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Is my patient an appropriate candidate for sentinel node biopsy? Less axillary surgery, for the right patients. Critical review and grades of recommendation Surg. Oncol. (IF 2.3) Pub Date : 2024-03-15 Jordana De Faria Bessa, Guilherme Garcia Novita, Laura Testa, Ruffo Freitas-Junior, Gustavo Nader Marta
While general conclusions of historical trials are widely recognized, the nuances regarding precise indications of Sentinel Node Biopsy (SNB) in breast cancer in complex clinical scenarios often remain a source of debate and require further elucidation. Two reviewers (JFB and GNM) independently searched electronic databases for studies including SNB as the main intervention. Filters were applied to
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De-escalating axillary management after neoadjuvant chemotherapy in breast cancer: The ratio of positive sentinel lymph nodes matters Surg. Oncol. (IF 2.3) Pub Date : 2024-03-13 S. Aragón-Sánchez, R. Sánchez-Bayona, L. López-Marín, E. Ciruelos-Gil, L. Parrilla-Rubio, Pablo Zaragoza-Ballester, A. Galindo-Izquierdo, B. García-Chapinal, L. Álvaro-Valiente, M.R. Oliver-Pérez
De-escalation of axillary surgery in breast cancer (BC) patients diminishes sequelae without compromising cancer outcomes. Surgical management of the axilla is challenging after neoadjuvant treatment. We aimed to identify the factors associated with residual axillary disease amenable to lymphadenectomy in patients with positive sentinel lymph node biopsy (SLNB). We conducted a retrospective observational
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Debulking hepatectomy for colorectal liver metastasis: Analysis of risk factors for progression free survival Surg. Oncol. (IF 2.3) Pub Date : 2024-03-12 Alessandro D. Mazzotta, Nita Usdin, Diab Samer, Ecoline Tribillon, Brice Gayet, David Fuks, Christophe Louvet, Olivier Soubrane
The study explores the role of liver debulking surgery in cases of unresectable colorectal liver metastases (CRLM), challenging the traditional notion that surgery is not a valid option in such scenarios. Patients with advanced but resectable disease who underwent surgery with a curative intent (Group I) and those with advanced incompletely resectable disease who underwent a “debulking” hepatectomy
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Clinical characteristics and prognostic impact of direct distant organ metastasis in colorectal cancer Surg. Oncol. (IF 2.3) Pub Date : 2024-03-08 Ching-Heng Hsiao, Yen-Liang Li, Kee-Thai Kiu, Min-Hsuan Yen, Tung-Cheng Chang
Colorectal cancer (CRC) is the third most common type of cancer worldwide, and distant metastasis is frequently noted at diagnosis or follow-up. Notably, some patients with CRC can present with distant organ metastasis without any nodal involvement, which was defined as direct distant organ metastasis (DDOM). In this study, we evaluated the prognostic significance of DDOM for patients with CRC. This
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Development and external validation of a machine learning model for prediction of survival in extremity leiomyosarcoma Surg. Oncol. (IF 2.3) Pub Date : 2024-03-07 Austin Yu, Linus Lee, Thomas Yi, Michael Fice, Rohan K. Achar, Sarah Tepper, Conor Jones, Evan Klein, Neil Buac, Nicolas Lopez-Hisijos, Matthew W. Colman, Steven Gitelis, Alan T. Blank
Machine learning (ML) models have been used to predict cancer survival in several sarcoma subtypes. However, none have investigated extremity leiomyosarcoma (LMS). ML is a powerful tool that has the potential to better prognosticate extremity LMS. The Surveillance, Epidemiology, and End Results (SEER) database was queried for cases of histologic extremity LMS (n = 634). Patient, tumor, and treatment
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Association of preoperative and postoperative circulating tumour DNA (ctDNA) with PIK3CA gene mutation with risk of recurrence in patients with non-metastatic breast cancer Surg. Oncol. (IF 2.3) Pub Date : 2024-03-05 Fara Hassan, Jiang Huai Wang, Donal Peter O'Leary, Mark Corrigan, Henry Paul Redmond
Circulating tumour DNA (ctDNA), contains tumour-specific gene mutation in blood circulation and could aid in postoperative risk stratification of non-metastatic breast cancer. In this study, we investigated the feasibility of detecting PIK3CA gene mutations in ctDNA in the preoperative (preop) and postoperative period (postop), and its prognostic significance in patients with breast cancer. A cohort
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Key points for protecting the external branch of the superior laryngeal nerve in open thyroidectomy: A possible exploration technique Surg. Oncol. (IF 2.3) Pub Date : 2024-03-05 Hang Chen, Keyi Xu, Xueying Peng, Xiang Min
Injury of the external branch of the superior laryngeal nerve (EBSLN) is easily overlooked in thyroidectomy, and voice changes caused by the injury have a negative effect on an increasing number of patients. This study aimed to reduce the injury rate of EBSLN by expanding the sternothyroid-laryngeal triangle and standardizing the exploration procedure. A total of 520 patients who had undergone thyroidectomy
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The significance of resection margins on R0 results in intrahepatic cholangiocarcinoma Surg. Oncol. (IF 2.3) Pub Date : 2024-02-29 B.O. Stüben, S. Ahmadi, F.H. Saner, J. Li, J.P. Neuhaus, J.W. Treckmann, D.P. Hoyer
Intrahepatic cholangiocarcinoma is the second most common primary liver cancer after hepatocellular carcinoma with an increasing incidence worldwide. Surgical resection is still the only potential cure, and survival rates are dismal due to disease relapse after resection and/or metastatic disease. Positive resection margins are associated with recurrence, with conflicting studies regarding the benefits
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Interpectoral nerve blocks may lower postoperative narcotic use after mastectomy Surg. Oncol. (IF 2.3) Pub Date : 2024-02-16 Ricardo J. Bello, Benjamin A. Palleiko, Kara Kennedy, Lauren Cournoyer, Anne C. Larkin, Kate H. Dinh, Jennifer LaFemina
Pain management following mastectomy is a significant challenge often requiring opioids. Nonopioid pain management utilizing nerve blocks has been shown in other fields to reduce postoperative opioid use and may be effective for postoperative pain in mastectomy patients. The primary purpose of this study was to compare postoperative opioid use, measured in morphine milligram equivalents (MME), between
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Scarless totally implantable venous access port (TIVAP) implantation: Surgical technique, preliminary results, learning curve, and patients-reported outcome in 125 breast cancer patients Surg. Oncol. (IF 2.3) Pub Date : 2024-02-14 Yi-Lin Chang, Chayanee Sae-lim, Shih-Lung Lin, Hung-Wen Lai, Hsin-I Huang, Yuan-Chieh Lai, Shou-Tung Chen, Dar-Ren Chen
Minimal-access (endoscopic or robotic-assisted) breast surgery has been increasingly performed and shown better cosmetic results. However, location of totally implantable venous access port (TIVAP) for systemic treatment at anterior chest may compromise its aesthetic benefits. Therefore, we proposed a new scarless technique for TIVAP implantation, and reported the preliminary results, learning curve
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Differences in other-cause mortality in metastatic renal cell carcinoma according to partial vs. radical nephrectomy and age: A propensity score matched study Surg. Oncol. (IF 2.3) Pub Date : 2024-02-13 Carolin Siech, Reha-Baris Incesu, Simone Morra, Lukas Scheipner, Andrea Baudo, Letizia Maria Ippolita Jannello, Mario de Angelis, Jordan A. Goyal, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Derya Tilki, Nicola Longo, Luca Carmignani, Ottavio de Cobelli, Sascha Ahyai, Alberto Briganti, Philipp Mandel, Luis A. Kluth, Felix K.H. Chun, Pierre I. Karakiewicz
It is unknown whether the benefit from partial nephrectomy regarding lower other-cause mortality is applicable to older patients with metastatic renal cell carcinoma. Using Surveillance Epidemiology and End Results database, patients with metastatic renal cell carcinoma, undergoing partial or radical nephrectomy, were stratified according to age (<60, 60–69, and ≥70 years). After propensity score matching
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The impact of methylene blue in colorectal cancer: Systematic review and meta-analysis study Surg. Oncol. (IF 2.3) Pub Date : 2024-02-09 Alexandre Carvalho, Nuno Gonçalves, Pedro Teixeira, André Goulart, Pedro Leão
In patients with colorectal cancer (CRC), the most important factor to decide the need of adjuvant chemotherapy is the histological lymph node (LN) evaluation. Our work aimed to give a broad view over the use of methylene blue and its consequences in the number of lymph node harvest. PUBMED, WEB OF SCIENCE and EMBASE databases were consulted, retrieving clinical trials, which mentioned the used of
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Clinical implications of C-reactive protein–albumin–lymphocyte (CALLY) index in patients with esophageal cancer Surg. Oncol. (IF 2.3) Pub Date : 2024-02-05 Ruiya Ma, Yoshinaga Okugawa, Tadanobu Shimura, Shinji Yamashita, Yuhki Sato, Chengzeng Yin, Ryo Uratani, Takahito Kitajima, Hiroki Imaoka, Mikio Kawamura, Yuhki Morimoto, Yoshiki Okita, Shigeyuki Yoshiyama, Masaki Ohi, Yuji Toiyama
The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel inflammatory nutritional biomarker. This study aimed to investigate the potential clinical significance and oncological prognostic role of the preoperative CALLY index in patients with esophageal cancer. We analyzed the preoperative CALLY index in 146 patients with esophageal cancer. The CALLY index and clinicopathological variables
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Impact of low dose superparamagnetic iron oxide tracer for sentinel node biopsy in breast conserving treatment on susceptibility artefacts on magnetic resonance imaging and contrast enhanced mammography Surg. Oncol. (IF 2.3) Pub Date : 2024-02-05 Elisabeth R.M. van Haaren, Merel A. Spiekerman van Weezelenburg, James van Bastelaar, Alfred Janssen, Thiemo van Nijnatten, Lee H. Bouwman, Yvonne L.J. Vissers, Marc B.I. Lobbes
Residual particles of superparamagnetic iron oxide (SPIO) tracer, used for sentinel node biopsy, cause susceptibility artefacts on breast Magnetic Resonance Imaging (MRI). We investigated the impact of these artefacts on the imaging quality of MRI and explored whether contrast-enhanced mammography (CEM) could be an alternative in the follow-up of breast cancer patients. Data on patients’ characteristics
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Double hepatic vein reconstruction during extended anatomical resection of segment 8 for colorectal liver metastasis Surg. Oncol. (IF 2.3) Pub Date : 2024-01-30 Katsuya Sakashita, Shimpei Otsuka, Katsuhiko Uesaka, Teiichi Sugiura
Background Hepatic vein reconstruction (HVR) is occasionally necessary for resecting hepatic malignancies to ensure surgical margins while preserving remnant liver function (Nakamura et al., 1993) [1]. Reports of multiple HVR are rare due to the highly technical demanding procedure and high risk of morbidity (Wakabayashi et al., 1998) [2]. We introduce our procedure of double HVR for metastatic liver
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Osteosarcopenia impacts treatment outcomes for Barcelona Cancer Liver Classification stage A hepatocellular carcinoma Surg. Oncol. (IF 2.3) Pub Date : 2024-02-02 Kyohei Abe, Kenei Furukawa, Michinori Matsumoto, Yasuro Futagawa, Hironori Shiozaki, Shinji Onda, Koichiro Haruki, Yoshihiro Shirai, Tomoyoshi Okamoto, Toru Ikegami
To study the effect of preoperative osteosarcopenia (OSP) on the prognosis of treatment (surgery or radiofrequency ablation (RFA)) in patients with Barcelona Cancer Liver Classification stage A hepatocellular carcinoma (BCLC A HCC). This study enrolled 102 patients with BCLC A HCC who underwent surgical resection (n = 45) and RFA (n = 57); the patients were divided into two groups: OSP (n = 33) and
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A systematic review and meta-analysis of mediastinoscopy-assisted transhiatal esophagectomy (MATHE) Surg. Oncol. (IF 2.3) Pub Date : 2024-02-02 Yoshio Masuda, Eugene Kwong Fei Leong, Jimmy Bok Yan So, Asim Shabbir, Timothy Lam Jia Wei, Daryl Kai Ann Chia, Guowei Kim
Transhiatal esophagectomy (THE) avoids thoracotomy but sacrifices mediastinal lymphadenectomy. Mediastinoscopy-assisted transhiatal esophagectomy (MATHE) allows for visualisation and en-bloc dissection of mediastinal lymph nodes while retaining the benefits of THE. However, given its novel inception, there is a paucity of literature. This study aimed to conduct the first meta-analysis to explore the
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Introduction to “Legends in Oncology: Expert Commentary” Surg. Oncol. (IF 2.3) Pub Date : 2024-01-27 Vijay P. Khatri
Abstract not available
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Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID) Surg. Oncol. (IF 2.3) Pub Date : 2024-01-27 Adela Rojas-Holguín, Constantino Fondevila-Campo, Alfonso Sanjuanbenito, Joan Fabregat-Prous, Luís Secanella-Medayo, Fernando Rotellar-Sastre, Fernando Pardo-Sánchez, Mikel Prieto-Calvo, Héctor Marín-Ortega, Santiago Sánchez-Cabús, Luis Diez-Valladares, Óscar Alonso-Casado, Carmen González-Serrano, Juan Carlos Rodríguez-Sanjuan, Gabriel García-Plaza, Isabel Jaén-Torrejimeno, Miguel Ángel Suárez-Muñoz
Background and objectives Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival
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Relationship between immune checkpoint proteins and neoadjuvant chemotherapy response in breast cancer Surg. Oncol. (IF 2.3) Pub Date : 2024-01-24 Umut Kina Kilicaslan, Basak Aru, Sibel Aydin Aksu, Fugen Vardar Aker, Gulderen Yanikkaya Demirel, Meryem Gunay Gurleyik
Introduction Following major developments in cancer immunotherapy, treatments targeting immune checkpoint proteins (ICP) gained interest in breast cancer, though studies mostly focus on patients with metastatic disease as well as patients nonresponsive to the conventional treatments. Herein, we aimed to investigate the levels of ICP in tumor stroma and tumor infiltrating lymphocytes, and tumor tissue
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Clinical outcomes of total femoral replacement. First Latin American experience Surg. Oncol. (IF 2.3) Pub Date : 2024-01-22 Jorge Cabrolier, Oscar Ceballos, Fabiola Rieloff, Francisco Hardoy, Ricardo Tolosa, Orlando Wevar
Introduction The femur is frequently affected by primary and metastatic bone tumors. In cases with substantial bone loss, Total Femur Replacement (TFR) remains the only viable limb preservation option. This study investigates the clinical outcomes of TFR patients in a Latin American setting, with a minimum 3-year follow-up. Methods Retrospective review identifying cases of TFR at a single center from
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Hybrid technique has lower stricture rates than Wallace and Bricker Surg. Oncol. (IF 2.3) Pub Date : 2024-01-05 Osman Can, Eyyüp Danış, Eren Görkem Kutlutürk, Emre Can Polat, Alper Ötünçtemur
Introduction A clear consensus has not yet been reached on the optimal ureteroenteric anastomosis technique for ileal conduit urinary diversion following radical cystectomy. This study aims to determine the incidence of strictures and their management associated with these anastomosis techniques. Methods We conducted a retrospective, single-center study of patients who underwent radical cystectomy
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Improving accuracy in nodal staging of oral cancer: Proposal of a new system Surg. Oncol. (IF 2.3) Pub Date : 2024-01-05 Narayana Subramaniam, Gillian Heller, Jonathan Robert Clark, Ruta Gupta, David Goldstein, John R. de Almeida, Ali Hosni, Deepak Balasubramanian, Krishnakumar Thankappan, Subramania Iyer, Martin Batstone, N. Gopal Iyer, Robert I. Smee, Naveen Hedne Chandrasekhar, Vijay Pillai, Vivek Shetty, Vidyabhushan Rangappa, Michael Veness, Tsu-Hui (Hubert) Low
Background Despite introduction of extranodal extension (ENE) into the AJCC 8th edition of oral cancer staging, previous criticisms persist, such as limited discrimination between sub-stages and doubtful prognostic value of contralateral nodal disease. The purpose of this study was to compare our novel nodal staging system, based on the number of positive nodes and ENE, to the AJCC staging system in
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The prognosis-based classification model in resectable pancreatic cancer Surg. Oncol. (IF 2.3) Pub Date : 2024-01-05 Norimitsu Okui, Masashi Tsunematsu, Kenei Furukawa, Yoshihiiro Shirai, Koichiro Haruki, Taro Sakamoto, Tadashi Uwagawa, Shinji Onda, Takeshi Gocho, Toru Ikegami
Aim Pancreatic ductal adenocarcinoma treatment is mainly based on the anatomical resectability classification. However, prognosis-based classification may be more reasonable. In this study, we stratified resectable pancreatic ductal adenocarcinoma according to preoperative factors and reconsidered treatment strategies. Methods We retrospectively evaluated 131 patients who underwent upfront surgery
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Surgical outcomes and predictors of overall survival of stage I-III appendiceal adenocarcinoma: Retrospective cohort analysis of the national cancer database Surg. Oncol. (IF 2.3) Pub Date : 2024-01-05 Sameh Hany Emile, Nir Horesh, Michael R. Freund, Emanuela Silva-Alvarenga, Zoe Garoufalia, Rachel Gefen, Steven D. Wexner
Background This study aimed to determine predictors of overall survival (OS) after surgical treatment of stage I-III appendiceal adenocarcinoma and compare the outcomes of partial colectomy and hemicolectomy. Methods A retrospective analysis of the U.S. National Cancer Database (NCDB) including patients who underwent surgery for stage I-III appendiceal adenocarcinoma between 2005 and 2019 was conducted
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The use of thyroid isthmusectomy for management of well differentiated thyroid carcinoma - A systematic review and meta-analysis Surg. Oncol. (IF 2.3) Pub Date : 2023-12-27 Moon Usman, Peter Yao, Kathleen Luckett, Katerina Andreadis, Remil Thomas, Andy Hickner, Paul J. Christos, Andrew Tassler, David Kutler, William Kuhel, Victoria Banuchi
Objective With the growing global incidence of thyroid carcinomas, there is an increasing need for distinct guidelines for isthmus-confined carcinomas. Here, we performed the first systematic review on the topic to date, aiming to provide understanding to isthmusectomy as surgical management for well-differentiated thyroid carcinoma of the isthmus. Methods We conducted a systematic review following
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What is the diagnostic accuracy of fluorescence-guided surgery for margin assessment in appendicular bone and soft tissue tumors? - A systematic review of clinical studies Surg. Oncol. (IF 2.3) Pub Date : 2023-12-22 Erhan Okay, Marcos R. Gonzalez, Joseph O. Werenski, Alisha Sodhi, Korhan Ozkan, Marcus Brookes, Maniram Ragbir, Kenneth Rankin, Anand TN. Kumar, Santiago A. Lozano-Calderon
Background Fluorescence-guided surgery (FGS) is a novel technique to successfully assess surgical margins intraoperatively. Investigation and adoption of this technique in orthopaedic oncology remains limited. Methods The PRISMA guidelines were followed for this manuscript. Our study was registered on PROSPERO (380520). Studies describing the use of FGS for resection of bone and soft tissue sarcomas
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Advances and considerations in the use of immunotherapies for primary hepato-biliary malignancies Surg. Oncol. (IF 2.3) Pub Date : 2023-12-18 Leva Gorji, Zachary J. Brown, Timothy M. Pawlik
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) comprise the two most common primary liver malignancies. Curative treatment options often include hepatectomy or liver transplantation; however, many patients present with advanced disease that is not amenable to surgical management. In turn, many patients are treated with systemic or targeted therapy. The tumor microenvironment (TME) is a
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Predictors for quality of life, pain and functional outcomes after surgical treatment of metastatic disease in the spine Surg. Oncol. (IF 2.3) Pub Date : 2023-12-16 Sebastian G. Walter, Jan Hockmann, Maximilian Weber, Nikolaus Kernich, Peter Knöll, Kourosh Zarghooni
Background While predictors for postoperative survival in spine tumour patients have been identified, there is limited evidence for predictors of postoperative Quality of Life (QoL), pain and functional outcome. Methods One hundred and fifty-three consecutive patients, who had undergone surgery for symptomatic spinal metastases between June 2016 and April 2019, were interviewed preoperatively and during
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Evaluating health perceptions of soft-tissue sarcoma patients using the Wilson-Cleary Model to identify key targets for improving outcomes and quality of care Surg. Oncol. (IF 2.3) Pub Date : 2023-12-15 Nicole J. Andersen, Kedar K.B. Mate, Catherine Bergeron, Robert Turcotte, Annett Körner
Introduction Soft-tissue sarcoma (STS) is a rare cancer of the connective tissues requiring invasive treatment. Due to the complexity of treatment, STS patients experience more functional impairment and disability than other oncologic populations. Given that extant literature is unclear and exclusively focused on physical function, the objectives of this study were to use the Wilson-Cleary Model of
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The involvement of the hepatic artery is a risk factor for unresectability after neoadjuvant treatment in borderline pancreatic adenocarcinoma Surg. Oncol. (IF 2.3) Pub Date : 2023-12-11 Luis Secanella, Juli Busquets, Núria Peláez, María Sorribas, Berta Laquente, Sandra Ruiz-Osuna, Juan Fabregat
Introduction Borderline Resectable Pancreatic Ductal Adenocarcinoma (BR-PDAC) benefits from neoadjuvant treatment (NAT) with the intent of surgical salvage in the absence of disease progression during chemotherapy (CT) or chemoradiotherapy (CRT). Scarce literature exists about prognostic factors of resectability at the time of diagnosis or during neoadjuvant treatment, especially regarding vascular
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Pleomorphic dermal sarcoma of the scalp - A single-centre experience Surg. Oncol. (IF 2.3) Pub Date : 2023-12-05 Eyal Mor, Sarah Lonie, Catherine Mitchell, Michael Henderson, Angela Webb, David E. Gyorki, Hayden Snow
Background Pleomorphic dermal sarcoma (PDS) of the scalp is a rare tumour which is usually slow growing, but occasionally displays rapid growth and has a low rate of local recurrence. Surgical resection is the mainstay of treatment, with or without radiotherapy. The aim of this study is to describe the surgical approach and the additional benefit of radiotherapy to the treatment of these patients.
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Collaboration can be successful statewide Surg. Oncol. (IF 2.3) Pub Date : 2023-12-05 Nicholas Petrelli
Abstract not available
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The use of axillary ultrasound (AUS) to assess the nodal status after neoadjuvant chemotherapy (NACT) in primary breast cancer patients Surg. Oncol. (IF 2.3) Pub Date : 2023-11-24 Elena Leinert, Stefan Lukac, Lukas Schwentner, Antonia Coenen, Visnja Fink, Kristina Veselinovic, Davut Dayan, Wolfgang Janni, Thomas W.P. Friedl
Introduction Axillary Ultrasound (AUS) is standard for pre-therapeutic axillary staging in early breast cancer patients. 35–75 % of the breast cancer (BC) patients with positive axillary lymph nodes receiving neoadjuvant chemotherapy (NACT) convert to pathological node negative. For those patients, axillary surgery after NACT could be de-escalated, if an accurate prediction of the pathologic nodal
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Chest wall perforator flaps for partial breast reconstruction after conservative surgery: Prospective analysis of safety and reliability Surg. Oncol. (IF 2.3) Pub Date : 2023-11-23 Tiago Russell Pinto, Henrique Mora, Bárbara Peleteiro, André Magalhães, Diana Gonçalves, José Luís Fougo
Introduction Breast-conserving surgery associated with adjuvant radiotherapy is the state of the art in the surgical treatment of breast cancer. Oncoplastic surgery through dermo-adipose flaps based in perforating arteries (muscle sparing flaps) for partial reconstruction is increasingly used as a good option for avoiding musculocutaneous flaps. In this study we evaluate the outcomes of the use of
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A review of functional and surgical outcomes of gynaecological reconstruction in the context of pelvic exenteration Surg. Oncol. (IF 2.3) Pub Date : 2023-11-22 Matthew R. Fahy
Background Radical surgical excision may be the only curative option for patients with advanced pelvic malignancy, but concerns surrounding the functional outcomes and survivorship of patients undergoing exenterative surgery remain. This is especially important in the context of vulvovaginal resection, where patients are often younger and surgery can have a profoundly negative impact on quality of
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Femoral metastatic pathological fractures, impending and actual fractures – A patient survival study Surg. Oncol. (IF 2.3) Pub Date : 2023-11-03 Oded Hershkovich, Mojahed Sakhnini, Gal Barkay, Boaz Liberman, Alon Friedlander, Raphael Lotan
Introduction The skeleton is a common site for metastases. Prostate, breast, lung, renal and thyroid carcinomas account for 80 % of the original cancers, with the femur being the most affected long bone. With improved oncological treatments, prolonged patient survival leads to an increased prevalence of osseous metastases. This study examines the impact of preventive surgery for impending femoral pathological
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The accuracy of MRI in detecting pathological complete response following neoadjuvant chemotherapy in different breast cancer subtypes Surg. Oncol. (IF 2.3) Pub Date : 2023-10-31 Miroslava Kuzmova, Carolyn Cullinane, Claire Rutherford, Damian McCartan, Jane Rothwell, Denis Evoy, James Geraghty, Ruth S. Prichard
Background Pathological complete response (pCR) following neo-adjuvant chemotherapy (NACT) for breast cancer is associated with improved disease-free and overall survival in certain breast cancer subtypes. Magnetic Resonance Imaging (MRI) is increasingly used as standard to assess treatment response in patients receiving NACT. The aim of this study was to determine the clinical utility of MRI in accurately
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Analysis of the characteristics and outcomes of patients with pseudomyxoma peritonei of appendiceal origin treated with curative-intent surgery Surg. Oncol. (IF 2.3) Pub Date : 2023-11-05 Yasuyuki Kamada, Koya Hida, Yutaka Yonemura, Akiyoshi Nakakura, Toshiyuki Kitai, Akiyoshi Mizumoto, Shinya Yoshida, Yukinari Tokoro, Kazutaka Obama
Background There are no previous studies on pseudomyxoma peritonei regarding the details of surgical procedures included in cytoreductive surgery and quantitative evaluation for peritoneal metastases by region in the abdominal cavity. This study aimed to describe the characteristics and procedural details involved in cytoreductive surgery, and survival outcomes of patients with pseudomyxoma peritonei
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Comparison of histopathological margins after resection of oral squamous cell carcinoma using sharp dissection versus mono-polar electrocautery in T1 and T2 tumors Surg. Oncol. (IF 2.3) Pub Date : 2023-10-24 Katharina Thesesa Obermeier, Paris Liokatis, Wenko Smolka
The study aims to compare histopathological margins after resection of oral squamous cell carcinoma (OSCC) with different surgical techniques: conventional sharp resection (SR) with scalpel versus monopolar electrocautery (ME). Hence, the question arises whether thermal damage by performing monopolar electrocautery surgery will lead to close margins more frequently than by using scalpels. 152 patients
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Cost effectiveness of immune checkpoint inhibitors for treatment of Hepatocellular Carcinoma: A systematic review and Meta-analysis Surg. Oncol. (IF 2.3) Pub Date : 2023-10-24 Zaiba Shafik Dawood, Zachary J. Brown, Yutaka Endo, Erryk S. Katayama, Muhammad Musaab Munir, Laura Alaimo, Samantha M. Ruff, Henrique A. Lima, Selamawit Woldesenbet, Timothy M. Pawlik
Background Immune checkpoint inhibitors (ICIs) have recently been introduced into the treatment algorithm of patients with hepatocellular carcinoma (HCC). However, the cost effectiveness of ICIs compared with pre-existing therapies for HCC has not been assessed. We performed a meta-analysis to understand the incremental cost effectiveness of ICIs compared with sorafenib. Methods PubMed, Embase, Medline
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Gastric remnant cancer and long-term survival in Central Norway 2001 to 2016 – A population-based study Surg. Oncol. (IF 2.3) Pub Date : 2023-10-17 Ann Amelia Savage Ubøe, Christina Våge, Patricia Mjønes, Erling A. Bringeland, Reidar Fossmark
Introduction Gastric remnant cancer (GRC) has been defined as a distinct clinical entity and is reported to account for 1–8% of all gastric cancers. We aimed to characterize GRC patients and assess survival in a Western population. Methods Retrospective population-based cohort study including 1217 patients diagnosed with gastric adenocarcinoma in Central Norway 2001–2016. GRCs (n = 78) defined as adenocarcinomas
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New perspectives on cancer clinical research in the era of big data and machine learning Surg. Oncol. (IF 2.3) Pub Date : 2023-10-16 Shujun Li, Hang Yi, Qihao Leng, You Wu, Yousheng Mao
In the 21st century, the development of medical science has entered the era of big data, and machine learning has become an essential tool for mining medical big data. The establishment of the SEER database has provided a wealth of epidemiological data for cancer clinical research, and the number of studies based on SEER and machine learning has been growing in recent years. This article reviews recent
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Prognostic utility of preoperative and postoperative KRAS-mutated circulating tumor DNA (ctDNA) in resected pancreatic ductal adenocarcinoma: A systematic review and meta-analysis Surg. Oncol. (IF 2.3) Pub Date : 2023-10-10 Ali Alqahtani, Abdurahman Alloghbi, Philip Coffin, Chao Yin, Reetu Mukherji, Benjamin A. Weinberg
Background Pancreatic ductal adenocarcinoma (PDAC) is a challenging disease, with surgery being the only possible cure. However, despite surgery, the majority of patients experience recurrence. Recent evidence suggests that perioperative KRAS-mutated circulating tumor DNA (ctDNA) may have prognostic value. Therefore, we conducted a systematic review and meta-analysis to explore the prognostic significance
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Does compartmental resection really impact retroperitoneal soft tissue sarcomas? A retrospective analysis from a Single Referral Center Surg. Oncol. (IF 2.3) Pub Date : 2023-09-28 Dorian Yarih Garcia-Ortega, José Antonio Jiménez-Ortega, Ana Paulina Melendez-Fernandez, Alethia Álvarez-Cano, Claudia Haydee Sarai Caro-Sanchez, Ana Karina Vargas-Lara, Kuauhyama Luna-Ortiz
Background The treatment of choice for retroperitoneal soft tissue sarcomas (RPS) is surgical resection; the outcomes with more radical surgeries, notably compartmental resection, remains a subject of debate. Arguments against it, include the complexity of the technique and high morbidity. Materials and methods A retrospective analysis of cases treated in a single center from January 2010 to December
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A review of targeted therapy and immune checkpoint inhibitors for metastatic colorectal cancer Surg. Oncol. (IF 2.3) Pub Date : 2023-09-20 Samantha M. Ruff, Zachary J. Brown, Timothy M. Pawlik
Surgical resection is the cornerstone of treatment for metastatic colorectal cancer (CRC) and offers the best chance at long-term survival. Unfortunately, most patients do not present with resectable metastatic disease and, among patients who do undergo curative-intent resection, many will develop recurrence. In turn, patients require a multi-disciplinary treatment approach with a combination of chemotherapy
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Sublobar resection versus lobectomy for stage IA non–small-cell lung cancer: A systematic review and meta-analysis of randomized controlled trials Surg. Oncol. (IF 2.3) Pub Date : 2023-09-22 Patrick F. Meldola, Otávio A.S. Toth, Erick Schnorrenberger, Pablo G. Machado, Gabriel F.C. Chiarelli, José L.S. Kracik, Caio C. de Carvalho, Matheus de M. Lôbo, Jefferson L. Gross
Surgical resection is the first-line treatment for early-stage lung cancer, with lobectomy being the standard choice since the 1960s. Nevertheless, recent studies have shown controversies about whether sublobar resection or lobectomy is the optimal surgical approach today. In this sense, this meta-analysis aims to compare these techniques. PubMed, EMBASE, and Cochrane databases were searched for randomized
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Superior mesenteric vein/portal vein contact in preoperative imaging indicates biological malignancy in anatomically resectable pancreatic cancer Surg. Oncol. (IF 2.3) Pub Date : 2023-09-20 Yoshihiro Shirai, Shinji Onda, Yoshiaki Tanji, Ryoga Hamura, Michinori Matsumoto, Mitsuru Yanagaki, Masashi Tsunematsu, Tomohiko Taniai, Kochiro Haruki, Kenei Furukawa, Kyohei Abe, Taro Sakamoto, Takeshi Gocho, Tadashi Uwagawa, Toru Ikegami
Background Pancreatic cancer in contact with the superior mesenteric vein/portal vein is classified as resectable pancreatic cancer; however, the biological malignancy and treatment strategy have not been clarified. Methods Data of 186 patients who underwent pancreatectomy for pancreatic cancer were evaluated using a prospectively maintained database. The patients were classified as having resectable
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What is the optimal timing of surgery after short-course radiotherapy for rectal cancer? Surg. Oncol. (IF 2.3) Pub Date : 2023-09-20 Solomon-Miles Donnelly, James Wyatt, Simon G. Powell, Nia Jones, Kiran Altaf, Shakil Ahmed
Background Short-course neoadjuvant radiotherapy is a valuable tool in managing rectal cancers and has improved local recurrence rates. However, limited and conflicting data has resulted in variable usage and a lack of consensus on the optimal timing of surgery following short-course radiotherapy. This review aims to provide a contemporary summation of the available evidence regarding the optimal time
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Robotic liver resection of caudate lobe with 3-D rendering and intraoperative ICG-fluorescence for giant hemangioma Surg. Oncol. (IF 2.3) Pub Date : 2023-09-20 Gianluca Cassese, Roberto Montalti, Roberto Ivan Troisi
Abstract not available
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Elevated CA 19-9 is associated with worse survival in patients with resected ampullary adenocarcinoma Surg. Oncol. (IF 2.3) Pub Date : 2023-09-19 Artem Boyev, Laura R. Prakash, Yi-Ju Chiang, Timothy E. Newhook, Morgan L. Bruno, Elsa M. Arvide, Whitney L. Dewhurst, Michael P. Kim, Naruhiko Ikoma, Jeffrey E. Lee, Rebecca A. Snyder, Ching-Wei D. Tzeng, Matthew H.G. Katz, Jessica E. Maxwell
Background The prognostic utility of Carbohydrate Antigen 19-9 (CA 19-9) and Carcinoembryonic Antigen (CEA) in ampullary adenocarcinoma is unclear. We sought to evaluate the association between initial tumor marker levels and survival in patients with resected ampullary adenocarcinoma. Methods This was a single-institution, retrospective cohort study of consecutive patients who underwent pancreatoduodenectomy
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Total laparoscopic en bloc resection of intrahepatic cholangiocarcinoma invading the diaphragm Surg. Oncol. (IF 2.3) Pub Date : 2023-09-17 Sola Lee, YoungRok Choi, Ho-Seong Han
Abstract not available
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Radiomics and Machine Learning for prediction of two-year disease-specific mortality and KRAS mutation status in metastatic colorectal cancer Surg. Oncol. (IF 2.3) Pub Date : 2023-09-12 María Agustina Ricci Lara, Marco Iván Esposito, Martina Aineseder, Roy López Grove, Matías Alejandro Cerini, María Alicia Verzura, Daniel Roberto Luna, Sonia Elizabeth Benítez, Juan Carlos Spina
Purpose Colorectal cancer is usually accompanied by liver metastases. The prediction of patient evolution is essential for the choice of the appropriate therapy. The aim of this study is to develop and evaluate machine learning models to predict KRAS gene mutations and 2-year disease-specific mortality from medical images. Methods Clinical and follow-up information was collected from patients with
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Laparoscopic gastrectomy for remnant gastric cancer: A single-center retrospective study Surg. Oncol. (IF 2.3) Pub Date : 2023-09-10 Yusuke Umeki, Susumu Shibasaki, Kazumitsu Suzuki, Akiko Serizawa, Shingo Akimoto, Masaya Nakauchi, Tsuyoshi Tanaka, Kazuki Inaba, Ichiro Uyama, Koichi Suda
Background Laparoscopic gastrectomy (LG) for remnant gastric cancer (RGC) remains controversial because of its rarity and heterogeneity of clinical characteristics. Based on our experience, we posited that our established methodology in LG could be applied to the laparoscopic procedure for RGC surgery and introduced LG for RGC at our institution in 2004. Methods This study enrolled 46 patients who
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Prognostic nutritional index is a prognostic factor for patients with gastric cancer and esophagogastric junction cancer undergoing proximal gastrectomy with esophagogastrostomy by the double-flap technique: A secondary analysis of the rD-FLAP study Surg. Oncol. (IF 2.3) Pub Date : 2023-09-10 Yoshihiko Kakiuchi, Shinji Kuroda, Yasuhiro Choda, Shinya Otsuka, Satoshi Ueyama, Norimitsu Tanaka, Atsushi Muraoka, Shinji Hato, Yasuaki Kamikawa, Toshiyoshi Fujiwara
Purpose Although proximal gastrectomy (PG) is commonly used in patients with upper gastric cancer (GC) and esophagogastric junction (EGJ) cancer, long-term prognostic factors in these patients are poorly understood. The double-flap technique (DFT) is an esophagogastrostomy with anti-reflux mechanism after PG; we previously conducted a multicenter retrospective study (rD-FLAP) to evaluate the short-term
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Intravenous tranexamic acid decreases intraoperative transfusion requirements and does not increase incidence of symptomatic venous thromboembolic events in musculoskeletal sarcoma surgery Surg. Oncol. (IF 2.3) Pub Date : 2023-09-09 Matthew C. Hess, Nicholas A. Andrews, Brandon Crowley, Nikhi P. Singh, Cole Howie, Gerald McGwin, Herrick Siegel
Background and objectives Tranexamic acid (TXA) is poorly studied in patients with bone and musculoskeletal sarcoma due to perceived increased risk of venous thromboembolism (VTE). This study aims to assess the safety and efficacy of intravenous (IV) TXA for patients undergoing surgical resection of primary bone or soft-tissue sarcoma. Methods A retrospective, single center review of adult patients
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Magnetic resonance imaging accuracy in staging early and locally advanced rectal cancer Surg. Oncol. (IF 2.3) Pub Date : 2023-09-09 Kevin Arndt, Carolina Vigna, Sumedh Kaul, Anne Fabrizio, Thomas Cataldo, Martin Smith, Evangelos Messaris
Introduction Magnetic Resonance Imaging (MRI) is the standard pretreatment staging in patients with rectal cancer. Accurate tumor staging is paramount to determining the appropriate treatment course for patients diagnosed with rectal cancer. The current study aims to re-evaluate the accuracy of pre-operative MRI in staging of both early and locally advanced rectal cancer following completion of neoadjuvant
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Robotic partial resection of the caudate lobe for recurrent colorectal liver metastasis after open left hepatectomy and open rectosigmoidectomy Surg. Oncol. (IF 2.3) Pub Date : 2023-08-21 Marcel Autran Machado, Bruno H. Mattos, Murillo Lobo Filho, Fábio Makdissi
Abstract not available
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Racial and ethnic differences in colon cancer surgery type performed and delayed treatment among people 45 years old and older in the USA between 2007 and 2017: Mediating effect on survival Surg. Oncol. (IF 2.3) Pub Date : 2023-08-18 Pierre Fwelo, Oladipo Afolayan, Kenechukwu O.S. Nwosu, Akpevwe A. Ojaruega, Onyekachi Ahaiwe, Olajumoke A. Olateju, Ogochukwu Juliet Ezeigwe, Toluwani E. Adekunle, Ayrton Bangolo
Background This study examined the associations of socioeconomic status (SES), race/ethnicity, surgery type, and treatment delays with mortality among colon cancer patients. In addition, the study also quantifies the extent to which clinical and SES factors’ variations explain the racial/ethnic differences in overall survival. Patients and methods We studied 111,789 adult patients ≥45 years old who