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Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-03-08 Leyu Ai, Na Yi, Chunhan Qiu, Wanyi Huang, Keke Zhang, Qiulian Hou, Long Jia, Hui Li, Ling Liu
Breast cancer arises from the malignant transformation of mammary epithelial cells under the influence of various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become the leading cause of mortality among female malignancies, posing a significant threat to the health of women. The timely identification of breast cancer remains challenging, often resulting in
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Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-03-01 Jinzhe Sun, Shiqian Chen, Dan Zang, Hetian Sun, Yan Sun, Jun Chen
Cancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of
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Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis. Int. J. Oncol. (IF 5.2) Pub Date : 2024-03-01 Bohan Zeng, Runlan Wan, Kun Chang, Jing Li, Xuanzhi Zhang, Guohai Shi, Dingwei Ye, Fujiang Xu
Among all types of renal cancer, clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype and is associated with a high risk of metastasis and recurrence. Histone modifications regulate several biological processes that are fundamental to the development of cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) is an epigenetic modifier responsible for the trimethylation
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Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K‑562 and colorectal HCT‑116 cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2024-03-01 Maria G Kakafika, Areti A Lyta, George I Gavriilidis, Stefanos A Tsiftsoglou, Androulla N Miliotou, Ioannis S Pappas, Ioannis S Vizirianakis, Lefkothea C Papadopoulou, Asterios S Tsiftsoglou
Tumor malignant cells are characterized by dysregulation of mitochondrial bioenergetics due to the 'Warburg effect'. In the present study, this metabolic imbalance was explored as a potential target for novel cancer chemotherapy. Imatinib (IM) downregulates the expression levels of SCΟ2 and FRATAXIN (FXN) genes involved in the heme‑dependent cytochrome c oxidase biosynthesis and assembly pathway in
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Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. Int. J. Oncol. (IF 5.2) Pub Date : 2024-03-01 Regina Wachuka Mbugua, Atsushi Takano, Bayarbat Tsevegjav, Tomoyuki Yokose, Toshinari Yamashita, Yohei Miyagi, Yataro Daigo
Despite advances in treatment and early detection, breast cancer remains one of the most common types of cancer and is the second leading cause of cancer death after lung cancer in women. Therefore, there is an urgent need to develop new biomarkers and therapeutic targets for the treatment of breast cancer. Based on gene expression profiles and subsequent screening performed in a preliminary study
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Immunotherapy targeting PD‑1/PD‑L1: A potential approach for the treatment of cancer bone metastases (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-02-16 Toru Hiraga
Immune checkpoint molecules, such as programmed cell death 1 (PD‑1) and programmed cell death ligand 1 (PD‑L1), have a critical role in regulating immune responses, including in tumor tissues. Monoclonal antibodies against these molecules, known as immune checkpoint inhibitors (ICIs), have been shown to be effective against a variety of cancers; however, significant patient populations are resistant
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GBP2 enhances paclitaxel sensitivity in triple‑negative breast cancer by promoting autophagy in combination with ATG2 and inhibiting the PI3K/AKT/mTOR pathway. Int. J. Oncol. (IF 5.2) Pub Date : 2024-02-09 Weidan Zhang, Xin Tang, Yang Peng, Yingkun Xu, Li Liu, Shengchun Liu
Chemoresistance is a major challenge in treating triple‑negative breast cancer (TNBC); chemotherapy remains the primary approach. The present study aimed to elucidate the role of guanylate‑binding protein 2 (GBP2) in activating autophagy in TNBC and its impact on the sensitivity of TNBC cells to paclitaxel (PTX). Transfection with lentivirus was performed to establish TNBC cell lines with stable, high
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Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification. Int. J. Oncol. (IF 5.2) Pub Date : 2024-02-01 Futaba Inoue, Kenbun Sone, Kohei Kumegawa, Ryuta Hachijo, Eri Suzuki, Saki Tanimoto, Natsumi Tsuboyama, Kosuke Kato, Yusuke Toyohara, Yu Takahashi, Misako Kusakabe, Asako Kukita, Harunori Honjoh, Akira Nishijima, Ayumi Taguchi, Yuichiro Miyamoto, Michihiro Tanikawa, Takayuki Iriyama, Mayuyo Mori, Osamu Wada-Hiraike, Katsutoshi Oda, Hiromu Suzuki, Reo Maruyama, Yutaka Osuga
Histone modification, a major epigenetic mechanism regulating gene expression through chromatin remodeling, introduces dynamic changes in chromatin architecture. Protein arginine methyltransferase 6 (PRMT6) is overexpressed in various types of cancer, including prostate, lung and endometrial cancer (EC). Epigenome regulates the expression of endogenous retrovirus (ERV), which activates interferon signaling
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Role and research progress of spasmolytic polypeptide‑expressing metaplasia in gastric cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-02-01 Yang Chong, Dong Yu, Zhaoyu Lu, Fengsong Nie
Gastric cancer ranks as one of the most prevalent cancers worldwide. While the incidence of gastric cancer in Western countries has notably diminished over the past century, it continues to be a leading cause of cancer‑related mortality on a global scale. The majority of gastric cancers in humans are attributed to chronic Helicobacter pylori infection and the progression of gastric cancer is often
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Advances in the role of GPX3 in ovarian cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-02-01 Danbo Geng, Yingying Zhou, Min Wang
Ovarian cancer (OC) is the 5th most common malignancy in women, and the leading cause of death from gynecologic malignancies. Owing to tumor heterogeneity, lack of reliable early diagnostic methods and high incidence of chemotherapy resistance, the 5‑year survival rate of patients with advanced OC remains low despite considerable advances in detection and therapeutic approaches. Therefore, identifying
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UBDP1 pseudogene and UBD network competitively bind miR‑6072 to promote glioma progression. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-26 Fan Hong, Zhenyu Gong, Chao Chen, Tianzhen Hua, Qilin Huang, Yu'e Liu, Peipei Ma, Xu Zhang, Hongxiang Wang, Juxiang Chen
Increasing evidence suggests that pseudogenes play crucial roles in various cancers, yet their functions and regulatory mechanisms in glioma pathogenesis remain enigmatic. In the present study, a novel pseudogene was identified, UBDP1, which is significantly upregulated in glioblastoma and positively correlated with the expression of its parent gene, UBD. Additionally, high levels of these paired genes
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SLCO4A1, as a novel prognostic biomarker of non‑small cell lung cancer, promotes cell proliferation and migration. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-26 Shihao Li, Zihao Li, Lan Huang, Zhenyang Geng, Feng Li, Bin Wu, Yinliang Sheng, Yifan Xu, Bowen Li, Yiming Xu, Zhuoyu Gu, Yu Qi
Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is a membrane transporter protein. The role of this molecule in non‑small cell lung cancer (NSCLC) remains unclear. Bulk sequencing was carried out using early‑stage NSCLC tissues with lymph node metastasis to identify SLCO4A1 that influences NSCLC cell proliferation, metastasis and prognosis. The in vitro functional assays carried
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Altered histone acetylation patterns in pancreatic cancer cell lines induce subtype‑specific transcriptomic and phenotypical changes. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-19 Quan Zhou, Svenja Pichlmeier, Anna Maria Denz, Nicole Schreiner, Tobias Straub, Simone Benitz, Julia Wolff, Lisa Fahr, Maria Del Socorro Escobar Lopez, Jörg Kleeff, Julia Mayerle, Ujjwal Mukund Mahajan, Ivonne Regel
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at advanced tumor stages with chemotherapy as the only treatment option. Transcriptomic analysis has defined a classical and basal‑like PDAC subtype, which are regulated by epigenetic modification. The present study aimed to determine if drug‑induced epigenetic reprogramming of pancreatic cancer cells affects PDAC subtype identity and chemosensitivity
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Exosome as a crucial communicator between tumor microenvironment and gastric cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-19 Menghui Wang, Hongxin Shu, Xifu Cheng, Hong Xiao, Zhenhua Jin, Nan Yao, Shengxun Mao, Zhen Zong
Gastric cancer is one of the most common malignancies and has relatively high morbidity and mortality rates. Exosomes are nanoscale extracellular vesicles that originate from a diverse array of cells and may be found throughout various bodily fluids. These vesicles are endogenous nanocarriers in their natural state with the unique ability to transport lipids, proteins, DNA and RNA. Exosomes contain
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The emerging roles of CEACAM6 in human cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-19 Guanhua Wu, Da Wang, Fei Xiong, Qi Wang, Wenzheng Liu, Junsheng Chen, Yongjun Chen
Carcinoembryonic antigen (CEA)‑related cell adhesion molecule 6 (CEACAM6) is a cell adhesion protein of the CEA family of glycosyl phosphatidyl inositol anchored cell surface glycoproteins. A wealth of research has demonstrated that CEACAM6 is generally upregulated in pancreatic adenocarcinoma, breast cancer, non‑small cell lung cancer, gastric cancer, colon cancer and other cancers and promotes tumor
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Targeting endogenous fatty acid synthesis stimulates the migration of ovarian cancer cells to adipocytes and promotes the transport of fatty acids from adipocytes to cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-12 Thomas W Grunt, Renate Wagner, Alexander Ries, Anna S Berghoff, Matthias Preusser, Michael Grusch, Peter Valent
Despite significant advances in oncology, 1 of 108 female patients succumb to ovarian cancer (OC) each year. Improved novel treatments against this aggressive disease would be a major improvement. The growth of OC cells has been demonstrated to be highly dependent on lipids. OC cells are abundantly present in the abdominal cavity and omentum, the main sites of OC expansion. Accordingly, it has been
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HDAC inhibitors target IRS4 to enhance anti‑AR therapy in AR‑positive triple‑negative breast cancer. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-12 Yang He, Yue Ma, Ye Zhu, Jingyi Zhang, Shaorong Zhao, Di Zhang, Danni Xu, Yun Li, Zhongsheng Tong, Weipeng Zhao
Triple‑negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Androgen receptor (AR) has been identified as a potential therapeutic target for AR‑positive TNBC; however, clinical trials have not yet produced an effective treatment. The present study aimed to identify a novel treatment regimen to improve the prognosis of AR‑positive TNBC. First, a combination of an AR inhibitor
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Advances in the study of antisense long‑stranded non‑coding RNAs in tumors (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-12 Yifan Shao, Yuwei Dong, Jing Zhou, Zhihua Lu, Chen Chen, Xiaomin Yuan, Linhai He, Wenwen Tang, Zepeng Chen, Yuji Wang, Qiurong Li, Shuhui Zhan, Zhengxi Qiu, Kuiling Wang, Jiaze Ma, Yugen Chen, Yang Li
Long‑stranded non‑coding RNAs (lncRNAs) are RNAs that consist of >200 nucleotides. The majority of lncRNAs do not encode proteins but have been revealed to mediate a variety of important physiological functions. Antisense‑lncRNAs (AS‑lncRNAs) are transcribed from the opposite strand of a protein or non‑protein coding gene as part of the antisense strand of the coding gene. AS‑lncRNAs can serve an important
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[Corrigendum] Long non‑coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway. Int. J. Oncol. (IF 5.2) Pub Date : 2024-01-12 Zhuo Li, Dehai Yu, Haijun Li, You Lv, Sijie Li
Subsequently to the publication of the above article, an interested reader drew to the authors' attention what appeared to be a factual error associated with the reported primer sequences for the p21 promoter. The authors have re‑examined their paper carefully, and wish to make the following textual corrections in light of the query raised by the reader. The first errors were located on p. 1033 and
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FABP5 can substitute for androgen receptor in malignant progression of prostate cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-22 Abdulghani A Naeem, Saud A Abdulsamad, Hao Zeng, Gang He, Xi Jin, Jiacheng Zhang, Bandar T Alenezi, Hongwen Ma, Philip S Rudland, Youqiang Ke
Fatty acid‑binding protein 5 (FABP5) and androgen receptor (AR) are critical promoters of prostate cancer. In the present study, the effects of knocking out the FABP5 or AR genes on malignant characteristics of prostate cancer cells were investigated, and changes in the expression of certain key proteins in the FABP5 (or AR)‑peroxisome proliferator activated receptor‑γ (PPARγ)‑vascular endothelial
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Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-22 Chiyun Shao, Yanjie Han, Yuying Huang, Zhe Zhang, Tao Gong, Yajie Zhang, Xiaokang Tian, Mingzhi Fang, Xuan Han, Min Li
RNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6‑methyladenosine (m6A) methyltransferases
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Long non‑coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-15 Yingjie He, Xuezhi Du, Fan Yuan, Caigu Yan, Ming Chen, Lei Han, Jinjin Sun
Due to the lack of specific symptoms, characteristic diagnostic markers and effective comprehensive treatment, gallbladder cancer (GBC) is currently considered one of the most malignant abdominal tumors. With the rapid development of biological technologies, long non‑coding RNAs (lncRNAs), once regarded as transcriptional junk, have been demonstrated to participate in almost the whole process of the
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[Retracted] Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-15 Qingping Guo, Jiale Wang, Zeyu Cao, Yongchang Tang, Chao Feng, Feizhou Huang
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the western blotting data shown in Figs. 2B and 3E were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to International
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Research progress on the role of tumor‑associated macrophages in tumor development and their use as molecular targets (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Chenglin Lu, Ying Liu, Linxuan Miao, Xiangle Kong, Huili Li, Haoran Chen, Xu Zhao, Bin Zhang, Xiaonan Cui
The tumor microenvironment (TME) is a complex system composed mainly of tumor cells, mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated macrophages (TAMs), among innate immune cells, are some of the most abundant components of the TME. They may influence tumor growth and metastasis through interactions with other cell populations in the TME and have been associated with
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The dual HDAC and PI3K inhibitor, CUDC‑907, inhibits tumor growth and stem‑like properties by suppressing PTX3 in neuroblastoma. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Mengzhen Li, Yang Hu, Juan Wang, Yanjie Xu, Ye Hong, Li Zhang, Qiuyun Luo, Zijun Zhen, Suying Lu, Junting Huang, Jia Zhu, Yizhuo Zhang, Yi Que, Feifei Sun
Neuroblastoma (NB) is one of the common solid tumors in childhood and poses a threat to the lives of children. Patients with advanced‑stage or recurrent NB have a poor prognosis. CUDC‑907, as a novel dual‑target inhibitor of histone deacetylase (HDAC) and phosphatidylinositol‑3‑kinase (PI3K), has been proven to play an antitumor role in several types of tumors. However, the exact role of CUDC‑907 in
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m6A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Yujuan Zhou, Qiang Huang, Chunping Wu, Ye Xu, Yang Guo, Xiaohui Yuan, Chengzhi Xu, Liang Zhou
The homeobox (HOX) gene family plays a fundamental role in carcinogenesis. However, the oncogenic mechanism of HOXC10 in head and neck squamous cell carcinoma (HNSCC) remains unclear. In the present study, it was revealed that HOXC10 expression was significantly higher in HNSCC tissues than in adjacent tissues, and a high level of HOXC10 was closely associated with worse clinical outcomes. HOXC10 overexpression
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Differential impact of cytoplasmic vs. nuclear RAD51 expression on breast cancer progression and patient prognosis. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Yen-Yun Wang, Kuang-Hung Cheng, Amos C Hung, Steven Lo, Pang-Yu Chen, Yi-Chia Wu, Ming-Feng Hou, Shyng-Shiou F Yuan
RAD51 recombinase is one of the DNA damage repair proteins associated with breast cancer risk. Apart from its function to maintain genomic integrity within the cell nucleus, RAD51 localized to the cytoplasm has also been implicated in breast malignancy. However, limited information exists on the roles of cytoplasmic vs. nuclear RAD51 in breast cancer progression and patient prognosis. In the present
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Dual‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Hua Liu, Min Li, Yanlan Lin, Huining You, Jianrong Kou, Weiyi Feng
Metronomic chemotherapy (MCT) regimens may be associated with risks to the patient due to the ambiguity surrounding low dosages and schedules. In the present study, metronomic regimens of vinorelbine (NVB) combined with cisplatin (CDDP) or fluorouracil (5‑FU) were chosen to study the dose‑response associations with tumor growth and metastasis, along with the underlying mechanisms in angiogenesis, apoptosis
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[Retracted] Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-08 Xuan Zhou, Yu Ren, Lei Han, Mei Mei, Peng Xu, Chun-Zhi Zhang, Guang-Xiu Wang, Zhi-Fan Jia, Pei-Yu Pu, Chun-Sheng Kang
Following the publication of the above article, a concerned reader drew to the Editor's attention that, regarding the western blots featured in Fig. 3B on p. 670, the bands featured in the U251 and U251‑MC lanes for the miR‑21 and U6 experiments appeared to be duplicates of each other. Moreover, certain of these data were strikingly similar to data that appeared in another article published at around
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Function of microRNA‑124 in the pathogenesis of cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-01 Yuchen Liu,Yipin Yang,Xinyi Wang,Siyue Yin,Bingyu Liang,Yuchen Zhang,Min Fan,Ziyue Fu,Chuanlu Shen,Yanxun Han,Bangjie Chen,Qian Zhang
Non‑coding RNAs with a length of 22‑24 nt are known as microRNAs (miRNAs or miRs), which are critical regulators of protein translation. Over the past 10 years, the roles of miRNAs have been extensively investigated in several human cancer types. There is evidence to indicate that miRNAs regulate gene expression by concentrating on a number of substances that have an impact on the physiology and development
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CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis. Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-01 Yuting Zheng,Shaojie Yang,Wanlin Dai,Jingnan Wang,Shiyuan Bi,Xiaolin Zhang,Zhuyuan Zheng,Yang Sun,Shuodong Wu,Jing Kong
Charged multivesicular body protein 3 (CHMP3) is an elemental constituent of the endosomal sorting complex required for transport (ESCRT) III, whose function as a tumor susceptibility gene in the development of liver cancer remains unclear. CHMP3 was found to be associated with pyroptosis by bioinformatics analysis of data from patients with hepatocellular carcinoma (HCC) in The Cancer Genome Atlas
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Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-12-01 Monica Cantile,Margherita Cerrone,Maurizio Di Bonito,Pasquale Moccia,Maura Tracey,Gerardo Ferrara,Alfredo Budillon
Nuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated
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Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-24 Ranjith Kumavath, Honey Pavithran, Sayan Paul, V T Anju, Siddhardha Busi, Madhu Dyavaiah
Cancer is one of the leading causes of death worldwide and it is estimated that the mortality rate of cancer will increase in the coming years. The etiology of the development and progression of cancer is multifactorial. Insights have been gained on the association between the human microbiome and tumor cell malignancy. A number of commensal microbe species are present in the human gut. They serve
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[Corrigendum] Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-24 Shuang Zhao, Lisha Wu, Yehong Kuang, Juan Su, Zhongling Luo, Yan Wang, Jinmao Li, Jianglin Zhang, Wangqing Chen, Fangfang Li, Yijing He, Juan Tao, Jianda Zhou, Xiaowei Xu, Cong Peng, Xiang Chen
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that the β‑actin bands shown for the western blots portrayed in Fig. 4A and E on p. 2403 appeared to be strikingly similar, albeit that the bands were inverted with respect to their orientation and the dimensions of the bands differed slightly. After re‑examining their original data, the authors
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Prolyl hydroxylase 2 inhibits glycolytic activity in colorectal cancer via the NF‑κB signaling pathway. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-17 Lisha Xiang, Hao Wei, Wentao Ye, Shuang Wu, Ganfeng Xie
A variety of malignancies preferentially meet energy demands through the glycolytic pathway. Hypoxia‑induced cancer cell adaptations are essential for tumor development. However, in cancerous glycolysis, the functional importance and underlying molecular mechanism of prolyl hydroxylase domain protein 2 (PHD2) have not been fully elucidated. Gain‑ and loss‑of‑function assays were conducted to evaluate
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Endoplasmic reticulum regulation of glucose metabolism in glioma stem cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-08 María Turos-Cabal, Ana M Sánchez-Sánchez, Noelia Puente-Moncada, Federico Herrera, Jezabel Rodriguez-Blanco, Isaac Antolin, Marco Antonio Alvarez-Vega, Carmen Rodríguez, Vanesa Martín
Glioblastoma (GBM) treatment is extremely challenging due to the high complexity of the tumor. It is one of the tumors in which a subpopulation of highly resistant glioma initiating cells (GICs) has been clearly identified. Thus, understanding the differences between GICs and tumor bulk cells is therefore essential to move to less conventional but more efficient approaches. It was found that, unlike
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The apelin‑apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-03 Hirotsugu Saiki,Yoshito Hayashi,Shunsuke Yoshii,Eiji Kimura,Kentaro Nakagawa,Minoru Kato,Ryotaro Uema,Takanori Inoue,Akihiko Sakatani,Takeo Yoshihara,Yoshiki Tsujii,Shinichiro Shinzaki,Hideki Iijima,Tetsuo Takehara
Cancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. TP53‑deficiency in cancer cells is associated with robust stromal activation. The apelin‑apelin receptor (APJ) system has been implicated in suppressing fibroblast‑to‑myofibroblast transition in non‑neoplastic organ fibrosis. The present study aimed to elucidate the oncogenic role of the apelin‑APJ system in tumor fibroblasts. APJ
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MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de‑methylases. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-03 Zhuanzhen Zheng,Xiuhua Chen,Yaofang Zhang,Fanggang Ren,Yanping Ma
The transformation of myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) poses a significant clinical challenge. The trimethylation of H3 on lysine 27 (H3K27me3) methylase and de‑methylase pathway is involved in the regulation of MDS progression. The present study investigated the functional mechanisms of the MEK/ERK and PI3K/AKT pathways in the MDS‑to‑AML transformation. MDS‑AML mouse
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Knockdown of lncRNA MALAT1 induces pyroptosis by regulating the miR‑124/SIRT1 axis in cervical cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-11-03 Tian Liang,Tong Lu,Weiwei Jia,Runze Li,Min Jiang,Yu Jiao,Yuchen Wang,Shanshan Cong,Xinyan Jiang,Lina Dong,Yingyu Zhou,Guangmei Zhang,Dan Xiao
The aim of the present study was to elucidate the role and downstream mechanism of long non‑coding RNA (lncRNA) metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) in the process of cervical cancer cell pyroptosis. The effect of inhibiting lncRNA MALAT1 on cervical cancer cells was determined using primary cells isolated from patients and U14 cervical tumor‑bearing nude mice. The level
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Tumor immune microenvironment and the current immunotherapy of cholangiocarcinoma (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-27 Siqi Yang, Ruiqi Zou, Yushi Dai, Yafei Hu, Fuyu Li, Haijie Hu
Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy originating from the epithelial system of the bile ducts, and its incidence in recent years is steadily increasing. The immune microenvironment of CCA is characterized by diversity and complexity, with a substantial presence of cancer‑associated fibroblasts and immune cell infiltration, which plays a key role in regulating the distinctive
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Acidosis promotes the metastatic colonization of lung cancer via remodeling of the extracellular matrix and vasculogenic mimicry. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-27 Wan-Yi Shie, Pin-Hsuan Chu, Mark Yen-Ping Kuo, Huei-Wen Chen, Meng-Tie Lin, Xuan-Jie Su, Yi-Ling Hong, Han-Yi Elizabeth Chou
Acidosis is a hallmark of the tumor microenvironment caused by the metabolic switch from glucose oxidative phosphorylation to glycolysis. It has been associated with tumor growth and progression; however, the precise mechanism governing how acidosis promotes metastatic dissemination has yet to be elucidated. In the present study, a long‑term acidosis model was established using patient‑derived lung
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[Corrigendum] Fully human VEGFR2 monoclonal antibody BC001 attenuates tumor angiogenesis and inhibits tumor growth. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-27 Zi-Xue Xuan, Lin-Na Li, Qi Zhang, Cheng-Wang Xu, De-Xuan Yang, Ye Yuan, Ying-Hong An, Shan-Shan Wang, Xiao-Wen Li, Shou-Jun Yuan
Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, for the scratch wound assay experiments shown in Fig. 1 on p. 2413, the panels showing the '0 h' experiments for the respective incubations with VEGF or BC001 were apparently identical. The authors were able to re‑examine their original data files, and realized that this figure had been inadverently
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Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-27 Xu Wang, Yanan Qu, Ruonan Xing, Jing Zhou, Yanghe Liu, Huishu Zhang, Jing Zhu, Jinfa Ma, Xiaobo Cui, Tiantian Song, Shukai Xing, Guohua Ji, Peng Liu, Wenjing Sun, Songbin Fu, Xiangning Meng
Extrachromosomal DNAs (ecDNAs), also known as double minutes (DMs), can induce a fast increase in gene copy numbers and promote the development of cancer, including drug resistance. MutS homolog 3 (MSH3), a key protein in mismatch repair, has been indicated to participate in the regulation of DNA double‑strand break (DSB) repair, which has been reported to be associated with the formation of ecDNAs
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Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-20 Yue Qi,Ningye Ma,Jin Zhang
Tripartite motif containing 33 (TRIM33) has been reported to be involved in various tumor progression. However, its role in endometrial carcinoma (EC) remains to be elucidated. By mining the publicly available databases UALCAN and TIMER, low expression of TRIM33 was found in tumor tissues of EC patients. Clinically, downregulation of TRIM33 in EC tissues was positively correlated with the extensive
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Journey of CAR T‑cells: Emphasising the concepts and advancements in breast cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-13 Mohd Adnan Kausar, Sadaf Anwar, Hemat El-Sayed El-Horany, Farida Habib Khan, Neetu Tyagi, Mohammad Zeeshan Najm, Sadaf, Alaa Abdulaziz Eisa, Chandrajeet Dhara, Saumyatika Gantayat
Cancer is the primary and one of the most prominent causes of the rising global mortality rate, accounting for nearly 10 million deaths annually. Specific methods have been devised to cure cancerous tumours. Effective therapeutic approaches must be developed, both at the cellular and genetic level. Immunotherapy offers promising results by providing sustained remission to patients with refractory malignancies
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CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-13 Zhenxing Wang, Lanxin Li, Chunhong Chu, Xiangkai Wei, Qian Liu, Rui Wang, Guoliang Zhang, Guangyao Wu, Ying Wang, Lei An, Xiaodong Li
Bladder cancer is one of the most common urological malignancies worldwide. The molecular mechanism underlying its development is complex, but its carcinogenesis has been proposed to occur with cell proliferation and resistance to apoptosis, driven by the signaling activity of abundant EGFR and receptor tyrosine‑protein kinase erbB‑2. In the present study, T24 bladder cancer cell lines with EGFR‑overexpression
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Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-06 Yoon Soo Chang, Joell J Gills, Shigeru Kawabata, Masahiro Onozawa, Giusy Della Gatta, Adolfo A Ferrando, Peter D Aplan, Phillip A Dennis
T cell acute lymphoblastic leukemia (T‑ALL), a neoplasm derived from T cell lineage‑committed lymphoblasts, is characterized by genetic alterations that result in activation of oncogenic transcription factors and the NOTCH1 pathway activation. The NOTCH is a transmembrane receptor protein activated by γ‑secretase. γ‑secretase inhibitors (GSIs) are a NOTCH‑targeted therapy for T‑ALL. However, their
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[Retracted] Expression and function of PIM kinases in osteosarcoma. Int. J. Oncol. (IF 5.2) Pub Date : 2023-10-06 Shuai Mou, Guangbin Wang, Ding Ding, Dongdong Yu, Yi Pei, Songling Teng, Qin Fu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that (in addition to overlapping data panels internally within the figure, suggesting that some of the data had been derived from the same original sources where the results of differently performed experiments were intended to have been portrayed) certain of the data featured in Fig. 5A on p. 2123
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Emerging proteins involved in castration‑resistant prostate cancer via the AR‑dependent and AR‑independent pathways (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-21 Kangle Feng,Chunhua Liu,Weixi Wang,Piaoping Kong,Zhihua Tao,Weiwei Liu
Despite achieving optimal initial responses to androgen deprivation therapy, most patients with prostate cancer eventually progress to a poor prognosis state known as castration‑resistant prostate cancer (CRPC). Currently, there is a notable absence of reliable early warning biomarkers and effective treatment strategies for these patients. Although androgen receptor (AR)‑independent pathways have been
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Calcium signals and potential therapy targets in ovarian cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-15 Fengying Deng,Mengyu Fu,Chenxuan Zhao,Jiahui Lei,Ting Xu,Bingyu Ji,Hongmei Ding,Yueming Zhang,Jie Chen,Junlan Qiu,Qinqin Gao
Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption
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Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-15 Weiqiong Zhang,Ruiping Zhou,Xin Liu,Lin You,Chang Chen,Xiaoling Ye,Jie Liu,Youde Liang
Cancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth
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Role of stress in the pathogenesis of cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-15 Ioannis G Lempesis,Vasiliki Epameinondas Georgakopoulou,Petros Papalexis,Georgios P Chrousos,Demetrios A Spandidos
Stress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on
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Circular RNAs in osteosarcoma: An update of recent studies (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-08 Le Zeng, Longzhou Liu, Wen-Juan Ni, Fuhua Xie, Xiao-Min Leng
Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs
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Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer. Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-08 Qi Sun, Boxin Liu, Quanxue Lan, Zijie Su, Qiuxia Fu, Lian Wang, Yingying Deng, Chuanli Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guowu Yang, Desheng Lu
Chloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated
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Anti‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-08 Xiao Hu, Jin Ren, Qianfei Xue, Rumei Luan, Dongyan Ding, Jie Tan, Xin Su, Junling Yang
Immune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting
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Mechanism of multidrug resistance to chemotherapy mediated by P‑glycoprotein (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-01 Yichen Tian, Yongrong Lei, Yani Wang, Jiejuan Lai, Jianhua Wang, Feng Xia
Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs. P‑glycoprotein (P‑gp) is an ATP‑binding cassette (ABC) transporter, which promotes MDR by pumping out chemotherapeutic drugs and reducing their intracellular concentration. To date, overexpression of P‑gp
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CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia‑induced invasion and therapeutic resistance. Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-01 Jan C Lumibao, Payton L Haak, Vladimir L Kolossov, Jee-Wei Emily Chen, Jeremy Stutchman, Alejandra Ruiz, Mayandi Sivaguru, Jann N Sarkaria, Brendan A C Harley, Andrew J Steelman, H Rex Gaskins
Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2
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Human cytomegalovirus infection enhances 5‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer. Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-01 Mattia Russel Pantalone, Nerea Martin Almazan, Rossano Lattanzio, Chato Taher, Simone De Fabritiis, Silvia Valentinuzzi, Faraz Bishehsari, Mahboobeh Mahdavinia, Fabio Verginelli, Afsar Rahbar, Renato Mariani-Costantini, Cecilia Söderberg-Naucler
Colorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation promotes CRC development, however, the underlying etiological factors are unknown. Human cytomegalovirus (HCMV), a virus that induces inflammation and other cancer hallmarks, has been detected in several types of malignancy, including CRC. The present study investigated whether HCMV infection was associated with
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RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity. Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-01 Takashi Morinaka, Nozomu Sakai, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Gaku Ohira, Hisahiro Matsubara, Masayuki Ohtsuka
Ring1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 and serves as a transcriptional suppressor via epigenetic modification. RYBP has a tumour‑suppressive role in solid tumours, but its function in colorectal cancer (CRC) remains unknown. The present study evaluated the expression of RYBP using immunohistochemistry in 140 cases of primary CRC and 11 patient‑matched
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Roles of salt‑inducible kinases in cancer (Review). Int. J. Oncol. (IF 5.2) Pub Date : 2023-09-01 Shenghui Feng, Fangyi Wei, Haoran Shi, Shen Chen, Bangqi Wang, Deqiang Huang, Lingyu Luo
Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates