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Deep learning for automatic gross tumor volumes contouring in esophageal cancer based on contrast-enhanced CT images: a multi-institutional study Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-03-02 Shuaitong Zhang, Kunwei Li, Yuchen Sun, Yun Wan, Yong Ao, Yinghua Zhong, Mingzhu Liang, Lizhu Wang, Xiangmeng Chen, Xiaofeng Pei, Yi Hu, Duanduan Chen, Man Li, Hong Shan
To develop and externally validate an automatic Artificial Intelligence (AI) tool for delineating gross tumor volume (GTV) in esophageal squamous cell carcinoma (ESCC) patients, which can assist in the neo-adjuvant or radical radiation therapy treatment planning. In this multi-institutional study, contrast-enhanced CT images from 580 eligible ESCC patients were retrospectively collected. The GTV contours
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Patient Education Practices and Preferences of Radiation Oncologists and Interprofessional Radiation Therapy Care Teams: A Mixed Methods Study Exploring Strategies for Effective Patient Education Delivery Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-03-02 Jie Jane Chen, Anna M. Brown, Allison E. Garda, Ellen Kim, Sarah A. McAvoy, Subha Perni, Michael K. Rooney, Kevin Shiue, Kristi L. Tonning, Laura E. Warren, Daniel W. Golden, Jennifer M. Croke
Patients’ understanding of radiotherapy (RT) and data regarding optimal approaches to patient education (PE) within radiation oncology (RO) are limited. We aimed to evaluate PE practices of radiation oncologists and interprofessional RT care team members to inform recommendations for delivering inclusive and accessible PE. An anonymous survey was administered to all Radiation Oncology Education Collaborative
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Out-of-pocket cost modeling of adjuvant antiestrogen and radiation therapy after lumpectomy for early-stage breast cancer across Medicaid and Medicare plans Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-03-01 Victoria S. Wu, Martha Khlopin, Manjeet Chadha, Demetria J. Smith-Graziani, Reshma Jagsi, Shearwood McClelland
The optimal adjuvant therapy (anti-estrogen therapy (ET) + radiotherapy or ET alone, or in some reports radiotherapy alone) in older women with early-stage breast cancer has been highly debated. However, granular details on the role of insurance in the out-of-pocket cost for patients receiving ET with or without radiotherapy are lacking. This project disaggregates out-of-pocket costs by insurance plans
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A Prospective Study of Machine Learning-Assisted Radiotherapy Planning for Patients Receiving 54 Gy to the Brain Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-03-01 Derek S. Tsang, Grace Tsui, Anna T. Santiago, Harald Keller, Thomas Purdie, Chris Mcintosh, Glenn Bauman, Nancy La Macchia, Amy Parent, Hitesh Dama, Sameera Ahmed, Normand Laperriere, Barbara-Ann Millar, Valerie Liu, David C. Hodgson
The capacity for machine learning (ML) to facilitate radiotherapy (RT) planning for primary brain tumors has not been described. We evaluated ML-assisted RT planning with regards to clinical acceptability, dosimetric outcomes and planning efficiency for adults and children with primary brain tumours. In this prospective study, children and adults receiving 54 Gy fractionated radiotherapy for a primary
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Radiation Therapy Technology Advances and Mitigation of Subsequent Neoplasms in Childhood Cancer Survivors Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-03-01 Camilla H. Stokkevåg, Neige Journy, Ivan R. Vogelius, Rebecca M. Howell, David Hodgson, Søren M. Bentzen
In this Pediatric Normal Tissue Effects in the Clinic (PENTEC) vision paper, challenges and opportunities in the assessment of subsequent neoplasms (SNs) from radiation therapy (RT) are presented and discussed in the context of technology advancement. The paper discusses the current knowledge of SN risks associated with historic, contemporary, and future RT technologies. Opportunities for research
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A Phase I Trial of Salvage Stereotactic Body Radiation Therapy for Radiorecurrent Prostate Cancer After Brachytherapy Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-29 Krishnan R. Patel, Nicholas R. Rydzewski, Erica Schott, Theresa Cooley-Zgela, Holly Ning, Jason Cheng, Kilian Salerno, Erich P. Huang, Liza Lindenberg, Esther Mena, Peter Choyke, Baris Turkbey, Deborah E. Citrin
NCT03253744 is a phase I trial with the primary objective to identify the maximally tolerated dose (MTD) of salvage stereotactic body radiotherapy (SBRT) in patients with local prostate cancer recurrence after brachytherapy. Additional objectives included biochemical control and imaging response. This trial was initially designed to test three therapeutic dose levels (DLs): 40Gy (DL1), 42.5Gy (DL2)
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Experience of Implementing Deep Learning-Based Automatic Contouring in Breast Radiation Therapy Planning: Insights from Over 2,000 Cases Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-29 Byung min Lee, Jin Sung Kim, Yongjin Chang, Seo Hee Choi, Jong Won Park, Hwa Kyung Byun, Yong Bae Kim, Ik Jae Lee, Jee Suk Chang
This study evaluates the impact and clinical utility of an auto-contouring system for radiation therapy treatments. The auto-contouring system was implemented in 2019. We evaluated data from 2,428 patients who underwent adjuvant breast radiation therapy before and after the system's introduction. We collected the treatment's finalized contours, reviewed and revised by multidisciplinary team. After
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Understanding RBE and clinical outcome of prostate cancer therapy using particle irradiation: analysis of tumor control probability with mMKM Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-27 Judith Besuglow, Thomas Tessonnier, Stewart Mein, Tanja Eichkorn, Thomas Haberer, Klaus Herfarth, Amir Abdollahi, Jürgen Debus, Andrea Mairani
: Recent experimental studies and clinical trial results might indicate that - at least for some indications - continued use of the mechanistic model for relative biological effectiveness (RBE) applied at carbon ion therapy facilities in Europe for several decades (LEM-I) may be unwarranted. We present a novel clinical framework for prostate cancer treatment planning and tumor control probability (TCP)
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Optimizing Risk Vs. Reward in the Era of Ablative Radiotherapy Through Calculated Useful Trauma (CUT) Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-23 Nina N. Sanford, Robert D. Timmerman
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No Good Options, or Are There? Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Emma C. Fields
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In Regard to Milano et al. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Eva Onjukka, Kristin Karlsson, Karin Lindberg
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Incidental axillary lymphadenopathy found on radiation planning CT Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Renata Faermann, Miri Sklair-Levy, Anat Shalmon, Osnat Halshtok Neiman, Michael Gotlieb, Yael Yagil, David Samoocha, Shira Galper, Dov Zippel, Tehillah S. Menes, Nora Balint-Lahat, Orit Kaidar-Person
The aim of this study was to evaluate the rate of axillary node positive disease in early breast cancer patients who had a suspicious axillary lymph node on radiation planning CT. A retrospective review of the medical records of all breast cancer patients who were referred for axillary ultrasound from the radiation unit to the breast imaging unit at the Meirav Breast Center, Sheba Medical Center, during
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Exploring the Capabilities and Limitations of Large Language Models for Radiation Oncology Decision Support Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Florian Putz, Marlen Haderlein, Sebastian Lettmaier, Sabine Semrau, Rainer Fietkau, Yixing Huang
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Proton Pencil-Beam Scanning Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Wei Liu, Hongying Feng, Paige A. Taylor, Minglei Kang, Jiajian Shen, Jatinder Saini, Jun Zhou, Huan B. Giap, Nathan Y. Yu, Terence S. Sio, Pranshu Mohindra, Joe Y. Chang, Jeffrey D. Bradley, Ying Xiao, Charles B. Simone, Liyong Lin
Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical organ sparing from both PBSPT and SBRT, this new delivery technique has great potential to improve the therapeutic ratio, particularly for tumors near critical organs
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In Reply to Onjukka et al. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Michael T. Milano, Panayiotis Mavroidis, Ellen Yorke, Jeff Ryckman, Feng-Ming (Spring) Kong, Jimm Grimm, Lawrence B. Marks
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Pelvic Exenteration as the Standard of Care Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Charles S. Dietrich
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Careful Reirradiation Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Jyoti Mayadev
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Late Pulmonary Side Effects: Contemporary Breast Radiation Does Not Take Our Breath Away Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Gerard M. Walls, Carmen Bergom
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An Acceptable Therapeutic Ratio Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Marcus Randall
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Cervical Cancer With Vaginal Recurrence and Prior Pelvic Radiation Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Zeta Chow, Denise Fabian
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Last, But Not the Least … Systemic Treatment is an Option Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Lauren A. Baldwin Branch
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Toward Clinical-Grade Evaluation of Large Language Models Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Amy C. Moreno, Danielle S. Bitterman
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Exposure Is More Than Distance or Time: The Evolution of Competence-Based Medical Education in Radiation Oncology Training Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Paris-Ann Ingledew, Nafisha Lalani, Florence Keane
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Stereotactic Body Radiotherapy (SBRT) for Sacral Metastases: Deviation from Recommended Target Volume Delineation Increases the Risk of Local Failure Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-22 Daniel Moore-Palhares, Kang Liang Zeng, Chia-Lin Tseng, Hanbo Chen, Sten Myrehaug, Hany Soliman, Pejman Maralani, Jeremie Larouche, Husain Shakil, Katarzyna Jerzak, Mark Ruschin, Beibei Zhang, Eshetu G. Atenafu, Arjun Sahgal, Jay Detsky
Although spine stereotactic body radiotherapy (SBRT) is considered a standard of care in the mobile spine, mature evidence reporting outcomes specific to sacral metastases is lacking. Furthermore, there is a need to validate the existing sacral SBRT international consensus contouring guidelines to define the optimal contouring approach. We report mature rates of local failure (LF), adverse events,
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Disease control and late toxicity in Adaptive Dose Painting by Numbers vs. non-adaptive radiotherapy for head and neck cancer: a randomized controlled phase II trial Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-21 Aurélie De Bruycker, Wilfried De Neve, Jean-François Daisne, Tom Vercauteren, Werner De Gersem, Luiza Olteanu, Dieter Berwouts, Stéphanie Deheneffe, Indira Madani, Ingeborg Goethals, Fréderic Duprez
Local recurrence remains the main cause of death in stage III-IV non-metastatic head-and-neck cancer (HNC) with relapse-prone regions within high F-FDG-PET-signal gross tumor volume. We investigated if dose-escalation within this subvolume combined with a 3-phase treatment-adaptation could increase local (LC) and regional (RC) control at equal or minimized radiation-induced toxicity, by comparing adaptive
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Psychosocial factors that influence a woman's decision to enroll in a clinical trial – implications on how to improve clinical trial enrollment among Black women Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-21 Uma Markan, Kaysee Baker, Caitlin Eggleston, Sally B. Cheston, Pranshu Mohindra, Elizabeth Nichols, Sarah McAvoy, Søren M. Bentzen, Melissa A.L. Vyfhuis
Black women with breast cancer often present with more aggressive disease when compared to other races, contributing to an increased risk of cancer mortality. Despite this inequity, Black women remain severely underrepresented in breast cancer clinical trials. We aim to characterize factors that influence a woman's decision to enroll in a clinical trial, with the goal of identifying clinical interventions
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A novel framework for thermoradiotherapy treatment planning Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-20 Jakob Ödén, Kjell Eriksson, Brando Pavoni, Hans Crezee, H. Petra Kok
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A Phase 2 Randomized Clinical Trial Evaluating 4DCT Ventilation-based Functional Lung Avoidance Radiotherapy for Non-Small Cell Lung Cancer Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-20 Andrew M. Baschnagel, Mattison J. Flakus, Eric M. Wallat, Antonia E. Wuschner, Richard J. Chappell, R. Adam Bayliss, Randall J. Kimple, Gary E. Christensen, Joseph M. Reinhardt, Michael F. Bassetti, John E. Bayouth
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Acute hypoxia does not alter tumor sensitivity to FLASH radiotherapy Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-20 Ron J. Leavitt, Aymeric Almeida, Veljko Grilj, Pierre Montay-Gruel, Céline Godfroid, Benoit Petit, Claude Bailat, Charles L. Limoli, Marie-Catherine Vozenin
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A Phase II Trial of Primary Tumor SBRT Boost Prior to Concurrent Chemoradiation for Locally-Advanced Non-Small Cell Lung Cancer Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-20 Terence M. Williams, Eric Miller, Meng Welliver, Jeremy Brownstein, Gregory Otterson, Dwight Owen, Karl Haglund, Peter Shields, Erin Bertino, Carolyn Presley, Kai He, Jacob Naduparambil, Steve Walston, Jeff Pan, Xiangyu Yang, Michael Knopp, Jean Koutou Essan, Joseph McElroy, Xiaokui Mo, Sohyun McElroy, David Carbone, Jose Bazan
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Women in the Medical Physics Workforce: Insights from AAPM Membership Trends, 1993-2023 Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-20 Jillian Rankin, Jenna Bedrava, Elizabeth Covington, Jennifer Lynn Johnson, Julianne Pollard-Larkin, Matthew Schipper, Richard Castillo, Michael Woodward, Yan-Hong Xing, Kelly C Paradis
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Microbeam Radiation Therapy opens a several days vessel permeability window for small molecules in brain tumor vessels Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-18 Potez Marine, Rome Claire, Lemasson Benjamin, Heemeryck Pierre, Laissue Jean Albert, Stupar Vasile, Mathieu Hervé, Collomb Nora, Barbier Emmanuel, Djonov Valentin, Bouchet Audrey
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Magnetic Resonance Imaging Frequency after Stereotactic Body Radiation Therapy for Spine Metastases Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-17 Hanbo Chen, Eshetu G. Atenafu, K. Liang Zeng, Aimee Chan, Jay Detsky, Sten Myrehaug, Hany Soliman, Chia-Lin Tseng, Arjun Sahgal, Pejman J. Maralani
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Clinical Experience with an Offline ART Head and Neck Program: Dosimetric Benefits and Opportunities for Patient Selection Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-17 Michalis Aristophanous, Eric Aliotta, Phillip Lichtenwalner, Shira Abraham, Mohammad Nehmeh, Amanda Caringi, Peng Zhang, Yu-Chi Hu, Pengpeng Zhang, Laura Cervino, Daphna Gelblum, Sean McBride, Nadeem Riaz, Linda Chen, Yao Yu, Kaveh Zakeri, Nancy Lee
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Voxel-level dosimetry for combined Iodine-131 radiopharmaceutical therapy and external beam radiotherapy treatment paradigms of head and neck cancer Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-16 David P. Adam, Joseph J. Grudzinski, Ian R. Marsh, Patrick M. Hill, Steve Y. Cho, Tyler J. Bradshaw, Jarrod Longcor, Adam Burr, Justine Y. Bruce, Paul M. Harari, Bryan P. Bednarz
Targeted radiopharmaceutical therapy (RPT) in combination with external beam radiotherapy (EBRT) shows promise as a method to increase tumor control and mitigate potential high-grade toxicities associated with re-treatment for patients with recurrent head and neck cancer. This work establishes a patient-specific dosimetry framework that combines Monte Carlo based dosimetry from the two radiation modalities
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Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG) Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Oscar Padilla, Hanna E. Minnsm, Hong-Jian Wei, Weijia Fan, Andrea Webster-Carrionm, Masih Tazhibi, Nicholas M. McQuillan, Xu Zhang, Matthew Gallitto, Rebecca Yeh, Zhiguo Zhang, Tom K. Hei, Luca Szalontay, Jovana Pavisic, Yuewen Tan, Naresh Deoli, Guy Garty, James H. Garvin, Peter D. Canoll, Claire Vanpouille-Box, Vilas Menon, Marta Olah, Raul Rabadan, Cheng-Chia Wu, Robyn D. Gartrell
Diffuse Midline Glioma (DMG) is a fatal tumor traditionally treated with radiotherapy (RT) and previously characterized as having a non-inflammatory tumor immune microenvironment (TIME). FLASH is a novel RT technique using ultra-high dose rate, which is associated with decreased toxicity and effective tumor control. However, the effect of FLASH and conventional (CONV) RT on the DMG TIME have not yet
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USP11 exacerbates radiation induced pneumonitis by activating endothelial cell inflammatory response via OTUD5-STING signaling Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Yiting Tang, Tingya Wang, Liming Gu, Ying Xu, Zhao Yang, Wei Zhu, Qi Zhang, Judong Luo, Jianping Cao, Yang Jiao
Radiation induced pneumonitis (RIP) seriously limits the application of radiotherapy in the treatment of thoracic tumors, and its etiology and pathogenesis remain elusive. This study aims to elucidate the role of Ubiquitin-specific peptidase 11 (USP11) in the progression of RIP and the associated underlying mechanisms. The changes of cytokines and infiltrated immune cells were detected by ELISA and
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FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Kyle Kim, Michele M. Kim, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Alexander Lin, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Constantinos Koumenis, Ioannis I. Verginadis
Studies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as “FLASH” radiotherapy, enhances the therapeutic index of radiation therapy (RT) by decreasing normal tissue damage while maintaining tumor response compared to conventional (or standard) RT. This study demonstrates the cardioprotective benefits of FLASH proton RT (F-PRT) compared to standard (conventional)
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Safety and Efficiency Analysis of Operational Decision-Making During CBCT-Based Online Adaptive Radiotherapy Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Lawrence M. Wong, Mikel Byrne, Erik van Dieren, Lisanne Zwart, Xenia Ray, Joseph Harms, Trent Aland, Dennis Stanley, Todd Pawlicki
Cone beam computed tomography (CBCT)-based online adaptive radiotherapy (ART) is especially beneficial for patients with large inter-fractional anatomical changes. However, treatment planning and review decisions need to be made at the treatment console in real-time and may be delegated to clinical staff whose conventional scope of practice does not include making such decisions. Therefore, implementation
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Liver-directed combined radiotherapy for downstaging beyond-Milan hepatocellular carcinoma to liver transplantation Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Jina Kim, Yong Tae Kim, Jae Geun Lee, Dai Hoon Han, Dong Jin Joo, Do Young Kim, Jinsil Seong
Curative surgery involving either resection or liver transplantation (LT) is indicated only for early stage hepatocellular carcinoma (HCC). Over the years, numerous efforts have been made to downstage advanced HCC to curative surgery using various locoregional therapies. In this study, we investigated the role of liver-directed combined radiotherapy (LD-CRT) as a downstaging strategy for converting
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Real-world experience in Hispanic Patients with Breast Cancer and Brain Metastases using different Prognostic Tools. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 Bernardo Cacho-Díaz, Debu Tripathy, Victor A. Arrieta, Angel Escamilla-Ramirez, Alberto Alvarado-Miranda, Oscar Rodríguez-Mayoral
Only a small percentage of Hispanic patients have been included in studies that developed prognostic models for breast cancer and brain metastases. Therefore, there is a clear need for tools tailored to this demographic. This study assesses the efficacy of common prognostic tools in a Hispanic population. We retrospectively analyzed a dataset of Hispanic patients with breast cancer and newly diagnosed
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Are We Missing Acute Toxicities Associated with Hypofractionated Breast Irradiation? A Report from a Large Multi-Center Cohort Study Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-15 H. Beydoun, K.A. Griffith, R. Jagsi, J.W. Burmeister, J.M. Moran, F.A. Vicini, J.A. Hayman, P. Paximadis, T.P. Boike, E.M. Walker, L.J. Pierce, M.M. Dominello
The efficacy and long-term safety of hypofractionated whole breast irradiation (HF-WBI) has been established through multiple randomized trials, yet data about acute toxicities remains more limited. Since 2013, our group has prospectively collected acute toxicity data from weekly treatment evaluations and additional assessment after completion. In 2016, we intentionally shifted the post-treatment assessment
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Pneumonitis risk after chemoradiotherapy with and without immunotherapy in patients with locally advanced non-small cell lung cancer: A systematic review and meta-analysis Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-13 Chong Han, Jingping Qiu, Lu Bai, Tingting Liu, Jun Chen, He Wang, Jun Dang
Chemoradiotherapy (CRT) combined with immune checkpoint inhibitors (ICIs) is the standard of care for patients with unresectable and locally advanced non-small cell lung cancer. This study aimed to determine whether the addition of ICIs to CRT is associated with an increased risk of pneumonitis. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for eligible studies published
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Differential remodeling of the oxylipin pool following FLASH vs. conventional dose-rate irradiation in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-08 Lucie Portier, Patricia Daira, Baptiste Fourmaux, Sophie Heinrich, Margaux Becerra, Charles Fouillade, Nathalie Berthault, Marie Dutreix, Arturo Londoño-Vallejo, Pierre Verrelle, Nathalie Bernoud-Hubac, Vincent Favaudon
Ultrahigh performance liquid chromatography coupled to tandem mass spectrometry was used to quantify the expression of 37 oxylipins derived from eicosatetraenoic, eicosapentaenoic and docosahexaenoic acid in mouse lung and in normal or cancer cells exposed to ultrahigh (FLASH) conventional dose-rate irradiation (CONV) under precise monitoring of the temperature and oxygenation. Among the 37 isomers
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In Reply to Yamazaki et al. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Takeshi Kodaira, Yoshikazu Kagami, Naoto Shikama
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Erratum to: Fields EC, Erickson B, Hubbard A, Chino J, Small C, Weiner A, Petereit D, Mayadev JS, Yashar CM, Joyner M. Tipping the Balance: Adding Resources for Cervical Cancer Brachytherapy. Int J Radiat Oncol Biol Phys 2023;117:1138–1142 Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Emma C. Fields, Beth Erickson, Anne Hubbard, Junzo Chino, Christina Small, Ashley Weiner, Daniel Petereit, Jyoti S. Mayadev, Catheryn M. Yashar, Melissa Joyner
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Don't Wait, Consolidate! Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Niema B. Razavian, Michael Farris
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A Pawn's Sacrifice: Go for the Win Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Andrew J. Hunt, Neil B. Newman
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Erratum to: Jeans EB, Brower JV, Burmeister JW, Deville C, Fields E, Kavanagh BD, Suh JH, Tekian A, Vapiwala N, Zeman EM, Golden DW. Development of a United States Radiation Oncology Curricular Framework: A Stakeholder Delphi Consensus. Int J Radiat Oncol Biol Phys 2023;115:1030–1040 Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07
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What if Perioperative Therapy for Non-Small Cell Lung Cancer Renders Someone Inoperable? Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Muhammad Shuja, Dawn Owen
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Neoadjuvant Chemoimmunotherapy for Initially Resectable Non-Small Cell Lung Cancer: Queen's Gambit or CheckMate? Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Alyssa Farley, Bailey Nelson
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Cautionary Tale: Excess Toxicity With DNA-Dependent Protein Kinase Inhibitor and Concurrent Cisplatin-Based Chemoradiation for Head and Neck Cancer Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Yvonne M. Mowery
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In Regard to Kodaira et al. Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Hideya Yamazaki, Gen Suzuki, Norihiro Aibe, Ken Yoshida, Satoaki Nakamura
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Trials and Technology to Advance Upper Gastrointestinal Oncology: Imagination, Imaging, and the Intertwined Imperfections Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Hyun Kim, Michael D. Chuong, Maria A. Hawkins, Krishan R. Jethwa, Ann C. Raldow, Nina N. Sanford, Andrzej P. Wojcieszynski, Jeffrey R. Olsen
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Empirically Derived Principles for Research Funding Success: A Primer for Early Career Academic Investigators Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Kareem A. Wahid, Michael K. Rooney, Jillian R. Gunther, Amy C. Moreno, Chelsea C. Pinnix, Charles R. Thomas, Clifton D. Fuller
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CheckMate Check-In: Playbook for a Cancelled Surgery Int. J. Radiat. Oncol. Biol. Phys. (IF 7.0) Pub Date : 2024-02-07 Shahed N. Badiyan, Kenneth Westover