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The Effectiveness of P6 and Auricular Acupressure as a Complimentary Therapy in Chemotherapy-Induced Nausea and Vomiting Among Patients With Cancer: Systematic Review Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-15 Bushra Alhusamiah, Jumana Almomani, Ahmad Al Omari, Ala’a Abu attallah, Afaf Yousef, Jafar Alasad Alshraideh, Ruqayya S. Zeilani
Background:Chemotherapy-induced nausea and vomiting (CINV) is one of the most prevalent and distressing side effects of chemotherapy among patients with cancer worldwide. Despite continuing advances in antiemetic medicines, nausea and vomiting associated with cancer chemotherapy remain a substantial therapeutic concern for many patients. However, P6 and Auricular acupressure (AA) have been recognized
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Efficacy and Safety of Huachansu as an Adjuvant Therapy for Non-Small Cell Lung Cancer: An Overview of Systematic Reviews and Meta-Analyses Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-12 Tiantian Yang, Caixian Wu, Peicong Li, Yuetong Zhong, Wanyin Wu, Sumei Wang, Xiaobing Yang
Objective:The purpose of this overview is to assess systematic reviews (SRs)/ meta-analyses (MAs) of Huachansu (HCS) combination chemotherapy for treating non-small cell lung cancer (NSCLC) and provide summarized evidence for clinical decision making.Methods:From the creation of the database to JUNE 2023, 8 databases in English and Chinese were searched. SRs/MAs that met the inclusion and exclusion
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Genome-wide Analysis Identified SEMA4D, Novel Candidate Gene for Temperature Sensitivity in Patients With Non-Small Cell Lung Cancer Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-12 Jung-Hyang Park, Eunbin Kwag, Mi-Kyung Jeong, So-Jung Park, Sanghun Lee, Hwa-Seung Yoo
Background:In the era of precision medicine, individual temperature sensitivity has been highlighted. This trait has traditionally been used for cold-heat pattern identification to understand the inherent physical characteristics, which are influenced by genetic factors, of an individual. However, genome-wide association studies (GWASs) on this trait are limited.Methods:Using genotype data from 90
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Integration of Network Pharmacology and Experimental Validation to Explore Jixueteng - Yinyanghuo Herb Pair Alleviate Cisplatin-Induced Myelosuppression Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-11 Yi Liu, Shuying Dai, Yixiao Xu, Yuying Xiang, Yao Zhang, Zeting Xu, Lin Sun, Gao-chen-xi Zhang, Qijin Shu
Jixueteng, the vine of the bush Spatholobus suberectus Dunn., is widely used to treat irregular menstruation and arthralgia. Yinyanghuo, the aboveground part of the plant Epimedium brevicornum Maxim., has the function of warming the kidney to invigorate yang. This research aimed to investigate the effects and mechanisms of the Jixueteng and Yinyanghuo herbal pair (JYHP) on cisplatin-induced myelosuppression
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Anti-proliferative Effects of Pinocembrin Isolated From Anomianthus dulcis on Hepatocellular Carcinoma Cells Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-11 Charupong Saengboonmee, Kanyarat Thithuan, Panupong Mahalapbutr, Cheerapinya Taebprakhon, Aamir Aman, Thanyada Rungrotmongkol, Anyanee Kamkaew, Florian Thierry Schevenels, Tanakiat Chompupong, Sopit Wongkham, Ratsami Lekphrom
Background:Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Anomianthus dulcis (Dunal) J.Sinclair (syn. Uvaria dulcis) has been used in Thai traditional medicine in various therapeutic indications. Phytochemical constituents of A. dulcis have been isolated and identified. However, their effects on liver cancer and the associated mechanisms have not been elucidated.Methods:Dry
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Deciphering the Mechanism of Siwu Decoction Inhibiting Liver Metastasis by Integrating Network Pharmacology and In Vivo Experimental Validation Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-11 Xuelei Chu, Feiyu Xie, Chengzhi Hou, Xin Zhang, Sijia Wang, Hongting Xie, Chen An, Ying Li, Leyi Zhao, Peng Xue, Shijie Zhu
Background:Siwu Decoction (SWD) is a well-known classical TCM formula that has been shown to be effective as a basis for preventing and reducing liver metastases (LM). However, the active ingredients and potential molecular mechanisms remain unclear.Objective:This study aimed to systematically analyze the active ingredients and potential molecular mechanisms of SWD on LM and validate mechanisms involved
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Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023 Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-06 Ali Kudamba, Josephine N. Kasolo, Godfrey S. Bbosa, Allan Lugaajju, Henry Wabinga, Hussein M. Kafeero, Jamilu E. Ssenku, Shaban O. Alemu, Abdul Walusansa, Nixon Niyonzima, Haruna Muwonge
Background:In the East African region, herbal plants are essential in the treatment and control of cancer. Given the diverse ecological and cultural makeup of the regional states, it is likely that different ethnic groups will use the same or different plants for the same or different diseases. However, since 2019, this has not been compiled into a single study.Purpose:The study aimed to compile and
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Effect of Preoperative Lifestyle Management and Prehabilitation on Postoperative Capability of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-05 JiaJun Zhang, YuRu Hu, HuiLi Deng, ZhongMou Huang, JianMei Huang, Qu Shen
Background:The surgical intervention serves as the paramount and prevalent remedy for individuals afflicted with colorectal malignancies, with the significance of perioperative stewardship and convalescence being indisputable. Prehabilitation coupled with preoperative lifestyle modulation has demonstrated efficacy in patients subjected to certain classifications of abdominal procedures. However, the
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Bojungikgi-tang for Chemotherapy-induced Leukopenia: A Systematic Review and Meta-Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-01 Lib Ahn, Song Won Park, Dong-jun Choi
Chemotherapy-induced leukopenia is a common side effect of cytotoxic anticancer drugs. It can deprive patients of treatment opportunities, resulting in the delay, reduction, or discontinuation of chemotherapy or other anticancer drug administration. Two researchers searched English, Chinese, Japanese, and Korean electronic databases, without limiting the time period and language, using search terms
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Evaluating the Feasibility and Acceptability of a Psychosexual Intervention for Couples Post-allogeneic Hematopoietic Stem Cell Transplantation Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-03-01 Brindha Pillay, David Ritchie, Yvonne Panek-Hudson, Michael Jefford, Teresa Garcia, Cassandra Shields, Jo Gniel, Jo Phipps-Nelson, Allison Drosdowsky, Steve Ellen, Maria Ftanou
Purpose:Allogeneic hematopoietic stem cell transplantation (HSCT) can have a long-term impact on patients’ sexual functioning and consequently, their relationship satisfaction. This study aimed to examine the feasibility and acceptability of a 5-session psychosexual intervention for HSCT survivors and their partners.Methods:To be eligible patients were required to be more than 3 months post-allogeneic
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Hu-Qi-Zheng-Xiao Decoction Inhibits the Metastasis of Hepatocellular Carcinoma Cells by Suppressing the HIF-1α Signaling Pathway to Inhibit EMT, LCSC, and Angiogenic Process Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-22 Xuejing Wang, Ling Yin, Mengyin Chai, Buxin Kou, Xiaoni Liu, Xiaojun Wang
Background:Hepatocellular carcinoma (HCC) is a common clinical malignant tumor of the digestive system. Hu-Qi-Zheng-Xiao (HQZX) decoction has been clinically found to prolong the survival of patients with hepatocellular carcinoma and improve the quality of patients’ survival, but its antitumor biological mechanism is still unclear.Methods:A nude mouse hollow fiber hepatocellular carcinoma model was
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Yoga Therapy as an Intervention to Improve Patient-Reported Outcomes Among Adults After Treatment for Cancer: Preliminary Findings From a Trial Using Single-Subject Experimental Design Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-22 Jennifer Brunet, Julia Hussien, Anne Pitman, Amanda Wurz, Ellen Conte, Nadia Polskaia, Dugald Seely
Background:Cancer is a chronic condition associated with a substantial symptom burden, which can impair recovery after treatment. Investigating interventions with potential to improve self-reported disease and/or treatment effects—known as patient-reported outcomes (PROs)—is paramount to inform cancer care. The objective of this study was to evaluate the effects of a yoga therapy (YT) intervention
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The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-19 Yi Zhao, Linan Zhao, Tao Wang, Zhenghao Liu, Suyuan Tang, Hongxia Huang, Li Wu, Youzhi Sun
Background:Soothing the liver (called Shu Gan Jie Yu in Chinese, SGJY) is a significant therapeutic method for breast cancer in TCM. In this study, 3 liver-soothing herbs, including Cyperus rotundus L., Citrus medica L. var. sarcodactylis Swingle and Rosa rugosa Thunb. were selected and combined to form a SGJY herbal combinatory.The Aim of the Study:To investigate the inhibiting effect of SGJY on breast
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Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-19 Hye-Ri Bae, Eun-Ji Kim, Yo-Chan Ahn, Jung-Hyo Cho, Chang-Gue Son, Nam-Hun Lee
Introduction:Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a systematic review and meta-analysis to compare the differences in fatigue scale scores, quality of life,
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Prevention of Bladder Cancer Recurrence With the Botanical Formula LCS103: A Case Series Study Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-16 Yair Maimon, Gilad Amiel, Zoya Cohen, Azik Hoffman, Noah Samuels
Despite effective chemotherapy and other available oncology treatments, recurrence rates for non-muscle invasive bladder cancer (NMIBC) remain high, with as many as 60% of patients requiring repeat intravesical treatments with BCG or other agents within a 24-month period. The botanical formula LCS103 has displayed anti-cancer activity on bladder cancer cells, though its clinical efficacy remains to
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Effects of Traditional Chinese Medicine “Fuzheng Qingdu Decoction” on Autonomic Function and Cancer-Related Symptoms in Patients with Advanced Gastric Cancer undergoing Chemotherapy: A Controlled Trial Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-07 Chengjia Yuan, Shuang Wu, Yang Wu, Cuiling Tian, Zaichuan Wang, Xiaochun Zhang
Objective:To evaluate the effects of Fuzheng Qingdu Decoction (FZQDD) on the autonomic function and cancer-related symptoms of patients with advanced gastric cancer undergoing chemotherapy to verify its clinical efficacy.Methods:Sixty-two patients with stage III or IV gastric cancer were included in this study. The patients were divided into 2 groups: the chemotherapy (33 patients) and chemotherapy
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Baduanjin Mind-Body Exercise for Cancer-Related Fatigue: Protocol for a Remotely Delivered Randomized Wait-List Controlled Feasibility Study Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-02-06 Sean Walsh, Kang Wang, Anderson Lam, Shihao Du, Yanbin Hu, Yu-Ting Sun, Elise Tcharkhedian, Evangeline Nikas, Gregory Webb, Eugene Moylan, Stephen Della-Fiorentina, Paul Fahey, Xin Shelley Wang, Ming Chen, Xiaoshu Zhu
Background:People living with a cancer diagnosis often experience cancer-related fatigue (CRF). Between 9% and 45% of people report CRF as moderate to severe, negatively impacting their quality-of-life (QOL). The evidence-base for managing CRF recommends exercise-related therapies over pharmaceutical interventions. One such exercise-like therapy is Baduanjin mind-body exercise (MBE), which has additional
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Pharmacokinetic Analysis of Prognostic Factors in Patients With Advanced-Stage Intrahepatic Cholangiocarcinoma Following the Administration of Capsule Formulation of the Standardized Extract of Atractylodes lancea (Thunb) DC Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-31 Teerachat Saeheng, Juntra Karbwang, Anurak Cheomung, Nisit Tongsiri, Tullayakorn Plengsuriyakarn, Kesara Na-Bangchang
Background:A statistical model is essential in determining the appropriate predictive indicators for therapies in many types of cancers. Predictors have been compared favorably to the traditional systems for many cancers. Thus, this study has been proposed as a new standard approach. A recent study on the clinical efficacy of Atractylodes lancea (Thunb) DC. (AL) revealed the higher clinical benefits
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Are Published Cancer Care Trial Protocols With Traditional Chinese Medicine Interventions Concordant With SPIRIT-TCM Extension 2018? A Scoping Review on Published Trial Protocols Between 2019 and 2022 Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-31 Hezheng Lai, Peiying Yang, Xin Shelley Wang, David Lim, Anderson Lam, Yucong Shi, Yishi Huang, Xiaoshu Zhu
Background:The SPIRIT-TCM Extension 2018 was created to guide the design and reporting of Traditional Chinese Medicine (TCM) clinical trial protocols. This study aims to investigate the extent of concordance with this guideline in the relevant field of cancer care research.Methods:A scoping review of TCM cancer trial protocols published in English and Chinese since January 2019 was conducted. Five
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Characteristics and Challenges of Providing Acupuncture and Chinese Herbal Medicine in Oncology Treatment: Report of Survey Data and Experience of Five Unique Clinical Settings Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-30 Susan Veleber, Misha Ruth Cohen, Matthew Weitzman, Yair Maimon, Christine A. Adamo, Jonathan Siman, Weidong Lu, Tammy Sajdyk, Jennifer A.M. Stone
Acupuncture is an integrative therapy with strong evidence to support its use in the oncology setting, yet barriers exist for implementation into conventional medical clinics. Though acupuncture is recommended in clinical practice guidelines for oncology, there is little data in the literature showing how acupuncture and other related therapies, including herbal medicine are successfully implemented
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Feasibility and Usability of EnergyPoints: A Mobile Health App to Guide Acupressure Use for Cancer Symptom Management Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-29 Susan L. Beck, Ryan Smith, Janet Mindes, Karl Beck, JungYoon Leah Kim, Matthew Weitzman, Jennifer A. M. Stone, Susan Veleber, William N. Dudley
Objective:To examine the feasibility and usability of EnergyPoints™, an innovative mobile health app that teaches and guides people with cancer to implement daily acupressure to self-manage their fatigue and sleep disturbances.Methods and Intervention:The study used an integrated agile, human-centered approach. Adults (age 18 years and over) with cancer experiencing at least moderate fatigue, and living
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Comprehensive Evaluation of Traditional Herbal Medicine Combined With Adjuvant Chemotherapy on Post-Surgical Gastric Cancer: A Systematic Review and Meta-Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-28 Soo-Dam Kim, Jong-Hee Kim, Dong-Hyun Kim, Ji-Hye Park, Yabin Gong, Chengbing Sun, Hwa-Seung Yoo, So-Jung Park
Background:Gastric cancer is a common cause of global mortality, with significant challenges during treatment due to side effects and complications. Traditional herbal medicine (THM) has emerged as a potential adjuvant therapy to enhance cancer treatment by reducing side effects and bolstering the immune response. This study conducted a meta-analysis to assess the efficacy and safety of THM as an adjuvant
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Initiating and Maintaining Complete Decongestive Therapy Self-Management of Lymphedema Among Breast Cancer Survivors: Descriptive Qualitative Study Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-28 Yuanlu Sun, Mei Rosemary Fu, Yun Jiang, Amy S. Little
Purpose:This study aimed to identify determinants that promote the initiation and maintenance of complete decongestive therapy (CDT) as well as effective strategies for mitigating barriers to self-management of lymphedema among breast cancer survivors.Methods:A descriptive and qualitative design was used. In-depth interviews were conducted with 13 breast cancer survivors who were managing breast cancer-related
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Study of Drug Targets Associated With Oncogenesis and Cancer Cell Survival and the Therapeutic Activity of Engineered Ashwagandha Extract Having Differential Withanolide Constitutions Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-28 Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee
Ashwagandha ( Withania somnifera) has gained worldwide popularity for a multitude of health benefits inclusive of cancer-preventive and curative effects. Despite numerous research data supporting the benefits of this wonder herb, the actual use of ashwagandha for cancer treatment in clinics is limited. The primary reason for this is the inconsistent therapeutic outcome due to highly variable composition
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Ozone Therapy for Breast Cancer: An Integrative Literature Review Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-23 Yanchu Li, Rong Pu
Breast cancer is the most prevalent form of cancer in women. Despite significant advances in conventional treatment, additional safer complementary treatment options are needed. Recently, ozone therapy has been considered as a type of medical adjunctive treatment that could inhibit cancer cell survival and reduce chemoresistance. However, only a few studies have been conducted on its use in breast
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Implementation of Virtual Integrative Oncology Shared Medical Appointment Series (VIOSMAS) Within Mixed Diagnosis Population Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-20 Michelle H. Loy, Lauren Prisco, Chiti Parikh
Background:Integrative oncology [IO] is sought-after by patients, endorsed by clinical guidelines, and valued within National Cancer Institute Centers. Shared Medical Appointments [SMA] leverage health education and social connection to deliver enhanced patient experience, population health, cost-reduction, and clinician well-being. Integrative Oncology Shared Medical Appointments increase access to
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Potential Efficacy of Shiunko for Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody-Induced Skin Fissure: A Single Institutional Case Series Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-19 Mashiro Okunaka, Daisuke Kotani, Saori Mishima, Maho Nakamura, Akihito Kawazoe, Hideaki Bando, Takayuki Yoshino, Kohei Shitara
Purpose:Anti-epidermal growth factor receptor monoclonal antibody (anti-EGFR mAb) is the key drug for RAS/ BRAF V600E wild-type metastatic colorectal cancer (mCRC). However, anti-EGFR mAb-induced skin fissures often affect a patient’s quality of life. Shiunko, a traditional Japanese topical herbal medicine, is used for burns and dermatitis and may potentially have wound-healing effects. Herein, we
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Clinical Experience of External Application of Clearing Heat and Removing Dampness in Relieving Grade 2 to 3 Rash Caused by Programed Cell Death Protein 1 (PD-1)/Programed Cell Death Ligand 1 (PD-L1) Inhibitors: A Single-Center Retrospective Study Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-19 Shu-yi Chen, Fang-min Zhao, Rui Yu, Lin Sun, Yu-dan Yin, Gao-chen-xi Zhang, Jia-yao Yang, Qi-jin Shu
Objective:In China, grade 2 to 3 immune-related rash will probably lead to the interruption of immunotherapy. Corticosteroid (CS) is the main treatment, but not always effective. The external application of clearing heat and removing dampness, which is represented by Qing-Re-Li-Shi Formula (QRLSF), has been used in our hospital to treat immune-related cutaneous adverse events (ircAEs) for the last
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Efficacy and Safety of Traditional Chinese Medicines as a Complementary Therapy Combined With Chemotherapy in the Treatment of Gastric Cancer: An Overview of Systematic Reviews and Meta-Analyses Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-17 Weijian Xie, Yunsong Zhang, Jingyun Tang, Xiaolin Zhu, Shijun Wang, Meiqi Lu
Background:In China, traditional Chinese medicines (TCMs), as a complementary therapy combined with chemotherapy, is widely used in the treatment of gastric cancer (GC). In order to systematically evaluate and synthesize existing evidence to provide a scientific basis for the efficacy and safety of this complementary therapy, we present an overview of systematic reviews (SRs) and meta-analyses (MAs)
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A Prospective Multi-Centered Registry-Based Observational Study for Patients With Cancer: Design and Rationale for Korean Medicine Cancer Registry (KMCARE) Integr. Cancer Ther. (IF 2.9) Pub Date : 2024-01-05 Jee Young Lee, Hayun Jin, Su Bin Park, Eun Hye Kim, Jee-Hyun Yoon, Seong Woo Yoon
Background:Cancer is one of the leading causes of death in most countries with an expected increased burden on healthcare systems. Since integrative medical treatments are not collected within the scope of existing cancer registries, the establishment of the Korean Medicine Cancer Registry (KMCARE), gathering integrative therapies, including conservative care and Korean medicine, is warranted.Methods:A
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Comparing the Effects of Warm Footbath and Foot Reflexology on the Fatigue of Patients Undergoing Radiotherapy: A Randomized Clinical Trial Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-05-10 Seyed Reza Mazloum, Mahla Rajabzadeh, Samira Mohajer, Hamidreza Bahrami-Taghanaki, Mohammad Namazinia
Background and Aim:Fatigue is a common side effect of radiotherapy. While warm footbath and foot reflexology can both reduce fatigue, it is still unclear which method is more effective in reducing ...
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6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-05-09 Min Chen, Chiin Tong, Qibiao Wu, Zhenghong Zhong, Qida He, Li Zeng, Lu Xiao
6-Shogaol from ginger has anti-inflammatory, anti-oxidation and anti-cancer effects. Aim of the Study: To study the effects and possible mechanisms of 6-Shogaol on inhibiting the migration of colon...
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A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-05-04 Abdolazim Sedighi Pashaki, Fateme Sheida, Leila Moaddab Shoar, Tahereh Hashem, Danial Fazilat-Panah, Alireza Nemati Motehaver, Ali Ghanbari Motlagh, Safoora Nikzad, Mojtaba Bakhtiari, Leili Tapak, Zahir Keshtpour Amlashi, Seyed Alireza Javadinia, Zahra Keshtpour Amlashi
Objective:Cancer related fatigue is a distressing condition and correlated with decrease in quality of life of patients with malignant conditions. In continuation of our previous research, we asses...
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Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-05-03 Yingchao Wu, Dajin Pi, Shuyao Zhou, Wuhong Wang, Huan Ye, Zhongjia Yi, Yiliu Chen, Mingzi Ouyang
Background:Cisplatin is a widely used anticancer drug in clinic, but it has a damaging effect on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had a alleviating ...
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The Efficacy and Safety of the Shouzu Ning Decoction Treatment Versus Halometasone Plus Celecoxib Treatment in Patients With Grade 2 HFSR: A Randomized Clinical Trial Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-20 Liumei Shou, Tianyu Shao, Jialu Chen, Yao Zhang, Qijin Shu
Objectives:To compare the effects of the Shouzu Ning Decoction (SND) and Halometasone plus Celecoxib (Hal/Cxb) as therapy in patients with grade 2 hand-foot skin reaction (HFSR).Materials and Metho...
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Babao Dan Alleviates Cancer Cachexia in Mice Via Inhibiting IL-6/STAT3 Signaling Pathway Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-19 Zhengliang Qiu, Da Wo, Xiaomei Zhong, Jinxiao Chen, En Ma, Jia He, Jun Peng, Weidong Zhu, Dan-ni Ren
Background:Cancer cachexia is a common but severe condition that causes muscle wasting, body weight loss, and progressive functional impairment, affecting over 50% of cancer patients. Currently, th...
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Dose Delays, Dose Reductions, and Relative Total Dose Intensity in Patients With Advanced Cancer Who Exercised During Neoadjuvant Chemotherapy Treatment Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-19 Karen Y. Wonders, Kathryn Schmitz, Jay Harness
Background:When it comes to chemotherapy, maintaining the dose and schedule of treatment are of vital importance, as clinical evidence suggests that dose intensity is associated with optimal treatm...
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Effects of Traditional Chinese Medicine Injections for Anthracyclines-induced Cardiotoxicity: An Overview of Systematic Reviews and Meta-Analyses Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-13 Chenchen Li, Yuling Zheng, Dong Niu, Ranpei Zhu, Xiaoyu Yan, Haoran Qu, Yaling Zhang
Introduction:Traditional Chinese medicine (TCM) injections, as a relatively safe and low-cost treatment, have been widely used in the prevention and treatment of anthracyclines-induced cardiotoxici...
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Effects of Traditional Chinese Medicine Injections for Anthracyclines-induced Cardiotoxicity: An Overview of Systematic Reviews and Meta-Analyses. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Chenchen Li,Yuling Zheng,Dong Niu,Ranpei Zhu,Xiaoyu Yan,Haoran Qu,Yaling Zhang
INTRODUCTION Traditional Chinese medicine (TCM) injections, as a relatively safe and low-cost treatment, have been widely used in the prevention and treatment of anthracyclines-induced cardiotoxicity in China. However, the quality of the relevant systematic reviews and meta-analyses published in recent years is uneven, so that the effectiveness and safety of TCM injections in preventing and treating
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Effect of Chamomile on the Complications of Cancer: A Systematic Review Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-13 Maryam Maleki, Abbas Mardani, Mehdi Manouchehri, Mansoureh Ashghali Farahani, Mojtaba Vaismoradi, Manela Glarcher
Background and objectives:Despite significant advances in the diagnosis and treatment of cancer, many people across the world still suffer from this chronic disease and its complications. Chamomile...
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In Regard to Faravel et al. 2022: "Trismus Occurrence and Link With Radiotherapy Doses in Head and Neck Cancer Patients Treated With Chemoradiotherapy". Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Efsun Somay,Busra Yilmaz,Erkan Topkan
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Response to Somay et al. Letter to the Editor Regarding "Trismus Occurrence and Link With Radiotherapy Doses in Head and Neck Cancer Patients Treated With Chemoradiotherapy". Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Kerstin Faravel,Marta Jarlier,Pierre Senesse,Marie-Eve Huteau,Chloé Janiszewski,Anne Stoebner,Pierre Boisselier
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Reducing Anxiety and Dyspnea via Device-Guided Breathing (RELAX): A Multi-Site Feasibility Study in Post-Treatment Lung Cancer Survivors at Community Cancer Clinics (WF-01213) Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-08 Suzanne C. Danhauer, Emily V. Dressler, W. Mark Brown, Chandylen L. Nightingale, Gretchen A. Brenes, William J. Petty, Amarinthia Curtis, Srujitha Murkutla, Jocelin Huang, Cheyenne R. Wagi, Glenn J. Lesser, Kathryn E. Weaver
Introduction:Anxiety and dyspnea are 2 common symptoms for lung cancer survivors. Although research suggests decreasing respiration rate can reduce anxiety in several populations, potential benefit...
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Extract of Platycodon grandiflorum Prevents Doxorubicin-induced Cardiotoxicity in Breast Cancer Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-08 Youyang Shi, Yuanyuan Wu, Man Shen, Jianfeng Yang, Yuenong Qin, Sheng Liu, Chenping Sun
Doxorubicin (Dox) is a first-line chemotherapeutic agent applied in cancer treatment. Its long-term anticancer efficacy is restricted mainly due to its subsequent cardiotoxicity for patients. Platy...
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Perspectives and Attitudes of Dutch Healthcare Professionals Regarding the Integration of Complementary Medicine in Oncology Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-07 Aniek E.M. Schouten, Marit D.C. Mentink, Johanna (Anja) N.H. Timmer-Bonte, Janneke Noordman, Sandra van Dulmen
Introduction:Almost half of all patients with cancer use complementary medicine (CM) alongside conventional cancer treatment. Further integration of CM into clinical practice could enhance communic...
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Reducing Anxiety and Dyspnea via Device-Guided Breathing (RELAX): A Multi-Site Feasibility Study in Post-Treatment Lung Cancer Survivors at Community Cancer Clinics (WF-01213). Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Suzanne C Danhauer,Emily V Dressler,W Mark Brown,Chandylen L Nightingale,Gretchen A Brenes,William J Petty,Amarinthia Curtis,Srujitha Murkutla,Jocelin Huang,Cheyenne R Wagi,Glenn J Lesser,Kathryn E Weaver
INTRODUCTION Anxiety and dyspnea are 2 common symptoms for lung cancer survivors. Although research suggests decreasing respiration rate can reduce anxiety in several populations, potential benefits of device-guided breathing have not been studied in lung cancer survivors. This feasibility study (WF-01213) provides estimates of accrual, adherence, retention, and preliminary efficacy of 2 doses of a
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Extract of Platycodon grandiflorum Prevents Doxorubicin-induced Cardiotoxicity in Breast Cancer. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Youyang Shi,Yuanyuan Wu,Man Shen,Jianfeng Yang,Yuenong Qin,Sheng Liu,Chenping Sun
Doxorubicin (Dox) is a first-line chemotherapeutic agent applied in cancer treatment. Its long-term anticancer efficacy is restricted mainly due to its subsequent cardiotoxicity for patients. Platycodon grandiflorum (PG), an important traditional Chinese herb, has been reported to eliminate phlegm, relieve cough, and reduce inflammatory diseases. Previous clinical studies found that PG has cardioprotective
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Perspectives and Attitudes of Dutch Healthcare Professionals Regarding the Integration of Complementary Medicine in Oncology. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Aniek E M Schouten,Marit D C Mentink,Johanna Anja N H Timmer-Bonte,Janneke Noordman,Sandra van Dulmen
INTRODUCTION Almost half of all patients with cancer use complementary medicine (CM) alongside conventional cancer treatment. Further integration of CM into clinical practice could enhance communication and ensure improved coordination between complementary medicine and conventional care. This study assessed the perspectives of healthcare professionals on the current status of integration of CM in
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The Herbal Medicine Suanzaoren (Ziziphi Spinosae Semen) for Sleep Quality Improvements: A Systematic Review and Meta-analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-04-04 Mingxiao Yang, Hui Wang, Yi Lily Zhang, Furong Zhang, Xiaotong Li, Soo-Dam Kim, Yalan Chen, Jiyao Chen, Susan Chimonas, Deborah Korenstein, Jun J. Mao
Background:Sleep disturbances are common and bothersome among cancer and noncancer populations. Suanzaoren (Ziziphi Spinosae Semen) is commonly used to improve sleep, yet its efficacy and safety ar...
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Assessing the Relationship Between Liver Metastases and the Survival of Patients With Non-Small Cell Lung Cancer After Immune Checkpoint Inhibitors Treatment: A Systematic Review and Meta-Analysis Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-03-30 Huilin Xu, Pingpo Ming, Zhenyu Zhao, Nan Zhao, Dingjie Zhou, Xixian Tang, Dedong Cao
Objective:It is not well determined whether liver metastasis is a prognostic factor for survival of metastatic non-small cell lung cancer (NSCLC) patients who received immune checkpoint inhibitors ...
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The Close Relationship Between Metabolic Syndrome and Hormone Receptor-Positive Early-Stage Breast Cancer Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-03-28 Ahmet Ozveren, Melis Ridvanogullari Donger, Sedat Motor, Gulcan Bulut
Objective:The primary aim of the current study was to investigate the frequency of metabolic syndrome (MS) in early-stage breast cancer patients. Additionally, clinicopathological factors, such as ...
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Characterization of Oral Microbiota Following Chemotherapy in Patients With Hematopoietic Malignancies Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-03-15 Michi Omori, Nahoko Kato-Kogoe, Shoichi Sakaguchi, Eri Komori, Kazuya Inoue, Kayoko Yamamoto, Wataru Hamada, Tomoyoshi Hayase, Tomoyuki Tano, Shota Nakamura, Takashi Nakano, Hidenori Une, Takaaki Ueno
Oral microbiota may be associated with serious local or systemic medical conditions resulting from chemotherapy. This study was conducted to evaluate the changes in the oral microbiota following th...
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A Review of The Synergistic Effects of Curcumin with Proteasome Inhibitors in Multiple Myeloma Preclinical Models Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-03-06 Shaunak K. Pandya, Arati Pandya, Ashley Larsen, Krisstina Gowin
Proteasome inhibitors are the cornerstone of multiple myeloma treatment, but challenges still remain despite the increased survival rates. We conducted a review on the role of curcumin, a natural p...
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Ginkgo biloba Golden Leaf Extract (GGLE) Inhibits Melanoma Cell Invasion and Angiogenesis Through Inhibition of Angiogenin. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Ping Chen,Tao Wang,Qi Chen
The popular dietary supplements of Ginkgo biloba (Ginkgo) products have been reported to have anti-cancer activities in multiple cellular and animal studies, with the benefits yet to be proven with clinical trials. The mechanisms of action are not clear, forming a barrier to investigation in Gingko-specific benefits to cancer patients, especially when combined with other therapies. Here we reported
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Ginkgo biloba Golden Leaf Extract (GGLE) Inhibits Melanoma Cell Invasion and Angiogenesis Through Inhibition of Angiogenin Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-03-01 Ping Chen, Tao Wang, Qi Chen
The popular dietary supplements of Ginkgo biloba (Ginkgo) products have been reported to have anti-cancer activities in multiple cellular and animal studies, with the benefits yet to be proven with...
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Effects of a Video Sequence Based Intervention on Anxiety, Fatigue and Depression in Cancer Patients: Results of a Randomized Controlled Trial Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-02-17 Sven Neubert, Sina Schlecht, Karin Meng, Antonia Rabe, Elisabeth Jentschke
Background:Cancer patients often suffer from psychological symptoms and need psychological support. Especially during the COVID-19 pandemic, eHealth interventions might be helpful to overcome the o...
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The Role of Ketogenic Diet in the Treatment of Neuroblastoma Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-02-08 Rangarirai Makuku, Zeinab Sinaei Far, Neda Khalili, Alistar Moyo, Sepideh Razi, Mahsa Keshavarz-Fathi, Maryam Mahmoudi, Nima Rezaei
The ketogenic diet (KD) was initially used in 1920 for drug-resistant epileptic patients. From this point onward, ketogenic diets became a pivotal part of nutritional therapy research. To date, KD ...
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The Role of Ketogenic Diet in the Treatment of Neuroblastoma. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Rangarirai Makuku,Zeinab Sinaei Far,Neda Khalili,Alistar Moyo,Sepideh Razi,Mahsa Keshavarz-Fathi,Maryam Mahmoudi,Nima Rezaei
The ketogenic diet (KD) was initially used in 1920 for drug-resistant epileptic patients. From this point onward, ketogenic diets became a pivotal part of nutritional therapy research. To date, KD has shown therapeutic potential in many pathologies such as Alzheimer's disease, Parkinson's disease, autism, brain cancers, and multiple sclerosis. Although KD is now an adjuvant therapy for certain diseases
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Long-Term Complete Remission of a Patient With Double-Hit Diffuse Large B-Cell Lymphoma Treated by Chemoimmunotherapy and Chinese Herbal Medicine. Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-01-01 Henry Liang,Jessica Guo,Chun Guang Li
Double-hit diffuse large B-cell lymphoma (DHL) is an uncommon subtype of lymphoma which poorly responds to current drug therapies and has low rates of long-term survival in the patients. Herein, we report a case of a 73-year-old Caucasian male who was diagnosed with DHL with double-hit mutations of rearrangement of both c-MYC and BCL2 in November 2013. He commenced the standard R-CHOP-14 chemotherapy
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Long-Term Complete Remission of a Patient With Double-Hit Diffuse Large B-Cell Lymphoma Treated by Chemoimmunotherapy and Chinese Herbal Medicine Integr. Cancer Ther. (IF 2.9) Pub Date : 2023-02-01 Henry Liang, Jessica Guo, Chun Guang Li
Double-hit diffuse large B-cell lymphoma (DHL) is an uncommon subtype of lymphoma which poorly responds to current drug therapies and has low rates of long-term survival in the patients. Herein, we...