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Extensive Stage Small-Cell Lung Cancer with Cystic Brain Metastases: A Report of Two Cases Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-18 Fei Cai, Di Wu, Junling Liu, Shuxi Song, Jingyu Li, Zhendong Zheng, Long Xu
Objective: Cystic brain metastases (BMs) are rare in small cell lung cancer (SCLC), and there are limited data on the treatment and prognosis of cystic BMs. Whole brain radiotherapy has been the mainstay for BMs since several years. Immune checkpoint inhibitors in extensive stage small cell lung cancer (ES-SCLC) have been shown to be suitable for patients who experienced better overall survival and
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Efficacy and Safety of Hepatic Arterial Infusion Therapy with Cinobufacini in Advanced Hepatocellular Carcinoma with Macrovascular Invasion: A Retrospective Cohort Study Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-14 Tao Xue, Hongbin Yu, Wenming Feng, Yao Wang, Shiyong Wu, Lili Wang, Peiqin Zhu, Jianming Guan, Quan Sun
Background: The presence of macrovascular invasion (MVI) is associated with poor prognosis in advanced hepatocellular carcinoma (HCC). This study aims to evaluate the efficacy and safety of Cinobufacini therapy via hepatic arterial infusion (HAI) in advanced HCC patients with MVI. Methods: The clinical records of 130 consecutive patients with unresectable advanced HCC and MVI who had received Cinobufacini
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Immune-Related Adverse Event-Related Adrenal Insufficiency Mediates Immune Checkpoint Inhibitors Efficacy in Cancer Treatment Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-14 Shasha Zhang, Jianhua Wu, Yue Zhao, Jingjing Zhang, Xiaoyun Zhang, Chensi Wu, Zhidong Zhang, Zhanjun Guo
Purpose: Immune checkpoint inhibitors (ICIs) have significantly improved the outcomes of patients with cancer; however, these agents may initiate immune-related adverse events (irAEs). Previous studies have demonstrated a robust correlation between disease prognosis and the occurrence of irAEs, specifically skin or endocrine irAEs. Herein, we aimed to evaluate the correlation between irAE-related adrenal
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SIRT3 Expression Predicts Overall Survival and Neoadjuvant Chemosensitivity in Triple-Negative Breast Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-08 Lvwen Ning, Ni Xie
Background: The Sirtuin (SIRT) family consists of seven evolutionary conserved NAD-dependent deacetylases that play important roles in various cancers, including breast cancer (BC). SIRTs expression has been reported to have prognostic value in BC, but these studies used limited sample size and yielded inconsistent conclusions. This study evaluated the association of SIRT3 and other SIRT family members
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High Expression of WT1 and Low Expression of p53 in Archived Blocks of Children with Wilms Tumor in South Western Uganda Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-06 Brian Ssenkumba, Barnabas Atwiine, Yekosani Mitala, Janet Adongo, Samuel Olowo, Rita Nabulya, Amnia Diaz Anaya, Raymond Atwine
Purpose: The determination of the presence or absence of anaplasia in Wilms tumor is difficult sometimes creating diagnostic errors and is worsened by the use of neoadjuvant chemotherapy, which causes cellular alterations that may mimic anaplasia. This study described the histological features of Wilms tumor and their association with WT1 and p53 expression in archived specimens in South Western Uganda
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The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review Cancer Manage. Res. (IF 3.3) Pub Date : 2024-03-04 Xiaohong Yao, Min Feng, Wei Wang
Abstract: Endometrial cancer shows high histological and molecular heterogeneity. The POLE mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as POLE-mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for
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SHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial–Mesenchymal Transition [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-02-24 Huaqin Yuan, Jun Zhao, Yang Yang, Rongfu Wei, Liangxue Zhu, Jie Wang, Meiqing Ding, Mingyun Wang, Yanhong Gu
Retraction for the article SHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial–Mesenchymal Transition
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MicroRNA-506 Regulates Apoptosis in Retinoblastoma Cells by Targeting Sirtuin 1 [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-02-24 Zhidu Song, Hailiang Wang, Fangwei Zong, Chao Zhu, Ying Tao
Retraction for the article MicroRNA-506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1
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Investigation of the Proteasome 26S Subunit, ATPase Family Genes as Potential Prognostic Biomarkers and Therapeutic Targets for Hepatocellular Carcinoma Cancer Manage. Res. (IF 3.3) Pub Date : 2024-02-13 Lei Feng, Ning Zhang, Lan Luo, Jie Liu, Yong Yao, Ming-Sheng Gao, Jin Pan, Cai He
Background: Several studies suggest that Proteasome 26S Subunit, ATPase (PSMC) family genes are of great importance in tumor progression and spreading, but the study for systematic evaluation of the function of PSMC genes in hepatocellular carcinoma (HCC) is currently lacking. Methods: The functions of PSMC genes in HCC were analyzed using multiple online databases, including the TCGA database, GEO
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Crossing the River by Feeling the Stones: Experiences with PD-1 Inhibitors in Geriatric Oncology People, a Case Report and Literature Review Cancer Manage. Res. (IF 3.3) Pub Date : 2024-02-05 Hang Yin, Xia Zhang, Manjie Zhang, Hong Tang, Chunxia Zhang, Jia Li
Abstract: Currently, lung cancer remains one of the deadliest cancers, with a very high mortality rate, accounting for approximately 18% of all cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancer deaths. In particular, elderly patients generally have poor tolerance to chemotherapy or cannot tolerate chemotherapy. This case analysis focuses on an elderly patient
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Feasibility and Tolerability of Anlotinib Plus PD-1 Blockades for Patients with Treatment-Refractory Metastatic Colorectal Cancer: A Retrospective Exploratory Study Cancer Manage. Res. (IF 3.3) Pub Date : 2024-02-01 Hua Bai, Wen-Hui Wang, Fan-Fan Zhou, Dan Yang, Rui-Jun Li
Objective: Therapeutic regimens are relatively scarce among patients with treatment-refractory metastatic colorectal cancer (CRC). This study aimed to determine the feasibility and tolerability of anlotinib plus PD-1 blockades in patients with treatment-refractory metastatic CRC retrospectively. Methods: A total of 68 patients with previously treated metastatic CRC who received anlotinib plus PD-1
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Palliative Gastrectomy Plus Chemotherapy versus Chemotherapy Alone for Incurable Advanced Gastric Cancer: A Meta-Analysis [Corrigendum] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-25 Pei Wu, Pengliang Wang, Bin Ma, Songchen Yin, Yuen Tan, Wenbin Hou, Zhenning Wang, Huimian Xu, Zhi Zhu
Corrigendum for the article Palliative gastrectomy plus chemotherapy versus chemotherapy alone for incurable advanced gastric cancer: a meta-analysis
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Long-Noncoding RNA CASC9 Promotes Progression of Non-Small Cell Lung Cancer by Promoting the Expression of CDC6 Through Binding to HuR [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-22 Xudong Zhang, Ting Lian, Wenjun Fan, Guangwei Zhang, Ziwei Chen, Xingchun Gou, Rajiv Kumar Jha
Retraction for the article Long-Noncoding RNA CASC9 Promotes Progression of Non-Small Cell Lung Cancer by Promoting the Expression of CDC6 Through Binding to HuR
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LncRNA EMX2OS Induces Proliferation, Invasion and Sphere Formation of Ovarian Cancer Cells via Regulating the miR-654-3p/AKT3/PD-L1 Axis [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-22 Meng Duan, Meixia Fang, Changhe Wang, Hongyan Wang, Meng Li
Retraction for the article LncRNA EMX2OS Induces Proliferation, Invasion and Sphere Formation of Ovarian Cancer Cells via Regulating the miR-654-3p/AKT3/PD-L1 Axis
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LncRNA HOTAIRM1 Inhibits the Proliferation and Invasion of Lung Adenocarcinoma Cells via the miR-498/WWOX Axis [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-22 Tian-jun Chen, Fei Gao, Tian Yang, Hong Li, Yang Li, Hui Ren, Ming-wei Chen
Retraction for the article LncRNA HOTAIRM1 Inhibits the Proliferation and Invasion of Lung Adenocarcinoma Cells via the miR-498/WWOX Axis
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LINC00963 Promotes Ovarian Cancer Proliferation, Migration and EMT via the miR-378g/CHI3L1 Axis [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-22 Wei Liu, Yu-Jia Yang, Qiang An
Retraction for the article LINC00963 Promotes Ovarian Cancer Proliferation, Migration and EMT via the miR-378g /CHI3L1 Axis
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ZNF217: An Oncogenic Transcription Factor and Potential Therapeutic Target for Multiple Human Cancers Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-18 Yepeng Wang, Chao Ma, Xuekun Yang, Jun Gao, Zhigang Sun
Abstract: Zinc finger protein 217 (ZNF217) is one of the well-researched members of the Krüppel-like factor transcription factor family. ZNF217 possesses a characteristic structure of zinc finger motifs and plays a crucial role in regulating the biological activities of cells. Recent findings have revealed that ZNF217 is strongly associated with multiple aspects of cancer progression, impacting patient
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The Association of Inflammatory Related Markers with the Prognosis in Elderly Patients with Colorectal Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-18 Shih Wei Chiang
Background: Colorectal cancer (CRC) is a common malignancy, especially among older adults. Inflammation has been implicated in cancer progression, making inflammatory indices potential prognostic markers. This study aimed to evaluate the prognostic significance of the Glasgow prognostic score (GPS), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/C-reactive protein ratio
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The Correlation Between Low-Dose Radiotherapy Area of the Mediastinum and CD8+T Cells and the Efficacy of Radiotherapy for Non-Small Cell Lung Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-12 Hang Wang, Yang Li, Pingping Hu, Jiandong Zhang
Background: Radiation therapy (RT) can cause changes in peripheral blood immune cells. The relationship between the efficacy of radiation therapy for non-small cell lung cancer (NSCLC) and immune cell changes and the study of how mediastinal radiation dose parameters affect immune cell changes is still unclear. This study aims to analyze the relationship between immune cell changes induced by radiotherapy
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Correlation Between DCAMKL-1 Protein Expression and K-ras Gene Mutation in Colorectal Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-05 Xuefang Wu, Shuang Li, Yingchun Yang, Jianjun Hu, Tongyin Yang
Aim: To investigate the correlation between doublecortin and CaM kinase-like-1 (DCAMKL-1) protein expression, K-ras gene mutation, and their impact on patient prognosis in colorectal cancer (CRC). Methods: Immunohistochemistry was used to detect the expression of DCAMKL-1 protein in 60 cases of colorectal adenoma, 82 cases of CRC (including 65 cases of lymph node metastasis) and paraffin-embedded paracancerous
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Resumption of Intravenous Anti-Cancer Therapy in Breast Cancer: A Real-World Experience During the SARS-CoV-2 Pandemic Cancer Manage. Res. (IF 3.3) Pub Date : 2024-01-03 Fang Yang, Cong Li, Yuling Qiu, Xinjie Chen, Kelin Zheng, Donglin Kang, Yin Zhang, Baorui Liu, Yongzhong Yao, Li Xie
Purpose: The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has delayed medical consultations, especially for patients receiving intravenous anti-cancer therapy. We aim to investigate alterations in immune function among breast cancer patients who experience delayed intravenous therapy due to SARS-CoV-2 infection. Patients
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A Case of Multi-Organ Tuberculosis Misdiagnosed as Lung Cancer and a Literature Review Cancer Manage. Res. (IF 3.3) Pub Date : 2023-12-27 Meng Hu
Background: Tuberculosis (TB) is a very common and easily diagnosed as a malignancy. However, studies have described the difference between TB and lung cancer. Single-organ TB and lung cancer are often easily distinguished clinically. Atypical systemic hematogenous disseminated TB (HDTB) is uncommon, including rare cases involving multiple organs such as cervical lymph nodes, pleura, liver, and lung
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Current Molecular and Clinical Landscape of ATRT – The Link to Future Therapies Cancer Manage. Res. (IF 3.3) Pub Date : 2023-12-07 Katharina Gastberger, Victoria E Fincke, Marlena Mucha, Reiner Siebert, Martin Hasselblatt, Michael C Frühwald
Abstract: ATRT is a highly aggressive and rare pediatric CNS tumor of very young children. Its genetic hallmark is bi-allelic inactivation of SMARCB1 encoding INI1. Rarely SMARCA4 encoding BRG1 is affected. Up to 30% are associated with constitutional heterozygous pathogenic variants in one of the two genes, giving rise to the Rhabdoid-Tumor-Predisposition-Syndromes (RTPS) 1 and 2. Characteristic DNA
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Epigenome-Driven Strategies for Personalized Cancer Immunotherapy Cancer Manage. Res. (IF 3.3) Pub Date : 2023-12-01 Gabriel Iudy Yamaguchi Rocha, Jonathas Eduardo Miranda Gomes, Michel Lopes Leite, Nicolau B da Cunha, Fabricio F Costa
Abstract: Fighting cancer remains one of the greatest challenges for science in the 21st century. Advances in immunotherapy against different types of cancer have greatly contributed to the treatment, remission, and cure of patients. In this context, knowledge of epigenetic phenomena, their relationship with tumor cells and how the immune system can be epigenetically modulated represent some of the
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Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer [Letter] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-12-01 Sri Winarni, Wiwin Martiningsih, Ekowati Retnaningtyas
Letter for the article Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer
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Challenging Diagnosis: Unmasking the Enigma of Imaging Findings with Lung Schwannomas Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-27 Cui-Ping Li, Lei Li, Lin-Ming Su, Shu-Sheng Zhu, Meng-Jie Li
Abstract: Schwannomas are benign slow-growing tumors arising from the embryonic neural crest cells of the nerve sheaths of peripheral and cranial nerves, and they are a rare type of soft tissue mass that is usually always solitary. Generally, it grows in the head, neck, and flexor portions of the limbs, where many nerves are located. Schwannomas of the lung are extremely rare. Fewer than ten cases
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Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-22 Wei-Wei Liu, Wei-Dong Li, Yan-Ju Zhang, Man-Li Zhang
Retraction for the article Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis
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MiR-625 Inhibits Tumor Cell Invasion, Migration and EMT by Negatively Regulating the Expression of Resistin in Non-Small Cell Lung [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-22 Yongsheng Zhao, Renyan Zheng, Dong Ning, Fei Xie
Retraction for the article MiR-625 Inhibits Tumor Cell Invasion, Migration and EMT by Negatively Regulating the Expression of Resistin in Non-Small Cell Lung
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Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-17 Yi-Ming Gao, Yan Pei, Fei-Fei Zhao, Ling Wang
Abstract: Osteosarcoma is an extremely malignant tumor, and its pathogenesis is complex and remains incompletely understood. Most cases of osteosarcoma are accompanied by symptoms of bone loss or result in pathological fractures due to weakened bones. Enhancing the survival rate of osteosarcoma patients has proven to be a long-standing challenge. Numerous studies mentioned in this paper, including
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Tangeretin Inhibits Hepatocellular Carcinoma Proliferation and Migration by Promoting Autophagy-Related BECLIN1 [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-16 Jiao Zheng, Yaqin Shao, Yu Jiang, Fang Chen, Sulai Liu, Nanhui Yu, Dandan Zhang, Xiehong Liu, Lianhong Zou
Retraction for the article Tangeretin inhibits hepatocellular carcinoma proliferation and migration by promoting autophagy-related BECLIN1
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Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer [Corrigendum] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-16 Carielle Joy Rio, Taichi Goto, Chao-Pin Hsiao, Alexander LR Ross, Leorey N Saligan
Corrigendum for the article Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer
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The Prognosis of Advanced Non-Small Cell Lung Cancer Patients with Precision-Targeted Therapy Guided by NGS Testing or Routine Testing Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-16 Tingting Tu, Dandan Chen, Houjun Jiang, Jianhua Ma, Hongwei Wang, Cheng Chen
Purpose: We aim to observe the potential survival benefits of driver gene-guided targeted therapy in advanced non-small cell lung cancer (NSCLC) patients compared to non-targeted therapy. Additionally, the study aims to assess whether Next-generation sequencing technology (NGS)-guided targeted therapy can provide survival advantages for advanced NSCLC patients compared to conventional Epidermal growth
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Combining Clinicopathologic and Ultrasonic Features for Predicting Skip Metastasis of Lateral Lymph Nodes in Papillary Thyroid Carcinoma Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-15 Xin Zhang, Ying Chen, Wanyin Chen, Zheng Zhang
Background: Skip metastasis, regarded as lateral lymph node metastasis (LLNM) without involving the central lymph node metastasis (CLNM), in papillary thyroid carcinoma (PTC) patients is commonly unpredictable. The purpose of the present research was to investigate the independent risk factors of skip metastasis in patients with PTC. Methods and Materials: In the present research, 228 consecutive PTC
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Post-Operative Poor Sleep Quality and Its Associated Factors Among Non-Small Cell Lung Cancer Patients: A Cross-Sectional Study Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-15 Xinxin Chen, Yachen Hu, Jiaxin Fan, Yumei Li
Objective: The study aimed to determine the post-operative prevalence and factors associated to poor sleep quality in non-small cell lung cancer (NSCLC) patients in China. Methods: NSCLC patients (n=307) who underwent thoracoscopic surgery at the Department of Thoracic Surgery of Shanghai Pulmonary Hospital were enrolled in this study. The Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety
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Characteristics of Real-World Patients with High-Risk BRAFV600E/K-Mutated Melanoma Receiving Adjuvant Treatment with Dabrafenib Plus Trametinib After Surgical Resection, Through the Italian Managed Access Program Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-11 Pietro Quaglino, Paolo A Ascierto, Francesca Consoli, Paola Queirolo, Francesco Spagnolo, Maria Francesca Morelli, Rossana Berardi, Vanna Chiarion-Sileni, Marco Tucci, Teresa Troiani, Barbara Melotti, Ernesto Rossi, Mario Mandala, Gaetana Rinaldi, Ilaria Gioia Marcon, Matteo Pizzuti, Michele Del Vecchio
Purpose: Real-world data from patients with BRAFV600-mutated, resected, stage III melanoma treated with dabrafenib plus trametinib as adjuvant targeted therapy are limited, and it is important to gain an understanding of the characteristics of this patient population, as well as of the patient journey. Here we aimed to describe the characteristics, dosage reductions and discontinuations in patients
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LINC00261 Inhibits Esophageal Cancer Radioresistance by Down-Regulating microRNA-552-3p and Promoting DIRAS1 [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-11 Baolong Yang, Hongbing Ma, Yan Bian
Retraction for the article LINC00261 Inhibits Esophageal Cancer Radioresistance by Down-Regulating microRNA-552-3p and Promoting DIRAS1
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LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-10 Xiancheng Han, Jing Liu, Yongguo Liu, Linkai Mou, Chunlong Li
Retraction for the article LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p
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Prognosis and Biological Function of miR-3195 in Non-Small Cell Lung Cancer [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-10 Yingjie Lu, Xuelin Zhang, Huibiao Zhang, Zhenghong Zhu
Retraction for the article Prognosis and Biological Function of miR-3195 in Non-Small Cell Lung Cancer
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Long Non-Coding RNA ZNF667-AS1 Knockdown Curbs Liver Metastasis in Acute Myeloid Leukemia by Regulating the microRNA-206/AKAP13 Axis [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-07 Nan Wang, Yanping Feng, Jinye Xie, Hui Han, Qian Dong, Weijia Wang
Retraction for the article Long Non-Coding RNA ZNF667-AS1 Knockdown Curbs Liver Metastasis in Acute Myeloid Leukemia by Regulating the microRNA-206/AKAP13 Axis
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Outcome of Thromboembolic Events and Its Influence on Survival Time of Advanced NSCLC Patients Treated with Antiangiogenic Therapy Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-06 Wei-Fan Ou, Pei-Ya Liao, Yu-Wei Hsu, Yen-Hsiang Huang, Kuo-Hsuan Hsu, Jeng-Sen Tseng, Gee-Chen Chang, Tsung-Ying Yang
Background: Antiangiogenetic therapy and lung cancer, per se, are associated with an increased risk of thromboembolic events (TE). We aim to evaluate the pattern and outcome of TE as well as its influence on survival time of advanced non-small cell lung cancer (NSCLC) patients receiving antiangiogenic therapy. Methods: This was a retrospective cohort study, which included advanced NSCLC patients receiving
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Effect of Enfortumab Vedotin Dose Adjustment on Efficacy in Metastatic Urothelial Carcinoma: A Retrospective Single-Center Experience Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-06 Anna Clennon, Megan Hinkley, Kristen Nymberg, Lauren Ledbetter, Demond Handley, Eric McLaughlin, Amir Mortazavi, Katharine A Collier
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Profile of Capmatinib for the Treatment of Metastatic Non-Small Cell Lung Cancer (NSCLC): Patient Selection and Perspectives Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-03 Madison Fraser, Nagashree Seetharamu, Matthew Diamond, Chung-Shien Lee
Abstract: Aberrant c-MET (Mesenchymal–Epithelial Transition) signaling contributes to cancer cell development, proliferation, and metastases of non-small cell lung cancer (NSCLC). MET exon 14 (METex14) skipping mutation is noted in approximately 4% of NSCLC cases and is targetable with the recently approved tyrosine kinase inhibitors capmatinib and tepotinib. Capmatinib, the focus of this review article
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Fecal Carriage of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Enterobacteriaceae Among Oncology and Non-Oncology Patients at Jimma Medical Center in Ethiopia: A Comparative Cross-Sectional Study Cancer Manage. Res. (IF 3.3) Pub Date : 2023-11-01 Wubalech Temsegen, Kasahun Gorems, Mekidim Mekonnen, Diriba Fufa, Tesfaye Kassa
Purpose: Extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacteriaceae (CPE) are among the major threats to global health because of their encoded protection against key antibiotics. Methods: A comparative cross-sectional study was conducted among oncology and non-oncology patient groups (1:1; n = 214) on a consecutive sampling approach. Stool or rectal swab was collected from
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Comparison of Perioperative Outcomes Between Laparoscopic and Robot-Assisted Adrenalectomy for Large Pheochromocytoma (≥ 5cm): A Retrospective Study Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-31 Yuling Cheng, Yu Zhu
Purpose: The objective of this study was to compare perioperative outcomes in patients with large (≥ 5cm) pheochromocytomas who underwent adrenalectomy. Patients and Methods: We retrospectively reviewed patients who underwent laparoscopic adrenalectomy (LA) and robot-assisted adrenalectomy (RA) for large pheochromocytoma (≥ 5cm) at our center between January 2015 to February 2023. We compared the perioperative
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Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-31 Carielle Joy Rio, Taichi Goto, Chao-Pin Hsiao, Alexander LR Ross, Leorey N Saligan
Purpose: Prostate cancer and its treatment may affect patients’ sexual function and social wellbeing. This study investigated the relationship between social/family wellbeing and sexual health in patients with prostate cancer. Additionally, the moderating effect of clinical characteristics on this relationship was also explored. Patients and Methods: This is a descriptive correlational study using
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Treatment at Relapse for Synovial Sarcoma of Children, Adolescents and Young Adults: From the State of Art to Future Clinical Perspectives Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-27 Andrea Ferrari, Pablo Berlanga, Susanne Andrea Gatz, Reineke A Schoot, Max M van Noesel, Shushan Hovsepyan, Stefano Chiaravalli, Luca Bergamaschi, Veronique Minard-Colin, Nadege Corradini, Rita Alaggio, Patrizia Gasparini, Bernadette Brennan, Michela Casanova, Sandro Pasquali, Daniel Orbach
Abstract: While the overall prognosis is generally quite satisfactory in children, adolescents and young adults with localised synovial sarcoma at first diagnosis, the outcome remains poor for patients after relapse. Conversely to the front-line standardised treatment options, patients with relapse generally have an individualised approach and to date, there is still a lack of consensus regarding standard
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Navigating Sepsis: New Prognostic Tools [Letter] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-17 Yalcin Golcuk, Burcu Kaymak Golcuk
Letter for the article A New Scoring System for Predicting Mortality in Hematological Malignancies with Sepsis: A Derivation and Validation Study
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Large-Scale Identification of Lysine Crotonylation Reveals Its Potential Role in Oral Squamous Cell Carcinoma Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-17 Xiteng Yin, Hongbo Zhang, Zheng Wei, Yufeng Wang, Shengwei Han, Meng Zhou, Wenguang Xu, Wei Han
Purpose: Lysine crotonylation, an emerging posttranslational modification, has been implicated in the regulation of diverse biological processes. However, its involvement in oral squamous cell carcinoma (OSCC) remains elusive. This study aims to reveal the global crotonylome in OSCC under hypoxic conditions and explore the potential regulatory mechanism of crotonylation in OSCC. Methods: Liquid-chromatography
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Value of Molybdenum Target X-Ray and High-Frequency Color Doppler Flow Imaging in Early Diagnosis of Breast Carcinoma: A Comparative Analysis Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-16 Xia Li, Shuang Xu, Liu-Wei Hao, Xiao-Ning Zhou
Background: Breast carcinoma (BC) threatens the physical and mental health of women worldwide, and early diagnosis is important for improving patient outcomes and ensuring successful treatment. Purpose: This research mainly aims to compare and analyze the value of molybdenum target X-ray and high-frequency color Doppler flow imaging (CDFI) in the early diagnosis of BC. Methods: First, 102 patients
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T Cell Invigoration is Associated with the Clinical Response to Anti-PD-1-Based Immunotherapy in Non-Small Cell Lung Cancer Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-10 Hui Wu, Gui Zhen Weng, Li Na Sun, Zhang Chi Pan, Lu Zhang, Qiang Chen, Chun Mei Shi
Purpose: Immune checkpoint inhibitors (ICIs) have been developed for clinical application and proven effective for non-small cell lung cancer (NSCLC). Blockade of the programmed cell death 1 (PD-1) protein can partially reinvigorate circulating exhausted-phenotype CD8+ T cells (Tex cells) in preclinical models, however the clinical implication in anti-PD-1-based immunotherapy in NSCLC is unknown. Methods:
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Clinical Insight on Proton Therapy for Paediatric Rhabdomyosarcoma Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-10 Sabina Vennarini, Francesca Colombo, Alfredo Mirandola, Stefano Chiaravalli, Ester Orlandi, Maura Massimino, Michela Casanova, Andrea Ferrari
Abstract: This paper offers an insight into the use of Proton Beam Therapy (PBT) in paediatric patients with rhabdomyosarcoma (RMS). This paper provides a comprehensive analysis of the literature, investigating comparative photon-proton dosimetry, outcome, and toxicity. In the complex and multimodal scenario of the treatment of RMS, clear evidence of the therapeutic superiority of PBT compared to other
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NPTX1 Promotes Metastasis via Integrin/FAK Signaling in Gastric Cancer [Retraction] Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-09 Hongfei Yan, Chunlei Zheng, Zhi Li, Bowen Bao, Bowen Yang, Kezuo Hou, Xiujuan Qu, Jiawen Xiao, Xiaofang Che, Yunpeng Liu
Retraction for the article NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer
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Preoperative Haematologic Markers for the Differentiation of Endometrial Cancer from Benign Endometrial Lesions in Postmenopausal Patients with Endometrial Masses Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-06 Yong Jung Song, Hwi Gon Kim, Hyung Joon Yoon, Kyung Un Choi, Dong Soo Suh, Ki Hyung Kim
Purpose: The diagnostic value of preoperative hematological changes in endometrial cancer (EC) remains unclear. This study aimed to assess the role of preoperative hematologic parameters in differentiating EC from benign endometrial lesions in postmenopausal women with endometrial masses. Methods: Preoperative laboratory variables were retrospectively reviewed in patients with malignant or benign endometrial
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Construction of a Prognostic Model Based on Methylation-Related Genes in Patients with Colon Adenocarcinoma Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-05 ZhenDong Liu, YuYang Xu, Shan Jin, Xin Liu, BaoChun Wang
Purpose: Colon adenocarcinoma (COAD) is the second leading cause of death in the world, and the new incidence rate ranks third among all cancers. Abnormal DNA methylation is related to the occurrence and development of tumors. In this study, we aimed to identify genes associated with abnormal methylation in COAD. Methods: COAD transcriptome data, methylation data and clinical information were downloaded
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Treatment Outcomes and Prognostic Factors in N3 Stage Gastric Cancer After Curative Resection: A Real World Data Cancer Manage. Res. (IF 3.3) Pub Date : 2023-10-03 Eda Caliskan Yildirim, Yusuf Acikgoz, Yakup Ergun, Efnan Algin, Oznur Bal
Purpose: N3 gastric cancer is characterized by a fairly high lymph node metastasis burden and poor outcome despite optimal therapy. Given the limitations of TNM classification, a comprehensive evaluation tool is necessary to predict the prognosis of patients with N3 gastric cancer who underwent curative surgery. This study aims to explore the outcomes and clinicopathologic prognostic factors affecting
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A New Scoring System for Predicting Mortality in Hematological Malignancies with Sepsis: A Derivation and Validation Study Cancer Manage. Res. (IF 3.3) Pub Date : 2023-09-29 Haitao Li, Shengjin Fan, Dongxue Lu, Jin Zhou
Objective: This study aimed to derive and validate a prognostic scoring system to identify patients with hematological malignancies (HMs) and sepsis who have a high mortality rate. Methods: Cohorts for derivation and validation were created from all data. Using univariate and multivariate analysis, the independent variables connected to 28-day mortality in the derivation cohort were found. A receiver
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Therapeutic Potential of Tisotumab Vedotin in the Treatment of Recurrent or Metastatic Cervical Cancer: A Short Report on the Emerging Data Cancer Manage. Res. (IF 3.3) Pub Date : 2023-09-27 Veronica Agostinelli, Lucia Musacchio, Floriana Camarda, Vanda Salutari, Maria Vittoria Carbone, Viola Ghizzoni, Camilla Nero, Caterina Ricci, Maria Teresa Perri, Elena Giudice, Sara Lardino, Rossana Berardi, Giovanni Scambia, Domenica Lorusso
Abstract: Cervical cancer is the fourth most common type of cancer in women worldwide. It is associated with a high death rate, despite the fact that it is a nearly 100% preventable disease because of very effective primary and secondary preventive strategies. Advanced and recurrent disease is uncurable with a high relapse risk and the second-line therapies are limited with modest response rates and
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Development and Validation of a Novel Diagnostic Nomogram Model Using Serum Oxidative Stress Markers and AURKA for Prediction of Nasopharyngeal Carcinoma Cancer Manage. Res. (IF 3.3) Pub Date : 2023-09-27 Jiahui Wu, Huidan Luo, Kun Wang, Bin Yi
Purpose: The mortality rate of nasopharyngeal carcinoma (NPC) remains high due to the absence of quick and accurate diagnostic approaches at its early stage. Our aim is to evaluate the diagnostic value of the elevated expression of Aurora kinase A (AURKA) and the oxidative stress markers (such as glutathione, superoxide dismutase and malondialdehyde) in serum of NPC patients and to establish a nomogram
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Primary Breast Burkitt Lymphoma. A Case Report of a 16-Year-Old Female with a Rapidly Growing Unilateral Breast Mass Cancer Manage. Res. (IF 3.3) Pub Date : 2023-09-26 Yekosani Mitala, Brian Ssenkumba, Rita Nabulya, Francis Nsumba Kitenda, Habert Tumwesigye, Abraham Birungi, Richard Dratu Chau, Branchard Mushabe, Nichole Baker, Raymond Atwine
Introduction: Primary breast Burkitt lymphoma is extremely rare. Commonly endemic Burkitt lymphoma presents with abdominal, jaw, periorbital, or genitourinary mass. Case Presentation: We report a case of a 16-year-old girl with rapidly enlarging left breast swelling associated with evening fevers. This was later confirmed to be stage 1 primary breast Burkitt lymphoma involving the left breast. This
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The Incidence and Management of Cancer-Related Anorexia During Treatment with Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors Cancer Manage. Res. (IF 3.3) Pub Date : 2023-09-22 Shunji Takahashi, Koji Matsumoto, Kojiro Ohba, Yasuhiro Nakano, Yasushi Miyazawa, Takumi Kawaguchi
Abstract: Cancer-related anorexia is a common complication and frequently occurs in cancer patients treated with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs). Anorexia contributes to malnutrition, body weight loss, and cachexia in affected patients. Furthermore, patients who experience anorexia have worse outcomes than those who maintain their appetite, highlighting