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Trends and Hotspots in Global Radiomics Research: A Bibliometric Analysis Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-03-11 Minghui Zhang, Yan Wang, Mutian Lv, Li Sang, Xuemei Wang, Zijun Yu, Ziyi Yang, Zhongqing Wang, Liang Sang
Objectives: The purpose of this research is to summarize the structure of radiomics-based knowledge and to explore potential trends and priorities by using bibliometric analysis. Methods: Select radiomics-related publications from 2012 to October 2022 from the Science Core Collection Web site. Use VOSviewer (version 1.6.18), CiteSpace (version 6.1.3), Tableau (version 2022), Microsoft Excel and Rstudio's
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Patient Cranial Angle and Intrafractional Stability in CyberKnife Robotic Radiosurgery: A Retrospective Analysis Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-03-10 Chen-Lin Kang, Ya-Yu Huang, Yi-Ren Chen, Shu-Huei Tsai, Chun-Chieh Huang, Yu-Jie Huang
Purpose: The aim of this study was to investigate whether variations in cranial angles and treatment accuracy during CyberKnife robotic radiosurgery necessitate adjustment of the margins of the planning target volume. Patients and Methods: Data from 66 patients receiving CyberKnife treatment for brain tumors were retrospectively analyzed. Patients were immobilized using a thermoplastic mask and headrest
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The Effect of Dose Enhancement in Tumor With Silver Nanoparticles on Surrounding Healthy Tissues: A Monte Carlo Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-03-07 Mustafa ÇAĞLAR, Dursun EŞİTMEZ, Mehmet Sıddık CEBE
Objectives: Cancer-related death rates account for approximately one-third of all deaths, and this rate is increasing remarkably every year. In this study, we examined the dose enhancement factor (DEF) in the tumor and surrounding tissues by adding different concentrations of silver nanoparticles (AgNPs) to the brain tumor using the Monte Carlo (MC) technique. Methods: This study used MCNP6.2 simulation
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HCC-Check: A Novel Diagnostic Tool for Early Detection of Hepatocellular Carcinoma Based on Cytokeratin-1 and Epithelial Membrane Antigen: A Cross-Sectional Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-03-04 Kareem A. Attallah, Mohamed S. Albannan, Khaled Farid, Sherine M. Rizk, Nevine Fathy
Background: Hepatocellular carcinoma is frequently diagnosed in advanced stages, leading to a poorer prognosis. Therefore, early diagnosis and identification of biomarkers may significantly improve outcomes. Methods: This cross-sectional study enrolled 486 participants distributed among 3 groups: F1 to F3 = 184, F4 = 183, and hepatocellular carcinoma = 119. Liver fibrosis staging was performed using
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Elevated INHBA Promotes Tumor Progression of Cervical Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-29 Zhenghong Wu, Jina Chen, Lina Yang, Ke Sun, Qianqian Jiang, Fuyun Dong, Wei Lu, Rujun Chen, Yaping Chen
Objectives: This study aimed to explore the role of inhibin subunit beta A (INHBA) in the progression of cervical cancer (CCa) and investigate its potential as a therapeutic target. Specifically, the objectives were to assess the expression levels of INHBA in CCa, examine its correlation with patient survival, and elucidate its impact on CCa cell proliferation, cell cycle regulation, migration, invasion
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Decanoylcarnitine Inhibits Triple-Negative Breast Cancer Progression via Mmp9 in an Intermittent Fasting Obesity Mouse Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-27 Yifan Tang, Shuai Chen, Saijun Wang, Ke Xu, Kun Zhang, Dongmei Wang, Ninghan Feng
Purpose: Treatment of triple-negative breast cancer (TNBC) remains challenging. Intermittent fasting (IF) has emerged as a promising approach to improve metabolic health of various metabolic disorders. Clinical studies indicate IF is essential for TNBC progression. However, the molecular mechanisms underlying metabolic remodeling in regulating IF and TNBC progression are still unclear. Methods: In
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The Value of Dual-Energy Computed Tomography-Based Radiomics in the Evaluation of Interstitial Fibers of Clear Cell Renal Carcinoma Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-26 Xue Bing, Ning Wang, Yuhan Li, Haitao Sun, Jian Yao, Ruobing Li, Zhongyuan Li, Aimei Ouyang
ObjectiveWe investigated the potential of dual-energy computed tomography (DECT) radiomics in assessing cancer-associated fibroblasts in clear cell renal carcinoma (ccRCC).MethodsA retrospective analysis was conducted on 132 patients with ccRCC. The arterial and venous phase iodine-based material decomposition images (IMDIs), virtual non-contrast images, 70 keV, 100 keV, and 150 keV virtual monoenergetic
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Targeting Receptor Tyrosine Kinases as a Novel Strategy for the Treatment of Triple-Negative Breast Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-23 Sara K. Jaradat, Nehad M. Ayoub, Ahmed H. Al Sharie, Julia M. Aldaod
Triple-negative breast cancer (TNBC) comprises a group of aggressive and heterogeneous breast carcinoma. Chemotherapy is the mainstay for the treatment of triple-negative tumors. Nevertheless, the success of chemotherapeutic treatments is limited by their toxicity and development of acquired resistance leading to therapeutic failure and tumor relapse. Hence, there is an urgent need to explore novel
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Proton Therapy in Breast Cancer: A Review of Potential Approaches for Patient Selection Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-23 Xiao-Yu Wu, Mei Chen, Lu Cao, Min Li, Jia-Yi Chen
Proton radiotherapy may be a compelling technical option for the treatment of breast cancer due to its unique physical property known as the “Bragg peak.” This feature offers distinct advantages, promising superior dose conformity within the tumor area and reduced radiation exposure to surrounding healthy tissues, enhancing the potential for better treatment outcomes. However, proton therapy is accompanied
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Computer Vision and Machine-Learning Techniques for Automatic 3D Virtual Images Overlapping During Augmented Reality Guided Robotic Partial Nephrectomy Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-20 Daniele Amparore, Michele Sica, Paolo Verri, Federico Piramide, Enrico Checcucci, Sabrina De Cillis, Alberto Piana, Davide Campobasso, Mariano Burgio, Edoardo Cisero, Giovanni Busacca, Michele Di Dio, Pietro Piazzolla, Cristian Fiori, Francesco Porpiglia
ObjectivesThe research's purpose is to develop a software that automatically integrates and overlay 3D virtual models of kidneys harboring renal masses into the Da Vinci robotic console, assisting surgeon during the intervention.IntroductionPrecision medicine, especially in the field of minimally-invasive partial nephrectomy, aims to use 3D virtual models as a guidance for augmented reality robotic
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Comparison of Treatment Outcomes Between Thoracoscopic Surgery and Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-20 Qin Tian, Xinxin Zhao, Cong Zhang, Nannan Tian, Hongchun Bian
Objective: To compare the risk of death, tumor recurrence, metastasis, and disease progression in early-stage non-small cell lung cancer (NSCLC) patients treated with thoracoscopic surgery and stereotactic body radiotherapy (SBRT). Methods: Patients who underwent radical surgery and SBRT for NSCLC between April 2010 and November 2021 were retrospectively analyzed. Continuous and categorical variables
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Evaluation of a New Method for CyberKnife Treatment for Central Lung and Mediastinal Tumors by Tracheobronchial Tracking Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-20 Toshihiro Suzuki, Masahide Saito, Hiroshi Takahashi, Hidekazu Suzuki, Koji Makino, Koji Ueda, Koji Mochizuki, Zennosuke Mochizuki, Hikaru Nemoto, Naoki Sano, Hiroshi Onishi
BackgroundCyberKnife treatment for central lung tumors and mediastinal tumors can be difficult to perform with marker less.PurposeWe aimed to evaluate a novel tracheobronchial-based method (ie, tracheobronchial tracking) for the purpose of minimally invasive CyberKnife treatment for central lung and mediastinal tumors.MethodsFive verification plans were created using an in-house phantom. Each plan
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A Novel Necroptosis-Related Signature Can Predict Prognosis and Chemotherapy Sensitivity in Multiple Myeloma Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-16 Jun-Yao Jiang, Fang-Yi Yao, Jing Liu, Xin-Lu Wang, Bo Huang, Fang-Min Zhong, Xiao-Zhong Wang
BackgroundNecroptosis is an inflammatory cell death mode, and its association with multiple myeloma (MM) remains unclear.MethodsThis prospective study first analyzed the association between necroptosis-related signature as well as prognosis and chemotherapy sensitivity in MM using the necroptosis score. Consensus clustering was used to identify necroptosis-related molecular clusters. Least absolute
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Extracellular Vesicles Obtained From Lung Adenocarcinoma Cells Cultured Under Intermittent Hypoxia Induce M2 Macrophage Polarization via miR-20a-5p Delivery Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-08 Yuanling Liu, Minzhen Lu, Feng Liu, Gang Xu, Congrui Feng, Yuluo Chen, Danyan Cai, Huake Sun, Yanjun Zeng, Jian Xie, Wei Ma, Xinglin Gao
Introduction: Intermittent hypoxia (IH), an important feature of obstructive sleep apnea, enhances the function of lung cancer cell-derived extracellular vesicles (EVs) to exacerbate the immunosuppressive properties of macrophages. Herein, we investigated the effects of EVs obtained from lung adenocarcinoma cells cultured under IH on macrophage polarization. Methods: The M1-type and M2-type tumor-associated
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Multileaf Collimator Modeling and Commissioning for Complex Radiation Treatment Plans Using 2-Dimensional (2D) Diode Array MapCHECK2 Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-05 Jian Guo, Meng Zhu, Weijin Zeng, He Wang, Songbing Qin, Zhibin Li, Yu Tang, Binbin Ying, Jiugao Sang, Ming Ji, Kuo Meng, Zhouguang Hui, Jianyang Wang, Juying Zhou, Yin Zhou, Jian Huan
Purpose: This study aims to develop a data-collecting package ExpressMLC and investigate the applicability of MapCHECK2 for multileaf collimator (MLC) modeling and commissioning for complex radiation treatment plans. Materials and methods: The MLC model incorporates realistic parameters to account for sophisticated MLC features. A set of 8 single-beam plans, denoted by ExpressMLC, is created for the
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HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-02 Sun Yi Park, Ji-Ho Park, Jung Wook Yang, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Taejin Park, Miyeong Park, Young-Joon Lee, Sang-Ho Jeong
Introduction: The purpose of this study was to compare the transcriptomes of poorly cohesive carcinoma (PCC; diffuse-type) and well-differentiated tubular adenocarcinoma (WD; intestinal-type) using gastric cancer (GC) tissues and cell lines and to evaluate the prognostic role of HIV-1 Tat Interactive Protein 2 (HTATIP2). Materials and Methods: We performed next-generation sequencing with 8 GC surgical
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Analysis of Individualized Silicone Rubber Bolus Using Fan Beam Computed Tomography in Postmastectomy Radiotherapy: A Dosimetric Evaluation and Skin Acute Radiation Dermatitis Survey Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-02-01 Xue-mei Chen, Chen-di Xu, Li-ping Zeng, Xiao-tong Huang, Ao-qiang Chen, Lu Liu, Liu-wen Lin, Le-cheng Jia, Hua Li, Xiao-bo Jiang
Objective: To investigate the dosimetric effects of using individualized silicone rubber (SR) bolus on the target area and organs at risk (OARs) during postmastectomy radiotherapy (PMRT), as well as evaluate skin acute radiation dermatitis (ARD). Methods: A retrospective study was performed on 30 patients with breast cancer. Each patient was prepared with an individualized SR bolus of 3 mm thickness
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Rad51 and Systemic Inflammatory Indicators as Novel Prognostic Markers in Esophageal Squamous Cell Carcinoma Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-23 Ning Wu, Yang Song, Yongjun Zhu, Liewen Pang, Zhiming Chen, Xiaofeng Chen
BackgroundRAD51 is a central protein involved in homologous recombination, which has been linked to cancer development and progression. systemic inflammatory indicator markers such as neutrophil-to-lymphocyte ratio and lymphocyte-to-monocyte ratio have also been implicated in cancer. However, the relationship between Rad51 and these inflammatory markers in esophageal cancer patients undergoing esophagectomy
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Comparison of Efficacy and Safety of Second-Line Treatment Options for Advanced Small-Cell Lung Cancer: A Retrospective Analysis Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-23 Luqing Zhao, Zhiting Zhao, Xiaoqi Yan, Xiao Hu, Jifeng Feng, Shaorong Yu
ObjectiveAs monotherapy such as topotecan has reached a plateau of effectiveness, new second-line treatments based on experience have been used in clinical application. This study compared the efficacy and safety of different second-line treatments for advanced small-cell lung cancer (SCLC).MethodsA total of 380 patients with advanced SCLC were screened selectively in the retrospective study. Adverse
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Assessing the Impact of a 1.5 T Transverse Magnetic Field in Radiotherapy for Esophageal Cancer Patients Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-23 Yukun Li, Baosheng Li, Jian Zhu, Yong Yin, Zhenjiang Li
Purpose: Magnetic resonance (MR)-guided radiotherapy enables visualization of static anatomy, capturing tumor motion, and extracting quantitative image features for treatment verification and outcome monitoring. However, magnetic fields in online MR imaging (MRI) require efforts to ensure accurate dose measurements. This study aimed to assess the dosimetric impact of a 1.5 T magnetic field in esophageal
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Combination of Palbociclib and Endocrine Therapy in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer With or Without Brain Metastases Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-18 Qiuyi Zhang, Xiaofeng Lan, Jiayi Huang, Xiaofeng Xie, Liping Chen, Lin Song, Xue Bai, Xuelian Chen, Haiman Jing, Caiwen Du
ObjectiveThis real-world study aimed to investigate the efficacy and safety of palbociclib plus endocrine therapy in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer in the real world in a Chinese population.MethodsThe clinical data of consecutively enrolled patients from the Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen
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Prediction Model of Ocular Metastases in Gastric Adenocarcinoma: Machine Learning-Based Development and Interpretation Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-18 Jie Zou, Yan-Kun Shen, Shi-Nan Wu, Hong Wei, Qing-Jian Li, San Hua Xu, Qian Ling, Min Kang, Zhao-Lin Liu, Hui Huang, Xu Chen, Yi-Xin Wang, Xu-Lin Liao, Gang Tan, Yi Shao
Background: Although gastric adenocarcinoma (GA) related ocular metastasis (OM) is rare, its occurrence indicates a more severe disease. We aimed to utilize machine learning (ML) to analyze the risk factors of GA-related OM and predict its risks. Methods: This is a retrospective cohort study. The clinical data of 3532 GA patients were collected and randomly classified into training and validation sets
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Deciphering the Tumor Microenvironment of Colorectal Cancer and Guiding Clinical Treatment With Patient-Derived Organoid Technology: Progress and Challenges Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-16 Jingwei Li, Jianhua Liu, Wuzheng Xia, Hongwei Yang, Weihong Sha, Hao Chen
Colorectal cancer (CRC) is one of the most prevalent malignant tumors of the digestive tract worldwide. Despite notable advancements in CRC treatment, there is an urgent requirement for preclinical model systems capable of accurately predicting drug efficacy in CRC patients, to identify more effective therapeutic options. In recent years, substantial strides have been made in the field of organoid
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Research Progress on Structure-Activity Relationship of 1,8-Naphthalimide DNA Chimeras Against Tumor Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-16 Hai-yang Zhang, Li-li Han, Hong-yi Wu, Xiang-xiang Xu, Meng-bin Yu, Gao-yun Chen, Xiu-li Qi
The development of 1,8-naphthalimide derivatives as cell probes, DNA targeting agents, and anti-tumor drugs is one of the research hotspots in the field of medicine. Naphthalimide compounds are a kind of DNA embedder, which can change the topological structure of DNA by embedding in the middle of DNA base pairs, and then affect the recognition and action of topoisomerase on DNA. Aminofide and mitonafide
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PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-16 Alex Stanley Balraj, Sangeetha Muthamilselvan, Rachanaa Raja, Ashok Palaniappan
BackgroundProstate adenocarcinoma (PRAD) is a common cancer diagnosis among men globally, yet large gaps in our knowledge persist with respect to the molecular bases of its progression and aggression. It is mostly indolent and slow-growing, but aggressive prostate cancers need to be recognized early for optimising treatment, with a view to reducing mortality.MethodsBased on TCGA transcriptomic data
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The Role of High Mobility Group Box B-1 in the Prognosis of Colorectal Cancer Based on the Changes in the Intestinal Mucosal Barrier Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-11 Weiwei Zhao, Anqi Chen, Na Yuan, Xiaohui Hao, Cong Wang, Xiurong Lu, Xiao Song, Zhilin Zhang
Background: To investigate the expression of high mobility group box B-1 (HMGB-1) in patients with colorectal cancer (CRC) and its association with clinicopathological features and prognosis in colorectal carcinoma by combining bioinformatics and clinical data analysis, and to clarify the role of HMGB-1. To examine whether HMGB-1 expression is related to the damage of the intestinal mucosal barrier
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Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-09 Ailing Zhong, Chien-shan Cheng, Ren quan Lu, Lin Guo
Background: Deficiencies in DNA damage repair responses promote chemotherapy sensitivity of tumor cells. The Nibrin homolog encoding gene Nijmegen Breakage Syndrome 1 (NBS1) is a crucial component of the MRE11-RAD50-NBN complex (MRN complex) and is involved in the response to DNA double-strand breaks (DSBs) repair that has emerged as an attractive strategy to overcome tumor drug resistance, but the
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Comparison of Machine Learning and Logic Regression Algorithms for Predicting Lymph Node Metastasis in Patients with Gastric Cancer: A two-Center Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-08 Tong Lu, Yu Fang, Haonan Liu, Chong Chen, Taotao Li, Miao Lu, Daqing Song
ObjectivesThis two-center study aimed to establish a model for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning (ML) and logistic regression (LR) algorithms, and to evaluate its predictive performance in clinical practice.MethodsData of a total of 369 patients who underwent radical gastrectomy in the Department of General Surgery of Affiliated Hospital
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Randomized Pilot Study of a Keratin-based Topical Cream for Radiation Dermatitis in Breast Cancer Patients Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-08 Karen M. Winkfield, Ryan T. Hughes, Doris R. Brown, Ryan M. Clohessy, Robert C. Holder, Gregory B. Russell, Alexis F. Rejeski, Luke R. Burnett
Purpose: Radiotherapy (RT) is commonly used in the treatment of breast cancer and often, despite advances in fractionated dosing schedules, produces undesirable skin toxicity. The purpose of this study was to evaluate the feasibility of using a keratin-based topical cream, KeraStat® Cream (KC; KeraNetics, Inc., Winston Salem, NC, USA) to manage the symptoms of radiation dermatitis (RD) in breast cancer
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Attention Connect Network for Liver Tumor Segmentation from CT and MRI Images Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-05 Jiakang Shao, Shunyao Luan, Yi Ding, Xudong Xue, Benpeng Zhu, Wei Wei
Introduction: Currently, the incidence of liver cancer is on the rise annually. Precise identification of liver tumors is crucial for clinicians to strategize the treatment and combat liver cancer. Thus far, liver tumor contours have been derived through labor-intensive and subjective manual labeling. Computers have gained widespread application in the realm of liver tumor segmentation. Nonetheless
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Clinical Characteristics and Outcomes of AIDS-Related Burkitt Lymphoma in China: A Retrospective Single-Center Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-05 Rongqiu Liu, Han Zhao, Guanying Xiao, Yu Tao, Xiaoping Tang, Lizhi Feng, Baolin Liao, Bo Liu, Jialong Guan, Linghua Li, Zhimin Chen, Haolan He, Hua You
Objectives: Studies on the prognosis and risk stratification of patients with acquired immune deficiency syndrome (AIDS) – related Burkitt lymphoma (AR-BL) are rare. We aim to construct a novel model to improve the risk assessment of these patients. Methods: We retrospectively analyzed the clinical data of 34 patients over the past 10 years and the factors associated with progression-free survival
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The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2024-01-05 Chun-Jin Peng, Zhong Fan, Jie-Si Luo, Li-Na Wang, Yu Li, Cong Liang, Xiao-Li Zhang, Xue-Qun Luo, Li-Bin Huang, Yan-Lai Tang
BackgroundAcute myeloid leukemia (AML) with Fms-like tyrosine kinase 3 gene internal tandem duplication (FLT3-ITD) mutations has a poor prognosis. The combination of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) has a synergistic killing effect on leukemia cells with FLT3-ITD mutation. However, the mechanism, especially the changes of gene expression and metabolic activity remain unclear
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Prognostic Parameters of Palbociclib in HR+/HER2- Advanced Breast Cancer: A Narrative Review Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-15 Wei Wang, Jiayi Wu, Keyu Chen, Xiaojia Wang, Xiying Shao
Recent studies have demonstrated that the combination of Cyclin-Dependent Kinase 4/6 Inhibitor (CDK4/6i) and endocrine therapy (ET) is more effective than ET alone and significantly improves progre...
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Noncoplanar Volumetric Modulated Arc Therapy for Hepatocellular Carcinoma Based on a Cage-Like Radiotherapy System: A Simulation Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-15 Min Ma, Chuanmeng Niu, Minghui Li, Deqi Chen, Lingling Yan, Hongkai Wang, Jianrong Dai
BackgroundThe incorporation of noncoplanar beam arrangements has been proposed in liver radiotherapy modalities, which can reduce the dose in normal tissues compared to coplanar techniques. Noncopl...
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A Modified Method for the Quantification of Immune Checkpoint Ligands on Exosomes from Human Serum using Flow Cytometry Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-15 Alan Guillermo Alejandre Gonzalez, Pablo Cesar Ortiz-Lazareno, Fabiola Solorzano-Ibarra, Jorge Gutierrez-Franco, Martha Cecilia Tellez-Bañuelos, Miriam Ruth Bueno-Topete, Susana del Toro-Arreola, Jesse Haramati
Objectives: Exosomes are the smallest of the extracellular vesicles and can contain a variety of different cargos, including nucleic acids, lipids, and proteins. Ultracentrifugation followed by ele...
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Transarterial Chemoembolization Combined With PD-1 Inhibitors Plus Lenvatinib Showed Improved Efficacy for Treatment of Unresectable Hepatocellular Carcinoma Compared With PD-1 Inhibitors Plus Lenvatinib Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-09 Jinfeng Wang, Man Zhao, Guangjie Han, Xin Han, Jianfei Shi, Lili Mi, Ning Li, Xiaolei Yin, Xiaoling Duan, Jiaojiao Hou, Fei Yin
Background: Programmed cell death protein-1 inhibitors combined with lenvatinib have become a popular treatment option for patients with unresectable hepatocellular carcinoma. Transarterial chemoem...
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Patients with Lower Positive Lymph Nodes Ratio May Benefit from Preoperative Radiotherapy in Stage III Non-Small Cell Lung Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-08 Ruiyang Wang, Shijie Shang, Xinyi Huang, Yu Nie, Fei Wang, Jinming Yu, Dawei Chen
BackgroundAlthough preoperative radiotherapy (PORT) is a promising therapeutic option for stage III non-small cell lung cancer (NSCLC), the efficacy of this treatment remains controversial. The pos...
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Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-03 Ahmed A. Abdulhussein Al-Ali, Nameer Al Ward, Mohammad A. Obeid, Carsten Uhd Nielsen, Paul A. Mulheran, Mohammed M. Al Qaraghuli
Recently, much research is focused on the use of photothermal therapy (PTT) as an advanced method to treat various types of cancer. The PTT approach primarily utilizes nanoparticles (NPs) made from...
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Phototherapy: A Conventional Approach to Overcome the Barriers in Oncology Therapeutics Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-05-02 Mohzibudin Z Quazi, Joonyoung Park, Nokyoung Park
Cancer disease has outgrown a life-threatening disease. Having reference to preceding reports provided by the International Agency for Research on Cancer, an estimated 9.6 million deaths transpired...
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Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-28 Filippo Piacentino, Federico Fontana, Giada Zorzetto, Angiola Saccomanno, Sabrina Casagrande, Francesca Franzi, Andrea Imperatori, Carolina Lanza, Serena Carriero, Andrea Coppola, Anna Maria Ierardi, Gianpaolo Carrafiello, Massimo Venturini
Introduction: The purpose of this study is to evaluate the diagnostic value of positron emission computed tomography-cone beam computed tomography (PET/CT-CBCT) fusion guided percutaneous biopsy, t...
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Robotics in Interventional Radiology: Review of Current and Future Applications Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-27 Carolina Lanza, Serena Carriero, Elvira Francisca Maria Buijs, Sveva Mortellaro, Caterina Pizzi, Lucilla Violetta Sciacqua, Pierpaolo Biondetti, Salvatore Alessio Angileri, Andrea Antonio Ianniello, Anna Maria Ierardi, Gianpaolo Carrafiello
This review is a brief overview of the current status and the potential role of robotics in interventional radiology. Literature published in the last decades, with an emphasis on the last 5 years,...
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Histological Response to 5 kHz Irreversible Electroporation in a Porcine Liver Model Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-26 Hong Bae Kim, Ku Youn Baik, Chang Kyu Sung
Unlike necrosis by thermal ablation, irreversible electroporation (IRE) is known to induce apoptosis by disrupting plasma membrane integrity with electric pulses while preserving the structure of b...
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Interobserver Variations in Target Delineation in Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinoma and its Impact on Target Dose Coverage Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-26 Xu Liu, Huixian Huang, Chaohua Zhu, Qihuan Gan, Hailan Jiang, Pei Liu, Xin Qi, Fangfang Fan, Jinru Xiao, Qiang Pang, Zhiping Lu, Heming Lu
BackgroundTo investigate the differences between physicians in target delineation in intensity-modulated radiation therapy for nasopharyngeal carcinoma as well as their impact on target dose covera...
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Tracing 2D Growth of Pancreatic Tumoroids Using the Combination of Image Processing Techniques and Mini-Opto Tomography Imaging System Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-26 Cihat Ediz Akbaba, Adem Polat, Dilek Göktürk
Objectives: In this study, we aimed to trace the 2D growth development of tumoroids produced with MIA PaCa-2 pancreatic cancer cells at different time points. Methods We cultured 3 different tumoro...
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Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-25 Mingdian Tan, Yizhi Ge, Xiaogang Wang, Yan Wang, Yi Liu, Feng He, Hongqi Teng
In recent years, extracellular vesicles (EVs) have gained significant attention due to their tremendous potential for clinical applications. EVs play a crucial role in various aspects, including tu...
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Combination of Novel Therapies and New Attempts in Anaplastic Thyroid Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-25 Wenbo Li, Yue Li, Jia Li, Hua Pang
Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, and it is rapidly falling without any effective therapeutic options. Although radical surgery, radiotherapy, and chemot...
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The Diagnosis Significance of Serum Cysteine Protease Inhibitors (CST4) in Colorectal Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-25 Meiyuan Huang, Zhenyu Yang, Jianqiang Ren, Taoli Wang, Dongliang Chen, Yanqiong Zhan, Wenxing Le, Shuang Deng
ObjectiveThis study aims to evaluate the diagnostic value of human serum cysteine protease inhibitors (cystatin 4 [CST4]) in colorectal cancer (CRC) patients.MethodsA total of 291 patients who were...
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Performance of Pretreatment MRI-Based Radiomics in Recombinant Human Endostatin Plus Concurrent Chemoradiotherapy Response Prediction in Nasopharyngeal Carcinoma: A Retrospective Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-24 Lixuan Huang, Zongxiang Yang, Min Kang, Hao Ren, Muliang Jiang, Cheng Tang, Yao Hu, Mingjun Shen, Huashan Lin, Liling Long
PurposeTo investigate the capability of an Magnetic resonance imaging (MRI) radiomics model based on pretreatment texture features in predicting the short-term efficacy of recombinant human endosta...
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The Value of Circulating Tumor Cells and Tumor Markers Detection in Lung Cancer Diagnosis Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-24 Sumin Guo, Jingyu Chen, Po Hu, Chen Li, Xiang Wang, Ning Chen, Jiale Sun, Yongfeng Wang, Jianling Wang, Weikuan Gu, Shucai Wu
ObjectiveCirculating tumor cells are complete tumor cells with multi-scale analysis values that present a high potential for lung cancer diagnosis. To enhance the accuracy of lung cancer diagnosis,...
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The Regulatory Mechanism and Research Progress of Ferroptosis in Gastric Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Zaibo Zhang, Bingyu Wang, Wenbo Liu, Bibo Tan
Ferroptosis is a novel cell death modality discovered in recent years that is different from apoptosis and necrosis. It is usually associated with changes in the regulatory signaling in multiple or...
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Enrichment of Circulating Tumor Cells of Lung Cancer and Correlation With Serum Leukomonocyte and Tumor Biomarkers: A Retrospective Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Zhou-Fang Mei, Jing Yan, Ling Qian, Yan-Chao He, Jing-Jing Feng, Jie Wang, Zhi-Jun Jie, Hua Zou
Study designCirculating tumor cells is important in the clinical diagnosis of cancer and there are a number of circulating tumor cell detection systems associated with different isolation strategie...
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Competitive Risk Model Nomogram to Predict Prognosis in Patients Aged Over 65 Years with nonmetastatic Cervical Cancer: A SEER Population-Based Study Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Shengyuan Jiao, Li Guo, Fei Da, Qiaohui Gao, Zhenghua Ren, Jianyu Wang, Quanwei Fu, Junye Liu
Objective: The prognostic factors for elderly patients with cervical cancer differ from those of younger patients. Competitive risk events could cause biases in the Cox proportional hazards (PH) mo...
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Prognostic Model and Nomogram for Early-Onset Adenoid Cystic Carcinoma of Head and Neck: A Retrospective SEER-Based Analysis Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Li Dai, Shi-zhou Zhang, Yi-hua Wu
BackgroundAdenoid cystic carcinoma of head and neck (ACCHN) is an uncommon head and neck cancers, whose predilection age is 40 to 60. Some studies have revealed that early-onset cancers, such as co...
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Threshold of Main Pancreatic Duct Diameter in Identifying Malignant Intraductal Papillary Mucinous Neoplasm by Magnetic Resonance Imaging Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Huifeng Zhang, Yingying Cao, Shuai Ren, Kai Guo, Yaping Zhang, Tingting Lin, Yaohui Wang, Xiao Chen, Zhongqiu Wang
Objective: Intraductal papillary mucinous neoplasm (IPMN) is a rare pancreatic lesion. The identification of malignancy is critical for the establishment of treatment strategies. Main pancreatic du...
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All-shot Aspirations in Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Are Associated With Malignancy Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Xuefeng Sun, Ting Zhang, Chi Shao, Ping Wang, Minjiang Chen, Jing Zhao, Mengzhao Wang
Background: Aspirations without a tissue core are common in endobronchial ultrasound-guided transbronchial needle aspiration procedures. However, the diagnostic value of all-shot aspirations and no...
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Antibodies Against Epstein–Barr Virus as Disease Markers of Gastric Cancer: A Systematic Review Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 José I. Fontes-Lemus, Isaac Zhao, Charles S. Rabkin, Ezequiel M. Fuentes-Pananá
Introduction: Gastric cancer is the fourth deadliest cancer worldwide. Due to the lack of specific early symptoms and noninvasive methods for early detection, the prognosis of gastric cancer patien...
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Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-20 Wenyan Yao, Jiang Hu, Peixun Xu, Mengxue He, Yongwen Fang, Mingzhi Liu, Zongtai Li, Huilang He, Hui Liu, Wenzhao Sun, Senkui Xu
BackgroundTo analyze the relationship between the rotational and residual setup errors and the dose deviation on nasopharyngeal carcinoma (NPC) treated by helical tomotherapy (HT).MethodsFrom 25 Ju...
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Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-19 Limeng Yu, Ruilin Wang, Yuhua Zhao, Yingxi Wu, Lili Wang, Haiyang Chen, Zhen He, Qiming Wang, Yufeng Wu
Epidermal growth factor receptor (EGFR) mutations are common driver genes in nonsmall-cell lung cancer and have different sensitivities to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). EGFR is divid...
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The Construction and Validation of a new Predictive Model for Overall Survival of Clear Cell Renal Cell Carcinoma Patients with Bone Metastasis Based on Machine Learning Algorithm Technol. Cancer Res. Treat. (IF 2.8) Pub Date : 2023-04-19 Yijun Le, Wen Xu, Wei Guo
BackgroundThis study aimed to develop and validate predictive models based on machine learning (ML) algorithms for patients with bone metastases (BM) from clear cell renal cell carcinoma (ccRCC) an...