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CD86 Is Associated with Immune Infiltration and Immunotherapy Signatures in AML and Promotes Its Progression J. Oncol. (IF 4.501) Pub Date : 2023-4-7 Qianqian Zhang, Ruixue Ma, Huimin Chen, Wentong Guo, Zhenyu Li, Kailin Xu, Wei Chen
Background. Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and survival. CD86 binds to two ligands on the surface of T cells: the antigen CD28 and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). By binding to CD28, CD86—together with CD80—promotes the participation
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Variations in Emergency Service Utilization among Cancer Survivors: Results from the Pan-Canadian Experiences of Cancer Patients in Transition Study Survey J. Oncol. (IF 4.501) Pub Date : 2023-3-16 Megan Delisle, Ying Wang, Margaret I. Fitch, Kalki Nagaratnam, Amirrtha Srikanthan
Purpose. The objective of this study was to examine variations in emergency service utilization (ESU) among cancer survivors during the first year after completing primary cancer treatment. Methods. In 2016, the Canadian Partnership Against Cancer collected survey responses from cancer survivors across Canada about self-reported ESU after completing primary cancer treatment. We included survey respondents
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Fatigue and Its Contributing Factors in Chinese Patients with Primary Pituitary Adenomas J. Oncol. (IF 4.501) Pub Date : 2023-3-15 Xiaomei Zhang, Yanqing Li, Dandan Zhang, Yueping Zhong, Tian Li
Background. Pituitary adenomas (PAs) refers to a group of benign tumors that develop in the pituitary gland and are often characterized by fatigue. However, fatigue has not been documented in any Chinese research involving people with primary PA. The study sought to examine the prevalence, predictors, and correlation of fatigue with the quality of life (QoL) among PA patients in China. Methods. In
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The Progress in Reconstruction of Mandibular Defect Caused by Osteoradionecrosis J. Oncol. (IF 4.501) Pub Date : 2023-3-15 Nan Huang, Peihan Wang, Ping Gong, Bo Huang
Osteoradionecrosis (ORN) is described as a disease with exposed, nonviable bone that fails to heal spontaneously or by means of conservative treatment after radiotherapy in at least 3 months. Though traditional theories in the early stage including hypoxic-hypocellular-hypovascular and fibro-atrophic in addition to new findings such as ferroptosis were put forward to explain the mechanisms of the osteoradionecrosis
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Construction of a Prognostic Model for Predicting Colorectal Cancer Prognosis and Response to Immunotherapy Based on Cuproptosis-Associated lncRNAs J. Oncol. (IF 4.501) Pub Date : 2023-3-15 Yi Yang, Xiaoli Wang, Jin Lu, Zhiyong Dong, Ruixiang Hu, Wenhui Chen, Songhao Hu, Guanhua Lu, Biao Huang, Shiliang Dong, Lu Wang, Cunchuan Wang
Colorectal cancer (CRC) is a common and highly lethal gastrointestinal malignancy. Immunotherapy has shown positive efficacy in the treatment of CRC; however, only a minority of patients benefit from immunotherapy. The aim of this study is to construct a cuproptosis-related lncRNA (CRLs) risk score model to predict the prognosis and immune infiltration of CRC patients. Firstly, we synthetically analyzed
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LncRNA PTOV1-AS2 Promotes Colon Cancer Progression through the miR-145-5p/FSCN1 Axis J. Oncol. (IF 4.501) Pub Date : 2023-3-14 Zhen Zhang, Honglei Wu, Zhaosheng Chen, Guangchun Li, Jianqiang Guo
Objective. The long noncoding RNA (lncRNA) gene PTOV1-AS2 is a potentially oncogenic lncRNA gene. However, its role and regulatory mechanism in the occurrence and development of colon cancer are still unclear. In this study, the lncRNA PTOV1-AS2 was used as a starting point to investigate the role of competing endogenous RNA (ceRNA) regulatory mechanisms in colon cancer. Methods. The expression of
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Prediction of the Prognosis of Clear Cell Renal Cell Carcinoma by Cuproptosis-Related lncRNA Signals Based on Machine Learning and Construction of ceRNA Network J. Oncol. (IF 4.501) Pub Date : 2023-3-13 Zhiliang Xiao, Menglei Zhang, Zhenduo Shi, Guanghui Zang, Qing Liang, Lin Hao, Yang Dong, Kun Pang, Yabin Wang, Conghui Han
Background. Clear cell renal cell carcinoma’s (ccRCC) occurrence and development are strongly linked to the metabolic reprogramming of tumors, and thus far, neither its prognosis nor treatment has achieved satisfying clinical outcomes. Methods. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, respectively, provided us with information on the RNA expression of ccRCC patients
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The Formation of NETs and Their Mechanism of Promoting Tumor Metastasis J. Oncol. (IF 4.501) Pub Date : 2023-3-11 Jian Li, Jing Chen, Jing Sun, Kaichun Li
Neutrophil extracellular traps (NETs) are network structures comprised of decondensed DNA strands coated with granule proteins. There have been three types of NETs recorded. NETs have been discovered concerning the progression of some malignancies, including gastric cancer, breast cancer, ovarian cancer, hepatocellular carcinoma, colorectal cancer, glioblastoma, diffuse large B cell lymphoma (DLBCL)
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TNFSF15 and MIA Variant Associated with Immunotherapy and Prognostic Evaluation in Esophageal Cancer J. Oncol. (IF 4.501) Pub Date : 2023-3-10 Jun You, Jiaojiao Bian, Jian Chen, Tianqin Xia, Ailu Deng, Ming Zhang, YiChen Liao, Huling Wen, Zhengmin Xu
Background. Esophageal cancer (ESCA) is a common gastrointestinal tumor, and China is one of the regions with a high incidence. Tumor immune-related cells play important roles in the tumorigenesis and development of ESCA. However, the role of tumor immune-related genes in the development of ESCA has not been established. Methods. In this study, weighted gene coexpression network analysis (WGCNA) was
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Preoperative Cervical Lymph Node Metastasis Prediction in Papillary Thyroid Carcinoma: A Noninvasive Clinical Multimodal Radiomics (CMR) Nomogram Analysis J. Oncol. (IF 4.501) Pub Date : 2023-3-9 Wenjuan Hu, Yuzhong Zhuang, Lang Tang, Hongyan Chen, Hao Wang, Ran Wei, Lanyun Wang, Yi Ding, Xiaoli Xie, Yaqiong Ge, Pu-Yeh Wu, Bin Song
This study aimed to evaluate the feasibility of applying a clinical multimodal radiomics nomogram based on ultrasonography (US) and multiparametric magnetic resonance imaging (MRI) for the prediction of cervical lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) preoperatively. We performed retrospective evaluations of 133 patients with pathologically confirmed PTC, who were assigned
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Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes J. Oncol. (IF 4.501) Pub Date : 2023-3-8 Yanjun Zhou, Jiahao Zhu, Mengxuan Gu, Ke Gu
Increasing evidence suggests that diverse activation patterns of metabolic signalling pathways may lead to molecular diversity of cervical cancer (CC). But rare research focuses on the alternation of fatty acid metabolism (FAM) in CC. Therefore, we constructed and compared models based on the expression of FAM-related genes from the Cancer Genome Atlas by different machine learning algorithms. The
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Identification and Validation of a m5C RNA Modification-Related Gene Signature for Predicting Prognosis and Immunotherapeutic Efficiency of Gastric Cancer J. Oncol. (IF 4.501) Pub Date : 2023-3-8 Li Song, Shouguo Wang, Qiankun Li, Yao Lu, Rungong Yang, Xianqi Feng
Background. 5-methylcytosine (m5C) is a major site of RNA methylation modification, and its abnormal modification is associated with the development of gastric cancer (GC). This study aimed to explore the value of m5C-related genes on the prognosis of GC patients through bioinformatics. Methods. First, m5C-related genes were obtained by nonnegative matrix factorization (NMF) analysis and differentially
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Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma J. Oncol. (IF 4.501) Pub Date : 2023-3-8 Natalia Miroschnikov, Oliver Dräger, Dario Van Meenen, Klaus Metz, Bettina Budeus, Nicole Dünker, Maike Anna Busch
The chemotherapy of retinoblastoma (RB), a malignant ocular childhood disease, is often limited by the development of resistance against commonly used drugs. We identified inositol polyphosphate 4-phosphatase type II (INPP4B) as a differentially regulated gene in etoposide-resistant RB cell lines, potentially involved in the development of RB resistances. INPP4B is controversially discussed as a tumor
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Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer J. Oncol. (IF 4.501) Pub Date : 2023-3-7 Pingfei Tang, Yueming Wu, Chaojun Zhu, Qingyuan Li, Side Liu
Background. Hypoxia contributes to tumor progression and confers drug resistance. We attempted to microdissect the hypoxia landscape in colon cancer (CC) and explore its correlation with immunotherapy response. Materials and Methods. The hypoxia landscape in CC patients was microdissected through unsupervised clustering. The “xCell” algorithms were applied to decipher the tumor immune infiltration
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Single-Cell and Transcriptome-Based Immune Cell-Related Prognostic Model in Clear Cell Renal Cell Carcinoma J. Oncol. (IF 4.501) Pub Date : 2023-3-7 Guanlin Wu, Weiming Guo, Shuai Zhu, Gang Fan
Traditional studies mostly focus on the role of single gene in regulating clear cell renal cell carcinoma (ccRCC), while it ignores the impact of tumour heterogeneity on disease progression. The purpose of this study is to construct a prognostic risk model for ccRCC by analysing the differential marker genes related to immune cells in the single-cell database to provide help in clinical diagnosis and
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A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways J. Oncol. (IF 4.501) Pub Date : 2023-3-7 Shao-Feng Duan, Meng-Meng Zhang, Qian Dong, Bo Yang, Wei Liu, Xin Zhang, Hai-Lan Yu, Shi-Hui Zhang, Nazeer Hussain Khan, Dong-Dong Wu, Xiao-Ju Zhang, Juan Cen
Hepatocellular carcinoma (HCC) is a disease with high morbidity, high mortality, and low cure rate. Hyaluronic acid (HA) is widely adopted in tissue engineering and drug delivery. 5-(4-Hydroxyphenyl)-3H-1, 2-dithiol-3-thione (ADT-OH) is one of commonly used H2S donors. In our previous study, HA-ADT was designed and synthesized via coupling of HA and ADT-OH. In this study, compared with sodium hydrosulfide
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Correlation between Macrophage Polarization and PD-L1-Related Tumor Microenvironmental Alteration and Metastasis in Pancreatic Ductal Adenocarcinoma J. Oncol. (IF 4.501) Pub Date : 2023-3-6 Jiangning Gu, Feng Gao, Bin Fan, Shiqi Xu, Haifeng Luo, Jie Zhang, Qi Jiang, Chenqi Wang, Guang Tan, Wenjing Qi, Jian Du, Siqian Huang, Xiaohong Sun, Dan Chen
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis; nearly 80% patients have regional or distant metastasis when diagnosed. Tumor microenvironment (TME) alteration and epithelial-to-mesenchymal transition (EMT) have been reported to play a key role in cancer metastasis. However, the correlation between TME and EMT was poorly studied in PDAC. This study aims
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A Simple-to-Use Nomogram for Predicting Postoperative Early Death Risk in Elderly Patients with Spinal Tumors: A Population-Based Study J. Oncol. (IF 4.501) Pub Date : 2023-3-4 Zhangheng Huang, Zhen Zhao, Yuheng Liu, Zhigang Zhou, Weifei Zhang, Qingquan Kong, Yaozhi He
Background. For elderly patients with primary spinal tumors, surgery is the best option for many elderly patients, in addition to palliative care. However, due to the unique physical function of elderly patients, the short-term prognosis is often unpredictable. It is therefore essential to develop a novel nomogram as a clinical aid to predict the risk of early death for elderly patients with primary
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Antitumor Therapy Targeting the Tumor Microenvironment J. Oncol. (IF 4.501) Pub Date : 2023-3-3 Yuewen Gao, Zhengwu Pan, Hongqi Li, Fei Wang
The development and progression of tumors in human tissues extensively rely on its surrounding environment, that is, tumor microenvironment which includes a variety of cells, molecules, and blood vessels. These components are modified, organized, and integrated to support and facilitate the growth, invasion, and metabolism of tumor cells, suggesting them as potential therapeutic targets in anticancer
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Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway J. Oncol. (IF 4.501) Pub Date : 2023-3-3 Yawei Bi, Kun Cao, Yuan Wang, Wei Yang, Na Ma, Xiao Lei, Yuanyuan Chen
NSCLC (non-small-cell lung cancer) is an aggressive form of lung cancer and accompanies high morbidity and mortality. This study investigated the function and associated mechanism of MMP10 during radiotherapy of NSCLC. MMP10 expression in patients and their overall survival rate were assessed through GEPIA. Protein expression was tested by western blotting. Radioresistance was detected in vitro by
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The Efficacy and Safety of Afatinib in Non-Small Cell Lung Cancer Patients with Brain Metastasis: A Meta-Analysis J. Oncol. (IF 4.501) Pub Date : 2023-3-2 Hui Jin, Xin He, Ping Liang, Juan Hou, Bin Li, Ping Wang
Aim. The aim of this study is to evaluate the efficacy and safety of afatinib in the treatment of non-small cell lung cancer (NSCLC) patients with brain metastasis based on meta-analysis. Methods. Related literatures were searched in the following databases: EMbase, PubMed, China Knowledge Network (CNKI), Wanfang, Weipu, Google Scholar, the China Biomedical Literature Service System, and other databases
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Upregulation of APOC1 Promotes Colorectal Cancer Progression and Serves as a Potential Therapeutic Target Based on Bioinformatics Analysis J. Oncol. (IF 4.501) Pub Date : 2023-3-1 Weiwei Tang, Hanyuan Liu, Xiao Li, Theng Choon Ooi, Nor Fadilah Rajab, Hongyong Cao, Razinah Sharif
Background. Approximately 10% of cancer patients worldwide have colorectal cancer (CRC), a prevalent gastrointestinal malignancy with substantial mortality and morbidity. The purpose of this work was to investigate the APOC1 gene’s expression patterns in the CRC tumor microenvironment and, using the findings from bioinformatics, to assess the biological function of APOC1 in the development of CRC.
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The Cuproptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Immune Cell Infiltration in Hepatocellular Carcinoma J. Oncol. (IF 4.501) Pub Date : 2023-2-27 Ying Li, Kaichao Song, Wensheng Zheng
Background. Hepatocellular carcinoma (HCC), ranking as one of the most common malignant tumors, is one of the leading causes of cancer death, with a poor prognosis. Cuproptosis, a novel programmed cell death modality that has just been confirmed recently, may play an important role in HCC prognosis. Long noncoding RNA (LncRNA) is a key participant in tumorigenesis and immune responses. It may be of
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New Personal Model for Forecasting the Outcome of Patients with Histological Grade III-IV Colorectal Cancer Based on Regional Lymph Nodes J. Oncol. (IF 4.501) Pub Date : 2023-2-25 Jun Yang, Wei Jin, Zhuoqun Lin, Shaotang Li
Background. Metastases at regional lymph nodes could easily occur in patients with high-histological-grade colorectal cancer (CRC). However, few models were built on the basis of lymph nodes to predict the outcome of patients with histological grades III-IV CRC. Methods. Data in the Surveillance, Epidemiology, and End Results databases were used. Univariate and multivariate analyses were performed
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Development and Verification of a Prognostic Stemness-Related Gene Signature in Triple-Negative Breast Cancer J. Oncol. (IF 4.501) Pub Date : 2023-2-25 Xueqi Ou, Yeru Tan, Guanfeng Gao, Song Wu, Jinhui Zhang, Hailin Tang, Hongbo Zhu, Anli Yang
Background. It is well known that cancer stem cells can induce cancer metastasis, which causes the majority of cancer-related death, especially in triple-negative breast cancer (TNBC). TNBC features a high metastatic rate and low metastasis-free survival and is regarded as the most malignant subtype of breast cancer. The purpose of this study is to explore prognostic biomarkers that can predict metastasis
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Efficacy of Recombinant Human Endostatin plus Neoadjuvant Chemotherapy for Osteosarcoma and Its Influence on Serum VEGF and MMP-9 Levels J. Oncol. (IF 4.501) Pub Date : 2023-2-25 Wei Sui, Guanghui Lin
Objective. To investigate the efficacy of recombinant human endostatin (rh-Endo) plus neoadjuvant chemotherapy (NACT) for osteosarcoma (OSA) and its influence on serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9). Methods. The case data of 141 OSA patients presented to the North District, Xiangyang Central Hospital Affiliated to Hubei University of Arts and Sciences
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LncRNA LINC01207 Could Positively Regulate the Development of Colorectal Cancer J. Oncol. (IF 4.501) Pub Date : 2023-2-24 Gaowu Hu, Wenquan Chen, Wei Peng, Yongqing Cao
Background. LINC01207 expression is associated with colorectal cancer progression. However, the exact role of LINC01207 in colorectal cancer (CRC) is not clear, and further exploration is needed. Methods. Gene expression data of the GSE34053 database were used to explore the differential expressed genes (DEGs) between colon cancer cells and normal cells. The gene expression profiling interactive analysis
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Dose-Response Relationship between Head and Neck Radiation and Damages to Gustatory Cells in Mice J. Oncol. (IF 4.501) Pub Date : 2023-2-24 Shanshan Bu, Bin Qiu, Hui Xue, Hongxiang Liu, Xiushen Wang
Objective. To investigate the dose-response relationship between radiation to the head and neck regions and damage observed in mice gustatory cells. Materials and Methods. A total number of 45 mice (C57BL/6) (aged 8–12 weeks) were enrolled in this study. The head and neck regions of the mice were irradiated at doses of 8 Gy (low-dose group, n = 15), 16 Gy (moderate-dose group, n = 15), and 24 Gy (high-dose
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GINS2 Promotes Osteosarcoma Tumorigenesis via STAT3/MYC Axis J. Oncol. (IF 4.501) Pub Date : 2023-2-23 Bingkai Ren, Yibin Zheng, Lizhong Nie, Fanhui Wu, Leiwen Huang, Jingdu Wei, Dong Yang
GINS2 is overexpressed in several cancers, but little is known about its role in osteosarcoma (OS). A series of in vivo and in vitro experiments were conducted to explore the role of GINS2 in OS. In this study, we demonstrated that GINS2 was found to be highly expressed in OS tissues and cell lines, which was associated with poor outcomes in OS patients. GINS2 knockdown hindered the growth and induced
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METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer J. Oncol. (IF 4.501) Pub Date : 2023-2-23 Qianhui Zhou, Xihua Lai, Yan Gao, Quefei Chen, Yuzhu Xu, Yi Liu
N6-methyladenosine (m6A) is an abundant eukaryotic mRNA modification involved in regulating the formation and metastasis of nonsmall cell lung cancer (NSCLC). We collected clinical NSCLC tissue and paracarcinoma tissue. Then methyltransferase-like 14 (METTL14), pleomorphic adenoma gene like-2 (PLAGL2), and β-catenin expressions were assessed using quantitative real-time PCR and western blot. PLAGL2
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Circulating the HLA-DR+ T Cell Ratio Is a Prognostic Factor for Recurrence of Patients with Hepatocellular Carcinoma after Curative Surgery J. Oncol. (IF 4.501) Pub Date : 2023-2-23 Rui-Qian Gao, Jing-Han Sun, Yong-Hui Ma, Yu-Wei Xie, Guan-Ming Shao, Cong Wang, Bin Tan, Kui Liu, Kun Li, Na Li, Wei-Yu Hu, Jingyu Cao
Background. HLA-DR+ T cell, accounting for 1.2%–5.8% of peripheral lymphocyte, is a type of activated T lymphocyte. This retrospective study aimed to evaluate the prognostic value of HLA-DR+ T cell for progression-free survival (PFS) and overall survival (OS) in hepatocellular carcinoma (HCC) patients after curative surgery. Patients and Methods. Clinicopathological data of 192 patients who underwent
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Construction of a Novel Diagnostic Model Based on Ferroptosis-Related Genes for Hepatocellular Carcinoma Using Machine and Deep Learning Methods J. Oncol. (IF 4.501) Pub Date : 2023-2-23 Shiming Yi, Chunlei Zhang, Ming Li, Jiafeng Wang
Hepatocellular carcinoma (HCC) is one of the most general malignant tumors. Ferroptosis, a type of necrotic cell death that is oxidative and iron-dependent, has a strong correlation with the development of tumors and the progression of cancer. The present study was designed to identify potential diagnostic Ferroptosis-related genes (FRGs) using machine learning. From GEO datasets, two publicly available
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OLFML2A Overexpression Predicts an Unfavorable Prognosis in Patients with AML J. Oncol. (IF 4.501) Pub Date : 2023-2-22 Xuan Lu, Ying Li, Yan Yang, Wanchuan Zhuang, Xingxing Chai, Chen Gong
Background. Acute myeloid leukemia (AML) is a malignant clonal disease of the myeloid hematopoietic system. Clinically, standard treatment options include conventional chemotherapy as well as hematopoietic stem cell transplantation. Among them, chemotherapy has a remission rate of 60% to 80% and nearly 50% relapse in consolidation therapy. Some patients have a poor prognosis due to the presence of
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Identification of Prognostic Aging-Related Genes Associated with Immune Cell Infiltration in Glioblastoma J. Oncol. (IF 4.501) Pub Date : 2023-2-21 Xiaopeng Zhu, Xun Chen, Zhao Liu, Bihui Yang, Yuxiang Zhou, Sian Pan, Yongkai Huang, Deqing Han, Yiqian Zeng, Chao Liu
Background. Aging is recognized as a main tumor risk factor, and thus aging has become a field of interest in the tumor research field. Glioblastoma multiforme represents the most typical primary malignant intracranial tumor, particularly in the elderly. However, the association between aging-related genes (AGs) and GBM prognosis remains unknown. As a result, the primary goal of this study was to determine
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Retinoblastoma-Binding Protein 5 Regulates H3K4 Methylation Modification to Inhibit the Proliferation of Melanoma Cells by Inactivating the Wnt/β-Catenin and Epithelial-Mesenchymal Transition Pathways J. Oncol. (IF 4.501) Pub Date : 2023-2-21 Zhiqin Yang, Yue Jia, Shaojia Wang, Yongjun Zhang, Wen Fan, Xin Wang, Liang He, Xiaoyu Shen, Xiangqun Yang, Yi Zhang, Hongying Yang
Histone 3 lysine 4 methylation (H3K4me), especially histone 3 lysine 4 trimethylation (H3K4me3), is one of the most extensively studied patterns of histone modification and plays crucial roles in many biological processes. However, as a part of H3K4 methyltransferase that participates in H3K4 methylation and transcriptional regulation, retinoblastoma-binding protein 5 (RBBP5) has not been well studied