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Preoperative prediction for early recurrence of hepatocellular carcinoma using machine learning-based radiomics Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Bing Mao, Yajun Ren, Xuan Yu, Xinliang Liang, Xiangming Ding
ObjectiveTo develop a contrast-enhanced computed tomography (CECT) based radiomics model using machine learning method and assess its ability of preoperative prediction for the early recurrence of hepatocellular carcinoma (HCC).MethodsA total of 297 patients confirmed with HCC were assigned to the training dataset and test dataset based on the 8:2 ratio, and the follow-up period of the patients was
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Single brain metastases – prognostic factors and impact of residual tumor burden on overall survival Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Lea Baumgart, Aida Anetsberger, Amir Kaywan Aftahy, Benedikt Wiestler, Denise Bernhardt, Stephanie E. Combs, Hanno S. Meyer, Gerhard Schneider, Bernhard Meyer, Jens Gempt
BackgroundBrain metastases (BM) are a common and challenging issue, with their incidence on the rise due to advancements in systemic therapies and increased patient survival. Most patients present with single BM, some of them without any further extracranial metastasis (i.e., solitary BM). The significance of postoperative intracranial tumor volume in the treatment of singular and solitary BM is still
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Case report: Isolated eyelid metastasis of ccRCC 5 years after receiving radical nephrectomy Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Huaqi Yin, Zheng Du, Jiuwen Zhang, Yongkang Ma, Shiming Zhao, Tiejun Yang
IntroductionThe most common sites of clear cell renal cell carcinoma(ccRCC) metastasis are the lung, bones, liver and brain; eyelid metastasis is a rare occurrence.Case presentationWe report a case of ccRCC metastasis to the left eyelid after radical nephrectomy, and remission after sunitinib treatment.ConclusionsAlthough the probability of eyelid metastasis rate is very low, tumor metastasis to the
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Risk factors analysis and the establishment of nomogram prediction model for PICC-related venous thrombosis in patients with lymphoma: a double-center cohort-based case-control study Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Xue-xing Wang, Yuan He, Jie Chu, Jin-song Xu
ObjectiveThe objective of this study is to examine the risk factors associated with the occurrence of PICC-Related Venous Thrombosis (PICC-RVTE) in individuals diagnosed with lymphoma, as well as to develop a predictive risk nomogram model.MethodsA total of 215 patients with lymphoma treated at Yunnan Provincial Tumor Hospital from January 2017 to December 2020 were retrospectively evaluated as the
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The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Somayeh Jafari, Hossein Motedayyen, Parisa Javadi, Kazem Jamali, Amin Moradi Hasan-Abad, Amir Atapour, Gholamreza Anani Sarab
Pancreatic ductal adenocarcinoma (PDAC) is among the most penetrative malignancies affecting humans, with mounting incidence prevalence worldwide. This cancer is usually not diagnosed in the early stages. There is also no effective therapy against PDAC, and most patients have chemo-resistance. The combination of these factors causes PDAC to have a poor prognosis, and often patients do not live longer
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SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignancies Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Jonahunnatha Nesson George William, Ruby Dhar, Rohit Gundamaraju, Om Saswat Sahoo, Karthikeyan Pethusamy, A. F. P. Allwin Mabes Raj, Subbiah Ramasamy, Mohammed S. Alqahtani, Mohamed Abbas, Subhradip Karmakar
SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family of substrate-recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with ubiquitin-mediated degradation in the mammalian cell cycle components and other target proteins involved in cell cycle progression, signal transduction, and transcription. Being an oncogene in solid tumors and hematological
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Mechanism of action of nadofaragene firadenovec-vncg Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Vikram M. Narayan, Joshua J. Meeks, Jørn S. Jakobsen, Neal D. Shore, Grannum R. Sant, Badrinath R. Konety
Effective bladder-preserving therapeutic options are needed for patients with bacillus Calmette-Guérin unresponsive non–muscle-invasive bladder cancer. Nadofaragene firadenovec-vncg (Adstiladrin®) was approved by the US Food and Drug Administration as the first gene therapy in urology and the first intravesical gene therapy indicated for the treatment of adult patients with high-risk bacillus Calm
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Association of cancer diagnosis with disability status among older survivors of colorectal cancer: a population-based retrospective cohort study Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Shiming Zhang, Lin-Na Chou, Michael D. Swartz, Hemalkumar B. Mehta, James S. Goodwin, Yong-Fang Kuo, Sharon Hermes Giordano, Carole A. Tucker, Karen M. Basen-Engquist, Elizabeth J. Lyons, Brian Downer, Susan K. Peterson, Tru Cao, Maria C. Swartz
BackgroundOlder cancer survivors likely experience physical function limitations due to cancer and its treatments, leading to disability and early mortality. Existing studies have focused on factors associated with surgical complications and mortality risk rather than factors associated with the development of poor disability status (DS), a proxy measure of poor performance status, in cancer survivors
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Development of a nomogram for predicting the high-risk groups of solid-pseudopapillary neoplasms of the pancreas Front. Oncol. (IF 4.7) Pub Date : 2024-03-15 Xiaocheng Li, Jianji Ke, Xinlun Dai, Liang Guo, Li Zhang, Yahui Liu, Bai Ji
BackgroundSolid pseudopapillary neoplasms (SPNs) of the pancreas are indolent rare tumors with malignant potential. The risk factors associated with the malignant behavior of SPNs are still unclear.MethodsA retrospective analysis of patients with SPNs who underwent surgical treatment in the First Hospital of Jilin University from January 2010 to January 2022 was conducted. The clinical baseline data
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Tislelizumab induced dual organs dysfunction in a patient with advanced esophageal squamous cell carcinoma: a case report Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Bo Yang, Wei Gou, Naiying Lan, Qing Shao, Weifeng Hu, Cheng Xue, Nanmei Liu
BackgroundTislelizumab, a humanized IgG4 anti-PD-1 monoclonal antibody has been approved in China and Europe. According to the published clinical research, tislelizumab shows satisfactory safety profile. No severe hepatotoxicity or acute kidney injury were reported.Case presentationWe presented a case study of a 74-year-old man who developed acute kidney injury (grade 3) and acute liver injury (grade
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Effectiveness of sigmoidoscopy or colonoscopy screening on colorectal cancer incidence and mortality: a systematic review and meta-analysis of randomized controlled trial Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Chunyang Han, Fan Wu, Jian Xu
ObjectivesWe conducted a comprehensive analysis to compare colonoscopy and sigmoidoscopy with standard care or fecal immunochemistry regarding colorectal cancer incidence and mortality risk.MethodsUntil August 2023, literature from PubMed, Embase, Web of Science, and Cochrane was systematically reviewed. We examined the impact of colonoscopy or sigmoidoscopy versus standard care on colorectal cancer
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Machine learning models based on quantitative dynamic contrast-enhanced MRI parameters assess the expression levels of CD3+, CD4+, and CD8+ tumor-infiltrating lymphocytes in advanced gastric carcinoma Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Huizhen Huang, Zhiheng Li, Dandan Wang, Ye Yang, Hongyan Jin, Zengxin Lu
ObjectiveTo explore the effectiveness of machine learning classifiers based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the expression levels of CD3+, CD4+, and CD8+ tumor-infiltrating lymphocytes (TILs) in patients with advanced gastric cancer (AGC).MethodsThis study investigated 103 patients with confirmed AGC through DCE-MRI and immunohistochemical staining. Immunohistochemical
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Prognostic nomogram in patients with right-sided colon cancer after colectomy: a surveillance, epidemiology, and end results–based study Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Tiantian Qin, Chenyue Yu, Yuying Dong, Mingming Zheng, Xiaoxuan Wang, Xuning Shen
ObjectiveThis study aimed to develop and validate a nomogram for predicting overall survival (OS) in patients undergoing surgery for right-sided colon cancer (RCC).MethodsWe collected 25,203 patients with RCC from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided them into 7:3 training and internal validation set. Utilizing the Cox proportional hazards regression
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The global landscape and research trend of lymphangiogenesis in breast cancer: a bibliometric analysis and visualization Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Liuyan Xu, Xuan Wang, Beibei Wang, Bingxin Meng, Xiaohua Pei
BackgroundBreast cancer persists as a major public health issue on a global scale. Lymphangiogenesis is an indispensable element in the promotion of breast cancer metastasis. Inhibiting the metastasis of breast cancer can be accomplished through targeting lymphangiogenesis. The purpose of this study was to examine research trends, major topics, and development directions of lymphangiogenesis in breast
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Case report: An atypical case of uterine adenosarcoma with extensive bizarre stromal cells and amplification of MDM2 Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Xiaoling Xiao, Ying He
Polypoid lesions in the uterus are very common. There are a lot of benign lesions and malignant tumor should be considered. Adenosarcoma, one of the differential diagnoses, is a rare mixed epithelial and mesenchymal tumor consisting of benign epithelial components and sarcoma stroma. Here, we present a case of atypical adenosarcoma that has never been reported. This tumor was composed of benign endometrial
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Sarcopenia accompanied by systemic inflammation can predict clinical outcomes in patients with head and neck cancer undergoing curative therapy Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Ken Kasahara, Takeyuki Kono, Yoichiro Sato, Masafumi Ueno, Hirotaka So, Yoshimitsu Fuse, Seiichi Shinden, Hiroyuki Ozawa
ObjectivesEvaluation of sarcopenia accompanied by systemic inflammation status is a more beneficial prognostic marker than sarcopenia alone in various cancers. However, few studies have focused on this combination in patients with head and neck squamous cell cancer (HNSCC). In this study, we investigated how the combination of sarcopenia and systemic inflammation could affect survival in patients with
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Evaluation of hepatic functional reserve of hepatocellular carcinoma (≤ 5 cm) by liver shear wave velocity combined with multiple parameters Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Long Yang, Haohui Zhu, Xijun Zhang, Xiaobing Fu, Xiaojuan Zhao, Xiaojing Wang, Xiaozhuan Ren, Haibo Yu, Jianjun Yuan
BackgroundNormal hepatic functional reserve is the key to avoiding liver failure after liver surgery. This study investigated the assessment of hepatic functional reserve using liver shear wave velocity (LSWV) combined with biochemical indicators, tumor volume, and portal vein diameter.MethodsIn this single-center prospective study, a total of 123 patients with hepatocellular carcinoma (HCC) were divided
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DDX58 deficiency leads to triple negative breast cancer chemotherapy resistance by inhibiting Type I IFN-mediated signalling apoptosis Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Shiyu Cao, Xinyi Long, Lin Xiao, Peichuan Zhang, Mengjia Shen, Fei Chen, Chunjuan Bao, Xiaorong Zhong, Ting Luo, Feng Ye
IntroductionTriple-negative breast cancer (TNBC) is characterized by its aggressive nature and absence of specific therapeutic targets, necessitating the reliance on chemotherapy as the primary treatment modality. However, the drug resistance poses a significant challenge in the management of TNBC. In this study, we investigated the role of DDX58 (DExD/H-box helicase 58), also known as RIG-I, in TNBC
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Case report: Targeted treatment strategies for Erdheim-Chester disease Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Anita Gulyás, László Imre Pinczés, János Mátyus, Edit Végh, Judit Bedekovics, Judit Tóth, Sándor Barna, Zsolt Hunya, Imre Lőrinc Szabó, Annamária Gazdag, Árpád Illés, Ferenc Magyari
IntroductionErdheim-Chester disease (ECD) is a rare disease that belongs to the group of Dendritic and histiocytic neoplasms. Only 2000 cases have been reported worldwide. It can present with a wide range of symptoms, making a differential diagnosis especially difficult. The primary and most important diagnostic tool is a biopsy of the affected organ/tissue. Nowadays the analysis of different mutations
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Testicular metastasis from urothelial carcinoma: case report and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Changxue Liu, Jing Liu, Qingbo Yang, Leilei Song, Xiaocheng Ma, Yonghua Wang
Urothelial carcinoma (UC) with testicular metastasis is extremely rare, and its modes of metastasis, prognosis, and treatment are unclear. In this report, we present an extraordinarily rare case of testicular metastasis arising from UC 8 years after surgery. The patient underwent left orchiepididymectomy and received immunotherapy postoperatively. After a 6-month follow-up, there were no signs of recurrence
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Case report: Turcot syndrome type 2 in a developing country within the Caribbean Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Melissa Daniel-Abdool, Brandon Griffith, Ute Bartels, Curt Bodkyn, Kevon Dindial
Medulloblastoma is the most common malignant pediatric brain tumor and has been linked to known cancer predisposition syndromes. We report a case of medulloblastoma of a 12-year-old Indo-Trinidadian female with a strong family history of colorectal carcinoma. In collaboration with the SickKids-Caribbean Initiative (SCI), her tumor was confirmed to be a WHO grade 4 medulloblastoma – Wnt subtype. Genetic
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Moving from conventional to adaptive risk stratification for oropharyngeal cancer Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Vlad C. Sandulache, R. Parker Kirby, Stephen Y. Lai
Oropharyngeal cancer (OPC) poses a complex therapeutic dilemma for patients and oncologists alike, made worse by the epidemic increase in new cases associated with the oncogenic human papillomavirus (HPV). In a counterintuitive manner, the very thing which gives patients hope, the high response rate of HPV-associated OPC to conventional chemo-radiation strategies, has become one of the biggest challenges
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Neoadjuvant ipilimumab plus nivolumab therapy as a potential organ preservation strategy in mucosal melanoma: case report Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Claire V. Ong, Wolfram Samlowski
Mucosal melanoma represents an uncommon melanoma subtype. Wide excision has long represented the standard therapeutic approach. Unfortunately, there is a high relapse rate and mortality. Neoadjuvant therapy with ipilimumab plus nivolumab has shown significant activity in cutaneous melanoma. We present two cases of mucosal melanoma, each with potential regional dissemination, who were treated with neoadjuvant
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The fertility-sparing treatment and outcome of epithelioid trophoblastic tumor isolated to lung: a case report and review literature Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Zengshu Huang, Yingjuan Yu, Darong Wen, Nan Wang, Liping Zeng
BackgroundEpithelioid trophoblastic tumor (ETT) is the rarest gestational trophoblastic tumor, with poor response to chemotherapy. Hysterectomy, as the cornerstone therapy for early ETT, is particularly challenging in reproductive-age women who often have a strong desire for fertility preservation. The management of extra-uterine ETT could be even more complicated and inconsistent. Here we reported
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Clinical acceptance and dosimetric impact of automatically delineated elective target and organs at risk for head and neck MR-Linac patients Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Vesela Koteva, Björn Eiben, Alex Dunlop, Amit Gupta, Tarun Gangil, Kee Howe Wong, Sebastiaan Breedveld, Simeon Nill, Kevin Harrington, Uwe Oelfke
BackgroundMR-Linac allows for daily online treatment adaptation to the observed geometry of tumor targets and organs at risk (OARs). Manual delineation for head and neck cancer (HNC) patients takes 45-75 minutes, making it unsuitable for online adaptive radiotherapy. This study aims to clinically and dosimetrically validate an in-house developed algorithm which automatically delineates the elective
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Multimodal data integration for predicting progression risk in castration-resistant prostate cancer using deep learning: a multicenter retrospective study Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Chuan Zhou, Yun-Feng Zhang, Sheng Guo, Yu-Qian Huang, Xiao-Ni Qiao, Rong Wang, Lian-Ping Zhao, De-Hui Chang, Li-Ming Zhao, Ming-Xu Da, Feng-Hai Zhou
PurposePatients with advanced prostate cancer (PCa) often develop castration-resistant PCa (CRPC) with poor prognosis. Prognostic information obtained from multiparametric magnetic resonance imaging (mpMRI) and histopathology specimens can be effectively utilized through artificial intelligence (AI) techniques. The objective of this study is to construct an AI-based CRPC progress prediction model by
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Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors Front. Oncol. (IF 4.7) Pub Date : 2024-03-14 Tianwei Zhang, Bin Zeng, Ke Liu, Qin Zeng, Na Wang, Ling Peng, Hongbo Qiu, Xiaomei Chen, Lin Wang
Tendon Sheath Giant Cell Tumor (TGCT) is a benign tumor that primarily grows within joints and bursae. However, it has a high postoperative recurrence rate, ranging from 15% to 45%. Although radiotherapy may reduce this recurrence rate, its applicability as a standard treatment is still controversial. Furthermore, the pathogenic mechanisms of TGCT are not clear, which limits the development of effective
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Unraveling trajectories from aplastic anemia to hematologic malignancies: genetic and molecular insights Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Namsoo Kim, Yu Jeong Choi, Seung-Tae Lee, Jong Rak Choi, Chuhl Joo Lyu, Saeam Shin, June-Won Cheong
BackgroundAplastic anemia (AA), characterized by hematopoietic stem cell deficiency, can evolve into different hematologic malignancies. Our understanding of the genetic basis and mechanisms of this progression remains limited.MethodsWe retrospectively studied 9 acquired AA patients who later developed hematologic malignancies. Data encompassed clinical, laboratory, karyotype, and next-generation sequencing
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Military environmental exposures and risk of breast cancer in active-duty personnel and veterans: a scoping review Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Dylan J. Jester, Mehret T. Assefa, Daya K. Grewal, Abou M. Ibrahim-Biangoro, Jennifer S. Jennings, Maheen M. Adamson
BackgroundThe effects of military environmental exposures (MEE) such as volatile organic compounds (VOCs), endocrine-disrupting chemicals (EDCs), tactile herbicides, airborne hazards and open burn pits (AHOBP), and depleted uranium on health are salient concerns for service members and Veterans. However, little work has been done to investigate the relationship between MEE and risk of breast cancer
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Mapping breast and prostate cancer in the Brazilian public health system: study protocol of the Onco-Genomas Brasil Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Jaqueline Bohrer Schuch, Cláudia Bordignon, Mahira Lopes Rosa, Angélica Cerveira de Baumont, Marina Bessel, Gabriel S. Macedo, Daniela Dornelles Rosa
BackgroundBreast and prostate cancers are the most common malignancies diagnosed in women and men respectively, and present with great clinical heterogeneity, even in tumors with the same histology and same site of origin. Somatic and germline molecular alterations in DNA may have prognostic and predictive impact, influencing response to therapies and overall survival. Our aim is to characterize the
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Patient-reported outcomes in Hodgkin lymphoma trials: a systematic review Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Esther Natalie Oliva, Tatyana Ionova, Edward Laane, Mario Csenar, Julia Schroer, Karolin Behringer, Ina Monsef, Annika Oeser, Nicole Skoetz, Sam Salek
BackgroundLymphoma treatment can lead to long-term consequences such as fatigue, infertility and organ damage. In clinical trials, survival outcomes, clinical response and toxicity are extensively reported while the assessment of treatment on quality of life (QoL) and symptoms is often lacking.ObjectiveWe evaluated the use and frequency of patient-reported outcome (PRO) instruments used in randomized
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Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Matías J. Dahl, Kristopher A. Lofgren, Cleo Haugen, Gil E. Harmon, Sarah P. Hughes, Karen D. Cowden Dahl
Uterine carcinosarcoma (UCS) is a rare but aggressive endometrial cancer. Survival outcomes for women diagnosed with UCS remain poor with lower survival than those of endometrioid or high-grade serous uterine cancers. The histopathological hallmark of carcinosarcoma is the presence of both sarcomatous and carcinomatous elements. The survival rates for UCS have not improved for over 40 years; therefore
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Unusual presentation of glioblastoma in the brainstem: a case report of a diffuse pontine glioblastoma multiforme and surgical management Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Brandon Edelbach, Vadim Gospodarev, Miguel Lopez-Gonzalez, Jeremy Deisch, Maninder Kaur
Diffuse pontine glioblastoma multiforme is a rare subtype of glioblastoma associated with a poor prognosis. In this case report, we present a unique case of diffuse primary pontine glioblastoma multiforme in a patient without any supratentorial lesions. We review the symptoms, treatment options, and case management of patients with infratentorial glioblastoma multiforme and compare these with our patient
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Radical prostatectomy versus radiotherapy as local therapy for primary tumors in patients with oligometastatic prostate cancer Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Won Sik Ham, Jee Soo Park, Won Sik Jang, Jongchan Kim
IntroductionWe compared radical prostatectomy (RP) and radiotherapy (RT) as local therapies for primary tumors and examined their associations with survival outcomes and urinary tract complications in patients with oligometastatic prostate cancer (omPC).MethodsWe evaluated the data of 85 patients diagnosed with omPC who underwent local therapy for primary tumors between January 2008 and December 2018
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Animal model considerations for chordoma research: reproducing the tumor microenvironment in vivo with humanized mice Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Beatrice Campilan, Christian Schroeder, Emilija Sagaityte, Jonathan Arditi, Owen P. Leary, Ziya L. Gokaslan, Patricia L. Zadnik Sullivan, Margot Martinez-Moreno
Animal models have been commonly used in immunotherapy research to study the cell response to external agents and to assess the effectiveness and safety of new therapies. Over the past few decades, immunocompromised (also called immunodeficient) mice allowed researchers to grow human tumor cells without the impact of the host’s immune system. However, while this model is very valuable to understand
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Emerging role of m6A modification in ovarian cancer: progression, drug resistance, and therapeutic prospects Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Shahil Alam, Pankaj Kumar Giri
Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial Ovarian Cancer (EOC). Despite advancements in treatment modalities, the prognosis for OC patients remains grim due to limitation of current therapeutic methodology such as high cytotoxicity of chemotherapeutic agents and tumor relapse making
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BRCA1/2 alterations and reversion mutations in the area of PARP inhibitors in high grade ovarian cancer: state of the art and forthcoming challenges Front. Oncol. (IF 4.7) Pub Date : 2024-03-13 Laetitia Collet, Brunhilde Hanvic, Margherita Turinetto, Isabelle Treilleux, Nicolas Chopin, Olivia Le Saux, Isabelle Ray-Coquard
BRCA1/2 genes are part of homologous recombination (HR) DNA repair pathways in charge of error-free double-strand break (DSB) repair. Loss-of-function mutations of BRCA1/2 genes have been associated for a long time with breast and ovarian cancer hereditary syndrome. Recently, polyadenosine diphosphate–ribose polymerase inhibitors (PARPi) have revolutionized the therapeutic landscape of BRCA1/2-mutated
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Targeting of lysosomal-bound protein mEAK-7 for cancer therapy Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Insoon Chang, Yi-Ling Loo, Jay Patel, Joe Truong Nguyen, Jin Koo Kim, Paul H. Krebsbach
mEAK-7 (mammalian EAK-7 or MTOR-associated protein, eak-7 homolog), is an evolutionarily conserved lysosomal membrane protein that is highly expressed in several cancer cells. Multiple recent studies have identified mEAK-7 as a positive activator of mTOR (mammalian/mechanistic target of rapamycin) signaling via an alternative mTOR complex, implying that mEAK-7 plays an important role in the promotion
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Case report: Bronchoscopic intervention for rare benign airway tumors: a report of 4 cases and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Zhifang Cui, Jinhong Wang, Hongwu Wang, Lei Li, Xiaohui Si, Yanbin Zhang, Heng Zou
Due to their unique location, airway tumors have a significant impact on patient quality of life and survival. Current research has focused extensively on malignant airway tumors; however, benign airway tumors, especially rare ones, are less understood due to their low incidence. These tumors are often misdiagnosed and mistreated due to diagnostic challenges. Therefore, there is still a lack of consensus
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Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Longhao Chen, Liuji He, Baijie Liu, Yinghua Zhou, Lijiang Lv, Zhiguang Wang
BackgroundOsteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent
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Meta-analysis of dynamic contrast enhancement and diffusion-weighted MRI for differentiation of benign from malignant non-mass enhancement breast lesions Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Jing Zhang, Longchao Li, Li Zhang, Xia Zhe, Min Tang, Xiaoyan Lei, Xiaoling Zhang
PurposeThe objective of this study was to conduct a meta-analysis comparing the diagnostic efficacy of models based on diffusion-weighted imaging (DWI)-MRI, dynamic contrast enhancement (DCE)-MRI, and combination models (DCE and DWI) in distinguishing benign from malignant non-mass enhancement (NME) breast lesions.Materials and methodsPubMed, Embase, and Cochrane Library were searched, from inception
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Hemophagocytic lymphohistiocytosis during treatment of intracranial multifocal germinoma: a case report and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Ting Guo, Zichun Liu, Yixin Chen, Yangyang Cheng, Kaitong He, Xin Lin, Mingzhu Wang, Yihua Sun
Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome (HPS), is a benign histiocytosis with hyperreactive proliferation of the mononuclear phagocyte system caused by immune function abnormalities, which often occurs under the background of genetic mutations, inflammation, infection or tumors. Because the research on malignancy-associated HLH (M-HLH) is focused on hematological
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“There is nothing that can prevent me from supporting her:” men’s perspectives on their involvement and support of women’s use of topical therapy for cervical precancer treatment in Kenya Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Chemtai Mungo, Konyin Adewumi, Everlyn Adoyo, Graham Zulu, Supreet Kaur Goraya, Cirillus Ogollah, Jackton Omoto, Renée M. Ferrari, Lisa Rahangdale
PurposeCervical cancer disproportionately impacts women in low- and middle-income countries (LMICs). The World Health Organization’s (WHO) 90/70/90 strategy aims to eliminate cervical cancer by 2030 by increasing HPV vaccination coverage to 90%, screening 70% of eligible women, and effectively treating 90% of those with abnormal results by 2030, potentially preventing 62 million deaths in LMICs. LMICs
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Novel biomarkers of inflammation-associated immunity in cervical cancer Front. Oncol. (IF 4.7) Pub Date : 2024-03-12 Weihong Zhao, Qi Li, Songquan Wen, Yaqin Li, Ying Bai, Zhiyu Tian
BackgroundCervical cancer (CC) is a highly malignant gynecological cancer with a direct causal link to inflammation, primarily resulting from persistent high-risk human papillomavirus (HPV) infection. Given the challenges in early detection and mid to late-stage treatment, our research aims to identify inflammation-associated immune biomarkers in CC.MethodsUsing a bioinformatics approach combined with
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Case report: A case of metastatic BRAFV600-mutated melanoma with heart failure treated with immune checkpoint inhibitors and BRAF/MEK inhibitors Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BackgroundNovel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction.Case reportA 42-year-old male patient with no significant medical history noticed
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A rare huge bladder inflammatory myofibroblastic tumor treated by en bloc resection with diode laser: a case report and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Huisheng Yuan, Zilong Wang, Jiaxing Sun, Junhao Chu, Shishuai Duan, Muwen Wang
BackgroundInflammatory myofibroblastic tumor (IMT) is a rare neoplasm with malignant potential. Bladder IMT is even rarer and mainly treated by surgical resection However, partial or radical cystectomy would affect the quality of life of patients due to major surgical trauma, and classical TURBT is hard to avoid intraoperative complications including obturator nerve reflex and bleeding etc. Therefore
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Composite diffuse large B-cell lymphoma and peripheral T-cell lymphoma: a case report with two-year follow-up and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Jiwei Gu, Juan Qian, Xin Cao
Composite lymphoma is an uncommon type of lymphoid malignancy, and those consisting of concurrent diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in the same organ are rare. Here, we report a case of a 75-year-old male patient admitted to our emergency department with intestinal obstruction presenting with abdominal pain and vomiting. He underwent
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Diagnosis of benign and malignant peripheral lung lesions based on a feature model constructed by the random forest algorithm for grayscale and contrast-enhanced ultrasound Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Hong Wei, Yichun Wang, Jinyao Li, Yanyan Wang, Longdi Lu, Jiawei Sun, Xiaolei Wang
Rationale and objectivesTo construct a predictive model for benign and malignant peripheral pulmonary lesions (PPLs) using a random forest algorithm based on grayscale ultrasound and ultrasound contrast, and to evaluate its diagnostic value.Materials and methodsWe selected 254 patients with PPLs detected using chest lung computed tomography between October 2021 and July 2023, including 161 malignant
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Beneficial implications of adjuvant chemotherapy for stage IB lung adenocarcinoma exhibiting elevated SUVmax in FDG-PET/CT: a retrospective study from a single center Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Miao Huang, Bing Liu, Xiang Li, Nan Li, Xin Yang, Yaqi Wang, Shanyuan Zhang, Fangliang Lu, Shaolei Li, Shi Yan, Nan Wu
BackgroundControversy surrounds the efficacy of adjuvant chemotherapy (ACT) in the treatment of stage I lung adenocarcinoma (LUAD). The objective of this study was to examine the impact of the maximum standardized uptake value (SUVmax) as measured by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on the efficacy of ACT in patients diagnosed with stage I LUAD.MethodsWe
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The learning curve and experience of a novel multi-modal image fusion targeted transperineal prostate biopsy technique using electromagnetic needle tracking under local anesthesia Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Yongjun Yang, Xianya He, Yiming Zeng, Qiang Lu, Yuanwei Li
BackgroundProstate cancer is the most common malignant tumor of male genitourinary system, and the gold standard for its diagnosis is prostate biopsy. Focusing on the methods and skills of prostate biopsy, we explored the learning curve and experience of a novel magnetic resonance imaging and transrectal ultrasound (mpMRI-TRUS) image fusion transperineal biopsy (TPB) technique using electromagnetic
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EVA1A, a novel and promising prognostic biomarker in colorectal cancer Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Hai-hua Fan, Hai-jun Zhang
PurposeThe purpose of this study was to investigate the potential of EVA1A as a prognostic biomarker for Colorectal cancer (CRC).MethodsThe study utilized public databases to analyze the difference in Evala mRNA expression between CRC tumor tissues and adjacent normal tissues. Additionallymunohistochemical staining was performed on 90 paired tissue samples to detect EVA1A expression. The relationship
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Management of Trastuzumab Deruxtecan-related nausea and vomiting in real-world practice Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Giulia Notini, Matteo Maria Naldini, Lorenzo Sica, Giulia Viale, Alessia Rognone, Stefania Zambelli, Patrizia Zucchinelli, Marta Piras, Carlo Bosi, Marco Mariani, Daniela Aldrighetti, Giampaolo Bianchini, Luca Licata
BackgroundNausea and vomiting are common side effects of Trastuzumab Deruxtecan (T-DXd), but guidelines for optimal management were not initially available. This retrospective single-center study aimed at evaluating the efficacy of two antiemetic regimens in patients receiving T-DXd.MethodsData from metastatic breast cancer patients receiving T-DXd were collected. Two groups were defined: patients
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The application of artificial intelligence for Rapid On-Site Evaluation during flexible bronchoscopy Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Shuang Yan, Yongfei Li, Lei Pan, Hua Jiang, Li Gong, Faguang Jin
BackgroundRapid On-Site Evaluation (ROSE) during flexible bronchoscopy (FB) can improve the adequacy of biopsy specimens and diagnostic yield of lung cancer. However, the lack of cytopathologists has restricted the wide use of ROSE.ObjectiveTo develop a ROSE artificial intelligence (AI) system using deep learning techniques to differentiate malignant from benign lesions based on ROSE cytological images
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The imaging features of ectopic spleen: which modality is more consistent? A cases series report and literature reviews Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Mingyue Xiao, Jiayi Liang, Jie Ren, Rongqin Zheng, Lili Wu
Ectopic spleen (ES) is a rare condition. It is difficult to diagnose with conventional imaging modalities. In this case series, we presented the imaging features of three misdiagnosed ES cases in our hospital and previously reported cases to compare the consistency of enhancement patterns among different imaging modalities with varied phases. Finally, 22 cases were reviewed. We determined that variable
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Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Xiaoling Zhong, Guohua Zeng, Lixiang Zhang, Shuyuan You, Yuxiang Fu, Wan He, Guixiang Liao
PurposeTo investigate the predictive factors of pathologic complete response (pCR) in locally advanced rectal cancer (LARC) patients who had been treated with neoadjuvant chemoradiation (nCRT).Methods and materialsFor this retrospective study, 53 LARC patients (37 males and 16 females; age range 25 to 79 years) were selected. Clinical characteristics, baseline mrTNM staging, MR gross tumor volumes
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Primary pure large cell neuroendocrine carcinoma of the urinary bladder: a case report and literature review Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Zhenpeng Sun, Xin Liang, Changcun Zhang, Shizhang Song, Jiangang Gao
BackgroundThe large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is a rare malignancy. With its high aggressiveness and poor prognosis, the disease is often accompanied by metastasis or recurrence. The lack of specific clinical manifestations and imaging features causes considerable challenges for clinical diagnosis and treatment.Case presentationWe report a case of LCNEC of the urinary
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Numb cheek syndrome in breast cancer: a case report Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Zhibin Tan, Si Ying Tan
BackgroundNumb cheek syndrome, a rare corollary of numb chin syndrome, is due to infra-orbital neuropathy. It can occur in association with an underlying malignancy, which can cause neuropathy by direct malignant nerve infiltration or via a paraneoplastic mechanism. Although numb cheek syndrome has been reported in association with a variety of cancers, it has previously not been reported in association
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Case report: Immunotherapy in rare high TMB pancreatic acinar carcinoma Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Guifu Wu, Yuting Fang, Deying Bi, Wenwei Yang, Yongkun Sun
This case report details a patient with Pancreatic Acinar Cell Carcinoma (PACC), a rare malignancy with distinctive biological and imaging features. In the absence of standardized treatment protocols for PACC, we embarked on a diagnostic journey that led to the adoption of an innovative therapeutic regimen in our institution. A 45-year-old female patient presented with a pancreatic mass, which was
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Efficacy of osimertinib and the role of sequential liquid biopsy in patients diagnosed with NSCLC harboring EGFR and BRAF mutations at baseline: insights from two case reports Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Loc Carlo Bao, Alessia Padovan, Andrea Boscolo Bragadin, Lorenzo Calvetti, Valentina Guarneri, Laura Bonanno, Stefano Indraccolo
Epidermal Growth Factor Receptor (EGFR) and B-Raf (BRAF) mutations are two of the most important drivers identified in non-small-cell lung cancer (NSCLC). This report highlights two cases of patients diagnosed with metastatic NSCLC bearing concurrent EGFR and BRAF mutations at baseline and treated with osimertinib as first-line treatment. Molecular profiling was conducted in the tissue and plasma at
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A dynamic study of VEGF-A siDOX-EVs trafficking through the in-vitro insert co-culture blood-brain barrier model by digital holographic microscopy Front. Oncol. (IF 4.7) Pub Date : 2024-03-11 Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Fahimeh Hajiahmadi, Ali-reza Moradi, Davoud Ahmadvand
IntroductionModeling the blood-brain barrier has long been a challenge for pharmacological studies. Up to the present, numerous attempts have been devoted to recapitulating the endothelial barrier in vitro to assess drug delivery vehicles’ efficiency for brain disorders. In the current work, we presented a new approach for analyzing the morphometric parameters of the cells of an insert co-culture blood-brain