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Para testicular cellular angiofibroma (AF)/angiomyofibroblastoma (AMF)-like tumor: A case report of a rare diagnosis in an elderly male Indian J. Cancer (IF 1.0) Pub Date : 2023-12-29 Vinayak N. Dave, Khushboo M. Sahetia, Santosh Menon
Cellular angiofibroma (AF)/Angiomyofibroblastoma (AMF)-like tumor is a rare benign mesenchymal neoplasm. It is very challenging to distinguish benign versus malignant mass radiologically. It is of paramount importance to distinguish Cellular Angiofibroma (CAF) microscopically from its differential diagnoses. A 64-year-old man presented with scrotal swelling. Pathological examination showed features
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CD47 expression in urothelial carcinoma and its correlation with histopathological findings Indian J. Cancer (IF 1.0) Pub Date : 2023-11-30 Ganime Çoban, Pelin Yıldız, Nurhan Şahin, Cevper Ersöz, Ali Toprak, Nurcan Ünver, Şahande Elagöz
Background: The incidence of bladder cancers (BCs) is increasing day by day in both males and females with increased smoking. New treatment protocols are required due to the long follow-up times and high recurrence rates. CD47 (integrin-associated protein) is a membrane receptor that is effective in normal and pathophysiological events such as apoptosis, proliferation, adhesion, and immunity. Phagocytosis
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Diagnostic value of WB-DWI versus 18F-FDG PET/CT for the detection of multiple myeloma Indian J. Cancer (IF 1.0) Pub Date : 2023-09-06 Bei Zhang, Li Zhang, Bingyang Bian, Fang Lin, Zining Zhu, Jiping Wang
Background: Whole-body diffusion-weighted imaging (WB-DWI) is commonly used for the detection of multiple myeloma (MM). Comparative data on the efficiency of WB-DWI compared with F-18 fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography (18F-FDG PET/CT) to detect MM is limited. Methods: This was a retrospective, single-center study of 22 patients with MM enrolled from January
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Tobacco use and its impact on survival in young patients with oral cancer Indian J. Cancer (IF 1.0) Pub Date : 2023-07-14 Narayana Subramaniam, Vijay Kumar Srinivasalu, Deepak Balasubramanian, Narender Kumar, Krishnakumar Thankappan, Subramania Iyer
Background: Tobacco is a major risk factor associaetd with developing oral factor. Recent studies have shown that the age of onset, especially in Asia, is reducing. This study was to determine if tobacco exposure correlated with prognosis in oral squamous cell carcinoms (OSCC) based on age at diagnosis. Methods: Six hundred and forty three patients of OSCC treated in our institution were divided
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Octreotide and postoperative pancreatic fistula after pancreaticoduodenectomy: What we know so far? A narrative review Indian J. Cancer (IF 1.0) Pub Date : 2023-07-14 Mandar Tilak, Mallika Tewari, H. S. Shukla
Postoperative pancreatic fistula (POPF) is the most feared complication following pancreatic resection. Octreotide, a synthetic somatostatin analog, has been widely used by pancreatic surgeons worldwide after pancreatic resections, often as per surgeon’s discretion, to prevent POPF especially in cases at high risk of developing POPF. We herein analyze the data available till date of the subject. A
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Choroid plexus papilloma in a mature cystic teratoma of ovary: A rare case report Indian J. Cancer (IF 1.0) Pub Date : 2023-07-14 Shikha Singh, Bharat U Patil, Nitin M. Gangane
Mature cystic teratoma of the ovary is the most common type of germ cell tumor. It constitutes approximately 20% of all ovarian neoplasms. As a rare occurrence, however, several types of benign and malignant tumours developing secondarily in dermoid cysts have been reported. Those of central nervous origin are almost exclusively gliomas of astrocytic, ependymal or oligodendroglial lineage. Choroid
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Nivolumab rechallenge after severe immune hepatitis in a metastatic renal cell cancer patient with hepatitis B and no detectable primary Indian J. Cancer (IF 1.0) Pub Date : 2023-04-19 Lutfiye Demir, Funda Canaz
Renal cell carcinoma (RCC) is an aggressive tumor with high metastatic potential and most of cases are determined incidentally on radiologic imaging. Metastatic RCC (mRCC) without a primary is very rare, and only a small number of cases have been reported in the literature. In recent years, immune checkpoint inhibitors have been used to treat mRCC, but they are associated with immune-related adverse
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Grossing and reporting of radical prostatectomy specimens: An evidence-based approach Indian J. Cancer (IF 1.0) Pub Date : 2023-04-17 B. Vishal Rao, Shailesh Soni, Bijal Kulkarni, MR Bindhu, Asawari Ambekar, Divya Midha, Seema Kaushal, Sachin Patil, Rakhi Jagdale, Sandhya Sundaram, Ramani Manoj Kumar, Sangeeta Desai, Santosh Menon
Radical prostatectomy (RP) constitutes the primary treatment option for patients with clinically localized, biopsy-proven prostate cancer that requires local treatment with curative intent. Accurate reporting of radical prostatectomy specimens is required to guide further risk stratification and management of patients. Hence, for the handling and reporting of RP specimens, a standardized protocol should
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Regulatory role of miRNAs on Wnt/β-catenin signaling in tumorigenesis of glioblastoma Indian J. Cancer (IF 1.0) Pub Date : 2023-03-21 Farzad Rahmani, Pedram Hashemian, Ayda Tadayyon Tabrizi, Zeynab Ghorbani, Aghigh Ziaeemehr, Sajede Alijannejad, Gordon A Ferns, Amir Avan, Soodabeh Shahidsales
Glioblastoma (GBM) is one of the most aggressive tumors in the brain with high mortality worldwide. Despite recent advances in therapeutic strategies, the survival rate remains low in patients with GBM. The pathogenesis of GBM is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Overactivation of the Wnt/β-catenin
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Association of hormonal and reproductive risk factors with breast cancer in Indian women: A systematic review of case–control studies Indian J. Cancer (IF 1.0) Pub Date : 2022-10-12 Ajeet P. Maurya, Swagata Brahmachari
The incidence of breast cancer in India has seen a rapid increase in recent years. Hormonal and reproductive risk factors for breast cancer have been affected by socioeconomic development. Studies on breast cancer risk factors in India are limited by the small sample size and specific geographical area. The current systematic review was carried out to assess the association of hormonal and reproductive
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What is the best method for long-term survival analysis? Indian J. Cancer (IF 1.0) Pub Date : 2022-10-01 G Nural Bekiroglu, Esin Avci, Emrah G Ozgur
In the Cox proportional hazards regression model, which is the most commonly used model in survival analysis, the effects of independent variables on survival may not be constant over time and proportionality cannot be achieved, especially when long-term follow-up is required. When this occurs, it would be better to use alternative methods that are more powerful for the evaluation of various effective
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Atypical MYC rearrangement pattern of 3’ deletion and 5’ amplification along with independent IGH rearrangement: A case study Indian J. Cancer (IF 1.0) Pub Date : 2022-10-01 Sandhya Kandoor, Ushang Kate, Prabal Deb, Sangita S. Mehta, B Vignesh Kanda Kumar, Anurita P. Pais
A spectrum of Cellular homolog of the v-myc oncogene (cMYC) alterations such as translocation, overexpression, mutation, and amplification plays an important role in lymphomagenesis, particularly in high-grade lymphomas, and are associated with prognostic significance. Accurate identification of cMYC gene alteration is important for diagnostic, prognostic, and therapeutic implications. With the application
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An alternative method for reconstructing anterior segmental mandibulectomy defects with a plate and pectoral major muscle flap Indian J. Cancer (IF 1.0) Pub Date : 2022-10-01 Jeyashanth Riju, Arun Paul, C Ajit, Amit Jiwan Tirkey
Background: Reconstruction of anterior segmental mandibulectomy still remains a challenge. Osteocutaneous free flap remains the ideal choice of reconstruction because it restores cosmesis and function. The use of other locoregional flaps compromises cosmesis and function. Here, we have introduced a unique technique of reconstruction with lingual cortex mandibular plate as an alternate choice for free
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Factors influencing women to participate in cervical cancer screening by providing menstrual pads: A population-based study from rural areas of Maharashtra state, India Indian J. Cancer (IF 1.0) Pub Date : 2022-10-01 Atul Budukh, Amita Maheshwari, Sonali Bagal, Arpit Singh, Kedar Deodhar, Nandkumar Panse, Vrushali Palyekar, Rajesh Dikshit, Rajendra Badwe
Background: India accounts for a quarter of the world cervical cancer burden. Cervical cancer is highly preventable. However, low level of participating women in screening is one of the major issues. The aim of this work was to study the factors that influence women to participate in cervical cancer screening by providing menstrual pads for human papillomavirus (HPV) testing. Methods: Menstrual clothes
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Lung and right atrial metastases from hepatoblastoma in children: A case series and literature review Indian J. Cancer (IF 1.0) Pub Date : 2022-08-02 Huimin Hu, Weiling Zhang, You Yi, Yanan Gao, Tian Zhi, Dongsheng Huang
Hepatoblastoma (HB) in children with both lung and right atrial metastases is an unusual situation. The therapy for these cases is challenging and the prognosis is not good. We present three children with HB showing both lung and right atrial metastases and who underwent surgery and received preoperative/postoperative adjuvant-combined chemotherapy to achieve complete remission. Therefore, HB with
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A meta-analysis of prognostic factors in patients with left-sided pancreatic cancer Indian J. Cancer (IF 1.0) Pub Date : 2022-07-01 Adeleh Hashemi Fard, Ramin Sadeghi, Seyed Ehsan Saffari, Seyed Majid Hashemi Fard, Mohsen Aliakbarian
Background: Patients with ductal adenocarcinoma of the body and tail of the pancreas usually remain asymptomatic until late in the course of the disease, and the survival of such patients depends on multiple factors, which may affect the therapeutic approach and patient survival. Hence, the aim of this study was to investigate such risk factors by pooling various available studies. Methods: A systematic
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Histopathological and immunohistochemical clues to the illusive diagnosis of follicular dendritic cell sarcoma: A clinicopathological masquerader Indian J. Cancer (IF 1.0) Pub Date : 2022-07-01 Ridhi Sood, Anurag Mehta
Follicular dendritic cell sarcoma is a rare histiocytic and dendritic neoplasm mainly involving the lymph nodes and selective extranodal sites. They are often misdiagnosed due to nonspecific clinical, radiological, and morphological findings in addition to their rarity. Four cases described below had variable age of presentation, site of involvement, size of the lesion, and histopathological features
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Transarterial chemoembolization in patients with hepatocellular carcinoma beyond Barcelona-Clinic Liver Cancer- B and portal vein tumor thrombosis: Experience from a tertiary care center Indian J. Cancer (IF 1.0) Pub Date : 2022-07-01 Santhosh Anand, Biju Pottakkat, Kalayarasan Raja, Sandip Chandrasekar, Santhosh Satheesh
Background: Transarterial chemoembolization (TACE) is the preferred treatment for patients with intermediate-stage hepatocellular carcinoma (HCC) without portal vein tumor thrombosis (PVTT). However, select patients with advanced HCC and with PVTT have shown improved survival with TACE. This study was undertaken to evaluate the outcome of TACE in patients with HCC beyond Barcelona-Clinic Liver Cancer-
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A comparison of two chemotherapy regimens in advanced, recurrent, or metastatic salivary gland carcinoma Indian J. Cancer (IF 1.0) Pub Date : 2022-06-29 Ahmad Ameri, Ainaz Sourati, Behnaz Behzadi, Mansour Lesan, Farzad Taghizadeh-Hesary
Background: The efficacy of chemotherapy in locally advanced, recurrent, and metastatic salivary gland carcinomas (LA-R/M SGCs) is still undefined. We aimed to compare the efficacy of two chemotherapy regimens in LA-R/M SGC. Materials and Methods: This prospective study compared paclitaxel (Taxol) plus carboplatin (TC) versus cyclophosphamide, doxorubicin, plus cisplatin (CAP) regimen in terms of
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Survival analysis and predictors of long-term outcomes following radical nephrectomy with inferior vena cava (IVC) thrombectomy in renal cell carcinoma Indian J. Cancer (IF 1.0) Pub Date : 2022-06-24 Harshit Garg, Brusabhanu Nayak, Ashish Kumar, Prabhjot Singh, Rishi Nayyar, Aashir Kaul, Amlesh Seth
Background: Renal cell carcinoma (RCC) presents with inferior vena cava (IVC) thrombus in 10%–30% cases and surgical management forms the mainstay of the treatment. The objective of this study is to assess the outcomes of the patients undergoing radical nephrectomy with IVC thrombectomy. Methods: A retrospective analysis of patients undergoing open radical nephrectomy with IVC thrombectomy between
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Can we dream of an integrated pain management app for cancer patients? Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 Pallavi Ahluwalia,Bhavna Gupta
The cancer burden continues to grow globally, exerting tremendous physical, emotional, and financial strain on individuals, families, communities, and health systems. The number of health-related mobile applications (apps) is increasing rapidly. We searched for pain apps specific for cancer patients on App Store for iOS devices and Google Play for Android devices. An integrated pain management app
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Langerhans cell sarcoma with BRAF-V600E mutation and hemophagocytosis: An autopsy report. Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 Manoj G Madakshira,Navneet Sharma,Pankaj Malhotra,Amanjit Bal
Langerhans cell sarcoma (LCS) is a rare high-grade neoplasm of langerhans cell phenotype having unambiguous malignant cytological features. We report such a rare case in a 20-year-old man who presented with dyspnea and high-grade fever. On evaluation, he had generalized lymphadenopathy, hepatosplenomegaly, and a large anterior mediastinal mass. Fine needle aspiration from the mediastinal mass and bone
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Unusual presentation of Langerhans cell sarcoma as bilateral submandibular gland swelling - A rare case report. Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 Pranita Mohanty,Nibedita Sahoo,Anasuya Lenka,Suvodip Bhattacharyya
Langerhans cell sarcoma (LCS) is a rare malignant tumor of Langerhans cells and uncommonly involves head and neck regions. Unlike Langerhans cell histiocytosis (LCH), it has an aggressive clinical course with malignant cytological features. Till now, a handful of cases have been reported and the common anatomical sites involved are skin, lymph node, and bone in loco - regional cases and lymph node
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Langerhans cell histiocytosis of thyroid: Case report with review of literature. Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 Subhash C Yadav,Munita Bal,Asawari Patil
Langerhans cell histiocytosis (LCH) is a rare monoclonal disease of antigen presenting cells. Involvement of thyroid gland by LCH is exceedingly rare. Herein, we present a case of LCH involving the thyroid in a 38-year-old woman. Our patient presented clinically as a case of primary thyroid neoplasm. Presence of elongated, epithelioid neoplastic cells with grooved nuclei along with presence of background
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Toolkit for delivering the 3Es and 6As tobacco interventions in dental care. Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 S Sujatha,Asha Iyengar,S Pruthvish,Radhaprashanth,Ravleen Nagi
Tobacco use is one of the major public health problems in India and also the single most important remediable public health problem. Tobacco cessation is the need of the hour. The dentists have a unique opportunity and professional obligation to be a positive influence in reducing the economic and social burden inflicted by tobacco use on dental and general health. However, dentists, in general, have
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Therapeutic approaches for relapsed/refractory adult acute lymphoblastic leukemia (ALL), a review on monoclonal antibodies and targeted therapies. Indian J. Cancer (IF 1.0) Pub Date : 2022-06-02 Maryam S Hosseini,Leila Jafari,Amir Yami,Ahmad Gharehbaghian
Acute lymphoblastic leukemia (ALL) is the malignant transformation of lymphoid progenitors that affects both children and adults. Although the outcome of pediatric patients has been improved dramatically, there are still many challenges in the treatment of adults. Patients with primary resistant or relapsed disease have the worst outcome and despite the administration of intensified multi-agents chemotherapies
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A review of clinical evidence to assess differences in efficacy and safety of luteinizing hormone-releasing hormone (LHRH) agonist (goserelin) and LHRH antagonist (degarelix). Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Ankur Bahl,Senthil Rajappa,Sudhir Rawal,Ganesh Bakshi,Vedang Murthy,Ketaki Patil
Luteinizing hormone-releasing hormone agonist (LHRH-A), goserelin, and antagonist, degarelix, are both indicated for the treatment of advanced prostate cancer (PCa); however, large comparative trials evaluating their efficacy and safety are lacking. In this review, we assessed the available evidence for both the drugs. Although degarelix achieves an early rapid decline in testosterone (T) and prostate-specific
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Gonadotropin-releasing hormone agonists in prostate cancer: A comparative review of efficacy and safety. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 T Raja,Rahul Sud,Sanjai Addla,Kalyan K Sarkar,P S Sridhar,Vikas Talreja,Minish Jain,Ketaki Patil
Androgen deprivation therapy (ADT) using gonadotropin-releasing hormone agonist (s) (GnRH-A) remains the backbone of advanced prostate cancer treatment. In this review, we assessed the efficacy, safety, and convenience of administration of various GnRH-A. All GnRH-A (goserelin, triptorelin, buserelin, histrelin, and leuprorelin) have comparable potential to suppress testosterone (T) levels (≤50 ng/dL
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Management of human epidermal growth factor receptor 2-negative metastatic breast cancer: Role of poly adenosine diphosphate (ADP-ribose) polymerase inhibitors. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Ashok Kumar Vaid,Chetan Deshmukh,Nitesh Rohatgi,Joydeep Ghosh
Human epidermal growth factor receptor 2 (HER2)-negative subset is the most heterogeneous group of metastatic breast cancers (MBCs) as it includes both hormone receptor (HR)-positive and HR-negative breast cancer (or TNBC), which have different therapies and treatment challenges. Though endocrine therapy (ET) remains the treatment backbone in HR-positive HER2-negative cases, about 40% of the patients
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A review on mechanisms of resistance to PARP inhibitors. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Chirag Desai,Anand Pathak,Sewanti Limaye,Vashishth Maniar,Archita Joshi
Standard therapy for advanced ovarian cancer (OC) consists of radical debulking cytoreductive surgery followed by adjuvant chemotherapy. An important risk factor for OC is genetic predisposition, with BRCA1 or BRCA2 mutations accounting for the majority of hereditary OC. Mutation in BRCA ultimately causes accumulation of genetic alterations because of the failure of cells to arrest and repair DNA damage
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Significance of emerging clinical oncology endpoints in support of overall survival. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Shekar Patil,Vijay Agarwal,H S Drupad
Despite a better understanding of the pathophysiology and development of newer therapeutic options, cancer remains an area with several unmet needs. Although overall survival (OS) remains a gold standard endpoint for all cancer therapies, it poses challenges such as the requirement of a long-term follow-up, a higher number of patients, and a higher financial burden. Therefore, surrogate endpoints such
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Evolving trends in lung cancer: Epidemiology, diagnosis, and management. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Ramakant Deshpand,Manish Chandra,Amit Rauthan
Lung cancer is one of the deadliest cancers globally and accounts for most of the cancer-related deaths in India. Comprehensive data on lung cancer in India are lacking. This review aimed to discuss the epidemiological trends of lung cancers and driver mutations as well as the recent advancements in molecular diagnostics and therapeutic options primarily in non-small cell lung cancer (NSCLC) in India
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Ideal sequencing in Stage IV epidermal growth factor receptor mutant Non-Small-Cell Lung Cancer. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Meenu Walia,Manish K Singhal,Mangesh S Kamle
Evidence from several studies has shown improved progression-free survival (PFS) with first- or second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) compared with chemotherapy for advanced NSCLC patients. But resistance to first or second-generation TKI therapies after 9 to 12 months of treatment initiation is a concern. Osimertinib is a third-generation, irreversible
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Role of immunotherapy in metastatic EGFRm NSCLC: Is it relevant? Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Boman Dhabhar,Tarini P Sahoo,J K Akshay
EGFR-TKIs have changed the landscape of metastatic NSCLC treatment with a significant improvement in survival of EGFRm patients compared to wild-type EGFR. Even with the newer third generation EGFR TKIs like, Osimertinib, which has proven efficacy against the resistance mutation of EGFRm T790M, progression eventually occurs. There are limited treatment options for patients with metastatic EGFRm NSCLC
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BRCA mutations: Implications of genetic testing in ovarian cancer. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Vineet Talwar,Amit Rauthan
Ovarian cancer (OC) is one of the most lethal gynecological cancers with a 5-year survival rate that ranges from 30% to 40%. Breast cancer genes (BRCA1 and BRCA2) play a key role in maintaining genomic stability. Mutations in BRCA1/2 genes lead to the accumulation of double-strand breaks, resulting in tumorigenesis. The risk of developing OC in women with BRCA1 and BRCA2 mutations is 39% and 11%, respectively
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Expert survey on management of prostate cancer in India: Real-world insights into practice patterns. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Ganesh Bakshi,Hemant Tongaonkar,Sanjai Addla,Santosh Menon,Aditya Pradhan,Abhay Kumar,Abhijit Bapat,Adwaita Gore,Amit Joshi,Anand Raja,Anil Bradoo,Anita Ramesh,Anup Kumar,Archi Agrawal,Asawari Ambekar,Ashish Joshi,Ashish Singh,Bhupendra Pal Singh,Deepak Dabkara,Dhiraj Khadakban,Gagan Gautam,Gagan Prakash,Harvinder Singh Pahwa,Hemant Kumar Goel,Jagdeesh Kulkarni,Jeeban Jyoti Mishra,Kaushal Patel,Mahendra
To gain insights on the diverse practice patterns and treatment pathways for prostate cancer (PC) in India, the Urological Cancer Foundation convened the first Indian survey to discuss all aspects of PC, with the objective of guiding clinicians on optimizing management in PC. A modified Delphi method was used, wherein a multidisciplinary panel of oncologists treating PC across India developed a questionnaire
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Relevance of multi-disciplinary team approach in diagnosis and management of Stage III NSCLC. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Ullas Batra,Anusheel Munshi,Vedant Kabra,Gagandeep Momi
Lung cancer is reported as the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) constitutes 80%-85% of all lung cancers. Diagnosis of NSCLC is a complex multistep process. The prognosis of NSCLC is poor as most of the patients are presented at the metastatic stage. The management of these patients needs the expertise of different specialists. A multidisciplinary
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CONCORDANCE: A real-world evidence study to evaluate the concordance of detecting epidermal growth factor receptor (EGFR) mutation by circulating tumor DNA* versus tissue biopsy in patients with metastatic non-small cell lung cancer. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Kumar Prabhash,Bivas Biswas,Sachin Khurana,Ullas Batra,Ghanashyam Biswas,Suresh Hariram Advani,Prabrajya N Mohapatra,Senthil Rajappa,Ajay Sharma,Shekhar Patil,Palanki Satya Dattatreya,Rakesh Roy,Sachin Almel,Gautam Goyal,Narayanankutty Warrier
Background Molecular tissue testing in non-small cell lung cancer (NSCLC) is done for the assessment of epidermal growth factor receptor (EGFR) mutation. EGFR mutation status is the basis for deciding the targeted treatment option for patients with metastatic NSCLC. The nonavailability of tissue samples and contraindications for biopsy pose a significant challenge. Hence, circulating tumor DNA (ctDNA)
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Safety of osimertinib in adult patients with metastatic epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer: Results from a Phase IV study in India. Indian J. Cancer (IF 1.0) Pub Date : 2022-03-01 Prabhat S Malik,Vanita Noronha,Deepak Dabkara,Vamshi K Maddu,Senthil Rajappa,Sewanti Limaye,Ullas Batra
Background A Phase IV, single-arm study was conducted to assess the safety of osimertinib in Indian patients with epidermal growth factor receptor (EGFR) T790M mutation-positive stage IV non-small cell lung cancer (NSCLC). Methods Enrolled patients received 80 mg osimertinib for six cycles or until disease progression or unacceptable toxicity or withdrawal. Primary safety variables included treatment-emergent
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Primary malignant melanoma of the cerebellopontine angle: A rare entity. Indian J. Cancer (IF 1.0) Pub Date : 2022-01-04 Siddhi Gaurish Sinai Khandeparkar,Lokesh Ashok Fegade,Bageshri P Gogate,Nikhil Talathi
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Kaposiform hemangioendothelioma of leg: An unusual presentation. Indian J. Cancer (IF 1.0) Pub Date : 2022-01-04 Adarsh W Barwad,Ekta Dhamija,Venkatesan S Kumar,Sameer Rastogi,Asit R Mridha
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Infrarenal extensive tumor thrombus in renal cell carcinoma: A rare presentation. Indian J. Cancer (IF 1.0) Pub Date : 2022-01-04 Satish K Ranjan,Rudra P Ghoarai,Sunil Kumar
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Older patients with cancer require and deserve more! Indian J. Cancer (IF 1.0) Pub Date : 2022-01-04 Anant Ramaswamy,Vanita Noronha
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Artificial intelligence in cancer diagnostics and therapy: current perspectives Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Anusree Majumder, Debraj Sen
Artificial intelligence (AI) has found its way into every sphere of human life including the field of medicine. Detection of cancer might be AI's most altruistic and convoluted challenge to date in the field of medicine. Embedding AI into various aspects of cancer diagnostics would be of immense use in dealing with the tedious, repetitive, time-consuming job of lesion detection, remove opportunities
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Gross reporting of adult kidney tumor specimens: A comprehensive evidence-based review Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Divya Midha, Santosh Menon, S Josephine, Ramani M Kumar, Seema Kaushal, Sanjay A Pai, Asawari Ambekar, Vishal Rao, MR Bindhu, Sachin Patil, Rakhi Jagdale, Shailesh Soni, Bijal Kulkarni, Sangeeta Desai, Sandhya Sundaram
Renal tumors comprise a wide spectrum of benign and malignant tumors. The important prognostic factors in renal cell carcinoma include pathological stage, tumor grade, morphological type, sarcomatoid/rhabdoid differentiation, and tumor necrosis. Therefore, the pathologist needs to be fully aware of how to gross nephrectomy specimens to be able to accurately provide the above prognostic information
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Pancreatic exocrine insufficiency occurs in most patients following pancreaticoduodenectomy Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Thogari K Kumar, Mallika Tewari, SK Shukla, SP Mishra
Background: Pancreatic exocrine insufficiency (PEI) is a well-defined complication of malignant diseases and pancreatic resection; however, study results of PEI are less consistent. Assessment of PEI by estimation of fecal elastase (FE)-1 in stool by enzyme-linked immunosorbent essay (ELISA) is a relatively inexpensive, noninvasive, and simple test. This study assessed exocrine function of pancreas
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Predictors of chemotherapy tolerance and survival benefit in a geriatric patient population with advanced solid tumors Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Yan Xu, Li Ding, Yong-Qiang Zhang
Background: It is challenging to identify robust elderly patients suitable for systemic chemotherapy. The goal of this study was to ascertain clinical characteristics that may best predict the most benefit of systemic chemotherapy for geriatric patients (aged ≥80 years) with advanced solid tumors. Methods: A retrospective cohort study was conducted of advanced solid tumors patients treated with systemic
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ALK-positive anaplastic large T-cell lymphoma presenting primarily as a sinonasal mass with pseudoproptosis: A case report Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Siddhi G Sinai Khandeparkar, Priya Bagale, Smita Pathade, Bageshri Gogate, Shivani Battin
We report a case of anaplastic lymphoma kinase-positive anaplastic large T-cell lymphoma (ALK+ALCL) presenting primarily as a sinonasal mass with pseudoproptosis in an 11-year-old boy. The diagnosis was based on histopathological and immunohistochemical (IHC) evaluation, which is indispensable for determining tumor type. On the basis of clinicoradiological findings, provisional differential diagnoses
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NGS-based profiling of key cancer genes in Indian triple-negative breast cancer patients reinforces molecular heterogeneity of the disease Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Nandini A Sahasrabuddhe, Aruna Korlimarla, Madhura Kulkarni, Vinay Kusuma, Jyothi S Prabhu, Santosh Dixit, Chetan Deshmukh, TS Sridhar, Aditya Phatak, Chaitanyananda Koppiker
Triple-negative breast cancers (TNBC) are one of the most aggressive forms of breast cancers. With poor patient outcomes, it presents a great burden on the healthcare systems. There have been some efforts to explore the genomic changes that occur in TNBCs. However, there is not enough data on Indian TNBCs. We sought to understand the mutational landscape of key cancer-associated genes in Indian TNBC
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Necrotizing fasciitis of the lower extremity secondary to a perforated rectosigmoid tumor Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Suleyman Utku Celik, Rahman Senocak
Necrotizing fasciitis (NF), which is a rare but life-threatening soft tissue infection, can present as a complication of colorectal diseases. The development of NF of the lower extremity secondary to a perforated colorectal tumor has been reported in only a few patients. We present a case of a 68-year-old woman, in which necrotizing soft tissue infection of the left lower extremity was the presenting
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Acquired cystic disease-associated renal cell carcinoma: A clinicopathologic study of eight tumors with clinical follow-up Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Magdalena Chrabańska, Jakub Ryszawy, Bogna Drozdzowska
Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is the major RCC subtype in patients with end-stage renal disease, specifically those with ACD on dialysis. Three patients with a total of eight tumors have been selected. The aim of this study was to analyze clinicopathologic, immunohistochemical, and prognostic features of eight ACD-RCCs. Three patients with end-stage renal disease
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Lessons from narrative medicine: Cancer care will improve with narrative oncologyLessons from narrative medicine: Cancer care will improve with narrative oncology Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Bidhu Kalyan Mohanti
Narrative medicine (NM) is a new discipline in healthcare that helps the patients and physicians to tell and listen to the accounts of disease, illness, and suffering. In the last 20 years, NM has moved into the realms of biomedical education, research, and training. The complexity of cancer management can gain from the medical humanism of NM. A new model of cancer care called narrative oncology (NO)
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Retrospective analysis of 34 febrile neutropenia episodes - therapeutic implication of multiplex polymerase chain reaction in infection diagnosis Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Sachin Jadhav, Mahesh Rajashekaraiah, Dipanjan Chakraborty, N Bharath, Safeer Ulla Sharieff, G Vignesh, Keerthi Gandhamaneni, Bashwanth Pasupuleti, Priya Thomas, Jayantha Balawardhana
Background: Hemato-oncologic patients on chemotherapy or undergoing bone marrow transplantation are susceptible to infections due to neutropenia. Incidences of febrile neutropenia (FN) in these patients are common, contributing to high mortality and morbidity. Lack of diagnosis of pathogens responsible for infections in these patients is a major healthcare challenge. Newer molecular diagnostics are
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Acute neurological complications during acute lymphoblastic leukemia therapy: A single-center experience over 10 years Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Emine A Rahiman, Aruna Rajendran, Naveen Sankhyan, Paramjeet Singh, Jayashree Muralidharan, Deepak Bansal, Amita Trehan
Background: Acute neurological complications occur in 3.6-11% of children treated for acute lymphoblastic leukemia (ALL). This analysis aimed to evaluate the profile of acute neuro-toxicity and its etiology in children with ALL. Methods: A retrospective case analysis of central nervous system events in children treated for ALL at our center was performed. Details of events were retrieved from the case
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Survival impact of optimal treatment for elderly patients with colorectal cancer: A real world study Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Nadiye Akdeniz, Mehmet Küçüköner, Muhammet A Kaplan, Zuhat Urakçı, Yasin Sezgin, Oğur Karhan, Abdurrahman Işıkdoğan
Background: In this real-life practice study, we aimed to find whether elderly colorectal cancer (CRC) patients in our center were treated optimally and also if this has an effect on overall survival (OS) or not. Methods: We have retrospectively screened 150 CRC patients older than 65 years, diagnosed in our institution between 2010 and 2018. As study variables, patient characteristics, tumor location
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Content analysis of patient material resources on the internet for oral cancer—An exploratory study Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Shreya Bhatia, Gururaghavendran Rajesh, Almas Binnal, S Shreya Sarkar, Chirag Suhane
Background: Oral cancer is one of the leading causes of mortality in the world over and is a major public health problem. There are numerous resources on the internet which provide information related to oral cancer. However, they may not be optimal and standardized. The present study was conducted to assess the quality, readability, and content of the online resources for oral cancer. Methods: The
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A survey of the practice of stereotactic body radiotherapy for hepatocellular and pancreatic malignancies in India Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Shirley Lewis, Supriya Chopra, Roshni Singh, Reena Engineer
Background: Stereotactic body radiotherapy (SBRT) is increasingly being performed for hepatocellular cancer and liver metastases. The purpose of this study was to review the practice of SBRT for hepatocellular, pancreatic cancer and liver metastases in India. Methods: A survey comprising of 25 questions was designed and served to radiation oncology professionals at two major conferences. The survey
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PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Hayriye Sahinli, Nalan Akyürek, Mukaddes Yılmaz, Olcay Kandemir, Ayşe Ocak Duran, Sezer Kulaçoğlu, Gökhan Uçar, Elif Acar, Ahmet Özet, Mahmut Gümüş, Ö Berna Ç. Öksüzoğlu, Nuriye Y Özdemir
Background: Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients. Methods: Seventy patients diagnosed with non-metastatic NPC were included in the study. PD-L1 expression on immune
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Factors affecting pathological response and survival following neoadjuvant chemoradiotherapy in rectal cancer patients Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Meryem Aktan, Berrin Benli Yavuz, Gul Kanyilmaz, Pembe Oltulu
Background: Despite all advanced treatment methods for rectal cancer, not all patients can provide an adequate response, and hence, possible prognostic factors must be evaluated. The aim of this study was to evaluate the relationship between systemic inflammatory markers and pathological response, overall survival (OS) and disease-free survival (DFS) in patients treated with neoadjuvant chemoradiotherapy
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Pilot testing and vernacular translation of a questionnaire for assessment of satisfaction in patients on radiotherapy in India Indian J. Cancer (IF 1.0) Pub Date : 2021-10-01 Jifmi Jose Manjali, Tejpal Gupta, Sarbani Ghosh-Laskar, Rakesh Jalali, Rajiv Sarin, Jai Prakash Agarwal
Background: Patient satisfaction has emerged as a yardstick to measure success of healthcare ecosystems. OUTPATSAT-35RT is a questionnaire to assess patient satisfaction on outpatient radiotherapy (RT). However, it is yet to be translated and/or validated in any of the common Indian languages. Methods: English version of OUTPATSAT-35RT was pilot tested in 20 patients with working knowledge of English