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Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms Cancer Investig. (IF 2.4) Pub Date : 2024-03-14 Fatih Gürler, Selin Aktürk Esen, Bediz Kurt İnci, Osman Sütçüoğlu, Gökhan Uçar, Orhun Akdoğan, Doğan Uncu, Nesrin Turhan, Nalan Akyürek, Nuriye Özdemir, Ahmet Özet, Ozan Yazıcı
We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, and MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with im...
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Targeting EGFR and VEGFR-2 Kinases With Nanoparticles: A Computational Approach for Cancer Therapy Advancement Cancer Investig. (IF 2.4) Pub Date : 2024-03-14 Ibrahim Khater, Aaya Nassar
The study investigates titanium and zinc nanoparticles as inhibitors for the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2), pivotal regulators ...
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A Review on Emerging Techniques for Diagnosis of Colorectal Cancer Cancer Investig. (IF 2.4) Pub Date : 2024-02-26 Shruthi Nagainallur Ravichandran, Diptimayee Das, Erica Katriel Dayananda, Amit Dey, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Xiao-Feng Sun, Surajit Pathak
Common detection methods in practice for diagnosing colorectal cancer (CRC) are painful and invasive leading to less participation of individuals for CRC diagnosis. Whereas, improved or enhanced im...
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NGS-based Tissue-Blood TMB Comparison and Blood-TMB Monitoring in Stage-III Non-Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy Cancer Investig. (IF 2.4) Pub Date : 2024-02-23 Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu
In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Bas...
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Immune Cell Infiltration Types as Biomarkers for the Recurrence Diagnosis and Prognosis of Bladder Cancer Cancer Investig. (IF 2.4) Pub Date : 2024-02-23 Hongwei Xu, Dapeng Sun, Dahong Zhou, Shiheng Sun
This study aimed to investigate the role of infiltrating immune cell types in diagnosing and predicting bladder cancer recurrence. This study mainly applied some algorithms, including Estimate the ...
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Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma Cancer Investig. (IF 2.4) Pub Date : 2024-02-22 Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri
Crocin is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse ...
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Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis Cancer Investig. (IF 2.4) Pub Date : 2024-02-12 Konstantinos Perivoliotis, Panagiotis Ntellas, Katerina Dadouli, Athina A. Samara, Sotirios Sotiriou, Maria Ioannou, Konstantinos Tepetes
A meta-analysis was designed and conducted to estimate the effect of tumoral microvessel density (MVD) on the survival of patients with osteosarcoma. There was no difference between high and low MV...
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Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women Cancer Investig. (IF 2.4) Pub Date : 2024-02-12 Tina Parsamand, Fariba Zarani, Leili Panaghi, Cannas Kwok
Regular screening can lead to early diagnosis of breast cancer. Australia is one of the countries with a high rate of participation in breast cancer screening, while in Iran, most patients are diag...
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COVID-19 Outbreak Impact on Cancer Multidisciplinary Team Meetings. A Multicenter French Experience Cancer Investig. (IF 2.4) Pub Date : 2024-02-05 Wafa Bouleftour, Amandine Mondiere-Wichurski, Pierre Fournel, Quentin Reboul
Multidisciplinary team meeting (MDT) became a standard of care in cancer management. The COVID-19 epidemic induced unprecedented pressure on the health system. The impact of this health crisis on M...
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Gain of Chromosome 5q Predicts a Favorable Prognosis in Localized Renal Cell Carcinoma Cancer Investig. (IF 2.4) Pub Date : 2024-02-05 Cedric Lebacle, Aydin Pooli, Brian Shuch, Nagesh Rao, Karim Chamie, Nils Kroeger, Izak Faiena, Sandy Liu, Erika L. Wood, Arie Belldegrun, Alexandra Drakaki, Allan J. Pantuck
Approximately 65% of renal cell carcinomas (RCC) are diagnosed at a localized stage. We investigated the chromosome 5q gain impact on disease-free survival (DFS) in RCC patients. Overall, 676 patie...
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The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure Cancer Investig. (IF 2.4) Pub Date : 2024-02-01 Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
Published in Cancer Investigation (Ahead of Print, 2024)
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Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease Cancer Investig. (IF 2.4) Pub Date : 2024-02-01 Faruk Tas, Akin Ozturk, Kayhan Erturk
Comorbidity, the most important components of which are hypertension/coronary artery disease (HTN/CAD), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD), is frequently encou...
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Impact of the Multidisciplinary Cancer Team on the Diagnostic and Therapeutic Care Pathway of Early Breast Cancer Patients and Perception of Team Members: The Experience of a Cancer Centre in Italy Cancer Investig. (IF 2.4) Pub Date : 2024-01-22 A. M. L. Capobianco, G. Gallucci, L. Lapadula, G. Dinardo, G. La Torre, N. Sisti, L. G. Sisti
Literature on the role of multidisciplinary team (MDT) in cancer is still controversial. We aimed to investigate MDT impact on a panel of indicators in breast cancer care in a single-center retrosp...
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Efficacy of Adjuvant First-Generation TKIs versus Chemotherapy in Patients with Completely Resected EGFR-Mutant Non-Small Cell Lung Cancer: A Meta-Analysis Cancer Investig. (IF 2.4) Pub Date : 2024-01-15 Bin Shen, Dongping Wu, Jianjiang Liu, Yang Yang
The use of adjuvant first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC) remains controve...
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Human Mycobiota and Its Role in Cancer Progression, Diagnostics and Therapeutics: A Link Lesser-Known Cancer Investig. (IF 2.4) Pub Date : 2024-01-07 Souvik Roy, Dhrisaj Ray, Ishani Laha, Lopamudra Choudhury
Although not as well studied as the bacterial component of the human microbiota, the commensal fungi or mycobiota play important roles in maintaining our health by augmenting our immune system. Thi...
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THE NATURE, ORIGIN, AND EVOLUTION OF LIFE: Part IV Cellular Differentiation and the Emergence of Multicellular Life Cancer Investig. (IF 2.4) Pub Date : 2024-01-04 Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
Published in Cancer Investigation (Just accepted, 2024)
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Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Serdar Celik, Tekincan Aktas, Ozde Gokbayrak, Aylin Erol, Kutsal Yorukoglu, Batuhan Yilmaz, Hilmi Sari, Zekiye Altun, Mehmet Ugur Mungan, Ilhan Celebi, Guven Aslan, Safiye Aktas
The aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving phosphatidylinositol-3-OH kinase (PIK3)/AKT/mammalian target of rapamycin (mTOR) ...
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Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors after Standard of Care Systemic Treatment Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Vicente Valentí, Laia Capdevila, Isabel Ruiz, Javier Ramos, Joan Badía, Susana Blázquez, Óscar Villuendas, Cristina Pérez, Laura Fernández-Sender, Mónica Córdoba, Carlos Alonso-Villaverde
Immunogenic cell death (ICD) is known for releasing damage-associated molecular patterns (DAMPs) from tumor cells. We aimed to find ICD signals by assessing the variation of plasmatic DAMPs (HMGB1,...
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Significance of the Pretreatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting the Response to Neoadjuvant Chemotherapy and Survival Rates in Extremity Osteosarcoma: A Multicentre Prospective Study Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Amir Mohammad Arefpour, Maryam Garousi, Ahmad Foroughi, Saeed Hosseini, Mohadeseh Shahin, Seyed Alireza Javadinia
We aimed to assess the effects of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios on the response to neoadjuvant chemotherapy and survival rates in patients with extremity o...
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Improving Cancer Patient Outcomes and Cost-Effectiveness: A Markov Simulation of Improved Early Detection, Side Effect Management, and Palliative Care Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Raphael E. Cuomo
I employed a Markov model to simulate outcomes for a cohort of 1,000 hypothetical patients, comparing improvements in early detection, side effect management, and palliative care over a ten-year pe...
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Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Veronika Hanusova, Petra Matouskova, Monika Manethova, Jiri Soukup, Stanislav John, Martin Zofka, Hana Vošmikova, Lukas Krbal, Emil Rudolf
Colorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in t...
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Recurrence Patterns and Clinical Management after a Positive Sentinel Node Biopsy in Melanoma Patients Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Jacqueline N. de Menezes, Dante A. S. M. Arra, Matheus M. Lôbo, Clovis A. L. Pinto, João P. S. N. Lima, Milton J. B. Silva, João P. Duprat Neto, Eduardo Bertolli
Introduction melanoma patients who become stage III after a positive sentinel node biopsy (SNB) may have several patterns of recurrence patients and methods retrospective analysis of melanoma patie...
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Assessment of Swallowing Function in Patients with Head and Neck Squamous Cell Carcinoma in High vs. Low Dose Cisplatin Cancer Investig. (IF 2.4) Pub Date : 2024-01-02 Amber Veldman, Annika van Oosbree, Madisyn Braun, Aarabhi Gurumoorthy, William C. Spanos, Steven Powell
Cisplatin-based therapies are standard-of-care for advanced-stage head and neck squamous cell carcinoma (HNSCC). Treatment regimens include 3 weeks of high-dose bolus cisplatin or 6–7 weeks of low-...
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Single Nucleotide Polymorphisms Associated with Prostate Cancer Progression: A Systematic Review Cancer Investig. (IF 2.4) Pub Date : 2023-12-18 Daniel Felipe Mendivelso González, Santiago Andrés Sánchez Villalobos, Andrea Estefanía Ramos, Wendy Johana Montero Ovalle, Martha Lucía Serrano López
New biomarkers of progression in patients with prostate cancer (PCa) are needed to improve their classification and clinical management. This systematic review investigated the relationship between...
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Spine Instability Neoplastic Score (SINS) as a Predictive Tool in Conventional Radiotherapy: A Narrative Review Cancer Investig. (IF 2.4) Pub Date : 2023-11-17 Donato Pezzulla, Alessia Re, Savino Cilla, Milena Ferro, Carmela Romano, Paolo Bonome, Rossella Di Franco, Paolo Muto, Giancarlo Mattiucci, Francesco Deodato, Gabriella Macchia
This narrative review seeks to identify the SINS score application in the radiation oncology field.This literature review was performed searching papers on MEDLINE published from January 2010 to Au...
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Dose-Dense Docetaxel-Cyclophosphamide and Epirubicin-Cisplatin(ddDCEP): Analysis of an Alternative Platinum-Containing Regimen in 116 Patients with Early Triple Negative Breast Cancer Cancer Investig. (IF 2.4) Pub Date : 2023-11-17 Ashish Singh, Josh Thomas Georgy, Anjana Joel, Divya Bala Thumaty, Ajoy Oommen John, Nithya Ramnath, Tarun K George, Parth Sharma, Shalom Patole, Grace Rebekah, Elanthenral Sigamani, Marie Therese Manipadam, Anish Jacob Cherian, Deepak Thomas Abraham, Mazhuvanchary Jacob Paul, Rajesh Balakrishnan, Patricia Sebastian, Selvamani Backianathan, Raju Titus Chacko
We assessed the efficacy, tolerability, and cost-effectiveness of a novel neoadjuvant regimen comprising docetaxel-cyclophosphamide alternating with epirubicin-cisplatin (ddDCEP) administered biwee...
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Anxiety, Depression, and Coping Strategies during Chemotherapy Treatment: A Comparison of Older and Younger Adults with Advanced Cancer in Brazil Cancer Investig. (IF 2.4) Pub Date : 2023-11-17 Cristiane Decat Bergerot, Errol J. Philip, Paulo Gustavo Bergerot, Marianne Razavi, David Lee, Karen Lynn Clark, Matthew Loscalzo, Sumanta Kumar Pal, William Dale
We sought to examine differences in anxiety, depression and coping strategies among younger (<64-year old) and older (≥65-year old) patients. Patients were assessed at baseline (T1), mid-point (T2)...
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Beyond the Horizon: A Cutting-Edge Review of the Latest Checkpoint Inhibitors in Cancer Treatment Cancer Investig. (IF 2.4) Pub Date : 2023-11-17 Marc Boutros, Fouad Attieh, Antoine Chartouni, Johnny Jalbout, Hampig Raphaël Kourie
Immune checkpoint inhibitors (ICIs) have emerged as a revolutionary paradigm in oncology, offering a potent arsenal against various malignancies by harnessing the body's own immunological prowess. ...
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THE NATURE, ORIGIN, AND EVOLUTION OF LIFE: Part III The Emergence of Complex Life Cancer Investig. (IF 2.4) Pub Date : 2023-11-07 Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
Published in Cancer Investigation (Just accepted, 2023)
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Efficacy and Safety of RET-Specific Kinase Inhibitors in RET-Altered Cancers: A Systematic Review Cancer Investig. (IF 2.4) Pub Date : 2023-10-31 Muhammad Ashar Ali, Syed S. Shah, Rimsha Ali, Shammas Farooq Bajwa, Sana Rehman, Aqsa Anwar, Muhammad Yasir Anwar, Memoona Saeed, Nayab Mirza, Wajeeha Aiman
RET proto-oncogene encodes receptor tyrosine kinase. Selpercatinib and pralsetinib are the only RET-specific tyrosine kinase inhibitors approved by FDA in RET-altered tumors. We searched PubMed, Em...
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Correction Cancer Investig. (IF 2.4) Pub Date : 2023-10-31
Published in Cancer Investigation (Vol. 41, No. 8, 2023)
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The Nature, Origin and Evolution of Life: Part II The Origin of Life Cancer Investig. (IF 2.4) Pub Date : 2023-10-11 Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
Published in Cancer Investigation (Ahead of Print, 2023)
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The Nature, Origin and Evolution of Life: Part I The Fundamental Logic and Organization of Life Cancer Investig. (IF 2.4) Pub Date : 2023-09-28 Gary H. Lyman, Christopher H. Lyman, Nicole M. Kuderer
Published in Cancer Investigation (Vol. 42, No. 1, 2024)
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Perception, Cognition and Thought: Part V Entropy, the Arrow of Time and the Present Cancer Investig. (IF 2.4) Pub Date : 2023-09-11 Gary H. Lyman, Christopher H. Lyman, Nicole M. Kuderer
Published in Cancer Investigation (Vol. 41, No. 10, 2023)
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Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules Cancer Investig. (IF 2.4) Pub Date : 2023-09-08 Ulku Unal, Esra Gov
This study aimed to reveal the drug-repurposing candidates for colorectal cancer (CRC) via drug-repurposing methods and network biology approaches. A novel, differentially co-expressed, highly inte...
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Intraosseous Spindle Cell Rhabdomyosarcoma with MEIS1::NCOA2 Fusion – Case Report with Substantial Clinical Follow-up and Review of the Literature Cancer Investig. (IF 2.4) Pub Date : 2023-09-06 Benjamin F. Smith, Yee-Cheen Doung, Brooke Beckett, Christopher L. Corless, Lara E. Davis, Jessica L. Davis
Spindle cell/sclerosing rhabdomyosarcoma (SSRMS) is a clinicopathologically and molecularly heterogeneous disease. Gene fusions have been identified in intraosseous SSRMS, consisting predominantly ...
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Tumor Differentiation as a Prognostic Marker in Clinically Staged T1bN0 Esophageal Adenocarcinoma Cancer Investig. (IF 2.4) Pub Date : 2023-09-04 Ofer Margalit, Einat Shacham-Shmueli, Gal Strauss, Yu-Xiao Yang, Yaacov R. Lawrence, Alon Ben Nun, Idan Levy, Kim A. Reiss, Talia Golan, Naama Halpern, Dan Aderka, Bruce Giantonio, Ronac Mamtani, Ben Boursi
Current guidelines recommend that clinically staged T1N0 esophageal cancers are to be referred to surgery or endoscopic resection. Using the National Cancer Database, we identified 733 individuals ...
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Perception, Cognition and Thought: Part IV Consciousness, Awareness, and “I” Cancer Investig. (IF 2.4) Pub Date : 2023-08-23 Gary H. Lyman, Christopher H. Lyman, Nicole M. Kuderer
Published in Cancer Investigation (Vol. 41, No. 9, 2023)
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Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal Cancer Investig. (IF 2.4) Pub Date : 2023-08-17 Deborah Blythe Doroshow, Wei Wei, Meenakshi Mehrotra, Daniella Sia, Joseph Paul Eder, Ranjit Bindra, Jane Houldsworth, Patricia LoRusso, Zenta Walther
Abstract Preclinical data suggest that IDH1/2 mutations result in defective homologous recombination repair (HRR). We hypothesized that patients with IDH1/2mt intrahepatic cholangiocarcinoma (IHCC) would benefit more from 1 L platinum chemotherapy than patients with wildtype (WT) tumors. We performed a multicenter retrospective study of 81 patients with unresectable IHCC treated with 1 L platinum with
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Telomere Shortening of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese Patients Cancer Investig. (IF 2.4) Pub Date : 2023-08-10 Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Takashi Tomiyama, Toshiro Fukui, Makoto Naganuma
Abstract Telomere shortening is deeply involved in many types of cancer. Telomere length of esophageal adenocarcinoma (EAC) and Barrett’s esophagus (BE) was examined in Japanese patients. Among BE from cancer free patients (Cancer free), BE from patients with EAC (Adjacent) and EAC tissue (Cancer), Cancer free group presented the longest telomeres, while Cancer group presented the shortest telomeres
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A Nomogram for Predicting Survival in Advanced Non-Small-Cell Lung Carcinoma Patients: A Population-Based Study Cancer Investig. (IF 2.4) Pub Date : 2023-08-10 Bo Yang, Mengmeng Teng, Haisheng You, Yalin Dong, Siying Chen
Abstract Non-small-cell lung cancer (NSCLC) remains the most common malignant cancer. We identified 43140 advanced NSCLC patients from the SEER database to develop and validate a new prognostic model. The prognostic performance was evaluated by P value, concordance index, net reclassification index, integrated discrimination improvement, and decision curve analysis. The following variables were contained
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Neoadjuvant Therapy and Axillary Lymph Node Status in HER2-Positive Breast Cancer Cancer Investig. (IF 2.4) Pub Date : 2023-07-26 Sabine Danzinger, Christian Pfeifer, Sophia Wimmer, Kristina Tendl-Schulz, Christian F. Singer
Abstract Based on an estimating model, the aim of our study was to evaluate the axillary lymph node involvement of patients with primary invasive early human epidermal growth factor receptor 2 (HER2)-positive breast cancer before receiving neoadjuvant therapy (NAT). Patients with primary surgery (n = 63) were compared with patients who had received NAT (combined chemo/HER2-targeted antibody therapy)
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The Presence of Lung Cancer Affects SARS-CoV-2 Vaccine Uptake and Attitude in Chinese Patients: A Clinical Cross-Sectional Investigation Cancer Investig. (IF 2.4) Pub Date : 2023-07-27 Chen Chen, Ruili Pan, Liyuan Dai, Minjiang Chen, Jing Zhao, Wei Zhong, Mengzhao Wang, Hongsheng Liu, Yan Xu, Xiaohong Han
Abstract With the SARS-CoV-2 mutations evolving and prompt of SARS-CoV-2 vaccines, no information is available on SARS-CoV-2 vaccination status in Chinese patients with lung cancer. An electronic questionnaire including sociodemographic characteristics, vaccine status, side effect post-vaccination, and attitude towards a fourth dose of vaccine was conducted within 1018 Chinese patients with lung cancer
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In Vitro and In Vivo Synergistic Antitumor Activity of Albumin-Coated Oleic Acid-Loaded Liposomes toward Hepatocellular Carcinoma Cancer Investig. (IF 2.4) Pub Date : 2023-07-30 Esmail M. El-Fakharany, Mahmoud Ashry, Marwa M. Abu‑Serie, Khaled G. Abdel-Wahhab, Doaa Galal El-Sahra, Hamada El‑Gendi
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers, closely associated with cirrhosis and fibrosis. This study aimed to assess the antitumor activity of oleic acid-liposomes (uncoated liposomes) upon coating with albumin against HCC. The in vitro studies revealed the high safety of the prepared uncoated and albumin-coated liposomes to normal HFB-4 cells (EC100 of
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Perception, Cognition and Thought: Part III: Reasoning, Judgement and Decision-Making Cancer Investig. (IF 2.4) Pub Date : 2023-07-27 Gary H. Lyman, Nicole M. Kuderer
Published in Cancer Investigation (Vol. 41, No. 8, 2023)
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The Impact of Cancer-Associated Fibroblasts on Drug Resistance, Stemness, and Epithelial-Mesenchymal Transition in Bladder Cancer: A Comparison between Recurrent and Non-Recurrent Patient-Derived CAFs Cancer Investig. (IF 2.4) Pub Date : 2023-07-23 Nima Rastegar-Pouyani, Vahideh Montazeri, Nikoo Marandi, Shima Aliebrahimi, Melika Andalib, Emad Jafarzadeh, Hamed Montazeri, Seyed Nasser Ostad
Abstract This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered cell cycle distribution alongside induced resistance to apoptosis. Later, the scratch assay confirmed the cell migration-inducing effects of
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Perception, Cognition and Thought: Part II Symbolic Processing and Language Cancer Investig. (IF 2.4) Pub Date : 2023-07-11 Gary H. Lyman
Published in Cancer Investigation (Vol. 41, No. 7, 2023)
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The Democratization of Hematology-Oncology Medical Education during the COVID-19 Pandemic Cancer Investig. (IF 2.4) Pub Date : 2023-06-29 Samuel A. Kareff, Arthi Sridhar, Natasha Dhawan, Andrea Anampa-Guzmán, Eric K. Singhi, Ana I. Velazquez
Abstract Like many other aspects of hematology-oncology training, medical education experienced rapid changes throughout the COVID-19 pandemic that continue until today. We discuss some of the most transformative areas within medical education, including, but not limited to, educational philosophy; use of virtual resources; inter-institutional connections, shifts in clinical training; changes in recruitment
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Perception, Cognition and Thought: Part I Nature, Evolution and Development of Conceptual and Symbolic Processes Cancer Investig. (IF 2.4) Pub Date : 2023-06-28 Gary H. Lyman
Published in Cancer Investigation (Vol. 41, No. 6, 2023)
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The Utility of ctDNA in Lung Cancer Clinical Research and Practice: A Systematic Review and Meta-Analysis of Clinical Studies Cancer Investig. (IF 2.4) Pub Date : 2023-06-18 Xuezheng Sun, Page Abrahamson, Nicholas Ballew, Linda Kalilani, Kelesitse Phiri, Kelly F. Bell, Alexander Slowley, Magdalena Zajac, Erin Hofstatter, Alexander Stojadinovic, Angela Silvestro, Zebin Wang, Amine Aziez, Solange Peters
Abstract This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase database search, 111 studies from 2015 to 2020 demonstrated ctDNA’s value in prognostication/monitoring disease progression, mainly in patients with advanced/metastatic disease and non–small cell lung cancer. ctDNA
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Immunohistochemical Analysis of Lung Adenocarcinoma in Russian Mayak Nuclear Workers Cancer Investig. (IF 2.4) Pub Date : 2023-06-09 Gleb V. Sychugov, Tamara V. Azizova, Galina V. Zhuntova, Evgeniya S. Grigoryeva, Christopher A. Loffredo, Nobuyuki Hamada, Evgeniy L. Kazachkov
Abstract Specimens of lung adenocarcinoma (AdCa) from Russian nuclear workers (n = 54) exposed to alpha particles and gamma rays and from individuals non-exposed to radiation (n = 21) were examined using immunohistochemistry. Estimated significant associations with alpha dose were negative for Ki-67 and collagen IV in AdCa. Associations with gamma-ray dose were negative for tissue inhibitor of matrix
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Where the Sidewalk Ends: Parenting as a Trainee during COVID-19 Cancer Investig. (IF 2.4) Pub Date : 2023-06-09 Mazie Tsang, Rahul Banerjee, Dionisia Quiroga, Dame Idossa, Kelly L. Schoenbeck
Abstract Physicians who are also parents have faced significant difficulties during the COVID-19 pandemic. However, most studies of the physician-parent workforce have focused on the experiences of attending physicians. In this commentary, we highlight the ways that trainee parents have uniquely experienced three major stressors during the pandemic: (1) childcare challenges, (2) scheduling difficulties
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Outcomes of Cancer Patients with COVID-19: The Virginia Commonwealth University Experience Cancer Investig. (IF 2.4) Pub Date : 2023-06-05 Patrick J. Willard, Yiwei Hang, Temitayo Olasehinde, Naji Bou Zeid, Edem Defor, Dipankar Bandyopadhyay, Victor Yazbeck
Abstract Purpose The cancer population is significantly impacted by coronavirus disease 2019 (COVID-19) due to inherent risks of infection imposed by malignancy and therapeutic agents. Evaluating risk factors in this group will lead to improved guidelines for the treatment of malignancy in the setting of a COVID-19 pandemic. Patients and methods This retrospective study reviewed 295 inpatient cancer
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Smoking is Not Associated with Lung Metastasis in Pancreatic Cancer Cancer Investig. (IF 2.4) Pub Date : 2023-05-23 Michael S. May, Jacob K. Jamison, Winston Wong, Alissa Michel, Alexander G. Raufi, Alfred I. Neugut, Gulam A. Manji
Abstract Smoking is a risk factor for pulmonary metastasis in various malignancies. We investigated this association for pancreatic ductal adenocarcinoma (PDAC). We conducted a retrospective 1:2 case-control study of consecutive patients who underwent PDAC resection (2011–2021). Cases ultimately developed lung metastases and controls did not. Of 744 patients we identified 53 cases and 106 matched controls
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Integrative Analysis Developing and Validating Potential Candidate Biomarkers for Cancer Stemness Features of Pan-Renal Cell Carcinoma Cancer Investig. (IF 2.4) Pub Date : 2023-05-22 Fei Lin, Zhi-Bin Ke, Hang Chen, Wen-Cai Zheng, Ru-Nan Dong, Hai Cai, Xiao-Dong Li, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue, Shao-Hao Chen, Ning Xu
Abstract In our study, 49 key genes significantly associated with renal cell carcinoma (RCC) stemness were obtained. Next, we developed a molecular prognostic signature associated with stemness features of pan-RCC. The difference in overall survival (OS) between the high- and low-risk groups was statistically significant (p < .05). The area under the receiver operating characteristic curve for 1-year
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Bioinformatics Identification and Validation of Aging‑Related Molecular Subtype and Prognostic Signature in Sarcoma Cancer Investig. (IF 2.4) Pub Date : 2023-05-09 Xu Hong, Hui Liu, Chu Chen, Tian Lai, Jingui Lin
Abstract Aging could regulate many biological processes in malignancies by regulating cell senescence. Consensus cluster analysis was conducted to differentiate TCGA sarcoma cases. LASSO cox regression analysis was performed to construct an aging-related prognostic signature. We identified two categories of TCGA-sarcoma with significant difference in prognosis, immune infiltration and chemotherapy
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Gastrointestinal Stromal Tumor Patients with Molecular Testing Exhibit Superior Survival Compared to Patients without Testing: Results from the Life Raft Group (LRG) Registry Cancer Investig. (IF 2.4) Pub Date : 2023-05-04 Jerry Call, Jonathan Wojtkowiak, Denisse Evans, Pete Knox, Thomas J. Hughes, Maeven Luedke, Sahibjeet Kaur, Carolyn Tordella, Mary Garland, Paul T. Lim, Norman J. Scherzer, Sara Rothschild, Jonathan Trent
Abstract Mutational testing for Gastrointestinal Stromal Tumor (GIST) patients remains underutilized. In this retrospective analysis, the target population (n = 1556) reported: 904 had molecular testing (“Tested”) vs. 652 without testing (“Untested”). Overall survival (OS) was 14.7 vs. 12.7 years (p < 0.00001), in metastatic patients 1st line OS was 8.9 vs. 5.9 years in the Tested vs. Untested group
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Breaking Bad News in Cancer Patients: Voicing the Training Requirement Cancer Investig. (IF 2.4) Pub Date : 2023-05-04 Zahra Taheri, Seyed Alireza Javadinia, Ruhollah Ghahramani-Asl
Published in Cancer Investigation (Vol. 41, No. 6, 2023)
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The Value of Patient-Reported Outcomes in Single-Arm Cancer Trials Cancer Investig. (IF 2.4) Pub Date : 2023-05-02 Massimo Di Maio
Abstract Recently, many cancer drugs have been approved by regulatory agencies based on single-arm studies, where analysis of quality of life (QoL) and patient-reported outcomes (PROs) is not a direct comparison with the standard, but the simple description of changes versus baseline and trends over time. This analysis can be potentially biased by missing data: QoL level could be overestimated, and
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Chemotherapy-Induced Oral Complications and Prophylaxis Strategies Cancer Investig. (IF 2.4) Pub Date : 2023-04-20 Aleksandra Śledzińska, Paulina Śledzińska, Marek Bebyn, Oskar Komisarek
Abstract Cancer is currently a significant therapeutic challenge and is frequently connected with numerous adverse effects. Despite many improvements in chemotherapy, oral complications are common, leading to poor quality of life and chemotherapeutic dose reduction, which impair survival. This review summarizes the most common dental complications in patients receiving chemotherapy. We mainly focus