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Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer. Cancers (IF 5.2) Pub Date : 2023-11-20 Yukako Ito,Shinji Kobuchi,Amiri Kawakita,Kazuki Tosaka,Yume Matsunaga,Shoma Yoshioka,Shizuka Jonan,Kikuko Amagase,Katsunori Hashimoto,Mitsuro Kanda,Takuya Saito,Hayao Nakanishi
Mobilization of CTCs after various types of therapy, such as radiation therapy, has been reported, but systematic study of CTCs after chemotherapy remained quite limited. In this study, we sequentially examined CTC numbers after single-dose and repetitive-dose chemotherapy, including FORFIRINOX (FFX) and Gemcitabine and nab-Paclitaxel (GnP) using two pancreatic cancer xenograft models. CTC was detected
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A Clinical Viewpoint on the Use of Targeted Therapy in Advanced Gastric Cancer. Cancers (IF 5.2) Pub Date : 2023-11-20 Magdalena Skórzewska,Katarzyna Gęca,Wojciech P Polkowski
The development of therapies for advanced gastric cancer (GC) has made significant progress over the past few years. The identification of new molecules and molecular targets is expanding our understanding of the disease's intricate nature. The end of the classical oncology era, which relied on well-studied chemotherapeutic agents, is giving rise to novel and unexplored challenges, which will cause
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The Role of the Tumor Microenvironment in Triple-Positive Breast Cancer Progression and Therapeutic Resistance. Cancers (IF 5.2) Pub Date : 2023-11-20 Qian Pu,Haidong Gao
Breast cancer (BRCA) is a highly heterogeneous systemic disease. It is ranked first globally in the incidence of new cancer cases and has emerged as the primary cause of cancer-related death among females. Among the distinct subtypes of BRCA, triple-positive breast cancer (TPBC) has been associated with increased metastasis and invasiveness, exhibiting greater resistance to endocrine therapy involving
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Setup Uncertainty of Pediatric Brain Tumor Patients Receiving Proton Therapy: A Prospective Study. Cancers (IF 5.2) Pub Date : 2023-11-20 Jared Becksfort,Jinsoo Uh,Andrew Saunders,Julia A Byrd,Hannah M Worrall,Matt Marker,Christian Melendez-Suchi,Yimei Li,Jenghwa Chang,Kavitha Raghavan,Thomas E Merchant,Chia-Ho Hua
This study quantifies setup uncertainty in brain tumor patients who received image-guided proton therapy. Patients analyzed include 165 children, adolescents, and young adults (median age at radiotherapy: 9 years (range: 10 months to 24 years); 80 anesthetized and 85 awake) enrolled in a single-institution prospective study from 2020 to 2023. Cone-beam computed tomography (CBCT) was performed daily
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Development and Validation of a Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A 6-Year, Multicenter, Retrospective and Prospective Diagnostic Cohort Study. Cancers (IF 5.2) Pub Date : 2023-11-20 Deshan Liu,Dixiang Song,Weihai Ning,Yuduo Guo,Ting Lei,Yanming Qu,Mingshan Zhang,Chunyu Gu,Haoran Wang,Junpeng Ji,Yongfei Wang,Yao Zhao,Nidan Qiao,Hongwei Zhang
BACKGROUND Based on the literature and data on its clinical trials, the incidence of venous thromboembolism (VTE) in patients undergoing neurosurgery has been 3.0%~26%. We used advanced machine learning techniques and statistical methods to provide a clinical prediction model for VTE after neurosurgery. METHODS All patients (n = 5867) who underwent neurosurgery from the development and retrospective
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Lobular Carcinoma of the Breast: A Comprehensive Review with Translational Insights. Cancers (IF 5.2) Pub Date : 2023-11-20 Harsh Batra,Jason Aboudi Mouabbi,Qingqing Ding,Aysegul A Sahin,Maria Gabriela Raso
The second most common breast carcinoma, invasive lobular carcinoma, accounts for approximately 15% of tumors of breast origin. Its incidence has increased in recent times due in part to hormone replacement therapy and improvement in diagnostic modalities. Although believed to arise from the same cell type as their ductal counterpart, invasive lobular carcinomas (ILCs) are a distinct entity with different
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Salvage Radical Prostatectomy for Recurrent Prostate Cancer: A Systematic Review (French ccAFU). Cancers (IF 5.2) Pub Date : 2023-11-20 Amine Saouli,Alain Ruffion,Charles Dariane,Eric Barret,Gaëlle Fiard,Gaelle Fromont Hankard,Gilles Créhange,Guilhem Roubaud,Jean Baptiste Beauval,Laurent Brureau,Raphaëlle Renard-Penna,Mathieu Gauthé,Michael Baboudjian,Guillaume Ploussard,Morgan Rouprêt
The aim of this study was to systematically review the current evidence regarding the oncological and functional outcomes of salvage radical prostatectomy (sRP) for recurrent prostate cancer. A systematic review was conducted throughout September 2022 using the PubMed, Science Direct, Scopus, and Embase databases. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines
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Targeting Myeloid-Derived Suppressor Cell Trafficking as a Novel Immunotherapeutic Approach in Microsatellite Stable Colorectal Cancer. Cancers (IF 5.2) Pub Date : 2023-11-20 Benny Johnson
Myeloid-derived suppressor cells (MDSCs) are a unique subset of immune cells that promote an immunosuppressive phenotype due to their impacts on CD8 and regulatory T cell function. The inhibition of MDSC trafficking to the tumor microenvironment (TME) may represent a novel target in microsatellite stable (MSS) colorectal cancer with the potential to reprogram the immune system. Here, we review the
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Robotic Distal Pancreatectomy Yields Superior Outcomes Compared to Laparoscopic Technique: A Single Surgeon Experience of 123 Consecutive Cases. Cancers (IF 5.2) Pub Date : 2023-11-20 Hao Ding,Michal Kawka,Tamara M H Gall,Chris Wadsworth,Nagy Habib,David Nicol,David Cunningham,Long R Jiao
Technical limitations of laparoscopic distal pancreatectomy (LDP), in comparison to robotic distal pancreatectomy (RDP), may translate to high conversion rates and morbidity. LDP and RDP procedures performed between December 2008 and January 2023 in our tertiary referral hepatobiliary and pancreatic centres were analysed and compared with regard to short-term outcomes. A total of 62 consecutive LDP
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Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy. Cancers (IF 5.2) Pub Date : 2023-11-20 Masayoshi Yamaguchi
Regucalcin, a calcium-binding protein lacking the EF-hand motif, was initially discovered in 1978. Its name is indicative of its function in calcium signaling regulation. The rgn gene encodes for regucalcin and is situated on the X chromosome in both humans and vertebrates. Regucalcin regulates pivotal enzymes involved in signal transduction and has an inhibitory function, which includes protein kinases
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The Promise of Piperine in Cancer Chemoprevention. Cancers (IF 5.2) Pub Date : 2023-11-20 Salma Benayad,Hicham Wahnou,Riad El Kebbaj,Bertrand Liagre,Vincent Sol,Mounia Oudghiri,El Madani Saad,Raphaël Emmanuel Duval,Youness Limami
Cancer, characterized by the unregulated growth and dissemination of malignantly transformed cells, presents a significant global health challenge. The multistage process of cancer development involves intricate biochemical and genetic alterations within target cells. Cancer chemoprevention has emerged as a vital strategy to address this complex issue to mitigate cancer's impact on healthcare systems
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CBCT-to-CT Synthesis for Cervical Cancer Adaptive Radiotherapy via U-Net-Based Model Hierarchically Trained with Hybrid Dataset. Cancers (IF 5.2) Pub Date : 2023-11-20 Xi Liu,Ruijie Yang,Tianyu Xiong,Xueying Yang,Wen Li,Liming Song,Jiarui Zhu,Mingqing Wang,Jing Cai,Lisheng Geng
PURPOSE To develop a deep learning framework based on a hybrid dataset to enhance the quality of CBCT images and obtain accurate HU values. MATERIALS AND METHODS A total of 228 cervical cancer patients treated in different LINACs were enrolled. We developed an encoder-decoder architecture with residual learning and skip connections. The model was hierarchically trained and validated on 5279 paired
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Cardiotoxicity Associated with Immune Checkpoint Inhibitors. Cancers (IF 5.2) Pub Date : 2023-11-20 Shintaro Minegishi,Nobuyuki Horita,Tomoaki Ishigami,Kiyoshi Hibi
Immune checkpoint inhibitors (ICIs) have shown significant efficacy in various cancers, including non-small cell lung cancer, small cell lung cancer, melanoma, classical Hodgkin lymphoma, head and neck squamous cell carcinoma, urothelial cancer, and renal cell carcinoma [...].
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Lymph Node Molecular Analysis with OSNA Enables the Identification of pT1 CRC Patients at Risk of Recurrence: A Multicentre Study. Cancers (IF 5.2) Pub Date : 2023-11-20 Karmele Saez de Gordoa,Maria Teresa Rodrigo-Calvo,Ivan Archilla,Sandra Lopez-Prades,Alba Diaz,Jordi Tarragona,Isidro Machado,Juan Ruiz Martín,Diana Zaffalon,Maria Daca-Alvarez,Maria Pellisé,Jordi Camps,Miriam Cuatrecasas
Early-stage colorectal carcinoma (CRC)-pT1-is a therapeutic challenge and presents some histological features related to lymph node metastasis (LNM). A significant proportion of pT1 CRCs are treated surgically, resulting in a non-negligible surgical-associated mortality rate of 1.5-2%. Among these cases, approximately 6-16% exhibit LNM, but the impact on survival is unclear. Therefore, there is an
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Higher Content but No Specific Activity in Gelatinase B (MMP-9) Compared with Gelatinase A (MMP-2) in Human Renal Carcinoma. Cancers (IF 5.2) Pub Date : 2023-11-20 Grzegorz Młynarczyk,Monika Gudowska-Sawczuk,Barbara Mroczko,Marta Bruczko-Goralewska,Lech Romanowicz,Anna Tokarzewicz
Gelatinases belong to a group of enzymes known as matrix metalloproteinases (MMPs). Gelatinases A and B (MMP-2 and MMP-9, respectively) are the enzymes with the highest ability to destroy collagen, primarily type IV collagen, which is an essential component of the base membrane. Hence, it can be assumed that they are involved, among other things, with the metastasis process of cancer. As a result,
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The Risk of Venous Thromboembolism in Neuroendocrine Neoplasms. Cancers (IF 5.2) Pub Date : 2023-11-20 Monika Wójcik-Giertuga,Anna Malczewska-Herman,Beata Kos-Kudła
Neuroendocrine neoplasms (NENs) differ from other malignancies in their ability to produce hormones and biogenic amines, as well as offer a better prognosis in well-differentiated tumors. There are no definite data on the occurrence of thromboembolic events in NENs and no recommendations regarding the use of antithrombotic prophylaxis in this group. Accurate assessment of the thromboembolic risk in
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Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery. Cancers (IF 5.2) Pub Date : 2023-11-20 Iliyana Sazdova,Milena Keremidarska-Markova,Daniela Dimitrova,Vadim Mitrokhin,Andre Kamkin,Nikola Hadzi-Petrushev,Jane Bogdanov,Rudolf Schubert,Hristo Gagov,Dimiter Avtanski,Mitko Mladenov
EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient metabolism, ensuring optimal bioavailability and sustained exposure of the target tissues. The ability of EF24 to penetrate biological barriers and accumulate at tumor
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An Innovative Non-Linear Prediction Model for Clinical Benefit in Women with Newly Diagnosed Breast Cancer Using Baseline FDG-PET/CT and Clinical Data. Cancers (IF 5.2) Pub Date : 2023-11-20 Ken Kudura,Nando Ritz,Arnoud J Templeton,Tim Kutzker,Martin H K Hoffmann,Kwadwo Antwi,Daniel R Zwahlen,Michael C Kreissl,Robert Foerster
Objectives: We aimed to develop a novel non-linear statistical model integrating primary tumor features on baseline [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), molecular subtype, and clinical data for treatment benefit prediction in women with newly diagnosed breast cancer using innovative statistical techniques, as opposed to conventional methodological
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Can We Predict Skeletal Lesion on Bone Scan Based on Quantitative PSMA PET/CT Features? Cancers (IF 5.2) Pub Date : 2023-11-19 Riccardo Laudicella,Matteo Bauckneht,Alexander Maurer,Jakob Heimer,Antonio G Gennari,Tania Di Raimondo,Gaetano Paone,Marco Cuzzocrea,Michael Messerli,Daniel Eberli,Irene A Burger
OBJECTIVE The increasing use of PSMA-PET/CT for restaging prostate cancer (PCa) leads to a patient shift from a non-metastatic situation based on conventional imaging (CI) to a metastatic situation. Since established therapeutic pathways have been designed according to CI, it is unclear how this should be translated to the PSMA-PET/CT results. This study aimed to investigate whether PSMA-PET/CT and
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The Role of Post-Mastectomy Radiotherapy in T1-2N1 Breast Cancer Patients: Propensity Score Matched Analysis. Cancers (IF 5.2) Pub Date : 2023-11-19 Kangpyo Kim,Won Park,Haeyoung Kim,Won Kyung Cho,Nalee Kim,Seok Jin Nam,Seok Won Kim,Jeong Eon Lee,Jonghan Yu,Byung Joo Chae,Se Kyung Lee,Jai Min Ryu
This study aimed to evaluate the role of post-mastectomy radiotherapy (PMRT) in T1-2N1 breast cancer. Between 2006 and 2014, a total of 504 patients with T1-2N1 breast cancer were analyzed. PMRT was administered to 71 patients, and 1:2 propensity score matching (PSM) was performed between the PMRT and non-PMRT groups. Loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS)
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Combined Serum ALBUMIN with Neutrophil-to-Lymphocyte Ratio Predicts the Prognosis of Biliary Tract Cancer after Curative Resection. Cancers (IF 5.2) Pub Date : 2023-11-19 Tai-Jan Chiu,Yueh-Wei Liu,Chee-Chien Yong,Shih-Min Yin,Cheng-His Yeh,Yen-Yang Chen
BACKGROUND The mainstay treatment of biliary tract cancer is complete tumor resection. Prior to surgery, risk stratification may help to predict and plan treatment approaches. In this study, we investigated the possibility of combining serum albumin concentrations and neutrophil-to-lymphocyte ratios (NLR) to create a score as ANS to predict the prognoses of biliary tract cancer before surgery. METHODS
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Cytogenetics Is a Science, Not a Technique! Why Optical Genome Mapping Is So Important to Clinical Genetic Laboratories. Cancers (IF 5.2) Pub Date : 2023-11-19 Adam C Smith,Alexander Hoischen,Gordana Raca
Karyotyping is a technique that has been used in clinical cytogenetic laboratories for more than 40 years [...].
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Multiparametric MRI in Era of Artificial Intelligence for Bladder Cancer Therapies. Cancers (IF 5.2) Pub Date : 2023-11-18 Oguz Akin,Alfonso Lema-Dopico,Ramesh Paudyal,Amaresha Shridhar Konar,Thomas L Chenevert,Dariya Malyarenko,Lubomir Hadjiiski,Hikmat Al-Ahmadie,Alvin C Goh,Bernard Bochner,Jonathan Rosenberg,Lawrence H Schwartz,Amita Shukla-Dave
This review focuses on the principles, applications, and performance of mpMRI for bladder imaging. Quantitative imaging biomarkers (QIBs) derived from mpMRI are increasingly used in oncological applications, including tumor staging, prognosis, and assessment of treatment response. To standardize mpMRI acquisition and interpretation, an expert panel developed the Vesical Imaging-Reporting and Data System
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Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies. Cancers (IF 5.2) Pub Date : 2023-11-18 Eelco de Bree,Dimosthenis Michelakis,Ioannis Heretis,Nikolaos Kontopodis,Konstantinos Spanakis,Eleni Lagoudaki,Maria Tolia,Michail Zografakis-Sfakianakis,Christos Ioannou,Dimitrios Mavroudis
Retroperitoneal soft tissue sarcoma (RPS) is a rare and heterogenous disease for which surgery is the cornerstone of treatment. However, the local recurrence rate is much higher than in soft tissue sarcoma of the extremities since wide resection is usually unfeasible in RPS due to its large size, indistinct tumour borders, anatomical constraints and the thinness of the overlying peritoneum. Local recurrence
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Thoracoscopy for Pediatric Thoracic Neurogenic Tumors-A European Multi-Center Study. Cancers (IF 5.2) Pub Date : 2023-11-18 Jean François Lecompte,Sabine Sarnacki,Sabine Irtan,Christian Piolat,Aurélien Scalabre,Isabelle Talon,Julien Rod,Nicoleta Panait,Gregory Rodesch,Ana Lourdes Luis Huertas,Olivier Abbo,Martine Demarche,Edouard Habonimana,Quentin Ballouhey,Dominique Valteau-Couanet,Florent Guérin
OBJECTIVES To assess the efficacy of thoracoscopy and the outcome for children with thoracic neurogenic tumors. METHODS We performed a retrospective review of 15 European centers between 2000 and 2020 with patients who underwent thoracoscopy for a neurogenic mediastinal tumor. We assessed preoperative data, complications, and outcomes. Results were expressed with the median and range values. RESULTS
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Epidemiology of Neuroendocrine Neoplasms and Results of Their Treatment with [177Lu]Lu-DOTA-TATE or [177Lu]Lu-DOTA-TATE and [90Y]Y-DOTA-TATE-A Six-Year Experience in High-Reference Polish Neuroendocrine Neoplasm Center. Cancers (IF 5.2) Pub Date : 2023-11-18 Adam Daniel Durma,Marek Saracyn,Maciej Kołodziej,Katarzyna Jóźwik-Plebanek,Beata Dmochowska,Waldemar Kapusta,Wawrzyniec Żmudzki,Adrianna Mróz,Beata Kos-Kudła,Grzegorz Kamiński
Neuroendocrine neoplasms (NENs) are a group of neoplasms arising from neuroendocrine cells. The worldwide incidence and prevalence of the NENs are estimated to be 6/100,000 and 35/100,000, respectively. Those numbers are increasing every decade, requiring higher and higher diagnosis and treatment costs. Radioligand therapy (RLT) using beta-emitting radioisotopes is an efficient and relatively safe
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Unveiling Disrupted Lipid Metabolism in Benign Prostate Hyperplasia, Prostate Cancer, and Metastatic Patients: Insights from a Colombian Nested Case-Control Study. Cancers (IF 5.2) Pub Date : 2023-11-18 Daniel Pardo-Rodriguez,Mary Santamaría-Torres,Angela Salinas,Eliécer Jiménez-Charris,Mildrey Mosquera,Mónica P Cala,Herney Andrés García-Perdomo
Prostate cancer is a significant global health concern, and its prevalence is increasing worldwide. Despite extensive research efforts, the complexity of the disease remains challenging with respect to fully understanding it. Metabolomics has emerged as a powerful approach to understanding prostate cancer by assessing comprehensive metabolite profiles in biological samples. In this study, metabolic
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Quantification of Gleason Pattern 4 at MRI-Guided Biopsy to Predict Adverse Pathology at Radical Prostatectomy in Intermediate-Risk Prostate Cancer Patients. Cancers (IF 5.2) Pub Date : 2023-11-17 Hubert Kamecki,Łukasz Mielczarek,Stanisław Szempliński,Małgorzata Dębowska,Paweł Rajwa,Michael Baboudjian,Jakob Klemm,Juan Gómez Rivas,Elza Modzelewska,Omar Tayara,Wojciech Malewski,Przemysław Szostek,Sławomir Poletajew,Piotr Kryst,Roman Sosnowski,Łukasz Nyk
BACKGROUND Data on Gleason pattern 4 (GP4) amount in biopsy tissue is important for prostate cancer (PC) risk assessment. We aim to investigate which GP4 quantification method predicts adverse pathology (AP) at radical prostatectomy (RP) the best in men diagnosed with intermediate-risk (IR) PC at magnetic resonance imaging (MRI)-guided biopsy. METHODS We retrospectively included 123 patients diagnosed
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The Diagnostic and Predictive Value of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Laryngeal Squamous Cell Carcinoma. Cancers (IF 5.2) Pub Date : 2023-11-17 Akram Al-Ibraheem,Ahmed Saad Abdlkadir,Qaid Ahmed Shagera,Omar Saraireh,Dhuha Al-Adhami,Rakan Al-Rashdan,Farah Anwar,Serin Moghrabi,Issa Mohamad,Kristoff Muylle,Enrique Estrada,Diana Paez,Asem Mansour,Egesta Lopci
This retrospective study examines the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and neck magnetic resonance imaging (MRI) in detecting nodal metastasis for patients with laryngeal squamous cell carcinoma (LSCC) and assesses the predictive values of metabolic and structural features derived from 18F-FDG PET/CT. By involving 66 patients
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Computational Multi-Scale Modeling of Drug Delivery into an Anti-Angiogenic Therapy-Treated Tumor. Cancers (IF 5.2) Pub Date : 2023-11-17 Mahya Mohammadi,Mostafa Sefidgar,Cyrus Aghanajafi,Mohammad Kohandel,M Soltani
The present study develops a numerical model, which is the most complex one, in comparison to previous research to investigate drug delivery accompanied by the anti-angiogenesis effect. This paper simulates intravascular blood flow and interstitial fluid flow using a dynamic model. The model accounts for the non-Newtonian behavior of blood and incorporates the adaptation of the diameter of a heterogeneous
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From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention. Cancers (IF 5.2) Pub Date : 2023-11-17 Benedetta Maria Motta,Mario Masarone,Pietro Torre,Marcello Persico
Non-alcoholic fatty liver disease (NAFLD) affects up to a quarter of the adult population in many developed and developing countries. This spectrum of liver disease ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) and cirrhosis. The incidence of NASH is projected to increase by up to 56% over the next 10 years. There is growing epidemiological evidence that NAFLD has become the
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Dual-Level Augmentation Radiomics Analysis for Multisequence MRI Meningioma Grading. Cancers (IF 5.2) Pub Date : 2023-11-17 Zongyou Cai,Lun M Wong,Ye Heng Wong,Hok-Lam Lee,Kam-Yau Li,Tiffany Y So
BACKGROUND Preoperative, noninvasive prediction of meningioma grade is important for therapeutic planning and decision making. In this study, we propose a dual-level augmentation strategy incorporating image-level augmentation (IA) and feature-level augmentation (FA) to tackle class imbalance and improve the predictive performance of radiomics for meningioma grading on Magnetic Resonance Imaging (MRI)
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The Diversity of Liquid Biopsies and Their Potential in Breast Cancer Management. Cancers (IF 5.2) Pub Date : 2023-11-17 Corinna Keup,Rainer Kimmig,Sabine Kasimir-Bauer
Analyzing blood as a so-called liquid biopsy in breast cancer (BC) patients has the potential to adapt therapy management. Circulating tumor cells (CTCs), extracellular vesicles (EVs), cell-free DNA (cfDNA) and other blood components mirror the tumoral heterogeneity and could support a range of clinical decisions. Multi-cancer early detection tests utilizing blood are advancing but are not part of
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A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland. Cancers (IF 5.2) Pub Date : 2023-11-17 Pietro De Luca,Arianna Di Stadio,Luca de Campora,Egidio De Bonis,Matteo Fermi,Gerardo Petruzzi,Francesca Atturo,Roberta Colangeli,Alfonso Scarpa,Alfredo Lo Manto,Andrea Colizza,Giulia Cintoli,Giulia Togo,Giovanni Salzano,Domenico Crescenzi,Massimo Ralli,Vincenzo Abbate,Filippo Ricciardiello,Luciano Magaldi,Aurelio D'Ecclesia,Gianluca di Massa,Leopoldo Costarelli,Elisabetta Merenda,Alessandro Corsi
BACKGROUND The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, a subgroup of this tumor presents an aggressive behavior with a tendency to recur. The aim of this multicenter study was to identify and stratify those patients with AciCC at high risk of tumor recurrence. METHODS A retrospective study was carried out involving 77 patients treated with
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The Development and External Validation of Artificial Intelligence-Driven MRI-Based Models to Improve Prediction of Lesion-Specific Extraprostatic Extension in Patients with Prostate Cancer. Cancers (IF 5.2) Pub Date : 2023-11-17 Ingeborg van den Berg,Timo F W Soeterik,Erik J R J van der Hoeven,Bart Claassen,Wyger M Brink,Diederik J H Baas,J P Michiel Sedelaar,Lizette Heine,Jim Tol,Jochem R N van der Voort van Zyp,Cornelis A T van den Berg,Roderick C N van den Bergh,Jean-Paul A van Basten,Harm H E van Melick
Adequate detection of the histopathological extraprostatic extension (EPE) of prostate cancer (PCa) remains a challenge using conventional radiomics on 3 Tesla multiparametric magnetic resonance imaging (3T mpMRI). This study focuses on the assessment of artificial intelligence (AI)-driven models with innovative MRI radiomics in predicting EPE of prostate cancer (PCa) at a lesion-specific level. With
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The m7G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling. Cancers (IF 5.2) Pub Date : 2023-11-17 Jiancong Xie,Taiwei Mo,Ruibing Li,Hao Zhang,Guanzhan Liang,Tao Ma,Jing Chen,Hanlin Xie,Xiaofeng Wen,Tuo Hu,Zhenyu Xian,Weidong Pan
PDAC is one of the most common malignant tumors worldwide. The difficulty of early diagnosis and lack of effective treatment are the main reasons for its poor prognosis. Therefore, it is urgent to identify novel diagnostic and therapeutic targets for PDAC patients. The m7G methylation is a common type of RNA modification that plays a pivotal role in regulating tumor development. However, the correlation
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Current Knowledge about the Peritumoral Microenvironment in Glioblastoma. Cancers (IF 5.2) Pub Date : 2023-11-17 Gianluca Trevisi,Annunziato Mangiola
Glioblastoma is a deadly disease, with a mean overall survival of less than 2 years from diagnosis. Recurrence after gross total surgical resection and adjuvant chemo-radiotherapy almost invariably occurs within the so-called peritumoral brain zone (PBZ). The aim of this narrative review is to summarize the most relevant findings about the biological characteristics of the PBZ currently available in
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Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors. Cancers (IF 5.2) Pub Date : 2023-11-17 Robert T Galvin,Sampreeti Jena,Danielle Maeser,Robert Gruener,R Stephanie Huang
BACKGROUND The application of immunotherapy for pediatric CNS malignancies has been limited by the poorly understood immune landscape in this context. The aim of this study was to uncover the mechanisms of immune suppression common among pediatric brain tumors. METHODS We apply an immunologic clustering algorithm validated by The Cancer Genome Atlas Project to an independent pediatric CNS transcriptomic
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Potential Tumor Suppressor Role of Polo-like Kinase 5 in Cancer. Cancers (IF 5.2) Pub Date : 2023-11-17 Shengqin Su,Mary Ann Ndiaye,Glorimar Guzmán-Pérez,Rebecca Michael Baus,Wei Huang,Manish Suresh Patankar,Nihal Ahmad
The polo-like kinase (PLK) family of serine/threonine kinases contains five members (PLK1-5). Most PLKs are involved in cell cycle regulation and DNA damage response. However, PLK5 is different as it lacks a functional kinase domain and is not involved in cell cycle control. PLK5 remains the least-studied family member, and its role in oncogenesis remains enigmatic. Here, we identified tissues with
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Enhancing Cervical Cancer Prevention in South African Women: Primary HPV mRNA Screening with Different Genotype Combinations. Cancers (IF 5.2) Pub Date : 2023-11-17 Sveinung Wergeland Sørbye,Bente Marie Falang,Matthys H Botha,Leon Cornelius Snyman,Haynes van der Merwe,Cathy Visser,Karin Richter,Greta Dreyer
BACKGROUND Cervical cancer prevention in regions with limited access to screening and HPV vaccination necessitates innovative approaches. This study explored the potential of a test-and-treat strategy using mRNA HPV tests to impact cervical cancer prevention in a high-prevalence HIV population. METHODS A cervical screening study was conducted at three South African hospitals involving 710 under-screened
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Expression of Soluble Form of Aurora A as a Predictive Factor for Neoadjuvant Therapy in Breast Cancer Patients: A Single-Center Pilot Study. Cancers (IF 5.2) Pub Date : 2023-11-16 Pawel Winter,Malgorzata Fuksiewicz,Agnieszka Jagiello-Gruszfeld,Zbigniew Nowecki,Beata Kotowicz
PURPOSE To search for new predictive breast cancer biomarkers. We analyzed the serum concentrations of biomarkers involved in carcinogenesis, which can also be targeted by therapy. METHODS In a single-center prospective study, the serum levels of Aurora A, thymidine kinase 1, and human epidermal growth factor receptor type 3 (HER3) were determined in 119 women with BC before neoadjuvant treatment using
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Primary Tumor Resection in Synchronous Metastatic Colorectal Cancer Patients Treated with Upfront Chemotherapy plus Bevacizumab: A Pooled Analysis of TRIBE and TRIBE2 Studies. Cancers (IF 5.2) Pub Date : 2023-11-16 Valentina Fanotto,Daniele Rossini,Mariaelena Casagrande,Francesca Bergamo,Andrea Spagnoletti,Daniele Santini,Carlotta Antoniotti,Samanta Cupini,Francesca Daniel,Vincenzo Nasca,Guglielmo Vetere,Alberto Zaniboni,Beatrice Borelli,Martina Carullo,Veronica Conca,Alessandro Passardi,Emiliano Tamburini,Gianluca Masi,Nicoletta Pella,Chiara Cremolini
BACKGROUND The decision to resect or not the primary tumor in asymptomatic patients with synchronous metastatic colorectal cancer (mCRC) is a complex and challenging issue for oncologists, especially when an antiangiogenic-based therapy is planned. METHODS Patients enrolled in the phase III TRIBE and TRIBE2 studies that compared upfront FOLFOXIRI + bevacizumab to FOLFIRI or FOLFOX + bevacizumab, respectively
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Arginase-1 in Plasma-Derived Exosomes as Marker of Metastasis in Patients with Head and Neck Squamous Cell Carcinoma. Cancers (IF 5.2) Pub Date : 2023-11-16 Linda Hofmann,Malgorzata Harasymczuk,Diana Huber,Miroslaw J Szczepanski,Grzegorz Dworacki,Theresa L Whiteside,Marie-Nicole Theodoraki
Immunoregulatory Arginase-1 (Arg-1) is present in the tumor microenvironment of solid tumors. Its association to clinicopathology and its prognostic impact are inconsistent among different tumor types and biological fluids. This study evaluated Arg-1 protein levels in tumors and the circulation of patients with head and neck squamous cell carcinoma (HNSCC) in relation to clinical stage and prognosis
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The Use of Natural Language Processing for Computer-Aided Diagnostics and Monitoring of Body Image Perception in Patients with Cancers. Cancers (IF 5.2) Pub Date : 2023-11-16 Elwira Gliwska,Klaudia Barańska,Stella Maćkowska,Agnieszka Różańska,Adrianna Sobol,Dominik Spinczyk
BACKGROUND Head and neck cancers (H&NCs) constitute a significant part of all cancer cases. H&NC patients experience unintentional weight loss, poor nutritional status, or speech disorders. Medical interventions affect appearance and interfere with patients' self-perception of their bodies. Psychological consultations are not affordable due to limited time. METHODS We used NLP to analyze the basic
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Factors Associated with Total Laryngectomy Utilization in Patients with cT4a Laryngeal Cancer. Cancers (IF 5.2) Pub Date : 2023-11-16 Alex R Ritter,Vedat O Yildiz,Nischal Koirala,Sujith Baliga,Emile Gogineni,David J Konieczkowski,John Grecula,Dukagjin M Blakaj,Sachin R Jhawar,Kyle K VanKoevering,Darrion Mitchell
BACKGROUND Despite recommendations for upfront total laryngectomy (TL), many patients with cT4a laryngeal cancer (LC) instead undergo definitive chemoradiation, which is associated with inferior survival. Sociodemographic and oncologic characteristics associated with TL utilization in this population are understudied. METHODS This retrospective cohort study utilized hospital registry data from the
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Novel Metabolic Approaches Targeting Cancer Cells. Cancers (IF 5.2) Pub Date : 2023-11-16 Anna Sebestyén,Michael P Lisanti,Bela Ozsvari
Metabolic reprogramming is one of the main hallmarks of cancer [...].
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Real-World Outcomes of Immunotherapy in Second- or Later-Line Non-Small Cell Lung Cancer with Actionable Genetic Alterations. Cancers (IF 5.2) Pub Date : 2023-11-16 Soojin Jun,Sehhoon Park,Jong-Mu Sun,Se-Hoon Lee,Jin Seok Ahn,Myung-Ju Ahn,Juhee Cho,Hyun Ae Jung
INTRODUCTION While the efficacy of immune checkpoint inhibitors (ICIs) in treating non-small cell lung cancer (NSCLC) patients with actionable genetic alterations (AGAs) is modest, certain patients demonstrate improved survival. Thus, this study aimed to evaluate the benefits of ICIs in NSCLC patients with diverse AGAs and verify the predictive biomarkers of ICI efficacy. METHODS From January 2018
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Determining Optimal Cut-Off Value of Pancreatic-Cancer-Induced Total Cholesterol and Obesity-Related Factors for Developing Exercise Intervention: Big Data Analysis of National Health Insurance Sharing Service Data. Cancers (IF 5.2) Pub Date : 2023-11-16 Hyunseok Jee,Kim Sang Won
This study aimed to examine the effects of multiple parameters on the incidence of pancreatic cancer. We analyzed data from 1,108,369 individuals in the National Health Insurance Sharing Service Database (NHISS DB; birth to death; 2002 to 2015) and identified 2912 patients with pancreatic cancer. Body mass index, systolic/diastolic blood pressure, and fasting blood glucose and total cholesterol concentrations
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Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review. Cancers (IF 5.2) Pub Date : 2023-11-16 Maria Papadoliopoulou,Maria Matiatou,Spyridon Koutsoumpos,Francesk Mulita,Panagiotis Giannios,Ioannis Margaris,Konstantinos Moutzouris,Nikolaos Arkadopoulos,Nikolaos V Michalopoulos
Assessment of regional lymph node status in breast cancer is of important staging and prognostic value. Even though formal histological examination is the currently accepted standard of care, optical imaging techniques have shown promising results in disease diagnosis. In the present article, we review six spectroscopic techniques and focus on their use as alternative tools for breast cancer lymph
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Population-Based External Validation of the EASIX Scores to Predict CAR T-Cell-Related Toxicities. Cancers (IF 5.2) Pub Date : 2023-11-16 Janneke W de Boer,Kylie Keijzer,Elise R A Pennings,Jaap A van Doesum,Anne M Spanjaart,Margot Jak,Pim G N J Mutsaers,Suzanne van Dorp,Joost S P Vermaat,Marjolein W M van der Poel,Lisanne V van Dijk,Marie José Kersten,Anne G H Niezink,Tom van Meerten,
Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can hamper the clinical benefit of CAR T-cell therapy in patients with relapsed/refractory large B-cell lymphoma (r/r LBCL). To assess the risk of CRS and ICANS, the endothelial activation and stress index (EASIX), the modified EASIX (m-EASIX), simplified EASIX (s-EASIX), and EASIX with CRP/ferritin (EASIX-F(C))
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Lung Carcinoids: A Comprehensive Review for Clinicians. Cancers (IF 5.2) Pub Date : 2023-11-16 Dan Granberg,Carl Christofer Juhlin,Henrik Falhammar,Elham Hedayati
Lung carcinoids are neuroendocrine tumors, categorized as typical or atypical carcinoids based on their histological appearance. While most of these tumors are slow-growing neoplasms, they still possess malignant potential. Many patients are diagnosed incidentally on chest X-rays or CT scans. Presenting symptoms include cough, hemoptysis, wheezing, dyspnea, and recurrent pneumonia. Endocrine symptoms
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Ring Chromosomes in Hematological Malignancies Are Associated with TP53 Gene Mutations and Characteristic Copy Number Variants. Cancers (IF 5.2) Pub Date : 2023-11-16 Rachel J Boyd,Jaclyn B Murry,Laura A Morsberger,Melanie Klausner,Suping Chen,Christopher D Gocke,Andrew S McCallion,Ying S Zou
Ring chromosomes (RC) are present in <10% of patients with hematological malignancies and are associated with poor prognosis. Until now, only small cohorts of patients with hematological neoplasms and concomitant RCs have been cytogenetically characterized. Here, we performed a conventional chromosome analysis on metaphase spreads from >13,000 patients diagnosed with hematological malignancies at the
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The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation. Cancers (IF 5.2) Pub Date : 2023-11-16 George Alexandrou,Katerina-Theresa Mantikas,Rebecca Allsopp,Calista Adele Yapeter,Myesha Jahin,Taryn Melnick,Simak Ali,R Charles Coombes,Christofer Toumazou,Jacqueline A Shaw,Melpomeni Kalofonou
Cancer remains a leading cause of death worldwide, despite many advances in diagnosis and treatment. Precision medicine has been a key area of focus, with research providing insights and progress in helping to lower cancer mortality through better patient stratification for therapies and more precise diagnostic techniques. However, unequal access to cancer care is still a global concern, with many
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The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer. Cancers (IF 5.2) Pub Date : 2023-11-16 Hossein Maghsoudi,Farhad Sheikhnia,Przemysław Sitarek,Nooshin Hajmalek,Sepideh Hassani,Vahid Rashidi,Sadaf Khodagholi,Seyed Mostafa Mir,Faezeh Malekinejad,Fatemeh Kheradmand,Mansour Ghorbanpour,Navid Ghasemzadeh,Tomasz Kowalczyk
Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat
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LCMR1 Promotes Large-Cell Lung Cancer Proliferation and Metastasis by Downregulating HLA-Encoding Genes. Cancers (IF 5.2) Pub Date : 2023-11-16 Lu Liu,Chunsun Li,Zhen Wu,Yanqin Li,Hang Yu,Tao Li,Yueming Wang,Wei Zhao,Liangan Chen
Lung cancer is notorious for its high global morbidity and mortality. Here, we examined whether the LCMR1 gene, which we previously cloned from a human large-cell lung carcinoma cell line, contributes to the proliferation and metastasis of large-cell lung carcinoma. To this end, we performed pan-cancer and non-small cell lung cancer (NSCLC) cell line-based LCMR1 expression profiling. Results revealed
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Robotic Stereotactic Radiotherapy for Intracranial Meningiomas-An Opportunity for Radiation Dose De-Escalation. Cancers (IF 5.2) Pub Date : 2023-11-16 Hanna Grzbiela,Elzbieta Nowicka,Marzena Gawkowska,Dorota Tarnawska,Rafal Tarnawski
OBJECTIVE To evaluate the possibility of dose de-escalation, with consideration of the efficacy and safety of robotic stereotactic CyberKnife radiotherapy in patients diagnosed with intracranial meningiomas. METHODS The study group consisted of 172 patients (42 men and 130 women) treated in III Radiotherapy and Chemotherapy Clinic of Maria Sklodowska-Curie National Research Institute of Oncology in
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Machine Learning Model of ResNet50-Ensemble Voting for Malignant-Benign Small Pulmonary Nodule Classification on Computed Tomography Images. Cancers (IF 5.2) Pub Date : 2023-11-15 Weiming Li,Siqi Yu,Runhuang Yang,Yixing Tian,Tianyu Zhu,Haotian Liu,Danyang Jiao,Feng Zhang,Xiangtong Liu,Lixin Tao,Yan Gao,Qiang Li,Jingbo Zhang,Xiuhua Guo
BACKGROUND The early detection of benign and malignant lung tumors enabled patients to diagnose lesions and implement appropriate health measures earlier, dramatically improving lung cancer patients' quality of living. Machine learning methods performed admirably when recognizing small benign and malignant lung nodules. However, exploration and investigation are required to fully leverage the potential
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ASPP2 Is Phosphorylated by CDK1 during Mitosis and Required for Pancreatic Cancer Cell Proliferation. Cancers (IF 5.2) Pub Date : 2023-11-15 Yi Xiao,Yuanhong Chen,Jianan Chen,Jixin Dong
(1) Background: pancreatic cancer is highly lethal. The role of apoptosis-stimulating protein of p53-2 (ASPP2) in this lethal disease remains unclear. This protein belongs to the ASPP family of p53 interacting proteins. Previous studies in this lab used phosphate-binding tag (Phos-tag) sodium dodecyl sulfate (SDS) polyacrylamide gels and identified a motility upshift of the ASPP family of proteins
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Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study. Cancers (IF 5.2) Pub Date : 2023-11-15 Christian Hoffmann,Toke Ringbaek,Anja Eckstein,Wolfgang Deya,Alina Santiago,Martin Heintz,Wolfgang Lübcke,Frank Indenkämpen,Wolfgang Sauerwein,Andrea Flühs,Claudia Le Guin,Andreas Huettmann,Julia von Tresckow,Sophia Göricke,Cornelius Deuschl,Sourour Moliavi,Christoph Poettgen,Thomas Gauler,Nika Guberina,Patricia Johansson,Nikolaos Bechrakis,Martin Stuschke,Maja Guberina
Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients with strictly conjunctival, low-grade
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A Radiomics-Based Machine Learning Perspective on the Parotid Gland as a Potential Surrogate Marker for HPV in Oropharyngeal Cancer. Cancers (IF 5.2) Pub Date : 2023-11-15 Gordian Prasse,Agnes Glaas,Hans-Jonas Meyer,Veit Zebralla,Andreas Dietz,Kathrin Hering,Thomas Kuhnt,Timm Denecke
BACKGROUND In treatment of oropharyngeal squamous cell carcinoma (OPSCC), human papillomavirus status (HPV) plays a crucial role. The HPV-positive subtype tends to affect younger patients and is associated with a more favorable prognosis. HPV-associated lesions have been described in the parotid gland, which is included in routine imaging for OPSCC. This work aims to explore the ability of an ML system