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Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors Leukemia (IF 11.4) Pub Date : 2024-03-16 T. Jelinek, D. Zihala, T. Sevcikova, A. Anilkumar Sithara, V. Kapustova, H. Sahinbegovic, O. Venglar, L. Muronova, L. Broskevicova, S. Nenarokov, D. Bilek, T. Popkova, H. Plonkova, J. Vrana, V. Zidlik, P. Hurnik, M. Havel, M. Hrdinka, Z. Chyra, G. Stracquadanio, M. Simicek, R. Hajek
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CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results Leukemia (IF 11.4) Pub Date : 2024-03-15 Liora M. Schultz, Nikeshan Jeyakumar, Anne Marijn Kramer, Bita Sahaf, Hrishi Srinagesh, Parveen Shiraz, Neha Agarwal, Mark Hamilton, Courtney Erickson, Ashley Jacobs, Jennifer Moon, Christina Baggott, Sally Arai, Sushma Bharadwaj, Laura J. Johnston, Michaela Liedtke, Robert Lowsky, Everett Meyer, Robert Negrin, Andrew Rezvani, Judy Shizuru, Surbhi Sidana, Emily Egeler, Sharon Mavroukakis, Ramya Tunuguntla
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Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease Leukemia (IF 11.4) Pub Date : 2024-03-15 Kira Behrens, Maria Kauppi, Elizabeth M. Viney, Andrew J. Kueh, Craig D. Hyland, Tracy A. Willson, Liam Salleh, Carolyn A. de Graaf, Jeffrey J. Babon, Marco J. Herold, Nicos A. Nicola, Warren S. Alexander
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NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia Leukemia (IF 11.4) Pub Date : 2024-03-15 Alice Bonato, Supriya Chakraborty, Riccardo Bomben, Giulia Canarutto, Giulia Felician, Claudio Martines, Antonella Zucchetto, Federico Pozzo, Marija Vujovikj, Jerry Polesel, Annalisa Chiarenza, Maria Ilaria Del Principe, Giovanni Del Poeta, Giovanni D’Arena, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Silvano Piazza, Aleksandar J. Dimovski, Valter Gattei, Dimitar G. Efremov
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Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms Leukemia (IF 11.4) Pub Date : 2024-03-14 Tatiana Raskovalova, Marie-Christine Jacob, Sophie Park
In a letter to the editor, Oelschlaegel et al. [1] describes the new flow cytometry score (MDS-PB13) for the diagnosis of myelodysplastic syndromes (MDS) that relies on aberrant antigen expression of thirteen parameters in different cell populations of peripheral blood with 79–81% specificity and 61–70% sensibility. Suspicion of MDS is the commonest reason for bone marrow aspirate and biopsy in older
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Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity Leukemia (IF 11.4) Pub Date : 2024-03-11 Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde A. Miles, Robert L. Bowman, Troy Robinson, Ken Furudate, Hidetaka Uryu, Tomoyuki Tanaka, Yuya Sasaki, Asiri Ediriwickrema, Brooks Benard, Andrew J. Gentles, Ross Levine, Niko Beerenwinkel, Koichi Takahashi, Ravindra Majeti
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Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF Leukemia (IF 11.4) Pub Date : 2024-03-12 Daniela Žáčková, Lukáš Semerád, Edgar Faber, Hana Klamová, Lukáš Stejskal, Petra Bělohlávková, Michal Karas, Eduard Cmunt, Olga Černá, Jiřina Procházková, Petra Čičátková, Anežka Kvetková, Tomáš Horňák, Ivana Skoumalová, Dana Srbová, Cyril Šálek, David Buffa, Jaroslava Voglová, Tomáš Jurček, Adam Folta, Ivana Ježíšková, Hana Žižková, Kateřina Machová Poláková, Tomáš Papajík, Pavel Žák, Pavel Jindra
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Allogeneic haematopoietic cell transplantation for advanced systemic mastocytosis: Best practice recommendations on behalf of the EBMT Practice Harmonisation and Guidelines Committee Leukemia (IF 11.4) Pub Date : 2024-03-12 Donal P. McLornan, Tomasz Czerw, Gandhi Damaj, Mark Ethell, Carmelo Gurnari, Juan Carlos Hernández-Boluda, Nicola Polverelli, Juliana Schwaab, Katja Sockel, Greco Raffaella, Francesco Onida, Isabel Sánchez-Ortega, Giorgia Battipaglia, Chiara Elena, Jason Gotlib, Andreas Reiter, Julien Rossignol, Celalettin Ustun, Peter Valent, Ibrahim Yakoub-Agha, Deepti H. Radia
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STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response Leukemia (IF 11.4) Pub Date : 2024-03-11 Bhakti Patel, Yifan Zhou, Rachel L. Babcock, Feiyang Ma, M. Anna Zal, Dhiraj Kumar, Yusra B. Medik, Laura M. Kahn, Josué E. Pineda, Elizabeth M. Park, Sarah M. Schneider, Ximing Tang, Maria Gabriela Raso, Collene R. Jeter, Tomasz Zal, Karen Clise-Dwyer, Khandan Keyomarsi, Filippo G. Giancotti, Simona Colla, Stephanie S. Watowich
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Childbirth rates in women with myeloproliferative neoplasms Leukemia (IF 11.4) Pub Date : 2024-03-09 Anna Ravn Landtblom, Therese M-L Andersson, Anna L. V. Johansson, Frida E. Lundberg, Jan Samuelsson, Magnus Björkholm, Malin Hultcrantz
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Redefining high risk multiple myeloma with an APOBEC/Inflammation-based classifier Leukemia (IF 11.4) Pub Date : 2024-03-09 Sarah Grasedieck, Afsaneh Panahi, Matthew C. Jarvis, Faezeh Borzooee, Reuben S. Harris, Mani Larijani, Hervé Avet-Loiseau, Mehmet Samur, Nikhil Munshi, Kevin Song, Arefeh Rouhi, Florian Kuchenbauer
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Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15 Leukemia (IF 11.4) Pub Date : 2024-03-08 Cong Liu, Qiu Lan, Shuo Cao, Fei Zheng, Yiwen Liang, Jingyi Shen, Ying Wang, Takayuki Ikezoe, Kailin Xu, Bin Pan
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Myelodysplastic neoplasms dissected into indolent, leukaemic and unfavourable subtypes by computational clustering of haematopoietic stem and progenitor cells Leukemia (IF 11.4) Pub Date : 2024-03-08 Margot F. van Spronsen, Sofie Van Gassen, Carolien Duetz, Theresia M. Westers, Yvan Saeys, Arjan A. van de Loosdrecht
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Targeting the innate immune system in pediatric and adult AML Leukemia (IF 11.4) Pub Date : 2024-03-08 Alicia Perzolli, Joost B. Koedijk, C. Michel Zwaan, Olaf Heidenreich
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Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study Leukemia (IF 11.4) Pub Date : 2024-03-08 Annalisa Chiappella, Beatrice Casadei, Patrizia Chiusolo, Alice Di Rocco, Silva Ljevar, Martina Magni, Piera Angelillo, Anna Maria Barbui, Ilaria Cutini, Anna Dodero, Francesca Bonifazi, Maria Chiara Tisi, Stefania Bramanti, Maurizio Musso, Mirko Farina, Massimo Martino, Mattia Novo, Giovanni Grillo, Francesca Patriarca, Giulia Zacchi, Mauro Krampera, Martina Pennisi, Eugenio Galli, Maurizio Martelli
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The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma Leukemia (IF 11.4) Pub Date : 2024-03-07 Hildo C. Lantermans, Fangxue Ma, Annemieke Kuil, Sanne van Kesteren, Sevtap Yasinoglu, Guang Yang, Sara J. Buhrlage, Jinhua Wang, Nathanael S. Gray, Marie José Kersten, Steven P. Treon, Steven T. Pals, Marcel Spaargaren
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Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-03-07 Melvin E. Thomas, Wenqing Qi, Michael P. Walsh, Jing Ma, Tamara Westover, Sherif Abdelhamed, Lauren J. Ezzell, Chandra Rolle, Emily Xiong, Wojciech Rosikiewicz, Beisi Xu, Allister J. Loughran, Shondra M. Pruett-Miller, Laura J. Janke, Jeffery M. Klco
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Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis: A retrospective analysis of the DRST and GREM registries Leukemia (IF 11.4) Pub Date : 2024-03-06 Johannes Lübke, Deborah Christen, Juliana Schwaab, Anne Kaiser, Nicole Naumann, Khalid Shoumariyeh, Madlen Jentzsch, Katja Sockel, Judith Schaffrath, Francis A. Ayuk, Matthias Stelljes, Inken Hilgendorf, Elisa Sala, Jennifer Kaivers, Stefan Schönland, Christoph Wittke, Bernd Hertenstein, Markus Radsak, Ulrich Kaiser, Valeska Brückl, Nicolaus Kröger, Tim H. Brümmendorf, Wolf-Karsten Hofmann, Stefan
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5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies Leukemia (IF 11.4) Pub Date : 2024-03-05 Jasmine C. Wong, Kelley M. Weinfurtner, Tamara Westover, Jangkyung Kim, Eric J. Lebish, Maria del pilar Alzamora, Benjamin J. Huang, Michael Walsh, Sherif Abdelhamed, Jing Ma, Jeffery M. Klco, Kevin Shannon
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Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol Leukemia (IF 11.4) Pub Date : 2024-03-02 Maria Agustina Perusini, Claire Andrews, Atenafu G. Eshetu, Vikas Gupta, Dawn Maze, Karen W. L. Yee, Aniket Bankar, Marta B. Davidson, Guillaume Richard-Carpentier, Steven M. Chan, Aaron D. Schimmer, Jad Sibai, Salman Alharbi, Josephine A. Lucero, Swe Mar Linn, Mark D. Minden, Andre C. Schuh, Hassan Sibai
We read with interest the recent report by Valtis et al. [1], in which the authors assessed the importance of acute lymphoblastic leukemia (ALL) treatment protocol completion, and in particular of the total asparaginase (ASP) received doses, on the survival of 1159 childhood and 332 Adolescent and Young Adult (AYA) patients with Philadelphia chromosome-negative (Ph-) ALL, who were treated on four sequential
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Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion Leukemia (IF 11.4) Pub Date : 2024-03-01 Jingqun Ma, Yen-Chun Liu, Rebecca K. Voss, Jing Ma, Ajay Palagani, Elizabeth Caldwell, Wojciech Rosikiewicz, Maria Cardenas, Scott Foy, Masayuki Umeda, Mark R. Wilkinson, Hiroto Inaba, Jeffery M. Klco, Jeffrey E. Rubnitz, Lu Wang
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Long-term outcomes after upfront second-generation tyrosine kinase inhibitors for chronic myeloid leukemia: managing intolerance and resistance Leukemia (IF 11.4) Pub Date : 2024-02-29 Simone Claudiani, Farhan Chughtai, Afzal Khan, Chloe Hayden, Fiona Fernando, Jamshid Khorashad, Victoria Orovboni, Glenda Scandura, Andrew Innes, Jane F. Apperley, Dragana Milojkovic
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Nucleic acid therapeutics as differentiation agents for myeloid leukemias Leukemia (IF 11.4) Pub Date : 2024-02-29 Olivia Kovecses, François E. Mercier, Maureen McKeague
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circFAM193B interaction with PRMT6 regulates AML leukemia stem cells chemoresistance through altering the oxidative metabolism and lipid peroxidation Leukemia (IF 11.4) Pub Date : 2024-02-29 Xinyu Yang, Jinting Liu, Wancheng Liu, Hanyang Wu, Yihong Wei, Xiaodong Guo, Hexiao Jia, Can Can, Dongmei Wang, Xiang Hu, Daoxin Ma
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Phase III randomized trial of Thal+ZLD versus ZLD in patients with asymptomatic multiple myeloma – updated results after 18-year follow-up Leukemia (IF 11.4) Pub Date : 2024-02-28 Nadine Abdallah, Thomas E. Witzig, Shaji K. Kumar, Martha Q. Lacy, Suzanne R. Hayman, Angela Dispenzieri, Vivek Roy, Morie A. Gertz, P. Leif Bergsagel, S. Vincent Rajkumar
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Influence of co-mutational patterns in disease phenotype and clinical outcomes of chronic myelomonocytic leukemia Leukemia (IF 11.4) Pub Date : 2024-02-28 Guillermo Montalban-Bravo, Juan Jose Rodriguez-Sevilla, David Michael Swanson, Rashmi Kanagal-Shamanna, Danielle Hammond, Kelly Chien, Koji Sasaki, Elias Jabbour, Courtney DiNardo, Koichi Takahashi, Nicholas Short, Ghayas C. Issa, Naveen Pemmaraju, Tapan Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sanam Loghavi, Sherry Pierce, Carlos Bueso-Ramos, Hagop Kantarjian, Guillermo Garcia-Manero
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Germline variants in patients developing second malignant neoplasms after therapy for pediatric acute lymphoblastic leukemia—a case-control study Leukemia (IF 11.4) Pub Date : 2024-02-27 Stefanie V. Junk, Alisa Förster, Gunnar Schmidt, Martin Zimmermann, Birthe Fedders, Bernd Haermeyer, Anke K. Bergmann, Anja Möricke, Gunnar Cario, Bernd Auber, Martin Schrappe, Christian P. Kratz, Martin Stanulla
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Long-term outcomes by bone marrow B-cell depletion from the R2W trial of bortezomib with cyclophosphamide and rituximab in Waldenstrőm macroglobulinaemia Leukemia (IF 11.4) Pub Date : 2024-02-26 Ruth de Tute, Nicholas Counsell, Laura Clifton-Hadley, Shirley D’Sa, Guy Pratt, Gavin Campbell, Lauren Campbell, Ross Sadler, William Townsend, Bilyana Popova, Paul Smith, Oliver Schofield, Roger Owen, Rebecca Auer
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Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells Leukemia (IF 11.4) Pub Date : 2024-02-24 Weiwei Yi, Jinhua Zhang, Yingxin Huang, Qiang Zhan, Mi Zou, Xiang Cheng, Xuguang Zhang, Zhinan Yin, Si Tao, Hui Cheng, Fudi Wang, Jun Guo, Zhenyu Ju, Zhiyang Chen
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Chronic myeloid leukemia diagnosed in pregnancy: management and outcome of 87 patients reported to the European LeukemiaNet international registry Leukemia (IF 11.4) Pub Date : 2024-02-23 Ekaterina Chelysheva, Jane Apperley, Anna Turkina, Mohamed A. Yassin, Delphine Rea, Franck E. Nicolini, Daniela Barraco, Khamida Kazakbaeva, Sukhrob Saliev, Adi Shacham Abulafia, Salam Al-Kindi, Jennifer Byrne, Harry F. Robertson, Marco Cerrano, Roman Shmakov, Evgenia Polushkina, Paolo de Fabritiis, Malgorzata Monika Trawinska, Elisabetta Abruzzese
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The evolution of preclinical models for myelodysplastic neoplasms Leukemia (IF 11.4) Pub Date : 2024-02-23 Alain Mina, Steven Pavletic, Peter D. Aplan
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Phase 2 study using low dose cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis Leukemia (IF 11.4) Pub Date : 2024-02-22 Long Chang, Min Lang, He Lin, Hao Cai, Ming-Hui Duan, Dao-Bin Zhou, Xin-Xin Cao
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Impact of socioeconomic disparities on outcomes in adults undergoing allogeneic hematopoietic cell transplantation for acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-02-22 Daniel J. Olivieri, Megan Othus, Corentin Orvain, Eduardo Rodríguez-Arbolí, Filippo Milano, Brenda M. Sandmaier, Irum Khan, Chris Davis, Ryan S. Basom, Frederick R. Appelbaum, Roland B. Walter
Racial and socioeconomic disparities impact outcomes after chemotherapy and limit access to allogeneic hematopoietic cell transplantation (HCT) in acute myeloid leukemia (AML), yet studies have yielded mixed results on the influence of disparities on post-HCT outcomes. Therefore, we studied 1024 adults with AML who underwent allogeneic HCT between 5/2006 and 10/2021 at a single large university-affiliated
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Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered Leukemia (IF 11.4) Pub Date : 2024-02-22 Mariusz Z. Ratajczak, Janina Ratajczak
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Germline CHEK2 mutations in patients with myeloid neoplasms Leukemia (IF 11.4) Pub Date : 2024-02-20 Lucie Freiman, Lise Larcher, Giulia Tueur, Nadia Vasquez, Mélanie Da Costa, Matthieu Duchmann, Emmanuel Raffoux, Lionel Adès, Pierre Fenaux, Jean Soulier, Nicolas Duployez, Emmanuelle Clappier, Marie Sébert
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Hypomethylating agents plus venetoclax compared with intensive induction chemotherapy regimens in molecularly defined secondary AML Leukemia (IF 11.4) Pub Date : 2024-02-20 Shai Shimony, Jan Philipp Bewersdorf, Rory M. Shallis, Yiwen Liu, Eva J. Schaefer, Amer M. Zeidan, Aaron D. Goldberg, Eytan M. Stein, Guido Marcucci, R. Coleman Lindsley, Evan C. Chen, Jorge Ramos Perez, Anthony Stein, Daniel J. DeAngelo, Donna S. Neuberg, Richard M. Stone, Brian Ball, Maximilian Stahl
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Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis Leukemia (IF 11.4) Pub Date : 2024-02-20 Hélène Duparc, Delphine Muller, Laure Gilles, Agathe L. Chédeville, Mira El Khoury, Rose Guignard, Najet Debili, Monika Wittner, Alexandre Kauskot, Florence Pasquier, Iléana Antony-Debré, Caroline Marty, William Vainchenker, Isabelle Plo, Hana Raslova
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Genomic features reveal potential benefit of adding anti-PD-1 immunotherapy to treat non-upper aerodigestive tract natural killer/T-cell lymphoma Leukemia (IF 11.4) Pub Date : 2024-02-20 Zegeng Chen, He Huang, Huageng Huang, Le Yu, Huawei Weng, Jian Xiao, Liqun Zou, Huilai Zhang, Chaoyong Liang, Hui Zhou, Hongqiang Guo, Zhao Wang, Zhiming Li, Tao Wu, Hongyu Zhang, Huijing Wu, Zhigang Peng, Linzhu Zhai, Xinggui Chen, Yang Liang, Huangming Hong, Tongyu Lin
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Clinical impact of genetic alterations including germline DDX41 mutations in MDS/low-blast count AML patients treated with azacitidine-based regimens Leukemia (IF 11.4) Pub Date : 2024-02-17 Marie Sébert, Lucie Freiman, Cendrine Chaffaut, Agnès Guerci, Pierre Peterlin, Sylvain Thépot, Odile Beyne-Rauzy, Sophie Park, Thomas Cluzeau, Fatiha Chermat, Pierre Fenaux, Claude Preudhomme, Emmanuelle Clappier, Sylvie Chevret, Lionel Adès, Nicolas Duployez, Matthieu Duchmann
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Comparison of karyotype scoring guidelines for evaluating karyotype complexity in chronic lymphocytic leukemia Leukemia (IF 11.4) Pub Date : 2024-02-19 Matthew R. Avenarius, Ying Huang, Adam S. Kittai, Seema A. Bhat, Kerry A. Rogers, Michael R. Grever, Jennifer A. Woyach, Cecelia R. Miller
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Late morbidity and mortality after autologous blood or marrow transplantation for lymphoma in children, adolescents and young adults—a BMTSS report Leukemia (IF 11.4) Pub Date : 2024-02-19 Anna Sällfors Holmqvist, Qingrui Meng, Chen Dai, Lindsey Hageman, Wendy Landier, Jessica Wu, Liton F. Francisco, Elizabeth Schlichting Ross, Nora Balas, Alysia Bosworth, Hok Sreng Te, Ravi Bhatia, Joseph Rosenthal, F. Lennie Wong, Daniel Weisdorf, Saro H. Armenian, Smita Bhatia
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Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease Leukemia (IF 11.4) Pub Date : 2024-02-17 Tiziana Bruno, Valeria Catena, Giacomo Corleone, Clelia Cortile, Maria Chiara Cappelletto, Barbara Bellei, Francesca De Nicola, Bruno Amadio, Svitlana Gumenyuk, Francesco Marchesi, Ombretta Annibali, Giovanni Blandino, Maurizio Fanciulli, Silvia Di Agostino
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Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children’s Oncology Group Report Leukemia (IF 11.4) Pub Date : 2024-02-15 N. J. DelRocco, M. L. Loh, M. J. Borowitz, S. Gupta, K. R. Rabin, P. Zweidler-McKay, K. W. Maloney, L. A. Mattano, E. Larsen, A. Angiolillo, R. J. Schore, M. J. Burke, W. L. Salzer, B. L. Wood, A. J. Carroll, N. A. Heerema, S. C. Reshmi, J. M. Gastier-Foster, R. Harvey, I. M. Chen, K. G. Roberts, C. G. Mullighan, C. Willman, N. Winick, W. L. Carroll, R. E. Rau, D. T. Teachey, S. P. Hunger, E. A. Raetz
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The UBE2J2/UBE2K-MARCH5 ubiquitination machinery regulates apoptosis in response to venetoclax in acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-02-16 Shan Lin, Constanze Schneider, Angela H. Su, Gabriela Alexe, David E. Root, Kimberly Stegmaier
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Combining lenalidomide with erythropoiesis stimulating agents: a party of one Leukemia (IF 11.4) Pub Date : 2024-02-15 Namrata S. Chandhok, Mikkael A. Sekeres
“Solitude, sometimes is best society” - John Milton, Paradise Lost. The myelodysplastic syndromes (MDS) represent an inherently complex collection of disorders arising from genetic and epigenetic alterations that accumulate over years or even decades. MDS subtypes have biologically and clinically distinct pathologies, contributing to the considerable variability observed in both clinical progression
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Mapping AML heterogeneity - multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses Leukemia (IF 11.4) Pub Date : 2024-02-15 Jeppe F. Severens, E. Onur Karakaslar, Bert A. van der Reijden, Elena Sánchez-López, Redmar R. van den Berg, Constantijn J. M. Halkes, Peter van Balen, Hendrik Veelken, Marcel J. T. Reinders, Marieke Griffioen, Erik B. van den Akker
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Circulating tumor cells in Waldenström macroglobulinemia Leukemia (IF 11.4) Pub Date : 2024-02-09 Clémentine Boccon-Gibod, Elise Sourdeau, Pierre Morel, Elise Chapiro, Florence Nguyen-Khac, Clotilde Bravetti, Frédéric Davi, Véronique Morel, Nicolas Gauthier, Adrien Grenier, Inès Boussen, Sylvain Choquet, Véronique Leblond, Magali Le Garff-Tavernier, Marine Baron, Damien Roos-Weil
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Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development Leukemia (IF 11.4) Pub Date : 2024-02-07 Lin Yan, Shuiyi Tan, Haihong Wang, Hao Yuan, Xiaohui Liu, Yi Chen, Hugues de Thé, Jun Zhu, Jun Zhou
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LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression Leukemia (IF 11.4) Pub Date : 2024-02-06 Yanan Li, Jonny Mendoza-Castrejon, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, David Bryder, Jeffrey A. Magee
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Clinical Features and Long-Term Outcomes of a Pan-Canadian Cohort of Adolescents and Young Adults with Myeloproliferative Neoplasms: A Canadian MPN Group Study Leukemia (IF 11.4) Pub Date : 2024-02-06 James T. England, Natasha Szuber, Shireen Sirhan, Tom Dunne, Sonia Cerquozzi, Madeleine Hill, Pierre J. A. Villeneuve, Jenny M. Ho, Bekim Sadikovic, Pratibha Bhai, Nupur Krishnan, Sebastian Dowhanik, Chris Hillis, Jose-Mario Capo-Chichi, Hubert Tsui, Verna Cheung, Karine Gauthier, Hassan Sibai, Marta B. Davidson, Aniket Bankar, Rouslan Kotchetkov, Vikas Gupta, Dawn Maze
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Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL Leukemia (IF 11.4) Pub Date : 2024-02-02 Ricky Tirtakusuma, Paul Milne, Helen J. Blair, Yuzhe Shi, Simon Bomken, Olaf Heidenreich
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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-02-02 David E. Frankhouser, Russell C. Rockne, Lisa Uechi, Dandan Zhao, Sergio Branciamore, Denis O’Meally, Jihyun Irizarry, Lucy Ghoda, Haris Ali, Jeffery M. Trent, Stephen Forman, Yu-Hsuan Fu, Ya-Huei Kuo, Bin Zhang, Guido Marcucci
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Determinants of lenalidomide response with or without erythropoiesis-stimulating agents in myelodysplastic syndromes: the HOVON89 trial Leukemia (IF 11.4) Pub Date : 2024-01-31 A. A. van de Loosdrecht, E. M. P. Cremers, C. Alhan, C. Duetz, F. E. M. in ’t Hout, H. A. Visser-Wisselaar, D. A. Chitu, A. Verbrugge, S. M. Cunha, G. J. Ossenkoppele, J. J. W. M. Janssen, S. K. Klein, E. Vellenga, G. A. Huls, P. Muus, S. M. C. Langemeijer, G. E. de Greef, P. A. W. te Boekhorst, M. H. G. Raaijmakers, M. van Marwijk Kooy, M. C. Legdeur, J. J. Wegman, W. Deenik, O. de Weerdt, T. M. van
A randomized phase-II study was performed in low/int-1 risk MDS (IPSS) to study efficacy and safety of lenalidomide without (arm A) or with (arm B) ESA/G-CSF. In arm B, patients without erythroid response (HI-E) after 4 cycles received ESA; G-CSF was added if no HI-E was obtained by cycle 9. HI-E served as primary endpoint. Flow cytometry and next-generation sequencing were performed to identify predictors
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Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia Leukemia (IF 11.4) Pub Date : 2024-01-29 Merete Dam, Maddalena Centanni, Lena E. Friberg, Daniel Centanni, Mats O. Karlsson, Line Stensig Lynggaard, Inga Maria Johannsdottir, Hilde Skuterud Wik, Johan Malmros, Goda Elizabeta Vaitkeviciene, Laimonas Griskevicius, Helene Hallböök, Ólafur Gísli Jónsson, Ulrik Overgaard, Kjeld Schmiegelow, Stefan Nygaard Hansen, Mats Heyman, Birgitte Klug Albertsen
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Dose modification dynamics of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) from the PACE and OPTIC trials Leukemia (IF 11.4) Pub Date : 2024-01-29 Elias Jabbour, Jane Apperley, Jorge Cortes, Delphine Rea, Michael Deininger, Elisabetta Abruzzese, Charles Chuah, Daniel J. DeAngelo, Andreas Hochhaus, Jeffrey H. Lipton, Michael Mauro, Franck Nicolini, Javier Pinilla-Ibarz, Gianantonio Rosti, Philippe Rousselot, Neil P. Shah, Moshe Talpaz, Alexander Vorog, Xiaowei Ren, Hagop Kantarjian
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Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial Leukemia (IF 11.4) Pub Date : 2024-01-26 Hjalmar Flygt, Stina Söderlund, Johan Richter, Susanne Saussele, Perttu Koskenvesa, Leif Stenke, Satu Mustjoki, Andreja Dimitrijevic, Jesper Stentoft, Waleed Majeed, Lydia Roy, Dominik Wolf, Arta Dreimane, Bjørn Tore Gjertsen, Tobias Gedde-Dahl, Erik Ahlstrand, Berit Markevärn, Henrik Hjorth-Hansen, Jeroen Janssen, Ulla Olsson-Strömberg
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Impact of hemodilution on flow cytometry based measurable residual disease assessment in acute myeloid leukemia Leukemia (IF 11.4) Pub Date : 2024-01-25 Jesse M. Tettero, Maaike E. Heidinga, Tim R. Mocking, Glenn Fransen, Angèle Kelder, Willemijn J. Scholten, Alexander N. Snel, Lok Lam Ngai, Costa Bachas, Arjan A. van de Loosdrecht, Gert J. Ossenkoppele, David C. de Leeuw, Jacqueline Cloos, Jeroen J. W. M. Janssen
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Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts Leukemia (IF 11.4) Pub Date : 2024-01-23 Jacob S. Appelbaum, Andrew H. Wei, Sumithra J. Mandrekar, Ing S. Tiong, Chong Chyn Chua, Tse-Chieh Teh, Chun Yew Fong, Stephen B. Ting, Daniela Weber, Axel Benner, Hannah Hill, Maral Saadati, Jun Yin, Richard M. Stone, Guillermo Garcia-Manero, Harry P. Erba, Geoffrey L. Uy, Guido Marcucci, Richard A. Larson, Abin Thomas, Sylvie D. Freeman, Nuria Marquez Almuina, Konstanze Döhner, Ian Thomas, Nigel
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The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification Leukemia (IF 11.4) Pub Date : 2024-01-23 K. Nachtkamp, C. Strupp, M. Vukelja, A. Kasprzak, D. Haase, C. Ganster, B. Hildebrandt, B. Betz, A. Giagounidis, C. Aul, S. Blum, W. K. Hofmann, M. Pfeilstöcker, P. Valent, M. Lübbert, M. Seidl, M. Rudelius, R. Stauder, O. Krieger, K. S. Götze, J. Bobak, A. Kündgen, F. Schulz, S. Dietrich, G. Kobbe, N. Gattermann, U. Germing
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Peri-transplant flow-MRD assessment of cells with leukemic stem cells (LSC) associated phenotype in AML patients undergoing allogeneic stem cell transplantation in CR Leukemia (IF 11.4) Pub Date : 2024-01-23 Evgeny Klyuchnikov, Anita Badbaran, Radwan Massoud, Petra Freiberger, Christine Wolschke, Francis Ayuk, Boris Fehse, Ulrike Bacher, Nicolaus Kröger