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A Novel Approach for Conducting a Catchment Area Analysis of Breast Cancer by Age and Stage for a Community Cancer Center Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-03-07 Scott D. Siegel, Yuchen Zhang, Shannon M. Lynch, Jennifer Rowland, Frank C. Curriero
Background: The U.S. Preventive Services Task Force recently issued an updated draft recommendation statement to initiate breast cancer (BC) screening at age 40, reflecting well-documented disparities in BC mortality that disproportionately impact younger Black women. This study applied a novel approach to identify hotspots of BC diagnosed before age 50 and/or at an advanced stage to improve BC detection
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Diabetes risk reduction diet and colorectal cancer risk Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-03-07 Arianna Natale, Federica Turati, Martina Taborelli, Attilio Giacosa, Livia S. A. Augustin, Anna Crispo, Eva Negri, Marta Rossi, Carlo La Vecchia
Background Diabetes has been associated with colorectal cancer (CRC). We aimed at evaluating whether adherence to a diabetes risk reduction diet (DRRD) could favorably influence the risk of CRC. Methods Data came from a multicentric Italian case-control study including 1,953 histologically confirmed CRC cases and 4,154 hospital controls admitted for acute non-neoplastic diseases. Diet was assessed
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Joint Associations of Diet and Device-measured Physical Activity with Mortality and Incident CVD and Cancer: a prospective analysis of the UK Biobank Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-03-04 Elif Inan Eroglu, Matthew Ahmadi, Raaj Kishore. Biswas, Ding Ding, Leandro F M. Rezende, I-Min Lee, Edward L. Giovannucci, Emmanuel Stamatakis
Background: We examined the joint associations of diet and device-measured intensity-specific PA with all-cause mortality (ACM), cardiovascular disease (CVD) and cancer incidence. Methods: We used data from 79,988 participants from the UK Biobank, a population-based prospective cohort study. Light PA (LPA), moderate-to-vigorous PA (MVPA), vigorous PA (VPA) and total PA (TPA) were measured using a wrist-worn
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Diffsig: Associating Risk Factors With Mutational Signatures Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-03-01 Ji-Eun Park, Markia A. Smith, Sarah C. Van Alsten, Andrea Walens, Di Wu, Katherine A. Hoadley, Melissa A. Troester, Michael I. Love
Background: Somatic mutational signatures elucidate molecular vulnerabilities to therapy and therefore detecting signatures and classifying tumors with respect to signatures has clinical value. However, identifying the etiology of the mutational signatures remains a statistical challenge, with both small sample sizes and high variability in classification algorithms posing barriers. As a result, few
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Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women. Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-27 Samyukta Sah, Olatomiwa O. Bifarin, Samuel G. Moore, David A. Gaul, Hyewon Chung, Sun Young Kwon, Hanbyoul Cho, Chi-Heum Cho, Jae-Hoon Kim, Jaeyeon Kim, Facundo M. Fernández
Background: Distinguishing ovarian cancer (OC) from other gynecological malignancies is crucial for patient survival yet hindered by non-specific symptoms and limited understanding of OC pathogenesis. Accumulating evidence suggests a link between OC and deregulated lipid metabolism. Most studies have small sample sizes, especially for early-stage cases, and lack racial/ethnic diversity, necessitating
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Severity of Complications and Duration of Type 2 Diabetes and the Risk of Cancer: A Population-based Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-27 Yu-Wen Hu, Chiu-Mei Yeh, Chia-Jen Liu, Tzeng-Ji Chen, Nicole Huang, Yiing-Jenq Chou
Background: The literature on the association between diabetes severity and cancer risk is limited and inconclusive. The study aimed to evaluate the association between the adapted Diabetes Complications Severity Index (aDCSI) and the duration of type 2 diabetes and cancer risk. Methods: Patients aged 20 years or older with newly diagnosed type 2 diabetes between January 1, 2007 and December 31, 2011
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Breast cancer stage and size detected with film versus digital mammography in New South Wales, Australia: a population-based study using routinely collected data Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-26 Rachel Farber, Nehmat Houssami, Kevin McGeechan, Alexandra Barratt, Katy JL. Bell
Background Digital mammography has replaced film mammography in breast screening programs globally, including Australia. This led to an increase in the rate of detection, but whether there was increased detection of clinically important cancers is uncertain. Methods In this population-wide retrospective cohort study in New South Wales, Australia spanning 2004-2016 and including 4,631,656 screens, there
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Large-Scale Cancer Genomic Analysis Reveals Significant Disparities Between Microsatellite Instability and Tumor Mutational Burden Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-23 Jungyoon Choi, Kyong Hwa Park, Yeul Hong Kim, Jason K. Sa, Hwa Jung Sung, Yu-Wei Chen, Zhishan Chen, Chao Li, Wanqing Wen, Qingrun Zhang, Xiao-Ou Shu, Wei Zheng, Jung Sun Kim, Xingyi Guo
Background: Microsatellite instability (MSI) and tumor mutational burden (TMB) are predictive biomarkers for pan-cancer immunotherapy. The interrelationship between MSI-high (MSI-H) and TMB-high (TMB-H) in human cancers and their predictive value for immunotherapy in lung cancer remain unclear. Methods: We analyzed somatic mutation data from the Genomics Evidence Neoplasia Information Exchange (n =
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Inequities in the Impacts of Hurricanes and other Extreme Weather Events for Cancer Survivors Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-22 Lisa M. Gudenkauf, Cassandra A. Hathaway, Judith E. Carroll, Brent J. Small, Xiaoyin Li, Aasha I. Hoogland, Eida Castro, Guillermo N. Armaiz-Pena, Laura B. Oswald, Heather SL. Jim, Shelley S. Tworoger, Brian D. Gonzalez
In this mini review, we examine the impacts of hurricanes and other extreme weather events on cancer survivors, focusing on structural and social determinants of health. We briefly explore influences on biological, psychosocial, and behavioral outcomes and discuss risk and resilience factors in cancer survivorship during and after hurricanes. Our goal is to inform future directions for research that
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Sleep and risk of pancreatic cancer in the UK Biobank Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-22 Joshua R. Freeman, Pedro F. Saint-Maurice, Ting Zhang, Charles E. Matthews, Rachael Z. Stolzenberg-Solomon
Background: Light at night, which may cause circadian disruption, is a potential pancreatic cancer risk factor. However, evidence from related exposures such as poor sleep health and shift work remains inconclusive and sparsely investigated. Methods: We evaluated associations between self-reported typical sleep duration, chronotype, shift work, insomnia symptoms, snoring, and daytime sleeping and pancreatic
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Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-19 Arthur Bookstein, Justine Po, Chiuchen Tseng, Timothy V. Larson, Juan Yang, Sung-shim L. Park, Jun Wu, Salma Shariff-Marco, Pushkar P. Inamdar, Ugonna Ihenacho, Veronica Wendy. Setiawan, Mindy C. DeRouen, Loïc Le Marchand, Daniel O. Stram, Jonathan Samet, Beate Ritz, Scott Fruin, Anna H. Wu, Iona Cheng
Background: Ultrafine particles (UFPs) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. Methods: Within
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Prognostic Value of Pre-treatment Plasma C-Reactive Protein in Patients with Early-Stage Breast Cancer Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-15 Høgni H. Andersen, Stig E. Bojesen, Julia S. Johansen, Bent Ejlertsen, Tobias Berg, Malgorzata Tuxen, Kasper Madsen, Hella Danø, Henrik Flyger, Maj-Britt Jensen, Dorte L. Nielsen
Background: Breast cancer incidence is now the highest among all cancers and accountable for 6.6% of all cancer-related deaths worldwide. Studies of the prognostic utility of plasma CRP measurement in early-stage breast cancer have given discrepant results. Methods: We identified 6942 patients in the Danish Breast Cancer Cooperative Group database with early-stage breast cancer diagnosed between 2002
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Differences in Smoking Behavior by Nativity, Race/Ethnicity, and Education Among Women Diagnosed with Breast Cancer Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-12 Stephen P. Uong, Jacqueline M. Torres, Stacey E. Alexeeff, Brittany N. Morey, Bette J. Caan, Lawrence H. Kushi, Candyce H. Kroenke
Background: We evaluated smoking differences across nativity and race/ethnicity among women diagnosed with breast cancer. Methods: In our Northern Californian pooled population of 5,653 [670 Asian, 690 Hispanic, and 4,300 Non-Hispanic White (White)] women diagnosed with breast cancer, we evaluated smoking differences across nativity, race/ethnicity, and acculturation and effect modification of nativity
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Patterns of cancer-related healthcare access across Pennsylvania: Analysis of novel census tract-level indicators of persistent poverty Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-08 Jennifer L. Moss, Nathaniel R. Geyer, Eugene J. Lengerich
Background. Persistent poverty census tracts have had ≥20% of the population living below the federal poverty line for 30+ years. We assessed the relationship between persistent poverty and cancer-related healthcare access across census tracts in Pennsylvania. Methods. We gathered publicly-available census tract-level data on persistent poverty, rurality, and sociodemographic variables, as well as
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Trends of Prostate Cancer Morbidity in Low-Incidence Countries from 1990–2019 Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-06 Jinjiang Jiang, Bo Chen, Bo Tang, Jie Yang, Ting Zhang, Jinze Li, Daqing Tan, Qiang Wei
Background: Our study was designed to elucidate the morbidity trends of prostate cancer in low-incidence countries. Methods: Data on prostate cancer were extracted from the 2019 Global Burden of Disease study. A cluster analysis of growth rates stratified by age was conducted, and correlation analyses were performed between age-standardized incidence rates (ASIR), estimated annual percent change (EAPC)
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Choosing Wisely: Applying Value-Based Economic Principles to Population Science Research Investment Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-06 Kevin D. Frick, Kathy J. Helzlsouer
Scientific research requires a substantial investment of time, effort, and money by researchers and funders. The funding that would be needed for all meritorious proposals far exceeds available resources. Major funding organizations use a multistep process for allocating research dollars that follows and extends beyond scientific peer review with considerations including mission priority, budget, and
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Fecal Immunochemical Test Screening: Maximizing Success by Minimizing Failure Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-06 Joseph C. Anderson, Douglas J. Robertson
Implementing fecal immunochemical testing (FIT) through clinic based opportunistic screening or programmatic mailing is not as straightforward as it seems. Liu and colleagues present data for 56,980 individuals who submitted a FIT in a safety net hospital system. In 10.2% (N = 5,819), the test was deemed unsatisfactory. These data demonstrate that there is significant room for improvement in clinical
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The Reach of Calls and Text Messages for Mailed FIT Outreach in the PROMPT Stepped-wedge Colorectal Cancer Screening Trial Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-06 Gloria D. Coronado, Denis B. Nyongesa, Amanda F. Petrik, Jamie H. Thompson, Anne L. Escaron, Tuan Pham, Michael C. Leo
Background Mailed fecal immunochemical test (FIT) outreach can improve colorectal cancer screening participation. We assessed the reach and effectiveness of adding notifications to mailed FIT programs. Methods We conducted secondary analyses of a stepped-wedge evaluation of an enhanced mailed FIT program (n = 15 clinics). Patients were stratified by prior FIT completion. Those with prior FIT were sent
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Addressing Social Risks to Accelerate Health Equity in Cancer Prevention and Control Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-06 Jean A. McDougall, Theresa A. Hastert, Dede K. Teteh, Charles R. Rogers, Jennifer L. Moss, Carol Y. Ochoa-Dominguez, Perla Chebli, Arnethea L. Sutton, Bo Qin, Erica T. Warner, Serena Xiong
Addressing social risks in cancer prevention and control presents a new opportunity for accelerating cancer health equity. As members of the American Society of Preventive Oncology (ASPO) Cancer Health Disparities Special Interest Group, we describe the current state of science on social risks in oncology research and practice. To reduce and eliminate the unjust burden of cancer, we also provide recommendations
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Risk factors for ovarian cancer by BRCA status: a collaborative case-only analysis Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-02-01 Kate Gersekowski, Renhua Na, Kathryn Alsop, Rachel Delahunty, Ellen L. Goode, Julie M. Cunningham, Stacey J. Winham, Paul D P. Pharoah, Honglin Song, Penelope M. Webb
Background Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of associations with established reproductive, hormonal and lifestyle risk factors between BRCA mutation carriers and non-carriers. Methods We pooled data from five
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The impact of inherited genetic variation on DNA methylation in prostate cancer and benign tissues of African American and European American men Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-31 Dayana Delgado, Marc Gillard, Lin Tong, Kathryn Demanelis, Meritxell Oliva, Kevin J. Gleason, Meytal Chernoff, Lin Chen, Gladell P. Paner, Donald Vander Griend, Brandon L. Pierce
Background: American men of African ancestry (AA) have higher prostate cancer (PCa) incidence and mortality rates compared to American men of European ancestry (EA). Differences in genetic susceptibility mechanisms may contribute to this disparity. Methods: To gain insights into the regulatory mechanisms of PCa susceptibility variants, we tested the association between SNPs and DNA methylation (DNAm)
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Oncogenic Oral Human Papillomavirus Clearance Patterns Over 10 years Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-31 Gypsyamber D'Souza, Sakshi R. Tewari, Tanya Troy, Jennifer Webster-Cyriaque, Dorothy J. Wiley, Cecile Delille. Lahiri, Frank Joseph. Palella, Maura L. Gillison, Howard D. Strickler, Linda Struijk, Tim Waterboer, Ken Ho, Jennafer Kwait, Jason Lazar, Kathleen M. Weber, Carole Fakhry
Background: Effective screening for Oropharyngeal cancer (OPC) is lacking. Four oncogenic HPV clearance definitions were explored to understand long-term natural history for persistent oncogenic oral HPV (oncHPV), the precursor of OPC. Methods: Prospective multicenter cohort of participants living with/at-risk for HIV, with oral rinse and gargle samples collected every 6-12 months for up to 10 years
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Prevalence and correlates of post-diagnosis alcohol use among cancer survivors Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-31 Jaimee L. Heffner, Mimi Ton, Salene M W. Jones, Rachel C. Malen, Stacey A. Cohen, Polly A. Newcomb
Background: Alcohol is a risk factor for cancer and may pose unique risks for cancer survivors. Population-based studies of confirmed cancer cases are needed to estimate the extent of drinking among cancer survivors and to understand which survivors are most at-risk of alcohol-related health problems. Methods: Cancer survivors who resided in the Puget Sound Surveillance, Epidemiology, and End Results
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Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-29 Hyung-Suk Yoon, Jie Wu, Chris Shidal, Yan Sun, Adrian A. Franke, Jae Jeong Yang, Dejana Braithwaite, Regina Courtney, Hui Cai, William J. Blot, Xiao-Ou Shu, Wei Zheng, Qiuyin Cai
Background: Despite the various anticancer activities of tocopherols, little is known about tocopherols associated with lung cancer risk among low-income African Americans (AAs) and European Americans (EAs) who are disproportionately affected by the disease. Methods: We conducted a nested case-control study that included 209 incident lung cancer cases and 406 matched controls within the Southern Community
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Do Contemporary Cancer Survivors Experience Better Quality of Life? Evaluating a Decade of SEER Medicare Health Outcomes Survey Data Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-29 Benjamin T. Allaire, Marc L. Horvath, Lisa M. Lines, Amy J. Davidoff, Ashley W. Smith, Roxanne E. Jensen
Background: A cancer diagnosis may have deleterious effects on health-related quality of life (HRQOL) as adults age. This study examined differences in HRQOL between cancer and matched non-cancer Medicare beneficiaries over 65, within and across two time periods. Methods: We used novel matching methods on data from the Surveillance, Epidemiology and End Results (SEER)-Medicare Health Outcomes Survey
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Risk of clinically significant prostate cancer after a non-suspicious prostate MRI - a comparison with the general population Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-25 Juho Pylväläinen, Jaakko Hoffström, Anu Kenttämies, Anssi Auvinen, Tuomas Mirtti, Antti Rannikko
Background: We compare the risk of clinically significant (csPCa; ISUP Grade Group ≥ 2) and insignificant prostate cancer (isPCa; ISUP Grade Group 1) in men with a non-suspicious prostate MRI (nMRI; PI-RADS ≤ 2) with the general population, and assess the value of PSA density (PSAD) in stratification. Methods: In this retrospective population-based cohort study we identified 1,682 50–79-year-old men
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The associations between intakes of one-carbon metabolism-related vitamins and breast density among young women Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-25 Eunyoung Han, Linda Van Horn, Linda Snetselaar, John A. Shepherd, Yoon Jung Park, Hyesook Kim, Seungyoun Jung, Joanne F. Dorgan
Background: Folate is the primary methyl donor and B vitamins are cofactors for one-carbon metabolism that maintain DNA integrity and epigenetic signatures implicated in carcinogenesis. Breast tissue is particularly susceptible to stimuli in early life. Only limited data are available on associations of one-carbon metabolism-related vitamin intake during youth and young adulthood with breast density
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Eyes wide open: Sleep as a potential contributor to racial and ethnic disparities in cancer Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-25 Lauren E. Barber, Lauren E. McCullough, Dayna A. Johnson
US racial and ethnic minoritized groups face disproportionate cancer burdens compared to White Americans. Investigating modifiable factors, such as sleep, that are socially patterned and inequitably distributed by race and ethnicity may advance understanding of cancer disparities and provide intervention opportunities. Emerging data suggest poor sleep health is associated with cancer. Yet, its contribution
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Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-25 Sarah C. Van Alsten, Matthew R. Dunn, Alina M. Hamilton, Joannie M. Ivory, Xiaohua Gao, Erin L. Kirk, Joseph S. Nsonwu-Farley, Lisa A. Carey, Yara Abdou, Katherine E. Reeder-Hayes, Mya L. Roberson, Stephanie B. Wheeler, Marc A. Emerson, Terry Hyslop, Melissa A. Troester
Background: OncotypeDx is a prognostic and predictive genomic assay used in early-stage hormone receptor positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. It is used to inform adjuvant chemotherapy decisions, but not all eligible women receive testing. We aimed to assess variation in testing by demographics and geography, and to determine whether testing was associated
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Association of fibroids, endometriosis, and gynecologic surgeries with breast cancer incidence and hormone receptor subtypes Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-23 Jordan Zeldin, Dale P. Sandler, Kemi Ogunsina, Katie M. O'Brien
Background Fibroids and endometriosis are sex hormone-mediated and exhibit cancer-like behavior. Breast cancer may be more common in women who have had these conditions, but the literature is conflicting and does not always address factors like hysterectomy/oophorectomy status, race/ethnicity, menopause, and hormone receptor subtypes. Methods Data are from the Sister Study, a cohort of 50,884 U.S.
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Trends and Disparities in Curative-Intent Treatment for Early-Stage Non-Small Cell Lung Cancer: A Population-Based Analysis of Surgery and SBRT Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-22 Qinran Liu, Heidy N. Medina, Estelamari Rodriguez, Kamaria T. Jacobs, Clyde Brown, Tulay Koru-Sengul, Gilberto Lopes, Paulo S. Pinheiro
Background: Despite the increasing adoption of stereotactic body radiotherapy (SBRT) as a recommended alternative for early-stage non-small cell lung cancer (NSCLC), population-based research on racial/ethnic disparities in curative-intent treatment accounting for SBRT remains limited. This study investigated trends and disparities in receiving curative-intent surgery and/or SBRT in a diverse, retrospective
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Racial and Ethnic Disparities in Hepatocellular Carcinoma Treatment Receipt in the United States: A Systematic Review and Meta-Analysis Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-22 Nikita Sandeep Wagle, Sulki Park, David Washburn, Robert Ohsfeldt, Hye-Chung Kum, Amit G. Singal
Background: Racial and ethnic disparities in hepatocellular carcinoma (HCC) prognosis exist, partly related to differential failures along the cancer care continuum. We characterized racial and ethnic disparities in treatment receipt among patients with HCC in the United States. Methods: We searched Medline, Embase, and CINAHL databases to identify studies published between January 2012 and March 2022
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Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-22 Claire E. Thomas, Peter Georgeson, Conghui Qu, Robert S. Steinfelder, Daniel D. Buchanan, Mingyang Song, Tabitha A. Harrison, Caroline Y. Um, Meredith A. Hullar, Mark A. Jenkins, Bethany Van Guelpen, Brigid M. Lynch, Yohannes Adama Melaku, Jeroen R. Huyghe, Elom K. Aglago, Sonja I. Berndt, Lisa A. Boardman, Peter T. Campbell, Yin Cao, Andrew T. Chan, David A. Drew, Jane C. Figueiredo, Amy J. French
Background: The genotoxin colibactin causes a tumor single base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors association with colorectal cancer (CRC) risk and survival differ by SBS88. Methods: Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite
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Risk of Gastric Adenocarcinoma in a Multiethnic Population undergoing Routine Care: an Electronic Health Records Cohort Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-17 Robert J. Huang, Edward S. Huang, Satish Mudiganti, Tony Chen, Meghan C. Martinez, Sanjay Ramrakhiani, Summer S. Han, Joo Ha. Hwang, Latha P. Palaniappan, Su-Ying Liang
Background: Gastric adenocarcinoma (GAC) is often diagnosed at advanced stages and portends a poor prognosis. We hypothesized that electronic health records (EHR) could be leveraged to identify individuals at highest risk for GAC from the population seeking routine care. Methods: This was a retrospective cohort study, with endpoint of GAC incidence as ascertained through linkage to an institutional
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Rural-urban differences in sun exposure and protection behaviors in the United States Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-16 Allison C. Dona, Patricia I. Jewett, Carrie Henning-Smith, Rehana L. Ahmed, Maria L. Wei, DeAnn Lazovich, Rachel I. Vogel
Background: Evidence regarding whether rural residence is a risk factor for skin cancer is mixed. We compared sun exposure and protection behaviors between rural and urban residents by ethno-racial group in the United States. Methods: We analyzed data from three (2013-2018) National Health and Nutrition Examination Survey (NHANES) cycles. We compared self-reported sun exposure and protection measures
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INTERACTION BETWEEN CONTINUOUS PACK-YEARS SMOKED AND POLYGENIC RISK SCORE ON LUNG CANCER RISK: PROSPECTIVE RESULTS FROM THE FRAMINGHAM HEART STUDY Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-16 Meredith S. Duncan, Hector Diaz-Zabala, James Jaworski, Hilary A. Tindle, Robert A. Greevy, Loren Lipworth, Rayjean J. Hung, Matthew S. Freiberg, Melinda C. Aldrich
Background: Lung cancer risk attributable to smoking is dose-dependent, yet few studies examining a polygenic risk score (PRS) by smoking interaction have included comprehensive lifetime pack-years smoked. Methods: We analyzed data from participants of European ancestry in the Framingham Heart Study Original (n=454) and Offspring (n=2,470) cohorts enrolled in 1954 and 1971, respectively, and followed
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Mitochondrial DNA Haplogroups and Single Nucleotide Polymorphisms:Risk Factors in Multiple Cancers Based on a Cross-tumor Analysis in Chinese Population Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-12 Dongbo Chen, Zeyu Yan, Qing Yuan, Fanfan Xie, Yang Liu, Zehui Feng, Zhenni Wang, Feng Zhou, Jinliang Xing, Zhaohui Zhang, Fuli Wang, Xu Guo
Background: Mitochondrial DNA’s haplogroups and single nucleotide polymorphisms were associated with the risk of different cancer. However, there is no evidence that the same haplogroup or mtSNP exhibits the pleiotropic effect on multiple cancers. Methods: We recruited 2489 participants, including patients with colorectal, hepatocellular, lung, ovarian, bladder, breast, pancreatic, and renal cell carcinoma
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Isolating the Drivers of Racial Inequities in Prostate Cancer Treatment Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-12 Noah Hammarlund, Sarah K. Holt, Anirban Basu, Ruth Etzioni, Danté Morehead, Jenney R. Lee, Erika M. Wolff, John L. Gore, Yaw A. Nyame
Background: Black individuals in the US are less likely than White individuals to receive curative therapies despite a two-fold higher risk of prostate cancer death. While research has described treatment inequities, few studies have investigated underlying causes. Methods: We analyzed a cohort of 40,137 Medicare beneficiaries (66 and older) linked to the SEER cancer registry who had clinically significant
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Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-08 Naiyu Chen, Colleen B. McGrath, Caroline I. Ericsson, Jane B. Vaselkiv, Emily M. Rencsok, Konrad H. Stopsack, Hannah E. Guard, Karen A. Autio, Dana E. Rathkopf, Deborah Enting, Rhonda L. Bitting, Joaquin Mateo, Charles Waihenya. Githiaka, Kim N. Chi, Heather H. Cheng, Ian D. Davis, Simon G. Anderson, Simone Ann Marie. Badal, Anders Bjartell, Kjell M. Russnes, Elisabeth I. Heath, Mark M. Pomerantz,
Background: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International
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Hematocrit is associated with cancer-related fatigue in colorectal cancer survivors: a longitudinal analysis Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-05 Joann Kiebach, Judith de Vries-ten Have, Fränzel JB. van Duijnhoven, Dieuwertje E. Kok, Anne-Sophie van Lanen, Ewout A. Kouwenhoven, Johannes HW de Wilt, Ruud W M. Schrauwen, Ellen Kampman, Renate M. Winkels, Evertine Wesselink
Background: Cancer-related fatigue (CRF) is a frequent symptom in colorectal cancer survivors. It is unknown to what extent anemia may contribute to CRF in colorectal cancer survivors. This study aimed to investigate the association between hematocrit, as marker for anemia, and CRF among colorectal cancer survivors from diagnosis until two years thereafter. Methods: The study population included 1
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Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-05 Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Abbas Rezaianzadeh, Alireza Ansari-Moghaddam, Mahdieh Bakhshi, Azim Nejatizadeh, Monireh Sadat Seyyedsalehi, Ahmad Naghibzadeh-Tahami, AliAkbar Haghdoost, Elham Mohebbi, Neal D. Freedman, Reza Malekzadeh, Arash Etemadi, Farin Kamangar, Elisabete Weiderpass, Eero Pukkala, Paolo Boffetta, Kazem Zendehdel
Background: Limited data exist for the association between bladder cancers and waterpipe smoking, an emerging global public health concern. Methods: We used the IROPICAN database in Iran and employed multivariable logistic regression, adjusting for cigarette smoking, opium use, and other confounding factors. In addition, we studied the association between exclusive waterpipe smoking and bladder cancer
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Lung cancer in ever- and never-smokers: findings from multi-population GWAS studies Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2024-01-05 Yafang Li, Xiangjun Xiao, JianRong Li, Younghun Han, Chao Cheng, Gail F. Fernandes, Shannon E. Slewitzke, Susan M. Rosenberg, Meng Zhu, Jinyoung Byun, Yohan Bossé, James D. McKay, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C. Christiani, Gad Rennert, Susanne M. Arnold, Gary
Background: Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer. Methods: We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis
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Physical Activity and Mammographic Density in Japanese Women Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-26 Mihye Lee, Rina Kotake, Hideko Yamauchi
Background: Dense breast is one of the strong risk factors for breast cancer among women. While it has been established that physical activity is associated with decreased risk for breast cancer, results have been inconsistent in terms of mammographic density. Thus, we examined physical activity in relation to mammographic density among Japanese women in Tokyo. Methods: We used 123,026 records from
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SARS-CoV-2 Infection and Related Hospitalization Among Cancer Survivors Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-21 Larissa L. White, Andrea N. Burnett-Hartman, Laura E. Ichikawa, Shauna R. Goldberg, Jessica Chubak, Heather Spencer Feigelson, Aruna Kamineni
Background: Little is known about SARS-CoV-2 infection and COVID-19 severity among a growing population of cancer survivors. We describe the association of infection and related hospitalization by recency of cancer diagnosis in a large US cohort. Methods: Participants were sent electronic surveys between April 2020 and January 2021 to collect information on SARS-CoV-2 infection and potential COVID-19-related
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The Salivary Microbiome and Predicted Metabolite Production are Associated with Barrett’s Esophagus and High Grade Dysplasia or Adenocarcinoma Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-20 Quinn S. Solfisburg, Federico Baldini, Brittany Baldwin-Hunter, George I. Austin, Harry H. Lee, Heekuk Park, Daniel E. Freedberg, Charles J. Lightdale, Tal Korem, Julian A. Abrams
Background: Esophageal adenocarcinoma (EAC) is rising in incidence, and established risk factors do not explain this trend. Esophageal microbiome alterations have been associated with Barrett’s esophagus (BE) and dysplasia and EAC. The oral microbiome is tightly linked to the esophageal microbiome; this study aimed to identify salivary microbiome-related factors associated with BE, dysplasia, and EAC
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Maternal prenatal use of alcohol, tobacco, and illicit drugs and associations with childhood cancer subtypes Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-19 Courtney Elise. Wimberly, Natalie B. Gulrajani, Jeffrey B. Russ, Daniel Landi, Joseph L. Wiemels, Lisa Towry, John K. Wiencke, Kyle M. Walsh
Background: The association between childhood cancer risk and maternal prenatal substance use/abuse remains uncertain due to modest sample sizes and heterogeneous study designs. Methods: We surveyed parents of children with cancer regarding maternal gestational use of tobacco, alcohol, and illicit drugs, using a Likert-type scale, and demographic, perinatal, and clinical variables. Multivariable log-Poisson
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Genome-wide gene-environment interaction analyses to understand the relationship between red meat and processed meat intake and colorectal cancer risk. Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-19 Mariana C. Stern, Joel Sanchez Mendez, Andre E. Kim, Mireia Obón-Santacana, Ferran Moratalla-Navarro, Vicente Martín, Victor Moreno, Yi Lin, Stephanie A. Bien, Conghui Qu, Yu-Ru Su, Emily White, Tabitha A. Harrison, Jeroen R. Huyghe, Catherine M. Tangen, Polly A. Newcomb, Amanda I. Phipps, Claire E. Thomas, Eric S. Kawaguchi, Juan Pablo Lewinger, John L. Morrison, David V. Conti, Jun Wang, Duncan C
Background: High red meat and/or processed meat consumption are established colorectal cancer (CRC) risk factors. We conducted a genome-wide gene-environment (GxE) interaction analysis to identify genetic variants that may modify these associations. Methods: A pooled sample of 29,842 CRC cases and 39,635 controls of European ancestry from 27 studies were included. Quantiles for red meat and processed
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Differences in Survival between Black and White Patients with Head and Neck Squamous Cell Carcinoma: Comparison of Data from the DoD Central Cancer Registry and SEER Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-15 Jie Lin, Michael I. Orestes, Craig D. Shriver, Kangmin Zhu
Background: Barriers to health care access may contribute to the poorer survival of Black patients with head and neck squamous cell carcinoma (HNSCC) than their White counterparts in the U.S. general population. The Department of Defense’s (DoD) Military Health System (MHS) provides universal health care access to all beneficiaries with various racial backgrounds. Methods: We compared overall survival
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Patterns of Anticoagulation Use and All-Cause of Mortality in Cancer Patients with Atrial Fibrillation Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-13 Xu Han, Xiaolei Yang, Tesfaldet H. Hidru, Chengfang Wang, Yunlong Xia
Background: There is uncertainty regarding the clinical benefit of anticoagulant (AC) treatment in patients with cancer with atrial fibrillation (AF). We aimed to evaluate the distribution and patterns of AC use and its impact on all-cause mortality in cancer patients with AF. Methods: A total of 1,653 patients with cancer diagnosed with AF were included in this retrospective cohort analysis. Multivariable
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Evaluation of algorithms using automated health plan data to identify breast cancer recurrences Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-13 Erin J. Aiello Bowles, Candyce H. Kroenke, Jessica Chubak, Jenna Bhimani, Kelli O'Connell, Susan Brandzel, Emily Valice, Rachael Doud, Mary Kay. Theis, Janise M. Roh, Narre Heon, Sonia Persaud, Jennifer J. Griggs, Elisa V. Bandera, Lawrence H. Kushi, Elizabeth D. Kantor
Background: We updated algorithms to identify breast cancer recurrences from administrative data, extending previously developed methods. Methods: In this validation study, we evaluated pairs of breast cancer recurrence algorithms (vs. individual algorithms) to identify recurrences. We generated algorithm combinations that categorized discordant algorithm results as no recurrence (High Specificity
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Sugar-sweetened beverage consumption and breast cancer in pre- and post-menopausal women Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-12 Adriana Garduño-Alanis, Angélica Ángeles-Llerenas, Luisa Maria Sánchez-Zamorano, Lourdes Flores-Luna, Mario Flores-Aldana, Gabriela Torres-Mejía
Background: The consumption of sugar-sweetened beverages (SSBs), of which Mexico is a large consumer, has been associated with the risk of breast cancer. We assessed the association between SSBs consumption and breast cancer risk in pre- and postmenopausal women. Methods: We performed a multicenter population-based case-control study in Mexico City, Monterrey, and Veracruz. We recruited 1,000 cases
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Genetic and environmental causes of variation in an automated breast cancer risk factor based on mammographic textures Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-07 Zhoufeng Ye, Gillian S. Dite, Tuong L. Nguyen, Robert J. Maclnnis, Daniel F. Schmidt, Enes Makalic, Osamah M. Al-Qershi, Tu Nguyen-Dumont, Benjamin Goudey, Jennifer Stone, James G. Dowty, Graham G. Giles, Melissa C. Southey, John L. Hopper, Shuai Li
Background: Cirrus is an automated risk predictor for breast cancer that comprises texture-based mammographic features and is mostly independent of mammographic density. We investigated genetic and environmental variance of variation in Cirrus. Methods: We measured Cirrus for 3195 breast-cancer-free participants, including 527 pairs of monozygotic (MZ) twins, 271 pairs of dizygotic (DZ) twins, and
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Community-level factors associated with hepatocellular carcinoma incidence and mortality: an observational registry study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-07 Catherine Mezzacappa, Raiza Rossi, Ariel Jaffe, Tamar H. Taddei, Mario Strazzabosco
Background: Hepatocellular carcinoma (HCC) incidence and outcomes vary across populations in the United States, but few studies evaluate local drivers of observed disparities. We measured HCC incidence at the community level and assessed community-level HCC risk factors with the goal of informing resource allocation to improve early case detection, which is associated with improved outcomes. Methods:
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The influence of smoking and occupational risk factors on DNA methylation in the AHRR and F2RL3 genes Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-05 Laura Pelland-St-Pierre, Michael C. Pham, Alice Quynh Huong. Nguyen, Romain Pasquet, Sherryl A. Taylor, Delphine Bosson-Rieutort, Anita Koushik, Vikki Ho
Background: AHRR and F2RL3 hypomethylation has been associated with lung cancer. In this study, we investigated the cross-sectional association between smoking and occupational exposures, and AHRR and F2RL3 methylation. Methods: A case-control study was nested in CARTaGENE to examine the association between AHRR and F2RL3 methylation and lung cancer risk (200 cases; 400 controls). A secondary analysis
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Genetic factors and long-term treatment-related neurocognitive deficits, anxiety, and depression in childhood leukemia survivors: an exome-wide association study. Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-12-05 Kateryna Petrykey, Sarah Lippé, Serge Sultan, Philippe Robaey, Simon Drouin, Laurence Affret-Bertout, Patrick Beaulieu, Pascal St-Onge, Jessica L. Baedke, Yutaka Yasui, Melissa M. Hudson, Caroline Laverdière, Daniel Sinnett, Maja Krajinovic
Background: An increased risk of neurocognitive deficits, anxiety, and depression has been reported in childhood cancer survivors. Methods: We analyzed associations of neurocognitive deficits, as well as anxiety and depression, with common and rare genetic variants derived from whole-exome sequencing data of acute lymphoblastic leukemia (ALL) survivors from the PETALE cohort. In addition, significant
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The association between state-level structural racism and alcohol and tobacco use behaviors among a national probability sample of Black Americans Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-11-30 Nathaniel Woodard, James Butler, Debarchana Ghosh, Kerry M. Green, Cheryl L. Knott
Background: Structural racism is how society maintains and promotes racial hierarchy and discrimination through established and interconnected systems. Structural racism is theorized to promote alcohol and tobacco use, which are risk factors for adverse health and cancer-health outcomes. The current study assesses the association between measures of state-level structural racism and alcohol and tobacco
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Potential for cure by stage across the cancer spectrum in the United States Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-11-29 Earl Hubbell, Christina A. Clarke, Karin E. Smedby, Hans-Olov Adami, Ellen T. Chang
Background: Cure fraction—the proportion of persons considered cured of cancer after long- term follow-up—reflects the total impact of cancer control strategies, including screening, without lead-time bias. Previous studies have not reported stage-stratified cure fraction across the spectrum of cancer types. Methods: Using a mixture cure model, we estimated cure fraction across stages for 21 cancer
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Alcohol, smoking, and risks of breast cancer recurrence and mortality among women with luminal, triple-negative, and HER2-overexpressing breast cancer Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-11-29 Nicole C. Loroña, Megan Othus, Kathleen E. Malone, Hannah M. Linden, Mei-Tzu C. Tang, Christopher I. Li
Background: This study evaluates the relationship between smoking, alcohol, and breast cancer outcomes according to molecular subtype. Methods: This population-based prospective cohort consisted of 3,876 women aged 20-69 diagnosed with a first primary invasive breast cancer from 2004 through 2015 in the Seattle–Puget Sound region. Breast cancer was categorized into three subtypes based on estrogen
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Evaluating the Impact of Race and Ethnicity on Health-Related Quality of Life Disparities in Patients with Esophageal Cancer: A SEER-MHOS National Database Study Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-11-28 Trudy C. Wu, Matthew J. Farrell, Nicki Karimi-Mostowfi, Basil Chaballout, Wisdom O. Akingbemi, Tristan R. Grogan, Ann Raldow
Background: It is unclear whether health-related quality of life (HRQOL) disparities exist between racial/ethnic groups in older patients with esophageal cancer, pre- and post-diagnosis. Methods: Using the SEER-MHOS national database, we included patients 65 years old or greater with esophageal cancer diagnosed from 1996-2017. HRQOL data within 36 months before and after diagnosis were measured by
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Decline in the incidence of distant recurrence of breast cancer: A population-based health record linkage study, Australia 2001-2016. Cancer Epidemiol. Biomarkers Prev. (IF 3.8) Pub Date : 2023-11-28 Sarah J. Lord, Benjamin Daniels, Dianne L. O'Connell, Belinda E. Kiely, Jane Beith, Andrea L. Smith, Sallie-Anne Pearson, Kim-Lin Chiew, Max K. Bulsara, Nehmat Houssami
Background: We investigated differences in cumulative incidence of first distant recurrence following non-metastatic breast cancer over a time period when new adjuvant therapies became available in Australia. Methods: We conducted a health record linkage study of females with localized (T1-3N0) or regional (T4 or N+) breast cancer in the New South Wales Cancer Registry in 2001-2002 and 2006-2007. We