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Selective Capsulotomies and Partial Capsulectomy in Implant-Based Breast Reconstruction Revision Surgery Breast J. (IF 2.1) Pub Date : 2024-2-27 Pietro Susini, Gianluca Marcaccini, Francesco Ruben Giardino, Mirco Pozzi, Francesco Volanti, Giuseppe Nisi, Roberto Cuomo, Luca Grimaldi
Background. Breast cancer with about 2.3 million diagnoses and 685,000 deaths globally is the most frequent malignancy in the female population. Continuous research has led to oncological and reconstructive advances in the management of breast cancer, thus improving outcomes and decreasing patient morbidity. Nowadays, the submuscular expander and prosthesis (E/P) implant-based breast reconstruction
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Mammoplasty Using Modified Superomedial Pedicle Technique in Severely Macromastia and Ptotic Breasts Breast J. (IF 2.1) Pub Date : 2024-2-15 Engin Selamioğlu, Özgür Agdoğan
Mammoplasty is a surgery commonly used for macromastia. Many mammoplasty techniques are described, all with their specific pros and cons. However, the concern to avoid serious complications sometimes takes precedence, and the ideal result cannot be. For macromastia and severely ptotic breasts, usually the free nipple-areolar complex (NAC) mammoplasty technique is implemented. The results, however,
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Idiopathic Granulomatous Mastitis Breast J. (IF 2.1) Pub Date : 2024-1-25 Christina Dilaveri, Amy Degnim, Christine Lee, Daniel DeSimone, Dan Moldoveanu, Karthik Ghosh
Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this condition is noninfectious, but many cases are noted to be associated with Corynebacterium species. Most patients affected are parous women with a mean age of 35, and
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A Single-Center 18-Year Series of 73 Cases of Metaplastic Carcinoma of the Breast Breast J. (IF 2.1) Pub Date : 2024-1-4 Kassandra Thériault, Mariem Ben Moussa, Marjorie Perron, Christine Desbiens, Brigitte Poirier, Éric Poirier, Dominique Leblanc, Claudya Morin, Julie Lemieux, Jean-Charles Hogue, Dominique Boudreau
Aim. To examine the clinical management of metaplastic breast cancer (MeBC), particularly the role of chemotherapy. Methods. This retrospective study included patients with MeBC (n = 73) from a tertiary breast cancer center: the “Centre des Maladies du Sein of the CHU de Québec–Université Laval.” The specimens were reviewed by two pathologists. Patient and tumor characteristics, systemic therapy (neoadjuvant
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Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk Breast J. (IF 2.1) Pub Date : 2023-12-27 Ji-Eun Song, Ji Young Jang, Kyung Nam Kang, Ji Soo Jung, Chul Woo Kim, Ah Sol Kim
The objective of this study was to determine whether multi-microRNA analysis using a combination of four microRNA biomarkers (miR-1246, 202, 21, and 219B) could improve the diagnostic performance of mammography in determining breast cancer risk by age group (under 50 vs. over 50) and distinguish breast cancer from benign breast diseases and other cancers (thyroid, colon, stomach, lung, liver, and cervix
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Evaluation of a Surgical Navigation System for Localization and Excision of Nonpalpable Lesions in Breast and Axillary Surgery Breast J. (IF 2.1) Pub Date : 2023-12-23 Kjirsten A. Carlson, Cristina Checka, Kelly K. Hunt, Jennifer Jung, Christian Bridges, Puneet Singh, Ana Refinetti, Tanya Moseley, Frances Perez, Cody Mayo, Nina Tamirisa
Introduction. Elucent Medical has introduced a novel EnVisio™ Surgical Navigation system which uses SmartClips™ that generate a unique electromagnetic signal triangulated in 3 dimensions for real-time navigation. The purpose of this study was to evaluate the efficacy and feasibility of the EnVisio Surgical Navigation system in localizing and excising nonpalpable lesions in breast and axillary surgery
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MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells Breast J. (IF 2.1) Pub Date : 2023-12-1 Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing Lu
Breast cancer is considered the most prevalent malignancy due to its high incidence rate, recurrence, and metastasis in women that makes it one of the deadliest cancers. The current study aimed to predict the genes associated with the recurrence and metastasis of breast cancer and to validate their effect on MDA-MB-231 cells. Through the bioinformatics analysis, the transcription factor 7 cofactor
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The Clinicopathological Features and Prognostic Significance of HER2-Low in Early Breast Tumors Patients Prognostic Comparison of HER-Low and HER2-Negative Breast Cancer Stratified by Hormone Receptor Status Breast J. (IF 2.1) Pub Date : 2023-11-30 Sanaa Gamrani, Laila Akhouayri, Sara Boukansa, Mehdi Karkouri, Hinde El Fatemi
Introduction. There has been increased interest in HER2-low breast tumors recently, as these tumors may have distinct clinical and molecular characteristics compared to HER2-negative and HER2-positive tumors. A new nomenclature has been proposed for HER2 1+ and HER2 2+ tumors that are confirmed negative according to fluorescence in situ hybridization (FISH). These tumors are now referred to as HER2-low
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The Association between ER, PR, HER2, and ER−/PR+ Expression and Lung Cancer Subsequent in Breast Cancer Patients: A Retrospective Cohort Study Based on SEER Database Breast J. (IF 2.1) Pub Date : 2023-11-11 Hong Yu Shao, Bao Tan Hao, Feng Xiao Gao
Aims. The available research on the association between estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), ER−/PR+ status, and the occurrence of lung cancer subsequent to breast cancer in patients (referred to as BC-LuC) had been limited. Consequently, there is a need to examine whether ER, PR, HER2, and ER−/PR+ have independent correlations with the
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Human-Mimic Submuscular and Premuscular Irradiated Rat Model: Histologic Characteristics of the Capsule Tissue in Contact with the Breast Implant Breast J. (IF 2.1) Pub Date : 2023-11-9 Hyung Bae Kim, Se Young Han, Jin Sup Eom, Hyun Ho Han
Background. In this study, we established two rat models that mimic human submuscular and premuscular breast reconstruction. We analyzed the capsule formation according to surgical techniques and adjacent tissues, including the chest wall tissues, such as the ribs and acellular dermal matrices (ADMs) that come in contact with silicone implants. Methods. This study consisted of experiments on 12 Sprague–Dawley
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Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women Breast J. (IF 2.1) Pub Date : 2023-10-17 Hannah Lui Park, Argyrios Ziogas, Stephen A. Feig, Roza Lorin Kirmizi, Christie Jiwon Lee, Andrea Alvarez, Rachel McFarland Lucia, Deborah Goodman, Kathryn M. Larsen, Richard Kelly, Hoda Anton-Culver
Background. Breast density is an important risk factor for breast cancer and is known to be associated with characteristics such as age, race, and hormone levels; however, it is unclear what factors contribute to changes in breast density in postmenopausal women over time. Understanding factors associated with density changes may enable a better understanding of breast cancer risk and facilitate potential
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Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis: A Systematic Review Breast J. (IF 2.1) Pub Date : 2023-9-26 Asieh Sadat Fattahi, Ghasem Amini, Fatemeh Sajedi, Hassan Mehrad-Majd
Idiopathic granulomatous mastitis is a rare and benign disease that primarily affects young women of reproductive age. Various factors have been suggested as possible causes, including pregnancy, breastfeeding, history of taking birth control pills, hyperprolactinemia, smoking, and history of trauma. Due to unknown etiology, opinions on its treatment have varied, resulting in differing recurrence rates
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Return to Activities of Daily Living after Breast Cancer Surgery: An Observational Prospective Questionnaire-Based Study of Patients Undergoing Mastectomy with or without Immediate Reconstruction Breast J. (IF 2.1) Pub Date : 2023-9-20 L. Ballance, R. L. Wilson, C. C. Kirwan, G. Boundouki, V. P. Taxiarchi, B. G. Baker, V. Rusius, M. Rowland, J. R. Henderson, N. Marikakis, J. McAleer, J. R. Harvey, On Behalf of the Northwest Breast Research Collaborative
Background. Patients often ask about the time taken to return to activities of daily living (ADLs) after breast surgery, but there is a lack of data to give accurate guidance. We aimed to assess the feasibility of a study to determine the time taken to return to ADLs after mastectomy with or without breast reconstruction. Materials and Methods. A prospective multicentre, self-reported questionnaire-based
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Benign Phyllodes Tumors: Comparison of Prognosis among Three Different Surgical Approaches Breast J. (IF 2.1) Pub Date : 2023-9-20 Ying Jiang, Bo Wang, Jun Kang Li, Shi Yu Li, Rui Lan Niu, Nai Qin Fu, Jiao Jiao Zheng, Gang Liu, Zhi Li Wang
Purpose. To evaluate the prognosis of patients with benign phyllodes tumors (PTs) treated by different surgical methods and to explore the influencing factors of local recurrence. Methods. We retrospectively analyzed 215 benign PTs from 193 patients who underwent surgery at Chinese PLA General Hospital between October 2008 and December 2020. We stratified our analysis according to surgical factors
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LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17 Breast J. (IF 2.1) Pub Date : 2023-9-7 Chanjiao Yao, Lingjuan Zeng, Qin Liu, Xiaoxin Qiu, Chunyan Chen
Objective. This study aimed to explore the roles and mechanisms of lncRNA FAM225B and PDIA4 in ovarian cancer. Methods. RT-qPCR and Western blot assays were performed to detect the expression levels of the lncRNAs FAM225B, DDX17, and PDIA4 in the serum of patients with ovarian cancer and cell lines. Cells were transfected with lncRNA FAM225B- and PDIA4-related vectors to determine the malignant phenotypes
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Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4 Breast J. (IF 2.1) Pub Date : 2023-9-6 Meng Zhang, Mei Wang, Zhiming Jiang, Ziyi Fu, Jingjing Ma, Sheng Gao
Tamoxifen is a drug used for treating breast cancer (BC), especially for individuals diagnosed with estrogen receptor-positive (ER+) BC. Its prolonged use could reduce the risk of recurrence and significantly lengthen the survival rate of BC patients. However, an increasing number of patients developed resistance to tamoxifen treatment, which reduced therapeutic efficiency and caused substandard prognosis
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Evaluating Low HER2 Status in Invasive Breast Carcinoma via HER2 Immunohistochemistry, with HER2 FISH Correlation: A Cohort of 112 Patients Breast J. (IF 2.1) Pub Date : 2023-8-25 Gokce Deniz Ardor, Miglena K. Komforti, Helena Hanna, Onur Ibanoglu, Abigail Lochala, Aziza Nassar
Introduction. Recent trials demonstrated clinically significant benefits in HER2-nonamplified breast cancer with HER2-low expression using novel anti-HER2 antibody-drug conjugates. Thus, HER2-low breast cancer was proposed as a separate diagnostic entity. Herein, we reclassify HER2-negative cancers according to the new HER2-low category using a modified system and further investigate HER2-very-low
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Hormonal-Receptors-Positive and HER2-Negative Patients with Metastatic Breast Cancer Treated with First-Line Palbociclib and Hormonal Therapy: Impact of First-Cycle Neutropenia and Dose Reduction on Therapeutic Outcome Breast J. (IF 2.1) Pub Date : 2023-8-25 Khaled Abd Elaziz Ahmed Elnaghi, Hosam Ali Alghanmi, Shereef Ahmed Elsamany, Fathia Almarzoki, Mohamed Elsafty, Mohammad Jaffal
Background. CDK 4/6 inhibitors with hormonal therapy are the standard first-line therapy in metastatic hormonal receptors (HR)-positive and HER2-negative breast cancer. This study aims to assess the impact of neutropenia with 1st cycle, dose reduction, HER2-low status, and other clinicopathological factors on survival outcomes with the first-line palbociclib and hormonal therapy. Patients and Methods
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Effectiveness of Carbon Localization for Invasive Breast Cancer: An Institutional Experience Breast J. (IF 2.1) Pub Date : 2023-7-18 Etienne El-Helou, Christine Eddy, Simona Picchia, Carine Van de Merckt, Magali Radermeker, Michel Moreau, Filip De Neubourg, Denis Larsimont, Isabelle Veys, C. Florin Pop
Introduction. The final oncological and aesthetic results of breast-conserving surgery (BCS) are influenced by the precise localization of breast cancer (BC) tumors and by the quality of the intraoperative margin assessment technique. This study aimed to assess the effectiveness of the carbon localization (CL) technique by determining the success rate of BC identification and the proportion of adequate
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The Efficacy of Low-Kilovoltage X-Rays Intraoperative Radiation as Boost for Breast Cancer: A Systematic Review and Meta-Analysis Breast J. (IF 2.1) Pub Date : 2023-7-3 Yuanjian Fan, Ruiwan Chen, Ying Lu, Ying Lin, Yunjian Zhang, Nan Shao, Shenming Wang, Dahong Nie, Zhen Shan
Background. Intraoperative radiotherapy (IORT) is a novel promising technology that may replace external beam radiation therapy (EBRT) as boost for patients receiving breast-conserving surgery. To better evaluate the efficacy of IORT using low-kilovoltage (low-kV) X-rays as boost, we presented this meta-analysis according to the PRISMA checklist. Methods. Studies reported survival outcomes of intraoperative
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Impact of CDK4/6 Inhibitors on Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS) in the Adjuvant Setting Breast J. (IF 2.1) Pub Date : 2023-5-31 Efthymia Skafida, Angeliki Andrikopoulou, Evangelos Terpos, Christos Markellos, Savvina Moustafa, Dimitrios Pectasides, Meletios-Athanasios Dimopoulos, Flora Zagouri, Dimitrios Vassilopoulos
Background. Third-generation aromatase inhibitors (AIs) are the mainstay of treatment in hormone receptor (HR)-positive breast cancer. Even though it is considered to be a well-tolerated therapy, AI-induced musculoskeletal symptoms are common and may be accused for treatment discontinuation. Recently, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors changed the therapeutic setting, and
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The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres Breast J. (IF 2.1) Pub Date : 2023-5-9 Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio
Purpose. In modern breast cancer treatment, a growing role has been observed for breast reconstruction together with an increase in clinical indications for postmastectomy radiotherapy (PMRT). Choosing the optimum type of reconstructive technique is a clinical challenge. We therefore conducted a national multicenter study to analyze the impact of PMRT on breast reconstruction. Methods. We conducted
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Management of Lobular Neoplasia Diagnosed by Core Biopsy Breast J. (IF 2.1) Pub Date : 2023-4-18 Chinmay Jani, Margaret Lotz, Sarah Keates, Yasha Gupta, Alexander Walker, Omar Al Omari, Arshi Parvez, Dipesh Patel, Maria Gnata, John Perry, Leila Khorashadi, Lisa Weissmann, Susan E. Pories
Lobular neoplasia (LN) involves proliferative changes within the breast lobules. LN is divided into lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH). LCIS can be further subdivided into three subtypes: classic LCIS, pleomorphic LCIS, and LCIS with necrosis (florid type). Because classic LCIS is now considered as a benign etiology, current guidelines recommend close follow-up
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Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer Breast J. (IF 2.1) Pub Date : 2023-4-5 Liying Zhang, Jisen Hao, Jia Guo, Xin Zhao, Xing Yin
Objectives. To investigate the association between quantitative parameters generated using synthetic magnetic resonance imaging (SyMRI) and diffusion-weighted imaging (DWI) and Ki-67 expression level in patients with invasive ductal breast cancer (IDC). Method. We retrospectively reviewed the records of patients with IDC who underwent SyMRI and DWI before treatment. Precontrast and postcontrast relaxation
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MYL5 as a Novel Prognostic Marker is Associated with Immune Infiltrating in Breast Cancer: A Preliminary Study Breast J. (IF 2.1) Pub Date : 2023-2-17 Minghe Lv
Background. Myosin light chain plays a vital regulatory function in a large-scale cellular physiological procedure, however, the role of myosin light chain 5 (MYL5) in breast cancer has not been reported. In this study, we aimed to elucidate the effects of MYL5 on clinical prognosis and immune cell infiltration, and further explore the potential mechanism in breast cancer patients. Methods. In this
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The Oncologic Safety of Sentinel Lymph Node Biopsy in Patients with Node-Positive Breast Cancer with Complete Response to Neoadjuvant Chemotherapy: A Single-Center Experience Breast J. (IF 2.1) Pub Date : 2023-1-4 Ismail Can Tercan, Baha Zengel, Ozlem Ozdemir, Demet Cavdar, Funda Tasli, Zehra Hilal Adibelli, Murat Karatas, Cenk Simsek, Isabel Raika Durusoy, Adam Uslu
Objective. To evaluate the efficiency and safety of sentinel lymph node biopsy (SLNB) in patients with breast cancer with complete response to neoadjuvant chemotherapy (NAC). Methods. Ninety-two consecutive (T1-4 and N1-2) patients with breast cancer who had pathologic and/or clinical and radiologic axillary lymph node involvement were included. All patients received NAC. Patients with a clinical and
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Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1/2: Overall Survival, Racial, and Ethnic Differences Breast J. (IF 2.1) Pub Date : 2022-12-31 Sukh Makhnoon, Angelica M. Gutierrez Barrera, Roland Bassett, Aimaz Afrough, Isabelle Bedrosian, Banu K. Arun
Background. Patients with unilateral breast cancer carrying pathogenic variants in BRCA1/2 have the option to undergo contralateral prophylactic mastectomy (CPM). However, differences in CPM use and survival outcomes following CPM are poorly understood in this high-risk population, in part due to a lack of data from contemporary clinical cohorts. The objective of this study was to evaluate post-CPM
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Clinical Features and Prognosis Analysis of Hormone Receptor-Positive, HER2-Negative Breast Cancer with Differential Expression Levels of Estrogen and Progesterone Receptors: A 10-Year Retrospective Study Breast J. (IF 2.1) Pub Date : 2022-11-29 Jin Liu, Mingyu Gan, Zijing Lin, Qin Deng, Juan Deng, Bin Zeng, Yanling Shi, Jia Ming
Background. Estrogen and progesterone receptor status can predict breast cancer patient prognosis and treatment sensitivity, but research on low ER and PR levels and expression balance remains limited. Methods. From January 2010 to October 2016, 283 ER+/PR+/HER2-breast cancer patients who met the inclusion criteria were enrolled and divided into the H group (ER > 10%, N = 261) and the L group (1% ≤ ER ≤ 10%
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Associations between Physical Exercise, Quality of Life, Psychological Symptoms and Treatment Side Effects in Early Breast Cancer Breast J. (IF 2.1) Pub Date : 2022-11-19 Leena Vehmanen, Johanna Mattson, Evangelos Karademas, Albino J. Oliveira-Maia, Berta Sousa, Ruth Pat-Horenczyk, Ketti Mazzocco, Panagiotis Simos, Fátima Cardoso, Greta Pettini, Chiara Marzorati, Eleni Kolokotroni, Georgios Stamatakos, Diana Frasquilho, Paula Poikonen-Saksela
Background. Identifying and understanding modifiable factors for the well-being of cancer patients is critical in survivorship research. We studied variables associated with the exercise habits of breast cancer patients and investigated if the achievement of exercise recommendations was associated with enhanced quality of life and/or psychological well-being. Material and Methods. 311 women from Finland
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Preserving Nipple Sensitivity after Breast Cancer Surgery: A Systematic Review and Meta-Analysis Breast J. (IF 2.1) Pub Date : 2022-11-19 Varsha Harish, Zoe K. Haffner, Jenna C. Bekeny, Adaah A. Sayyed, David H. Song, Kenneth L. Fan
Purpose. As breast-conserving procedures become increasingly safe and viable options for surgical management of breast cancer, efforts have focused on assessing and optimizing patient-reported outcome measures (PROMs), such as nipple sensation. This study aims to evaluate the current understanding of nipple-areolar complex (NAC) sensation outcomes in breast cancer patients undergoing breast cancer
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Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program Breast J. (IF 2.1) Pub Date : 2022-10-31 Yik Shuen Chan, Wai Ka Hung, Lok Wa Yuen, Ho Yan Yolanda Chan, Chiu Wing Winnie Chu, Polly Suk Yee Cheung
Background. We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program. Methods. Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the
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Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among BRCA1/BRCA2 Mutation Carriers Breast J. (IF 2.1) Pub Date : 2022-10-27 Renata Faermann, Eitan Friedman, Orit Kaidar-Person, Jonathan Weidenfeld, Malka Brodsky, Anat Shalmon, Osnat Halshtok Neiman, Michael Gotlieb, Yael Yagil, David Samoocha, Dana Madorsky Feldman, Miri Sklair-Levy
Background. While BRCA1/BRCA2 pathogenic sequence variants (PSVs) clearly confer an increased risk for invasive breast cancer, the extent to which these mutant alleles increase DCIS risk is less clear. Objective. To assess the rate of detection over a 5-year period, and MRI imaging features of pure noncalcified DCIS in a cohort of Israeli BRCA1/BRCA2 PSV carriers attending a high-risk clinic from 2015
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Endoscopic Nipple- or Skin-Sparing Mastectomy and Immediate Breast Reconstruction with Endoscopic Harvesting of the Latissimus Dorsi Flap: A Preliminary Experience of an Innovative Technique Breast J. (IF 2.1) Pub Date : 2022-10-27 Yu Feng, Nan Wen, Faqing Liang, Jiao Zhou, Xiangquan Qin, Xinran Liu, Juan Li, Mengxue Qiu, Huanzuo Yang, Zhenggui Du
Background. Endoscopic nipple- or skin-sparing mastectomy (E-N/SSM) and endoscopic latissimus dorsi muscle flap (E-LDMF) harvest have been operational difficulties over decades. The aim of this study was to describe the preliminary outcomes of our novel surgical technique, which allows the performance of E-N/SSM and E-LDMF harvest for immediate breast reconstruction (IBR) through a single cosmetic
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Useful Reduction Mammoplasty Technique in Oncoplastic Breast Surgery and Reconstruction Breast J. (IF 2.1) Pub Date : 2022-10-21 Jong Ho Lee, Jeong Yeop Ryu, Kang Young Choi, Jung Dug Yang, Ho Yun Chung, Byung Chae Cho, Byeongju Kang, Jeeyeon Lee, Ho Yong Park, Joon Seok Lee
Background. A combination of the reduction mammoplasty technique and breast reconstruction allows surgeons to lift ptotic breasts through local flaps and skin reduction during surgery for breast cancer. This study presents a reliable course for the combination of partial and skin or nipple-sparing mastectomy with reduction-reconstruction surgery. Methods. Fifty-seven patients underwent a partial mastectomy
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Breast Cancer Epidemiology and Survival Analysis of Shenyang in Northeast China: A Population-Based Study from 2008 to 2017 Breast J. (IF 2.1) Pub Date : 2022-10-18 Hongbo Su, Xun Li, Yi Lv, Xueshan Qiu
Background. To investigate the status of breast cancer incidence, trends, and survival in women in urban Shenyang from 2008–2017 using large Cancer Registry data. Methods. Breast cancer incidence and mortality data were abstracted from the Shenyang Cancer Registry between 2008 and 2017. The crude and age-standardized incidence and mortality rates were calculated for each year. Average annual percentage
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The Importance of the Pathological Perspective in the Management of the Invasive Lobular Carcinoma Breast J. (IF 2.1) Pub Date : 2022-9-26 Funda Tasli, Demet Cavdar, Sibel Demir Kececi, Baha Zengel, Zehra Hilal Adibelli, Gamze Dal, Irem Gonen, Ozden Oz, Cengiz Yilmaz, Ozlem Ozdemir, Hulya Mollamehmetoglu, Ismail Dilek, Enver Ilhan, Adam Uslu
Background. Invasive lobular carcinomas (ILC) account for 10–15% of all breast cancers and are the second most common histological form of breast cancer. They usually show a discohesive pattern of single cell infiltration, tend to be multifocal, and the tumor may not be accompanied by a stromal reaction. Because of these histological features, which are not common in other breast tumors, radiological
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Bacitracin for Injection Recall: Impact on Immediate Breast Implant Surgical Outcomes Breast J. (IF 2.1) Pub Date : 2022-08-31 Abigail R. Tirrell, Jenna C. Bekeny, Eshetu A. Tefera, David H. Song, Kenneth L. Fan
Background. Triple-antibiotic irrigation of breast implant pockets is a mainstay of infection prophylaxis in breast reconstruction and augmentation. The recall of bacitracin for injection due to risk of anaphylaxis and nephrotoxicity in January 2020, a staple component of the irrigation solution, has raised concern for worsened postoperative sequelae. This study aimed to investigate pre- and post-recall
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Hospital Rurality and Gene Expression Profiling for Early-Stage Breast Cancer among Iowa Residents (2010–2018) Breast J. (IF 2.1) Pub Date : 2022-08-30 Danielle Riley, Mary Charlton, Elizabeth A. Chrischilles, Ingrid M. Lizarraga, Sneha Phadke, Brian J. Smith, Adam Skibbe, Charles F. Lynch
Objective. Given the challenges rural cancer patients face in accessing cancer care as well as the slower diffusion and adoption of new medical technologies among rural providers, the aim of our study was to examine trends in gene expression profiling (GEP) testing and evaluate the association between hospital rurality and receipt of GEP testing. Methods. Data from the Iowa Cancer Registry (ICR) were
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Nontherapeutic Risk Factors of Different Grouped Stage IIIC Breast Cancer Patients’ Mortality: A Study of the US Surveillance, Epidemiology, and End Results Database Breast J. (IF 2.1) Pub Date : 2022-08-30 Yue Qiu, Hongye Chen, Yongjing Dai, Baoshi Bao, Lin Tian, Yuhui Chen
Objectives. Stage IIIC breast cancer, as a local advanced breast cancer, has a poor prognosis compared with that of early breast cancer. We further investigated the risk factors of mortality in stage IIIC primary breast cancer patients and their predictive value. Methods. We extracted data from the US Surveillance, Epidemiology, and End Results (SEER) database of female patients with stage IIIC primary
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RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway Breast J. (IF 2.1) Pub Date : 2022-08-28 Tao Song, Huazhou Zhang
Background. Breast cancer (BC) is the most prevalent malignancy in women. This study is aimed to explore the role and regulatory mechanism of RNA-binding motif protein 8A (RBM8A) in BC. Methods. We detected the expression of RBM8A in BC tissues and cell lines (MCF-7, MDA-MB-231, and MDA-MB-436), and explored the correlation of RBM8A expression with clinicopathological features in patients. The function
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Survival Outcomes of Breast-Conserving Therapy versus Mastectomy in Early-Stage Breast Cancer, Including Centrally Located Breast Cancer: A SEER-Based Study Breast J. (IF 2.1) Pub Date : 2022-08-27 Tianshui Yu, Weilun Cheng, Ting Wang, Ziang Chen, Yu Ding, Jianyuan Feng, Yunqiang Duan, Anbang Hu, Mingcui Li, Hanyu Zhang, Yanling Li, Fei Ma, Baoliang Guo
Purpose. This study aims to analyze the survival outcomes of breast cancer (BC) patients, especially centrally located breast cancer (CLBC) patients undergoing breast-conserving therapy (BCT) or mastectomy. Methods. Surveillance, epidemiology, and end results (SEER) data of patients with T1-T2 invasive ductal or lobular breast cancer receiving BCT or mastectomy were reviewed. We used X-tile software
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Exploring the Value of Additional Primary Tumour Excision Combined with Systemic Therapy Administered in Different Sequences for Patients with de Novo Metastatic Breast Cancer Breast J. (IF 2.1) Pub Date : 2022-08-25 Siyi Zhu
Introduction. Uncertainty still remains regarding the survival improvement derived from immediate surgery or subsequent surgery in addition to systemic therapy for patients with de novo metastatic breast cancer. The current study aimed to examine the effect of combined treatment administered in different sequences on the survival of these patients. Materials and Methods. We conducted a retrospective
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Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma Breast J. (IF 2.1) Pub Date : 2022-08-22 Yue Qiu, Yuhui Chen, Li Zhu, Hongye Chen, Yongjing Dai, Baoshi Bao, Lin Tian, Xiaopeng Hao, Jiandong Wang
Introduction. Metaplastic breast carcinoma is a rare special type of breast cancer, which has distinguished clinical characteristics. We aimed to evaluate the clinicopathological features of metaplastic breast carcinoma compared with nonspecific invasive breast carcinoma and study the prognosis of metaplastic breast carcinoma. Methods. We reviewed metaplastic breast carcinoma cases (n = 37) from January
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Breast Cancer Patients with Brain Metastases: A Cross-Sectional Study Breast J. (IF 2.1) Pub Date : 2022-08-19 Melih Simsek, Altay Aliyev, Tuba Baydas, Mehmet Besiroglu, Tarik Demir, Abdallah TM Shbair, Mesut Seker, H. Mehmet Turk
The prognosis of breast cancer patients with brain metastasis is poor. It was aimed to define the clinicopathological features of breast cancer patients with brain metastases and to determine the risk factors and survival outcomes associated with brain metastasis. This is a single-center, retrospective, cross-sectional study. A total number of 127 patients diagnosed with breast cancer and who developed
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Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast Breast J. (IF 2.1) Pub Date : 2022-08-12 Shifei Liu, Rui Yuan, Yulan Jin, Chunyan He, Xingzheng Zheng, Yang Zhan
Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. Because of the lack of typical imaging and clinical characteristics of IMT, it is easy to misdiagnose before operation. We now report a case of a 37-year-old woman presenting with a mass in her left breast. Ultrasound showed a well-circumscribed lesion in the
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Evaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk Breast J. (IF 2.1) Pub Date : 2022-08-11 Kala Visvanathan, Ashley Cimino-Mathews, Mary Jo Fackler, Pritesh S. Karia, Christopher J. VandenBussche, Mikiaila Orellana, Betty May, Marissa J. White, Mehran Habibi, Julie Lange, David Euhus, Vered Stearns, John Fetting, Melissa Camp, Lisa Jacobs, Saraswati Sukumar
Introduction. Critical regulatory genes are functionally silenced by DNA hypermethylation in breast cancer and premalignant lesions. The objective of this study was to examine whether DNA methylation assessed in random fine needle aspirates (rFNA) can be used to inform breast cancer risk. Methods. In 20 women with invasive breast cancer scheduled for surgery at Johns Hopkins Hospital, cumulative methylation
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Accuracy and Limitations of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer Patients with Positive Nodes Breast J. (IF 2.1) Pub Date : 2022-08-05 Sofia Aragon-Sanchez, M. Reyes Oliver-Perez, Ainhoa Madariaga, M. Jose Tabuenca, Mario Martinez, Alberto Galindo, M. Luisa Arroyo, Marta Gallego, Marta Blanco, Eva M. Ciruelos-Gil
Background. Axillary surgical management in patients with node-positive breast cancer at the time of diagnosis converted to negative nodes through neoadjuvant chemotherapy (NAC) remains unclear. Removal of more than two sentinel nodes (SLNs) in these patients may decrease the false negative rate (FNR) of sentinel lymph node biopsies (SLNBs). We aim to analyse the detection rate (DR) and the FNR of
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Luminal A Breast Cancer: How Feasible is Omitting Axillary Dissection Without Neoadjuvant Therapy Breast J. (IF 2.1) Pub Date : 2022-07-30 Cemil Yüksel, Bülent Aksel, Lütfi Doğan
Background. Luminal A breast cancer has a good prognosis and the criteria for adjuvant and neoadjuvant chemotherapy (NAC) are not clear. The aim of this study was to present our results of upfront surgery and long-term survival in luminal A tumors as well as the rates of protection from axillary dissection. Material and Methods. 271 Luminal A breast cancer patients who had operated at our center were
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A Prospective Double-Blinded Randomized Controlled Trial Comparing the Intraoperative Injection of Technetium Tc 99m Tilmanocept with Technetium Tc 99m Sulfur Colloid in Breast Cancer Lymphatic Mapping Breast J. (IF 2.1) Pub Date : 2022-07-30 Anyul Ferez-Pinzon, Samuel L. Corey, Haresh Rochani, Elena A. Rehl, William E. Burak Jr
Introduction. Technetium-labeled sulfur colloid (TSC) is a radiolabeled mapping agent commonly used for sentinel lymph node biopsy (SLNBx). Tilmanocept, a CD206 receptor-targeted mapping agent, has gained recent popularity due to potential advantages of rapid and quick uptake to the SLNs. The objectives of this study were to assess (1) the difference in the number of SLNs harvested using tilmanocept
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Evaluation of Axillary Lymph Node Marking with Magseed® before and after Neoadjuvant Systemic Therapy in Breast Cancer Patients: MAGNET Study Breast J. (IF 2.1) Pub Date : 2022-07-09 María Martínez, Sara Jiménez, Florentina Guzmán, Marta Fernández, Elena Arizaga, Consuelo Sanz
Background. Due to the high false negative rate (FNR) associated with sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST), the standard surgical treatment for patients with an initially positive axilla and indicated for NAST is axillary lymph node dissection (ALND). To avoid unnecessary ALND, this multicenter, prospective, observational study aimed to determine the effectiveness
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Analysis of Clinicopathological Characteristics and Prognosis of Carcinosarcoma of the Breast Breast J. (IF 2.1) Pub Date : 2022-07-01 Yao Tian, Xiaofeng Liu, Yingxi Li, Qingxiang Meng, Yumian Jia, Baichuan Wang, Xianghui He
Background. Few cases of carcinosarcoma of the breast have been reported because of its low incidence rate and rapid progression. Seeking effective therapeutic methods becomes urgent in clinical practice. This study was aimed to investigate the clinical characteristics of carcinosarcoma of the breast and to explore proper therapeutic methods for patients with this rare tumor. Methods. We conducted
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Neoadjuvant Trastuzumab and Pertuzumab for Early HER2-Positive Breast Cancer: A Real World Experience Breast J. (IF 2.1) Pub Date : 2022-06-30 Benjamin James Hall, Ajay Ashok Bhojwani, Helen Wong, Andrea Law, Helen Flint, Eliyaz Ahmed, Helen Innes, Joanne Cliff, Zaf Malik, Julie Elizabeth O’Hagan, Allison Hall, Rajaram Sripadam, Shaun Tolan, Zulfiqar Ali, Clare Hart, Douglas Errington, Farida Alam, Rosa Giuliani, Shaveta Mehta, Sheena Khanduri, Nicky Thorp, Richard Jackson, Silvia Cicconi, Carlo Palmieri
Background. Randomized studies of neoadjuvant (NA) trastuzumab and pertuzumab combined with chemotherapy for HER2-positive breast cancers (BC) have reported pathological complete response (pCR) rates of 39 to 61%. This study aimed to determine the real-world efficacy and toxicity of NA trastuzumab and pertuzumab combined with chemotherapy in a UK tertiary referral cancer centre. Methods. HER2-positive
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Morbidity of the Donor Site and Complication Rates of Breast Reconstruction with Autologous Abdominal Flaps: A Systematic Review and Meta-Analysis Breast J. (IF 2.1) Pub Date : 2022-06-24 Hatan Mortada, Taif Fawaz AlNojaidi, Razan AlRabah, Yousif Almohammadi, Raghad AlKhashan, Hattan Aljaaly
Background. Numerous studies have evaluated the use of autologous abdominal tissue for breast reconstruction; nevertheless, complications and donor site morbidity rates vary significantly. The study aims to compare the literature regarding morbidity of the donor site and complication rates of breast reconstruction with autologous abdominal flaps. Methods. The databases of MEDLINE, EBSCO, Scopus, Wiley
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The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators Breast J. (IF 2.1) Pub Date : 2022-06-01 L. J. van Zeelst, R. Derksen, C. H. W. Wijers, J. Hegeman, R. Berry, J. H. W. de Wilt, L. J. A. Strobbe
Background. The rate of inpatient mastectomies remains high despite multiple studies reporting favourably on outpatient mastectomies. Outpatient mastectomies do not compromise quality of patient care and are more efficient than inpatient care. The objective of this study was to evaluate the feasibility of outpatient mastectomy. Materials and Methods. Implementation of an outpatient mastectomy program
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Negative Impact of Vitamin D Deficiency at Diagnosis on Breast Cancer Survival: A Prospective Cohort Study Breast J. (IF 2.1) Pub Date : 2022-06-01 Benedito Souza Almeida-Filho, Michelle Sako Omodei, Daniel A. B. Buttros, Eduardo Carvalho-Pessoa, Carla Priscila Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas
Objective. We prospectively evaluated the association between vitamin D concentration at diagnosis and overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) in postmenopausal women treated for breast cancer. Methods. This study included 192 patients newly diagnosed with invasive breast cancer, aged ≥45 years, and serum 25-hydroxy vitamin D (25 (OH)D) concentration assessment
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The Accuracy of Electrical Impedance Tomography for Breast Cancer Detection: A Systematic Review and Meta-Analysis Breast J. (IF 2.1) Pub Date : 2022-05-26 Zahra Rezanejad Gatabi, Mehri Mirhoseini, Nasrin Khajeali, Iman Rezanezhad Gatabi, Maedeh Dabbaghianamiri, Sara Dorri
Introduction. Incidence of breast cancer (BC) in 2020 is about 2.26 million new cases. It is the first common cancer accounting for 11.7% of all cancer worldwide. Disease complications and the mortality rate of breast cancer are highly dependent on the early diagnosis. Therefore, novel human breast-imaging techniques play an important role in minimizing the breast cancer morbidity and mortality rate
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Development of the Breast Surgical Oncology Fellowship in the United States Breast J. (IF 2.1) Pub Date : 2022-05-19 Lauren Zammerilla Westcott, Ronald C. Jones, James W. Fleshman
The surgical treatment of breast cancer has rapidly evolved over the past 50 years, progressing from Halsted’s radical mastectomy to a public campaign of surgical options, aesthetic reconstruction, and patient empowerment. Sparked by the research of Dr. Bernard Fisher and the first National Surgical Adjuvant Breast and Bowel Project trial in 1971, the field of breast surgery underwent significant growth
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The Prognosis and Predictive Value of Estrogen Negative/Progesterone Positive (ER−/PR+) Phenotype: Experience of 1159 Primary Breast Cancer from a Single Institute Breast J. (IF 2.1) Pub Date : 2022-05-17 S. Gamrani, S. Boukansa, Z. Benbrahim, N. Mellas, F. Fdili Alaoui, M. A. Melhouf, C. Bouchikhi, A. Banani, M. Boubbou, T. Bouhafa, H. El Fatemi
Breast cancer is a serious worldwide public health problem and is currently the most common cancer overall. Its endocrine therapy is related to the expression of the steroid hormones, estrogen receptor (ER), and progesterone receptor (PR). Breast cancers can be presented under multiple profiles of steroid hormones: ER(−)/PR(+), ER(+)/PR(−), double-positive/negative ER, and PR. 2–8% of all breast cancers
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lncRNA LUCAT1/ELAVL1/LIN28B/SOX2 Positive Feedback Loop Promotes Cell Stemness in Triple-Negative Breast Cancer Breast J. (IF 2.1) Pub Date : 2022-05-12 Li Xia, Hao Wang
Background. Triple-negative breast cancer (TNBC), as a subtype of breast cancer (BC), features an aggressive nature. Long noncoding RNAs (lncRNAs) are proved to get involved in the processes of cancers. lncRNA lung cancer associated transcript 1 (LUCAT1) has been reported in multiple cancers. The role of LUCAT1 in TNBC and its latent regulatory mechanism were investigated. Methods. RT-qPCR was performed
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Comparing the Prognoses of Breast-Conserving Surgeries for Differently Aged Women with Early Stage Breast Cancer: Use of a Propensity Score Method Breast J. (IF 2.1) Pub Date : 2022-04-23 Shurui Bao, Guijin He
Background. To explore the effect of age on the prognosis of patients with early stage breast cancer after breast-conserving surgery (BCS) and to provide references for young patients. Methods. All clinical data of patients with early breast cancer undergoing BCS who were treated at Shengjing Hospital of China Medical University from January 2011 to May 2016 were obtained. The primary endpoints were