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Clinical implementation of three-dimensional standardized template-guided brachytherapy for patients with locally advanced cervical cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Yeqiang Tu, Jiahao Wang, Yukai Chen, Yuanyuan Chen, Qiu Tang
Purpose: Although customized three-dimensional (3D) templates have shown advantages in brachytherapy, widespread application is still full of challenges. The present work proposed the use of a commercial 3D standardized template-guided intracavitary/interstitial brachytherapy (IC/ISBT) that could provide simple and reproducible needles’ insertion. Material and methods: 43 patients received external
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Comparison of dosimetric analysis of organs at risk and target volumes for ovoids and cylinders in endometrial carcinoma J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Yashaswini BR, Tanvir Pasha, Rekha Reddy, Naveen T, Siddanna R Palled, Uday Krishna, Lokesh V, Sridhar P, Nikhila R, Thejaswini B, Chundru Swaroopa
Purpose: To compare dose volume parameters of target and organs at risk in vaginal vault brachytherapy using ovoids or cylinder in post-operative endometrial carcinoma. Material and methods: The study was done among 25 histologically proven post-operative endometrial carcinoma patients requiring vaginal brachytherapy. All patients underwent both cylinder and ovoids application alternatively on weekly
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Dosimetric impact of applying a model-based dose calculation algorithm for skin cancer brachytherapy (interventional radiotherapy) J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Elisa Placidi, Bruno Fionda, Enrico Rosa, Valentina Lancellotta, Antonio Napolitano, Martina De Angeli, Francesco Pastore, Maria Antonietta Gambacorta, Luca Indovina, Luca Tagliaferri, Marco De Spirito
Purpose: Brachytherapy (BT, interventional radiotherapy) is a well-established radiotherapy technique capable of delivering high doses to tumors while sparing organs at risk (OARs). Currently, the clinically accepted dose calculation algorithm used is TG-43. In the TG-186 report, new model-based dose calculation algorithms (MBDCA), such as Elekta’s advanced collapsed cone engine (ACE), have been introduced
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Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Madoka Sakuramachi, Naoya Murakami, Ayaka Nagao, Kanako Kojima, Yusaku Miyata, Tairo Kashihara, Tomoya Kaneda, Kana Takahashi, Koji Inaba, Kae Okuma, Yuko Nakayama, Hiroyuki Okamoto, Mitsuya Ishikawa, Hiroshi Igaki
Purpose: The use of a hydrogel spacer inserted into recto-vaginal fossa is a valuable strategy to mitigate radiation exposure to the rectum during radiation therapy for female pelvic malignancies. However, when the sigmoid colon is in proximity to the cervix, radiation exposure to the sigmoid colon cannot be adequately mitigated with a hydrogel spacer injected into the recto-vaginal fossa. Here, we
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Current status and future readiness of Indian radiation oncologists to embrace prostate high-dose-rate brachytherapy: An Indian Brachytherapy Society survey J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Susovan Banerjee, Soumya Sarkar, Umesh Mahantshetty, Sorun Shishak, Venkatesan Kaliyaperumal, Shyam Singh Bisht, Deepak Gupta, Kushal Narang, Mayur Mayank, V Srinivasan, Vivek Anand, Kanhu Charan Patro, Rajiv Ranjan Prasad, Tejinder Kataria
Purpose: This survey aimed to understand the practice pattern and attitude of Indian doctors towards prostate brachytherapy. Material and methods: A 21-point questionnaire was designed in Google form and sent to radiation oncologists practicing in India, using texts, mails, and social media. Responses were collated, and descriptive statistical analysis was performed. Results: A total of 212 radiation
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Clinical outcomes of single application multi-fractionated CT-guided interstitial high-dose-rate brachytherapy for locally advanced cervical cancer: A multi-institution initial experience J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Eugene T Yap, Mark P Dumago, Carl Jay Jainar, Maureen Bojador, Stellar Marie Cabrera, Gil S Gonzalez, Jocelyn Z Mariano, Aida Bautista, Jhustine Mababangloob, Janell Marie Genson, Teresa Sy Ortin, Warren R Bacorro
Purpose: The aim of the study was to evaluate the safety and clinical outcomes of single application multi-fractionated computed tomography (CT)-guided interstitial high-dose-rate brachytherapy given in four fractions in locally advanced cervical cancer. Material and methods: Patients with locally advanced cervical cancer stage IIB-IVA treated definitively with external radiation ± weekly cisplatin
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Clinical efficacy analysis of radioactive 125I particle implantation for the treatment of pelvic local recurrence of cervical cancer after radiotherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-29 Liqiu Ji, Wenwen Zhang, Shanhu Hao, Zhiguo Wang, Guoxu Zhang
Purpose: To explore the efficacy of CT-guided iodine-125 (125I) radioactive particle implantation for the treatment of pelvic local recurrence of cervical cancer after radiotherapy. Material and methods: To analyze clinical data of 46 patients with pelvic local recurrence of cervical cancer after radiotherapy, who underwent 125I particle implantation, post-operative follow-up using Kaplan-Meier method
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The Montreal split ring applicator: Towards highly adaptive gynecological brachytherapy using 3D-printed biocompatible patient-specific interstitial caps J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-12 Yuji Kamio, Marie-Ève Roy, Lori-Anne Morgan, Maroie Barkati, Marie-Claude Beauchemin, François DeBlois, Borko Basaric, Jean-François Carrier, Stéphane Bedwani
Purpose: The addition of interstitial (IS) needles to intra-cavitary (IC) brachytherapy applicators is associated with improved outcomes in locally advanced cervical cancers involving parametrial tumor extensions. The purpose of this work was to validate a clinical workflow involving 3D-printed caps for a commercial IC split ring applicator that enable using IS needle trajectories tailored to each
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Quantifying the effect of eccentric ruthenium plaque placement on tumor volume dose J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-12-09 Jeremy P. M. Flanagan, William H. F. Udovenya, Melvin A. Astrahan, Daniel McKay, Claire Phillips, John D. McKenzie, Roderick O’Day, Lotte S. Fog
Purpose: Ruthenium-106 brachytherapy is a common treatment for small to medium-sized uveal melanomas. In certain clinical contexts, plaques may be placed eccentrically to tumor center. The effect of plaque decentration, a common radiation dose measurement in radiotherapy: D98%, the percentage of the tumor volume receiving at least 98% of the prescribed dose (a commonly used term in radiation oncology)
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3D-printed vaginal cylindrical template with curved needle channels in MRI-guided vaginal cuff brachytherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-11-25 Zhuang Mao, Hongfu Zhao
Purpose: To present a new technique for the treatment of vaginal cuff recurrences using 3D-printed vaginal cylindrical template (3D-PVCT) with curved needle channels in brachytherapy. Material and methods: Two patients with vaginal cuff tumor treated with external beam radiotherapy and MRI-guided interstitial brachytherapy were selected for the present study. Prior to treatment, a vaginal cylinder
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Simple fabrication technique of personalized endocavitary brachytherapy applicator for maxillary alveolar cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-11-20 Warren Bacorro, Janell Marie Genson, Audri Joelle Dueñas, Henri Cartier Co, Antonio Villalon, Alfredo Pontejos
Purpose: We report on methods and outcomes of post-operative endocavitary brachytherapy after prior irradiation and salvage surgery in a patient with maxillary alveolar squamous cell carcinoma (SCC). Material and methods: A 67-year-old male with right maxillary alveolar SCC was referred for brachytherapy after prior definitive chemoradiotherapy and salvage posterior maxillectomy. A personalized endocavitary
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Dosimetry and plan parameters study of three-dimensional-printed template-based intra-cavitary/interstitial interpolation technology using computed tomography-guided high-dose-rate brachytherapy in locally advanced cervical cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-31 Baoxi Liu, Yaqin Wu, Li Sun, Chang Guo, Qi Wang, Zhongde Mu
Purpose: To explore differences in dosimetry and planning parameters between intra-cavitary/interstitial interpolation (IC + ISBT) three-dimensional (3D)-printed template-based (3D-printed) and simple intra-cavity (ICBT) radiation techniques using a fixed Rotterdam three-tube applicator (TT) for computed tomography-guided high-dose-rate brachytherapy in locally advanced cervical cancer. Material and
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Dosimetric impact of applicator displacement on three-dimensional image-guided high-dose-rate brachytherapy treatments for cervical cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-31 Sandun Jayarathna, Matthew Hoang, Rajeev Badkul, Andrew Hoover
Purpose: To determine the dosimetric impact of brachytherapy applicator displacement during intracavitary (IC) and combined intracavitary/interstitial (IC/IS) high-dose-rate brachytherapy in the treatment of cervical cancer. Material and methods: Data from 27 consecutively treated patients undergoing IC or IC/IS high-dose-rate brachytherapy with tandem and ovoid-based applicators at a single academic
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A study comparing baseline and best-corrected visual acuity after iodine-125 episcleral brachytherapy in uveal melanoma J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-31 David Miguel, Jesús María de Frutos, Pilar Alonso, Ciro García-Álvarez, María Antonia Saornil, Patricia Diezhandino, Maria Isabel Garavis, Patricia Valencia
Purpose: The aim of this study was to analyze the course of visual acuity (VA) in visual outcomes of patients treated with iodine-125 (125I) brachytherapy in our center, based on original VA before treatment. Material and methods: Visual acuity was prospectively assessed using a case series of 305 patients treated with 125I between 1996 and 2022. To examine how VA behaves over time, we divided patient
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The role of interventional radiotherapy (brachytherapy) in nasopharynx tumors: A systematic review J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-30 Roberto Milazzotto, Valentina Lancellotta, Alessandro Posa, Bruno Fionda, Mariangela Massaccesi, Patrizia Cornacchione, Corrado Spatola, György Kovács, Alessio Giuseppe Morganti, Francesco Bussu, Vincenzo Valentini, Roberto Iezzi, Luca Tagliaferri
Purpose: Nasopharyngeal cancers (NPC) are very aggressive, and the recurrence rate after radical therapy is high. This study aimed to evaluate the efficacy of brachytherapy (BT) also called interventional radiotherapy (IRT) in primary NPC in comparison with external beam radiotherapy (EBRT) alone. Material and methods: A systematic search was performed in Scopus, Cochrane, and PubMed databases. Clinical
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Combination of image-guided IMRT and IGBT in locally advanced carcinoma cervix: Prospective evaluation of toxicities and clinical outcomes from a tertiary cancer center in India J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-30 Vachaspati Kumar Mishra, Madhup Rastogi, Ajeet Gandhi, Rohini Khurana, Rahat Hadi, Shantanu Sapru, Surendra Mishra, Anoop Kumar Srivastava, Neetu Singh
Purpose: We aimed to assess the toxicity profile and clinical outcome in patients with locally advanced cervical cancer (LACC) treated with a combination of image-guided intensity-modulated radiation therapy (IG-IMRT) and image-guided brachytherapy (IGBT). Material and methods: 25 LACC patients were recruited in this single-arm prospective study. Whole pelvis IG-IMRT was delivered (45 Gy with simultaneously
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Analysis of source dwell position during treatment in brachytherapy using CT scout images J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-30 Nozomi Nakajima, Tomonori Isobe, Yoshinobu Furuyama, Tetsuya Tomita, Daisuke Kobayashi, Yutaro Mori, Hideyuki Takei, Yoshiaki Nagai, Yasuwo Ide, Keiko Nemoto Murofushi, Masaru Nakajima, Yasuo Yoshioka
Purpose: Several cases of inaccurate irradiation in brachytherapy have been reported, occurring similarly to external radiation. Due to a large dose per fraction in brachytherapy, inaccurate irradiation can seriously harm a patient. Although various studies have been conducted, systems that detect inaccurate irradiation in brachytherapy are not as developed as those for external irradiation. This study
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Ruthenium brachytherapy for iris melanoma J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-26 Emilia Zwolińska, Lidia Główka, Adam Chicheł, Iwona Rospond-Kubiak
Purpose: The study aimed to review the long-term outcomes of ruthenium brachytherapy for iris and iridociliary melanoma. Material and methods: Medical records of patients who underwent ruthenium plaque treatment for iris and iridociliary melanoma at the Department of Ophthalmology, Poznań University of Medical Sciences, between 1999 and 2021 were retrospectively reviewed. Results: We identified 24
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Radiation retinopathy following episcleral brachytherapy for intraocular tumors: Current treatment options J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-26 Weronika Mularska, Adam Chicheł, Iwona Rospond-Kubiak
Radiation retinopathy (RR) and radiation maculopathy (RM) can occur as a result of uveal melanoma radiation treatment and after irradiation of other head and neck extraocular tumors, even with precise targeting techniques, such as stereotactic or proton beam radiotherapy. This review provides an overview of the current understanding of potential radiation damage to ocular tissues, and how recent developments
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Five-year disease-free survival in FIGO IA stage endometrial cancer patients: Tertiary institution experience in a developing country J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-19 Marija Živković Radojević, Srđan Mujković, Protrka Zoran, Dragan Lončar, Nikola Nedović, Jasmina Nedović, Radiša Vojinović, Aleksandra Dimitrijević, Tatjana Vulović, Neda Milosavljević
Purpose: Endometrial cancer is characterized as histopathological, molecular, genetic, biological, and very diverse group of malignancies. Due to the need to precisely define the indications for adjuvant treatment in recent years, there has been a division made according to risk groups based on prognostic factors, which identify patients at risk for disease relapse, who may benefit from adjuvant therapy
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First application of GammaTile cesium-131 brachytherapy with maximal safe resection of a glioma in a patient with limited scleroderma J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-13 Melisa Pasli, Sara Cowles, Jasmin Jo, Mahmoud Yaqoub, Hilal A. Kanaan, Andrew W. Ju, Sean Peach
The purpose of this report is to present the first documented application of GammaTile to an intra-cranial tumor of a patient with a symptomatic radiosensitive connective tissue disorder, a case where there were significant concerns with standard oncologic strategies. We hypothesized that GammaTile® (GT Medical Technologies, Tempe, Arizona, USA) would also be advantageous in the application of intra-cranial
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Assessment of dose to vaginal mucosa for gynecologic template interstitial high-dose-rate brachytherapy using Monte Carlo simulation J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-10-03 Devin Van Elburg, Tyler Meyer, Kevin Martell, Sarah Quirk, Michael Roumeliotis
Purpose: This study investigated reliable vaginal mucosa dose-volume histogram (DVH) metrics in gynecologic template interstitial high-dose-rate brachytherapy (HDR-BT) for the purpose of standardized dose reporting. Material and methods: Gynecologic template (Syed/Neblett) interstitial HDR-BT patients treated from September 2016 to November 2022 at the study institute were included in the cohort. Each
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The role of training simulators in interventional radiation therapy (brachytherapy) training: A narrative review J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-31 Martina Ferioli, Federica Medici, Erika Galietta, Ludovica Forlani, Luca Tagliaferri, Savino Cilla, Silvia Cammelli, Alessio G. Morganti, Milly Buwenge
Simulators have revolutionized medical education and training across various disciplines, offering unique advantages in skill acquisition and performance improvement. In the context of interventional radiation therapy (IRT), simulators have emerged as valuable tools for training healthcare professionals in these complex procedures. This narrative review summarized the available evidence on the use
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Inter-observer variation of target volume delineation for CT-guided cervical cancer brachytherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-31 Aysenur Elmali, Fatih Biltekin, Sezin Sari, Melis Gultekin, Deniz Yuce, Ferah Yildiz
Purpose: Delineation is a critical and challenging step in radiotherapy planning. Differences in delineation among observers are common, despite the presence of contouring guidelines. This study aimed to identify the inter-observer variability in the target volume delineation of computed tomography (CT)-guided brachytherapy for cervical cancer. Material and methods: Four radiation oncologists (ROs)
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Evaluation of doses to pelvic lymph node regions from image-guided high-dose-rate interstitial brachytherapy for carcinoma of the uterine cervix J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-31 Ajeet Gandhi, Madhup Rastogi, Vachaspati Kumar Mishra, Anoop Kumar Srivastava, Farhana Khatoon, Daya Nand Sharma
Introduction: Interstitial brachytherapy (ISBT) is indicated for intact cervical carcinoma (IN-CC) if intracavitary brachytherapy (ICRT) is not feasible and also in vault carcinoma (VA-C). We aimed to evaluate the doses to pelvic lymph node regions in IN-CC and VA-C treated with ISBT. Material and methods: Ten patients (6 IN-CC, 4 VA-C) were chosen for this dosimetric study. IN-CC had a central tandem
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The application of 3D brachytherapy in cervical stump cancer: A retrospective study J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-31 Yuxuan Wang, Xue Qin Wang, Lang Yu, Xiaorong Hou, Ke Hu, Junfang Yan, Fuquan Zhang
Purpose: Cervical stump cancer is a carcinoma that grows on the cervical stump after a sub-total hysterectomy. There have been no studies on the application of 3D brachytherapy in cervical stump cancer. In the present study, we aimed to compare the curative effects, toxicity, and dosimetry of 3D and 2D brachytherapy in cervical stump cancer. Material and methods: Thirty-one patients admitted between
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TACE combined with portal particle implantation in a case of stage IIIa primary hepatocellular carcinoma treated with sequential anlotinib J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-31 Cheng Lin, Chen Chen, Guiliu Huang, Yueyong Li, Lifeng Zhao, Zhongheng Wei
Few cases of patients with Cheng’s type III portal vein tumor thrombus (PVTT) have been reported to achieve radical cure without recurrence over time. In this study, we reported on a 55-year-old male patient with a diagnosis of stage IIIa China liver cancer staging (CNLC), PVTT Cheng’s type III, mild cirrhosis, and chronic viral hepatitis B. TACE combined with radioactive iodine-125 (125I) particle
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Oncologic outcomes after MRI-assisted image-guided brachytherapy with hybrid interstitial and intra-cavitary applicators under moderate sedation for locally advanced cervix cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-30 Kiattisa Sommat, Swee Peng Yap, Richard Ming Chert Yeo, Hoon Seng Khoo Tan, Yoke Lim Soong, Jeffrey Kit Loong Tuan, Iris Huili Sin
Purpose: To report outcomes of using image-guided hybrid intra-cavitary/interstitial applicators under moderate sedation for locally advanced cervical cancer patients in our institution. Material and methods: A total of 69 fractions of brachytherapy with hybrid applicators were performed in 33 patients from January 2017 to April 2021. All patients underwent MRI pelvis 1 week pre-brachytherapy to determine
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Dosimetric comparison of rectal dose-reductive techniques in intra-cavitary brachytherapy for cervical cancer: A retrospective analysis J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-30 Masafumi Sawada, Yutaka Shiraishi, Hirofumi Toyama, Tomoki Tanaka, Ryuichi Kota, Naoyuki Shigematsu
Purpose: Rectal complications in radiotherapy for cervical cancer can highly affect quality of life and correlate with rectal dose. Vaginal gauze packing (VP) and rectal retraction (RR) are widely used for rectal dose reduction in high-dose-rate brachytherapy. We aimed to perform a dosimetric comparison of these two methods for three-dimensional image-guided adaptive brachytherapy. Material and methods:
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Advanced non-melanoma skin cancer in elderly patients: When surgery says NO, interventional radiotherapy (brachytherapy) says YES J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-08-24 Adam Chicheł, Artur J. Chyrek, Adam Kluska, Wojciech M. Burchardt
Purpose: The prevalence of non-melanoma skin cancer (NMSC) increases, especially in older adults with comorbidities, narrowing radical treatment options. About 5% of skin cancer patients are diagnosed with an advanced stage, which impairs daily functioning. The study was to present a retrospective summary of elderly patients unfit for surgery and treated with various brachytherapy (BT) techniques tailored
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Three-dimensional template combined with MR-guided iodine-125 brachytherapy for recurrent brain metastases J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-30 Xiangmeng He, Yujun Xu, Ming Liu, Jing Fang, Kai Zhang, Xiaotong Guo, Xingchang Yan, Chengli Li
Purpose: Treatment of recurrent brain metastases is extremely challenging. Here, we evaluated the feasibility and efficacy of an individualized three-dimensional template combined with MR-guided iodine-125 (125I) brachytherapy in the treatment of recurrent brain metastases. Material and methods: Twenty-eight patients with recurrent 38 brain metastases underwent 125I brachytherapy from December, 2017
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Interstitial brachytherapy for internal mammary node in breast cancer: A case report J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-27 Subhas Pandit, Simit Sapkota, Sundar Suwal, Abish Adhikari, Prakriti Karki, Anjani Kumar
This case study reports the feasibility, safety, and efficacy of interstitial brachytherapy for internal mammary nodal recurrence in a 68-year-old woman with triple-negative breast cancer. The patient had previously undergone mastectomy followed by chemotherapy and radiotherapy. However, an internal mammary node was discovered during a routine follow-up a year later, which was confirmed as metastatic
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Ophthalmic applicator displacement as a method of treating large diffuse uveal melanomas J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-26 Anna Markiewicz, Konrad Skórkiewicz, Agata Bogdał, Dominik Medoń, Mirella Świder, Elżbieta Korab-Chrzanowska, Joanna Kowal, Magdalena Dębicka-Kumela, Bożena Romanowska-Dixon
Purpose: The presentation of results of an ophthalmic plaque displacement as a brachytherapy treatment method of large diffuse uveal melanomas. Material and methods: This was a retrospective analysis of treatment results of 9 patients with large diffuse uveal melanomas using ophthalmic plaque displacement. Patients were treated with this method in our center between 2012 and 2021 (last follow-up visit
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Comparative analysis of dosimetric and radiobiological models of IPSA and HIPO algorithms in combined intra-cavitary/interstitial brachytherapy for cervical cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-23 Chuanjun Yan, Xianliang Wang, Aiping Wen, Jingyue Luo, Siyu Zhang, Pei Wang, Jie Li
Purpose: To compare inverse planning simulated annealing (IPSA) and hybrid inverse planning optimization (HIPO) using dosimetric and radiobiological models, and provide a basis for selecting the optimization method for cervical cancer. Material and methods: This was a retrospective study including 32 patients with radical cervical cancer. Brachytherapy treatment plans were re-optimized using IPSA,
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Initial tumor volume as an important predictor for indication of intra-cavitary brachytherapy, intra-cavitary/interstitial brachytherapy, and multi-catheter sole interstitial brachytherapy in cervical cancer patients treated with chemoradiotherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-23 Tadashi Takenaka, Hideya Yamazaki, Gen Suzuki, Koji Masui, Daisuke Shimizu, Tadayuki Kotsuma, Eiichi Tanaka, Ken Yoshida, Kei Yamada
Purpose: Advances in three-dimensional image-guided brachytherapy technique allow for using intra-cavitary, intra-cavitary and interstitial brachytherapy (ICIS-BT), and sole interstitial brachytherapy (ISBT) in addition to conventional intra-cavitary brachytherapy (ICBT). However, no consensus has been reached regarding the choice of these techniques. The aim of this study was to propose the size criteria
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Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-21 Tamer Soror, Corrina Melchert, Dirk Rades, Axel S. Merseburger, György Kovács
Purpose: To report the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for macroscopic histologically confirmed local relapse of prostatic cancer after prostatectomy and subsequent external irradiation. Material and methods: A retrospective study of patients with prostate adenocarcinoma, treated with HDR-IRT for an isolated local relapse after prostatectomy
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Intra-luminal iodine-125 brachytherapy in patients with esophageal carcinoma and 3/4 dysphagia score: A feasibility study J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-01 Kaihao Xu, Chuan Tian, Yahua Li, Yiming Liu, Jianzhuang Ren, Xinwei Han, Dechao Jiao
Purpose: To evaluate the clinical results of nasal feeding nutritional tube (NFNT)-loaded iodine-125 (125I) seeds in intra-luminal brachytherapy (ILBT) for esophageal carcinoma (EC) patients with a 3/4 dysphagia score. Material and methods: From January 2019 to January 2020, 26 patients (female/male: 17/9, mean age: 75.3 years, dysphagia score 3/4: 6/20, mean Karnofsky score: 58.4) with EC underwent
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Changes in receipt of adjuvant brachytherapy for endometrial cancer patients before and after affordable care act: The impact of Medicaid expansion J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-01 Amy Le, Jordan A. Holmes
Purpose: For patients with high-intermediate risk (HIR) endometrial cancer, adjuvant radiation (RT) reduces the risk of recurrence, but many patients do not receive RT. Under the Affordable Care Act (ACA), most states expanded Medicaid coverage. Our hypothesis was patients would be more likely to receive indicated adjuvant RT in states that expanded Medicaid compared with patients in states that did
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Multilayer intensity modulated contact interventional radiotherapy (brachytherapy): Stretching the therapeutic window in skin cancer J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-06-01 Bruno Fionda, Elisa Placidi, Enrico Rosa, Valentina Lancellotta, Gerardina Stimato, Martina De Angeli, Francesco Giuseppe Ciardo, Patrizia Cornacchione, Frank-Andre Siebert, Luca Tagliaferri, Luca Indovina
Interventional radiotherapy (IRT, brachytherapy) is a highly effective treatment method for non-melanoma skin cancer (NMSC). Traditionally, the maximum depth of NMSC lesions considered eligible for contact IRT was 5 mm; however, following several national surveys and recent recommendations, such cut-off, lesions thicker than 5 mm may be treated by contact IRT. The use of image guidance in defining
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Trans-rectal ultrasound-guided hybrid intra-cavitary and interstitial brachytherapy in carcinoma cervix: A feasibility study from a tertiary cancer center in India J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-05-31 Harjot Kaur Bajwa, Rohith Singareddy, Anil Kumar Talluri, Heena Kauser, Devender Reddy Boja, G Srikanth, Alluri Krishnam Raju, Madhusudhana Sresty, Vyshnavi Mytri
Purpose: To report the feasibility of performing hybrid intra-cavitary and interstitial (IC/IS) brachytherapy in patients with carcinoma cervix under trans-rectal ultrasound (TRUS) guidance. Material and methods: All patients who received an external beam radiotherapy (EBRT) dose of 50 Gy in 25 fractions with weekly chemotherapy, followed by a brachytherapy boost (21 Gy in 3 fractions) were prospectively
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A case of dermatofibrosarcoma protuberans of the scalp treated with surface mould brachytherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-05-31 Raj Hans, Sankalp Singh, Prince Arvind, Arti Sarin, Manoj K. Semwal, Pankaj Vats
Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive soft tissue tumor with a high propensity of local recurrence after surgery. Radiotherapy as an adjuvant therapy has been shown to reduce recurrent rates of this disease. Surface mould brachytherapy is an effective and safe modality for the delivery of radiotherapy in soft tissue tumors, though its utilization and popularity have decreased
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Impact of age on the Quadrella index assessing oncological and functional results after prostate brachytherapy: A 6-year analysis J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-28 Guillaume Tremblay, Truong An Nguyen, Julien Marolleau, Jean-Pierre Malhaire, Alexandre Fourcade, Nicolas Boussion, Gaelle Goasduff, Emmanuelle Martin, Gurvan Dissaux, Olivier Pradier, G Fournier, U Schick, Antoine Valeri
Purpose: As the oncological results of prostate brachytherapy (BT) are excellent for low-risk (LR) or favorable intermediate-risk (FIR) prostate cancer (PCa), evaluating the side effects has become a major issue, especially for young men. The objective of the study was to compare the oncologic and functional results of BT using Quadrella index for patients aged 60 or less compared with older patients
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Quality of life of muscle-invasive bladder cancer patients after brachytherapy-based treatment: A cross-sectional study J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-28 Danique A. Scheltes, Elzbieta M. van der Steen-Banasik, Geert A.H.J. Smits
Purpose: To determine the quality of life (QoL) of patients with muscle-invasive bladder cancer (MIBC) who underwent bladder-sparing treatment with high-dose-rate brachytherapy, and compare their QoL with an age-matched general Dutch population. Material and methods: We conducted a single-center, prospective, descriptive cross-sectional study. MIBC patients who underwent brachytherapy-based bladder
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Complication and response assessment of high-dose-rate endorectal brachytherapy boost in neo-adjuvant chemoradiotherapy of locally advanced rectal cancer with long-term outcomes J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-28 Arefeh Saeedian, Marzieh Lashkari, Reza Ghalehtaki, Maryam Taherioun, Mahdieh Razmkhah, Ali Kazemian, Mahdi Aghili
Purpose: To identify efficacy, complication, and pathologic response of high-dose-rate endorectal brachytherapy (HDR-BRT) boost in neo-adjuvant chemoradiotherapy (nCRT) of locally advanced rectal cancer. Material and methods: Forty-four patients who met eligibility criteria were included in this non-randomized comparative study. Control group was recruited retrospectively. nCRT (50.40 Gy/28 fr. plus
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Variations and effects of bladder and rectal volume following uniform preparation procedure in cervical cancer: Five fractions of 6 Gy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-28 Bin-Qiang Ye, Cheng-Zong Zhao, Peng-Fei Sun
Purpose: To analyze the effects of different bladder and rectal volumes on the dose of organ at risks (OARs) and primary tumors following uniform preparation procedure. Material and methods: In this retrospective study, a total of 60 patients with cervical cancer treated with external beam radiation therapy (EBRT) combined with chemotherapy and brachytherapy (BT) during 2019-2022 were included (300
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Intra-operative interstitial brachytherapy in a novel infra-zygomatic approach for partially resectable head and neck cancers around the base of skull: A technical note J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-21 Siddanna R Palled, Jaswanthi Akkpatti Ramachandra Reddy, Purushottam Chavan, Siddappa K, Sunil RA, Sanjeet Kumar Mondal, Bindu Krishnappa Venugopal, V Lokesh
Purpose: To report an intra-operative catheter insertion technique into the base of skull tumor bed following surgical resection for maxillary tumors. Material and methods: A 42-year-old male patient diagnosed with carcinoma of the maxilla was treated with neoadjuvant chemotherapy followed by chemo-radiation using external beam technique combined with brachytherapy boost to post-operative bed. Brachytherapy
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The potential of low-dose-rate brachytherapy with iodine-125 in the treatment of local recurrences of prostate cancer after primary high-dose-rate monotherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-12 Wojciech M. Burchardt, Artur J. Chyrek, Grzegorz M. Bielęda, Ewa Burchardt, Adam Chicheł
Purpose: The incidence of local prostate cancer recurrences after monotherapy with high-dose-rate brachytherapy (HDR-BT) is low. However, a cumulated number of local recurrences during follow-up is naturally observed in highly specialized oncological centers. This retrospective study aimed to present the treatment of local recurrences after HDR-BT with low-dose-rate brachytherapy (LDR-BT). Material
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Automatic reconstruction of interstitial needles using CT images in post-operative cervical cancer brachytherapy based on deep learning J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-06 Hongling Xie, Jiahao Wang, Yuanyuan Chen, Yeqiang Tu, Yukai Chen, Yadong Zhao, Pengfei Zhou, Shichun Wang, Zhixin Bai, Qiu Tang
Purpose: The purpose of this study was to investigate the precision of deep learning (DL)-based auto-reconstruction in localizing interstitial needles in post-operative cervical cancer brachytherapy (BT) using three-dimensional (3D) computed tomography (CT) images. Material and methods: A convolutional neural network (CNN) was developed and presented for automatic reconstruction of interstitial needles
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An audit of uterine perforation and its’ effect on the final outcome in an academic research medical center: An optimized balance between overall treatment time and medical crisis J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-04-04 Mrinalini Verma, Divya Kukreja, Arunima Ghosh, Puja Kumari, Ajay KV, Kirti Srivastava
Introduction: Intra-cavitary brachytherapy is an integral component of cervical cancer management, and uterine perforation is the most significant complication, which may lead to prolonged overall treatment time and decreased local control in these patients. Material and methods: A retrospective analysis of cervical cancer patients who completed radiotherapy (external beam radiotherapy and brachytherapy)
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Validation of the bladder neck as an important organ at risk in prostate seed brachytherapy based on D2cc: A single-institution, retrospective review J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-03-30 Neil D. Wallace, Karen L. Olden, Victoria S. Brennan, Mohd Mat Samuji, Muhammad Faisal Jamaluddin, Gerard McVey, Mary T. Dunne, Paul J. Kelly
Purpose: International guidelines recommend urethral dose volume constraints to minimize the risk of urinary toxicity after prostate brachytherapy. An association between dose to the bladder neck (BN) and toxicity has previously been reported, and we sought to evaluate the impact of this organ at risk on urinary toxicity, based on intra-operative contouring. Material and methods: Rates of acute and
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Dosimetric comparison between microSelectron iridium-192 and flexi cobalt-60 sources in high-dose-rate brachytherapy using Geant4 Monte Carlo code J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-03-29 Tsige Yhidego Gebremariam, Ghazale Geraily, Hussam Hameed Jassim, Somayeh Gholami
Purpose: Manufacturing of miniaturized high activity iridium-192 (192Ir) sources have been made a market preference in modern brachytherapy. Smaller dimensions of the sources are flexible for smaller diameter of the applicators, and it is also suitable for interstitial implants. Presently, cobalt-60 (60Co) sources have been commercialized as an alternative to 192Ir sources for high-dose-rate (HDR)
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Focal salvage high-dose-rate brachytherapy with implantable rectum spacer for locally recurrent prostate cancer after initial low-dose-rate with grade 3 rectal toxicity J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-03-22 Thirza Opbroek, Anne Cobussen, Evert J. Van Limbergen, Ben G.L. Vanneste
Purpose: Locally recurrent prostate cancer after previous radiation therapy remains challenging. One of the curative options for these patients is salvage brachytherapy. There are no reports available on the use of a biodegradable rectal balloon implantation (RBI) in combination with brachytherapy in patients with recurrent prostate cancer after previous radiotherapy. Case presentation: Here, we report
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Pain and symptom relief using inhaled methoxyflurane for gynecologic brachytherapy applicator removal J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-03-12 Alexandra J. Stewart, Ciarna Brooker, Gemma Vose, Katie Redmond, Amy Williams, Nikesh Pankhania, Hayley Dommett, Justin Kirk-Bayley, Adrian P. Franklin, Ben Morrison
Purpose: Intra-cavitary brachytherapy forms an essential part of the curative treatment of cervical and vaginal cancer, and can be used for cure or palliation in endometrial and vulval cancers. Removal of brachytherapy applicators is often performed after anaesthesia has worn off and can be an uncomfortable and anxiety-provoking procedure. In this paper, we present our experience in a series of patients
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Technical details and clinical outcomes after high-dose-rate intracavitary brachytherapy for squamous cell carcinoma of external auditory canal and external beam radiotherapy for nodal coverage: A case report J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Mark P. Dumago, Kelvin Ken L. Yu, Luisa E. Jacomina, Eugene T. Yap, Carl Jay E. Jainar, Maureen R. Bojador, Adrian F. Fernando, Warren R. Bacorro, Michael A. Mejia
Introduction: To report technical details and 15-month outcomes of a patient with node-positive external auditory canal (EAC) squamous cell carcinoma (SCC) treated with definitive intracavitary high-dose-rate (HDR) brachytherapy to primary tumor, and external beam radiotherapy (EBRT) to draining lymphatics. Material and methods: A 21-year-old male was diagnosed with SCC of the right EAC. The patient
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HDR-brachytherapy for accelerated partial breast irradiation: Long-term experience from a Japanese institution J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Ken Yoshida, Tadayuki Kotsuma, Yuji Takaoka, Setsuo Tamenaga, Hideya Yamazaki, Takayuki Nose, Naoya Murakami, Koji Inaba, Hironori Akiyama, Koji Masui, Tadashi Takenaka, Hikaru Kubota, Nikolaos Tselis, Norikazu Masuda, Hiroyuki Yasojima, Masashi Takeda, Masayuki Mano, Satoaki Nakamura, Keita Utsunomiya, Noboru Tanigawa, Eiichi Tanaka
Purpose: We investigated the long-term oncological outcome of high-dose-rate (HDR) multicatheter interstitial brachytherapy (MIB) for adjuvant accelerated partial breast irradiation (APBI) after breast conserving surgery in Japanese patients. Material and methods: Between June 2002 and October 2011, 86 breast cancer patients were treated at National Hospital Organization Osaka National Hospital (trial
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Long-term clinical outcomes of non-melanoma skin cancer patients treated with electronic brachytherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Stephen W. Doggett, Mark Willoughby, Kenneth A. Miller, Erick Mafong
Purpose: High-dose-rate electronic brachytherapy (eBx) is a non-surgical treatment option for non-melanoma skin cancer (NMSC) patients. This study assessed long-term effectiveness and safety of eBx for the treatment of NMSC. Material and methods: A chart review was conducted to identify subjects who had five or more years since their last eBx treatment fraction. Subjects meeting these criteria were
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Combined CT-guided high-dose-rate brachytherapy (CT-HDRBT) and transarterial chemoembolization with irinotecan-loaded microspheres improve local tumor control and progression-free survival in patients with unresectable colorectal liver metastases compared with mono-CT-HDRBT J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Stefanie Friedrich, Felix Busch, Martin Jonczyk, Gero Wieners, Georg Böning, Willie Magnus Lüdemann, Aymen Meddeb, Federico Collettini, Bernhard Gebauer
Introduction: To compare the effectivity and toxicity of monotherapy with computed tomography-guided high-dose-rate brachytherapy (CT-HDRBT) vs. combination therapy of transarterial chemoembolization with irinotecan (irinotecan-TACE) and CT-HDRBT in patients with large unresectable colorectal liver metastases (CRLM) with a diameter of > 3 cm. Material and methods: Forty-four retrospectively matched
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Feasibility of outpatient hybrid brachytherapy for cervical cancer with minimal sedation: Results from a single-institutional protocol J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Subhakar Mutyala, Gabriella Smith, Hayden Ansinelli, Nitika Thawani
Purpose: Pain control techniques during high-dose-rate hybrid intracavitary-interstitial brachytherapy (HBT) for cervical cancer vary widely, with many centers opting for general anesthesia (GA) or conscious sedation (CS). Here, we describe a single-institutional series of patients treated with HBT and ASA-defined minimal sedation, utilizing oral analgesic and anxiolytic medications in substitution
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Iodine-125 seed brachytherapy combined with pembrolizumab for advanced non-small-cell lung cancer after failure of first-line chemotherapy: A report of two cases and literature review J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-28 Mingli Yuan, Liangchao Wang, Yang Xiao, Xiaoqun Guo, Yi Hu
Although immunotherapy regimens for advanced non-small-cell lung cancer (NSCLC) improve survival in selected sub-populations, their efficacy remains far from ideal due to underlying resistance; therefore, multimodal combination strategies are needed to optimize their efficacy. In our report, two patients with advanced NSCLC with negative targetable mutations, who had failed first-line chemotherapy
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Using a deep learning approach for implanted seed detection on fluoroscopy images in prostate brachytherapy J. Contemp. Brachyther. (IF 1.4) Pub Date : 2023-02-27 Andy Yuan, Tarun Podder, Jiankui Yuan, Yiran Zheng
Purpose: To apply a deep learning approach to automatically detect implanted seeds on a fluoroscopy image in prostate brachytherapy. Material and methods: Forty-eight fluoroscopy images of patients, who underwent permanent seed implant (PSI) were used for this study after our Institutional Review Boards approval. Pre-processing procedures that were used to prepare for the training data, included encapsulating