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HAND2-AS1 Promotes Ferroptosis to Reverse Lenvatinib Resistance in Hepatocellular Carcinoma by TLR4/NOX2/DUOX2 Axis Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-03-11 Zheng Song, Yu Zhang, Wei Luo, Chao Sun, Caihong Lv, Sihao Wang, Quanwei He, Ran Xu, Zhaofang Bai, Xiujuan Chang, Yongping Yang
Introduction: Lenvatinib resistance causes less than 40% of the objective response rate. Therefore, it is urgent to explore new therapeutic targets to reverse the lenvatinib resistance for HCC. HAND2-AS1 is a critical tumor suppressor gene in various cancers. Methods: Here, we investigated the role of HAND2-AS1 in the molecular mechanism of lenvatinib resistance in HCC. It was found that HAND2-AS1
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Twenty-four-month Progression-free Survival in HER2-amplified Advanced Gastric Cancer with Brain Metastases after Trastuzumab Deruxtecan Treatment: A Case Report and Literature Review Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-03-11 Haibo Zhang, Min Xu
Background: Trastuzumab deruxtecan (T-DXd) has shown promising outcomes as a second or subsequent-line treatment for human epidermal growth factor-2 (HER2)-positive advanced gastric or gastroesophageal junction cancer. Case Presentation: We reported a 49-year-old male patient with stage IV HER2-amplified gastric cancer. Despite extensive pretreatments, including first-line trastuzumab plus FOLFOX,
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A Review on Patient-Derived 3D Micro Cancer Approach for Drug Screen in Personalized Cancer Medicine Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-03-06 Zülal Atlı Şekeroğlu, Vedat Şekeroğlu
: Precision medicine in oncology aims to identify an individualized treatment plan based on genomic alterations in a patient’s tumor. It helps to select the most beneficial therapy for an individual patient. As it is now known that no patient's cancer is the same, and therefore, different patients may respond differently to conventional treatments, precision medicine, which replaces the one-size-fits-all
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DNA Methylation-Based Diagnosis and Treatment of Breast Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-03-05 Xintong Peng, Jingfan Zheng, Tianzi Liu, Ziwen Zhou, Chen Song, Danyan Zhang, Xinlong Zhang, Yan Huang
: DNA methylation is a key epigenetic modifier involved in tumor formation, invasion, and metastasis. The development of breast cancer is a complex process, and many studies have now confirmed the involvement of DNA methylation in breast cancer. Moreover, the number of genes identified as aberrantly methylated in breast cancer is rapidly increasing, and the accumulation of epigenetic alterations becomes
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TBOPP, a DOCK1 Inhibitor, Potentiates Cisplatin Efficacy in Breast Cancer by Regulating Twist-mediated EMT Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-03-01 Xin Chen, Zhenbang Zhou, Pengting Tang, Feiya Du, Shuqian Wang, Jia Yao, Shufen Zhang, Jiajing Huang, Xuemei Lu, Wei Chen, Xiaofang Yu, Yu Liu, Hao Liu
Background: DOCK1 has been reported to be involved in tumor progression and resistance. 1-(2-(30-(trifluoromethyl)-[1,10-biphenyl]-4-yl)-2-oxoethyl)-5-pyrrolidinylsulfonyl2(1H)- pyridone (TBOPP) is a selective DOCK1 inhibitor; however, the role and molecular mechanisms of DOCK1 and its inhibition in breast cancer (BC) resistance remain poorly understood. Objective: This study aims toinvestigate the
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The Prognostic Value and Clinical Significance of lncRNA SNHG5 Expression in Patients with Multiple Malignancies: A Bioinformatic and Meta-Analysis Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-27 Mehran Pashirzad, Amirhossein Sahebkar
Background:: Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5) has been identified as both a promising target for treatment and a predictor of prognosis in diverse types of cancer. The objective of this study was to assess whether lncRNA SNHG5 expression can be utilized as a prognostic biomarker for human cancer. Methods:: To ensure a thorough search of the literature for relevant
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An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-27 Pooja Jain, Sradhanjali Mohapatra, Uzma Farooq, Nazia Hassan, Mohd. Aamir Mirza, Zeenat Iqbal
: It is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development
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Thyroid Metastases from Breast Cancer Case Report and Literature Review Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-27 Yumei Guan, Qinjun Ma, Yiqing Zhang, Jiuda Zhao, Xinjian Guo
Background: Thyroid metastasis arising from primary breast cancer is a rare phenomenon, with only a handful of cases documented in both national and international literature. The management approach and prognosis of this occurrence have sparked debates and uncertainties. Case Presentation: Herein, we report the case of a 55-year-old woman with breast cancer. She previously underwent extensive excision
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Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-22 Magham Sai Varshini, Praveen Thaggikuppe Krishnamurthy, Ramakamma Aishwarya Reddy, Ashish Wadhwani, V.M. Chandrashekar
: Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, is characterized by the non-appearance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Clinically, TNBC is marked by its low survival rate, poor therapeutic outcomes, high aggressiveness, and lack of targeted therapies. Over the past few decades, many clinical
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Construction of an Oxidative Stress Risk Model to Analyze the Correlation Between Liver Cancer and Tumor Immunity Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-20 Ying Liu, Yufeng Li, Li Chen, Weina Zha, Jing Zhang, Kun Wang, Chunhai Hao, Jianhe Gan
Background:: Hepatocellular carcinoma (HCC) remains one of the most lethal cancers globally. Despite advancements in immunotherapy, the prognosis for patients with HCC continues to be poor. As oxidative stress plays a significant role in the onset and progression of various diseases, including metabolism-related HCC, comprehending its mechanism in HCC is critical for effective diagnosis and treatment
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The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-16 Shiqi Dong, Chao Chen, Chang Di, Shufan Wang, Quan Dong, Wenxin Lin, Duo Liu
: NADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress response of the body. NADPH 9 oxidase 2 (NOX2) is the first and most representative member of the NADPH oxidase family, and its effects on the development of tumor cells are gaining more and more attention. Our previous study suggested that NCF4 polymorphism
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Effects of HSV-G47Δ Oncolytic Virus on Telomerase and Telomere Length Alterations in Glioblastoma Multiforme Cancer Stem Cells Under Hypoxia and Normoxia Conditions Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-15 Reza Vazifehmand, Dhuha Saeed Ali, Foroozandeh Monem Homaie, Fateme Molaei Jalalvand, Zulkefley Othman, Chau Deming, Johnson Stanslas, Zamberi Sekawi
Background: Due to the existence of tumor stem cells with tumorigenicity properties and resistance patterns, treatment of glioblastoma is not easy. Hypoxia is a major concern in glioblastoma therapy. Telomerase activity and telomere length alterations have been known to play a critical role in glioblastoma progression and invasion. Objective: This study aimed to investigate the effects of HSV-G47Δ
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Stabilizing Scaffold for Short Peptides Based on Knottins Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-15 Evgenii Beloborodov, Elena Iurova, Dmitrii Sugak, Eugenia Rastorgueva, Evgeniya Pogodina, Aleksandr Fomin, Denis Viktorov, Sergei Slesarev, Yury Saenko
Background: Bombesin (BBN) is a short peptide with a high affinity for receptors that are expressed on the surface of various types of cancer cells. However, a full length BBN molecule has low in vivo stability. background: Bombesin is a short peptide with high affinity for a receptor that is expressed on the surface of various types of cancer cells. However, the full length BBN molecule has low in
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The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-13 Rozita Khodashahi, Fatemeh Beiraghdar, Gorgon A Ferns, Kiayash Ashrafzadeh, Mohsen Aliakbarian, Mohammad-Hassan Arjmand
abstract: Obesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose
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Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, Thereby Promoting Angiogenesis in Hepatocellular Carcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-13 Fabiao Zhang, Binfeng Wang, Wenlong Zhang, Yongfu Xu, Caiming Zhang, Xiangyang Xue
Background: Hepatocellular carcinoma (HCC) is characterized by high vascularity and notable abnormality of blood vessels, where angiogenesis is a key process in tumorigenesis and metastasis. The main functions of Nei Like DNA Glycosylase 3 (NEIL3) include DNA alcoholization repair, immune response regulation, nervous system development and function, and DNA damage signal transduction. However, the
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H3K27ac-activated LncRNA NUTM2A-AS1 Facilitates the Progression of Colorectal Cancer Cells via MicroRNA-126-5p/FAM3C Axis Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-13 Haiguan Lin, Shidong Hu, Yuxuan Li, Songyan Li, Da Teng, Yan Yang, Boyan Liu, Xiaohui Du
Objective: Long non-coding RNAs (lncRNAs) are of great importance in the process of colorectal cancer (CRC) tumorigenesis and progression. However, the functions and underlying molecular mechanisms of the majority of lncRNAs in CRC still lack clarity. background: Long non-coding RNAs (lncRNAs) are great of importance in the process of colorectal cancer (CRC) tumorigenesis and progression. Methods:
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Dauricine Inhibits Non-small Cell Lung Cancer Development by Regulating PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2 Pathways in a FLT4-dependent Manner Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-07 Jinna Liang, Panpan Lei, Xinyue Su, Jiapan Gao, Bingxi Ren, Yuxiu Zhang, Xiaoyu Ma, Weina Ma
Objective: Non-small cell lung cancer (NSCLC) is still a solid tumor with high malignancy and poor prognosis. Vascular endothelial growth factor receptor 3 (FLT4, VEGFR3) is overexpressed in NSCLC cells, making it a potential target for NSCLC treatment. In this study, we aimed to explore the anti-cancer effects of dauricine on NSCLC cells and its mechanism targeting FLT4. Methods: We found that dauricine
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Hybrid Nanoparticle for Co-delivering Paclitaxel and Dihydroartemisinin to Exhibit Synergic Anticancer Therapeutics Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-07 Bao Ngoc Tran, Thu Thi Kim Ninh, Thao Thi Do, Phuong Thi Do, Chien Ngoc Nguyen
Aim: Anticancer treatment is required to provide effective and safe patient medicines. This research aided in developing and applying nanoparticles (NPs) for cancer treatment. Background: The poor solubility of paclitaxel (PTX) restricts its therapeutic efficacy because of allergic side effects caused by formulation excipients. To overcome this, PTX was coupled with artemisinin derivatives and loaded
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Research Progress of PD 1/PD L1 Inhibitors in the Treatment of Urological Tumors Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-06 Lv Han, Yang Meng, Zhu Jianguo
abstract: Immune checkpoint inhibitors (ICIs) offer significant advantages for the treatment of urologic tumors, enhancing the immune function of anti-tumor T cells by inhibiting PD-1 and PDL1 binding. They have been shown to be well tolerated and remarkably effective in clinical practice, offering hope to many patients who are not well treated with conventional drugs. Clinical trials in recent years
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Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-06 Fereshte Ghorbani, Afrooz Mazidimoradi, Arezou Biyabani, Leila Allaqoli, Hamid Salehiniya
: Most cancer deaths are related to gastrointestinal (GI) cancers. Several environmental and genetic factors are effective in the occurrence of GI cancers, such as esophageal, stomach, colorectal, liver, and pancreatic cancers. In addition to risk factors related to lifestyle, reactive oxygen species (ROS) also play a role in GI cancers, and an increase in the amount of free radicals can lead to oxidative
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Effect of Neoadjuvant Immunotherapy Combined with Chemotherapy on Pulmonary Function and Postoperative Pulmonary Complications in Esophageal Cancer: A Retrospective Study Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-04 Yongyin Gao, Hongdian Zhang, Yanli Qiu, Xueyan Bian, Xue Wang, Yue Li
Results: The FEV1% pred, FVC, FVC% pred, and FEV1/FVC% significantly increased after NICT, with a P-value of 0.018, 0.005, 0.001, and 0.036, respectively. In contrast, there was a significant decline in the DLCO (8.92 ± 2.34 L before NICT vs. 7.79 ± 2.30 L after NICT; P < 0.05) and DLCO% pred (102.97 ± 26.22% before NICT vs. 90.18 ± 25.04% after NICT; P < 0.05). High DLCO and DLCO% pred at baseline
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Brucine Inhibits Proliferation of Pancreatic Ductal Adenocarcinoma through PI3K/AKT Pathway-induced Mitochondrial Apoptosis Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-04 You Wu, Feng Zhang, Panling Xu, Ping Li
Introduction: The purpose of this research was to settle the role of brucine in pancreatic ductal adenocarcinoma (PDAC) and the mechanisms involved. Methods: The findings of this study suggest that brucine exerts inhibitory effects on cell growth, clonogenicity, and invasive potential of Panc02 and Mia Paca-2 cells. These effects may be linked to an increase in apoptotic-prone cell population. Results:
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The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-04 Reza Karbalaee, Saber Mehdizadeh, Hadi Esmaeili Gouvarchin Ghaleh, Morteza Izadi, Bahman Jalali kondori, Ruhollah Dorostkar, Seyed Morteza Hosseini
Background: Cancer is a major cause of death worldwide. Colorectal cancer is the second most common type. Additional treatments like chemotherapy and radiation therapy may be recommended. Developing new techniques is vital due to drug resistance and a lack of targeted therapies. Objective: In this study, the effects of mesenchymal stem cells (MSCs) loaded with oncolytic Coxsackievirus A21 (CVA21) on
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Development of Chromatin Regulator-related Molecular Subtypes and a Signature to Predict Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-04 Juntao Huang, Ziqian Xu, ZhenZhen Wang, Chongchang Zhou, Yi Shen
Background: Chromatin regulators (CRs) serve as indispensable factors in tumor biological processes by influencing tumorigenesis and the immune microenvironment and have been identified in head and neck squamous cell carcinoma (HNSCC). Hence, CR-related genes (CRRGs) are considered potential biomarkers for predicting prognosis and immune infiltration in HNSCC. In this study, we established a novel
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Cuproptosis Related Gene DLD Associated with Poor Prognosis and Malignant Biological Characteristics in Lung Adenocarcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-04 Xinyang Li, Junshuai Rui, Zihan Yang, Feng Shang-guan, Haolin Shi, Dengkui Wang, Jiachun Sun
Purpose: Cuproptosis plays a crucial role in the biological function of cells. The subject of this work was to analyze the effects of cuproptosis-related genes (CRGs) on the prognosis and biological function in lung adenocarcinoma (LUAD). background: Cuproptosis, as a newly discovered cell metabolism mode, plays a crucial role in the biological function of cells. Methods: In this study, RNA sequencing
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A Novel Oncogenic Role of Disulfidptosis-related Gene SLC7A11 in Anti--tumor Immunotherapy Response to Human Cancers Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-02 Borui Xu, Jiahua Liang, Liangmin Fu, Juan Lin, Jinhuan Wei
Background: The protein Solute Carrier Family 7 Member 11 (SLC7A11) plays a pivotal role in cellular redox homeostasis by suppressing disulfidptosis, which restricts tumor growth. Yet, its relevance in prognosis, immunity, and cancer treatment efficacy is not well understood. Methods: We conducted a comprehensive analysis of the expression of SLC7A11 across 33 cancer types, employing datasets from
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Repurposing of Antidiarrheal Loperamide for Treating Melanoma by Inducing Cell Apoptosis and Cell Metastasis Suppression In Vitro and In Vivo Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-02 Shuping Yang, Zhi Li, Mingyue Pan, Jing Ma, Zeyu Pan, Peng Zhang, Weiling Cao
Background: Melanoma is the most common skin tumor worldwide and still lacks effective therapeutic agents in clinical practice. Repurposing of existing drugs for clinical tumor treatment is an attractive and effective strategy. Loperamide is a commonly used anti-diarrheal drug with excellent safety profiles. However, the affection and mechanism of loperamide in melanoma remain unknown. Herein, the
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Curcumin Inhibits Vasculogenic Mimicry Via Regulating ETS-1 in Renal Cell Carcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Yue Chong, Shan Xu, Tianjie Liu, Peng Guo, Xinyang Wang, Dalin He, Guodong Zhu
Background: Metastatic renal cell carcinoma (RCC) poses a huge challenge once it has become resistant to targeted therapy. Vasculogenic mimicry (VM) is a novel blood supply system formed by tumor cells that can circumvent molecular targeted therapies. As one of the herbal remedies, curcumin has been demonstrated to play antineoplastic effects in many different types of human cancers; however, its function
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Neuronatin Promotes the Progression of Non-Small Cell Lung Cancer by Activating the NF-κB Signaling Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Huanwen Xiong, Guohua Chen, Ke Fang, Weiguo Gu, Feng Qiu
Background and Objective: Understanding the regulatory mechanisms involving neuronatin (NNAT) in non-small cell lung cancer (NSCLC) is an ongoing challenge. This study aimed to elucidate the impact of NNAT knockdown on NSCLC by employing both in vitro and in vivo approaches. Methods: To investigate the role of NNAT, its expression was silenced in NSCLC cell lines A549 and H226. Subsequently, various
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IL-33/ST2 Signaling and its Correlation with Macrophage Heterogeneity and Clinicopathologic Features in Human Intrahepatic Cholangiocarcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Aimaiti Yasen, ZhanDong Yang, Jun Feng, RunBin Liang, TianXing Dai, Kai Li, YuHong Cai, GuoYing Wang
Background: IL-33/ST2 signaling plays crucial roles in the development and progression of various human malignancies. However, its significance in intrahepatic cholangiocarcinoma (ICC) still remains unclear. background: IL-33/ST2 signaling plays crucial roles in the development and progression of various human malignancies. However, its significance in intrahepatic cholangiocarcinoma (ICC) still remains
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Vitamin B12 Protects Against Genotoxicity Induced by Cisplatin Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Wejdan M. Al-Bataineh, Karem H. Alzoubib, Omar F. Khabour, Amjad Mahasneh, Enaam M. Almomani
Background: Cisplatin is an effective synthetic chemotherapeutic drug used for cancer treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate the effect of vitamin B12 on chromosomal damage induced by cisplatin. Methods: The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) were measured in cultured human blood lymphocytes
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PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Qingqiong Luo, Sheng Hu, Yijie Tang, Dandan Yang, Qilong Chen
Background: Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in the head and neck. Elucidating molecular mechanisms underlying OSCC occurrence and development is important for the therapy. Dysregulated palmitoylation-related enzymes have been reported in several cancers but OSCC. Objective: To explore the role of palmitoyl protein thioesterase 1 (PPT1) in
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Angiogenesis and Pancreatic Cancer: Novel Approaches to Overcome Treatment Resistance Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Craig Grobbelaar, Mpho Kgomo, Peace Mabeta
: Pancreatic cancer (PCa) is acknowledged as a significant contributor to global cancer- related mortality and is widely recognized as one of the most challenging malignant diseases to treat. Pancreatic ductal adenocarcinoma (PDAC), which is the most common type of PCa, is highly aggressive and is mostly incurable. The poor prognosis of this neoplasm is exacerbated by the prevalence of angiogenic molecules
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Clinical Significance of HHLA2 as a Novel Therapeutic Target for Colorectal Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-02-01 Hongbo Wang, Zhonghua An, Yingzhou Liu, Guanghui Ding, Guojin Deng, Changsheng Ji, Yanling Gong
Background: Colorectal cancer (CRC) is a high-indence malignance of the digestive system with a high mortality rate in the world. Aim: The results are desired to provide an important theoretical basis for discovering new therapeutic targets for CRC. Objective: The expression of human endogenous retrovirus-H-long terminal repeat association protein 2 (HHLA2) in human CRC was detected to explore its
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Effect of HPV Oncoprotein on Carbohydrate and Lipid Metabolism in Tumor Cells Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-29 Biqing Chen, Yichao Wang, Yishi Wu, Tianmin Xu
: :High-risk HPV infection accounts for 99.7% of cervical cancer, over 90% of anal cancer, 50% of head and neck cancers, 40% of vulvar cancer, and some cases of vaginal and penile cancer, contributing to approximately 5% of cancers worldwide. The development of cancer is a complex, multi-step process characterized by dysregulation of signaling pathways and alterations in metabolic pathways. Extensive
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Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-29 Vahideh Keyvani, Zari Naderi Ghale-noie, Samaneh Mollazadeh, Reihaneh Alsadat Mahmoudian, Elnaz Ghorbani, Hamid Naderi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan, Kazem Anvari
: Exosomes are very small (nano-sized) vesicles participating in tumor development by involvement in intercellular communication mediated by transferring biocomponents. Exosomes appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy in women. Several hallmarks of ovarian cancer are reported to be affected by the exosome-- mediated cellular cross-talk,
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Cancer and Autoimmune Diseases as Two Sides of Chronic Inflammation - and the Method of Therapy Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-29 Vladimir Rogovskii
: Chronic inflammation is associated with a prolonged increase in various inflammatory factors. According to clinical data, it can be linked with both cancer and autoimmune diseases in the same patients. This raises the critical question of how chronic inflammation relates to seemingly opposing diseases - tumors, in which there is immunosuppression, and autoimmune diseases, in which there is over-activation
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The Role of Bile Acids in Pancreatic Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-29 Yanling Wang, Haiyan Xu, Xiaofei Zhang, Jingyu Ma, Shengbai Xue, Daiyuan Shentu, Tiebo Mao, Shumin Li, Ming Yue, Jiujie Cui, Liwei Wang
: Bile acids are well known to promote the digestion and absorption of fat, and at the same time, they play an important role in lipid and glucose metabolism. More studies have found that bile acids such as ursodeoxycholic acid also have anti-inflammatory and immune-regulating effects. Bile acids have been extensively studied in biliary and intestinal tumors but less in pancreatic cancer. Patients
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Elucidating the Role of Pro-renin Receptors in Pancreatic Ductal Adenocarcinoma Progression: A Novel Therapeutic Target in Cancer Therapy Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-26 Mohsen Aliakbarian, Gordon A. Ferns, Mahmoud Mohamadzadeh Shabestari, Amir Mahmoud Ahmadzadeh, Aref Abdollahzade, Hoda Rahimi, Rozita Khodashahi, Mohammad-Hassan Arjmand
:: Pancreatic cancer is a highly aggressive malignancy with a very poor prognosis. The 5- year survival in these patients is very low, and most patients develop drug resistance to current therapies, so additional studies are needed to identify the potential role of new drug targets for the treatment of pancreatic cancer. Recent investigations have been performed regarding the roles of pro-renin receptors
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Treatment Advances in Lung Cancer with Leptomeningeal Metastasis Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-26 Yuan Meng, Meiying Zhu, Jie Yang, Xuerui Wang, Yangyuying Liang, Minghui Yu, Longhui Li, Fanming Kong
: Leptomeningeal metastasis (LM) is a serious and often fatal complication in patients with advanced lung cancer, resulting in significant neurological deficits, decreased quality of life, and a poor prognosis. This article summarizes current research advances in treating lung cancer with meningeal metastases, discusses clinical challenges, and explores treatment strategies. Through an extensive review
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Novel Association of RAD54L Mutation with Müllerian Clear Cell Carcinoma of the Male Urethra: New Insights Regarding the Molecular Mechanisms of a Rare Tumour Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-26 Huiyan Deng, Yan Ding, Danjing Yin, Ying Jia, Zhiyu Wang, Xiangdong Liang, Yueping Liu
Introduction: Müllerian clear cell carcinoma of the male urethra is similar to that of the female genital tract in terms of morphology and immunohistochemical expression but is rarely observed in clinical practice. Case Presentation: Here, we report the case of a 65-year-old man diagnosed with Müllerian clear cell carcinoma who harboured a mutation in RAD54L. This patient was diagnosed by electrocautery
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Efficacy and Safety of Phosphatidylinositol 3-kinase Inhibitors for Patients with Breast Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-25 Yi Wang, Xianling Du, Hongqiang Xin, Ruimin Xu
Background:: Phosphatidylinositol 3-kinase (PI3K) inhibitors belong to the class of drugs that inhibit the activity of the PI3K protein, which is commonly overexpressed in breast cancer cells. However, there is a need to summarize the evidence to provide conclusive advice on the benefit of PI3K inhibitors in breast cancer patients. Therefore, this review assessed the effectiveness and safety of the
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Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-25 Zongrui Xing, Xiangyan Jiang, Yuxia Wu, Zeyuan Yu
:: Tumors of the digestive system are currently one of the leading causes of cancer-related death worldwide. Despite considerable progress in tumor immunotherapy, the prognosis for most patients remains poor. In the tumor microenvironment (TME), tumor cells attain immune escape through immune editing and acquire immune tolerance. The mevalonate pathway and autophagy play important roles in cancer biology
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Bromodomain Protein-directed Agents and MYC in Small Cell Lung Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-25 Gerhard Hamilton, Sandra Stickler, Barbara Rath
:: Small cell lung cancer (SCLC) has a dismal prognosis. In addition to the inactivation of the tumor suppressors TP53 and RB1, tumor-promoting MYC and paralogs are frequently overexpressed in this neuroendocrine carcinoma. SCLC exhibits high resistance to second-line chemotherapy and all attempts of novel drugs and targeted therapy have failed so far to achieve superior survival. MYC and paralogs
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Immunologic Crosstalk of Endoplasmic Reticulum Stress Signaling in Bladder Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-24 Shun Wan, Kun-peng Li, Chen-Yang Wang, Jian-wei Yang, Si-Yu Chen, Hua-Bin Wang, Xiao-ran Li, Li Yang
: Bladder cancer (BC) is a common malignant tumor of the urinary system. While current approaches involving adjuvant chemotherapy, radiotherapy, and immunotherapy have shown significant progress in BC treatment, challenges, such as recurrence and drug resistance, persist, especially in the case of muscle-invasive bladder cancer (MIBC). This is mainly due to the lack of pre-existing immune response
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Prognostic Significance and Functional Mechanism of UTS2 in Glioblastoma Multiforme Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-24 Yanfei Wang, Langping Shen, Mingzhong Sun
Aim: We aimed to explore the role of urotensin 2 (UTS2) in glioblastoma (GBM). Background: GBM is the most malignant primary brain cancer with a poor prognosis. Previous studies have suggested that GBM vessels undergo dynamic remodeling modulated by tumor vasodilation and vasoconstriction instead of tumor angiogenesis Objective: Here, we have first investigated the expression and function of UTS2,
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Tectorigenin Inhibits Glycolysis-induced Cell Growth and Proliferation by Modulating LncRNA CCAT2/miR-145 Pathway in Colorectal Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-21 Ying Xing, Bofan Lin, Baoxinzi Liu, Jie Shao, Zhichao Jin
Background: Colorectal cancer (CRC) places a heavy burden on global health. Tectorigenin (Tec) is a type of flavonoid-based compound obtained from the Chinese medical herb Leopard Lily Rhizome. It was found to exhibit remarkable anti-tumor properties in previous studies. However, the effect and molecular mechanisms of Tec in colorectal cancer have not been reported. Objective: The objective of this
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Neuroinflammation in Glioblastoma: The Role of the Microenvironment in Tumour Progression Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-17 Ana Helena Larangeira Nóbrega, Rafael Sampaio Pimentel, Ana Paula Prado, Jenifer Garcia, Rudimar Luiz Frozza, Andressa Bernardi
Glioblastoma (GBM) stands as the most aggressive and lethal among the main types of primary brain tumors. It exhibits malignant growth, infiltrating the brain tissue, and displaying resistance toward treatment. GBM is a complex disease characterized by high degrees of heterogeneity. During tumour growth, microglia and astrocytes, among other cells, infiltrate the tumour microenvironment and contribute
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The Tumor Immune Microenvironment plays a Key Role in Driving the Progression of CholangioCarcinoma Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-12 Ye Zhang, Hai-jiao Yan, Jun Wu
: Cholangiocarcinoma (CCA) is an epithelial cancer distinguished by bile duct cell differentiation and is also a fibroproliferative tumor. It is characterized by a dense mesenchyme and a complex tumor immune microenvironment (TME). The TME comprises both cellular and non-cellular components. The celluar component includes CCA cells, immune cells and mesenchymal cells represented by the cancer-associated
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Investigating the Influence of Gut Microbiota-related Metabolites in Gastrointestinal Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-11 Zeynab Marzhoseyni, Zahra Shaghaghi, Maryam Alvandi, Maria Shirvani
Gastrointestinal (GI) cancer is a major health concern due to its prevalence, impact on well-being, high mortality rate, economic burden, and potential for prevention and early detection. GI cancer research has made remarkable strides in understanding biology, risk factors, and treatment options. An emerging area of research is the gut microbiome's role in GI cancer development and treatment response
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Deubiquitylase USP31 Induces Autophagy and Promotes the Progression in Lung Squamous Cell Carcinoma Cells by Stabilizing E2F1 Expression Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-11 Wenjun Liang, Mingxia Yang, Xiaohua Wang, Yan Qian, Ruichen Gao, Yujia Shi, Xuejun Shi, Lei Shi, Ting Xu, Qian Zhang
Background: Autophagy exerts a vital role in the progression of lung squamous cell carcinoma (LUSC). Ubiquitin-specific peptidase 31 (USP31) has recently been found to be involved in the development of a variety of cancers. However, whether USP31 modulates autophagy in LUSC remains unclear. Methods: This study revealed that high levels of USP31 were discovered in LUSC tissue samples employing the Gene
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IR-780 Dye-based Targeting of Cancer-associated Fibroblasts Improves Cancer Immunotherapy by Increasing Intra-tumoral T Lymphocytes Infiltration Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-05 Wei Yang, Zelin Chen, Langfan Qu, Can Zhang, Hongdan Chen, Jiancheng Zheng, Wanchao Chen, Xu Tan, Chunmeng Shi
Background: Immune-checkpoint inhibitors (ICIs) against programmed death (PD)-1/PD-L1 pathway immunotherapy have been demonstrated to be effective in only a subset of patients with cancer, while the rest may exhibit low response or may develop drug resistance after initially responding. Previous studies have indicated that extensive collagen-rich stroma secreted by cancer-associated fibroblasts (CAFs)
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CT109-SN-38, a Novel Antibody-drug Conjugate with Dual Specificity for CEACAM5 and 6, Elicits Potent Killing of Pancreatic Cancer Cells Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-05 Kelly C. Arias Cardenas, Clinton W. Enos, Mark R. Spear, Dana E. Austin, Raghad Almofeez, Stephanie Kortchak, Lauren Pincus, Hua-bei Guo, Samuel Dolezal, J. Michael Pierce, Emma Furth, Cyrille Gineste, Yongjun Kwon, Cohava Gelber
Background:: CEACAM5 and CEACAM6 are glycosylphosphatidylinositol (GPI)- linked members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, which are frequently upregulated in epithelial cancers where they contribute to invasion, metastasis, immune evasion, and resistance to anoikis. CT109 is a novel antibody with dual specificity to both CEACAM5 and 6. Objective:: In this
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Real-world Study on the Effect of PARPi as Maintenance Therapy on Platinum Sensitivity after First- and Second-line Chemotherapy in Patients with Recurrent High-grade Serous Epithelial Ovarian Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-04 Yanglong Guo, Xi Chen, Xuedong Tang, Shan Pan, Tao Zhu, Yingli Zhang
Background: This study investigated the effect of poly(ADP-ribose) polymerase inhibitors (PARPi) as maintenance therapy after first- and second-line chemotherapy on platinum sensitivity in patients with recurrent high-grade serous epithelial ovarian cancer (rHGSOC). Methods: This study retrospectively analyzed 172 patients with rHGSOC treated at Zhejiang Cancer Hospital and Jiaxing Maternity and Child
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Establishment and Validation of a Blood Test-based Nomogram to Diagnose Patients with AFP-negative HCC Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2024-01-03 Yujing Wu, Shuang Liu, Zhijuan Fan, Yaqiong Tian, Lei Zhang, Shuye Liu
Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. Alpha-protein (AFP) is the most widely used blood biomarker for HCC. However, elevated serum AFP is only observed in part of HCC. Aims: This study aimed to develop an efficient nomogram model to distinguish patients with alpha- protein-negative HCC and liver cirrhosis. Objective: A total of 1130 patients
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Apoptin Inhibits Glycolysis and Regulates Autophagy by Targeting Pyruvate Kinase M2 (PKM2) in Lung Cancer A549 Cells Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2023-12-27 Gaojie Song, Chao Shang, Yilong Zhu, Zhiru Xiu, Yaru Li, Xia Yang, Chenchen Ge, Jicheng Han, Ningyi Jin, Yiquan Li, Xiao Li, Jinbo Fang
Background: Pyruvate kinase M2 (PKM2) is a key enzyme in aerobic glycolysis and plays an important role in tumor energy metabolism and tumor growth. Ad-apoptin, a recombinant oncolytic adenovirus, can stably express apoptin in tumor cells and selectively causes cell death in tumor cells. Objective: The relationship between the anti-tumor function of apoptin, including apoptosis and autophagy activation
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Combined RNAi of CTTN and FGF2 Modulates Cell Migration, Invasion and G1/S Transition of Hepatocellular Carcinoma through Ras/ERK Signaling Pathway Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2023-11-30 Jiaming Zhou, Jiaxuan Liu, Tiejun Li, Qiang Zhong, Hongyu Yu
Background: Most patients with hepatocellular carcinoma (HCC) die of rapid progression and distant metastasis. Gene therapy represents a promising choice for HCC treatment, but the effective targeted methods are still limited. Objective: CTTN/cortactin plays a key role in actin polymerization and regulates cytoskeleton remodeling. However, the interaction network of CTTN in HCC is not well understood
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An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2023-11-29 Shruthi Nagainallur Ravichandran, Makalakshmi Murali Kumar, Alakesh Das, Antara Banerjee, Suhanya Veronica, Alexander Sun-Zhang, Hong Zhang, Muralidharan Anbalagan, Xiao-Feng Sun, Surajit Pathak
Colorectal cancer is one of the most common cancer types worldwide. Since colorectal cancer takes time to develop, its incidence and mortality can be treated effectively if it is detected in its early stages. As a result, non-invasive or invasive biomarkers play an essential role in the early diagnosis of colorectal cancer. Many experimental studies have been carried out to assess genetic, epigenetic
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Comprehensive Analyses and Experiments Confirmed IGFBP5 as a Prognostic Predictor Based on an Aging-genomic Landscape Analysis of Ovarian Cancer Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2023-11-29 Ting-Yu Fan, Li-li Xu, Hong-feng Zhang, Juan Peng, Dan Liu, Wen-Da Zou, Wen-jie Feng, Mei Qin, Juan Zhang, Hui Li, Yu-Kun Li
Background:: Ovarian cancer (OC) is one of the malignant diseases of the reproductive system in elderly women. Aging-related genes (ARGs) were involved in tumor malignancy and cellular senescence, but the specifics of these mechanisms in OC remain unknown. Methods:: ARGs expression and survival data of OC patients were collected from TCGA and CPTAC databases. Subtype classification was used to identify
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Bioinformatics and Experimental Study Revealed LINC00982/ miR-183-5p/ABCA8 Axis Suppresses LUAD Progression Curr. Cancer Drug Targets (IF 3.0) Pub Date : 2023-11-22 Defang Ding, Jingyu Zhong, Yue Xing, Yangfan Hu, Xiang Ge, Weiwu Yao
Background: Lung adenocarcinoma (LUAD) is a major health challenge worldwide with an undesirable prognosis. LINC00982 has been implicated as a tumor suppressor in diverse human cancers; however, its role in LUAD has not been fully characterized. Methods: Expression level and prognostic value of LINC00982 were investigated in pan-cancer and lung cancer from The Cancer Genome Atlas (TCGA) project. Differential