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Effective venetoclax-based treatment in relapsed/refractory multiple myeloma patients with translocation t(6;14). Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-11-10 Andrea Ceglédi,Zoltán Csukly,Mónika Fekete,András Kozma,Zsuzsanna Szemlaky,Hajnalka Andrikovics,Gábor Mikala
Introduction: The selective Bcl-2 inhibitor venetoclax has shown promising therapeutic potential in multiple myeloma, particularly in cases associated with t(11;14) IGH::CCND1 translocation. However, the efficacy of venetoclax in myeloma patients with the t(6;14) IGH::CCND3 translocation remains less investigated. Methods: In this study, we conducted a retrospective analysis to investigate the efficacy
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Expression of Concern: Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-11-09
[This corrects the article DOI: 10.3389/pore.2023.1611204.].
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Long term follow-up of refractory/relapsed hairy cell leukaemia patients treated with low-dose vemurafenib between 2013 and 2022 at the Department of Internal Medicine and Oncology, Semmelweis University. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-11-08 Kata Ferenczi,Zsófia Flóra Nagy,Ildikó Istenes,Hanna Eid,Csaba Bödör,Botond Timár,Judit Demeter
Introduction: Hairy cell leukemia (HCL) is an indolent B-cell lymphoproliferative disease. BRAF V600E mutation is detected in nearly all classical HCL cases which offers the possibility of targeted therapy. Objective: The aim of our study was to assess the efficacy of low-dose vemurafenib as well as to assess the long term outcome of HCL patients treated with this drug at the Department of Internal
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Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-10-18 Priyanka Verma,Bhavika Rishi,Noreen Grace George,Neetu Kushwaha,Himanshu Dhandha,Manpreet Kaur,Ankur Jain,Aditi Jain,Sumita Chaudhry,Amitabh Singh,Fouzia Siraj,Aroonima Misra
A class of exceptionally bioactive molecules known as reactive oxygen species (ROS) have been widely studied in the context of cancer. They play a significant role in the etiopathogenesis for cancer. Implication of ROS in cancer biology is an evolving area, considering the recent advances; insights into their generation, role of genomic and epigenetic regulators for ROS, earlier thought to be a chemical
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A new perspective on the proper timing of radiotherapy during CDK4/6 inhibitor therapy in patients with "bone-only" metastatic breast cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-10-11 Ilona Tornyi,Peter Árkosy,Ildikó Horváth,Andrea Furka
The vast majority of hormone positive and HER2 negative advanced breast cancers can be controlled well by endocrine therapy combined with the groundbreaking use of CDK4/6 inhibitors in the metastatic first-line setting. Approximately 50%-60% of these patients have "bone-only" metastatic disease. In oligometastatic cases or if a certain number of uncontrolled lesions develop during the aforementioned
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Concordance analysis of cerebrospinal fluid with the tumor tissue for integrated diagnosis in gliomas based on next-generation sequencing. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-09-26 Qiang Wang,Qiujin Liang,Wuting Wei,Wenhao Niu,Chong Liang,Xiaoliang Wang,Xiaoxuan Wang,Hao Pan
Purpose: The driver mutations of gliomas have been identified in cerebrospinal fluid (CSF). Here we compared the concordance between CSF and tumor tissue for integrated diagnosis in gliomas using next-generation sequencing (NGS) to evaluate the feasibility of CSF detection in gliomas. Patients and methods: 27 paired CSF/tumor tissues of glioma patients were sequenced by a customized gene panel based
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A unique case of AH-dominant type nodular pulmonary amyloidosis presenting as a spontaneous pneumothorax: a case report and review of the literature. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-09-22 Valeria Skopelidou,Pavel Hurník,Lubomír Tulinský,Vladimir Židlík,Jiří Lenz,Patricie Delongová,Helena Hornychová,Patrik Flodr,Tomáš Jelínek,Ludmila Muroňová,Dušan Holub,Petr Džubák,Marián Hajdúch
Amyloidosis is a rare metabolic disorder primarily brought on by misfolding of an autologous protein, which causes its local or systemic deposition in an aberrant fibrillar form. It is quite rare for pulmonary tissue to be impacted by amyloidosis; of the three forms it can take when involving pulmonary tissue, nodular pulmonary amyloidosis is the most uncommon. Nodular pulmonary amyloidosis rarely
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Case report: Clinical experience of treating pembrolizumab-induced systemic capillary leak syndrome (SCLS) in one patient with metastatic gastroesophageal junction squamous cell carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-09-08 Hua Ni,Xinjia Ding,Shikai Wu,Xuan Jin
Systemic capillary leak syndrome (SCLS) is a rare and complex adverse effect of immune checkpoint inhibitors (ICIs). The diagnosis of drug-induced SCLS is based on diffuse infusions of exudative fluid into the interstitial areas and the exclusion of other causes. The best management of ICIs-induced SCLS is not settled, though proper supportive care and corticosteroids were commonly applied as the first-line
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Active cancer as the main predictor of mortality for COVID-19 in oncology patients in a specialized center. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-09-07 Freddy Villanueva-Cotrina,Juan Velarde,Ricardo Rodriguez,Alejandra Bonilla,Marco Laura,Tania Saavedra,Diana Portillo-Alvarez,Yovel Bustamante,Cesar Fernandez,Marco Galvez-Nino
Introduction: The role of the type, stage and status of cancer in the outcome of COVID-19 remains unclear. Moreover, the characteristic pathological changes of severe COVID-19 reveled by laboratory and radiological findings are similar to those due to the development of cancer itself and antineoplastic therapies. Objective: To identify potential predictors of mortality of COVID-19 in cancer patients
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Patient delay and its clinical significance among head and neck cancer patients in Hungary. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-08-22 Kornél Dános,Angéla Horváth,Judit Halász,László Tamás,Gábor Polony
Introduction: Head and neck cancers represent a major health problem in Hungary. With their high incidence and mortality rates, Hungary is one of the world leaders in these indicators. The length of patient delay, defined as time from onset of symptoms to first medical consultation, is unknown in Hungarian patients with head and neck cancer. We aimed to use a representative sample of the Hungarian
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Obesity as a risk factor for multiple myeloma: insight on the role of adipokines. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-08-10 Wenting Tie,Tao Ma,Zhigang Yi,Jia Liu,Yanhong Li,Jun Bai,Lijuan Li,Liansheng Zhang
Multiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements
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Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-08-09 Marton Gyulai,Tunde Harko,Katalin Fabian,Luca Karsko,Laszlo Agocs,Balazs Szigeti,Janos Fillinger,Zoltan Szallasi,Orsolya Pipek,Judit Moldvay
Background: Although the expression of tight junction protein claudins (CLDNs) is well known in common histological subtypes of lung cancer, it has not been investigated in rare lung cancers. The aim of our study was to examine the expression of different CLDNs in pulmonary salivary gland tumors. Methods: 35 rare lung cancers including pathologically confirmed 12 adenoid cystic carcinomas (ACCs) and
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Fibroblast activation protein-α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-08-08 K Greimelmaier,N Klopp,E Mairinger,M Wessolly,S Borchert,J Steinborn,K W Schmid,J Wohlschlaeger,F D Mairinger
Background: Colorectal cancer (CRC) is still one of the leading causes of cancer death worldwide, emphasizing the need for further diagnostic and therapeutic approaches. Cancer invasion and metastasis are affected by the tumor microenvironment (TME), with cancer-associated fibroblasts (CAF) being the predominant cellular component. An important marker for CAF is fibroblast activation protein-α (FAP)
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Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-08-02 Massimiliano Cazzaniga,Giordano Bruno Zonzini,Francesco Di Pierro,Chiara Maria Palazzi,Marco Cardinali,Alexander Bertuccioli
Recent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of
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Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-07-14 Beryl Rabindran,Adriana D Corben
Introduction: The presence of positive margins following tumor resection is a frequent cause of re-excision surgery. Nondestructive, real-time intraoperative histopathological imaging methods may improve margin status assessment at the time of surgery; optical coherence tomography (OCT) has been identified as a potential solution but has not been tested with the most common tissue types in surgical
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Vitiligo-like lesions induced by cyclin-dependent kinase 4/6 inhibitor Palbociclib: a case report and literature review. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-07-06 Shan Gao,Guanjing Wei,Yanrong Hao
Endocrine therapy has played an essential role in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. With the continuous development of endocrine targeting drugs, especially the emergence of selective cyclin-dependent kinase (CDK4/6) inhibitors, the overall survival time in patients with HR+HER2- advanced breast cancer has been greatly improved
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Single-cell transcriptome analysis reveals the clinical implications of myeloid-derived suppressor cells in head and neck squamous cell carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-07-05 Wenru Jiang,Kangyao Hu,Xiaofei Liu,Jili Gao,Liping Zhu
Head and neck squamous cell carcinoma (HNSC) is the most common malignant tumor that arises in the epithelium of the head and neck regions. Myeloid-derived suppressor cells (MDSCs) are one of the tumor-infiltrating immune cell populations, which play a powerful role in inhibiting anti-tumor immune response. Herein, we employed a single-cell RNA sequencing (scRNA-seq) dataset to dissect the heterogeneity
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Efficacy of the low dose apatinib plus deep hyperthermia as third-line or later treatment in HER-2 negative advanced gastric cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-07-03 Guohu Han,Changchun Sun,Lihua Cui,Yufeng Huang,Lijiang Yu,Shenzha Liu,Min Tao
Aim: To observe the efficacy of the low dose apatinib plus deep hyperthermia as third-line or later treatment for patients with human epidermal growth factor receptor 2 (HER-2) negative advanced gastric cancer. Methods: 80 eligible patients with HER-2 negative advanced gastric cancer admitted to Jingjiang People's Hospital Affiliated with Yangzhou University-from March 2021 to March 2022 were selected
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Correlation analysis of circulating tumor cells and Claudin-4 in breast cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-07-03 Jie Chai,Xiangli Liu,Xinju Hu,Chunfang Wang
Objective: We aimed to explore the relationship between peripheral blood circulating tumor cells (CTCs) and the expression of Claudin-4 in patients with breast cancer, and further explore the potential impact on clinical prognosis and risk assessment. Methods: We classified and enumerated circulating tumor cells in the blood of breast cancer patients by CTC-enriched in situ hybridization and the detection
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Case report: Vulval sebaceous carcinoma: a report of two cases and literature review focus on treatment and survival. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-30 Xiaoxue Wang,Xin Wei
Background: Extraocular sebaceous carcinoma (SC) arising in the vulva is extremely rare that no treatment consensus has been well-defined. Case presentation: We here presented two cases of vulval SC in a 31-year-old and a 62-year-old woman, respectively. Radical wide local excision was performed with free margin and they received no postoperative adjuvant therapy. No evidence of disease was detected
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A combined approach for individualized lymphadenectomy in gastric cancer patients. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-29 Zsolt Varga,Adrienn Bíró,Miklós Török,Dezső Tóth
Introduction: Gastric cancer ranks as the fifth most common cancer globally. The presence of lymph node metastasis is a significant prognostic factor influencing survival. Postoperative morbidity and nodal staging accuracy are heavily affected by the extent of lymph node dissection. Our study aimed to explore the potential integration of two contemporary methods, sentinel node navigation surgery (SNNS)
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Prognostic value of pretreatment Controlling Nutritional Status score in esophageal cancer: a meta-analysis. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-27 Jing Lv,Peirui Chen,Jianqiang Wu,Caihong Hu
Background and purpose: The association between the pretreatment Controlling Nutritional Status (CONUT) score and the prognosis of esophageal cancer patients remains unclear. The aim of this meta-analysis was to further elucidate the prognostic role of the pretreatment CONUT score in esophageal cancer based on current evidence. Methods: The PubMed, Embase, Web of Science and CNKI databases were searched
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Three-dimensional analysis of perineural invasion in extrahepatic cholangiocarcinoma using tissue clearing. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-22 Hirokazu Ogasawara,Tadashi Yoshizawa,Kiyoko Oshima,Kenta Ogasawara,Shunsuke Kubota,Shintaro Goto,Satoko Morohashi,Taiichi Wakiya,Norihisa Kimura,Keinosuke Ishido,Hiroshi Kijima,Kenichi Hakamada
Perineural invasion (PNI) is a characteristic invasion pattern of distal cholangiocarcinoma (DCC). Conventional histopathologic examination is a challenging approach to analyze the spatial relationship between cancer and neural tissue in full-thickness bile duct specimens. Therefore, we used a tissue clearing method to examine PNI in DCC with three-dimensional (3D) structural analysis. The immunolabeling-enabled
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Grade Group accuracy is improved by extensive prostate biopsy sampling, but unrelated to prostatectomy specimen sampling or use of immunohistochemistry. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-21 Kristóf Levente Korpás,Lívia Beke,Dániel Varga,László Bidiga,Gábor Méhes,Sarolta Molnár
Assessing the accurate Grade Group of a prostate needle biopsy specimen is essential for choosing the adequate therapeutic modality for prostate cancer patients. However, it is well-known that biopsy Grade Group tends to up- or downgrade significantly at radical prostatectomy. We aimed to investigate the correlation between accuracy and biopsy core number, performed immunohistochemical staining (IHC)
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Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-12 Letian Zhang,Pei Yuan,Qi Cao,Jiali Mu,Jianming Ying,Changyuan Guo
Tumor-to-tumor metastasis is a rare phenomenon. Although renal cell carcinoma is the most common recipient tumor, metastatic lobular breast carcinoma to clear cell renal cell carcinoma is even rarer, with only one case reported to date. We present a 66-year-old female patient with an invasive lobular carcinoma history who was admitted to the hospital with a right renal mass. The patient received partial
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Tumor subtypes and signature model construction based on chromatin regulators for better prediction of prognosis in uveal melanoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-09 Yue Li,Chao Xiong,Li Li Wu,Bo Yuan Zhang,Sha Wu,Yu Fen Chen,Qi Hua Xu,Hong Fei Liao
Background: Uveal Melanoma (UM) is the most prevalent primary intraocular malignancy in adults. This study assessed the importance of chromatin regulators (CRs) in UM and developed a model to predict UM prognosis. Methods: Gene expression data and clinical information for UM were obtained from public databases. Samples were typed according to the gene expression of CRs associated with UM prognosis
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Case Report: Brainstem angiocentric glioma presenting in a toddler child-diagnostic and therapeutic challenges. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-09 Zita Reisz,Bence Laszlo Radics,Peter Nemes,Ross Laxton,Laszlo Kaizer,Krisztina Mita Gabor,Timea Novak,Pal Barzo,Safa Al-Sarraj,Istvan Bodi
Introduction: Angiocentric gliomas (AG) in brainstem location are exceedingly rare and might cause differential diagnostic problems and uncertainty regarding the best therapeutic approach. Hereby, we describe the clinicopathological findings in a brainstem AG presenting in a toddler child and review the literature. Case report: A 2-year-old boy presented with 5 weeks history of gait disturbances, frequent
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CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-07 Lifen Shen,Yen-Ling Chen,Chu-Chun Huang,Yu-Chiau Shyu,Richard E B Seftor,Elisabeth A Seftor,Mary J C Hendrix,Du-Shieng Chien,Yi-Wen Chu
CVM-1118 (foslinanib) is a phosphoric ester compound selected from 2-phenyl-4-quinolone derivatives. The NCI 60 cancer panel screening showed CVM-1125, the major active metabolite of CVM-1118, to exhibit growth inhibitory and cytotoxic effects at nanomolar range. CVM-1118 possesses multiple bioactivities, including inducing cellular apoptosis, cell cycle arrest at G2/M, as well as inhibiting vasculogenic
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Cytokine-induced killer cell treatment is superior to chemotherapy alone in esophageal cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-05 Jiayang Sun,Yushu Sun,Miniderima,Xiumei Wang
Background: The therapeutic efficacy of cytokine-induced killer (CIK) cells versus dendritic cells (DC) co-cultured with CIK cells (DC-CIK) in treating esophageal cancer (EC) remains unclear due to the absence of a direct comparison of these two regimens. This study evaluated the comparative efficacy and safety of CIK cells versus DC-CIK using network meta-analysis in treating EC. Material and methods:
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Association between radiomics features of DCE-MRI and CD8+ and CD4+ TILs in advanced gastric cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-05 Huizhen Huang,Zhiheng Li,Yue Xia,Zhenhua Zhao,Dandan Wang,Hongyan Jin,Fang Liu,Ye Yang,Liyijing Shen,Zengxin Lu
Objective: The aim of this investigation was to explore the correlation between the levels of tumor-infiltrating CD8+ and CD4+ T cells and the quantitative pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced gastric cancer. Methods: We retrospectively analyzed the data of 103 patients with histopathologically confirmed advanced gastric
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Delayed spontaneous remission of acquired factor V inhibitor refractory to immunosuppressive therapy with pregnancy-associated improvement. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-02 Andrea Ceglédi,János Dolgos,Mónika Fekete,László Gopcsa,Andrea Várkonyi,Beáta Vilimi,Gábor Mikala,Imre Bodó
Introduction: Acquired factor V inhibitor (AFVI) is a rare autoimmune bleeding disorder. The treatment of AFVI is challenging, and patients often require both bleeding control and inhibitor eradication. Methods: We conducted a retrospective analysis of the medical records of a 35-year-old Caucasian woman who presented with severe AFVI-induced bleeding and subsequent immunosuppressive therapy. Results:
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Integrated oxidative stress score for predicting prognosis in stage III gastric cancer undergoing surgery. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-02 Yu-Hang Liu,Rui Meng,Bing Zhu,Qi-Qi Zhan,Xin Yang,Guan-Yi Ding,Chun-Liang Jia,Qian-Yu Liu,Wei-Guo Xu
Objective: This study aimed to develop a novel scoring system, named the integrated oxidative stress score (IOSS), based on oxidative stress indices to predict the prognosis in stage III gastric cancer. Methods: Retrospective analysis of stage III gastric cancer patients who were operated on between January 2014 and December 2016 were enrolled into this research. IOSS is a comprehensive index based
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Expression of aquaporin 1, 3 and 5 in colorectal carcinoma: correlation with clinicopathological characteristics and prognosis. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-06-02 Guangwen Zhang,Yongfei Hao,Ling Chen,Zengshan Li,Langlang Gao,Jian Tian,Qing Qiao,Jinsong Zhang
Background: Prognostic biomarkers in colorectal carcinoma (CRC) have an important role in therapeutic strategy. Studies have shown that high expression of Aquaporin (AQP) is associated with poor prognosis in a variety of human tumors. AQP is involved in the initiation and development of CRC. The present study aimed to investigate the correlation between the expression of AQP1, 3 and 5 and clinicopathological
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Potential predictors for CDX2 expression loss and mismatch repair deficiency in colorectal cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-31 Ivan Vlahović,Jasmina Rajc,Ivan Švagelj,Krešimir Šolić,Dražen Švagelj
CDX2 expression loss is commonly associated with mismatch repair deficiency (dMMR) in colorectal cancer (CRC). However, there are only a few studies that have attempted to correlate CDX2 expression loss with specific MMR genes (MLH1, MSH2, MSH6, PMS2). This is a retrospective study of 327 patients who underwent surgery due to CRC. Nine patients (2.9%) had two synchronous CRCs, making the total sample
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Prognostic value of albumin-bilirubin score in pancreatic cancer patients after pancreatoduodenectomy with liver metastasis following radiofrequency ablation. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-30 Lei Zhang,Xuefei Zhang,Bolin Wu,Xue Han,Cunli Guo,Bo Li,Hui Jing,Wen Cheng
Objective: The current study aimed to investigate the prognostic value of albumin-bilirubin (ALBI) score in predicting clinical outcomes of pancreatic cancer patients after pancreatoduodenectomy with liver metastasis following radiofrequency ablation. Methods: This retrospective study included 90 pancreatic cancer patients after pancreatoduodenectomy with liver metastasis from January 2012 to December
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Immunohistochemistry-based molecular subtyping of triple-negative breast cancer and its prognostic significance. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-19 Marisa Leeha,Kanyanatt Kanokwiroon,Suphawat Laohawiriyakamol,Paramee Thongsuksai
Background: Immunohistochemistry (IHC)-based protein markers representing molecular subtypes are of great value for routine use. This study aimed to evaluate the frequency distributions of the molecular subtypes of triple-negative breast cancer (TNBC) using IHC-based surrogate markers and examined their prognostic value. Methods: Patients with TNBC treated at a university hospital in Southern Thailand
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PD-1 and PD-L1 expression in rare lung tumors. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-18 Marton Gyulai,Zsolt Megyesfalvi,Lilla Reiniger,Tunde Harko,Bence Ferencz,Luca Karsko,Laszlo Agocs,Janos Fillinger,Balazs Dome,Zoltan Szallasi,Judit Moldvay
Background: Our knowledge is still limited about the characteristics and treatment of rare lung tumors. The aim of our study was to determine programmed cell death ligand-1 (PD-L1) and programmed cell death-1 (PD-1) expression in rare pulmonary tumors to assess the potential role of immunotherapy. Methods: 66 pathologically confirmed rare lung tumors including 26 mucoepidermoid carcinomas (MECs), 27
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Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-18 Kyung Bin Kim,Ji Hyun Ahn,Soon Wook Kwon,Su Ji Lee,Yury Lee,Seo Young Park,Ahrong Kim,Kyung Un Choi,Chang Hun Lee,Gi Yeong Huh
Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters. Methods: We
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Correlations between the histopathological alterations in minor salivary glands and the clinically suspected Sjögren's syndrome. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-15 Mária Janka,Attila Zalatnai
In sicca syndrome patients the xerostomia, xerophthalmia and the serological findings may strongly suggest the autoimmune Sjögren's syndrome, but the histological findings in the labial salivary gland biopsies do not always justify the suspected diagnosis. The aim of this study was to compare the histomorphological changes and the clinical findings in patients with pathologically established Sjögren's
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Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-12 Wen Han,Bei Wang,Xiang Yong,Yi Zhang,Mingyu Shao,Chun Wang
Objective: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic disease with an indolent clinical course, manifesting as hyperplasia of immature extrathymic T-lymphoblastic cells. Isolated iT-LBP has been observed, but the majority of iT-LBP cases has been seen in conjunction with other diseases. iT-LBP is easily misdiagnosed as T-lymphoblastic lymphoma/leukemia, and understanding the
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A case report of recurrent leiomyosarcoma with chondrosarcoma differentiation in the abdominal wall and a review of the literature. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-10 Xuan Zuo,Wei L Wu,Peng Shi,Tian M Liu,Na Yu,Lei Li
Leiomyosarcoma with heterologous differentiation is relatively rare. To date, only 19 cases have been reported in the English literature. Heterologous components frequently show histological pleomorphism, while those exhibiting well-differentiated morphology are seldom reported. Here, we report a 34-year-old female diagnosed with leiomyosarcoma and developed abdominal wall recurrence 8 years after
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Potential predictors of immunotherapy in small cell lung cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-05-03 Valeria Skopelidou,Jan Strakoš,Jozef Škarda,Milan Raška,Leona Kafková-Rašková
Lung cancer is one of the leading causes of cancer-related deaths worldwide, with small cell lung cancer (SCLC) having the worst prognosis. SCLC is diagnosed late in the disease's progression, limiting treatment options. The most common treatment for SCLC is chemotherapy. As the disease progresses, immunotherapy, most commonly checkpoint inhibitor medication, becomes more important. Efforts should
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Soluble B-cell maturation antigen as a monitoring marker for multiple myeloma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-28 Ádám Wiedemann,Virág Réka Szita,Róbert Horváth,Attila Szederjesi,Attila Sebő,András Dávid Tóth,Tamás Masszi,Gergely Varga
Objective: Response to treatment in multiple myeloma (MM) is routinely measured by serum and urine M-protein and free light chain (FLC), as described by the International Myeloma Working Group (IMWG) consensus statement. A non-negligible subgroup of patients however present without measurable biomarkers, others become oligo or non-secretory during recurrent relapses. The aim of our research was to
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RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-28 Thitima Khonrak,Sasithorn Watcharadetwittaya,Yaovalux Chamgramol,Piyapharom Intarawichian,Raksawan Deenonpoe
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The RET gene rearrangements CCDC6::RET and NCOA4::RET are the most common RET gene rearrangements in PTC patients. Different RET::PTC rearrangements are associated with different PTC phenotypes. Methods: Eighty-three formalin-fixed paraffin-embedded (FFPE) PTC samples were examined. The prevalence and expression
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The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-24 Mónika Révész,Ferenc Oberna,András Slezák,Örs Ferenczi,István Kenessey,Zoltán Takácsi-Nagy
We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000-2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient's medical records were collected from the institutional database. The prevalence of smoking and alcohol consumption
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Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-24 Hui Li,Chenbo Yang,Kuisheng Chen,Miaomiao Sun
Despite significant advances in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC), esophageal cancer is still a heavy social and medical burden due to its high incidence. Uncontrolled division and proliferation is one of the characteristics of tumor cells, which will promote rapid tumor growth and metastasis. Early mitotic inhibitor 1 (Emi1), ubiquitin-conjugating enzyme 10 (UBCH10)
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Prognostic role of pretreatment skeletal muscle index in gastric cancer patients: A meta-analysis. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-24 Xiaohong He,Sicheng Zhou,Hongjun Li,Yue Gou,Dan Jia
Background: The association between pretreatment skeletal muscle index (SMI) and long-term survival of gastric cancer patients remains unclear up to now. The aim of this meta-analysis was to identify the prognostic value of pretreatment SMI in gastric cancer. Methods: The PubMed, EMBASE and Web of Science electronic databases were searched up to 5 June 2022 for relevant studies. The primary outcome
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Correlation between fibroblast growth factor receptor mutation, programmed death ligand-1 expression and survival in urinary bladder cancer based on real-world data. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-21 Janos Revesz,Boglarka Posfai,Laszlo Pajor,Timea Papdan,Linda Varga,Viktor R Paczona,Zoltan Varga,Farkas Sukosd,Aniko Maraz
Background: Programmed cell death (PD)-1/PD-ligand 1 (PD-L1) inhibitors have made a breakthrough in the therapy of advanced urothelial bladder cancer (UBC). The impact of Fibroblast Growth Factor Receptor 3 (FGFR3) mutation on the effectiveness of PD-L1 treatment remains still unclear. Objective: Our study aimed to investigate the frequency of FGFR mutations at different tumor stages, and their relation
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Characterization of the input material quality for the production of tisagenlecleucel by multiparameter flow cytometry and its relation to the clinical outcome. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-20 Martin Štach,Robert Pytlík,Kristýna Šmilauerová,Jana Rychlá,Martin Mucha,Jan Musil,Abhishek Koladiya,Matěj Nemec,Martina Petráčková,Iva Kaštánková,Pavla Pecherková,Lucie Šrámková,Kamila Polgárová,Marek Trněný,Petr Lesný,Jan Vydra,Pavel Otáhal
Tisagenlecleucel (tisa-cel) is a CD19-specific CAR-T cell product approved for the treatment of relapsed/refractory (r/r) DLBCL or B-ALL. We have followed a group of patients diagnosed with childhood B-ALL (n = 5), adult B-ALL (n = 2), and DLBCL (n = 25) who were treated with tisa-cel under non-clinical trial conditions. The goal was to determine how the intensive pretreatment of patients affects the
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Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenström macroglobulinemia during treatment with BTK inhibitors. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-19 Jingjing Zhu,Xinyu Zhu,Fengyang Xie,Yi Ding,Huina Lu,Yan Dong,Ping Li,Jianfei Fu,Aibin Liang,Yu Zeng,Bing Xiu
Background: Waldenström macroglobulinemia (WM) is a rare subtype of B-cell lymphoma. Rituximab-based combination therapy and Bruton's tyrosine kinase (BTK) inhibitors have greatly improved the prognosis of WM. Despite the high response rate and good tolerance of BTK inhibitors in treatment of WM, a proportion of patients still experience disease progression. Case presentation: We report a 55-year-old
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Development and validation of a prognostic nomogram for rectal cancer patients who underwent surgical resection. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-19 Bochao Zhao,Jingchao Wang,Zhicheng Ma,Haikun Ye,Tao Yang,Kewei Meng
Objective: The purpose of this study was to develop and validate a nomogram model for the prediction of survival outcome in rectal cancer patients who underwent surgical resection. Methods: A total of 9,919 consecutive patients were retrospectively identified using the Surveillance, Epidemiology, and End Results (SEER) database. Significant prognostic factors were determined by the univariate and multivariate
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Identification and validation of molecular subtype and prognostic signature for lung adenocarcinoma based on neutrophil extracellular traps. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-18 Yanhua Zuo,Guangyi Leng,Ping Leng
Background: Neutrophil Extracellular Traps (NETs) are fibrous networks made of DNA-histone complexes and proteins protruded from activated neutrophils. Accumulating evidences have highlighted the vital role of NETs in tumor progression and diffusion. However, limited systematic studies regarding the role of NETs in LUAD have been performed. Methods: Differentially expressed NETs-related genes and their
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Tumor PD-L1 expression and molecular profiling are not associated with immune checkpoint inhibitor-induced thyroid dysfunction in advanced NSCLC patients. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-17 Adi Horesh,Rena Pollack,Hovav Nechushtan,Rivka Dresner-Pollak,Tzahi Neuman
Background: Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC), however are frequently associated with thyroid immune-related adverse events (IRAEs). We investigated the association between patient characteristics, tumor PD-L1 expression and molecular profile with the development of thyroid IRAEs in NSCLC patients. Methods: Single center
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Increased Kremen2 predicts worse prognosis in colon cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-12 Junxian Long,Fengyun Cong,Yousheng Wei,Jungang Liu,Weizhong Tang
Background: Colon cancer (CC) is the fifth most prevalent cancer around the globe and poses a major risk to human health. Even though Kremen2 serves as a prognostic indicator in individuals with malignant tumours, its role in evaluating the prognosis of individuals with colon cancer has not been confirmed. Methods: Here, we examined the protein expression of Kremen2 in CC tissues and paired adjacent
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Predicting prognosis and clinical efficacy of immune checkpoint blockade therapy via interferon-alpha response in muscle-invasive bladder cancer. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-04 Bohan Fan,Xin Zheng,Yicun Wang,Xiaopeng Hu
Background: Immune checkpoint blockade (ICB) can prompt durable and robust responses in multiple cancers, involving muscle-invasive bladder cancer (MIBC). However, only a limited fraction of patients received clinical benefit. Clarifying the determinants of response and exploring corresponding predictive biomarkers is key to improving outcomes. Methods: Four independent formerly published cohorts consisting
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Editorial: In vivo and in vitro models for research in pathology. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-04-04 Songwen Tan,Peter Nemeth
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CircRNA: A new class of targets for gastric cancer drug resistance therapy. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-03-30 Ying Zheng,Zhe Li,Yao Wang,Wanjiao Chen,Yifan Lin,Junming Guo,Guoliang Ye
Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and pemetrexed, as well as targeted agents. However, the emergence of drug resistance evidence in poor patient outcomes and poor prognosis is a motivation to
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Editorial: Liquid biopsy-A great hope or just hype? Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-03-28 Aleš Ryška
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Screening of core genes and prediction of ceRNA regulation mechanism of circRNAs in nasopharyngeal carcinoma by bioinformatics analysis. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-03-28 HongMin Chen,XiaoXiao Shi,Li Ren,YuMing Wan,HongYu Zhuo,Li Zeng,WangMu SangDan,Feng Wang
Background: Nasopharyngeal carcinoma (NPC) represents a highly aggressive malignant tumor. Competing endogenous RNAs (ceRNA) regulation is a common regulatory mechanism in tumors. The ceRNA network links the functions between mRNAs and ncRNAs, thus playing an important regulatory role in diseases. This study screened the potential key genes in NPC and predicted regulatory mechanisms using bioinformatics
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LAMP5 may promote MM progression by activating p38. Pathol. Oncol. Res. (IF 2.8) Pub Date : 2023-03-22 Yan Chen,Tao Ma
Multiple myeloma (MM) is the second most common tumor of the hematologic system. MM remains incurable at this time. In this study, we used bioinformatics analysis to find key genes in the pathogenesis of MM. We first found that Lysosome associated membrane protein 5 (LAMP5) expression was sequentially increased in healthy donors (HD), monoclonal gammopathy of undetermined significance (MGUS), smoldering