-
Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-08 Zhongbao Zhang, Beibei Sun, Jinqiu Lu, Penglai Bai, Yu Su, Yanchun Li
The antitumor effect of norcantharidin (NCTD) has been widely reported. However, whether NCTD can inhibit cervical cancer remains unknown. In the present study, it was shown that NCTD inhibited the viability of cervical cancer cells and caused cell cycle arrest in a concentration‑dependent manner. Further analysis revealed that the NCTD‑induced reduction in cell viability could be reversed by the inhibitor
-
[Corrigendum] Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-08 Lu Jin, Jing Quan, Xiang Pan, Tao He, Jia Hu, Yifan Li, Yaoting Gui, Shangqi Yang, Xiangming Mao, Yun Chen, Yongqing Lai
Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerrning the Transwell cell migration and invasion assay data shown in Fig. 6A and B for the 786‑O cell line on p. 7206, the pcDNA3.1‑EGOT 'Migration' and 'Invasion' (a‑1 and b‑1) data panels appeared to contain overlapping sections of data, such that they were potentially derived from the
-
Bif‑1 inhibits activation of inflammasome through autophagy regulatory mechanism. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-08 Yuehui Zhang, Wenhui Su, Yaoyun Niu, Hongli Zeng, Lu Liu, Lijun Wang, Weidong Xie
Inflammasome activation is a crucial mechanism in inflammatory responses. Bax‑interacting factor 1 (Bif‑1) is required for the normal formation of autophagosomes, but its ability to exert an inflammatory regulatory effect remains unclear. The aim of the present study was to explore the role of Bif‑1 in inflammation, possibly mediated through autophagy regulation. Using a lipopolysaccharide (LPS)/adenosine
-
[Retracted] Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-08 Huiying Qiao, Haiyan Ren, He Du, Minfang Zhang, Xiaofang Xiong, Rong Lv
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the immunofluorescence data shown in Fig. 2G, the mitochondria‑ and lysosome‑stained images in Fig. 3C, the JC‑1 staining images in Fig. 4C and the immunofluorescence data in Fig. 5G were strikingly similar to data appearing in different form in other articles written by different authors at different
-
RICH1 is a novel key suppressor of isoproterenol‑ or angiotensin II‑induced cardiomyocyte hypertrophy. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-08 Siqi Wang, Xin Wang, Li Ling, Cairong Li, Zhanhong Ren
Cardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge
-
SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt/β‑catenin pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-01 Ruihong Lan, Yihong Yu, Jie Song, Mengdi Xue, Humin Gong
The present study investigates the role of Secreted Frizzled‑Related Protein 2 (SFRP2) in trophoblast cells, a key factor in preeclampsia (PE) progression. Elevated levels of Secreted Frizzled‑Related Protein 1/3/4/5 (SFRP1/3/4/5) are associated with PE, but the role of SFRP2 is unclear. We analyzed SFRP2 expression in PE placental tissue using the GSE10588 dataset and overexpressed SFRP2 in JEG‑3
-
[Retracted] Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-01 Chen Li, Zhenfan Wang, Ninghan Feng, Jian Dong, Xiaoyan Deng, Yin Yue, Yuehong Guo, Jianquan Hou
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the cellular morphological data in Fig. 1C, the immunofluorescence data shown in Fig. 1E, and certain of the scratch‑wound assay data shown in Fig. 2A were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that
-
SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF‑1α signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-01 Zhe Qing, Qun Luo, Jian Duan, Jie Lin, Hanfei Huang, Shikun Yang, Zhong Zeng
Liver sinusoidal endothelial cells (LSECs) have an important role in hepatic ischemia‑reperfusion injury (I/R), but the specific molecular mechanism of action is unknown. LSEC proliferation is regulated and fenestration is maintained via the Sentrin/SUMO‑specific protease 1 (SENP1)/hypoxia‑inducible factor‑1α (HIF‑1α) signaling axis under hypoxic conditions. In the present study, a hypoxia‑reoxygenation
-
[Corrigendum] Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-03-01 Hong-Gang Qian, Qiong Wu, Jian-Hui Wu, Xiu-Yun Tian, Wei Xu, Chun-Yi Hao
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of data panels featured in Figs. 2E and 6D, portraying the results from cell invasion and migration assay experiments, appeared to contain overlapping sections, such that data which were intended to show the results from differently performed experiments had apparently been derived
-
Research advances of MAL family members in tumorigenesis and tumor progression (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-16 Mengyao Li, Yan Du, Xianzhuo Zhang, Wence Zhou
The myelin and lymphocyte protein (MAL) family is a novel gene family first identified and characterized in 2002. This family is comprised of seven members, including MAL, MAL2, plasmolipin, MALL, myeloid differentiation‑associated marker (MYADM), MYADML2 and CMTM8, which are located on different chromosomes. In addition to exhibiting extensive activity during transcytosis, the MAL family plays a vital
-
[Corrigendum] microRNA‑181a‑5p functions as an oncogene in renal cell carcinoma. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-16 Yulin Lai, Liwen Zhao, Jia Hu, Jing Quan, Peijie Chen, Jinling Xu, Xin Guan, Yongqing Lai, Liangchao Ni
Following the publication of the above article and a corrigendum in 2018 that corrected details of the correspondence information for authors, errors made in Fig. 5 and the funding details (doi: 10.3892/mmr.2018.9117), an interested reader drew to the authors' attention that, in Fig. 6 on p. 8515 showing the results of cell migration and invasion assay experiments, a pair of data panels were overlapping
-
Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-09 Amar Alomair, Abdullah Alamri, Jilani Shaik, Salman Aljafari, Mohammed Ba Abdullah, Mohammad Alanazi
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single‑nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the effects of the genetic variants of RAD51 recombinase (RAD51) and 8‑oxoguanine DNA glycosylase (OGG1) on CVD through genotyping and statistical analysis. Regardless
-
Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia‑reperfusion injury in sevoflurane‑treated rats. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-09 Ayşe Hande Arpaci, Zeynep Köksal, Zeynep Yiğman, Ayşegül Küçük, Volkan Şivgin, Mustafa Arslan, Mustafa Kavutçu, Saadet Özen Akarca Di Zakar
The aim of the present study was to examine the effect of fullerenol C60 on lung and kidney tissue in sevoflurane‑treated rats with lower extremity ischemia‑reperfusion (IR) injury. A total of 30 Wistar albino rats weighing 225‑275 g were used and were equally divided into five groups (n=6/group): i) Sham; ii) IR; iii) IR‑fullerenol C60 (IR‑FUL); iv) IR‑sevoflurane; and v) IR‑fullerenol C60‑sevoflurane
-
M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-09 Huiyu Chen, Huafen Liu, Dishiwen Liu, Yuntao Fu, Yajun Yao, Zhen Cao, Zhibin Peng, Mei Yang, Qingyan Zhao
The present study was designed to explore the role of M2 macrophage‑derived exosomes (M2‑exos) on the KCa3.1 channel in a cellular atrial fibrillation (AF) model using rapidly paced HL‑1 myocytes. M2 macrophages and M2‑exos were isolated and identified. MicroRNA (miR)‑146a‑5p levels in M2 macrophages and M2‑exos were quantified using reverse transcription‑quantitative PCR (RT‑qPCR). HL‑1 myocytes were
-
[Retracted] Activation of the LKB1‑SIK1 signaling pathway inhibits the TGF‑β‑mediated epithelial‑mesenchymal transition and apoptosis resistance of ovarian carcinoma cells. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-09 Bo Hong, Jianmei Zhang, Wenlan Yang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion and migration assay data shown in Figs. 2C and 3F were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for
-
Activation of AMPK pathway by low‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-01 Yaowei Bai, Kequan Chen, Jiacheng Liu, Yingliang Wang, Chaoyang Wang, Shuguang Ju, Chen Zhou, Wei Yao, Bin Xiong, Chuansheng Zheng
Metabolic dysfunction‑associated steatotic liver disease (MASLD) is an increasingly significant global health burden for which there is currently no effective treatment. The present study aimed to explore the underlying mechanisms and investigate the effects of donafenib and atorvastatin in MASLD. The effects of donafenib and atorvastatin on the activity and lipid metabolism of HepG2 cells were analyzed
-
[Corrigendum] FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-01 Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zhou
Subsequently to the publication of the above article, the authors realized that Fig. 4 in their paper had been assembled containing two erroneously placed gel slices; essentially, the GAPDH bands featured in Fig. 4A had also been included in Fig. 5, and the data for the FKBP11 bands in Fig. 4A had also been included to show the GRP78 bands in Fig. 4. The authors were able to revisit their original
-
[Retracted] MicroRNA‑509 acts as a tumor suppressor in tongue squamous cell carcinoma by targeting epidermal growth factor receptor. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-02-01 Chao Hou, Yan Dong, Fenghe Zhang, Bo Du
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 2C on p. 7248 and Fig. 3G on p. 7249 were strikingly similar to data in different form in other articles written by different authors at different research institutes, which had either already been published (some of which have now
-
[Retracted] MicroRNA‑320 targets mitogen‑activated protein kinase 1 to inhibit cell proliferation and invasion in epithelial ovarian cancer. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Yongqian Xu, Jian Hu, Chunxia Zhang, Yuanyuan Liu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion assay data shown in Fig. 5C on p. 8534 were strikingly similar to data that had already been published in different form in different articles written by different authors at different research institutes, or were submitted for publication at around the same
-
Therapeutic strategies targeting the NLRP3‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Wan-Li Duan, Xue-Jie Wang, Ya-Ping Ma, Zhi-Mei Sheng, Hao Dong, Li-Ying Zhang, Bao-Gang Zhang, Mao-Tao He
Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need to be further clarified, and the associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome serves an important role in causing CIRI, and its activation exacerbates the underlying
-
CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Dahua Sun, Xiang Shi, Sanyan Li, Xiaohua Wang, Xiao Yang, Meiping Wan
Chimeric antigen receptor (CAR)‑T cell therapy is an innovative approach to immune cell therapy that works by modifying the T cells of a patient to express the CAR protein on their surface, and thus induce their recognition and destruction of cancer cells. CAR‑T cell therapy has shown some success in treating hematological tumors, but it still faces a number of challenges in the treatment of solid
-
Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Min Jia, Wenxue Liu, Keyin Zhang, Zhigang Wang, Ruisha Li, Jun Pan, Jianjun Yang, Dongjin Wang
Heart failure is a primary cause of global mortality. In the present study, whether larixyl acetate, an inhibitor of transient receptor potential cation channel subfamily C member 6, attenuates pressure overload‑induced heart failure in mice was investigated. To test this hypothesis, a transverse aortic constriction (TAC) animal model and an angiotensin II (Ang II)‑treated H9c2 cell model were used
-
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Mi-Hua Liu, Xiao-Long Lin, Le-Le Xiao
Hyperphosphatemia or severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can promote cardiovascular adverse events in patients with chronic kidney disease. Hyperphosphatemia is associated with elevated inflammation and sterol regulatory element binding protein 2 (SREBP2) activation, but the underlying mechanisms in SARS‑CoV‑2 that are related to cardiovascular disease remain unclear
-
Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long‑term follow‑up: A case report. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-26 Sachiko Yamasaki, Tomoaki Shintani, Toshinori Ando, Mutsumi Miyauchi, Souichi Yanamoto
Keratoameloblastoma (KA) and solid variant of odontogenic keratocyst (SOKC) are rare odontogenic lesions, and their relationship and differences are unclear. The present study described a case that started as an odontogenic keratocyst (OKC) and transformed to SOKC/KA upon recurrence. Briefly, a 26‑year‑old man presented with swelling in the right cheek and was referred to the Department of Oral and
-
Essential contribution of the JAK/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID‑19 (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Wenkai Li, Yunjing Zhuang, Song-Jun Shao, Pankaj Trivedi, Biying Zheng, Guo-Liang Huang, Zhiwei He, Xiangning Zhang
The intracellular pathway of Janus kinase/signal transducer and activator of transcription (JAK/STAT) and modification of nucleosome histone marks regulate the expression of proinflammatory mediators, playing an essential role in carcinogenesis, antiviral immunity and the interaction of host proteins with Herpesviral particles. The pathway has also been suggested to play a vital role in the clinical
-
Pharmacological activity of capsaicin: Mechanisms and controversies (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Wei Zhang, Yu Zhang, Jinke Fan, Zhiguo Feng, Xinqiang Song
Capsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then 'calms' them into long‑lasting non‑responsiveness. Capsaicin can also promote weight
-
Advances in the relationship between periodontopathogens and respiratory diseases (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Zhiyi Zhang, Siyi Wen, Jiaohong Liu, Yuanting Ouyang, Zhikang Su, Ding Chen, Zitian Liang, Yan Wang, Tao Luo, Qianzhou Jiang, Lvhua Guo
Periodontitis is a common chronic inflammatory and destructive disease in the mouth and is considered to be associated with systemic diseases. Accumulating evidence has suggested that periodontitis is a risk factor for pulmonary diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, coronavirus disease 2019 (COVID‑19) and lung cancer. The presence of common periodontal pathogens
-
Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Jiaqin Gao, Bin Zuo, Yang He
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive accumulation of extracellular matrix components and ongoing chronic inflammation. To date, early prevention of liver fibrosis remains challenging. As the most abundant non‑parenchymal hepatic cell population, liver
-
Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Caixia Bo, Yunfei Wang
Endometriosis (EM) is one of the most common diseases among women of reproductive age. The etiology and pathogenesis of EM remain unclear and therefore there is a lack of effective treatment measures, which affects physical and mental health, as well as the quality of life of patients with EM. Angiogenesis has become a hotspot for research on the pathogenesis of EM; the role of angiogenesis‑related
-
[Retracted] A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast‑like synoviocytes and inflammation in rheumatoid arthritis. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-19 Jinliang Gao, Wei Zheng, Liming Wang, Bailin Song
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blotting assay data shown in Figs. 1B and 5A and the histological data shown in Fig. 6C were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere
-
[Retracted] Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-12 Lei Yao, Mingtai Gui, Jianhua Li, Bo Lu, Jing Wang, Xunjie Zhou, Deyu Fu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the majority of the Histone H3 control western blotting data featured in Figs. 2D and 4C were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article
-
Mettl3‑mediated m6A RNA methylation regulates osteolysis induced by titanium particles. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-12 Xiaoxuan Lin, Yang Yang, Yaohong Huang, E Li, Xiumei Zhuang, Zhengchuan Zhang, Ruogu Xu, Xiaolin Yu, Feilong Deng
Peri‑prosthetic osteolysis (PPO) induced by wear particles is considered the primary cause of titanium prosthesis failure and revision surgery. The specific molecular mechanisms involve titanium particles inducing multiple intracellular pathways, which impact disease prevention and the targeted therapy of PPO. Notably, N6‑methyladenosine (m6A) serves critical roles in epigenetic regulation, particularly
-
[Corrigendum] Long non‑coding RNA HR1 participates in the expression of SREBP‑1c through phosphorylation of the PDK1/AKT/FoxO1 pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-12 Duan Li, Liwei Guo, Baoguo Deng, Min Li, Tingting Yang, Fan Yang, Zhijun Yang
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that the data panel for the "Huh7+BSA" experiment shown in Fig. 1D on p. 2852, showing the relative size of lipid droplets as determined in morphological studies using oil red O staining, had also appeared previously in the following article published by the same research group [Li D, Cheng M,
-
miR‑186‑5p regulates the inflammatory response of chronic obstructive pulmonary disorder by targeting HIF‑1α. Mol. Med. Rep. (IF 3.4) Pub Date : 2024-01-12 Yihui Fu, Jie Zhao, Jie Chen, Yamei Zheng, Rubing Mo, Lei Zhang, Bingli Zhang, Qi Lin, Chanyi He, Siguang Li, Lingsang Lin, Tian Xie, Yipeng Ding
Chronic obstructive pulmonary disorder (COPD) is a chronic respiratory disease that is a major cause of morbidity and mortality worldwide. Previous studies have shown that miR‑186‑5p expression is significantly increased in COPD and is involved in multiple physiological and pathological processes. However, the role of miRNA‑186‑5p in the inflammatory response of COPD remains unclear. In this study
-
Drynaria rhizome water extract alleviates high‑fat diet‑induced obesity in mice. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-22 Tae-Young Gil, Junkyu Park, Yea-Jin Park, Hyo-Jung Kim, Divina C Cominguez, Hyo-Jin An
Drynaria rhizome is a herbal medicine used for strengthening bones and treating bone diseases in East Asia. Although obesity is considered to benefit bone formation, it has been revealed that visceral fat accumulation can promote osteoporosis. Given the complex relationship between bone metabolism and obesity, bone‑strengthening medicines should be evaluated while considering the effects of obesity
-
Mitochondrial abnormality in ovarian granulosa cells of patients with polycystic ovary syndrome. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-22 Congcong Xie, Hui Lu, Xiujia Zhang, Zhuo An, Tong Chen, Wenbo Yu, Shusong Wang, Dandan Shang, Xueying Wang
The quality of oocytes in patients with polycystic ovary syndrome (PCOS) decreases, which is closely related to the function of oocytes' mitochondria. If mitochondrial dysfunction is involved in PCOS, it is likely to affect the function of cumulus cells. However, the mechanism of mitochondrial dysfunction remains unclear. In the present study, granulosa cells were collected from women attending the
-
[Retracted] MicroRNA‑29a inhibits cell migration and invasion by targeting Roundabout 1 in breast cancer cells. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-22 Hui Li, Jiashun Luo, Bin Xu, Kaijun Luo, Juan Hou
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the Transwell migration and invasion assay data shown in Fig. 3A and B were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper
-
Macrophages polarization in renal inflammation and fibrosis animal models (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-22 Ji Zeng, Yuan Zhang, Cheng Huang
Chronic kidney disease (CKD) is a significant public health concern. Renal fibrosis is the final common pathway in the progression of kidney diseases, irrespective of the initial injury. Substantial evidence underscores the pivotal role of renal inflammation in the genesis of renal fibrosis. The presence of macrophages within normal renal tissue is significantly increased within diseased renal tissue
-
Exploring the regulatory role of Linc00893 in asthenozoospermia: Insights into sperm motility and SSC viability. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Hui Lu, Dongchuan Xu, Liqiang Zhao, Hailing Ruan, Anguo Wang, Jiajia Hu, Meifang Xiao, Weiying Lu
The role of long intergenic noncoding RNA 00893 (Linc00893) in asthenozoospermia (AS) and its impact on sperm motility remains unclear The present study explored the effect of Linc00893 on AS, specifically its effect on sperm motility and its relationship with spermatogonial stem cell (SSC) vitality and myosin heavy chain 9 (MYH9) protein expression. Linc00893 expression was analyzed in semen samples
-
A frameshift mutation in the SCNN1B gene in a family with Liddle syndrome: A case report and systematic review. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Yiting Lu, Xinchang Liu, Lin Sun, Di Zhang, Peng Fan, Kunqi Yang, Lin Zhang, Yaxin Liu, Xianliang Zhou
Liddle syndrome is an autosomal dominant form of monogenic hypertension that is caused by mutations in SCNN1A, SCNN1B or SCNN1G, which respectively encode the α, β and γ subunits of the epithelial sodium channel. In the present study, DNA was extracted from leukocytes in peripheral blood obtained from all members of a family with Liddle syndrome. Whole‑exome sequencing and Sanger sequencing were performed
-
[Retracted] Downregulation of let‑7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Jinyan Liu, Chengqun Luo, Zhaoqi Yin, Ping Li, Shaohua Wang, Jia Chen, Quanyong He, Jianda Zhou
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the western blotting data shown in Figs. 4B and 5 and the H&E immunostaining data shown in Fig 1A were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published, or were submitted
-
Targeted reversal of multidrug resistance in ovarian cancer cells using exosome‑encapsulated tetramethylpyrazine. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Chenge Zhao, Lulu Qiu, Di Wu, Ming Zhang, Wanying Xia, Huiyi Lv, Lichun Cheng
The objective of the present study was to develop exosomes (EXOs) encapsulating tetramethylpyrazine (TMP) for the reversal of drug resistance in ovarian cancer therapy. Human A2780 cells were incubated with TMP for 48 h. Purified TMP‑primed EXOs (EXOs‑TMP) were isolated through ultracentrifugation. The developed EXOs‑TMP were characterized using techniques such as transmission electron microscopy,
-
Loss of keratin 23 enhances growth inhibitory effect of melatonin in gastric cancer. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Li Li, Meifang Lin, Jianhua Luo, Huaqin Sun, Zhiguang Zhang, Dacen Lin, Lushan Chen, Sisi Feng, Xiuping Lin, Ruixiang Zhou, Jun Song
To investigate the effect of keratin 23 (KRT23) on the anticancer activity of melatonin (MLT) against gastric cancer (GC) cells, microarray analysis was applied to screen differentially expressed genes in AGS GC cells following MLT treatment. Western blotting was used to detect the expression of KRT23 in GC cells and normal gastric epithelial cell line GES‑1. KRT23 knockout was achieved by CRISPR/Cas9
-
TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Xiaoqian Guo, Guangwei Qiao, Jingjiao Wang, Changyi Yang, Min Zhao, Qian Zhang, Yingbiao Wan
Diabetic periodontitis (DP) refers to destruction of periodontal tissue and absorption of bone tissue in diabetic patients. Tumor necrosis factor receptor‑associated factor (TRAF)‑interacting protein with forkhead‑associated domain (TIFA) as a crucial regulator of inflammation activates the NF‑κB signaling pathway to regulate cell biological behavior. However, the function and mechanism of TIFA on
-
Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Shu-Chi Cho, Shyh-Yu Shaw
Tea (Camellia sinensis) seed cake is a potential resource that contains a wealth of bioactive compounds. However, the high toxicity of tea saponins in tea seed cake restricts its applications. The present study aimed to i) develop a method of extracting bioactive compounds and reducing tea saponins during the process of tea seed cake extraction and ii) investigate the anti‑insulin resistance effect
-
Albumin, an interesting and functionally diverse protein, varies from 'native' to 'effective' (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-15 Nijin Wu, Tiantian Liu, Miaomiao Tian, Chenxi Liu, Shujun Ma, Huiling Cao, Hongjun Bian, Le Wang, Yuemin Feng, Jianni Qi
Human serum albumins (HSAs) are synthesized in the liver and are the most abundant proteins in plasma of healthy human. They play an important role in the pathophysiological processes of the liver and even the whole organism. Previous studies have mainly focused on the regulation of HSAs' expression. However, with the progress of research in recent years, it has been found that the content of circulating
-
Notoginsenoside R1 ameliorates the inflammation induced by amyloid‑β by suppressing SphK1‑mediated NF‑κB activation in PC12 cells. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-08 Xiaonan Wang, Bei Li, Xiaohong Yu, Ye Zhou, Kaile Wang, Yue Gao
Alzheimer's disease (AD) is the most common type of age‑related dementia, and causes progressive memory degradation, neuronal loss and brain atrophy. The pathological hallmarks of AD consist of amyloid‑β (Aβ) plaque accumulation and abnormal neurofibrillary tangles. Amyloid fibrils are constructed from Aβ peptides, which are recognized to assemble into toxic oligomers and exert cytotoxicity. The fibrillar
-
[Retracted] Tanshinone‑IIA attenuates the deleterious effects of oxidative stress in osteoporosis through the NF‑κB signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-08 Shaowen Zhu, Wanfu Wei, Zhiwei Liu, Yang Yang, Haobo Jia
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the images shown in Fig. 1E to represent the results from osteoclast differentation experiments were strikingly similar to data appearing in different form in another article written by different authors at different research institutes [Yang Y, Su Y, Wang D, Chen Y, Wu T, Li G, Sun X and Cui L:
-
Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-08 Aohong Xu, Lei Wang, Min Luo, Huan Zhang, Meiwei Ning, Jintong Pan, Xiuqun Duan, Yuxue Wang, Xiang Liu
Salusin‑β and adiponectin receptor 1 (adipoR1) serve important roles in the development of certain cardiovascular diseases and lipid metabolism. However, to the best of our knowledge, the relationship between salusin‑β and adipoR1, and their underlying mechanisms of action, currently remain unclear. In the present study, lentiviral vectors designed to overexpress salusin‑β or knock down salusin‑β expression
-
Transcriptomics reveal a molecular signature in the progression of nonalcoholic steatohepatitis and identifies PAI‑1 and MMP‑9 as biomarkers in in vivo and in vitro studies. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-01 Yao Zhao,Mirensha Yakufu,Chong Ma,Baicai Wang,Jianhua Yang,Junping Hu
Nonalcoholic steatohepatitis (NASH) is emerging as the primary driver of liver disease‑induced fibrosis. The imperative need for noninvasive biomarkers to ascertain disease progression stage is evident. The present study elucidated the biological roles of hub genes that could potentially serve as diagnostic markers for NASH. Using an in vivo approach, C57BL/6J mice were subjected to a high‑fat and
-
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-12-01 Ran Sun,Min Han,Yan Liu,Yong Su,Qifeng Shi,Lei Huang,Liangliang Kong,Weizu Li,Weiping Li
Diabetic kidney disease (DKD), one of the common complications of type‑2 diabetes mellitus (T2DM), has become the principal cause of end‑stage kidney disease. Transient receptor potential channel 6 (TRPC6), one of non‑selective cation channels with significant calcium‑permeability, is associated with renal fibrosis. However, the mechanism of TRPC6 in T2DM‑induced renal fibrosis is still not entirely
-
[Retracted] MACC‑1 antibody target therapy suppresses growth and migration of non‑small cell lung cancer. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Woda Shi, Jianxiang Song, Wencai Wang, Yajun Zhang, Shiying Zheng
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the control data in Fig. 2B and C on p. 7332, showing immunofluorescence and migration assay experiments respectively, were strikingly similar to data appearing in different form in another article which was written by different authors at different research institutes [Tian L, Shen D, Li X, Shan
-
Cord blood stem cell‑derived Angptl7 ameliorates the severity of bronchopulmonary dysplasia via anti‑inflammatory and proangiogenic effects. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Zhuxiao Ren, Liling Yang, Jianlan Wang, Jiangxue Han, Shouheng Lin, Yao Yao, Chen Du, Jie Yang
Perinatal exposure of the neonatal lung to inflammation leads to decreased lung angiogenesis and the development of bronchopulmonary dysplasia (BPD). Notably, autologous cord blood mononuclear cells (ACBMNCs) can substantially prevent severe BPD and decrease the inflammatory response in surviving very preterm neonates. Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in
-
Upregulated enhancer of rudimentary homolog promotes epithelial‑mesenchymal transition and cancer cell migration in lung adenocarcinoma. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Ying-Ming Tsai, Kuan-Li Wu, Yung-Chi Huang, Yu-Yuan Wu, Chao-Yuan Chang, Yung-Yun Chang, Hung-Hsing Chiang, Lian-Xiu Liu, Jen-Yu Hung
Lung adenocarcinoma (LUAD) is one of the deadliest cancers regarding both mortality rate and number of deaths and warrants greater effort in the development of potential therapeutic targets. The enhancer of rudimentary homolog (ERH) has been implicated in the promotion and progression of certain types of cancer. In the present study, ERH was assessed for its expression pattern and survival association
-
Aryl hydrocarbon receptor: An emerging player in breast cancer pathogenesis and its potential as a drug target (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Cong Chen, Zhiying Wang, Zhihong Liao, Yuanqi Zhang, Wei Lei, Xiaorong Shui
Breast cancer is the most common malignancy in women. Metastatic breast cancer is incurable and is a major cause of shortened patient survival. The different molecular types of breast cancer make targeted therapy difficult and a complex challenge. Aryl hydrocarbon receptor (AhR) is an evolutionarily conserved transcription factor that has been implicated in the metabolism of xenobiotic ligands. AhR
-
Insights into the relationship between serum uric acid and pulmonary hypertension (Review). Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Yu Zhou, Meihong Chen, Jing Zheng, Xiaorong Shui, Yuan He, Hui Luo, Wei Lei
Pulmonary hypertension (PH) is a progressive lethal disease, which is characterized by abnormal vascular remodeling and persistently elevated pulmonary artery pressure, eventually leading to right heart failure and even death. Although great progress has been made in treating PH, the mortality rate remains high. Metabolic disorders are one of the important hallmarks of PH. Obesity, lipids, glucose
-
The effect of lactate dehydrogenase inhibitors on proliferation, motility and invasion of breast cancer cells in vitro highlights a new role for lactate. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-24 Maitham A Khajah, Sarah Khushaish, Yunus A Luqmani
Lactate dehydrogenase (LDH) is being increasingly recognized as a major factor in the progression of breast cancer. It was previously shown that short interfering RNA‑mediated knockdown of either LDH‑A or ‑B isoform resulted in inhibition of cell motility due to reduced lactate levels in the extracellular environment. The aim of the present study was to determine the use of pharmacological LDH inhibitors
-
HSP90β regulates EAAT2 expression and participates in ischemia‑reperfusion injury in rats. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-17 Tao Liang, Xiaolin Hu, Ling Zeng, Zhiwei Zhou, Jun Zhang, Zucai Xu, Junwei Zeng, Ping Xu
Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury
-
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-17 Qi An, Jiejing Xia, Fanchun Pu, Shaobo Shi
Lipopolysaccharide‑induced (LPS) neuroinflammation serves an important role in the development of depression. Monocyte chemotactic protein‑1‑induced protein 1 (MCPIP1, also known as ZC3H12A and Regnase‑1) possesses endoribonuclease and deubiquitinase activities. In the present study, the effects of MCPIP1 on LPS‑induced depression were assessed. A mouse model of hippocampal neuroinflammation was established
-
[Retracted] The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway. Mol. Med. Rep. (IF 3.4) Pub Date : 2023-11-17 Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 4A were strikingly similar to data appearing in different form in another article written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published prior